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Rozprawy doktorskie na temat „Fatty acids”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Baker, Nancy Carol. "The Associations Among Dietary Fatty Acids, Plasma Fatty Acids, and Clinical Markers in Postmenopausal Women with Diabetes." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1253666943.

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2

Syed, Rahmatullah M. S. K. "Synthesis and physical properties of C18 azido-oxygenated and N-heterocyclic fatty acid derivatives." Thesis, [Hong Kong : University of Hong Kong], 1991. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12964657.

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3

Huws, Enlli Haf. "Novel bio-active fatty acids." Thesis, Bangor University, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.568810.

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New methods were developed to produce thiolated analogues of Mycobacteria components. Thiolated tuberculostearic acid, (S)-18-mercapto-l O-methyloctadecanoic acid, was firstly produced in seven steps in an overall yield of 7.6 %. This was followed by the first synthesis of a thiolated simple mycolic acid, the disulfide, ((2R,2' R,3R,3' R)- 2,2' - (disulfanediylbis(tetradecane-14, I-diyl))bis(3-hydroxyhenicosanoic acid, in 11 steps in an overall yield of 2.6 %. The first synthesis of a thiolated u-rnethyl-zrcns-cyclopropane methoxy mycolic acid was also achieved using the newly developed method

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4

Pararasa, Chathyan. "Fatty acids, monocytes and ageing." Thesis, Aston University, 2013. http://publications.aston.ac.uk/20894/.

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Elevated free fatty acids (FFA) are a feature of ageing and a risk factor for metabolic disorders such as cardiovascular disease (CVD) and type-2 diabetes (T2D). Elevated FFA contribute to insulin resistance, production of inflammatory cytokines and expression of adhesion molecules on immune cells and endothelial cells, risk factors for CVD and T2D. Molecular mechanisms of FFA effects on monocyte function and how FFA phenotype is affected by healthy ageing remain poorly understood. This thesis evaluated the effects of the two major FFA in plasma, oleate and palmitate on monocyte viability, cel

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5

Kishino, Shigenobu. "Production of conjugated fatty acids by lactic acid bacteria." Kyoto University, 2005. http://hdl.handle.net/2433/86244.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第11617号<br>農博第1473号<br>新制||農||905(附属図書館)<br>学位論文||H17||N4010(農学部図書室)<br>UT51-2005-D366<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授清水昌, 教授加藤暢夫, 教授植田充美<br>学位規則第4条第1項該当

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6

Kew, Samantha. "Fatty acids and the immune system : dose response studies with n-3 polyunsaturated fatty acids." Thesis, University of Southampton, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396188.

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7

Yu, Rong. "Metabolic interactions among amino acids, phospholipids and fatty acids." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/45211.

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Cystic fibrosis (CF) is the most common life-shortening disorder among Caucasians. Excessive faecal bile acid loss, increased oxidant stress, reduced plasma choline, increased oxidant stress, reduced glutathione and alterations in essential fatty acids are well recognized in patients with CF. It is also well-known that diabetes perturbs the methionine-homocysteine cycle. However, experimental data linking loss of amino acids in CF or decreased glucose availability in experimental diabetes to altered phospholipids and fatty acid metabolism are lacking. In the liver, bile acids are conjugated wi

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8

Peet, Daniel J. "Protein-bound fatty acids in mammalian hair fibres /." Connect to thesis, 1994. http://eprints.unimelb.edu.au/archive/00000641.

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9

Sieberg, Maureen A. "Heritability and development of the free fatty acids and acylglycerideconstituent fatty acids in Vernonia galamensis oil." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280501.

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Since the mid-1970's, there has been active research on the development of Vernonia galamensis (Cass.) Less. as a potential new oilseed crop. Vernolic acid (cis-12:13-epoxy-cis-9-octadecenoic acid) comprises 70--75% of vernonia oil and is chemically reactive, affording it a variety of industrial applications. A concern in the domestication of an oilseed crop is to establish a breeding program to improve oil quality traits. The objectives of this research were to (1) develop a rapid procedure for seed analyses; (2) determine the development of vernonia oil; and (3) estimate the narrow-sense her

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10

Barton, Louise Marie. "Polyunsaturated fatty acids and adrenal steroidogenesis." Thesis, Royal Veterinary College (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.519549.

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11

Zhang, Runhou 1963. "Manipulating fatty acids in sheep milk." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102236.

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Four studies were conducted to investigate some factors affecting milk fatty acid composition of dairy ewes. The first study was performed to determine the influence of freezing temperatures and storage time on ovine milk composition and cheese making. The other three experiments were conducted to examine the effects of dietary added fats with different profiles of fatty acids from canola, sunflower and flaxseeds on animal performance, nutrient utilization, milk yield and cheese making. The main emphasis was on fatty acid composition, particularly CLA and Omega-3 fatty acids, in milk and chees

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12

Beysen, Carine. "Metabolic effects of specific fatty acids." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249513.

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13

Rogerson, Madeleine. "Interactions of phospholipids with fatty acids." Thesis, University of East Anglia, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398493.

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14

Glen, Anthony D. "Synthetic studies on cyclopropane fatty acids." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386040.

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15

Peacock, Lesley. "Isomeric fatty acids and platelet function." Thesis, University of Aberdeen, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253708.

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1. <i>Cis</i> unsaturated fatty acids were shown to inhibit porcine platelet aggregation in response to both collagen and thrombin. Fatty acids with a <i>trans</i> double bond had an anti-aggregatory effect on collagen-induced aggregation but this was significantly less than that observed with the <i>cis</i> equivalent and was diminished as the dose of agonist increased. Thrombin-induced platelet aggregation was unchanged or slightly potentiated by <i>trans</i> isomers. 2. Both the <i>cis</i> and <i>trans</i> isomeric acids inhibited collagen-induced TXB<sub>2</sub> production. The <i>trans</i

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16

Bonner, Shelagh Anne. "Immunomodulatory effects of dietary fatty acids." Thesis, University of Strathclyde, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366809.

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17

Wilson, Gillian Mary. "Fatty acids in human colonic mucosa." Thesis, University of Southampton, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316584.

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18

O'Keeffe, Majella. "New sources of polyunsaturated fatty acids." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/54727/.

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Two groups of essential fatty acids (n-6 and n-3) are needed in a healthy human diet. Current advice suggests an optimal ratio of about 4:1 for these polyunsaturated fatty acids (PUFAs) in the diet but in Western countries it is usually 10-20:1. The n-3 PUFAs are synthesized in photosynthetic organisms from where they move up the food chain. Fish in particular, are a rich source of twenty and twenty two carbon n-3 PUFAs which are particularly effective for humans. Fish oils have been shown to be beneficial in a variety of chronic inflammatory diseases. However, fish stocks arc under threat. Th

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19

Smith, Benjamin. "Mineral mediated catalysis of fatty acids." Thesis, Durham University, 2014. http://etheses.dur.ac.uk/10611/.

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In order to reduce reliance on fossil oil, and it’s associated problems, there is a need to develop new platform chemicals, fuels and products, in a sustainable way, from biomass. In this thesis the catalytic upgrading of fatty acids, derived from the lipid fraction of biomass, through deoxygenation reactions is studied. Chapter 1 reviews the general area of catalytic upgrading of biomass into biofuels and bioproducts. The history and motivation for alternative sources of fuels and materials are introduced, followed by a summary of the reaction processes currently utilised for biofuels and bio

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20

Thambugala, Dinushika. "Analysis of genetic diversity and expression of genes involved in fatty acid composition in flax (Linum usitatissimum L.) and comparative genomic analysis of their loci." Theoretical and Applied Genetics, 2013. http://hdl.handle.net/1993/30665.

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Flax (Linum usitatissimum L.) is one of the richest plant sources of omega-3 fatty acids praised for their health benefits. In this study, the extent of the genetic variability for genes encoding stearoyl-ACP desaturase (SAD), fatty acid desaturase 2 (FAD2) and 3 (FAD3) was determined by sequencing the six paralogous genes from 120 flax accessions representing a broad range of germplasm including some EMS mutant lines. A total of 6 alleles for sad1 and sad2, 21 for fad2a, 5 for fad2b, 15 for fad3a and 18 for fad3b were identified. Deduced amino acid sequences of the alleles predicted 4, 2, 3,

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21

Bradburn, David Michael. "Bile acids and short fatty acids in familial adenomatous polyposis." Thesis, University of Newcastle Upon Tyne, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308760.

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22

Qadir, Abdul. "The effects of endotoxaemia and omega-3 fatty acids on membrane fatty acids and cardiac G-proteins." Thesis, University of Aberdeen, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300911.

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Dietary manipulation was undertaken with the aim of influencing membrane composition and improving adrenergic dysfunction. The objective was to explore the effects of 5 days of continuous intra-duodenal feeding of diets containing n-3 PUFA on myocyte membrane phospholipids, contractility and G-protein. The control diet was omega-6 (n-6) PUFA from safflower oil. The animals were infused with either saline or endotoxin (1 mg/kg) in the last 24 hours. The diets resulted in incorporation of lipids with alteration in myocyte membrane lipid composition. The relative percentage of n-3 PUFA was increa

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23

Teran-Garcia, Margarita de Lourdes. "Functional mapping and characterization of the responsive region required for polyunsaturated fatty acid regulation in the rat fatty acid synthase gene." Access restricted to users with UT Austin EID Full text (PDF) from UMI/Dissertation Abstracts International, 2001. http://wwwlib.umi.com/cr/utexas/fullcit?p3035987.

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24

Bakare, Oladapo. "Synthesis and properties of sulphur-containing long chain fatty acid derivatives." Thesis, [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13544561.

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25

Torkko, J. (Juha). "Characterization of mitochondrial 2-enoyl thioester reductase involved in respiratory competence." Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514270312.

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Abstract Maintenance of the mitochondrial respiratory chain complexes plays crucial role for the aerobic metabolism of the eukaryotes such as unicellular yeasts, for example, Saccharomyces cerevisiae as well as of human being. Mitochondrial respiratory function has been studied using the yeast S. cerevisiae as a model organism. Since yeast cells are also able to grow without respiration by fermentation, identification of the nuclear genes linked to respiratory function is possible by generation of nuclear gene deletions and testing for respiration-deficient phenotype of the yeast deletion str

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26

Maisonet, Mildred, Ruby Yadav, and Edward Leinaar. "Role Of Perfluorooctanoic Acid On Serum Fatty Acids, Nhanes, 2003-2004." Digital Commons @ East Tennessee State University, 2015. https://dc.etsu.edu/etsu-works/2.

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Background: Fatty acids (FA) have a role on energy storage and membrane formation. FA consists of an aliphatic chain with varying number of carbon and a carboxylic functional group. Perfluorooctanoic acid (PFOA) exhibits a similar structure to that of the FA. Given their structural resemblance, we hypothesized that alterations in FA metabolism could arise from competition with PFOA for endogenous FA binding sites in transport and with FA binding proteins. Objectives: Explore associations of serum concentrations of perfluorooctanoic acid (PFOA) with serum concentrations of linoleic (LA), eicosa

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27

Scorletti, Eleonora. "Effect of omega-3 fatty acids in non-alcoholic fatty liver disease." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/422265/.

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The first chapter (Introduction) of the thesis summarises the pathogenesis of NAFLD and its associated risk factors such as type 2 diabetes and cardiovascular disease. Moreover, it describes: a) the potential beneficial effects of long chain omega-3 fatty acid treatment [docosahexaenoic acid (DHA) plus eicosapentaenoic acid (EPA)] in NAFLD; b) the effect of genotypes patatin-like phospholipase domain-containing protein-3 (PNPLA3 I148M) and the transmembrane 6 superfamily member 2 protein (TM6SF2 E167K), on the level of DHA and EPA enrichment and end of study liver fat percentage after DHA+EPA

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28

Akpinar, Arzu. "Transformations of fatty acids in filamentous fungi." Thesis, University of Hull, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363270.

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29

Pinto, Eva. "Polyunsaturated fatty acids and immune cell functions." Thesis, University of Greenwich, 2007. http://gala.gre.ac.uk/6268/.

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In MS patients there was a significantly positive relationship between membrane AA and TGF-ß1 indicating that it is the individual long chain (LC) PUFA, i.e. AA that regulate the levels of TGF-ß1. Investigation of the effects of n-6 and n-3 PUFAs on normal healthy PBMC production of TGF-ß1 in vitro showed that PBMC in the presence of phytohaemaglutinin (PHA) supplemented with LA, dihyomo-?-linolenic (DGLA) and arachidonic acid (AA) significantly increase TGF-ß1 compared with non-supplemented PHA-stimulated PBMCs. In contrast, TGF-ß1 levels from PHA-stimulated PBMCs supplemented with a-linoleni

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30

Abouzreba, Salem Ali. "Volatile fatty acids in the ambient atmosphere." Thesis, University of Bristol, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388115.

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31

Hartil, Kirsten. "Fatty acids, insulin sensitivity and skeletal muscle." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621348.

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32

Lalia, Antigoni. "Omega-3 fatty acids to combat sarcopenia." Thesis, College of Medicine - Mayo Clinic, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10124986.

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<p> <b>Background:</b> Age-related sarcopenia leads to frailty, physical disability and loss of independence. Although exercise is an effective strategy to counteract the prevailing loss of muscle mass, older adults exhibit blunted anabolic responses, and are often unable to adopt an active lifestyle due to comorbidities associated with aging. Long chain polyunsaturated fatty acids (n-3 PUFA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acid, are non-pharmaceutical nutrients which have surfaced for their potential anabolic properties on skeletal muscle and may be particularly beneficial i

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33

O'Shea, Karen Michelle. "Omega-3 Fatty Acids and Heart Failure." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1258128805.

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34

Wu, Zhiguo. "Ruminal synthesis and biohydrogenation of fatty acids /." The Ohio State University, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487683756125827.

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35

Afonso, Marise da Costa Pereira. "Enzymatic biodiesel production from free fatty acids." Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/3137.

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Mestrado em Materiais Derivados de Recursos Renováveis<br>O ácido oleico é um co-produto da refinação de óleos alimentares e é removido num passo antecedente à catalise alcalina na produção industrial de biodiesel. Este ácido gordo livre é uma fonte alternativa de biodiesel. Neste trabalho estudou-se a esterificação enzimática do acido oleico com metanol ou etanol. Definiu-se um planeamento experimental 22 para estudar a influência das variáveis razão molar álcool/ácido oleico(R) e concentração de enzima(E), as variáveis dependentes, na percentagem de conversão, a variável independente. As con

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36

Hudson, Elizabeth A. "Polyunsaturated fatty acids in tumour-induced cachexia." Thesis, Aston University, 1993. http://publications.aston.ac.uk/12600/.

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A transplantable murine colon adenocarcinoma (MAC16) was utilised as a model of human cancer cachexia. This tumour has been found to produce extensive weight loss, characterised by depletion of host body protein and lipid stores at a small tumour burden. This weight loss has been found to be associated with production by the tumour of a lipolytic factor, activity of which was inhibited in vitro by the polyunsaturated fatty acid (PUFA) eicosapentaenoic acid (EPA). EPA has also been shown to possess anti-tumour and anti-cachectic activity in vivo, leading to the hypothesis that fatty acids mobil

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37

Wang, Qianyi. "Fatty Acids, Cardiovascular Diseases, and Diabetes Mellitus." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:14117764.

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Cardiovascular disease (CVD) is the number one cause for mortality and morbidity around the world. Meanwhile, diabetes mellitus (DM) has become an emerging epidemic, causing 1.5 million deaths in 2012, with 80% occurring in low- and middle-income countries. Substantial evidence has linked both lifestyle and metabolic risk factors to increased risk of CVD and death, with suboptimal diet being the single leading modifiable cause of poor health (Lim. SS, et al, Lancet 2012). Of 20 top individual causes of disease burden worldwide, 8 are related to poor nutrition, including suboptimal intakes of v

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38

Di, Nunzio Mattia <1980&gt. "N-3 fatty acids and cardiovascular prevention." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2162/1/Di_Nunzio_Mattia_tesi.pdf.

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In this study we elucidate the role of polyunsaturated fatty acids (PUFAs) in the prevention of cardiovascular diseases, focusing the attention on their role in the modulation of acyl composition of cell lipids and of gene expression. Regarding this latter mechanism, the effectiveness of PUFAs as activators of two transcriptional factors, SREBPs and PPARs, have been considered. Two different model system have been used: primary cultures of neonatal rat cardiomyocytes and an human hepatoma cell line (HepG2). Cells have been supplemented with different PUFAs at physiological concentration, and

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Di, Nunzio Mattia <1980&gt. "N-3 fatty acids and cardiovascular prevention." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2009. http://amsdottorato.unibo.it/2162/.

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In this study we elucidate the role of polyunsaturated fatty acids (PUFAs) in the prevention of cardiovascular diseases, focusing the attention on their role in the modulation of acyl composition of cell lipids and of gene expression. Regarding this latter mechanism, the effectiveness of PUFAs as activators of two transcriptional factors, SREBPs and PPARs, have been considered. Two different model system have been used: primary cultures of neonatal rat cardiomyocytes and an human hepatoma cell line (HepG2). Cells have been supplemented with different PUFAs at physiological concentration, and

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40

MAININI, FRANCESCA. "ESTERIFICATION OF NATURAL COMPOUNDS WITH FATTY ACIDS." Doctoral thesis, Università degli Studi di Milano, 2012. http://hdl.handle.net/2434/170495.

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In this PhD project we dealt with β-sitosterol, resveratrol and quercetin, three natural substances featuring ascertained biological activities. These compounds are characterized by a limited bioavailability and a low stability: these features reduce their application in pharmaceutical, nutraceutical and dermocosmetic areas. In order to improve the above mentioned properties, we synthesized esters of these compounds, following either a chemical approach (resveratrol, quercetin, and β-sitosterol) and a enzymatic approach (resveratrol and β-sitosterol). The esterification was performed with satu

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41

Bell, John Gordon. "Influences of dietary polyunsaturated fatty acids on tissue fatty acid composition and eicosanoid production in Atlantic salmon (Salmo salar)." Thesis, University of Stirling, 1996. http://hdl.handle.net/1893/26665.

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1. The literature has been reviewed with respect to the dietary intake and subsequent metabolism of polyunsaturated fatty acids (PUFA), of both the n-6 and n-3 series, in teleost fish. Particular emphasis has been made to the physiological roles of PUFA with respect to cell membrane function and eicosanoid production. 2. Atlantic salmon post-smolts were fed practical-type diets, based on fish meal, in three separate dietary experiments of 10-16 weeks duration. The first trial compared dietary lipid supplied either as fish oil (FO) or as sunflower oil (SO) with the diets having an n-3/n-6 PUFA

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42

Hauff, Simone [Verfasser]. "Methyl-Branched Fatty Acids and Chiral Anteiso-Fatty Acids in Neutral and Polar Lipids of Biological Samples / Simone Hauff." Aachen : Shaker, 2010. http://d-nb.info/108188570X/34.

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MUREDDA, LAURA. "Modulation of gene expression of GPR fatty acids sensors/receptors by dietary fatty acids influences inflammatory response in adipocytes." Doctoral thesis, Università degli Studi di Cagliari, 2017. http://hdl.handle.net/11584/249593.

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The fate of dietary fatty acids is finely regulated by specific cellular receptors capable of sensing the quantity and the quality of fatty acids reaching different organs via lipoproteins or as free fatty acids (FFAs). These receptors named GPR fatty acids receptors/sensors seem to play a fundamental role in governing the fate of dietary fatty acids in adipocytes. Based on these features, in this work we evaluated the effect of free fatty acids on inflammatory markers and the involvement of GPR120 and GPR84 in modulating the inflammatory response in obesity as assessed in human adipocytes.

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44

Hawkes, Joanna Susan. "N-3 fatty acids, eicosanoids and control of inflammation /." Title page, contents and summary only, 1993. http://web4.library.adelaide.edu.au/theses/09PH/09phh392.pdf.

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Thesis (Ph. D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, and Rheumatology Unit, Royal Adelaide Hospital, 1994.<br>Errata slip inserted. Includes bibliographical references (leaves 178-199).

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45

富洵 and Xun Fu. "Lipase selectivity in reactions involving natural and synthetic fatty acids and fatty alcohols." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B3124015X.

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Fu, Xun. "Lipase selectivity in reactions involving natural and synthetic fatty acids and fatty alcohols /." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22032435.

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47

Kling, Marcel Robert. "Synthesis of very long chain fatty acid methyl esters /." Title page, table of contents and abstract only, 1991. http://web4.library.adelaide.edu.au/theses/09PH/09phk65.pdf.

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48

Lewis, Amanda Gloria. "Treatment of Hypertriglyceridemia with Omega-3 Fatty Acids: A Systematic Review." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd458.pdf.

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Gardiner, Neil Stockenstrom. "Essential fatty acids and ascorbic acid- interactions and effects on melanoma growth." Thesis, Rhodes University, 1990. http://hdl.handle.net/10962/d1018230.

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The present study was carried out to determine the effects and possible mechanisms of action of the essential fatty acids (EFAs) (linoleic acid (LA), gamma-linolenic acid (GLA) and arachidonic acid (AA)) and ascorbic acid (Asc) on BL6 murine melanoma growth in cell culture and in mice. Interactions between the nutrients in influencing melanoma growth as well as possible mechanisms of the interactions were also examined in the above systems. Cell culture studies revealed that all three EFAs (0-SOμg/ml) and Asc (0-200μg/ml) significantly inhibited melanoma growth at the concentrations used. The

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Orchard, Tonya Sue. "Fatty Acids and Risk of Fracture in Postmenopausal Women." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1306513275.

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