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Rozprawy doktorskie na temat „Fatty acid metabolism”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Taylor, George. "Fatty acid metabolism in cyanobacteria." Thesis, University of Exeter, 2012. http://hdl.handle.net/10871/9363.

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With crude oil demand rising and supplies being depleted, alternative energy, specifically biofuels, are of intense scientific interest. Current plant crop based biofuels suffer from several problems, most importantly the use of land needed for food. Cyanobacteria offer a solution to this problem as they do not compete with land for food and produce hydrocarbons that can be used as biofuels. Upon examination of metabolic pathways competing with hydrocarbon synthesis, it appeared that cyanobacteria lacked the major fatty acid degradative metabolic pathway β-oxidation, generally thought to be a

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2

Rose, Philip. "Indices of fatty acid metabolism." Thesis, Sheffield Hallam University, 1992. http://shura.shu.ac.uk/20296/.

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During the fed state energy requirements are met by glycolysis of carbohydrates. When the stores of carbohydrates are diminished, for example during prolonged fasting, metabolism switches to that of fatty acids. Fatty acids are broken down by fi-oxidation within the mitochondrial matrix. Prolonged fasting results in the production of ketone bodies. These can also be used as an energy source by the brain. In defects of fatty acid metabolism where individual steps are inhibited or blocked, such as medium chain acyl-CoA dehydrogenase deficiency, an abnormal accumulation of the metabolites that le

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3

Cryle, Max Julian. "Fatty acid metabolism by cytochromes P450 /." [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19452.pdf.

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4

Lippmeier, James Casey. "Fatty acid metabolism of marine microalgae." Thesis, University of Hull, 2007. http://hydra.hull.ac.uk/resources/hull:7014.

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Pathways for the biosynthesis of docosahexaenoic acid (DHA) and other polyunsaturated fatty acids (PUFA) were elucidated in two heterotrophic, marine microalgae; Schizochytrium sp. and Crypthecodinium cohnii. PUFA-requiring auxotrophs of both of these algae were created and used as tools for studying PUFA biosynthetic pathways. Additionally, equilibrium radio-labeling techniques were applied to algal cultures fed 14C-fatty acids. Both organisms were found to possess two distinct pathways for PUFA biosynthesis. One pathway, mediated by classical elongases and desaturases, was incomplete in both

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5

Brolinson, Annelie. "Regulation of Elovl and fatty acid metabolism." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university : Stockholm University Library [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8469.

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6

Baker, Genevieve Elizabeth. "Molecular insights into bacterial fatty acid metabolism." Thesis, University of Bristol, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.715811.

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7

Price, Claire Louise. "Candida CYP52 : alkane and fatty acid metabolism." Thesis, Swansea University, 2012. https://cronfa.swan.ac.uk/Record/cronfa42696.

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Cytochromes P450 are a superfamily of haem-thiolate proteins found in all kingdoms of life. To date 11294 enzymes have been identified and have been shown to be involved in the metabolism of a wide variety of substrates, including hydrocarbons and xenobiotics. In yeast and fungi the hydroxylation of alkanes is associated with a family of cytochromes P450 enzymes known as CYP52s. These enzymes are involved in the terminal hydroxylation of long-chain alkanes resulting in the production of alcohols, which can be further converted to form fatty acids and diacids. In vivo such hydrocarbons can be s

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8

Batugedara, Hashini Maneesha. "Fatty acid metabolism in Saccharomyces cerevisiae and effects of fatty acid metabolites on neutrophil function." Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1526893.

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<p> In the presence of arachidonic acid (AA), <i>Saccharomyces cerevisiae </i> produces prostaglandin E<sub>2</sub> (PGE<sub>2</sub>). <i> S. cerevisiae</i> and its metabolites may be consumed in products manufactured using the yeast (e.g. beer). Neutrophils are immune cells present in the gastrointestinal (GI) tract during inflammation. As a lipid-signaling molecule, PGE<sub>2</sub> can potentially modify neutrophil functions and exacerbate pre-existing inflammation. As neutrophil migration is a hallmark of inflammation, we investigated the impact of PGE<sub>2</sub> on neutrophil chemotaxis.

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9

Mardy, Jennifer Kai. "Fatty acid metabolism in isolated perfused mouse hearts." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ64969.pdf.

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10

Masterson, Christine. "Carnitine and fatty acid metabolism in higher plants." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254030.

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11

Emmision, Neil. "Aspects of fatty acid metabolism in cultured hepatocytes." Thesis, University of Newcastle Upon Tyne, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287298.

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12

Maher, Michael. "An epigenetic approach to fatty acid metabolism in haematological malignancies." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673704.

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The role of fatty acids to overcome stress and contribute to disease progression is becoming increasingly evident in haematological diseases. Further, epigenetic factors play an important role in the aetiology of myelodysplastic syndromes (MDS) and the transformation to secondary acute myeloid leukaemia (sAML). To investigate this in the MDS/sAML cell line, SKK-1, we employed a shRNA knockdown screen to target 912 epigenetic regulators. We then coupled this loss-of-function approach to a fatty acid metabolism-based assay with which we were able to cell-sort the SKK-1 cells based on the fatty a

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13

Bruce, Jennifer S. "Dietary saturated fatty acids and lipoprotein metabolism in the hamster." Thesis, University of Nottingham, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319647.

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14

Field, Helen Patricia. "The interrelationship of zinc and essential fatty acid metabolism." Thesis, University of Leeds, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236407.

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15

Madrigal, Jorge Fonseca. "Fatty acid metabolism in isolated enterocytes from salmonid fish." Thesis, University of Stirling, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440781.

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16

Kilaru, Aruna. "Fatty Acid Ethanolamide Metabolism Influences Growth and Stress Responses." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/4773.

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17

Brindle, N. P. J. "Comparative studies on the regulation of hepatic fatty acid metabolism." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374534.

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18

Neijat, Mohamed. "Omega-3 fatty acid enrichment of chicken eggs: Regulation of long chain polyunsaturated fatty acid metabolism in laying hens." Poultry Science, 2014. http://hdl.handle.net/1993/32076.

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Eggs enriched with omega-3 polyunsaturated fatty acids (PUFA), particularly the longer chain PUFA (LCPUFA, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) can boost human consumption of these fatty acids implicated in human health. Alpha-linolenic acid (ALA) from plant seeds/oils, primarily serve as the source of omega-3 PUFA for hens, however, the scarcity of ALA-rich plants and the limited conversion of ALA to LCPUFA are challenges for egg enrichment. Two major experiments were conducted to determine potential factors regulating egg enrichment of omega-3 LCPUFA based on detaile

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19

Farrell, Emma K. "Biosynthesis of fatty acid amides." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/1629.

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Primary fatty acid amides (PFAMs) and N-acylglycines (NAGs) are important signaling molecules in the mammalian nervous system, binding to many drug receptors and demonstrating control over sleep, locomotor activity, angiogenesis, vasodilatation, gap junction communication, and many other processes. Oleamide is the best-studied of the PFAMs, while the in vivo activity of the others is largely unstudied. Even less is known about the NAGs, as their discovery as novel compounds is much more recent due to low endogenous levels. Herein is described extraction and quantification techniques for PFAMs

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20

Takeuchi, Michiki. "Biochemical and applied studies on unsaturated fatty acid metabolisms in lactic acid bacteria." Kyoto University, 2015. http://hdl.handle.net/2433/199370.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19046号<br>農博第2124号<br>新制||農||1032(附属図書館)<br>学位論文||H27||N4928(農学部図書室)<br>31997<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授小川順, 教授加納健司, 教授植田充美<br>学位規則第4条第1項該当

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21

Portolesi, Roxanne, and roxanne portolesi@flinders edu au. "Fatty acid metabolism in HepG2 cells: Limitations in the accumulation of docosahexaenoic acid in cell membranes." Flinders University. Medicine, 2007. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20070802.103146.

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The current dietary recommendations for optimal health are designed to increase our intake of two bioactive omega-3 (n-3) fatty acids, eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), abundant naturally in fatty fish such as salmon. Health authorities recommend that the general population consume two to three fatty fish meals per week (1) for optimal health and for the prevention of cardiovascular disease. However, some modern Western societies consume only modest amounts of fish and seafood (2;3). Land based vegetable oils may provide an alternative to meet the

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22

Bhura-Bandali, Farah. "The cystic fibrosis transmembrane conductance regulator in essential fatty acid metabolism." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq22572.pdf.

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23

Corpeleijn, Eva. "Fatty acid metabolism, impaired glucose tolerance and the effects of lifestyle." [Maastricht] : Maastricht : [Maastricht University] ; University Library, Universiteit Maastricht [host], 2006. http://arno.unimaas.nl/show.cgi?fid=10536.

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24

Khan, Nusrat Sultana. "Studies on membrane fatty acid metabolism and transduction mechanisms in schizophrenia." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313663.

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25

Klizaite, Kristina [Verfasser]. "Medium-chain fatty acid metabolism in hepatocytes and adipocytes / Kristina Klizaite." Bonn : Universitäts- und Landesbibliothek Bonn, 2017. http://d-nb.info/115995514X/34.

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26

Taylor, Rebecca Clare. "Mycobacterial fatty acid metabolism : identification of novel drug targets and chemotherapeutics." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3192/.

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Tuberculosis has been a deadly human pathogen for thousands of years and is as prevalent and lethal now as it was in the pre-antimicrobials era. With new challenges continually being presented in the form of multidrug resistant strains evolving and the implications of the HIV epidemic, it is imperative that every effort is made to understand the causative agent, Mycobacterium tuberculosis, and develop new effective and affordable drugs to treat the disease. With this in mind, the first part of this project tests novel drugs that have been identified using different approaches. The desired targ

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27

Etwebi, Zienab. "Magnesium Regulation of Glucose and Fatty Acid Metabolism in HEPG2 Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307564164.

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28

Jones, Barney. "Ischaemia and efficiency in the isolated heart." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311982.

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29

Simoens, Christian. "Intravascular metabolism of lipid emulsions with different fatty acid pattern: influence on fatty acid profile of membrane phospholipids in target organs and cells." Doctoral thesis, Universite Libre de Bruxelles, 2011. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209776.

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30

Papamandjaris, Andrea A. "The effect of fatty acid chain length on energy metabolism in healthy women." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0026/NQ50233.pdf.

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31

Baker, Jennifer Mary. "The effect of extracellular pH on human platelet metabolism." Thesis, University of Birmingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368422.

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32

Chen, Chaw-Yuan. "Regulation, Evolution, and Properties of the ato Qperon and its Gene Products in Escherichia coli." Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc277592/.

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The regulation of short chain fatty acid metabolism has been examined. Metabolism of acetoacetate, and short chain fatty acids such as butyrate and valerate, is predicated upon the expression of genes of the ato operon. Acetoacetate induces expression of a CoA transferase (encoded by the atoDA genes) and expression of a thiolase (encoded by the atoB gene). Metabolism of saturated short chain fatty acids requires the activities of the transferase and thiolase and enzymes of 6-oxidation as well. Spontaneous mutant strains were isolated that were either constitutive or that were inducible by vale

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33

Teran-Garcia, Margarita de Lourdes. "Functional mapping and characterization of the responsive region required for polyunsaturated fatty acid regulation in the rat fatty acid synthase gene." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3035987.

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34

Furumoto, Hidehiro. "Studies on Nutraceutical Properties of Modified Fatty Acids by Autoxidation and Lactic Acid Bacterial Metabolism." Kyoto University, 2016. http://hdl.handle.net/2433/215592.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第19766号<br>農博第2162号<br>新制||農||1040(附属図書館)<br>学位論文||H28||N4982(農学部図書室)<br>32802<br>京都大学大学院農学研究科応用生物科学専攻<br>(主査)教授菅原達也, 教授澤山茂樹, 教授佐藤健司<br>学位規則第4条第1項該当

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35

Tunedal, Kajsa. "Mathematical modeling of fatty acid metabolism during consecutive meals and fasting : New insights into fatty acid regulation based on arterio-venous data." Thesis, Linköpings universitet, Institutionen för medicinsk teknik, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-177309.

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Obesity, type 2 diabetes, and cardiovascular diseases are major problems in today's society, causing millions of deaths every year. One of the main risk factors for these diseases is a dysregulation of the fatty acid metabolism, where the balance between release and uptake of fatty acids is disturbed. Thus, understanding how fatty acid metabolism works is of great importance in the battle against these diseases. The human fatty acid release and uptake can be unraveled by measuring the difference in metabolite concentrations between an artery before the adipose tissue and a vein draining the ti

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36

MAXWELL, BESS DEVERE. "SERUM FREE FATTY ACID CONCENTRATION DURING POST-EXERCISE RECOVERY (INSULIN, HUNGER)." Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/187956.

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In order to achieve a better understanding of the impact of exercise on the concentration of serum free fatty acids (FFA) during post-exercise recovery, the purposes of this study were: (1) to determine the relationships between exercise intensity, total exercise energy expenditure, and the concentration of serum FFA during post-exercise recovery; (2) to examine the effects of exoge- nous glucose on post-exercise serum FFA and hormones controlling the FFA response; and (3) to examine the impact of acute exercise on hunger. Untrained, 12-h fasted, college-age males performed cycle ergometer ex

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37

Stahl, Richard J. (Richard John). "Fatty acid and glycerolipid biosynthesis in pea root plastids." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22389.

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Fatty acid biosynthesis from (1-$ sp{14}$C) acetate was optimized in plastids isolated from primary root tips of 7-day-old germinating pea seeds. Fatty acid synthesis was maximum at 82.3 nmol/hr/mg protein in the presence of 200$ mu$M acetate, 0.5mM each of NADH, NADPH and CoA, 6mM each of ATP and MgCl$ sb2$, 1mM each of MnCl$ sb2$ and glycerol-3-phosphate (G3P), 15mM KHCO$ sb3$, and 0.1M Bis tris propane, pH 8.0 incubated at 35C. At the standard incubation temperature of 25C, fatty acid synthesis was linear for up to 6 hours with 80 to 120 $ mu$g/ml plastid protein. ATP and CoA were absolute

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38

Morgan, Eric E. "The Cardiac Fatty Acid Metabolic Pathway in Heart Failure." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1138394643.

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Waterman, Ian J. "Role of placental lipase in feto-placental fatty acid uptake and metabolism." Thesis, Robert Gordon University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298317.

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40

Guiu, Jurado Esther. "Deregulation of fatty acid metabolism in the adipose tissue of obese women." Doctoral thesis, Universitat Rovira i Virgili, 2016. http://hdl.handle.net/10803/386542.

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L'obesitat augmenta el risc i empitjora el pronòstic de moltes malalties. No obstant això, l'obesitat en sí no condueix necessàriament a aquestes comorbiditats. La disfunció del teixit adipós, l'acumulació de greix ectòpic i la desregulació del metabolisme dels àcids grassos (AG) en l’adipòcit semblen jugar un paper important en la determinació del risc d'un individu de desenvolupar comorbiditats. És per això que seria de gran interès estudiar els mecanismes relacionats amb la desregulació del metabolisme dels AG en el teixit adipós durant el desenvolupament de l'obesitat per tal de millorar e

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41

Mels, Catharina Martha Cornelia. "The assessment of detoxification metabolism in fatty acid oxidation deficiencies / C.M.C. Mels." Thesis, North-West University, 2010. http://hdl.handle.net/10394/4406.

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The concept of accumulating xenobiotics within the human body as a health risk is well known. However, these compounds can also be endogenous, as in the case of inborn errors of metabolism. Biotransformation of both exogenous and endogenous toxic compounds is an important function of the liver, and the critical balance between these systems is of fundamental importance for cellular health. Fatty acid ?-oxidation deficiencies are associated with characteristic clinical symptoms as a consequence of the accumulation of specific metabolites. For these accumulated metabolites various nutrients are

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42

Jackson, Kim Geraldine. "Acute and chronic effects of monounsaturated fatty acid intake on chylomicron metabolism." Thesis, University of Surrey, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360952.

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Intriago, Pablo. "Fatty acid metabolism in a flexibacterium and its role in crustacean nutrition." Thesis, Bangor University, 1990. https://research.bangor.ac.uk/portal/en/theses/fatty-acid-metabolism-in-a-flexibacterium-and-its-role-in-crustacean-nutrition(11232774-8084-428b-854b-8652696a0f43).html.

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The total fatty acid content of an estuarine Flexibacter trip and the relative proportion of the constituent fatty acids were affected by growth temperature, aeration and salinity. The proportion of Cl6:lw5 the main fatty acid, did not change with temperature, but was produced in higher concentrations in xhe aiMOu*t o{ shaking cultures. In contrast, the amount of both linoleic and linolenic acids varied with temperature and aeration. The concentration of Cl6:lw5 per mg of protein changed with temperature, whereas the concentrations of both polyunsaturates were relatively constant. Both the pro

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44

Zampelas, Antonios. "Effect of dietary fatty acid structure and composition on postprandial lipid metabolism." Thesis, University of Surrey, 1993. http://epubs.surrey.ac.uk/770401/.

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In this thesis effects of dietary fatty acid composition and of positional distribution of fatty acids in dietary TAG, on postprandial lipid and hormone responses, were investigated. A6 week fish oil supplementation period (2.7 g n-3 fatty acids per day) decreased fasting TAG and increased TC (p<0.05) and LDL-C (p<0.05) levels in normal subjects. Postprandial plasma TAG responses to a test meal were also significantly reduced following the fish oil supplementation period (area under the response curves, p<0.001). Apolipoproteins A-I and B responses did not alter in response to chronic fish oil

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45

Ford, Tyler John. "Engineering Escherichia Coli Fatty Acid Metabolism for the Production of Biofuel Precursors." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467357.

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Medium chain fatty acids (MCFAs, 6-12 carbons) are potential precursors to biofuels with properties similar to gasoline and diesel fuel but are not native products of Escherichia coli fatty acid synthesis. Herein we engineer E. coli to produce, metabolize, and activate MCFAs for their future reduction into alcohols and alkanes (potential biofuels). We develop an E. coli strain with an octanoate (8-carbon MCFA) producing enzyme (a thioesterase), metabolic knockouts, and the capability to inducibly degrade an essential metabolic enzyme that would otherwise divert carbon flux away from octanoate.

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McGilchrist, Peter. "Selection for muscling affects carbohydrate and fatty acid metabolism in beef cattle." Thesis, McGilchrist, Peter (2011) Selection for muscling affects carbohydrate and fatty acid metabolism in beef cattle. PhD thesis, Murdoch University, 2011. https://researchrepository.murdoch.edu.au/id/eprint/14808/.

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Genetic selection to enhance muscularity in beef cattle is desirable to increase retail beef yield and the profitability of the beef industry. However it is unknown how selection for greater muscling will impact on intermediary and muscle energy metabolism which may influence certain attributes of meat quality. In order to assess these impacts of selection for greater muscling in cattle, the physiological mechanisms that underpin the increase in retail beef yield must be identified. This thesis examined the impact of selection for greater muscling on: retail beef yield; muscle glycogen; whole

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47

CAPUTO, MANUEL. "DEPDC1A, a novel SREBP1 cofactor, regulates fatty acid metabolism in breast cancer." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2924764.

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Breast cancer (BC) figures as the most frequently diagnosed and the leading cause of cancer-related deaths among women worldwide. Despite considerable progress has been made in cancer detection and therapy assignment, several BCs become resistant to therapy and, moreover, a considerable proportion of patients develops metastasis during therapy or experiences relapse. Growing body of evidence indicates that alterations in tumour metabolism are linked to therapeutic resistance, tumour relapse and dissemination. These altered metabolic traits are caused by genetic alterations and environmental fa

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Brock, Trisha Jane. "Fatty acid metabolism in Caenorhabditis elegans characterization of the delta-9 fatty acid desaturases and identification of a key regulator, nhr-80 /." Online access for everyone, 2005. http://www.dissertations.wsu.edu/Dissertations/Fall2005/t%5Fbrock%5F121505.pdf.

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Montgomery, Colette. "Maternal docosahexaenoic acid (DHA) supplementation and fetal DHA accretion." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366298.

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MacFarlane, David Peter. "Factors determining the progression of nonalcoholic fatty liver disease : the role of abnormal fatty acid and glucocorticoid metabolism." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5914.

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Obesity and insulin resistance are associated with a constellation of features including hypertension, dyslipidaemia, type 2 diabetes, and premature cardiovascular disease, collectively termed the metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) represents the hepatic component of this syndrome, incorporating a spectrum of liver disease with increasing morbidity and mortality, from simple steatosis, to non-alcoholic steatohepatitis (or NASH), fibrosis, cirrhosis and ultimately hepatocellular carcinoma. However, factors influencing this progression are incompletely understood. In t

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