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Artykuły w czasopismach na temat „Fegurð”

Autor: Grafiati

Data publikacji: 29 lipca 2024

Data aktualizacji: 30 lipca 2024

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1

Brakemeier, Eva-Lotta. "Nachruf auf Hubert Feger." Psychologische Rundschau 74, no. 4 (2023): 245–46. http://dx.doi.org/10.1026/0033-3042/a000652.

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Milyutin, Vasily, Zuzana Birčáková, Mária Fáberová, Radovan Bureš, Peter Kollár, and Ján Füzer. "Effect of Rare-Earth Doping on Dynamic Magnetic Properties of FeGa Alloy." Materials Science Forum 1081 (March 24, 2023): 149–54. http://dx.doi.org/10.4028/p-97z6qj.

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The magnetization process at elevated frequencies (up to 15 kHz) of ring-shaped binary Fe81Ga19 alloy was studied. Frequency and magnetic field dependences of coercive field and remanent induction were analyzed. Hysteresis loops and initial permeability were studied at low (200 Hz) and high (15 kHz) frequencies. The same measurements were made for FeGaRE alloys to establish the effect of rare-earth elements on dynamic magnetic properties.

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Koklic, Tilen, Rima Chattopadhyay, Rinku Majumder, and Barry R. Lentz. "Factor Xa dimerization competes with prothrombinase complex formation on platelet-like membrane surfaces." Biochemical Journal 467, no. 1 (2015): 37–46. http://dx.doi.org/10.1042/bj20141177.

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Exposure of phosphatidylserine (PS) molecules on activated platelet membrane surface is a crucial event in blood coagulation. Binding of PS to specific sites on factor Xa (fXa) and factor Va (fVa) promotes their assembly into a complex that enhances proteolysis of prothrombin by approximately 105. Recent studies demonstrate that both soluble PS and PS-containing model membranes promote formation of inactive fXa dimers at 5 mM Ca2+. In the present study, we show how competition between fXa dimerization and prothrombinase formation depends on Ca2+ and lipid membrane concentrations. We used homo-

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Ulshöfer, Kuno, and Kommission für Geschichtliche Landeskunde In Baden-Württemberg. "Rezension von: Kommission für Geschichtliche Landeskunde in Baden-Württemberg (Hrsg.), Schwäbische Chroniken der Stauferzeit." Württembergisch Franken 64 (March 4, 2024): 299. http://dx.doi.org/10.53458/wfr.v64i.10704.

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Schwäbische Chroniken der Stauferzeit. Hrsg. von der Kommission für geschichtliche Landeskunde in Baden-Württemberg. Sigmaringen: Thorbecke. 1. Historia Weiforum. Neu hrsg., übers, u. erl. von Erich König. 1978 (Nachdr. d. Ausg. 1938) 28, 154 S.. 2. Die Zwiefalter Chroniken Ortliebs und Bertholds. Neu hrsg., übers, u. erl. von Luitpold Wallach, Erich König und Karl Otto Müller. 1978 (Nachdr. d. Ausg. 1941) 16, 60, 385 S.. 3. Die Chronik des Klosters Petershausen. Neu hrsg. u. übers, von Otto Feger. 1978 (Nachdr. d. Ausg. 1956) 276 S.

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Fedorov, Yury A., Darya F. Kostenko, and Irina V. Dotsenko. "Behavior of Nickel's Migration Forms in Water Along the Continuum “The Mius River's Estuary - the Taganrog Bay of the Azov Sea”." UNIVERSITY NEWS. NORTH-CAUCASIAN REGION. NATURAL SCIENCES SERIES, no. 4-2 (216-2) (January 18, 2023): 77–89. http://dx.doi.org/10.18522/1026-2237-2022-4-2-77-89.

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The studys results of nickel (Ni) migration forms in water along the continuum “the Mius River estuary - the Taganrog Bay of the Azov Sea” are presented. Standard methods, specialized equipment and mathematical and statistical analysis were applied. It is revealed that experimental data on the content of the nickel dissolved form do not exceed global background concentrations. The nickel suspended migration form with dominant values in the Mius River zone (54-71 % of the gross content) prevailed along the continuum. A symbiotic behavior was established for all Ni migration forms with a genera

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Al-Aizari, Ahmed Ali, Yaser Hassan Dewir, Rashid Sultan Al-Obeed, et al. "Study of Shoot Tip Necrosis Problems of Fegra Fig (Ficus palmata Forssk.) In Vitro in Saudi Arabia." HortScience 59, no. 8 (2024): 1127–32. http://dx.doi.org/10.21273/hortsci17765-24.

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This work studied the micropropagation of fegra fig (F. palmata Forssk.) during which we experienced the incidence of shoot-tip necrosis (STN). STN was evident during the shoot elongation stage, which was regenerated on Murashige and Skoog (MS) medium supplemented with 2 mg/L 6-benzylaminopurine. To alleviate SNT, we conducted a series of experiments and supplemented the medium with calcium chloride (40, 80, and 120 mg/L), ascorbic acid (50, 100, and 150 mg/L), silver nitrate (1, 2, and 3 mg/L), and boric acid (9.3, 12.4, and 15.5 mg/L). Results showed that all the treatments controlled STN at

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7

Birčáková, Zuzana, Vasily Milyutin, Peter Kollár, et al. "Magnetic characteristics and core loss separation in magnetostrictive FeGa and FeGaRE (RE = Tb, Y) alloys." Intermetallics 151 (December 2022): 107744. http://dx.doi.org/10.1016/j.intermet.2022.107744.

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Zúñiga Ugalde, Felipe. "Essential of Soil Science: Soil Formation, Functions, Use and Classification (World Reference Base, WRB). 2018. Borntraeger Science Publishers, Stuttgart, Germany. 171 p. (101 figuras, 22 tablas)." Agro sur 47, no. 1 (2019): 3–4. http://dx.doi.org/10.4206/agrosur.2019.v47n1-02.

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Este libro, corresponde a una traducción en inglés del texto de "Bodenkunde in Stichworten” publicado por primera vez en 1969 por el Prof. Diedrich Schröder, en Kiel (Schlichting, 1970) quien lo actualizó hasta su fallecimiento en 1988. En 1992, el profesor Winfried E. H. Blum (BOKU, Viena) retoma esta meritoria tarea publicando la 5.a edición de este libro (Stahr, 1993; Feger, 2007) hasta su 7.a edición en 2012. La presente versión en inglés se divide en nueve capítulos. La introducción es breve, pero muy clara respecto a las funciones y la importancia del suelo. En los ...

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9

Berrier-Lucas, Celine, and Charlène Arnaud. "Éditorial. Les Communs : un éclairage réflexif." Revue de l’organisation responsable Vol. 19, no. 2 (2024): 3–9. http://dx.doi.org/10.3917/ror.192.0003.

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Cet essai se propose de contribuer à l’appel lancé par Philippe Eynaud, Clément Feger et Corinne Vercher-Chaptal (2024), dans leur article introductif de ce numéro spécial, de considérer les « angles morts » de la recherche contemporaine sur les communs. Nous mobilisons les approches critiques en management afin de mettre en lumière la face sombre des communs, les communs négatifs (Mies & Bennholdt-Thomsen, 2001 ; Monnin, 2021), qui dans le contexte actuel de crises socio-écologiques et d’injustices prolifèrent (Tsing, 2015b). Cette critique prometteuse – et à travers elle, cet essai – con

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10

Abdelrahim, Ahmed M., Muhammad G. Abd El-Moghny, and Mohamed S. El-Deab. "In situ generation of exfoliated graphene layers on recycled graphite rods for enhanced capacitive performance of Ni–Co binary hydroxide." RSC Advances 11, no. 42 (2021): 26258–72. http://dx.doi.org/10.1039/d1ra03954g.

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A functionalized exfoliated graphite rod (FEGR), with a high surface area, is produced for use as a promising substrate for supercapacitors, via controlled oxidative treatment of a recycled graphite rod of exhausted zinc–carbon batteries.

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11

Drewelow, Horst. "Giftedness — More Than IQ." Gifted Education International 13, no. 2 (1998): 136–39. http://dx.doi.org/10.1177/026142949801300206.

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There is no doubt about the assertion that high intellectual abilities of different kinds play a substantial role in conceptions of giftedness. At the same time most researchers in theory agree that giftedness is not identical with high intelligence. An analysis of literature though is reflecting a different picture (Bartenswerfer, 1990, Feger, 1990; Carter & Swanson, 1990; Heller & Menacher, 1992; Rogers, 1989): Wherever giftedness is discussed, nothing but intellectual giftedness is meant. In many publications we find IQ scores, with differing cut-off-levels of 125, 130, 140, 150 poi

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12

Maier, Anna, Janina Bittner, Jörg M. Fegert, and Ulrike Hoffmann. "Sensibilisierung für (sexualisierte) Gewalt in der Jugendarbeit." deutsche jugend, no. 12 (December 9, 2022): 530–39. http://dx.doi.org/10.3262/dj2212530.

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Mit sexualisierter Gewalt gegen Kinder und Jugendliche und der Frage, wie man Mitarbeiterinnen und Mitarbeiter in der Jugendarbeit dafür sensibilisieren kann, befassen sich Anna Maier, Janina Bittner, Jörg M. Fegert und Ulrike Hoffmann in diesem Beitrag. Sie weisen darauf hin, dass es bei solchen Delikten nach wie vor eine erhebliche Dunkelziffer gibt. Viele Fälle von sexualisierter Gewalt werden nicht erkannt; die Betroffenen schweigen jahrelang aus Gründen wie Scham oder sozialem Druck. Weil etwa die Hälfte der Ehrenamtlichen in Deutschland regelmäßig mit Kindern und Jugendlichen arbeitet, k

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13

Kazumori, H., A. Yamada, M. Mita, T. Nokuo, and M. Saito. "Field Emission SEM with a Newly Developed FEGUN and Conical Strongly Excited Objective Lens." Microscopy and Microanalysis 6, S2 (2000): 764–65. http://dx.doi.org/10.1017/s143192760003631x.

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A newly developed cold FE-GUN which enables to us to obtain large probe current and low emission noise, and conical strongly excited objective lens has been installed on the JSM-6700F Scanning Electron Microscope (SEM). In the range of accelerating voltages from 0.5 to 15kV, this instrument has got much better resolution as compared with in-lens type SEM (Ohyama et al 1986)(Fig. 1). We can obtain high-resolution secondary electron images with large samples (ex. 150mm ϕ×10mmH).Our old type objective lens (Kazumori et al 1994) has the limitation of working distance (WD), but the new lens enables

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14

Adityo, Rayno Dwi. "Studi Normatif Legalitas Peran Tokoh Masyarakat Dalam Undang-Undang No. 7 Tahun 2012 Tentang Penanganan Konflik Sosial." JURNAL MAHKAMAH 2, no. 1 (2017): 1. http://dx.doi.org/10.25217/jm.v2i1.102.

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Currently indonesia often torn asunder with different kinds of events which is quite disturbing national stability start of the disintegration by separatist group and other’s. It is something that can be easy occur given indonesia is a archipelago state, so in controlled requires strength tight from own society or the state of directly. With the diversity of social conflict tribal often law ineffective so that we consider that the need for the role of an instrument informal as community figures, traditional leaders and religion figures that more actively in acktivity has purpose for making sta

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15

Setyawan, Wahyu Beny Mukti, and Fery Dona. "E-INTEGRATIVE CONTROL SYSTEM AS A COMMUNITY ORGANIZATION SUPERVISION DESIGN TO REALIZE THE CONCEPT OF STATE." Jurnal Hukum 36, no. 2 (2020): 117. http://dx.doi.org/10.26532/jh.v36i2.11390.

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The government, as the party that has the mandate from the people tosa feguar ditsso vereignty, has revoked permits for the establish men to social organizations which are deemed contrary to the ideology of the State. The Ministryof Law and Human Rights as the party that grants the permit can immediately revokethelicense on the basis of the contractus actus principle contained in the Perppu No. 2 of 2017 concerning Amendmentsto Law No. 17 of 2013 concerning Community Organization. Even though they have taken repressive steps, the Ministry of Law and Human Rights has not taken any preventiveact

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16

Nashawi, Fatimah A., Hani Y. Abdullah, Nahlaa A. Khalifa, Ibrahim A. Alzahrani, and Ahmed A. Al-Ghamdi. "Effect of Different Saudi Honey Types Mixed with Natural Substances on Some Bacterial Strains." Journal of King Abdulaziz University - Medical Sciences 24, no. 1 (2017): 23–31. http://dx.doi.org/10.4197/med.24-1.3.

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To evaluate the antibacterial eff ects of three types of Saudi honey (Feghra, Sider and Natural honey) alone and mixed with ginger or lemon in comparison to Manuka honey as a potential natural antibacterial agent. Saudi honeys were evaluated against five types of bacterial strains; Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Haemophilus influenzae and Streptococcus pneumoniae. Chocolate agars were prepared first with different concentrations of each type of honey, and then with specific concentrations either of ginger or lemon added to honey. Bacterial species were in

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17

Feldshtein, Eugene E., Larisa N. Dyachkova, and Justyna Patalas-Maliszewska. "On Investigating the Microstructural, Mechanical, and Tribological Properties of Hybrid FeGr1/SiC/Gr Metal Matrix Composites." Materials 14, no. 1 (2021): 174. http://dx.doi.org/10.3390/ma14010174.

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In recent years, studies of different properties of hybrid metal matrix composites, as well as very detailed issues, have been published. In this article, ready-made iron, graphite, and silicon carbide powders were used to produce the base material and composites. An analysis of some microstructural and mechanical properties, as well as the tribological behavior of metal matrix composites (MMCs), based on FeGr1 sintered material with the single and hybrid addition of a silicon carbide and graphite was undertaken. During the study, the flexural and compressive strength of MMCs were analyzed and

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18

Baureithel, Ulrike. "Buchrezension Aufarbeitung des sexuellen Kindesmissbrauchs in Deutschland, hgg. v. Jörg M. Fegert, Trauma & Gewalt, Heft 02, Klett-Cotta 2011." Sexuologie. Zeitschrift für Sexualmedizin, Sexualtherapie und Sexualwissenschaft 18, no. 34 (2011): 213–15. http://dx.doi.org/10.61387/s.2011.34.24.

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19

Baloga, Martin. "Constitutiones Synodales Ecclesiae Strigoniensis." Notitiae Historiae Ecclesiasticae 12, no. 2 (2023): 43–53. http://dx.doi.org/10.54937/nhe.2023.12.2.43-53.

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In 1493, the Ostrihom Synod was held. It resulted in the document Constitutiones Synodales Ecclesiae Strigoniensis printed in 1494 in Vienna. However, this print was not available to historians for many centuries. In the middle of the 20th century, two specimens were identified. One defective copy of the print is located in Zagreb, and the other one, the only complete copy, is stored in SNK in Martin. The publisher is Theobald Feger and the printer is Johann Winterburger. The press contains several regulations concerning the area of church life. The printed text contains 37 canons of the synod

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20

Chattopadhyay, Rima, Tilen Koklic, and Barry Lentz. "Factor Xa Dimerization and Prothrombinase Complex Formation Are Competitive Process On a Membrane Surface." Blood 114, no. 22 (2009): 2123. http://dx.doi.org/10.1182/blood.v114.22.2123.2123.

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Abstract Abstract 2123 Poster Board II-100 Exposure of phosphatidylserine (PS) molecules on activated platelet membranes is a crucial event in blood coagulation. Binding of PS to a specific site on factors Xa and on Va promotes prothrombinase assembly and enhances proteolytic activity of factor Xa. PS binding produces significant structural changes in both proteins. Recent studies demonstrate formation of inactive Xa dimer by both soluble, short-chain PS and PS-containing membranes at high Ca+2 concentration (Chattopadhyay et al.,2009, Biophys. J, 974). Association of factor Xa with factor Va

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21

Berghahn, K. L. "Poetische Vernunft. Moral und Asthetik im Deutschen Idealismus. Von Hans Feger. Stuttgart: Metzler, 2007. 630 Seiten. 79,95." Monatshefte 101, no. 2 (2009): 275–79. http://dx.doi.org/10.1353/mon.0.0118.

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Królczyk, Grzegorz, Eugene Feldshtein, Larisa Dyachkova, Mariusz Michalski, Tomasz Baranowski, and Roman Chudy. "On the Microstructure, Strength, Fracture, and Tribological Properties of Iron-Based MMCs with Addition of Mixed Carbide Nanoparticulates." Materials 13, no. 13 (2020): 2892. http://dx.doi.org/10.3390/ma13132892.

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In this paper, the features of the strength, fractures, and tribological behavior of metal-matrix composites based on the FeGr1 material are discussed. To improve the material properties, a mixture of SiC, Al2O3 and C nanoparticulates have been added to an iron-based matrix. The simplex lattice design method and hardness, compression, and bending tests were used to determine the mechanical properties. Scanning electron microscopy was applied for fracture features analysis. Different fracture types, mainly trans-crystalline quasi-brittle and brittle fracture or inter-granular fracture and micro

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23

Tesoro, Giuliana. "Advances in polyimide science and technology, C. Feger and M. M. Khojasteh, Eds., M/S/Htoo technomic publishing, 1993." Journal of Polymer Science Part A: Polymer Chemistry 31, no. 13 (1993): 3501. http://dx.doi.org/10.1002/pola.1993.080311343.

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Al-Aizari, Ahmed Ali, Yaser Hassan Dewir, Abdel-Halim Ghazy, Abdullah Al-Doss, and Rashid Sultan Al-Obeed. "Micropropagation and Genetic Fidelity of Fegra Fig (Ficus palmata Forssk.) and Grafting Compatibility of the Regenerated Plants with Ficus carica." Plants 13, no. 9 (2024): 1278. http://dx.doi.org/10.3390/plants13091278.

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Ficus palmata is an important fig species that produces edible and nutritious fruit and possesses several therapeutic uses. This study reports an effective method for the micropropagation of F. palmata using nodal explants. In vitro shoots were cultured for 7 weeks onto MS medium fortified with different concentrations of cytokinins, light intensities, sucrose concentrations, and light/dark incubation treatments. Optimal axillary shoot proliferation (10.9 shoots per explant) was obtained on a medium containing 30 g/L sucrose and supplemented with 2 mg/L 6-benzylaminopurine (BAP) under 35 μmol/

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25

Pyts, T. "NAMES OF METAL-PROCESSING CRAFTSMEN IN GERMAN DIALECTS." Вісник Житомирського державного університету імені Івана Франка. Філологічні науки, no. 3(98) (December 23, 2022): 171–82. http://dx.doi.org/10.35433/philology.3(98).2022.171-182.

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The article studies the Silesian, Low Prussian, and East Pomeranian names of metal-processing craftsmen of the 14th–16th centuries. The article substantiates the topicality of studying the German dialects that disappeared due to the World War II, analyses specialized literature, characterizes the history of studying the German names of craftsmen in the former East-German dialects, determines the level of their coverage, formulates the objective and task of the publication and outlines the perspectives of further academic research. Besides, the article provides the insight into the word-formati

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26

Jones, Shauna Laurel, Edda R. H. Waage, and Karl Benediktsson. "Himnesk rödd en helvískur andi? Um friðun álftar á Íslandi og nýlega árekstra álfta og kornbænda." Ritið 19, no. 3 (2019): 9–43. http://dx.doi.org/10.33112/ritid.19.3.2.

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Þegar árekstrar koma upp í sambúð dýra og manna er nauðsynlegt að skoða vel þær forsendur sem að baki liggja. Í greininni er fjallað um þær deilur sem sprottið hafa upp á síðustu árum um alfriðun álftarinnar og tengjast aukinni kornrækt. Í upphafi er gerð stutt grein fyrir nýlegum nálgunum sem tengjast auknum áhuga á sambandi dýra og manna í hugvísindum. Í stað þess að skoða dýr sem óvirka þolendur eða jafnvel vélar, eins og algengt hefur verið um aldir, er nú lögð áhersla á gerendahæfni þeirra og gagnvirk tengsl við umhverfi sitt. Þau eru virkir þátttakendur í lífpólitík hvers tíma. Friðun te

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27

Loveland, P. "Waldböden: ein Bildatlas der wichtigsten Bodentypen aus Österreich, Deutschland und der Schweiz - edited by Leitgeb, E., Reiter, R., Englisch, M., Lüscher, P., Schad, P. & Feger, K.H." European Journal of Soil Science 64, no. 6 (2013): 823. http://dx.doi.org/10.1111/ejss.12085.

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Gauer, J. "Book Review: Ernst Leitgeb, Rainer Reiter, Michael Englisch, Peter Lüscher, Peter Schad, Karl-Heinz Feger: Waldböden. Ein Bildatlas der wichtigsten Bodentypen aus Österreich, Deutschland und der Schweiz." Journal of Plant Nutrition and Soil Science 176, no. 4 (2013): 640–41. http://dx.doi.org/10.1002/jpln.201390024.

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Ennis, D. M. "Making Choices without Reference to Chemistry or Brains. Review of New Developments in Psychological Choice Modeling, by Geert De Soete, Hebert Feger, and Karl C. Klauer (Eds.)." Journal of Mathematical Psychology 37, no. 1 (1993): 136–42. http://dx.doi.org/10.1006/jmps.1993.1008.

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Fimm-Todt, Franziska, Joachim Lauterwasser, Eva-Maria Egenter, et al. "Abstract 4072: Cytotoxic effects of LRRK2 inhibitors in combined treatment with chemotherapeutic agents on a large panel of cancer cell lines." Cancer Research 82, no. 12_Supplement (2022): 4072. http://dx.doi.org/10.1158/1538-7445.am2022-4072.

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Abstract Leucin-rich repeat kinase 2 (LRRK2) plays an important role in the onset of sporadic as well as familial Parkinson’s disease. Pathogenic gain-of-function mutations of LRRK2 are associated with aberrant LRRK2 hyperactivity which results in neurotoxicity and protein aggregation caused by dysfunctional autophagy and vesicle trafficking. Thus, the development of LRRK2 inhibitors represents a promising strategy for the treatment of Parkinson’s disease. Interestingly LRRK2 mutations have also been reported to increase the risk for the onset of different types of cancer (e.g. breast, thyroid

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Schaich, Katharina, Daniel Feger, Oliver Siedentopf, Sarah Ulrich, and Jan Erik Ehlert. "Abstract 357: Characterization of KRas pathway inhibitors in 2D and 3D screening formats." Cancer Research 82, no. 12_Supplement (2022): 357. http://dx.doi.org/10.1158/1538-7445.am2022-357.

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Abstract The KRas/Raf/MEK signalling axis has been identified to play a critical role in the formation of cancer, resulting in several investigational new drugs targeting this pathway. Identification of appropriate drugs is hampered, however, by the assumption that a three-dimensional setting may be required to observe significant inhibitory effects, possibly due to alternate gene expression and protein activity in such a “closer-to-physiology” setting. In order to explore that topic, in the current study we have made use of our 140 cell lines (CL)-2D proliferation panel (3 days incubation) an

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Cherdron, H. "Polyimide: „Polyimides: Materials, Chemistry and Characterization”︁. Hrsg. von C. Feger, M. M. Khojasteh und J. E. McGrath. Elsevier Science Publishers, Amsterdam 1989. 788 S., Abb., Tab., geb. $ 241.50. ISBN 0-444-88241-3." Nachrichten aus Chemie, Technik und Laboratorium 38, no. 3 (1990): 362–63. http://dx.doi.org/10.1002/nadc.19900380319.

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Vuaroqueaux, Vincent, Daniel Feger, Anne-Lise Peille, et al. "Abstract 1132: A systems biology approach combining ProLiFiler and Cancer Data Miner for an enhanced preclinical characterization of the WEE-1 inhibitor Adavosertib." Cancer Research 82, no. 12_Supplement (2022): 1132. http://dx.doi.org/10.1158/1538-7445.am2022-1132.

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Abstract Adavosertib (AZD1775, MK-1775), a clinical stage inhibitor of the tyrosine kinase WEE1, was investigated in a cell proliferation and survival assay with 140 human cancer cell lines (CLs) representing all major tumor types (ProLiFiler platform of Reaction Biology) followed by mechanism of action (MoA) and biomarker analyses using 4HF Biotec’s Cancer Data Miner in silico platform. Adavosertib exhibited a broad anti-cancer activity across all hematological and solid tumor types with IC50 values ranging from 0.06 to 10 µM (median: 0.38 µM), matching the consistently high expression of the

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Castro, Carla N., Daniel Feger, Sarah Ulrich, Oliver Siedentopf, and Jan E. Ehlert. "Abstract 2893: Exploring the combinatorial potential of bispecific T-cell engagers in high throughput format." Cancer Research 82, no. 12_Supplement (2022): 2893. http://dx.doi.org/10.1158/1538-7445.am2022-2893.

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Abstract Bispecific antibodies are being explored as a means to modulate responses of the immune system to tumor infiltration. They are emerging as a growing class of immunotherapies with potential to further improve clinical efficacy and safety. Besides tumor-targeted and dual immunomodulators, the most important class of therapeutically relevant bispecific antibodies are engagers of cytotoxic immune cells to kill tumor cells. These are mainly engager of T-cells (BiTE´s), but also NK-cell engager several of which have entered clinics with Blinatumomab (anti-CD3/anti-CD19) being FDA-approved f

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Bernat, James L. "Book Review Intervening in the Brain: Changing Psyche and Society (Ethics of Science and Technology Assessment. Vol. 29.) By Reinhard Merkel, Gerard Boer, and Jörg M. Fegert, with four others. 533 pp. Berlin, Springer, 2007. $99. 978-3-540-46476-1." New England Journal of Medicine 357, no. 20 (2007): 2095–96. http://dx.doi.org/10.1056/nejmbkrev0706190.

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Holtorf, Kaja, Anne-Lise Peille, Daniel Feger, Vincent Vuaroqueaux, Jan Erik Ehlert, and Nadine Obier. "Abstract 5157: Development and evaluation of a high-throughput method for rapid detection of surface antigen expression in fixed cells." Cancer Research 84, no. 6_Supplement (2024): 5157. http://dx.doi.org/10.1158/1538-7445.am2024-5157.

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Abstract Cell surface proteins are increasingly considered in the development of novel anticancer agents, as demonstrated by recent clinical successes in the field of immuno-oncology and antibody-drug conjugates (ADCs). These conjugates specifically target antigens present on the surface of tumor cells, enabling the delivery of cytotoxic agents to specific tumor sites. During the preclinical development of such compounds, for example, when they are tested on a wide panel of cell lines, it is essential to have a rapid and reliable method for monitoring target expression and distribution. Comple

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Fimm-Todt, Franziska, Ezgi Dikici, Katharina Schaich, et al. "Abstract 549: Characterization of the selective inhibitory effect of KRas inhibitors in different cellular assay formats." Cancer Research 83, no. 7_Supplement (2023): 549. http://dx.doi.org/10.1158/1538-7445.am2023-549.

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Abstract The proto-oncogene KRas is a well-described small GTPase that functions as a molecular switch for major physiological signaling pathways involved in cell proliferation, differentiation and survival. It has been shown that activating mutations in KRas are among the most common oncogenic drivers of tumorigenesis. Missense mutations of KRas result in constitutive activation due to impaired hydrolysis of GTP which enhances tumor-promoting downstream signaling pathways. Most KRas mutations are located in exon 2 or 3 including the most frequently changed glycine 12 which is present in most

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Castro, Carla, Philipp Metzger, Daniel Feger, et al. "Abstract 4419: Use of luciferase-labeled target cells to explore immune cell killing in high throughput format in 2D and 3D co-cultures." Cancer Research 83, no. 7_Supplement (2023): 4419. http://dx.doi.org/10.1158/1538-7445.am2023-4419.

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Abstract With the development and approval of cutting-edge immune-based approaches for cancer treatment in recent years, the global immune-oncological (IO) pipelines have dramatically increased. To overcome the challenges of rising treatment resistance, new strategies are being developed pointing towards enhancing and sustaining T cell-mediated cytotoxicity, exploiting NK, monocytes and γδT cell killing capacity, and combinatorial therapies, among others. Examples of such strategies are the bispecific antibodies, which are mainly T-cell (BiTE) engagers, but also NK-cell engagers. In addition t

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Wright, W. W. "Advances in polyimide science and technology, proceedings of the fourth international conference on polyimides. Edited by C. Feger, M. M. Khojasteh and M. S. Htoo. Technomic Publishing Co. Inc., Pennsylvania, USA, 1993. pp. xi + 706, price SWfr238. ISBN 0-87762-983-8." Polymer International 33, no. 3 (1994): 342. http://dx.doi.org/10.1002/pi.1994.210330320.

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Vuaroqueaux, Vincent, Nadine Obier, Anne-Lise Peille, et al. "Abstract 4895: Introduction of a platform for preclinical profiling of drug conjugates: a case study with sacituzumab govitecan." Cancer Research 83, no. 7_Supplement (2023): 4895. http://dx.doi.org/10.1158/1538-7445.am2023-4895.

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Abstract Drug-conjugates are an emerging class of anticancer agents combining the cytotoxic activity of highly potent chemotherapeutic agents with the target specificity of an antibody, a small molecule or a peptide ligand directed against a cancer-associated protein. With nearly half a century of development, profound advancements have been made in the development of these therapeutics. The most advanced are antibody-drug conjugates (ADCs) with currently &gt;100 in development and 11 approved by the FDA. To facilitate preclinical evaluation of novel drug conjugates, Reaction Biology and 4

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Peille, Anne-Lise, Kaja Holtorf, Pablo Anton Garcia, et al. "Abstract 4708: Potency and selectivity of ERBB2-targeting antibody drug conjugates in vitro." Cancer Research 84, no. 6_Supplement (2024): 4708. http://dx.doi.org/10.1158/1538-7445.am2024-4708.

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Abstract Previously we have reported on the relevance of the joint ProLiFiler and Cancer DataMiner platforms when studying the antitumor efficacy of novel antibody-drug conjugates (ADCs), such as Sacituzumab govitecan. In this study, we use our platforms to investigate and compare the selectivity of two FDA-approved Trastuzumab-based ADCs targeting ERBB2: Kadcyla, the first-in-class ADC employing a microtubule inhibitor bound via a non-cleavable linker, and Enhertu, which combines a topoisomerase inhibitor with a protease-cleavable linker. We performed a cell proliferation and survival assay u

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Krueger, W., D. Feger, A. Friedman, T. Doan, and K. D’silva. "POS1498 COMORBIDITIES AND SAFETY EVENTS IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1106.1–1106. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2379.

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BackgroundSystemic lupus erythematosus (SLE) is a complex autoimmune disease with multiorgan involvement. High disease activity may drive the development of comorbidities and safety events in SLE.ObjectivesTo assess the prevalence of comorbidities and history of safety events at the time of Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) assessment and the incidence of newly diagnosed comorbidities and safety events post-SLEDAI assessment among a prevalent cohort of adult SLE patients ≥18 years old.MethodsThis was a retrospective observational cohort study using the OM1 SLE Regist

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Kleinert, S., P. Rapp, F. Schuch, et al. "AB0494 COGNITIVE IMPAIRMENT IN AXIAL SPONDYLOARTHRITIS?" Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1274–75. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1353.

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Background:There is some evidence that neuropsychiatric changes occur in systemic lupus(1) and rheumatoid arthritis(2). However, little is known regarding a possible disease-related impairment of cognitive abilities in axial spondyloarthritis (axSpA).Objectives:To evaluate patients with axSpA regarding cognitive impairments.Methods:Patients with axSpA attending two rheumatology practices were routinely evaluated by rheumatologists and underwent a computer-based memory and attention test (MAT) (3, 4) with subscale scores ranging from 0 (worst) to 15 (best). The results of short-term memory and

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Lynce, Filipa, Candace Mainor, Xue Geng, et al. "Abstract PD9-02: Peripheral immune subsets and circulating tumor DNA (ctDNA) in patients (pts) with residual triple negative breast cancer (TNBC) treated with adjuvant immunotherapy and/or chemotherapy (chemo): The OXEL study." Cancer Research 82, no. 4_Supplement (2022): PD9–02—PD9–02. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd9-02.

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Abstract Background: Poor clinical outcomes are noted in pts with TNBC who do not achieve a pathologic complete response (pCR). We characterized peripheral immune subsets and the role of minimal residual disease (MRD) detection via ctDNA in pts who participated in the OXEL study. Methods: OXEL (Opdivo® -XELoda ®) is a recently completed phase II open-label 3-arm randomized study of nivolumab (nivo), capecitabine (cape) or the combination as adjuvant therapy (tx) for pts with residual TNBC after appropriate neoadjuvant chemo. Residual disease was defined as ≥ 1.0 cm of primary tumor and/or noda

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Pintos Amengual, Gabriel. "Ciencia y náutica. Los textos de pilotaje del siglo XVIII." Vínculos de Historia Revista del Departamento de Historia de la Universidad de Castilla-La Mancha, no. 12 (June 28, 2023): 343–57. http://dx.doi.org/10.18239/vdh_2023.12.18.

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RESUMENEn este artículo se trata de analizar los textos de pilotaje utilizados en el siglo xviii y su adecuación a la ciencia del momento. Para ello, abordamos el estado de la ciencia mediante el establecimiento de los hitos que marcaron la evolución de la navegación astronómica científica y, por otra parte, realizamos el análisis comparativo de los textos, para finalmente determinar si estos adoptaron o no los adelantos de la ciencia náutica y en su caso el periodo transcurrido hasta incluirlos en los textos. Palabras clave: ciencia, náutica, astronomía de posición, textos náuticos Topónimos:

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Zhou, Xin, Thomas Hutsch, Lars Penter, Holger Rudolph, Steffen Ihlenfeldt, and Thomas Weißgärber. "Experimental and numerical analysis of damping behavior of iron graphite composite in machine tool joint." Journal of Vibration and Control, November 14, 2022, 107754632211383. http://dx.doi.org/10.1177/10775463221138379.

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Iron graphite (FeGr) composite is a potential design material for machine tools to increase vibration damping without additional energy. Previous studies focused on the isolated composite’s properties rather than their damping effect as a passive damper to assembled components. There is currently no effective model using real mode superposition (RMS) method for demonstrating the damping behavior of FeGr composites in a multi-material structure. This paper presents a local damping description for a finite element model with RMS assuming constant loss factor for all modes to simulate the damping

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Kang, Ting, Huaizhi Wang, Ting Wu, Jianchun Peng, and Hui Jiang. "Solar irradiance prediction based on self-attention recursive model network." Frontiers in Energy Research 10 (September 5, 2022). http://dx.doi.org/10.3389/fenrg.2022.977979.

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In recent years, with the continued development and popularity of sustainable energy sources and the increasing utilization of solar energy, accurate solar radiation prediction has become important. In this paper, we propose a new model based on deep learning, Feature-enhanced Gated Recurrent Unit, hereafter referred to as FEGRU, for solar radiation prediction. This model takes the source data with one-dimensional convolution and self-attention to feature attention and processes the data features, and then GRU performs feature extraction on solar irradiance data. Finally, the data dimensionali

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Ibrahim, Fabio, and Tom Kattenberg. "Die heuristische Gefährdungsbeurteilung – ein Fortbildungsansatz zur Verbesserung der Polizeiarbeit im Umgang mit Personen in psychischen Ausnahmezuständen." Forensische Psychiatrie, Psychologie, Kriminologie, February 1, 2024. http://dx.doi.org/10.1007/s11757-023-00818-z.

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ZusammenfassungZiel dieser Übersichtsarbeit ist die Diskussion des polizeilichen Umgangs mit psychisch erkrankten Personen und Personen in psychischen Ausnahmezuständen. Die Themenrelevanz wird anhand praktischer Beispiele sowie der Darstellung aktueller Forschungsergebnisse und -kontroversen aufgezeigt. Aufbauend auf der Schlussfolgerung von Lorey und Fegert (2021) zur notwendigen Verbesserung der polizeilichen Fortbildung werden Konzeptionsinhalte einer heuristischen Gefährdungsbeurteilung im Umgang mit Personen in psychischen Ausnahmezuständen abgeleitet. Ein dienststellenübergreifendes Aus

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Darras, Gilles. "Hans Feger (Hg.), Friedrich Schiller – Die Realität des Idealisten. 2006." Arbitrium 27, no. 1 (2009). http://dx.doi.org/10.1515/arbi.2009.021.

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Brennan, Susan. "Blind Swimmers." Calabash: a Journal of Caribbean Arts and Letters 3, no. 1 (2004). http://dx.doi.org/10.33682/bw8a-fegr.

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