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Rozprawy doktorskie na temat „Extracellular matrix (ECM) peptides”

Autor: Grafiati

Data publikacji: 30 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

Maayouf, Hasna. "Développement de plateformes de signalisation dérivées de particules pseudo-virales pour contrôler les fonctions cellulaires." Electronic Thesis or Diss., Mulhouse, 2024. http://www.theses.fr/2024MULH7387.

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Diverses stratégies de fonctionnalisation de surface visent à améliorer la biocompatibilité des matériaux pour les dispositifs implantables, notamment en ingénierie tissulaire. Par exemple, le polydiméthylsiloxane (PDMS), bien qu’utilisé dans de nombreux domaines, présente des propriétés de surface défavorables à l’adhérence cellulaire. La fonctionnalisation par des protéines de la matrice extracellulaire (MEC) ou des peptides synthétiques dérivés de celles-ci permet d’améliorer l'adhérence des cellules. Bien que ces approches offrent certaines solutions, des défis tels que le coût de producti

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Kammerer, Theresa Anne [Verfasser], and Sebastian Johannes [Akademischer Betreuer] Arnold. "Visualization of the Extracellular Matrix (ECM) by fluorescent tagging of ECM components in mouse." Freiburg : Universität, 2021. http://d-nb.info/1232644803/34.

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Randles, Michael. "Proteomic analyses of kidney glomerular extracellular matrix in health and disease." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/proteomic-analyses-of-kidney-glomerular-extracellular-matrix-in-health-and-disease(a39fe408-db06-4d80-b97b-4e0651bf7bc3).html.

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Glomerular filtration is a vital physiological process removing waste products from the circulation and this process occurs across the glomerular filtration barrier (GFB). The cells and extracellular matrix (ECM), which form this barrier, are exposed to forces during ultrafiltration and special adaptation is required to withstand these forces. Dysfunction in cellular adhesion machinery or ECM assembly within the GFB causes loss of selective glomerular filtration, however, the mechanisms governing these processes are poorly understood. To this end we sought to characterise the glomerular ECM an

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Marengo, Kaitlyn A. "The Incorporation of Decellularized Cardiac ECM into Fibrin Microthreads." Digital WPI, 2017. https://digitalcommons.wpi.edu/etd-theses/843.

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Stem cell therapies have shown promising capabilities in regaining the functionality of scar tissue following a myocardial infarction. Biological sutures composed of fibrin have been shown to more effectively deliver human mesenchymal stem cells (hMSCs) to the heart when compared to traditional cell delivery mechanisms. While the biological sutures do show promise, improvements can be made. To enhance the fibrin sutures, we propose to incorporate native cardiac extracellular matrix (ECM) into the fibrin microthreads to produce a more in vivo-like environment. This project investigated the effe

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Villaggio, Giusy. "Relationship between extracellular matrix (ECM) components and mineralization in bone marrow stromal cells." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1492.

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The relations between cells and extracellular matrix seem to orchestrate tissue organization by regulating cell functions during fetal development and throughout normal adult life. Thus, focusing on the innate ability of the native ECM to better modulate cell behavior, the coating of synthetic biomaterials with cell-derived decellularized extracellular matrices is a promising approach to confer bioactivity to inert materials and direct the fate of host or transplanted cells in tissue engineering applications. This study aims to better understand ECM influence on human bone marrow stem cells an

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6

Kwak, Hyo Bum. "Exercise training regulation of extracellular matrix and remodeling in the aging rat heart." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2761.

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McKenna, Declan Joseph. "Studies of the 67 kilodalton laminin receptor in retinal vasculature." Thesis, Queen's University Belfast, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300777.

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8

Singh, Mahipal, Cerrone R. Foster, Suman Dalal, and Krishna Singh. "Osteopontin: Role in Extracellular Matrix Deposition and Myocardial Remodeling Post-MI." Digital Commons @ East Tennessee State University, 2010. https://dc.etsu.edu/etsu-works/8576.

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Remodeling after myocardial infarction (MI) associates with left ventricular (LV) dilation, decreased cardiac function and increased mortality. The dynamic synthesis and breakdown of extracellular matrix (ECM) proteins play a significant role in myocardial remodeling post-MI. Expression of osteopontin (OPN) increases in the heart post-MI. Evidence has been provided that lack of OPN induces LV dilation which associates with decreased collagen synthesis and deposition. Inhibition of matrix metalloproteinases, key players in ECM remodeling process post-MI, increased ECM deposition (fibrosis) and

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9

Brian, Irene. "Crosstalk between ECM mechanical cues and cellular metabolism." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422721.

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Mechanical cues coming from the extracellular matrix (ECM) are key factors in the control of tissue homeostasis in physiology and disease. Cells can sense these physical cues and measure external resisting forces by adjusting their actomyosin cytoskeleton, which in turn regulates intracellular signalling pathways to orchestrate a proper cell response. Thus, ECM stiffness is important for many biological aspects such as proliferation, differentiation and migration. Very little is known instead, about its impact on cellular metabolism, and the molecular players involved in this process are large

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10

Bilem, Ibrahim. "Micro-engineered substrates as bone extracellular matrix mimics." Doctoral thesis, Université Laval, 2016. http://hdl.handle.net/20.500.11794/27329.

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Il est de plus en plus évident que la matrice extracellulaire (MEC), au-delà de sa fonction d’échafaudage cellulaire, génère des signaux de nature biochimique et biophysique jouant un rôle primordial au cours du processus de différenciation des cellules souches. A l’heure actuelle, plus de 15 différents facteurs extrinsèques (environnementaux), incluant l’organisation spatiale de la MEC, sa topographie, rigidité, porosité, biodégradabilité et chimie ont été identifiés comme modulateurs potentiels de la différenciation des cellules souches en lignées cellulaires spécialisées. Ainsi, il est plau

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11

Siu, Kwan-yee Michelle, and 蕭君兒. "How do components of the extracellular matrix (ECM) regulate junction dynamics in the testis and their implication in contraceptivedevelopment?" Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31244749.

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Kuroda, Mito. "Mechanism of the ECM stiffness-dependent differentiation of mesenchymal stem cells." Kyoto University, 2018. http://hdl.handle.net/2433/232360.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第21159号<br>農博第2285号<br>新制||農||1060(附属図書館)<br>学位論文||H30||N5133(農学部図書室)<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授植田和光, 教授阪井康能, 教授矢﨑一史<br>学位規則第4条第1項該当

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13

Gnanasambandam, Bhargavee. "Design of Modified Traction Force Microscopy for Cell Response to De Novo ECM." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1591698756910799.

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14

Chin, LiKang. "Tyramine Substituted-Hyaluronan Enriched Fascia for Rotator Cuff Tendon Repair." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1291410773.

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15

Jones, Caitlin. "Stromal PTEN Expression Regulates Extracellular Matrix Deposition and Organization in the Mammary Gland." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1585750384613682.

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16

Pershouse, David A. "Effect of decellularisation methods on methacryloyl-substituted placental ECM hydrogels." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/201712/1/David_Pershouse_Thesis.pdf.

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Biomedical research uses hydrogels for cell culture to closely mimic cellular environments and produce more accurate results than traditional methods. Here, human placenta, a tissue rich in bio-signalling molecules, is used as a base material to create a novel type of hydrogel that can be cured by exposure to visible light (Placental-Methacryloyl; PlacMA). Effects of different preparation methods are explored while mechanical, chemical and biological properties of PlacMA are investigated. PlacMA was found to be highly tuneable and suitable for a variety of cell culture and tissue engineering a

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17

Burrows, Mariana Carvalho. "Evaluation of electrospun PLLA-ECM scaffolds as biomaterials for bone regeneration." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/46/46136/tde-14092016-090552/.

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The extracellular matrix (ECM) is secreted by the host tissue and is an important key for mechanisms of cell responses. The main properties of the ECM materials include biodegradability, biocompatibility, and nanostructured in a 3D fibre network. In addition, ECM is composed of important molecules like growth factors, glycosaminoglycans (GAGs), collagens, fibronectin, and lamin, while final composition depends on the native tissue. We have selected for this study ECMs from cortical bone (B-ECM) and pericardium (P-ECM) tissue. These ECMs were digested by collagenase, pepsin and trypsin. Each of

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18

Alamein, Mohammad A. "Guiding Stem Cells for Tissue and Organ Engineering: Clinical Grade Nanofiber Electrospinning for Recreation of the Optimal 3-Dimensional Extracellular Niche to Control Cellular Fate." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/367480.

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We aimed to provide optimal and controlled growth mechanisms that determine the fate of cells by designing a novel polymeric, bio-functionalised 3-dimensional artificial Nanofibrous Extracellular Matrix (NF-ECM) that recapitulates the natural microenvironment of cells. We initially reviewed current cell-expansion methods, and clinically feasible protocols for tissue engineering applications. They are often based on conventional 2-dimensional tissue culture plates that usually require xenogenic coating substrates or feeder-cells to maintain their characteristics. Propagating cells in a 3-dimens

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19

Antoine, Elizabeth Elena. "Mechanics and transport characterization of bioengineered tissue microenvironment platforms." Diss., Virginia Tech, 2004. http://hdl.handle.net/10919/56954.

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The tissue microenvironment is a complex living system containing heterogeneous mechanical and biophysical cues. Cellular components are surrounded by extracellular matrix and interstitial fluid, while transport of nutrients and biochemical factors is achieved via the vasculature. Each constituent of the tissue microenvironment can play a significant role in its ability to function normally. Many diseases including cancer have been linked with dysfunction in the tissue microenvironment; therefore an improved understanding of interaction between components of this complex system is needed. In

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Antoine, Elizabeth E. "Mechanics and transport characterization of bioengineered tissue microenvironment platforms." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/56954.

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The tissue microenvironment is a complex living system containing heterogeneous mechanical and biophysical cues. Cellular components are surrounded by extracellular matrix and interstitial fluid, while transport of nutrients and biochemical factors is achieved via the vasculature. Each constituent of the tissue microenvironment can play a significant role in its ability to function normally. Many diseases including cancer have been linked with dysfunction in the tissue microenvironment; therefore an improved understanding of interaction between components of this complex system is needed. I

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21

Vogel, Sarah, Simon Arnoldini, Stephanie Möller, Ute Hempel, and Matthias Schnabelrauch. "Sulfated hyaluronan alters fibronectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-221028.

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Extracellular matrix (ECM) composition and structural integrity is one of many factors that influence cellular differentiation. Fibronectin (FN) which is in many tissues the most abundant ECM protein forms a unique fibrillary network. FN homes several binding sites for sulfated glycosaminoglycans (sGAG), such as heparin (Hep), which was previously shown to influence FN conformation and protein binding. Synthetically sulfated hyaluronan derivatives (sHA) can serve as model molecules with a well characterized sulfation pattern to study sGAG-FN interaction. Here is shown that the low-sulfated sHA

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22

Ndreu, Albana. "Electrospun Nanofibrous Scaffolds For Tissue Engineering." Master's thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/12608226/index.pdf.

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In this study a microbial polyester, poly(3-hydroxybutyrate-co-3- hydroxyvalerate) (PHBV), and its blends were wet or electrospun into fibrous scaffolds for tissue engineering. Wet spun fiber diameters were in the low micrometer range (10-50 &amp<br>#956<br>m). The polymer concentration and the stirring rate affected the properties the most. The optimum concentration was determined as 15% (w/v). Electrospun fiber diameters, however, were thinner. Solution viscosity, potential, distance between the syringe tip and the collector, and polymer type affected the morphology and the thickness of bead

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23

Foulcer, Simon. "Structural and functional studies on the G1 domain of human versican." Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/structural-and-functional-studies-on-the-g1-domain-of-human-versican(2670c4da-7050-4280-8a7c-fc02ab3e8bb3).html.

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The chondroitin sulphate proteoglycan (CSPG) versican forms complexes with hyaluronan (HA), which are essential in a range of functions including cellular proliferation and migration. Four isoforms of versican result from alternative splicing. Furthermore, biological roles have been identified for the proteolytic cleavage product of versican which contains the N-terminal G1 hyaluronan binding domain. All of these versican forms have different tightly regulated tissue expression profiles. Consequently, impaired regulation is associated with a number of disease pathologies. For example the large

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Vogel, Sarah, Simon Arnoldini, Stephanie Möller, Ute Hempel, and Matthias Schnabelrauch. "Sulfated hyaluronan alters fibronectin matrix assembly and promotes osteogenic differentiation of human bone marrow stromal cells." Nature Publishing Group, 2016. https://tud.qucosa.de/id/qucosa%3A29174.

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Extracellular matrix (ECM) composition and structural integrity is one of many factors that influence cellular differentiation. Fibronectin (FN) which is in many tissues the most abundant ECM protein forms a unique fibrillary network. FN homes several binding sites for sulfated glycosaminoglycans (sGAG), such as heparin (Hep), which was previously shown to influence FN conformation and protein binding. Synthetically sulfated hyaluronan derivatives (sHA) can serve as model molecules with a well characterized sulfation pattern to study sGAG-FN interaction. Here is shown that the low-sulfated sHA

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25

Hansen, Ryan. "Functional and Structural Analysis of Decellularized Liver Tissue Matrix, with Potential Applications in Cancer Tissue Engineering." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1498650461817088.

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Kuaha, Kunnika. "Environments for zonal cartilage tissue engineering." Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/81992/1/Kunnika_Kuaha_Thesis.pdf.

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Articular cartilage is a highly organized tissue with cellular and matrix properties that vary with depth zones. Regenerating this zonal organization has proven difficult in tissue-engineered cartilage to treat damaged cartilage. In this thesis, we evaluated the effects of culture environments that mimic aspects of the native cartilage environment on chondrocyte subpopulations. We found that decellularized cartilage matrix can improve zonal tissue-engineered cartilage. Also, chondrocytes respond to signals from bone cells and compressive stimulation in a zone-dependent manner. These results hi

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Shelper, Todd Benjamin. "Exploring Morphology and Drug Interactions in Pancreatic Cancer with 3D Cell Culture." Thesis, Griffith University, 2014. http://hdl.handle.net/10072/367976.

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Pancreatic cancer continues to have one of the poorest prognoses amongst all cancers, with a 95% mortality rate. Standard of care chemotherapy has failed to provide significant clinical benefits, which has led to the development of targeted agents against validated signalling pathways. However, to date the approach of targeted agents alone, or in combination with traditional chemotherapeutics, has failed to significantly improve the prognosis for pancreatic cancer patients. The current standard of care chemotherapy for advanced pancreatic cancer provides only a modest increase in survival of s

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Marumoto, Ariane. "Complexo Quinômico envolvido com adaptação de osteoblasto em scaffold orgânico sob condição de diferenciação celular." Botucatu, 2016. http://hdl.handle.net/11449/143761.

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Orientador: Willian Fernando Zambuzzi<br>Resumo: Modelos in vitro têm facilitado a análise da fisiologia celular sob condições experimentais diversas; trata-se de modelo alternativo ao uso de animais de experimentação, que vem sendo difundido e aceito amplamente em pesquisa científica. Além disso, estes modelos têm levado à avanços significativos na compreensão das interações mútuas e adaptativas entre células e substratos. Neste trabalho, nosso objetivo foi analisar eventos moleculares responsáveis pela adaptação de preosteoblastos em substrato orgânico composto por componentes da Matriz Extr

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Genové, Corominas Elsa. "Self-assembling peptide scaffolds as extracellular matrix analogs and their application in tissue engineering and regenerative biology." Doctoral thesis, Universitat Ramon Llull, 2007. http://hdl.handle.net/10803/9308.

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En aquesta Tesi, un nou biomaterial de disseny composat per seqüències peptídiques repetitives i amfifíliques, que per autoensamblatge forma xarxes de nanofibres (i hidrogels), AcN-RADARADARADARADA-CONH2, s´ha utilitzat com a anàleg de la matriu extracel·lular per al manteniment, proliferació i diferenciació cel·lular. Aquest pèptid s'ha funcionalititzat amb motius biològicament actius procedents de proteïnes de la matriu extracel·lular incloent laminina-1 i colàgen IV. El scaffold peptídic autoensamblant RAD16-I i els seus derivats biològicament actius s´han caracteritzat i provat utilitzant

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McCosker, Helen Clare. "Prognostic significance of IGF and ECM induced signalling proteins in breast cancer patients." Thesis, Queensland University of Technology, 2012. https://eprints.qut.edu.au/53580/1/Helen_McCosker_Thesis.pdf.

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Breast cancer is a leading contributor to the burden of disease in Australia. Fortunately, the recent introduction of diverse therapeutic strategies have improved the survival outcome for many women. Despite this, the clinical management of breast cancer remains problematic as not all approaches are sufficiently sophisticated to take into account the heterogeneity of this disease and are unable to predict disease progression, in particular, metastasis. As such, women with good prognostic outcomes are exposed to the side effects of therapies without added benefit. Furthermore, women with aggres

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Patel, Dhaval Pradipkumar. "Novel PEG-elastin copolymer for tissue engineered vascular grafts." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45811.

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The growing incidences of coronary artery bypass graft surgeries have triggered a need to engineer a viable small diameter blood vessel substitute. An ideal tissue engineered vascular graft should mimic the microenvironment of a native blood vessel, while providing the adequate compliance post-implantation. Current vascular graft technologies lack the ability to promote vascular ECM deposition, leading to a compliance mismatch and ultimately, graft failure. Hence, in order to engineer suitable vascular grafts, this thesis describes the synthesis and characterization of novel elastin mimetic pe

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Bohlmann, Lisa Angela. "An Investigation Into a Microbial β-Glucuronidase". Thesis, Griffith University, 2015. http://hdl.handle.net/10072/365554.

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Glycosaminoglycans (GAGs) are the most prevalent hetero-polysaccharides in the body. They are usually attached to a protein core, forming proteoglycans (PGs). PGs play crucial roles in a wide range of biological processes including cell growth, migration and differentiation. Heparan sulfate proteoglycans (HSPGs) are found in the basement membrane and the extracellular matrix (ECM), which surrounds cells and is formed by a network of fibrous proteins, glycoproteins and proteoglycans. In mammalian cells heparan sulfate (HS) is cleaved by a single β-glucuronidase: heparanase. Cleavage of HS-ch

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33

Stamov, Dimitar. "Structural Analysis of Reconstituted Collagen Type I - Heparin Cofibrils." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-27628.

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Synthetic biomaterials are constantly being developed and play central roles in contemporary strategies in regenerative medicine and tissue engineering as artificial extracellular microenvironments. Such scaffolds provide 2D- and 3D-support for interaction with cells and thus convey spatial and temporal control over their function and multicellular processes, such as differentiation and morphogenesis. A model fibrillar system with tunable viscoelastic properties, comprised of 2 native ECM components like collagen type I and the GAG heparin, is presented here. Although the individual components

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34

Carvalho, Linda Christian Carrijo. "LOPAP (Lonomia obliqua prothrombin activator protease): clonagem e expressão em levedura Pichia pastoris, obtenção de um peptídeo sintético, análise estrutural e avaliação de suas potenciais aplicações." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-11022010-104758/.

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O Lopap é um ativador de protrombina da lagarta L. obliqua, pertence à família das lipocalinas e apresenta atividade antiapoptótica. O Lopap foi obtido na forma recombinante (rLopap), na levedura P. pastoris, por metodologia escalonável, e sua atividade foi avaliada in vitro e in vivo. O tratamento com rLopap reduziu o tempo de sangramento em animais anticoagulados com enoxaparina. Por outro lado, um peptídeo derivado do Lopap, designado antiapoptotic peptide (AP), foi capaz de induzir a síntese de colágeno em cultura de fibroblastos e na derme de animais. A região correspondente a AP apresent

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35

Stamov, Dimitar. "Structural Analysis of Reconstituted Collagen Type I - Heparin Cofibrils." Doctoral thesis, Leibniz Institute of Polymer Research Dresden, 2009. https://tud.qucosa.de/id/qucosa%3A25265.

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Synthetic biomaterials are constantly being developed and play central roles in contemporary strategies in regenerative medicine and tissue engineering as artificial extracellular microenvironments. Such scaffolds provide 2D- and 3D-support for interaction with cells and thus convey spatial and temporal control over their function and multicellular processes, such as differentiation and morphogenesis. A model fibrillar system with tunable viscoelastic properties, comprised of 2 native ECM components like collagen type I and the GAG heparin, is presented here. Although the individual components

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Siqueira, Adriane Sousa de. "Peptídeo C16, derivado da laminina, regula invasão, dinâmica de formação e atividade de invadopódios em linhagens celulares de carcinoma epidermóide e fibrossarcoma." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-24092014-154312/.

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A laminina contém peptídeos que podem ser liberados por proteólise. Nosso laboratório estuda os efeitos de peptídeos da laminina em biologia tumoral. Neste trabalho, verificamos se C16 (cadeia g1) estimularia invasão e atividade de invadopódios em células de carcinoma epidermóide (CAL27) e fibrossarcoma (HT1080). C16 promoveu aumento na taxa de invasão e atividade de invadopódios em ambas às linhagens celulares, comparado ao peptídeo controle C16SX. Microscopia em time-lapse demonstrou que C16 induz aumento na atividade de invadopódios em função do tempo. C16 estimula fosforilação de Src e ERK

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Manrique-Castaño, Daniel [Verfasser], Dirk Matthias [Gutachter] Hermann, Patrik [Gutachter] Krieger, and Tracy D. [Gutachter] Farr. "Influence of the extracellular matrix protein Tenascin-C in the immune response, glial scar formation and ECM reorganization following cerebral ischemia in mice / Daniel Manrique-Castaño ; Gutachter: Dirk Matthias Hermann, Patrik Krieger, Tracy D. Farr ; International Graduate School of Neuroscience." Bochum : Ruhr-Universität Bochum, 2020. http://d-nb.info/1223176096/34.

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Simmers, Phillip Charles. "Benefits of Nitric Oxide Cues to Matrix Synthesis by Healthy and Aneurysmal Human Smooth Muscle Cells within 3D Cocultures." Cleveland State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=csu1399977973.

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Cousseau, Thomas. "Etude du microenvironnement matriciel de biofilms de Bacillus subtilis : polymères extracellulaires et comportement bactérien." Thesis, Cergy-Pontoise, 2018. http://www.theses.fr/2018CERG0981.

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Bacillus subtilis est une bactérie à Gram positif ubiquitaire vivant dans différents environnements terrestres et aquatiques. Différents polymères extracellulaires entrant dans la composition de la matrice des biofilms à B. subtilis ont été décrits. Des polysaccharides sont à la base de ces propriétés mécaniques, la viscoélasticité étant modulée par la teneur du biofilm en différents polymères extracellulaires comme les protéines amyloïdes et l’ADN extracellulaire.L’objectif de ce travail était d’étudier le rôle des exopolymères dans les biofilms à B. subtilis en utilisant la souche type de l’

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Al-Maalouf, Samar Wadih. "Exploration of a mammary epithelial cell model for the study of epithelial inflammation and mechanisms of anti-inflammatory activity in medicinal plants." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1166806742.

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Crowley, Jessica Lynn. "Role of Supervillin, a Membrane Raft Protein, in Cytoskeletal Organization and Invadopodia Function." eScholarship@UMMS, 2009. https://escholarship.umassmed.edu/gsbs_diss/406.

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Crucial to a cell’s ability to migrate is the organization of its plasma membrane and associated proteins in a polarized manner to interact with and respond to its surrounding environment. Cells interact with the extracellular matrix (ECM) through specialized contact sites, including podosomes and invadopodia. Tumor cells use F-actin-rich invadopodia to degrade ECM and invade tissues; related structures, termed podosomes, are sites of dynamic ECM interaction and degradation. We show here that supervillin (SV), a peripheral membrane protein that binds F-actin and myosin II,reorganizes the actin

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Zague, Vivian. "Influência da suplementação com colágeno hidrolisado no metabolismo da matriz extracelular e proliferação de fibroblastos dérmicos humanos derivados de áreas fotoprotegida e fotoexposta, cultivados em monocamada e equivalente dérmico." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-08122015-202409/.

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Este trabalho investigou, pela primeira vez, a influência do CH na modulação do metabolismo e proliferação de fibroblastos dérmicos humanos (FDHs) derivados de áreas fotoprotegida e fotoexposta, cultivados em modelo de monocamada. Além disto, foram investigados os efeitos da suplementação com CH na secreção de colágeno tipo I, em modelo de cultura 3D de equivalente dérmico, derivado de matriz produzida exclusivamente por FDHs. O tratamento com CH não influenciou a proliferação celular dos fibroblastos derivados de ambas as áreas, porém modulou expressivamente o metabolismo dos FDHs cultivados

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LOCATELLI, LUIGI. "Expression of aVB6 integrin by Pkhd1-defective cholangiocytes links enhanced ductal secretion of Macrophage chemokines to progressive portal fibrosis in Congenital Hepatic Fibrosis." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2013. http://hdl.handle.net/10281/41733.

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BACKGROUND AND AIMS: Congenital Hepatic Fibrosis (CHF) is caused by mutations in PKHD1, a gene encoding for fibrocystin, a protein of unknown function, expressed in cholangiocyte cilia and centromers. In CHF, biliary dysgenesis is accompanied by severe progressive portal fibrosis and portal hypertension. The mechanisms responsible for portal fibrosis in CHF are unclear. The αvβ6 integrin mediates local activation of TGFβ1 and is expressed by reactive cholangiocytes during cholestasis. To understand the mechanisms of fibrosis in CHF we studied the expression of αvβ6 integrin and its regulation

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Lee, Po-Feng 1976. "The Impact of Extracellular Matrix Stiffness on Angiogensis." Thesis, 2012. http://hdl.handle.net/1969.1/148244.

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Sprouting endothelial cells (ECs) use soluble and insoluble cues to guide migration and expand the existing vascular network to meet changing trophic needs of the tissue during angiogenesis. A noninvasive and non-destructive nonlinear optical microscopy (NLOM) technique was used to optically image endothelial sprouting morphogenesis in three dimensional (3D) collagen matrices with simultaneously captured signals from collagen fibers and endothelial cells using second harmonic generation (SHG) and two-photon excited fluorescence (TPF), respectively. Sprout advancement and lumen expansion compa

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Manganare, Marcos M. "Promoting Extracellular Matrix Crosslinking in Synthetic Hydrogels." 2015. https://scholarworks.umass.edu/masters_theses_2/285.

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The extracellular matrix (ECM) provides mechanical and biochemical support to tissues and cells. It is crucial for cell attachment, differentiation, and migration, as well as for ailment-associated processes such as angiogenesis, metastases and cancer development. An approach to study these phenomena is through emulation of the ECM by synthetic gels constructed of natural polymers, such as collagen and fibronectin, or simple but tunable materials such as poly(ethylene glycol) (PEG) crosslinked with short peptide sequences susceptible to digestion by metalloproteases and cell-binding domains. O

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Jiang, Chang. "Signaling Pathways Involved in Mechanical Stimulation and ECM Geometry in Bone Cells." Thesis, 2010. http://hdl.handle.net/1805/2221.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The proliferation and differentiation of osteoblasts are influenced by mechanical and geometrical growth environments. A specific aim of my thesis was the elucidation of signaling pathways involved in mechanical stimulation and geometric alterations of the extracellular matrix (ECM). A pair of questions addressed herein was (a) Does mechanical stimulation modulate translational regulation through the phosphorylation of eukaryotic initiation factor 2 (eIF2)? (b) Do geometric alterations affect the phosphorylation patterns of mitogen

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Výborný, Karel. "Vývoj ECM materiálů pro léčbu centrálního nervového systému." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-438093.

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Výborný, Karel. Vývoj materiálů na bázi extracelulární matrix pro léčbu centrálního nervového systému. [Development of extracellular-matrix scaffolds for CNS repair]. Praha, 2020. 105 stran, 3 přílohy. Dizertační práce (Ph.D.). Univerzita Karlova, 2. lékařská fakulta, Ústav experimentální medicíny, AV ČR v.v.i. Abstract Brain and spinal cord injury are a serious traumata and despite intensive research, there is still no effective treatment for patients. One of the studied approaches is to use various biomaterials to repair the damaged neural tissue. The aim of this thesis is to study the regen

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Fuetterer, Lydia. "Optimization and Biological Characterization of Decellularized Adipose Tissue Scaffolds for Soft Tissue Reconstruction." Thesis, 2014. http://hdl.handle.net/1974/8600.

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It would be a great advantage in reconstructive surgery to have an off-the-shelf biomaterial to promote regeneration and volume augmentation following soft tissue damage. With this long-term objective, human adipose tissue (fat) is an abundant and accessible source of extracellular matrix (ECM) for bioscaffold fabrication. The main goal of the current research project was to optimize the established 5-day detergent-free decellularization protocol developed by the Flynn group, by shortening it to a maximum of 3 days, while achieving comparable results in terms of cell and lipid extraction with

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Hsin-HsuanYu and 游信瑄. "Exploring the mechanism underlying folate-deficiency induced swim bladder malformation and potential of herbal extracts modulating extracellular matrix (ECM) integrity." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/w4dfex.

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碩士<br>國立成功大學<br>醫學檢驗生物技術學系<br>105<br>Folate is an essential nutrient for mammals during pregnancy. There are many disease, including anemia, neural tube defects and cancer correlating to the folate deficiency. Previously, we observed in the folate-deficient zebrafish larvae that increased activity of cathepsin L, a protease crucial for maintaining ECM integrity, has contributed the defective formation of swim bladder. In the current study, we attempt to confirm the role of inflammatory cells in the FD-induced loss of swim bladder and search from an herbal extracts library for the remedy with p

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Goswami, Sumit. "Studies on the Role of Vitronectin and Plasminogen-Activator Inhibitor-1 Complexes Beyond Inhibiting Proteases: Binding to the Extracellular Matrix, Cell Interactions and Pathogenesis." 2010. http://trace.tennessee.edu/utk_graddiss/800.

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Plasminogen activator inhibitor-1 (PAI-1), a member of the serine protease inhibitor (serpin) superfamily of proteins, circulates in blood in a complex with vitronectin (VN). These two proteins are also found localized together in the extracellular matrix in many different pathophysiological conditions. Both of these proteins are involved with a number of physiologically important processes. Though PAI-1 is a well-known inhibitor of serine proteases, more emphasis is now geared towards its protease independent functions. VN, on the other hand, is a binding protein that exists in the circulatio

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