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Rozprawy doktorskie na temat „Epithelium”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Drag, Melvyn I. "Epithelium: The lightweight, customizable epithelial tissue simulator." The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1430011382.

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2

Rowley, Jessica. "The interaction of Aspergillus fumigatus with the respiratory epithelium." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-interaction-of-aspergillus-fumigatus-with-the-respiratory-epithelium(0fc10449-977d-4f14-a169-172e8204fee4).html.

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Aspergillus fumigatus is a filamentous fungus and the main pathogen responsible for the often fatal respiratory condition, aspergillosis. Airway epithelial cells (AECs) are likely to be the first line of host defence that come into contact with the inhaled conidia of A. fumigatus. Recent evidence strongly suggests that the response of the airway epithelium to inhaled pathogens is pivotal in orchestrating immune responses by inducing phagocytic-like reactions and the secretion of inflammatory cytokines and antimicrobial peptides. However, the majority of previous work investigating A. fumigatus

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3

Zhu, Yihong. "Tight junction in ovarian surface epithelium and epithelial ovarian tumors /." Göteborg : Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska University Hospital, The Sahlgrenska Academy at Göteborg University, 2007. http://hdl.handle.net/2077/3167.

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4

Tipoe, George Lim. "A histological and ultrastructural morphometric assessment of malignant potential in human colorectal epithelium." Thesis, [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13641347.

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5

Stevens, Paul. "Intrinsic differences of the airway epithelium in childhood allergic asthma." University of Western Australia. School of Paediatrics and Child Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0022.

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[Truncated abstract] Asthma affects millions of people worldwide and places a substantial burden on the healthcare system. Despite advances in our understanding of disease mechanisms and the role of respiratory viruses in asthma exacerbations, there is little known regarding the role of the epithelium in commonly observed structural changes in the airway wall. The epithelium of the airways provides an essential protective barrier between the environment and underlying structures and is responsible for the secretion of diverse compounds. Since it is likely that dysregulated epithelial character

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6

Hong, Hee Ling. "Regulation of neutral proteinase and plasminogen activator secretion by epithelial cells in vitro." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/24687.

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The aim of this thesis was to study the regulation of proteinase secretion by epithelial cells (E-cells) derived from the epithelial cell rests of Malassez. Since these epithelial cell rests are present only in small numbers in-vivo, E-cells derived from porcine cell rests were cultured according to Brunette et al. (1976) and conditions chosen so that detectable amounts of the proteinases, neutral proteinase and plasminogen activator, could be obtained. The regulation of the secretion of these enzymes was investigated by varying the cell population density, adding E.Coli lipopolysaccharide to

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7

FORTNER, CHRISTOPHER NEIL. "EPITHELIUM-DEPENDENT RELAXATION OF AIRWAY SMOOTH MUSCLE IS LINKED TO EPITHELIAL CHLORIDE CURRENTS." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin983467525.

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8

Meredith, David. "Oligopeptide transport in lung epithelium." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357416.

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9

Thomas, Biju. "Ciliated epithelium in respiratory diseases." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/9568.

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Background: The ciliated respiratory epithelium that covers the surface of human airway forms an immunologically active natural barrier to invasion and injury by inhaled noxious agents. Ciliary dysfunction and or epithelial damage compromise this innate defence mechanism. Aim: To study the ciliary function and epithelial ultrastructure of adult patients with asthma and paediatric lung transplant recipients. To study the response of bronchial epithelial cells of patients with atopic severe asthma, to allergen and bacteria. Methods: Digital high speed video microscopy was used to study the cilia

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10

Talebizadeh, Nooshin. "Caspase-3 in lens epithelium." Doctoral thesis, Uppsala universitet, Oftalmiatrik, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-267543.

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Purpose: To model the time evolution of active caspase-3 protein expression in a healthy lens, and in a lens exposed to UVR-300 nm (UVR-B). To develop an automated method to classify the fluorescent signal of biomarkers in the lens epithelial cells. Methods: Six-week old Sprague-Dawley rats were used. Firstly, expression of active caspase-3 was studied in the lens epithelium of healthy rats. Secondly, rats were unilaterally exposed in vivo to 1 kJ/m2 UVR-B for 15 minutes. At 0.5, 8, 16, and 24 hours after the UVR-B exposure, the exposed and the contralateral non-exposed lenses were removed. Im

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11

Domínguez, Hüttinger Elisa. "Mathematical modelling of epithelium homeostasis." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/47969.

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The body and organs of all animals are covered by epithelial tissues, such as the epidermis and the airway epithelium. Epithelial tissues play a key role in protecting the body from environmental aggressors. Failure to maintain a competent epithelium can lead to the onset of many diseases, including Atopic dermatitis (AD) and infection by Streptococcus pneumoniae. Treatment of AD is currently restricted to the relief of symptoms, mainly because the underlying mechanisms remain elusive. Antibiotic resistance threatens the effectiveness of the prevalent treatments for infection. Devising new and

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12

Kalair, Waseem. "Isolation and transplantation of murine intestinal stem cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0016/MQ59179.pdf.

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13

Brocchieri, Cristian. "A study on the regulation of Epithelial to Mesenchymal Transition in the Ovarian Surface Epithelium." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611315.

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14

Carter, Lauren. "Defining the Epithelial-to-Mesenchymal Transition and Regulation of Stemness in the Ovarian Surface Epithelium." Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38491.

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The ovarian surface epithelium (OSE) is a monolayer of cells surrounding the ovary that is ruptured during ovulation. After ovulation the wound is repaired, however this process, and the mechanisms to maintain OSE homeostasis after the wound is repaired are poorly understood. We have shown the mouse OSE (mOSE) contains a stem cell population that is expanded by Transforming Growth Factor Beta 1 (TGFB1), a factor present in follicular fluid. These data suggest that components in the follicular fluid such as TGFB1 may promote wound repair and OSE homeostasis through maintenance of the OSE stem c

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15

Lau, Janet. "Hedgehog signaling in the pancreas epithelium." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398879.

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16

Schmachtenberg, Oliver. "Nitric oxide in the olfactory epithelium." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962820598.

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17

Nilsson, Jan Anders. "Aldehyde toxicity in human oral epithelium /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-141-5/.

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18

Calderon-Zapatal, Moises Antonio. "The nasal epithelium, atopy and inflammation." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286273.

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19

O'Connor, M. G. "Apoptosis in intestinal epithelium during regeneration." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411844.

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20

McLennan, Ross Kenneth James. "Vesicle trafficking in a Drosophila epithelium." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398536.

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21

Wei, Jun. "Development of the first vertebrate epithelium." Thesis, University of Bath, 2011. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538125.

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A conserved feature of early vertebrate embryos is the formation of simple epithelial layer of cells which surrounds the embryo and protects it from the external environment. This epithelium is called the trophectoderm in mammals, the superficial layer in Xenopus and the enveloping layer in zebrafish. This project investigates what promotes differentiation of this cell type. In Xenopus embryos aPKC and Notch signalling were found to be unable to promote differentiation of the superficial layer. In contrast, BMP signalling can promote expression of a number of transcriptional regulators, includ

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22

Owen-Jones, Catrin Eleri. "Stem cells in human oral epithelium." Thesis, Cardiff University, 2004. http://orca.cf.ac.uk/55544/.

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The stratifying epithelia of skin and mucosa continuously renew their structure by cell division, but only a small fraction of proliferative cells, the stem cells, are capable of continuous self-renewal. The staining distribution of various stem cell and differentiation markers were investigated in normal human mucosal epithelium. To determine the extent of regional variation in patterns of stem cell behaviour in human epithelia, human mucosal keratinocytes were amplified in vitro. Using retroviral vectors, a sub-population of these cells were transduced with genes for histochemically detectab

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23

Anantharam, Arun. "Structure and regulation of the epithelial sodium channel /." Access full-text from WCMC :, 2007. http://proquest.umi.com/pqdweb?did=1445057221&sid=9&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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24

Liu, Ke. "Role of second messengers in controlling growth patterns of corneal epithelial cells /." View thesis, 2002. http://library.uws.edu.au/adt-NUWS/public/adt-NUWS20030718.102224/index.html.

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Thesis (Ph. D.)--University of Western Sydney, 2002.<br>"This thesis is submitted in fulfilment of the requirements of the degree of Doctor of Philosophy to the University of Western Sydney School of Biological Sciences."t.p. Includes bibliographical references (leaves 138-150).

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25

Johnston, Richard A. "Characterization of the airway epithelial bioelectric mechanisms associated with the effects of epithelium-derived relaxing factor in guinea-pig isolated trachea." Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1776.

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Thesis (Ph. D.)--West Virginia University, 2000.<br>Title from document title page. Document formatted into pages; contains ix, 135 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 127-135).

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26

Papacleovoulou, Georgia. "Steroid signalling in the human ovarian surface epithelium wound healing." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4237.

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The human ovarian surface epithelium (hOSE) is a cell monolayer that covers the surface of the ovary. Natural events like incessant ovulation, associated reproductive hormone action prior to and post-ovulation, along with the ovulationassociated inflammation, that result in injury and repair of hOSE, are considered to have a role in the development of epithelial ovarian cancer (EOC). Progesterone is apoptotic and anti-inflammatory, whereas androgens appear cytoproliferative for hOSE. Local generation of these steroid hormones is subject to 3β-hydroxysteroid dehydrogenase (3β-HSD) activity. Mor

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27

Chowdhury, Ferdousi. "Epithelial tight junction function in a co-culture model of the human bronchial epithelium and endothelium." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404190.

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28

Scull, Margaret Adele Pickles Raymond J. "Myxovirus interaction with the human airway epithelium." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2848.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2009.<br>Title from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology." Discipline: Microbiology and Immunology; Department/School: Medicine.

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29

Al-Hosaini, Heba. "Age-related changes in retinal pigment epithelium." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444089/.

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The retinal pigment epithelium (RPE) is a monolayer of hexagonal organized cells located between the choriocapillaris and the neurosensory retina. As the RPE is implicated in a range of eye diseases, an understanding of its structure and ability for self renewal is critical for therapeutic strategies. Analysis of human RPE cells at the extreme periphery of the retina reveals a population larger in size than those in the centre, they are highly irregular and form an annulus of 4-5 mm. Although binucleation in humans is rare, 10% of these cells are binucleated. In the central region these large

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30

Donahue, Vicki S. "Phospholipase c activity in retinal pigment epithelium." Virtual Press, 1997. http://liblink.bsu.edu/uhtbin/catkey/1041916.

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The role of the retinal pigment epithelial cells on the viability and renewal of photoreceptors has been well demonstrated in the Royal College of Surgeons (RCS) strain of rat. These rats are characterized by an inherited time-dependent degeneration of their photoreceptors. This degeneration is apparently due to the inability of the retinal pigment epithelial cells to adequately ingest fragments of photoreceptor membrane that are shed during the course of photoreceptor membrane renewal. The buildup of photoreceptor material in the interphotoreceptor space ultimately leads to the degeneration o

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31

MacPherson, Matthew. "Calcium signalling in a fluid transporting epithelium." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341710.

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32

Warner, Jacqueline. "Ionic transport across mammalian retinal pigment epithelium." Thesis, University of Westminster, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292857.

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33

Walker, Dawn Carol. "Modelling the electrical properties of cervical epithelium." Thesis, University of Sheffield, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392721.

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34

Scully, Jaqueline Susan. "Insertion of oncogenes into mouse mammary epithelium." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315287.

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35

Milward, Michael Robert. "Oral epithelium in the pathogenesis of periodontitis." Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/1007/.

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Pocket/sulcular epithelium is the first line of defence to plaque bacteria and its potential role in periodontitis is investigated. This thesis describes the development of a model system, utilising an immortal epithelial cell line (H400) in order to investigate responses to periodontal pathogen stimulation (P. gingivalis and F. nucleatum) in terms of NF-\(\kappa\)B activation, differential gene expression and cytokine production. The pathogenesis of periodontitis suggests that susceptible patients exhibit a hyper-inflammatory response to plaque bacteria, so an attempt to modulate the pro-infl

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36

Chen, F. K. "Retinal pigment epithelium transplantation in retinal diseases." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1318070/.

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Age-related macular degeneration (AMD) and inherited macular diseases (IMD) are retinal disorders that can cause blindness through atrophy of the retinal pigment epithelium (RPE) or choroidal neovascularisation (CNV). RPE transplantation in severe forms of neovascular AMD has been performed with promising short-term outcomes. However, this approach has not been evaluated in atrophic types of AMD or IMD. Furthermore, the long-term outcomes of photoreceptors cell function rescue by RPE reconstruction in neovascular AMD is unknown. Current surgical techniques are complex with associated high comp

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37

Thomas, Rebecca Ann. "Effect of stretch on the bronchial epithelium." Thesis, University of Leicester, 2004. http://hdl.handle.net/2381/29487.

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This thesis describes the use of a model of cell deformation to measure the effect of stretch on mediator release or expression by airway epithelial cells, and to assess the method of mechanotransduction in these cells. Cells were cyclically stretched using the Flexercell system delivering biaxial stretch. IL-8 release by BEAS 2B cells was increased by cytokine stimulation and stretch, in a dose, time and rate dependent manner, whereas RANTES levels in the cell supernatant and cell surface ICAM-1 expression decreased after stretch. 30% elongation at 20 cycles/minute for 24 hours increased IL-8

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38

Moradi, Emilia. "Folate-mediated macromolecule delivery across the epithelium." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/27899/.

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Folate uses the natural endocytosis pathway via the folate receptor (FR) to enter the cells. Folate conjugation to small or macromolecular therapeutics has hence been exploited for intracellular delivery to, particularly, cancerous cells. This work reports on the expression and functionality of FR in polarised cell monolayer models of respiratory and gastrointestinal mucosa with the view to assess its potential for delivery of folate-modified macromolecular therapeutics either intracellularly or across the epithelium. Four cell lines representing bronchial and intestinal epithelium; cancer-der

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39

Bhattacharya, Pradipta. "The corneal epithelium in health and disease." Thesis, Queensland University of Technology, 2022.

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The cornea is the anterior transparent layer of the eye, and understanding corneal epithelial morphology is valuable in monitoring ocular surface diseases. A meta-analysis showed that central corneal basal cell density and nerve parameters were reduced in diseases affecting the ocular surface including limbal stem cell deficiency. Using newly developed image analysis techniques it was observed that epithelial cell density was highest at the corneal nerve whorl region. A decrease in epithelial cell density was observed in eyes with conjunctival ultraviolet autofluorescence, i.e. with sunlight-i

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Lan, Li, and 藍莉. "A study of apoptosis in a human epithelial tumour cell line." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31238762.

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41

Hunjan, Anoop Singh, and Anoop Singh Hunjan. "Chronic Arsenite Exposure in Lung Epithelium Modulates Endocytosis." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626765.

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Arsenic exposure in humans has been implicated in the development of a myriad of non-cancerous and cancerous diseases. A reductionist approach to understanding this unusual phenomenon would suggest that arsenic-induced perturbation of a small number of fundamental biological processes could manifest as this diverse array of disease endpoints. Endocytosis is a fundamental cellular process involved in the internalization and transport of various extracellular molecules and membranous components. BEAS-2B, a human bronchial epithelial cell line, was used to characterize the effects of chronic arse

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42

Ivert, Lena. "Interactions between neural retina, retinal epithelium and choroid /." Stockholm : Section of ophthalmology and vision, Department of clinical neuroscience, Karolinska institutet, 2006. http://diss.kib.ki.se/2006/91-7140-797-9/.

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43

Stumpff, Friederike [Verfasser]. "Ionic conductances of the ruminal epithelium / Friederike Stumpff." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025355377/34.

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44

Fox, Emma. "Systemic delivery of DNA to the airway epithelium." Thesis, Imperial College London, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409742.

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45

Mort, Richard Lester. "Stem cell function in the mouse corneal epithelium." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/8187.

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Limbal stem cells maintain the corneal epithelium through a process of clonal growth and ordered migration. In X-inactivation mosaic female mice, that express LacZ from one of their X-chromosomes, random clumps of LacZ-positive cells are seen in the cornea at 3-6 weeks of life. This pattern resolves between 6-10 weeks forming radial stripes thought to represent chords of clonally related, inwardly migrating cells. By measuring the number and width of stripes and correcting for the effects of different proportions of LacZ-positive cells, an estimate of the number of coherent stem cell clones ma

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46

Foley, Charlotte Louise. "Characterisation of human prostate epithelium colony forming cells." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444718/.

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Objectives: Rare prostate epithelial stem cells have been implicated in the aetiology of prostate disease, yet are overlooked in studies on the whole tissue. When prostate epithelial cells are cultured at low density, two distinct colony types arise, postulated to represent the progeny of stem cells (type II colonies) and committed 'transit amplifying' cells (type I). This project aimed to further characterize these rare colonies and confirm their position in the prostate epithelial cell hierarchy, in benign, and for the first time, malignant tissue. Methods: Colonies derived from transurethra

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47

Ahmad, Sajjad. "The culture of human limbal epithelium for transplantation." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440580.

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48

Devine, Lesley. "Cellular interactions between lymphocytes and retinal pigment epithelium." Thesis, University College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338652.

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49

Sheridan, Carl Michael. "The retinal pigment epithelium and its extracellular matrix." Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366682.

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50

Green, Graeme Lister. "The bacterial flora associated with the human epithelium." Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441254.

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