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Artykuły w czasopismach na temat „Extracellular matrix (ECM) peptides”

Autor: Grafiati

Data publikacji: 30 listopada 2024

Data aktualizacji: 31 lipca 2025

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1

Hozumi, Kentaro, and Motoyoshi Nomizu. "Mixed Peptide-Conjugated Chitosan Matrices as Multi-Receptor Targeted Cell-Adhesive Scaffolds." International Journal of Molecular Sciences 19, no. 9 (2018): 2713. http://dx.doi.org/10.3390/ijms19092713.

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Biomaterials are important for cell and tissue engineering. Chitosan is widely used as a scaffold because it is easily modified using its amino groups, can easily form a matrix, is stable under physiological conditions, and is inactive for cell adhesion. Chitosan is an excellent platform for peptide ligands, especially cell adhesive peptides derived from extracellular matrix (ECM) proteins. ECM proteins, such as collagen, fibronectin, and laminin, are multifunctional and have diverse cell attachment sites. Various cell adhesive peptides have been identified from the ECM proteins, and these are

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Tran, Thi Xuan Thuy, Gyu-Min Sun, Hue Vy An Tran, et al. "Synthetic Extracellular Matrix of Polyvinyl Alcohol Nanofibers for Three-Dimensional Cell Culture." Journal of Functional Biomaterials 15, no. 9 (2024): 262. http://dx.doi.org/10.3390/jfb15090262.

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An ideal extracellular matrix (ECM) replacement scaffold in a three-dimensional cell (3D) culture should induce in vivo-like interactions between the ECM and cultured cells. Highly hydrophilic polyvinyl alcohol (PVA) nanofibers disintegrate upon contact with water, resulting in the loss of their fibrous morphology in cell cultures. This can be resolved by using chemical crosslinkers and post-crosslinking. A crosslinked, water-stable, porous, and optically transparent PVA nanofibrous membrane (NM) supports the 3D growth of various cell types. The binding of cells attached to the porous PVA NM i

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Monteiro-Lobato, Gabriela M., Pedro S. T. Russo, Flavia V. Winck, and Luiz H. Catalani. "Proteomic Analysis of Decellularized Extracellular Matrix: Achieving a Competent Biomaterial for Osteogenesis." BioMed Research International 2022 (October 11, 2022): 1–18. http://dx.doi.org/10.1155/2022/6884370.

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Decellularized ECMs have been used as biological scaffolds for tissue repair due to their tissue-specific biochemical and mechanical composition, poorly simulated by other materials. It is used as patches and powders, and it could be further processed via enzymatic digestion under acidic conditions using pepsin. However, part of the bioactivity is lost during the digestion process due to protein denaturation. Here, stepwise digestion was developed to prepare a competent biomaterial for osteogenesis from three different ECM sources. In addition, three different proteases were compared to evalua

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Dolmatov, Igor Yu, and Vladimir A. Nizhnichenko. "Extracellular Matrix of Echinoderms." Marine Drugs 21, no. 7 (2023): 417. http://dx.doi.org/10.3390/md21070417.

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This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization. It includes a wide range of structural ECM proteins, as well as various proteases and their inhibitors. Members of almost all major groups of collagens, various glycoproteins, and proteoglycans have been found in echinoderms. There are enzymes for the synthesis of structural proteins and their modification by polysaccharides. However, the ECM of echinoderms substantially differs from that of vertebrates by the lack o

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Fujita, Motomichi, Manabu Sasada, Takuya Iyoda, Satoshi Osada, Hiroaki Kodama, and Fumio Fukai. "Biofunctional Peptide FNIII14: Therapeutic Potential." Encyclopedia 1, no. 2 (2021): 350–59. http://dx.doi.org/10.3390/encyclopedia1020029.

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Biofunctional peptide FNIII14, which is derived from the 14th fibronectin (FN) type III-like (FN-III) repeat of FN molecule, is capable of inhibiting cell adhesion to the extracellular matrix (ECM). This functional site is usually buried within the molecular structure of FN, but can be exposed by conformational changes and proteolytic cleavage. Peptide FNIII14 can induce a conformational change in β1-integrin from the active to the inactive form, causing functional inactivation. Based on this anti-adhesive activity, peptide FNIII14 exhibits therapeutic potential for several diseases such as me

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Olivares-Navarrete, Rene, Sharon L. Hyzy, Argelia Almaguer-Flores, et al. "Amelogenin Peptide Extract Increases Differentiation and Angiogenic and Local Factor Production and Inhibits Apoptosis in Human Osteoblasts." ISRN Biomaterials 2013 (August 1, 2013): 1–11. http://dx.doi.org/10.5402/2013/347318.

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Enamel matrix derivative (EMD), a decellularized porcine extracellular matrix (ECM), is used clinically in periodontal tissue regeneration. Amelogenin, EMD’s principal component, spontaneously assembles into nanospheres in vivo, forming an ECM complex that releases proteolytically cleaved peptides. However, the role of amelogenin or amelogenin peptides in mediating osteoblast response to EMD is not clear. Human MG63 osteoblast-like cells or normal human osteoblasts were treated with recombinant human amelogenin or a 5 kDa tyrosine-rich amelogenin peptide (TRAP) isolated from EMD and the effect

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Merchant, Michael L., Michelle T. Barati, Dawn J. Caster, et al. "Proteomic Analysis Identifies Distinct Glomerular Extracellular Matrix in Collapsing Focal Segmental Glomerulosclerosis." Journal of the American Society of Nephrology 31, no. 8 (2020): 1883–904. http://dx.doi.org/10.1681/asn.2019070696.

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BackgroundThe mechanisms leading to extracellular matrix (ECM) replacement of areas of glomerular capillaries in histologic variants of FSGS are unknown. This study used proteomics to test the hypothesis that glomerular ECM composition in collapsing FSGS (cFSGS) differs from that of other variants.MethodsECM proteins in glomeruli from biopsy specimens of patients with FSGS not otherwise specified (FSGS-NOS) or cFSGS and from normal controls were distinguished and quantified using mass spectrometry, verified and localized using immunohistochemistry (IHC) and confocal microscopy, and assessed fo

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Barnes, Ashlynn M., Tessa B. Holmstoen, Andrew J. Bonham, and Teisha J. Rowland. "Differentiating Human Pluripotent Stem Cells to Cardiomyocytes Using Purified Extracellular Matrix Proteins." Bioengineering 9, no. 12 (2022): 720. http://dx.doi.org/10.3390/bioengineering9120720.

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Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be differentiated into cardiomyocytes (hESC-CMs and iPSC-CMs, respectively), which hold great promise for cardiac regenerative medicine and disease modeling efforts. However, the most widely employed differentiation protocols require undefined substrates that are derived from xenogeneic (animal) products, contaminating resultant hESC- and iPSC-CM cultures with xenogeneic proteins and limiting their clinical applicability. Additionally, typical hESC- and iPSC-CM protocols produce CMs that are significantly contami

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Hulahan, Taylor S., Laura Spruill, Elizabeth N. Wallace, et al. "Extracellular Microenvironment Alterations in Ductal Carcinoma In Situ and Invasive Breast Cancer Pathologies by Multiplexed Spatial Proteomics." International Journal of Molecular Sciences 25, no. 12 (2024): 6748. http://dx.doi.org/10.3390/ijms25126748.

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Ductal carcinoma in situ (DCIS) is a heterogeneous breast disease that remains challenging to treat due to its unpredictable progression to invasive breast cancer (IBC). Contemporary literature has become increasingly focused on extracellular matrix (ECM) alterations with breast cancer progression. However, the spatial regulation of the ECM proteome in DCIS has yet to be investigated in relation to IBC. We hypothesized that DCIS and IBC present distinct ECM proteomes that could discriminate between these pathologies. Tissue sections of pure DCIS, mixed DCIS-IBC, or pure IBC (n = 22) with detai

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Mazzocchi, Andrea, Kyung Min Yoo, Kylie G. Nairon, et al. "Exploiting maleimide-functionalized hyaluronan hydrogels to test cellular responses to physical and biochemical stimuli." Biomedical Materials 17, no. 2 (2022): 025001. http://dx.doi.org/10.1088/1748-605x/ac45eb.

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Abstract Current in vitro three-dimensional (3D) models of liver tissue have been limited by the inability to study the effects of specific extracellular matrix (ECM) components on cell phenotypes. This is in part due to limitations in the availability of chemical modifications appropriate for this purpose. For example, hyaluronic acid (HA), which is a natural ECM component within the liver, lacks key ECM motifs (e.g. arginine–glycine–aspartic acid (RGD) peptides) that support cell adhesion. However, the addition of maleimide (Mal) groups to HA could facilitate the conjugation of ECM biomimeti

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Marin, Davide, and Silvia Marchesan. "Self-Assembled Peptide Nanostructures for ECM Biomimicry." Nanomaterials 12, no. 13 (2022): 2147. http://dx.doi.org/10.3390/nano12132147.

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Proteins are functional building blocks of living organisms that exert a wide variety of functions, but their synthesis and industrial production can be cumbersome and expensive. By contrast, short peptides are very convenient to prepare at a low cost on a large scale, and their self-assembly into nanostructures and gels is a popular avenue for protein biomimicry. In this Review, we will analyze the last 5-year progress on the incorporation of bioactive motifs into self-assembling peptides to mimic functional proteins of the extracellular matrix (ECM) and guide cell fate inside hydrogel scaffo

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Iyoda, Takuya, та Fumio Fukai. "Modulation of Tumor Cell Survival, Proliferation, and Differentiation by the Peptide Derived from Tenascin-C: Implication ofβ1-Integrin Activation". International Journal of Cell Biology 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/647594.

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Cell adhesion to extracellular matrix (ECM) participates in various biological processes, such as cell survival, proliferation, differentiation, and migration. Since these processes are essential for keeping homeostasis, aberration of these processes leads to a variety of diseases including cancer. Previously, we found that a peptide derived from tenascin- (TN-) C, termed TNIIIA2, stimulates cell adhesion to ECM through activation ofβ1-integrin. It has been shown that TNIIIA2 can modulate cell proliferation and differentiation. Interestingly, TNIIIA2 could not only enhance cell proliferation b

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Glavey, Siobhan, Alexandra Naba, Salomon Manier, et al. "Proteomic Characterization of the Multiple Myeloma Bone Marrow Extracellular Matrix." Blood 124, no. 21 (2014): 2051. http://dx.doi.org/10.1182/blood.v124.21.2051.2051.

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Abstract Background The extracellular matrix (ECM) is a major component of the tumor microenvironment, contributing to the regulation of cell survival, proliferation, differentiation and metastasis. In multiple myeloma (MM), interactions between MM cells and the bone marrow (BM) microenvironment, of which the ECM forms a major component, are critical to the pathogenesis of the disease and the development of drug resistance. To date, despite some knowledge of the composition of the ECM in tumors, detailed profiling of the composition of the ECM in MM has not been carried out. Until recently ECM

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Graham, L. L., T. Friel, and R. L. Woodman. "Fibronectin enhances Campylobacter fetus interaction with extracellular matrix components and INT 407 cells." Canadian Journal of Microbiology 54, no. 1 (2008): 37–47. http://dx.doi.org/10.1139/w07-115.

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Campylobacter fetus is a recognized pathogen of cattle and sheep that can also infect humans. No adhesins specific for C. fetus have to date been identified; however, bacterial attachment is essential to establish an infecting population. Scanning electron microscopy revealed C. fetus attachment to the serosal surface of human colonic biopsy explants, a location consistent with the presence of the extracellular matrix (ECM). To determine whether the ECM mediated C. fetus adherence, 7 C. fetus strains were assessed in a solid-phase binding assay for their ability to bind to immobilized ECM comp

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Huet, C., C. Pisselet, B. Mandon-Pepin, P. Monget, and D. Monniaux. "Extracellular matrix regulates ovine granulosa cell survival, proliferation and steroidogenesis: relationships between cell shape and function." Journal of Endocrinology 169, no. 2 (2001): 347–60. http://dx.doi.org/10.1677/joe.0.1690347.

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The extracellular matrix (ECM), constituting the follicular basal lamina and present also between follicular cells and in the follicular fluid, is believed to regulate granulosa cell (GC) function during follicular development. Ovine GCs isolated from small (1-3 mm in diameter) or large (4-7 mm in diameter) antral follicles were cultured on various pure ECM components (type I collagen, fibronectin, laminin), synthetic substrata enhancing (RGD peptides) or impairing (poly 2-hydroxyethylmethacrylate (poly-hema)) cell adhesion, or in the presence of heparin. The effects of these factors, used alo

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Liu, Yuying, Jianping Gao, Lin Liu, et al. "Identification and Characterization of Fibronectin-Binding Peptides in Gelatin." Polymers 14, no. 18 (2022): 3757. http://dx.doi.org/10.3390/polym14183757.

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Collagen and fibronectin (FN) are important components in the extracellular matrix (ECM). Collagen-FN binding belongs to protein-protein interaction and plays a key role in regulating cell behaviors. In this study, FN-binding peptides were isolated from gelatin (degraded collagen) using affinity chromatography, and the amino acid sequences were determined using HPLC-MS. The results indicated that all FN-binding peptides contained GPAG or GPPG. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and dual-polarization interferometry (DPI) were used to anal

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Hulahan, Taylor S., Yeonhee Park, Laura Spruill, Hari Nakshatri, Marvella Ford, and Peggi M. Angel. "429 Spatial Investigation of the Extracellular Matrix Metastatic Niche in Invasive Breast Cancer by Mass Spectrometry Imaging." Journal of Clinical and Translational Science 8, s1 (2024): 128. http://dx.doi.org/10.1017/cts.2024.371.

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OBJECTIVES/GOALS: Metastasis to regional areas decreases invasive breast cancer (IBC) survival rate by 13%. Despite the clinical importance of lymph node involvement, the role of extracellular matrix (ECM) remodeling in metastases is unknown. We hypothesize that the spatial dysregulation of the collagen proteome facilitates pro-tumorigenic immune infiltration. METHODS/STUDY POPULATION: Lymph node metastases were compared to patient-matched primary tumor and normal lymph nodes using tissue microarrays (TMA) from 31 generational South Carolina women with IBC (black women, BW n=10, white women, W

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Biela, Sarah, Britta Striegl, Kerstin Frey, Joachim P. Spatz, and Ralf Kemkemer. "Distance-dependent adhesion of vascular cells on biofunctionalized nanostructures." Current Directions in Biomedical Engineering 3, no. 2 (2017): 683–86. http://dx.doi.org/10.1515/cdbme-2017-0144.

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AbstractCell-cell and cell-extracellular matrix (ECM) adhesion regulates fundamental cellular functions and is crucial for cell-material contact. Adhesion is influenced by many factors like affinity and specificity of the receptor-ligand interaction or overall ligand concentration and density. To investigate molecular details of cell-ECM and cadherins (cell-cell) interaction in vascular cells functional nanostructured surfaces were used Ligand-functionalized gold nanoparticles (AuNPs) with 6-8 nm diameter, are precisely immobilized on a surface and separated by non-adhesive regions so that ind

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Fujita, Motomichi, Manabu Sasada, Takuya Iyoda, and Fumio Fukai. "Involvement of Integrin-Activating Peptides Derived from Tenascin-C in Cancer Aggression and New Anticancer Strategy Using the Fibronectin-Derived Integrin-Inactivating Peptide." Molecules 25, no. 14 (2020): 3239. http://dx.doi.org/10.3390/molecules25143239.

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Matricellular proteins, which exist in association with the extracellular matrix (ECM) and ECM protein molecules, harbor functional sites within their molecular structures. These functional sites are released through proteolytic cleavage by inflammatory proteinases, such as matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), and the peptides containing these functional sites have unique biological activities that are often not detected in the parent molecules. We previously showed that tenascin-C (TNC) and plasma fibronectin (pFN), exam

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Wu, Chi-Chung, Sylvia Jeratsch, Johannes Graumann, and Didier Y. R. Stainier. "Modulation of Mammalian Cardiomyocyte Cytokinesis by the Extracellular Matrix." Circulation Research 127, no. 7 (2020): 896–907. http://dx.doi.org/10.1161/circresaha.119.316303.

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Rationale: After birth, cycling mammalian CMs (cardiomyocytes) progressively lose the ability to undergo cytokinesis and hence they become binucleated, which leads to cell cycle exit and loss of regenerative capacity. During late embryonic and early postnatal heart growth, CM development is accompanied by an expansion of the cardiac fibroblast (cFb) population and compositional changes in the ECM (extracellular matrix). Whether and how these changes influence cardiomyocyte cytokinesis is currently unknown. Objective: To elucidate the role of postnatal cFbs and the ECM in cardiomyocyte cytokine

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Suttinont, Chawapun, Yasumasa Mashimo, Masayasu Mie, and Eiry Kobatake. "Delivery of bFGF for Tissue Engineering by Tethering to the ECM." BioMed Research International 2015 (2015): 1–6. http://dx.doi.org/10.1155/2015/208089.

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Delivery of growth factors to target cells is an important subject in tissue engineering. Towards that end, we have developed a growth factor-tethered extracellular matrix (ECM). Here, basic fibroblast growth factor (bFGF) was tethered to extracellular matrix noncovalently. The designed ECM was comprised of 12 repeats of the APGVGV peptide motif derived from elastin as a stable structural unit and included the well-known cell adhesive RGD peptide as an active functional unit. To bind bFGF to the ECM, an acidic amino acid-rich sequence was introduced at the C-terminus of the ECM protein. It con

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Bat, V., C. Jones, F. Boudreau, N. Faucheux, and N. Perreault. "A150 DEVELOPMENT OF MIMETIC MATRICES AS INSTRUCTIVE ORGANOIDS MICROENVIRONMENT FOR THE STUDY OF COLONIC DISEASES." Journal of the Canadian Association of Gastroenterology 7, Supplement_1 (2024): 115–16. http://dx.doi.org/10.1093/jcag/gwad061.150.

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Abstract Background The functional complexity of the colonic epithelium is dependent on its interaction with the microenvironment involving gradients of soluble factors, extracellular matrix (ECM) proteins and stiffness. The influence of dynamic changes in the ECM has been observed in tumours, with variations in protein expression and rigidity. Their biomolecular impacts on epithelial cell behaviour are less studied due to the structural complexity of the matrix. Organoids offers a novel approach for the study of ECM biodynamics, as they require a matrix (Matrigel) to develop. Previous work sh

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Kittrell, Caroline G., Jade Macdonald, Blake Sells, et al. "Abstract 2581: Establishing a multi-omic spatial ECM proteome and N-glycome of pancreatic ductal adenocarcinoma tissues." Cancer Research 85, no. 8_Supplement_1 (2025): 2581. https://doi.org/10.1158/1538-7445.am2025-2581.

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Abstract Pancreatic Ductal Adenocarcinoma (PDAC), one of the leading causes of cancer related mortality nationwide, is characterized by an extensive desmoplastic stromal reaction and an altered N-glycome. Stromal collagens serve to modulate the immune microenvironment, limit nutrient and oxygen diffusion, influence chemotherapy resistance, and promote tumor progression and metastasis. Dysregulated cancer cell N-glycosylation also promotes immune evasion and neoplastic spread. Despite their important roles in cancer pathogenesis, little is known about the spatial localization and organization o

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Goke, M., A. Zuk, and D. K. Podolsky. "Regulation and function of extracellular matrix intestinal epithelial restitution in vitro." American Journal of Physiology-Gastrointestinal and Liver Physiology 271, no. 5 (1996): G729—G740. http://dx.doi.org/10.1152/ajpgi.1996.271.5.g729.

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Repair of epithelial injury in the gastrointestinal tract is initially accomplished by migration of epithelial cells from the wound edge (“restitution”). To assess expression and function of the extracellular matrix (ECM) in the restitution phase after epithelial injury, in vitro studies using wounded monolayers or a rat intestinal epithelium-derived cell line (IEC-6) were undertaken. IEC-6 cells expressed fibronectin (FN) mRNA and protein in large amounts and lesser quantities of laminin-beta 1 (LN beta 1) and LN gamma 1. Collagen IV (Col IV) was weakly expressed, and LN alpha 1 was not detec

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Jariwala, Nathan, Matiss Ozols, Alexander Eckersley, et al. "P13 Prediction and in vitro characterization of tetrapeptide matrikines with diverse effects on human dermal fibroblasts." British Journal of Dermatology 189, no. 1 (2023): e18-e19. http://dx.doi.org/10.1093/bjd/ljad174.034.

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Abstract The extracellular matrices (ECMs) of mammalian tissues play important roles in mediating and maintaining tissue function. However, aberrant and progressive remodelling of ECM components is a key feature in the pathology and ageing of many organs, including skin. Crucially, these degradative processes not only impair function, but may also release peptide fragments, known as matrikines, with cell signalling capabilities. In addition to endogenously produced matrikines, many exogenously applied bioactive peptides, with proven activity in skin, are homologous to naturally occurring amino

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Sottile, Jane, Feng Shi, Inna Rublyevska, Hou-Yu Chiang, Joseph Lust, and Jennifer Chandler. "Fibronectin-dependent collagen I deposition modulates the cell response to fibronectin." American Journal of Physiology-Cell Physiology 293, no. 6 (2007): C1934—C1946. http://dx.doi.org/10.1152/ajpcell.00130.2007.

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Communication between cells and the extracellular matrix (ECM) is critical for regulation of cell growth, survival, migration, and differentiation. Remodeling of the ECM can occur under normal physiological conditions, as a result of tissue injury, and in certain pathological conditions. ECM remodeling leads to alterations in ECM composition and organization that can alter many aspects of cell behavior, including cell migration. The cell migratory response varies depending on the type, amount, and organization of ECM molecules present, as well as the integrin and proteoglycan repertoire of the

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Pedrosa, Catarina R., Christel Chanseau, Christine Labrugère, Sivashankar Krishnamoorthy, and Marie-Christine Durrieu. "Mesenchymal Stem Cell Differentiation Driven by Osteoinductive Bioactive Nanoscale Topographies." Applied Sciences 11, no. 23 (2021): 11209. http://dx.doi.org/10.3390/app112311209.

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Human mesenchymal stem cells (hMSCs) respond to the characteristics of their surrounding microenvironment, i.e., their extracellular matrix (ECM). The possibility of mimicking the ECM offers the opportunity to elicit specific cell behaviors. The control of surface properties of a biomaterial at the scale level of the components of the ECM has the potential to effectively modulate cell response. Ordered nanoscale silicon pillar arrays were fabricated using reverse micelles of block copolymers on full wafers, with standard deviations lower than 15%. Bioactive synthetic peptides were covalently g

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Puah, Perng Yang. "ID2015 Preparation of graphene oxide/oligopeptides composite for promoting mesenchymal stem cell proliferation." Biomedical Research and Therapy 4, S (2017): 48. http://dx.doi.org/10.15419/bmrat.v4is.258.

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Human mesenchymal stem cells (hMSCs) treatments are being tested clinically for a range of disorders. However, ex vivo expansion of hMSCs is still depending on human or animal source extracellular matrix (ECM) molecules. These ECM molecules are expensive to manufacture, have limited scalability and high batch-to-batch variability. Surface modification techniques have been instrumental in the development of scaffolds that promote cell-surface interactions. In this study, the surface of graphene oxide (GO) was modified in order to promote the attachment and proliferation of mesenchymal stem cell

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Díaz, Alejandra Ferrer, and John Huang. "Abstract 136: Discerning the role of the extracellular matrix on epithelial-to-mesenchymal transition and invasiveness of glioblastoma multiforme using a xeno-free 3D hydrogel system." Cancer Research 85, no. 8_Supplement_1 (2025): 136. https://doi.org/10.1158/1538-7445.am2025-136.

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Abstract The invasive nature of cancer, driven by epithelial-to-mesenchymal transition (EMT), is a critical process influenced by external cues from the tumor microenvironment, such as extracellular matrix (ECM) composition. The ECM primes cells for EMT and metastasis, making it a key topic in understanding disease progression. For example, in glioblastoma multiforme (GBM), a grade IV astrocytoma and the most aggressive brain malignancy, EMT contributes to the highly invasive behavior of tumor cells, limiting patient survival to less than five years. Thus, developing in vitro models that can a

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de Cavanagh, Elena MV, Marcelo Ferder, Felipe Inserra, and Leon Ferder. "Angiotensin II, mitochondria, cytoskeletal, and extracellular matrix connections: an integrating viewpoint." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 3 (2009): H550—H558. http://dx.doi.org/10.1152/ajpheart.01176.2008.

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Malfunctioning mitochondria strongly participate in the pathogenesis of cardiovascular damage associated with hypertension and other disease conditions. Eukaryotic cells move, assume their shape, resist mechanical stress, accommodate their internal constituents, and transmit signals by relying on the constant remodeling of cytoskeleton filaments. Mitochondrial ATP is needed to support cytoskeletal dynamics. Conversely, mitochondria need to interact with cytoskeletal elements to achieve normal motility, morphology, localization, and function. Extracellular matrix (ECM) quantity and quality infl

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Kittrell, Caroline, Blake Sells, Lyndsay Young, Peggi Angel, and Richard Drake. "471 Defining proteomic and cellular elements of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment with mass spectrometry imaging." Journal of Clinical and Translational Science 9, s1 (2025): 139. https://doi.org/10.1017/cts.2024.1064.

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Objectives/Goals: Currently, a lack of screening markers and targeted therapies prevent clinicians from successfully treating PDAC. Precision medicine may allow oncologists to better combat this disease. To personalize care, knowledge of tumor protein posttranslational modifications, extracellular matrix makeup, and infiltrating immune cells is imperative. Methods/Study Population: Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) was employed to characterize the N glycosylation state, the ECM composition, and immune cell populations present within 10 formalin f

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Goldbloom-Helzner, Leora, Dake Hao, and Aijun Wang. "Developing Regenerative Treatments for Developmental Defects, Injuries, and Diseases Using Extracellular Matrix Collagen-Targeting Peptides." International Journal of Molecular Sciences 20, no. 17 (2019): 4072. http://dx.doi.org/10.3390/ijms20174072.

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Collagen is the most widespread extracellular matrix (ECM) protein in the body and is important in maintaining the functionality of organs and tissues. Studies have explored interventions using collagen-targeting tissue engineered techniques, using collagen hybridizing or collagen binding peptides, to target or treat dysregulated or injured collagen in developmental defects, injuries, and diseases. Researchers have used collagen-targeting peptides to deliver growth factors, drugs, and genetic materials, to develop bioactive surfaces, and to detect the distribution and status of collagen. All o

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Carvalho, Marta S., Joaquim M. S. Cabral, Cláudia L. da Silva, and Deepak Vashishth. "Bone Matrix Non-Collagenous Proteins in Tissue Engineering: Creating New Bone by Mimicking the Extracellular Matrix." Polymers 13, no. 7 (2021): 1095. http://dx.doi.org/10.3390/polym13071095.

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Engineering biomaterials that mimic the extracellular matrix (ECM) of bone is of significant importance since most of the outstanding properties of the bone are due to matrix constitution. Bone ECM is composed of a mineral part comprising hydroxyapatite and of an organic part of primarily collagen with the rest consisting on non-collagenous proteins. Collagen has already been described as critical for bone tissue regeneration; however, little is known about the potential effect of non-collagenous proteins on osteogenic differentiation, even though these proteins were identified some decades ag

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Peterson, Julie A., Susan A. Maroney, Nicholas D. Martinez та Alan E. Mast. "Major Reservoir for Heparin-Releasable TFPIα (Tissue Factor Pathway Inhibitor α) Is Extracellular Matrix". Arteriosclerosis, Thrombosis, and Vascular Biology 41, № 6 (2021): 1942–55. http://dx.doi.org/10.1161/atvbaha.120.315728.

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Objective: Human endothelial cells produce 2 alternatively spliced TFPI (tissue factor pathway inhibitor) isoforms that maintain anticoagulant properties of the vasculature. TFPIβ is glycosylphosphatidylinositol anchored on the cell surface. TFPIα has a basic C terminus sharing homology with VEGF (vascular endothelial growth factor) and is a heparin-releasable protein, suggesting it binds glycosaminoglycans on the endothelium surface. However, this is unclear because TFPIα is not on the surface of cultured endothelial cells. This study identifies the source of heparin-releasable TFPIα. Approac

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Lingasamy, Prakash, Kristina Põšnograjeva, Sergei Kopanchuk, et al. "PL1 Peptide Engages Acidic Surfaces on Tumor-Associated Fibronectin and Tenascin Isoforms to Trigger Cellular Uptake." Pharmaceutics 13, no. 12 (2021): 1998. http://dx.doi.org/10.3390/pharmaceutics13121998.

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Tumor extracellular matrix (ECM) is a high-capacity target for the precision delivery of affinity ligand-guided drugs and imaging agents. Recently, we developed a PL1 peptide (sequence: PPRRGLIKLKTS) for systemic targeting of malignant ECM. Here, we map the dynamics of PL1 binding to its receptors Fibronectin Extra Domain B (FN-EDB) and Tenascin C C-isoform (TNC-C) by computational modeling and cell-free binding studies on mutated receptor proteins, and study cellular binding and internalization of PL1 nanoparticles in cultured cells. Molecular dynamics simulation and docking analysis suggeste

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Lorentz, Axel, Detlef Schuppan, Andreas Gebert, Michael P. Manns, and Stephan C. Bischoff. "Regulatory effects of stem cell factor and interleukin-4 on adhesion of human mast cells to extracellular matrix proteins." Blood 99, no. 3 (2002): 966–72. http://dx.doi.org/10.1182/blood.v99.3.966.

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Abstract Mast cells are inflammatory and immunoregulatory cells resident in tissues. They develop from bone marrow-derived progenitor cells that enter the tissue through the blood circulation. The specific localization and migration of mast cells in tissues is dependent on their interaction with extracellular matrix (ECM) proteins. Adhesion of human mast cells isolated from intestinal mucosa and cultured in the presence of stem cell factor (SCF) to ECM proteins is analyzed. It was observed that SCF is a unique cytokine enhancing mast cell adhesion to all tested ECM proteins (fibronectin, lamin

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Gumpenberger, Matthias, Barbara Wessner, Alexandra Graf, et al. "Remodeling the Skeletal Muscle Extracellular Matrix in Older Age—Effects of Acute Exercise Stimuli on Gene Expression." International Journal of Molecular Sciences 21, no. 19 (2020): 7089. http://dx.doi.org/10.3390/ijms21197089.

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With advancing age, the skeletal muscle extracellular matrix (ECM) undergoes fibrotic changes that may lead to increased muscle stiffness, injury susceptibility and strength loss. This study tested the potential of different exercises to counter these changes by stimulating the activity of genes associated with ECM remodeling. Twenty-six healthy men (66.9 ± 3.9 years) were stratified to two of four groups, performing unilateral (i) conventional resistance exercise, (ii) conventional resistance exercise followed by self-myofascial release (CEBR), (iii) eccentric-only exercise (ECC) or (iv) plyo

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Ariel, Amiram, Eran J. Yavin, Rami Hershkoviz, et al. "IL-2 Induces T Cell Adherence to Extracellular Matrix: Inhibition of Adherence and Migration by IL-2 Peptides Generated by Leukocyte Elastase." Journal of Immunology 161, no. 5 (1998): 2465–72. http://dx.doi.org/10.4049/jimmunol.161.5.2465.

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Abstract Migration of inflammatory cells requires cell adhesion and their subsequent detachment from the extracellular matrix (ECM). Leukocyte activation and migration must be terminated to stop inflammation. Here, we report that IL-2 enhances human T cell adherence to laminin, collagen type IV, and fibronectin (FN). In contrast, neutrophil elastase, an enzyme activated during inflammation, degrades IL-2 to yield IL-2 fractions that inhibit IL-2-induced T cell adhesion to FN. The amino acid composition of two of these IL-2 fractions, which appear to block T cell adherence to FN, were analyzed,

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Papadimitriou, E., V. G. Manolopoulos, G. T. Hayman, et al. "Thrombin modulates vectorial secretion of extracellular matrix proteins in cultured endothelial cells." American Journal of Physiology-Cell Physiology 272, no. 4 (1997): C1112—C1122. http://dx.doi.org/10.1152/ajpcell.1997.272.4.c1112.

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We have identified a novel cellular action of thrombin on cultured rat adrenal medullary endothelial cells (RAMEC). Five-minute incubation of RAMEC with physiological concentrations of thrombin (<1 U/ml) caused within 3 h an increase in the basolateral deposition of the extracellular matrix (ECM) proteins fibronectin, laminin, and collagens IV and I, concomitant with a corresponding decrease in the apical release of these proteins into the medium. This shift in vectorial secretion of ECM proteins, quantitated with enzyme-linked immunoassays, was time dependent. Maximal stimulation of ECM pr

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Lin, Chien-Yu, Umar-Farouk Mamani, Yuhan Guo, Yanli Liu, and Kun Cheng. "Peptide-Based siRNA Nanocomplexes Targeting Hepatic Stellate Cells." Biomolecules 13, no. 3 (2023): 448. http://dx.doi.org/10.3390/biom13030448.

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Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) in the liver due to chronic injuries and inflammation. These injuries activate and transform quiescent hepatic stellate cells (HSCs) into proliferative myofibroblast-like cells, which are the key contributors to the secretin of ECM in the fibrotic liver. The insulin-like growth factor 2 receptor (IGF2R) is a multifunctional receptor that is overexpressed on activated HSCs and is a specific molecular marker of activated HSCs in the fibrotic liver. We recently discovered an IGF2R-specific peptide that significantly increa

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Sever, Melike, Gokhan Gunay, Mustafa O. Guler, and Ayse B. Tekinay. "Tenascin-C derived signaling induces neuronal differentiation in a three-dimensional peptide nanofiber gel." Biomaterials Science 6, no. 7 (2018): 1859–68. http://dx.doi.org/10.1039/c7bm00850c.

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Benoit, Yannick D., Jean-François Groulx, David Gagné, and Jean-François Beaulieu. "RGD-Dependent Epithelial Cell-Matrix Interactions in the Human Intestinal Crypt." Journal of Signal Transduction 2012 (September 5, 2012): 1–10. http://dx.doi.org/10.1155/2012/248759.

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Interactions between the extracellular matrix (ECM) and integrin receptors trigger structural and functional bonds between the cell microenvironment and the cytoskeleton. Such connections are essential for adhesion structure integrity and are key players in regulating transduction of specific intracellular signals, which in turn regulate the organization of the cell microenvironment and, consequently, cell function. The RGD peptide-dependent integrins represent a key subgroup of ECM receptors involved in the maintenance of epithelial homeostasis. Here we review recent findings on RGD-dependent

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Broekelmann, Thomas J., Nicholas K. Bodmer, and Robert P. Mecham. "Identification of the growth factor–binding sequence in the extracellular matrix protein MAGP-1." Journal of Biological Chemistry 295, no. 9 (2020): 2687–97. http://dx.doi.org/10.1074/jbc.ra119.010540.

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Microfibril-associated glycoprotein-1 (MAGP-1) is a component of vertebrate extracellular matrix (ECM) microfibrils that, together with the fibrillins, contributes to microfibril function. Many of the phenotypes associated with MAGP-1 gene inactivation are consistent with dysregulation of the transforming growth factor β (TGFβ)/bone morphogenetic protein (BMP) signaling system. We have previously shown that full-length MAGP-1 binds active TGFβ-1 and some BMPs. The work presented here further defines the growth factor–binding domain of MAGP-1. Using recombinant domains and synthetic peptides, a

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Hershkoviz, R., L. Preciado-Patt, O. Lider, et al. "Extracellular matrix-anchored serum amyloid A preferentially induces mast cell adhesion." American Journal of Physiology-Cell Physiology 273, no. 1 (1997): C179—C187. http://dx.doi.org/10.1152/ajpcell.1997.273.1.c179.

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Mast cells are known to accumulate in various inflammatory processes, some of which are known to be associated with increased local and systemic levels of acute-phase reactants such as serum amyloid A (SAA) or with amyloid deposition. The mechanism(s) by which mast cells are recruited to these sites, however, has not been fully elucidated. It has recently been shown that SAA interacts with extracellular matrix (ECM) components and thereby acts as a chemoattractant and regulator of immune cell migration. On the basis of these observations, we examined the effect of SAA on mast cell adhesion to

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Zhai, Yuanxin, Quanwei Wang, Zhanchi Zhu, et al. "Cell-derived extracellular matrix enhanced by collagen-binding domain-decorated exosomes to promote neural stem cells neurogenesis." Biomedical Materials 17, no. 1 (2021): 014104. http://dx.doi.org/10.1088/1748-605x/ac4089.

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Abstract Enhancing neurogenesis of neural stem cells (NSCs) is crucial in stem cell therapy for neurodegenerative diseases. Within the extracellular microenvironment, extracellular matrix (ECM) plays a pivotal role in modulating cell behaviors. However, a single ECM biomaterial is not sufficient to establish an ideal microenvironment. As multifunctional nanocarriers, exosomes display tremendous advantages for the treatments of various diseases. Herein, collagen binding domain peptide-modified exosomes (CBD-Exo) were obtained from the SH-SY5Y cell line infected with lentivirus particles encodin

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Mizejewski, Gerald J. "The Role of Ion Channels and Chemokines in Cancer Growth and Metastasis: A Proposed Mode of Action Using Peptides in Cancer Therapy." Cancers 16, no. 8 (2024): 1531. http://dx.doi.org/10.3390/cancers16081531.

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Metastasis (Met) largely contributes to the major cause of cancer deaths throughout the world, rather than the growth of the tumor mass itself. The present report brings together several of the pertinent contributors to cancer growth and metastatic processes from an activity standpoint. Such biological activities include the following: (1) cell adherence and detachment; (2) cell-to-cell contact; (3) contact inhibition; (4) the cell interfacing with the extracellular matrix (ECM); (5) tumor cell-to-stroma communication networks; (6) chemotaxis; and (7) cell membrane potential. Moreover, additio

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Osses, Nelson, and Enrique Brandan. "ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression." American Journal of Physiology-Cell Physiology 282, no. 2 (2002): C383—C394. http://dx.doi.org/10.1152/ajpcell.00322.2001.

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Transcription of specific skeletal muscle genes requires the expression of the muscle regulatory factor myogenin. To assess the role of the extracellular matrix (ECM) in skeletal muscle differentiation, the specific inhibitors of proteoglycan synthesis, sodium chlorate and β-d-xyloside, were used. Treatment of cultured skeletal muscle cells with each inhibitor substantially abolished the expression of creatine kinase and α-dystroglycan. This inhibition was totally reversed by the addition of exogenous ECM. Myoblast treatment with each inhibitor affected the deposition and assembly of the ECM c

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Wang, Brian X., Christopher Kane, Laura Nicastro, et al. "Integrins Increase Sarcoplasmic Reticulum Activity for Excitation—Contraction Coupling in Human Stem Cell-Derived Cardiomyocytes." International Journal of Molecular Sciences 23, no. 18 (2022): 10940. http://dx.doi.org/10.3390/ijms231810940.

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Engagement of the sarcoplasmic reticulum (SR) Ca2+ stores for excitation–contraction (EC)-coupling is a fundamental feature of cardiac muscle cells. Extracellular matrix (ECM) proteins that form the extracellular scaffolding supporting cardiac contractile activity are thought to play an integral role in the modulation of EC-coupling. At baseline, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) show poor utilisation of SR Ca2+ stores, leading to inefficient EC-coupling, like developing or human CMs in cardiac diseases such as heart failure. We hypothesised that integrin l

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Vitale, Mario, Tiziana Di Matola, Gianfranco Fenzi, Maddalena Illario, and Guido Rossi. "Fibronectin Is Required to Prevent Thyroid Cell Apoptosis through an Integrin-Mediated Adhesion Mechanism1." Journal of Clinical Endocrinology & Metabolism 83, no. 10 (1998): 3673–80. http://dx.doi.org/10.1210/jcem.83.10.5175.

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Apoptosis or programmed cell death occurs in a wide variety of cell types when adhesion to extracellular matrix (ECM) is denied. Invasion and metastasis by tumor cells involve the loss of normal cell-ECM contacts and require independence from such control mechanisms. We studied whether the immortalized thyroid cell line TAD-2 is a model suitable to investigate thyroid cell-ECM interaction, and we analyzed the role of integrin-fibronectin (FN) interaction in apoptosis. Adhesion, spreading, and cytoskeleton organization in TAD-2 cultured cells were dependent upon integrin-FN interaction. Cell sp

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Futaki, Yudai, Ikumi Amimoto, Megumi Tanaka, Tomoki Ito, and Yoshiaki Hirano. "Discovery of Cell Aggregate-Inducing Peptides." Processes 9, no. 3 (2021): 538. http://dx.doi.org/10.3390/pr9030538.

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Most cells within the human body interact with neighboring cells and extracellular matrix (ECM) components to establish a unique 3D organization. These cell–cell and cell–ECM interactions form a complex communication network of biochemical and mechanical signals critical for normal cell physiology. The behavior of cells in a 3D environment is fundamentally different from that of cells in monolayer culture. Aggregation can affect cell–cell interactions, being more representative of the normal tissue microenvironment. Therefore, 3D cell culture technologies have been developed. The general metho

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