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Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Huppes, Rafael Ricardo [UNESP]. "Expressão gênica de MMP-2 e 9, TIMP-1 e 2, ATM, TP53, VEGF, COX-2 e CDH-1 no TVT canino." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/122030.

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Made available in DSpace on 2015-04-09T12:28:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-06-20Bitstream added on 2015-04-09T12:47:47Z : No. of bitstreams: 1 000814346.pdf: 1337951 bytes, checksum: 9ed960afb83960e3296a726e4541f251 (MD5)<br>A literatura cita que 1 a 5% dos casos de tumor venéreo transmissível (TVT) primário são metastáticos. Sendo assim, é importante estudar os mecanismos que colaborem para a invasão metastática assim como para sua implantação. Dentre estes mecanismos as metaloproteinases (MMP-2 e MMP-9) e seus inibidores (TIMP-1 e TIMP-2), assim como o ATM, COX-

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Huppes, Rafael Ricardo. "Expressão gênica de MMP-2 e 9, TIMP-1 e 2, ATM, TP53, VEGF, COX-2 e CDH-1 no TVT canino /." Jaboticabal, 2014. http://hdl.handle.net/11449/122030.

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Orientador: Renée Laufer Amorim<br>Coorientador: Andrigo Barboza De Nardi<br>Coorientador: Mirela Tinucci Costa<br>Banca: Rosemere de Oliveira Vasconcelos<br>Banca: Geórgia Mode Magalhães<br>Banca: Rafael Torres Neto<br>Banca: Bruno Watanabe Minto<br>Resumo: A literatura cita que 1 a 5% dos casos de tumor venéreo transmissível (TVT) primário são metastáticos. Sendo assim, é importante estudar os mecanismos que colaborem para a invasão metastática assim como para sua implantação. Dentre estes mecanismos as metaloproteinases (MMP-2 e MMP-9) e seus inibidores (TIMP-1 e TIMP-2), assim como o ATM,

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Fakler, Hariolf Eugen. "Expression und Funktion von Insulinrezeptor-Substrat (IRS) /-1 und /-2." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-55718.

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Jana, Lisa [Verfasser]. "Expression der Histondeacetylasen 1, 2 und 3 im Mammakarzinom / Lisa Jana." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2013. http://d-nb.info/1042940770/34.

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Watkins, Gemma L. "A comparison of HIV-1 and HIV-2 gag gene expression." Thesis, University of Warwick, 2012. http://wrap.warwick.ac.uk/45902/.

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Despite being closely related viruses with similar replication cycles, HIV-2 replicates more slowly than HIV-1 and produces fewer particles, resulting in a lower plasma viral load. Expression of the major structural gene, gag, from HIV-1 and HIV-2 proviruses was compared to investigate whether this could play a role in the difference in particle production observed between HIV-1 and HIV-2 infection. Using quantitative RT-PCR, significantly less full-length HIV-2 gag mRNA was found to be transcribed from its provirus than for HIV-1. Sub-cellular fractionation allowed us to determine HIV-1/2 gag

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6

Kojima, Masahiro. "Expression of Nedd2/ICH-1(caspase-2)in the developing ratretina." Kyoto University, 1999. http://hdl.handle.net/2433/181729.

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Sun, Xiaoguang, Biji Mathew, Saad Sammani, Jeffrey R. Jacobson, and Joe G. N. Garcia. "Simvastatin-induced sphingosine 1−phosphate receptor 1 expression is KLF2-dependent in human lung endothelial cells." SAGE PUBLICATIONS INC, 2017. http://hdl.handle.net/10150/623874.

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We have demonstrated that simvastatin and sphingosine 1-phosphate (S1P) both attenuate increased vascular permeability in preclinical models of acute respiratory distress syndrome. However, the underlying mechanisms remain unclear. As Kruppel-like factor 2 (KLF2) serves as a critical regulator for cellular stress response in endothelial cells (EC), we hypothesized that simvastatin enhances endothelial barrier function via increasing expression of the barrier-promoting S1P receptor, S1PR1, via a KLF2-dependent mechanism. S1PR1 luciferase reporter promoter activity in human lung artery EC (HPAEC

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8

Tausch, Kathrin. "Expression von Angiopoietin-1 und Angiopoietin-2 im Endometrium und in Endometriosegewebe." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971973113.

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9

Stephens, Bret. "PRL Phosphatases: Expression and Function in Pancreatic Cancer." Diss., The University of Arizona, 2008. http://hdl.handle.net/10150/194846.

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One of the current goals in cancer research is to discover and validate novel molecular targets that may be useful for diagnostic and therapeutic purposes in fighting this disease. The PRL phosphatases (PRL-1, PRL-2, and PRL-3) are low molecular weight protein tyrosine phosphatases with unknown biological function(s) that have gained attention from cancer researchers in the past couple of years, mainly due to reports that these phosphatases may play important roles in tumor progression and metastasis. Motivated by the particular urgent need for molecular targets in pancreatic cancer this work

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10

Meade, Eliza. "Hypoxic Regulation of VEGF and PAI-1 Expression by HIF-1[alpha] and HIF-2[alpha] in First Trimester Trophoblasts." Yale University, 2006. http://ymtdl.med.yale.edu/theses/available/etd-06282006-115727/.

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Preeclampsia results from incomplete trophoblast invasion of the spiral arteries during early pregnancy. Vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) are critical factors involved in angiogenesis, invasion and hemostasis at the maternal-fetal interface. Both factors are transcriptionally regulated by hypoxia inducible factor (HIF), a heterodimeric complex consisting of HIF-1[beta] and either HIF-1[alpha] or -2[alpha] whose specificity or redundancy in gene regulation is cell-type specific. This study uses siRNA technology to dissect the mechanisms of

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11

Laube, Markus. "Synthese von Cyclooxygenase-2-Inhibitoren als Grundlage für die funktionelle Charakterisierung der COX-2-Expression mittels PET." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-160091.

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Eine erhöhte COX-2-Expression wird bei Krankheiten wie rheumatoider Arthritis aber auch Parkinson, Alzheimer und Krebs beobachtet. Die nichtinvasive Visualisierung und Quantifizierung der COX 2-Expression in vivo mittels Positronen-Emissions-Tomographie (PET) könnte wertvolle Beiträge zur Diagnose dieser Krankheiten liefern. Zur Nutzung der PET-Technik werden geeignete COX-2-adressierende Radiotracer benötigt, deren Entwicklung auch die Identifizierung neuer, der Radiomarkierung zugänglicher COX-2-Inhibitoren als Leitstrukturen voraussetzt. Ziel dieser Arbeit war die Synthese von selektiven,

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12

Miller, John Paul. "Picornaviruses as candidate vaccine vectors expression of HIV-1 antigens and examination of the effect of HPeV-1 viral 2BC protein on surface MHC-1 expression /." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872073641&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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13

Maroski, Bastian [Verfasser]. "Zeitliche Expression des Transkriptionsfaktors EGR-1 und der MAP-Kinasen ERK-1/2 in murinen Modellen der viralen Myokarditis / Bastian Maroski." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1113011726/34.

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14

Drenkhahn, Merle. "Expression von Angiopoietin-1 und Angiopoietin-2 im ektopen Endometrium auf der Chorioallantoismembran." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=976803968.

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Marks, Philip M. H. "Expression, purification and characterisation of the novel type I 1/2 methyltransferase M.AhdI." Thesis, University of Portsmouth, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247624.

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16

Babucke, Sarah [Verfasser]. "Untersuchungen zur Expression der Paraoxonasen 1, 2 und 3 in Keratinozyten / Sarah Babucke." Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1020001364/34.

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17

Sun, Haipeng. "Regulation of Cyclooxygenase Gene Expression by Glucocorticoids in Cardiomyocytes." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/194896.

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Glucocorticoids (GCs) are endogenous steroid hormones that regulate a number of critical physiological processes. Psychological stress increases the level of GCs in the circulating system. The biological effect of elevated GCs on the heart is not well understood. We found that GCs induced Cyclooxygenase-1 (COX-1) and COX-2 gene expression in cardiomyocytes. COX-1 or COX-2 encodes the rate-limiting enzyme in the biosynthesis of prostanoids, which modulate crucial physiological and pathophysiological responses. The present studies aim to elucidate the signaling transduction pathway and the

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18

Helterline, Deri Lila Icenoggle. "Embryonic and tissue-specific regulation of myostatin-1 and -2 gene expression in zebrafish." Online access for everyone, 2006. http://www.dissertations.wsu.edu/Thesis/Spring2006/d%5Fhelterline%5F050106.pdf.

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Tuncay, Seda. "Functional Characterization Of 15-lipoxygenase-1 Expression In Human Colorectal Carcinoma Cell Line Ht-29." Master's thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/2/12610807/index.pdf.

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Colorectal carcinoma (CRC) is often lethal when invasion and/or metastasis occur. 15-lipoxygenase-1 (15-LO-1), an enzyme of the inflammatory eicosanoid pathway, oxidatively metabolizes linoleic acid and its expression is repressed in CRC. In the present study, the hypothesis that the lack of 15-LO-1 expression in CRC cells may contribute to the tumorigenesis was investigated. Therefore 15-LO-1 was introduced to colon cancer cell line HT-29 that does not have detectable levels of the 15-LO-1. The HT-29 cells were transiently transfected with the eukaryotic expression vector pcDNA3.1-15-LO-1 and

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20

Spens, Antje. "Expression der Matrixmetalloproteasen (MMP-2 und MMP-9) und ihrer Inhibitoren (TIMP-1 und TIMP-2) in humanen Schilddrüsengeweben." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=961767618.

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Wilhelm, Margareta. "The p53-induced gene wig-1 : regulation of expression and role in embryonic development /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-728-2.

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22

Cottignoli, Stefano <1979&gt. "Expression and cellular localization of Copper transporter 2 (Ctr2) in Mus musculus." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/1883/1/Cottignoli_Stefano_tesi.pdf.

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The Ctr family is an essential part of the copper homeostasis machinery and its members share sequence homology and structural and functional features. Higher eukaryotes express two members of this family Ctr1 and Ctr2. Numerous structural and functional studies are available for Ctr1, the only high affinity Cu(I) transporter thus far identified. Ctr1 holigotrimers mediate cellular copper uptake and this protein was demonstrated to be essential for embryonic development and to play a crucial role in dietary copper acquisition. Instead very little is known about Ctr2, it bears structural h

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23

Weise, Sebastian. "Einfluss von Interleukin-1 beta auf die Expression und Sekretion der Adipokine TIMP-1, SAA-3, Lipocalin-2 und Chemerin in 3T3-L1 Adipozyten." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-106754.

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Adipositas und ihre Folgeerkrankungen stellen eine wachsende medizinische Herausforde- rung globalen Ausmaßes dar. Im Rahmen der Adipositasforschung wurde das Fettgewebe als endokrines Organ identifiziert. Von ihm sezernierte Proteine, die sogenannten Adipo- kine, beeinflussen maßgeblich Insulinresistenz und Gefäßverletzbarkeit. Adipositas geht im Fettgewebe mit einer subklinischen chronischen Entzündung einher, die zu einer erhöhten Sekretion von proinflammatorischen Adipokinen führt. Die verstärkte Anwesenheit dieser Proteine ist mit den Komplikationen der Adipositas assoziiert. Die vorliege

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24

Siyahian, Arpi J. "PTH and Nurr 1 mediated gene expression in osteoblasts." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1905636831&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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Salonurmi, T. (Tuire). "Cell lineage specific expression of matrix metalloproteinases -2 and -9 in transgenic mice." Doctoral thesis, University of Oulu, 2004. http://urn.fi/urn:isbn:9514273540.

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Abstract Mammalian extracellular matrix metalloproteinases, MMPs, are a family of enzymes capable of degrading components of the connective tissue. The in vivo regulation of the cell lineage-specific expression of MMPs, however, is not well known. This study used transgenic mice to identify cell-specific elements in the upstream regulatory regions of MMP-2 and MMP-9. Transgenic mice were generated by pronuclear microinjections into fertilised oocytes using lacZ as a reporter gene. The reporter gene constructs containing varying lengths of the MMP-9 5'-upstream region revealed an area that allo

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Moser, Christiane. "Klonierung und funktionelle Expression des humanen Y 5 -Rezeptors in HEC-1-B-Zellen : Pharmakologische Untersuchungen zur Neuropeptid Y Y 1-2-, Y 2 - und Y 5 -Rezeptorselektivität peptidischer und nichtpeptidischer Liganden /." [S.l. : s.n.], 1999. http://www.gbv.de/dms/bs/toc/311941680.pdf.

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Pears, C. J. "Cysteine proteinase 2 : structure and expression of a developmentally regulated gene of Dictyostelium discoideum." Thesis, Imperial College London, 1987. http://hdl.handle.net/10044/1/47615.

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Drwal, Veronika [Verfasser], and Thomas [Akademischer Betreuer] Wex. "Die Bedeutung der Expression der G-Protein-gekoppelten-Rezeptoren BRS 3, CCKA, CXCR 4, GHRH, GRPR, NK 1, NMBR, NT 2, PAC 1, VPAC 1 und VPAC 2 bei kolorektalen Tumoren in Abhängigkeit von Tumorstadium und Differenzierungsgrad / Veronika Drwal. Betreuer: Thomas Wex." Magdeburg : Universitätsbibliothek, 2012. http://d-nb.info/1054135525/34.

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Mokgokong, Ruth Nontuthuzelo. "Anion exchanger 2 and sodium-hydrogen exchanger 1 expression and function in rat brain endothelial cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609347.

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Sullivan, Amy Lynn. "Regulation of gene expression programs by serum response factor and megakaryoblastic leukemia 1/2 in macrophages." Diss., [La Jolla] : University of California, San Diego, 2009. http://wwwlib.umi.com/cr/ucsd/fullcit?p3386598.

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Thesis (Ph. D.)--University of California, San Diego, 2009.<br>Title from first page of PDF file (viewed Jan. 14, 2010). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 97-114).

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Orwig, Nathane. "Factors regulating KiSS-1 and GPR54 expression in the hippocampus /." Available to subscribers only, 2007. http://proquest.umi.com/pqdweb?did=1400960131&sid=14&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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Venkitaraman, Ashok Ramakrishnan. "The regulation of MHC class 2 gene expression by tumours of the B lymphocyte lineage." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47696.

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33

Almqvist, Jenny. "Epstein-Barr virus nuclear antigen 1, Oct & Groucho/TLE in control of promoter regulation /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-523-2/.

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Hänsel, Laura [Verfasser]. "Suppression der kardialen Phosphatidat Phosphohydrolase 1 Aktivität und Lipin 1 mRNA Expression in Zucker diabetic fatty Ratten und Patienten mit Diabetes mellitus Typ 2 / Laura Hänsel." Lübeck : Zentrale Hochschulbibliothek Lübeck, 2017. http://d-nb.info/1132085985/34.

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Spengler, Joseph R. "Diabetes-Induced Expression and Regulation of GLP-1 levels by Bile Acid Receptors (TGR5 & FXR)." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4776.

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Diabetes Mellitus has continued to drastically affect the health of the world and many complications can prove fatal. As long as this metabolic disease persist, research discoveries will need to continue to be made so that patient outcomes and healthcare are dramatically enhanced. In recent years, GLP-1 has been the topic of conversation for diabetes research, due to its promising effects in promoting insulin sensitivity. Furthermore, bile acids and their receptors (TGR5 & FXR) have shown promise in their actions in the regulation of GLP-1, and thus glucose homeostasis. Here we have shown the

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36

Vaalamo, Maarit. "Matrix metalloproteinases and their inhibitors in normal and aberrant wound repair : expression patterns of collagenases-1 and -3, stromelysins-1 and -2, matrilysin, metalloelastase and TIMPs-1, -2, -3 and -4 in healing cutaneous wounds and in chrome ulcers of the skin and the intestine." Helsinki : University of Helsinki, 2000. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/vaalamo/.

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Vakil, Priyal R. "Expression and Clinicopathological Implications of the Vitamin C Transporters SVCT-1 and SVCT-2 in Colon Cancer." Thesis, University of the Sciences in Philadelphia, 2019. http://pqdtopen.proquest.com/#viewpdf?dispub=13860024.

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<p> Most of the colon cancer patient tumors progress to metastases, despite undergoing surgical resection or adjuvant chemotherapy. Predicting which patients will progress to metastases has been extremely challenging. There is an urgent need to identify early novel prognostic biomarkers that can early on predict the patient outcome. Vitamin C has been shown to have a pro-oxidant effect on cancer that enhances tumor growth and survival. Vitamin C is transported into mammalian cells via two isoforms of sodium-dependent vitamin C transporters (SVCTs), SVCT1 and SVCT2. The expression and clinical

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Ishikawa, Seiji. "Increased Expression of Phosphatidylcholine (16:0/18:1) and (16:0/18:2) in Thyroid Papillary Cancer." Kyoto University, 2014. http://hdl.handle.net/2433/188670.

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Beiche, Alexandra. "Expression von Caspasen in Kopf-Hals-Tumoren - immunhistochemischer Nachweis von Caspase 1, 2, 3 und Proliferationsmarker Ki67." Ulm : Universität Ulm, Medizinische Fakultät, 2000. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB9186905.

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Sui, Feng-Tsai, and 隋風采. "Expression of MMP-1,-2,-9 and TIMP-1,-2 in liver fibrosis and Expression of MMP-1,-2,-9 and TIMP-1,-2 in liver fibrosis and cirrhosis." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/70916687958195584844.

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碩士<br>臺北醫學大學<br>醫學技術學系<br>93<br>Chronic viral hepatitis is a global health problem. It is usually clinically silent but may undergo persistent hepatic inflammation and progressive fibrosis, which lead to liver cirrhosis and hepatocellular carcinoma (HCC) in about 20-30 % of patients. Because patients with advanced cirrhosis carry a grave long-term prognosis, early diagnosis of liver fibrosis and early cirrhosis is of paramount importance. Hepatic extracellular matrix (ECM), which is secreted by hepatic stellate cells (HSC), plays an important role in the hepatic fibrogenesis. We concomitantly

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Youreva, Viktoria. "Early growth response protein 1 (Egr-1) expression by Insulin-like growth factor 1 (IGF-1) involves MAPKs and PKB pathways." Thèse, 2014. http://hdl.handle.net/1866/12771.

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Un remodelage vasculaire anormal est à la base de la pathogenèse des maladies cardio-vasculaires (MCV) telles que l’athérosclérose et l’hypertension. Des dysfonctionnements au niveau de la migration, l’hypertrophie et la prolifération des cellules musculaires lisses vasculaires (CMLV) sont des évènements cellulaires qui jouent un rôle primordial dans le remodelage vasculaire. L’insulin-like growth factor 1 (IGF-1), puissant facteur mitogène, contribue au développement des MCV, notamment via l’activation des protéines MAPK et PI3-K/PKB, composantes clés impliquées dans les voies de crois

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42

Flagg, Angela Sally. "The expression of interleukin-1 receptor type 1 and 11 in monocytes and myelocytic leukaemic cells." Thesis, 1996. https://hdl.handle.net/10539/24509.

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A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg for the Degree of Master of Science<br>The antiinflammatory effects of lnterleukin-4 (IL-4) and the synthetic glucocorticoid dexamethasone were studied in adhered monocytes and the leukaemic cells HL-60 and THP-1, with respect to the expression of interleukin-lB (IL-lLB), the (signalling) IL-1 receptor type I (IL..1RtI), and the (inhibitory) IL-1 receptor type I (IL-lRtI). (Abbreviation abstract)<br>AC2018

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Scharschinger, Anette. "Expression und Aktivität der Phospholipase-2 und der Cyclooxygenase-1 und -2 in Kolonkarzinomzellen /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013060459&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Chia, Ting-Wen, та 賈婷文. "Docosahexaenoic acid inhibits TNFα-induced ICAM-1 expression via binding to GRP120 and down-regulation of ERK-1/2-dependent Egr-1 expression in EA.hy926 cells". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/32075589428244180223.

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碩士<br>中國醫藥大學<br>營養學系碩士班<br>101<br>Background and objectives: Tumor necrosis factor-alpha (TNFα), a potent inflammatory mediator, has multiple effects on the pathogenesis of atherosclerosis. Early growth response-1 (Egr-1), a zinc finger transcription factor, participates in cell growth and differentiation. In recent years, Egr-1 has emerged as a key regulator in the development of atherosclerosis. Docosahexaenoic acid (DHA), an omega-3 fatty acid (n-3 FA), has potent anti-inflammatory effect. It has been demonstrated that G protein-coupled receptor 120 (GPR120) functions as an n-3 FA receptor.

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Rodrigues, Natália. "Expression of cyclooxygenase isoforms in equine gastric ulcers." Thèse, 2009. http://hdl.handle.net/1866/7178.

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Königshausen, Matthias. "Untersuchung der PD-1/PDL-1/PDL-2 Expression und infiltrierender T-Zellen im humanen kolorektalen Karzinom und ihre Auswirkung auf die Immunantwort." Doctoral thesis, 2007. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-24844.

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Zusammenfassung Neueste Daten deuten daraufhin, dass maligne Tumoren der immunologischen Überwachung über eine Herunterregulierung der T-Zell-Aktivierung mittels eines PD-1 (programmed death 1)/ PDL-1/PDL-2 Signals ausweichen. Dies führt offensichtlich zu einer herabgesetzten Immunantwort und kann somit das Tumorwachstum fördern. Das Oberflächenmolekül PD-1, welches auf T- und B-Zellen, myeloischen Zellen und auf vielen menschlichen Karzinomen exprimiert wird, gehört zu der CD28 Familie, und PDL-1 (B7H1) und PDL-2 (B7DC) wurden als Liganden zu PD-1 beschrieben. Der CD28/B7 Signalweg gehört zu

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Dimova, Elitsa Yosifova. "Transcriptional Regulation of human Plasminogen Activator Inhibitor-1 Gene Expression by Insulin-like Growth Factor-1, Insulin and Upstream Stimulatory Factor-2." Doctoral thesis, 2005. http://hdl.handle.net/11858/00-1735-0000-0006-AB9F-7.

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Chi-Shan and 蔡奇珊. "Differential Expression and function of the IGF-1 receptor,IRS-1 and IRS-2 in Lung Cancer Cell Lines." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/41769962322689787608.

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碩士<br>中山醫學大學<br>免疫學研究所<br>98<br>Lung cancer is the leading cause of cancer death worldwide. The high mortality of lung cancer is due to metastasis and resistance to chemotherapy. Insulin-like growth factor (IGF-I) is a pleiotropic growth factor with potent mitogenic and anti-apoptotic functions. It initiates cascades of signaling by inducing tyrosine phosphorylation of the IGF-I receptor (IGF-IR). The active receptor then recruits and phosphorylates the IRS and Shc. IRS protein contains multiple tyrosine residues, which serves as docking sites for various signaling molecules including phosphat

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Lai, Szu-Chai, and 賴思嘉. "Mechanisms of Endothelin-1-induced COX-2 Expression in Osteoblast MC3T3 cells." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/48214439014294292334.

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碩士<br>長庚大學<br>基礎醫學研究所<br>96<br>Abstract Mature bone homeostasis is maintained by bone remodeling cycle involved in osteoblast bone formation and osteoclast bone resorption. Under physiological conditions, the bone matrix is constantly renewed with bone remodeling to restructure itself in response to stimulation. Endothelin-1(ET-1), a potent vasoconstrictor, has been shown to be a pro-inflammatory cytokine like TNF- and IL-1β. ET-1 may cause a variety of inflammatory diseases, including airway inflammation, cutaneous inflammation, Crohn’s disease, ulcerative colitis, and liver cirrhosis. Under

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von, Fintel Hendrik. "Einfluss von Transforming Growth Factor - beta 1 (TGF-β1) und Hypoxie auf die Expression von Sulfattransportern (SAT-1 und NaSi-1) in den humanen renalen Zelllinien TK173 und TK188". Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B219-2.

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