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Artykuły w czasopismach na temat „Fast Disintegration Tablet (FDT)”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

RAHMAWATI, TIAS EKA. "Effect of Disintegrating Agents on Red Ginger (Zingiber officinale Roxb) Dry Extract Fast Disintegrating Tablets Using Direct Compression Method." Media Farmasi Indonesia 19, no. 2 (2024): 130–36. http://dx.doi.org/10.53359/mfi.v19i2.278.

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Red ginger (Zingiber officinale Roxb) is one of the medicinal plants that is effective as a medicine for nausea and vomiting. One of the techniques for developing traditional medicinal products is to make fast disintegrating tablets (FDT). This research aims to compare the effect of these various disintegrating materials on the physical properties of FDT. FDT red ginger extract is made using the direct compression method. The tablets obtained were physically evaluated including weight uniformity, hardness, friability, and disintegration time. The statistical results using the one-way ANOVA tes

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Fahmansyah, Lingga Pratama, Agus S, and Suparman. "REVIEW : OF SUPERDISINTEGRANT INGREDIENTS IN FAST DISINTEGRANT TABLET TABLET PREPARATIONS." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 3 (2024): 857–76. http://dx.doi.org/10.37874/ms.v9i3.1292.

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This study aimed to evaluate the potential of synthetic and natural disintegrating agents in fast-disintegrating tablet (FDT) formulations. The methodology used includes a comprehensive literature review on the definition, characteristics, working mechanisms, and applications of super disintegrants in the manufacture of FDTs. The results of the study showed that super disintegrants play an important role in facilitating rapid disintegration of tablets. Synthetic super disintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate have the advantage of lower concentratio

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Zulfikar, Muhaini, Arisanty Arisanty, and Sisilia Tresia Rosmala Dewi. "Formulasi Fast Disintegrating Tablet Ekstrak Rimpang Kunyit (Curcuma domestica) dan Perasan Umbi Kentang (Solanum tuberosum L)." Journal of Experimental and Clinical Pharmacy (JECP) 3, no. 2 (2023): 88. http://dx.doi.org/10.52365/jecp.v3i2.483.

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Fast Disintegrating Tablet (FDT) merupakan tablet yang dapat dipecah dalam waktu kurang dari 60 detik saat diletakkan di atas lidah dengan jumlah air yang minimal. Kunyit dan kentang digunakan untuk menurunkan kadar asam dalam lambung yang bertujuan untuk mengobati pasien penderita gastritis. Tujuan penelitian ini membuat formulasi FDT rimpang kunyit (Curcuma domestica) dan perasan umbi kentang (Solanum tuberosum L) dengan variasi konsentrasi sodium starch glycolate sebagai bahan penghancur yaitu formula I (2%), formula II (3%) dan formula III (4%). Penelitian dilakukan dengan metode observasi

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Shrestha, Sumit, and Sujata Bhandari. "Formulation Optimization and in-vitro Evaluation of Diclofenac Fast Disintegrating Tablets." MedS Alliance Journal of Medicine and Medical Sciences 3, no. 5 (2023): 30–34. http://dx.doi.org/10.3126/mjmms.v3i5.60041.

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INTRODUCTION: Fast disintegrating tablets (FDTs) are solid dosage forms that disintegrate and dissolve in the mouth without the need for water within a matter of seconds. In the present study, a fast-disintegrating tablet of diclofenac sodium was prepared using WOWTAB (without water) technology, and its in-vitro characters were analyzed to prepare an optimum formulation. MATERIALS AND METHODS: Diclofenac sodium and its reference standard along with other excipients were collected. Softer tablets with hardness ranging from 1.493 to 1.522 kg/cm2 were prepared using Plackett-Burman (PB) design an

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Rahane, RD, and Punit R. Rachh. "A REVIEW ON FAST DISSOLVING TABLET." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 50–55. http://dx.doi.org/10.22270/jddt.v8i5.1888.

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The convenience of administration and improved patient compliance are important in the design of oral drug delivery system which remains the preferred route of drug delivery inspite of various disadvantages. Fast disintegrating tablets (FDTs) have received ever-increasing demand during the last decade, and the field has become a rapidly growing area in the pharmaceutical industry. The popularity and usefulness of the formulation resulted in development of several FDT technologies. These techniques render the disintegration of tablet rapidly and dissolve in mouth in five seconds without chewing

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Chauhan, Kalindi, Rakesh Solanki, and Shivani Sharma. "A REVIEW ON FAST DISSOLVING TABLET." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 1. http://dx.doi.org/10.22159/ijap.2018v10i6.28134.

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In the present scientific scenario, the drug delivery technology has become extremely competitive and quickly evolving with ever-increasing demand. Fast dissolving tablet (FDT) is one such style of an innovative and distinctive drug delivery system. Once FDT is placed on the tongue, it disintegrates or dissolves quickly (in seconds) without chewing or water. Fast dissolving pills became well-liked because of higher patient compliance and most popular over typical capsules and tablets. Numerous FDT products entered the market in the nineteen eighties. This novel drug delivery like FDT or mouth

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Sendy Fitriani and Monica Kristiani. "PENGARUH VARIASI KONSENTRASI CROSCARMELLOSE SODIUM SEBAGAI SUPERDISINTEGRANT TERHADAP KARAKTERISTIK FISIK FAST DISSOLVING TABLET (FDT) GLIBENKLAMID." Journal Clinical Pharmacy and Pharmaceutical Science 1, no. 1 (2022): 26–32. http://dx.doi.org/10.61740/jcp2s.v1i1.4.

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Glibenclamide is a second generation DM drug sulfonylurea group with the properties of lowering blood sugar levels. Most glibenklamid preparations are available in conventional tablet form and can be developed into pharmaceutical preparations that are more practical and accelerate the therapeutic effect of Fast Dissolving Tablet (FDT). The physical characteristics of the FDT are faster wetting and disintegration times compared to conventional tablets. Superdisintegrant is an important component in FDT preparations because it affects the time of wettability and disintegration time of FDT. The p

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Rahmawati, Tias Eka, Agus Siswanto, and Asmiyenti Djaliasrin Djalil. "Optimization of Fast Disintegrating Tablets Diphenhydramine HCl using Co-process of Cross-link Yellow Kepok Banana Starch, Crospovidone, and Microcrystalline Cellulose." JURNAL ILMU KEFARMASIAN INDONESIA 21, no. 2 (2023): 231. http://dx.doi.org/10.35814/jifi.v21i2.1406.

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Diphenhydramine HCl is an antihistamine drug that is available in conventional tablet form. This study aimed to produce the optimum formula for a diphenhydramine fast disintegrating tablet (FDT) using a modification of starch, crospovidone, and microcrystalline cellulose (MCC) to produce quality tablets that meet the tablet's physical requirements and tablet dissolution. Starch modification was made using a two-step method of starch cross-link, then continued with silica coprecipitation. FDT was prepared by the direct compression method. Optimisation with the simplex lattice design (SLD) model

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Jayaramu, Rajamma Abburu, Sateesha Shivally Boregowda, Addanki Rahul Deva Varma, and Chandan Kalegowda. "Development of fast dispersing tablets of nebivolol: experimental and computational approaches to study formulation characteristics." Brazilian Journal of Pharmaceutical Sciences 50, no. 4 (2014): 956–63. http://dx.doi.org/10.1590/s1984-82502014000400031.

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Formulation of FDT (fast dispersing tablets) of nebivolol was optimized and evaluated using simplex lattice design (SLD). The influence of type and concentration of three disintegrants viz.,Ac-Di-Sol, Primojel and Polyplasdone XL on hardness, friability and disintegration time of tablet was studied. Response surface plot and the polynomial equations were used to evaluate influence of polymer on the tablet properties. Results were statistically analyzed using ANOVA, and a p < 0.05 was considered statistically significant. Results reveal that fibrous integrity and optimal degree of substituti

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Putranti, Widyasari, Desty Restia Rahmawati, Nining Sugihartini, and Teuku Nanda Saifullah. "Influence of croscarmellose in fast disintegrating tablet of Syzygium polyanthum extract." International Journal of Public Health Science (IJPHS) 13, no. 1 (2024): 438. http://dx.doi.org/10.11591/ijphs.v13i1.22666.

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Bay leaves (<em>Syzygium polyanthum</em>) contain the flavonoid quercetin which can be used as an antihyperlipidemic drug. The development of antihyperlipidemic drug formula in the form of fast disintegrating tablet (FDT) is needed for patients who experience dysphagia. FDT preparations require an optimal super disintegrant concentration to produce a good drug formula. This study aims to develop the FDT formula of bay leaves extract using the super disintegrant croscarmellose sodium (CCS) intra and extra-granular. FDT formulation using the wet granulation method with variations of

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Putranti, Widyasari, Desty Restia Rahmawati, Nining Sugihartini, and Teuku Nanda Saifullah. "Influence of croscarmellose in fast disintegrating tablet of Syzygium polyanthum extract." International Journal of Public Health Science (IJPHS) 13, no. 1 (2025): 438–46. https://doi.org/10.11591/ijphs.v13i1.22666.

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Bay leaves (Syzygium polyanthum) contain the flavonoid quercetin which can be used as an antihyperlipidemic drug. The development of antihyperlipidemic drug formula in the form of fast disintegrating tablet (FDT) is needed for patients who experience dysphagia. FDT preparations require an optimal super disintegrant concentration to produce a good drug formula. This study aims to develop the FDT formula of bay leaves extract using the super disintegrant croscarmellose sodium (CCS) intra and extra-granular. FDT formulation using the wet granulation method with variations of CCS concentrations; F

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12

Lestari, Agatha Budi Susiana, and Aldo Christian Jonathan. "Optimization of Crospovidone and Copovidone in Fast Disintegrating Tablet (FDT) Diphenhydramine HCl Using Factorial Design." Journal of Pharmaceutical Sciences and Community 20, no. 2 (2023): 121–29. http://dx.doi.org/10.24071/jpsc.006396.

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Diphenhydramine HCl is a drug used to treat motion sickness. Treatment of motion sickness needs rapid onset for successful therapy. Fast Disintegrating Tablet (FDT) is one dosage form that provides fast onset. The purpose of this study was to identify the dominant factors of crospovidone and copovidone, their interactions, and discover the optimum composition area to produce a FDT dosage form with optimum parameters involving hardness, friability, disintegration time, wetting time, and water absorption ratio. This study was experimental and used a factorial design. The result showed that copov

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Eva monica, Rollando Rollando, Rehmadanta Sitepu, Devi Rusvita Khoirul Nisah, Laurensia Nina Irawati, and Sinta Dwi Larasati Listio. "Formulation of Fast Disintegrating Tablet Paracetamol Employing Selected Super-disintegrant." International Journal of Research in Pharmaceutical Sciences 11, no. 3 (2020): 4323–33. http://dx.doi.org/10.26452/ijrps.v11i3.2648.

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The objective of this research was to investigate paracetamol FDT formula with potato starch and xanthan gum or glycine or ac di sol combination that can produce the best tablet quality. The tablets were prepared by direct compression technique. Superdisintegrant such as Glycine, Ac di sol, Xanthan Gum, and Potato Starch Extract was optimized as 1-19 % on the basis of least disintegration time. Binders such as HPMC were optimized along with optimized superdisintegrant concentration. 3,5% HPMC was selected as optimum binder concentration on the basis of least disintegration time. Granule parame

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S., Aher Smita, Saudagar R. B., and Shinde Mayuri S. "REVIEW: FAST DISSOLVING TABLET." International Journal of Current Pharmaceutical Research 10, no. 2 (2018): 5. http://dx.doi.org/10.22159/ijcpr.2018v10i2.25876.

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Fast dissolving tablets is one of the most widely accepted dosage forms and also most popular dosage form, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Some solid dosage forms like tablets and capsules are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various

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Ashutosh, Sharma, Bansal Mayank, and Sweta. "A Review on Fast Dissolving Tablet." International Journal of Current Pharmaceutical Review and Research 15, no. 04 (2023): 215–19. https://doi.org/10.5281/zenodo.12635965.

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AbstractThe convenience of administration and improved patient compliance are important in thedesign of oral drug delivery system which remains the preferred route of drug delivery inspiteof various disadvantages. Fast disintegrating tablets (FDTs) have received ever- increasingdemand during the last decade, and the field has become a rapidly growing area in thepharmaceutical industry. The popularity and usefulness of the formulation resulted indevelopment of several FDT technologies. These techniques render the disintegration oftablet rapidly and dissolve in mouth in five seconds without chew

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Aniket, G. Karodade, P. Wable Aniket, kharbal Gopal, S. Bhagat Sunil, and P. Deshmukh Swati. "Fast dissolving tablet." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 001–7. https://doi.org/10.5281/zenodo.11951879.

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Fast dissolving tablets have emerged as a popular dosage form, particularly beneficial for pediatric and geriatric patients facing challenges such as dysphagia or hand tremors. These tablets dissolve quickly in saliva without needing water, enhancing compliance and effectiveness of therapy. They offer advantages like easy portability, accurate dosing, and improved bioavailability. Various technologies, including spray drying and melt granulation, have been developed for their manufacturing. This review provides comprehensive information on fast dissolving tablets, covering their definition, ad

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Pituanan, Baginda Sati, and Silvia Surini. "FAST-DISINTEGRATING TABLET FORMULATION OF GINGER (ZINGIBER OFFICINALE ROSC.) EXTRACT USING COPROCESSED EXCIPIENT OF PRE-GELATINIZED CASSAVA STARCH-ACACIA GUM." International Journal of Applied Pharmaceutics 9 (October 30, 2017): 154. http://dx.doi.org/10.22159/ijap.2017.v9s1.77_84.

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Objective: Fast-disintegrating tablets (FDTs) are tablets that disintegrate and/or dissolve rapidly in the mouth, thereby helping patients who havedifficulty in swallowing tablets. Ginger extract contains gingerol and is generally known for its antiemetic property. This study aimed to obtain anduse coprocessed excipients of pre-gelatinized cassava starch (PCS) with acacia gum (AG) in FDT formulations of ginger extract.Materials and Methods: In this research, five types of PCS-AG coprocessed excipients (Co-PCS-AG) were prepared by mixed PCS and AG with thefollowing ratios mass of PCS and AG wer

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Edityaningrum, Citra Ariani, Tantri Sofia Fauziah, Zainab Zainab, and Hardi Astuti Witasari. "Optimizing Formula of Fast Disintegrating Tablet of Belimbing Wuluh Leaf Extract with Crospovidone and Croscarmellose Sodium as Superdisintegrant." Majalah Obat Tradisional 23, no. 1 (2018): 62. http://dx.doi.org/10.22146/mot.32002.

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Averrhoa bilimbi L. leaves can be used as an antidiabetic in the presence of flavonoid. Antidiabetic drugs were widely consumed by elderly patients who often had difficulty in consuming conventional tablets. Research in developing formulations of an antidiabetic drug that is capable of rapid disintegration and quickly dissolves when placed on the tounge is necessary, therefore it is formulated in fast disintegrating tablet dosage forms. The research aimed to formulate FDT of ethanol extract of Averrhoa bilimbi L. leaves with variation of superdisintegrant crospovidone and croscarmellose sodium

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Aniket G. Karodade, Aniket P. Wable, Gopal kharbal, Sunil S. Bhagat, and Swati P. Deshmukh. "Fast dissolving tablet." GSC Biological and Pharmaceutical Sciences 27, no. 1 (2024): 001–7. http://dx.doi.org/10.30574/gscbps.2024.27.1.0096.

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Fast dissolving tablets have emerged as a popular dosage form, particularly beneficial for pediatric and geriatric patients facing challenges such as dysphagia or hand tremors. These tablets dissolve quickly in saliva without needing water, enhancing compliance and effectiveness of therapy. They offer advantages like easy portability, accurate dosing, and improved bioavailability. Various technologies, including spray drying and melt granulation, have been developed for their manufacturing. This review provides comprehensive information on fast dissolving tablets, covering their definition, ad

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Lestari, Agatha Budi Susiana, Achmad Fudholi, Akhmad Kharis Nugroho, and Erna Prawita Setyowati. "Formula Optimization of Fast Disintegrating Tablet (FDT) of Centella asiatica (L.) Urb. Ethanolic Extract." JURNAL ILMU KEFARMASIAN INDONESIA 16, no. 1 (2018): 94. http://dx.doi.org/10.35814/jifi.v16i1.423.

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It has been proven that Centella asiatica (L.) Urb. herbs have an antioxidant activity that make it possible to used in preventing degenerative illness. Centella asiatica (L.) extract has been formulated to fast disintegrating tablet (FDT) dosage form. The aims of this study are to find the optimum formula of FDT of Centella asiatica (L.) Urb. The simplex lattice design method with 3 factors (which are mannitol as diluents, crospovidone as superdisintegrant and povidone as binder) and 2 levels of each was used. Centella asiatica (L.) Urb. extract was produce from maceration process using ethan

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Rustiani, Erni, Syalsabillah Halizah Wahyono, and Septia Andini. "Formulation and Evaluation of Fast Disintegrating Tablets Containing Broccoli Extract (Brassica oleracea) Using Crospovidone and Ac-Di Sol as Superdisintegrants." FITOFARMAKA: JURNAL ILMIAH FARMASI 14, no. 2 (2024): 132–39. https://doi.org/10.33751/jf.v14i2.23.

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Broccoli (Brassica oleracea) is known to contain flavonoid and glucosinolate compounds that act as acetylcholine enzyme inhibitors to improve memory in humans. To be practical and easy to use, broccoli is made in tablet dosage form. This study aims to determine the effect of the super disintegrants concentration of crospovidone and Ac-Di Sol on the physical quality of the Fast-Disintegrating Tablet (FDT) of broccoli extract. A total of 3 formulas were made using the wet granulation method and different concentrations of crospovidone and Ac-Di Sol, namely formula 1 (crospovidone 5% : Ac-Di-Sol

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Ahmed, Mohd Salman, Nikita Upadhyay, and P. K. Dubey. "A REVIEW ON FAST DISSOLVING TABLET." International Journal of Pharmaceutical Sciences and Medicine 7, no. 5 (2022): 37–47. http://dx.doi.org/10.47760/ijpsm.2022.v07i05.004.

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Fast dissolving tablets (FDTs) emerged as one of the popular and widely accepted dosage forms. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia) resulting many incidences of non-compliance and making the therapy ineffective. Specifically for paediatric patients because of incomplete development of the muscular and nervous system and case of geriatric patients suffering from Parkinson’s disorder. Oral dosage form and oral route are the most preferred administration route for various drugs with limitations like first-p

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Masih, Ashish, Amar Kumar, Shivam Singh, and Ajay Kumar Tiwari. "FAST DISSOLVING TABLETS: A REVIEW." International Journal of Current Pharmaceutical Research 9, no. 2 (2017): 8. http://dx.doi.org/10.22159/ijcpr.2017v9i2.17382.

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Fast dissolving tablets emerge as one of the popular and widely accepted dosage forms, especially for pediatric patients because of incomplete development of the muscular and nervous system and a case of geriatric patients suffering from Parkinson’s disorder or hand tremors. Few solid dosage forms like capsules and tablets are present days facing the problems like difficulty in swallowing (dysphagia), resulting in many incidences of non-compliance and making the therapy ineffective. Oral dosage form and oral route are the most preferred route of administration for various drugs have limitation

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Bhide, Prashant, and Reeshwa Nachinolkar. "FORMULATION DEVELOPMENT AND CHARACTERISATION OF MECLIZINE HYDROCHLORIDE FAST DISSOLVING TABLETS USING SOLID DISPERSION TECHNIQUE." International Journal of Applied Pharmaceutics 10, no. 4 (2018): 141. http://dx.doi.org/10.22159/ijap.2018v10i4.26493.

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Objective: The aim of the present investigation was to design and evaluate fast dissolving tablet (FDT) for the oral delivery containing solid dispersion of meclizine (MCZ) hydrochloride, an antiemetic drug.Methods: The solubility of meclizine was increased by preparing solid dispersions using mannitol as a carrier by fusion method. The prepared solid dispersion, was subjected for in vitro drug release, percent practical yield, drug content, infrared spectroscopy (IR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM). Optimized solid dispersion was incorporated to pr

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Dev, Druv, Diksha Kumari Rehal, and DN Prasad. "PREPARATION AND EVALUATION OF MODIFIED TAMARIND SEED GUM AS A NOVEL SUPERDISINTEGRANT." Journal of Drug Delivery and Therapeutics 8, no. 5-s (2018): 372–77. http://dx.doi.org/10.22270/jddt.v8i5-s.1994.

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The aim of present study was to preparation and evaluation of modified Tamarind seed as natural superdisintegrant. The extracted gum from the Tamarind seed was modified chemically by carboxymethylation of extracted gum was done to improve the hydrophilic nature of the gum. Futher, carboxymethylated gum was complexed by using calcium chloride to enhances the wetting capacity of the gum. The modification in functional group of extracted gum, carboxymethyled gum, Calcium complexed gum was studied by FT-IR spectrophotometer. The DSC studies shows that the changes in melting point of the carboxymet

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Salam, Sabeel, Reshma Fathima, P. P. Sreelekha, M. Kavya, and E. Anjali. "Statistical Optimization of Fast Dissolving Tablet Contains Isosorbide Dinitrate for the Treatment of Angina Pectoris." Biosciences Biotechnology Research Asia 20, no. 4 (2023): 1373–81. http://dx.doi.org/10.13005/bbra/3183.

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ABSTRACT: The ultimate objective about this experiment was to create a fast-dissolving tablet Isosorbide dinitrate that released its medication quickly. The physical properties of tablets, such as hardness, angle of repose, weight variation, and friability were assessed. In-vitro release was investigated, and a 22-factorial design was created. The results show that the in-vitro release shows that the F2 formulation has the highest release at 20 min. Tablet disintegration time ranges from 31 to 48 s. The hardness ranges from 6-7 kg/cm3. The friability test shows the range from 0.49-0.68%. The w

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Pawar, Harshala, Aishwarya Pawar, and Shraddha N. Bhavsar. "FAST DISINTEGRATING TABLETS - A NEW ERA IN NOVEL DRUG DELIVERY SYSTEM." International Journal of Advanced Research 10, no. 01 (2022): 94–109. http://dx.doi.org/10.21474/ijar01/14018.

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Among all dosage forms, fast-Disintegrating tablets are one of the most commonly used dosage forms, especially in children, because their nervous system and muscular system are not well developed compared to them in adults. and in adult patients with Parkinsons disease or hand tremors. Some fixed dosage forms, such as capsules and tablets, now have difficulty swallowing (dysphagia), which results in many cases of non-compliance and renders therapy ineffective. The most preferred routes of administration for various drugs are oral dosage forms and the oral route with specific limitations such a

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Prachi, Pawar* Akanksha Jadhav Gayatri Ghodke Vidya Anap Dr. Sanjay Ingale. "Review On Fast Dissolving Tablets." International Journal of Pharmaceutical Sciences 2, no. 10 (2024): 1748–60. https://doi.org/10.5281/zenodo.14011672.

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The fast dissolving tablet (FDT) is a new and unique drug delivery system that is rapidly focusing major  attention in the reasearch field of fast dissolving technology. In recent times, a few solid dosage forms, such as tablets and capsules, are dealing with issues such dysphagia, which causes difficulties  swallowing and leads to a high rate of non-compliance, ultimately causing the therapy  ineffective.Fast dissolving tablet are disintegrating or/and dissolve quickly without the need of water. These tablets are designed to dissolve or break down in saliva in the mouth, u

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Manish, Kumar Gupta*, Sharma Saurabh, Gupta Manish, and Sen Priya. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS." International Journal of Current Pharmaceutical Review and Research 13, no. 3 (2021): 13–19. https://doi.org/10.5281/zenodo.12667092.

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The convenience of administration and improved patient compliance are essential in thedesign of oral drug delivery system which remains the preferred route of drug deliveryinstead of various limitations. Fast disintegrating tablets (FDTs) have gained ever-increasingdemand during the last decade, and the field has become a rapidly growing area in thepharmaceutical industry. The popularity and usefulness of the formulation resulted indevelopment of several FDT technologies. These techniques give the disintegration of tabletrapidly and dissolve in mouth within one-minute seconds without chewing a

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Krishna, Pandey Manju, and Gupta Amresh. "Fast dissolving tablets: Opportunity in herbal drug delivery system." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 102–13. https://doi.org/10.5281/zenodo.13120020.

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The polyherbal preparation's pharmacological and phytochemical properties have been used all over the world. Single or multiple herbs (polyherbal) are utilized for treatment in Ayurveda. The Sarangdhar Samhita, a work of Ayurvedic literature, emphasized the idea of polyherbalism as a means of enhancing therapeutic efficacy. Individual plants' active phytochemical components are insufficient to produce the desired therapeutic effects. The medicinal effects and toxicity are improved when different herbs are combined in a specific ratio. Comforts of drug administration and patient compliance are

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Nandhini M, Voleti Vijaya Kumar, Suganya T, et al. "Formulation, development and evaluation of fast disintegrating tablet of dapsone by using natural super disintegrates." International Journal of Pharmaceutical Chemistry and Analysis 11, no. 3 (2024): 239–44. http://dx.doi.org/10.18231/j.ijpca.2024.034.

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The needof the fast-disintegrating tablets ever increasing day by day during the last decade. In this current research study, the effect of the natural super disintegrating agents in the Dapsone fast disintegrating tablets was compared. The natural super disintegrating agents were characterized for different physico chemical methods like Loss on drying, moisture content and Ash values.Dapsone was selected as a model drug, where the dapsone has low bioavailability due to this reason, dapsone solid dispersions were developed and the same was used to formulate the tablets. The formation of the so

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Gunda, Dr Raghavendra Kumar, JNS Kumar, ABS Prasad, et al. "DEVELOPMENT AND CHARACTERIZATION OF FAST DISSOLVING TABLETS FOR EMPAGLIFLOZIN." Journal of Applied Pharmaceutical Sciences and Research 7, no. 1 (2024): 27–31. http://dx.doi.org/10.31069/japsr.v7i1.05.

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Objective: The current study's objective is to develop and evaluate Fast dissolving tablets (FDT) for Empagliflozin. Empagliflozin, new class of oral hypoglycemic agent. It is indicated as an adjunct to exercise and diet to improve glycemic control in adult patients of type-2 diabetes. It acts by inhibiting sodium glucose co-transporter (SGLT-2). Since oral absorption of empagliflozin from tablet is comparatively poor, hence an effort was made to enhance its absorption by formulating it as the fast dissolving tablet. Methods: Using various quantities of Kollidon-CL & Ac-Di-Sol as Superdisi

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Shubham, Thoke* Dr. Avish Maru. "Formulations and Evaluation of Fast Disintegrating Tablets of Amlodipine Besylate: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4264–84. https://doi.org/10.5281/zenodo.15512978.

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Fast disintegrating tablets (FDTs) have revolutionized oral drug delivery by offering rapid disintegration and dissolution in the oral cavity without the need for water, thus enhancing patient compliance and convenience, especially in pediatric, geriatric, and dysphagic populations. Amlodipine Besylate, a widely used calcium channel blocker for hypertension and angina, often encounters challenges related to bitter taste, poor aqueous solubility, and delayed onset of action in conventional dosage forms. Formulating Amlodipine Besylate as an FDT can overcome these issues by enabling faster disin

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Farahiyah, Dewi, and Teuku Nanda Syaifullah Sulaiman. "Pengaruh kombinasi Superdisintegrant Crospovidone dan Croscarmellose Sodium pada sifat fisik dan disolusi Fast Disintegrating Tablet Hidroklorotiazid." Majalah Farmaseutik 17, no. 1 (2021): 140. http://dx.doi.org/10.22146/farmaseutik.v17i1.61756.

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Hidroklorotiazid (HCT) merupakan obat lini pertama untuk penanganan hipertensi. HCT memiliki kelemahan terkait bioavailabilitasnya yang rendah dan umumnya tersedia dalam bentuk sediaan tablet konvensional sehingga dapat menimbulkan masalah tersendiri bagi pasien yang tidak mampu menelan tablet. Fast disintegrating tablet (FDT) HCT merupakan tablet yang dapat terdisintegrasi dan terdisolusi dengan cepat di dalam mulut yang memungkinkan obat dapat diabsorpsi di daerah pregastric sehingga meningkatkan bioavailabilitas obat. Penelitian ini bertujuan untuk mendapatkan formula FDT HCT yang menghasil

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Dr., Dilip Agrawal, Ashok Kumar Sharma Mr., Rakesh Goyal Dr., Mukesh Bansal Dr., Mohit Khandelwal Mr., and Shaneza Aman Ms. "DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLET OF ETORICOXIB BY USING NATURAL SUPERDISINTEGRANT (FENUGREEK POWDER)." International Journal of Current Pharmaceutical Review and Research 12, no. 4 (2020): 01–08. https://doi.org/10.5281/zenodo.12667356.

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The demands for fast dissolving tablets have received ever increasing day by day during thelast two decade. In the proposed present project study, the effect of natural Superdisintegrantswas compared with synthetic Super disintegrants and conventional Super disintegrants in theof fast dissolving tablet formulation of Etoricoxib. Etoricoxib NSAID is used for thetreatment of mild to moderate pain in various conditions like (osteoarthritis) and reducingpain, swelling, and joint stiffness caused with rheumatoid arthritis. In the present work 9formulations of FDT (Fast dissolving tablet) of Etorico

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Novi, Novi, Agus Siswanto, and Wiranti Sri Rahayu. "Optimasi Formula Fast Disintegrating Tablet Domperidone Kombinasi Filler Binder Starch 1500, Manitol dan Avicel PH 102 dengan Simple Lattice Design." PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) 21, no. 1 (2024): 61. https://doi.org/10.30595/pharmacy.v21i1.22768.

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Domperidone adalah agonis anti-dopamin yang digunakan untuk mengontrol muntah. Salah satu pengembangan formulasi domperidone kerja cepat adalah dengan formulasi dalam bentuk fast disintegrating tablet. Penelitian ini bertujuan mendapatkan komposisi optimum Starch 1500, manitol dan Avicel PH 102 pada sediaan FDT (fast disintegrating tablet) domperidone. Metode simplex lattice design dengan software Design expert diterapkan dengan 3 variabel sehingga diperoleh 14 run formula. Tablet dibuat dengan metode cetak langsung. Tablet diuji mutu meliputi: sifat alir massa cetak, sifat fisik tablet, waktu

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Panraksa, Pattaraporn, Bin Zhang, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Sheng Qi, and Pensak Jantrawut. "‘Tablet-in-Syringe’: A Novel Dosing Mechanism for Dysphagic Patients Containing Fast-Disintegrating Tablets Fabricated Using Semisolid Extrusion 3D Printing." Pharmaceutics 14, no. 2 (2022): 443. http://dx.doi.org/10.3390/pharmaceutics14020443.

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With the ability to fabricate personalized dosage forms and considerably shorter manufacturing time, semisolid extrusion (SSE) 3D printing has rapidly grown in popularity in recent years as a novel, versatile manufacturing method that powers a wide range of applications in the pharmaceutical field. In this work, the feasibility of using SSE 3D printing to fabricate fast-disintegrating tablets (FDTs) that are pre-filled in dosing syringes was evaluated. The novel design approach, ‘tablet-in-syringe’, was aimed to ease the oral drug administration and improve the dosing accuracy for dysphagic pa

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Pratama, Adam Ferdian Sigit, Setia Budi, and Melviani Melviani. "Formulation and Evaluation of Chitosan as Disintegrant for Fast Disintegrating Tablet with Fennel Seed Extract (Foeniculum vulgare)." Jurnal Ilmu Farmasi dan Farmasi Klinik 20, no. 1 (2023): 28. http://dx.doi.org/10.31942/jiffk.v20i1.7272.

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Kitosan merupakan polimer yang berasal dari cangkang hewan laut yang berpotensi digunakan sebagai disintegran. Kitosan diformulasikan dengan ekstrak biji adas menjadi sediaan Fast Disintegrating Tablet (FDT) ini untuk meningkatkan efektifitas terapi pada pasien. Penelitian ini bertujuan untuk mengetahui pengaruh kitosan sebagai disintegran pada sifat fisik FDT Ekstrak Biji Adas. Metode penelitian menggunakan metode quasi experimental dengan rancangan one-group post-test only. Dibuat 4 formula FDT dengan variasi jumlah kitosan yaitu 6 (F1), 12 (F2), 18 (F3) dan 24 (F4). Tablet dievaluasi secara

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Siddhanshu, Jain, Khandelwal Mohit, Agrawal Dilip, and Goyal Rakesh. "DESIGN, DEVELOPMENT AND EVALUATION OF FAST DISSOLVING TABLET OF TIZANIDINE USING FENUGREEK SEED MUCILAGE." International Journal of Current Pharmaceutical Review and Research 14, no. 03 (2022): 108–12. https://doi.org/10.5281/zenodo.12658808.

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The demands for fast dissolving tablets have received ever increasing day by day during thelast decade. In the present projected study, the effect of natural superdisintegrant wascompared with synthetic super disintegrants and conventional super disintegrants in the offast dissolving tablet formulation of tizanidine Hcl. Tizanidine Hcl is a potent muscle relaxantwhich management of increased muscle tone associated with spasticity. In the present work12 formulations of FDT (Fast dissolving tablet) of tizanidine were prepared by using isolatedmucilage of fenugreek seed was evaluated and compiles

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Gupta, Sparsh, Rakesh Roshan Mali, and Vashali Goel. "Novel study in fast dissolving drug delivery system: a review." Indian Journal of Pharmaceutical and Biological Research 3, no. 01 (2015): 93–107. http://dx.doi.org/10.30750/ijpbr.3.1.14.

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Novel drug delivery systems are becoming increasingly sophisticated as pharmaceutical scientists acquire a better understanding of the physicochemical and bio-chemical parameters pertinent to their performance. Despite tremendous advancements in drug delivery, the oral route remains the perfect route for the administration. Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them.FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and ge

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A.B., Gangurde Mohammed Awais* V. A. Bairagi Abdurrahman Sanaurrehman Karishma Rajashri. "FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF FAST DISSOLVING TABLETS OF RAMIPRIL SOLID DISPERSION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 08 (2018): 8409–16. https://doi.org/10.5281/zenodo.1411687.

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<em>Ramipril is a prodrug belonging to the angiotensin</em>-<em>converting enzyme </em>(<em>ACE</em>) <em>inhibitor which is metabolized to Ramiprilat in the liver and, to a lesser extent, kidneys</em>.<em>The poor solubility and wett</em> <em>ability of Ramipril leads to poor dissolution and variations in bioavailability</em>.<em>Solid dispersion of Ramipril was prepared using Hydroxy propyl β</em>- <em>cyclodextrin to improve water solubility</em>. <em>Prepared solid dispersion was shown improved solubility in water of 97</em>.<em>5 µg</em>/<em>ml</em>. <em>Fast dissolving tablets

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Harshal, Gosavi* Dr. Avish Maru Jayshree Bhadane Nilesh Pawar. "Formulation And Evaluation Fast Disintegrating Tablet: A Comprehensive Review." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 2257–69. https://doi.org/10.5281/zenodo.15407833.

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The pharmaceutical industry's demand for fast disintegration tablets (FDTs) has grown over the last few years, and the field is growing quickly. Fast dissolving tablets (FDTs) are solid dosages that dissolve rapidly on the tongue and absorb the drug with the need for water in a few seconds. FDTs have been developed for bedridden, elderly, and paediatric patients as well as active individuals who are on the go and may not having access to water. Due to hand tremors and dysphasia, many older people will have trouble swallowing traditional oral dosage forms, including tablets, capsules, and solut

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Nishita, Soni, Agrawa Dilip, Kumar Sharma Ashok, Khandelwal Mohit, and Goyal Rakesh. "FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF HYOSCINE BUTYLBROMIDE." International Journal of Current Pharmaceutical Review and Research 14, no. 01 (2022): 56–64. https://doi.org/10.5281/zenodo.12666098.

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In present scenario, the drug delivery system has become highly competitive and rapidly mostevolving with ever increasing demand. Fast dissolving tablet (FDT) is such type of a noveland unique drug delivery system which is intensely gaining much attention in the researchfield of rapid dissolving technology.In the present projected study, the effect of natural Super disintegrants in the of fastdissolving tablet formulation of Hyoscine Butylbromide is carried out Butylscopolamine, alsoknown as HBB is a peripherally acting antimuscarinic, anticholinergic agent. It is used intreatment of pain and

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Pingale, Prashant L. "FORMULATION AND EVALUATION OF PRAVASTATIN FAST DISINTEGRATING TABLETS USING NATURAL SUPERDISINTEGRANT." Journal of Medical pharmaceutical and allied sciences 10, no. 3 (2021): 2977–81. http://dx.doi.org/10.22270/jmpas.v10i3.1450.

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The basic concept of FDT is the incorporation of superdisintegrants, which promotes breakdown of tablet quickly when kept or positioned on the tongue, allowing the drug to be released into the saliva. The rate of absorption is regulated by the solubility of the medication. The faster the dosage form of the medication dissolves in solution, the faster the therapeutic action is absorbed and initiated. In FDT, a medicine or dose form should dissolve or disintegrate in the saliva within 60 seconds. The objective of this research work is to formulate a Pravastatin tablet that disintegrated quickly

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Hutabarat, Rahmi, and Aileen Tanuwijaya. "FORMULASI DAN UJI HEDONIK SEDIAAN FAST DISINTEGRANTING TABLET (FDT) MINYAK ATSIRI Thymus vulgaris L. MENGGUNAKAN METODE KEMPA LANGSUNG." INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL 7, no. 2 (2022): 121–32. http://dx.doi.org/10.52447/inrpj.v7i2.4330.

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Salah satu obat dengan sediaan praktis adalah Fast Disintegrating Tablet. Thymus vulgaris mengandung minyak atsiri pada thyme tertinggi, diantaranya terdapat thymol sebesar 61.6%. Thymol terbukti dapat menghambat zona pertumbuhan bakteri Streptococcus pyogenes penyebab faringitis (diameter penghambatan dari 48,0 hingga 35,0 mm). Minyak atsiri tidak tahan proses pemanasan oleh sebab itu FDT Minyak Atsiri Timi dibuat dengan metode kempa langsung. FDT Minyak Atsiri Timi buat dalam 4 formula, yaitu Formula I, Formula II, Formula III, dan Formula IV dengan variasi zat aktif minyak atsiri Timi sebes

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Kaur, Manpreet, Amit Mittal, Monica Gulati, Deepika Sharma, and Rajesh Kumar. "Formulation and in vitro Evaluation of Fast Dissolving Tablets of Febuxostat Using Co-Processed Excipients." Recent Patents on Drug Delivery & Formulation 14, no. 1 (2020): 48–62. http://dx.doi.org/10.2174/1872211314666191224121044.

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Background: Febuxostat is a novel, orally-administered, powerful, non-purine, xanthine oxidase inhibitor used for treating gout and ceaseless tophaceous gout. The drug exhibits low bioavailability (about 49%) which is ascribed to its dissolution rate-limited absorption. Objective: The current work is aimed to provide a novel strategy to improve the dissolution profile and thus, the bioavailability of Febuxostat. Methods: Formulation of Fast Dissolving Tablets (FDT) is anticipated to provide immediate release of the drug, which in turn, will improve its dissolution profile to provide the initia

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Shah, Akashkumar, and Khushbu Patel. "Development and Evaluation of Therapeutically Beneficial Fast Dissolving Tablet Containing Herbal Extracts: A Quality by Design Approach." Indian Journal Of Science And Technology 18, no. 9 (2025): 682–95. https://doi.org/10.17485/ijst/v18i9.3480.

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Objectives: The QbD approach validates the formulation during development, ensuring therapeutic benefits through the careful selection of herbal extracts. Methods: Oral dosage forms, especially fast dissolving tablets with different herbal extracts (curcumin, saffron, and gingerol) were developed to get their desired therapeutic actions immediately. Quality by Design (QbD) emphasizes a science-based approach to product development. Design of Experiments (DOE) and ANOVA are used to analyze high-risk Critical Quality Attributes (CQAs). Design Expert software helps determine the optimal quantitie

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Islam, Nayyer, Muhammad Irfan, Nasir Abbas, et al. "Enhancement of solubility and dissolution rate of ebastine fast-disintegrating tablets by solid dispersion method." Tropical Journal of Pharmaceutical Research 19, no. 9 (2020): 1797–805. http://dx.doi.org/10.4314/tjpr.v19i9.1.

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Purpose: To investigate the efficiency of different solubilizing agents in improving solubility as well as dissolution rate of ebastine (a BCS class II drug) by incorporating prepared solid dispersion into fast disintegrating tablets.Method: The solubility of ebastine was determined in distilled water, lipids and solubilizing agents. Subsequently, the binary solid dispersions were prepared by kneading method using varying weight ratios of ebastine and solubilizing agents. The solid dispersions were then incorporated into fast disintegrating tablets (SD-FDT). Central composite rotatable design

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Adinarayanareddy, Pagadala, Dr J. N. Suresh Kumar, Routhu Nikhileshwar, Varri VenkataSatya Abhinaya, Doppalapudi Ramya, and Vemugadda Pavan Kumar. "Formulation and Evaluation of Fast Disintegrating Tablet of Solid Dispersion of Rifaximin- A Research." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 698–710. https://doi.org/10.35629/4494-1002698710.

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The aim of the present study was to formulate and evaluate fast disintegrating tablets of solid dispersions of Rifaximin. The solid dispersions of Rifaximin were prepared using PEG 6000 and PVP K30 in ratios of 1:1, 1:2, and 1:3 by the solvent evaporation method. These solid dispersions were then analyzed using Fourier Transform Infrared Spectroscopy(FTIR) there no drug an polymer interaction. The results showed that the solid dispersions had a better dissolution profile compared to the pure drug, with Formulation FD3 demonstrating the highest drug release of 96.6% in 40 minutes. Therefore, FD

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Rao, N. G. Raghavendra, Tarun Patel, and Rathan Kumar. "Development of Fast Dissolving Carbamazepine Tablets: Effect of Functionality of Superdisintegrants." International Journal of Pharmaceutical Sciences and Nanotechnology 3, no. 1 (2010): 824–33. http://dx.doi.org/10.37285/ijpsn.2010.3.1.5.

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Carbamazepine, a dibenzapine derivative with structure resembling that of tricyclic antidepressants, is used in the treatment of epilepsy. The major problem of this drug is very low solubility in biological fluids and poor bioavailability after oral administration. Carbamazepine fast dissolving tablets (FDT) have been prepared by direct compression method. Effects of superdisintegrants (such as croscarmellose sodium, crospovidone and sodium starch glycolate) on wetting time, disintegrating time, drug content, in vitro release, and stability parameters have been studied. The prepared tablets we

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