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Rozprawy doktorskie na temat „Experimental medicine”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 29 lipca 2024

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1

Strickland, Thomas. "Experimental spaces: megastructures, medicine and McMaster." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=110431.

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This thesis is an architectural study that focuses on an anxious and exciting period for medicine and architecture between 1960 and 1975. This time was an important moment of adjustment and adaptation for medicine, architecture and community. Collateral to the establishment of national health insurance (Medicare, 1966), architects and hospital planners sought to use the space of the hospital to foster this new relationship with their constituency. This happened in multiple and surprising ways, from the introduction of public spaces in hospitals, to a medical exhibit at Expo 67 that was as much

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2

Olofsson, Pia. "Experimental studies on Damage Control Surgery and Intraabdominal Hypertension." Doctoral thesis, Linköpings universitet, Kirurgi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17796.

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Damage control surgery (DCS) offers an alternative to the traditional surgical management of complex or multiple injuries in critically injured patients. If a patient survives the initial phase of DCS, complications may occur, one of these being intraabdominal hypertension (IAH) and it´s potential development into the abdominal compartment syndrome. The indications for DCS have been widened and DCS principles can be applied in situations where time and resources are essential factors. The DCS principles of rapidly controlling intestinal spillage have not been evaluated. The aim of the studies

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3

Amandusson, Åsa. "Estrogen Receptor Expression in Relation to Pain Modulation and Transmission: Experimental Studies in Rats." Doctoral thesis, Linköpings universitet, Cellbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-17978.

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Estrogens have a remarkably wide range of actions in the mammalian brain. They not only play a pivotal role in reproductive behavior and sexual differentiation, but also contribute to e.g. thermoregulation, feeding, memory, neuronal survival and the perception of somatosensory stimuli. A multitude of studies on both animals and human subjects has demonstrated potential effects of gonadal hormones, such as estrogens, on pain transmission. These effects most likely involve multiple neuroanatomical circuits as well as diverse neurochemical systems and therefore need to be evaluated specifically i

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4

Samuelsson, Anders. "Effects of burns and vasoactive drugs on human skin : Clinical and Experimental studies using microdialysis." Doctoral thesis, Linköpings universitet, Anestesiologi med intensivvård, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-59519.

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Patients who require critical care, including those with burns, are affected by a systemic inflammatory reaction, which at times has consequences such as multiple organ dysfunction and failure. It has become increasingly evident that other factors important in the development of organ dysfunction are disturbances at the tissue level, in the microcirculation. Such disturbances activate cascade systems including stress hormones, all of which have local effects on organ function. Despite this knowledge, monitoring and treatment in critical illness today relies mainly on central haemodynamics and

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5

Blakytny, Robert. "Experimental cataract and its prevention." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333181.

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6

Hillman, Nicola Jane. "Hypertension and experimental diabetic retinopathy." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241987.

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7

Hübbert, Laila. "Between the Probe and the Pump : An experimental study on cardiac performance analysis based on Echocardiography, tissue and laser Doppler." Doctoral thesis, Linköpings universitet, Kardiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-61518.

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Echocardiography is an ultrasound-based bedside, non-invasive and easily available cardiac diagnostic technique visualising the heart’s morphology and function. Quantification of cardiac wall motion can be measured with the tissue Doppler Imaging (TDI) modality which provides in humans a high diagnostic capacity to differentiate healthy from diseased myocardium with reduced function. Heart failure, as a consequence of, for example, myocardial or ischaemic heart disease, demands both bedside and intraoperative diagnostic procedures for myocardial functional and perfusion assessment. In the late

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8

Leclair, Robert J. "X-ray scatter imaging in medicine, model and experimental validation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0017/NQ57615.pdf.

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9

Leclair, Robert J. (Robert Joseph) Carleton University Dissertation Physics. "X-ray scatter imaging in medicine; model and experimental validation." Ottawa, 2000.

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10

Galloway, D. J. "Dietary manipulation of experimental colorectal cancer." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374513.

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11

Pekiner, Can. "Molecular remodelling in experimental diabetic neuropathy." Thesis, University of Liverpool, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317219.

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12

Ma, Jennifer. "Role of inhibitors of apoptosis proteins (IAPs) and Smac/DIABLO in regulating activated T-lymphocyte survival." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=95585.

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Activation of primary lymphocytes leads to the initiation of the apoptotic program • although cells do not undergo apoptosis. The aim of this study was to investigate the key regulatory proteins controlling caspase activation during T-Iymphocyte activation. We analyzed the apoptotic pathways in highly purified T-Iymphocytes. Our data revealed that following activation of T lymphocytes with a-CD3 and a-CD28 in the presence of IL-2, initial processing of caspase-3 took place into an inactive p20 fragment and the key substrates essential in mediating the apoptotic machinery were not cleaved. This

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13

Ker, Mary Virginia. "Using texture to predict diagnosis and disease from nuclear medicine lung perfusion scans: A comparison of nuclear medicine physicians to the slope of the power spectrum." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185562.

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The lung has been satisfactorily modelled as a fractal, and change in lung structure due to disease is assumed to change the fractal dimensionality of the lung. It is hypothesized that those changes in fractal dimension affect perceptually relevant elements (perceived texture) of the lung, and therefore the fractal dimension may prove to be a predictor of diagnosis. If the fractal dimensionality reflects structure in ways more accurately reflecting changes in lung structure than can be achieved by nuclear medicine physicians, then it may also prove useful as a diagnostic tool. Fractal dimensio

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14

MacPhee, I. A. M. "The cellular basis of experimental allergic encephalomyelitis." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235040.

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15

Stewart, Adrian John. "Clinical and experimental studies of ventricular fibrillation." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334535.

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16

Corcoran, John David Ross. "Surfactant replacement therapy : experimental and clinical studies." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387871.

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17

Lewis, Harry Lewis. "Experimental and clinical studies in acute pancreatitis." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387895.

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18

Diamond, Thomas. "Experimental aspects of endotoxaemia in obstructive jaundice." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334469.

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19

Jakes, Ian C. "An experimental investigation of obsessive compulsive disorder." Thesis, King's College London (University of London), 1992. https://kclpure.kcl.ac.uk/portal/en/theses/an-experimental-investigation-of-obsessive-compulsive-disorder(eaf9023a-2ed0-4e7f-b7dc-1fde9c5dee50).html.

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The thesis is divided into four parts. In Part A, what are termed the "standard diagnostic criteria" for Obsessive-Compulsive Disorder" (OCD) are reviewed, and argued to be implausible. The beginnings of an alternative approach to the definition of the disorder are presented. Empirical investigations of the characteristics of obsessive-compulsive experience among OCD sufferers are also reported. The results of these investigations both confirm the critique of the "standard diagnostic criteria", and are consistent with previous phenomenological investigations of OCD patients. Judgment is suspen

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20

PORCU, ELENA PIERA. "Development of novel platforms for diagnosis and therapy in experimental medicine." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1215981.

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21

Qasim, Faieza Jabeen. "Study of an animal model of experimental vasculitis." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361670.

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22

Dolan, Seamus Joseph. "Endotoxin and proinflammatory cytokines in experimental acute pancreatitis." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263319.

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23

Boyd, Alison Catherine. "Clinical and experimental studies on glycated human insulin." Thesis, University of Ulster, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390153.

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24

Pryce, Gareth. "Cannabinoids for the control of experimental multiple sclerosis." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/673.

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There have been numerous studies reporting that cannabinoids, both exogenous and endogenous, have a potential beneficial function during incidences of neurological damage. Using gene knockout mice and cannabinoid-selective agents, this study demonstrates the diverse actions of cannabinoids with a particular focus on experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. The results presented here report on the action of stimulators of cannabinoid receptors in the nervous system (CNS) on; immune function, as a mechanism of suppressing autoimmune attack of the central

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25

Frith, Daniel. "Clinical & experimental characterisation of acute traumatic coagulopathy." Thesis, Queen Mary, University of London, 2011. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2419.

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Acute traumatic coagulopathy (ATC) is a recently identified entity describing an early impairment of haemostasis after injury. Retrospective observational studies have associated it with a significant increase in patient morbidity and mortality. It does not appear to be caused by conventional mediators of haemorrhagic coagulopathy, such as iatrogenic haemodilution or hypothermia. Rather, it has been postulated that it is endogenous systemic anticoagulation modulated by activation of the protein C pathway in response to shock and tissue injury. The aims of this thesis were to characterise the a

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26

Chamberlain, Lisa M. "Pathogenesis and immunity in experimental infection with Neisseria gonorrhoeae." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320009.

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27

Gardiner, Keith Reginald. "Systemic endotoxaemia in inflammatory bowel disease and experimental colitis." Thesis, Queen's University Belfast, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333776.

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28

Yates, John. "Haemodynamic effects of vasoactive drugs in experimental portal hypertension." Thesis, Liverpool John Moores University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337787.

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29

Docherty, James G. "Local recurrence of colorectal cancer : clinical and experimental studies." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363685.

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Clinical and experimental studies which investigate factors affecting local recurrence of colorectal cancer are detailed. Three hundred and six patients underwent potentially curative surgery and had their anastomosis randomised to either sutures or staples. There was a 7.5% difference in overall recurrence rates in favour of the stapled patients (Log Rank <I>X<sup>2</sup></I>=2.88, 1 df, p=0.09) and there was a similar difference in cancer specific mortality (Log Rank <I>X</I><sup>2</sup>=2.41, 1 df, p=0.12). Anastomotic technique was an independent predictor of both tumour recurrence and can

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30

Ramsay, Jonathan R. "Experimental studies on prediction of response to cancer treatment." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388333.

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31

Zuiderent-Jerak, Teun. "Standardization healthcare practices; experimental interventions in medicine and science and technology studies." [S.l.] : Rotterdam : [The Author] ; Erasmus University [Host], 2007. http://hdl.handle.net/1765/10605.

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32

Bäckman, Ulrika. "Treatment of Experimental Neuroblastoma with Angiogenic Inhibitors." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3536.

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<p>Neuroblastoma is a childhood cancer that originates from neuroblasts in the peripheral nervous system. Neuroblastoma show considerable heterogeneity with respect to location, responsiveness to treatment and prognosis. Since current therapy involves drugs with risk of serious side effects in the growing child, there is a clinical need for more effective and less toxic treatment strategies.</p><p>Angiogenesis, the formation of new blood vessels, is critical for tumor progression. Specific inhibition of tumor-induced angiogenesis should restrict growth of most solid tumors and thereby provide

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33

Nandra, Kiran Kaur. "Novel therapeutic approaches for experimental trauma-haemorrhage." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8470.

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Haemorrhagic shock (HS) is commonly associated with trauma. Severe haemorrhage causes hypoperfusion of tissues resulting in a global ischaemic state, and resuscitation is performed to restore circulating volume. However, the return of oxygen to ischaemic tissues causes the induction of a systemic inflammatory response, which contributes to cell death leading to organ failure. In trauma patients, failure of more than four organs is linked to certain mortality, highlighting the need for interventions that may reduce or prevent the deterioration in organ function. The aim of this thesis was to in

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34

Bertti, Rodolfo Otávio Tomaz 1974. "Modelo experimental de obstrução ureteral em coelhos." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310675.

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Orientadores: Marcelo Lopes de Lima, Carlos Arturo Levi D¿Ancona<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T16:54:01Z (GMT). No. of bitstreams: 1 Bertti_RodolfoOtavioTomaz_M.pdf: 2337476 bytes, checksum: aee22920cef52ff73befdaef0207e2f7 (MD5) Previous issue date: 2011<br>Resumo: A estenose da junção pieloureteral (JUP) é uma das anomalias congênitas mais frequentes. Clinicamente, pode se manifestar por infecção do trato urinário, por dor e pela perda da função renal. Portanto, o estudo desta doença é

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35

Torres, Fabrício Carvalho. "Panículo adiposo interescapular de coelho da espécie Oryctolagus cuniculus como fonte de células-tronco." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/5/5132/tde-31082009-162219/.

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Nos últimos anos, as células-tronco, devido a sua capacidade de originar diversos tecidos corporais e pelo poder de auto-renovação, impulsionaram os estudos de engenharia tecidual, sobretudo em medicina regenerativa. Nesse aspecto, o tecido adiposo vem se mostrando como fonte ideal para obtenção de tais células, devido à facilidade de captação, à baixa morbidade associada ao procedimento e ao elevado rendimento celular. Com o objetivo de estabelecer um modelo experimental versátil e que satisfizesse várias áreas de interesse, propôs-se o coelho Oryctolagus cuniculus como fonte de tecido adipos

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36

Bavetta, Sebastiano. "New methodologies for the treatment of experimental spinal cord injury." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312840.

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37

Harney, B. A. "Investigations of a subunit vaccine in experimental herpes simplex keratitis." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375020.

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38

Lemming, Dag. "Experimental Aspects on Chronic Whiplash-Associated Pain." Doctoral thesis, Linköpings universitet, Rehabiliteringsmedicin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-10693.

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Introduction: Chronic pain after whiplash trauma (chronic WAD) to the neck is still a common clinical problem in terms of pain management, rehabilitation and insurance claims. In contrast to the increased knowledge concerning mechanisms of chronic pain in general, no clinical guidelines exist concerning assessment, pain control and rehabilitation of patients with chronic WAD. Aim: The general aim of this thesis was to use experimental techniques to better understand the complex mechanisms underlying chronic pain after whiplash trauma. The specific aims of papers I and II were mainly to use ana

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39

Aarvold, Alexander. "Bone tissue engineering : experimental strategies and clinical application." Thesis, University of Southampton, 2011. https://eprints.soton.ac.uk/362817/.

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Skeletal stem cell based therapies offer tremendous potential for regeneration of a patient's bone. With the demo graphics of an ageing population, the demand for skeletal reconstruction to replace lost or damaged bone is expanding dramatically. Novel bone tissue engineering techniques offer the opportunity to push the boundaries of bone regeneration, yet few strategies have been translated to clinical practice. This thesis aims to explore novel bone regeneration strategies in vitro and in vivo, and details the clinical application of those techniques. The effects of skeletal stem cells, growt

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40

Neilly, Paul John David. "Inflammatory mediators and amino acid therapy in experimental inflammatory bowel disease." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361291.

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41

Cope, Richard Adrian. "An experimental investigation into the early treatment of life threatening hyperkalaemia." Thesis, King's College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307574.

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42

Morris, Margaret Mary. "Immune-mediated mechanisms of demyelination in experimental models of multiple sclerosis." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299695.

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43

Lin, Wey-Ran. "Tracing cell lineages in health and disease : experimental and human studies." Thesis, Queen Mary, University of London, 2010. http://qmro.qmul.ac.uk/xmlui/handle/123456789/556.

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This study aimed to investigate stem cell biology in the normal and diseased pancreas and liver employing robust methods for tracking stem cells and their progeny in both pre-clinical and human scenario. Bone marrow (BM) plasticity had been demonstrated in diseased organ remodelling. By detection of the Y chromosome in female mice receiving a sexmismatch BM transplantation, BM-derived cells were present in murine pancreas with cerulein-induced pancreatitis. BM-derived myofibroblasts functionally contributed to around 8% of the total population of myofibroblasts, the cells with a key fibrogenic

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44

Neumann, Peter. "Airway pressure release ventilation : a systematic experimental approach /." Uppsala, Sweden : Uppsala University : Distributed by Uppsala University Library, 2000. http://w3.ub.uu.se/diss/eng/abstract.cfm?ISBN=91-554-4723-6.

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45

Rafiei, Abdollah. "Studies on the immunodiagnosis of cystic echinococcosis in experimental and human infections." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360448.

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46

Roberts, Richard Edwards. "Protein kinase C, protein phosporylation, and nerve regeneration in experimental diabetic neuropathy." Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295836.

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47

Gilbert, Angela Doreen. "Inherited variation of host response to experimental periodontal disease in the mouse." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/18905.

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Spencer, Robert F. "The effect of head injury on fracture healing : clinical and experimental studies." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19310.

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49

Winter, Andrew John. "Hearing loss in experimental bacterial meningitis." Thesis, University of Birmingham, 1997. http://etheses.bham.ac.uk//id/eprint/32/.

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Experimental meningitis was induced in pigmented guinea pigs by subarachnoid inoculation of \(1 \times 10^9\) Escherichia coli K-12 or \(3 \times 10^7\) CFU Streptococcus pneumoniae serotype 2 D39 (NCTC 7466) or PLN-A, \(\Delta\)NA1 or \(\Delta\)HY1, defined isogenic derivatives of D39 deficient in pneumolysin, neuraminidase or hyaluronidase respectively. All animals developed a meningeal inflammatory response and a labyrinthitis. Hearing loss in pneumococcal meningitis was measured by recording the evoked auditory nerve compound action potential from the round window membrane. Animals infecte

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50

Jayanth, Aiden Matthew. "Experimental studies on the microbiota associated with urinary tract infections." Thesis, University of Essex, 2017. http://repository.essex.ac.uk/20191/.

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Urinary tract infections (UTIs) are one of the most common healthcare associated infections (HCAIs) accounting for 17.2% of the total HCAI’s in England. Some of the underlying issues associated with UTIs include recurrent infections, catheter associated UTIs and antibiotic resistance. These issues are responsible for prolonged hospital admissions, increased costs and significant morbidity. Another possible issue relates to the ubiquitous protozoa, Acanthamoeba. Although it is known to cause infections in humans, the amoeba has been isolated from apparently healthy people. Furthermore, Acantham

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