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Rozprawy doktorskie na temat „Fibroblast formation”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Skelly, R. T. "The contribution of fibroblast phenotype to stricture formation in Crohn's disease." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398093.

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Daley, Sandra J. "Basic fibroblast growth factor mediates neointimal formation in porcine aortic explants." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ27902.pdf.

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Davies, Paul Andrew. "Studies on the regulation of marrow fibroblast colony formation and differentiation." Thesis, University of Sheffield, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364241.

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Gallego-Llamas, Jabier. "Retinoic acid and Fibroblast Growth Factors during segmentation and somite formation." Université Louis Pasteur (Strasbourg) (1971-2008), 2007. http://www.theses.fr/2007STR13249.

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Au cours de la somitogénèse, l’action combinée d’un oscillateur moléculaire et la progression d’un front de détermination conduit à la formation périodique et synchronisée des somites. La régulation de la somitogénèse est sous le contrôle de plusieurs voies de signalisation dont les voies Notch, Wnt et Fgf. Récemment nous avons montré l’importance de l’acide rétinoïque (AR) dans cette cascade pour le positionnement correct des frontières somitiques de la synchronisation gauche/droite des oscillations moléculaires. L’asymétrie induite par la déficience en AR semble entre autre passer par la rég

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Manrique, Zuñiga Santiago. "Structural and computational studies of fibroblast growth factor receptor signalling complex formation." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:b6ccd433-f59b-40e6-838e-70aec5553caf.

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Fibroblast growth factor receptor (FGFR) signalling plays a crucial role in embryogenesis, adult tissue development and tissue repair. It has been implicated in a wide range of human pathologies such as cancers and skeletal disorders which is the reason for a particular interest over recent years. Concerted efforts in academia and industry are targeting the FGFR signalling networks at different stages. The intracellular canonical downstream signalling pathways in healthy and pathogenic cells are relatively well understood. A definition of the precise mechanism for ligand induced FGFR dimerisat

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6

Hamade, Fares. "Enhanced bone formation during distraction osteogenesis in FGFR3 deficient mice." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112630.

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Distraction Osteogenesis (DO) is a technique for bone lengthening and filling of bone defects following trauma, infection or resection of tumors. DO consists of an osteotomy of the bone to be lengthened, followed by controlled distraction of the bone segments with an external fixator until the desired lengthening is obtained (distraction phase). This is followed by the consolidation phase, during which the external fixator is kept in place until the newly formed bone in the distracted zone consolidates. This phase is long and may cause numerous problems. Ongoing research aims at finding a meth

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Mohammed, T. "Evaluating the effects of acoustic stimulation on fibroblast cell migration and muscle fibre formation." Thesis, Liverpool John Moores University, 2017. http://researchonline.ljmu.ac.uk/6047/.

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Cells are known to interact and respond to external mechanical cues and recent work has shown that application of mechanical stimulation, delivered via acoustic vibration, can be used to control complex cell behaviours. Much of the work in this area has focused on the effects of mechanical stimulation upon bone cells. Very little has been done to investigate the effects of mechanical stimulation on other cell types. Therefore, could mechanical stimulation be used to accelerate the wound healing process? Could mechanical stimulation be used to encourage muscle cell growth? The data generated in

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8

Mseka, T. "Behaviour, formation and function of oriented actin filament bundles in the establishment of fibroblast polarity." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1318097/.

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To establish morphological polarity, a cell must form a rear that is distinct from its front. For subsequent directional migration it must continuously retract its rear and protrude its front, polarised in the direction of migration. Here, two methods for the analysis of the transition from a pre-polar to a polarised state are used; spontaneous and cue dependant polarisation. Time-lapse microscopy of primary chick embryo heart fibroblasts expressing GFP-actin showed that, prior to cell polarization, actin filament bundles in the cell body reorganise to form oriented filament bundles spanning t

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9

Marui, Akira. "Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation." Kyoto University, 2005. http://hdl.handle.net/2433/144737.

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Albishi, Waleed. "Inhibition of fibroblast growth factor receptor 3 (FGFR3) signalling to accelerate bone formation during distraction osteogenesis of mice tibiae." Thesis, McGill University, 2014. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=121465.

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Distraction osteogenesis (DO) is a surgical technique widely used for the treatment of limb length discrepancies, limb deformities, long bone nonunions, and bone loss. The technique involves performing an osteotomy and then gradually distracting the two bone segments with an external fixator. This generates new bone within the distracted gap. Although very successful, one of the limitations of this technique is the long period of time the external fixator needs to be kept on, until the newly formed bone in the distracted zone consolidates. This prolonged process may lead to numerous social, ps

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11

Tabata, Yasuhiko. "De Novo Formation of Adipose Tissue by Controlled Release of Basic Fibroblast Growth Factorに関する研究". Kyoto University, 2002. http://hdl.handle.net/2433/149739.

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R, Lavoie Roxane. "L’activation du PDGFR favorise le phénotype agressif des synoviocytes de patients atteints de polyarthrite rhumatoïde via la formation d’invadosomes." Mémoire, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/10509.

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La polyarthrite rhumatoïde (PR) est une maladie auto-immune qui mène à une inflammation chronique et à une destruction progressive des articulations. Les effecteurs principaux de cette pathologie sont les synoviocytes de type fibroblastique (FLS). Ces derniers utilisent les invadosomes, des structures riches en actine et en métalloprotéases, afin de dégrader la matrice extracellulaire (ECM). Ce phénotype pro-destructif résulte d’une activation des FLS par différents facteurs de croissance, dont le PDGF et le TGF-β. Les récepteurs à activité tyrosine kinase, dont le PDGFR, sont impliqués dans l

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13

Raible, Florian. "Patterning of the embryonic vertebrate Brain in Response to Fibroblast Growth Factor Signaling." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1057576682343-32107.

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The term &quot;pattern formation&quot; refers to the process by which order unfolds in development. The present thesis deals with a particular aspect of molecular pattern formation during vertebrate embryogenesis. The model system in the focus of this study is the zebrafish, Danio rerio. In the early developmental phases of the zebrafish, Fibroblast growth factors (Fgfs) are involved in the molecular patterning of various tissues, including two regions of the brain, the forebrain and the midbrain-hindbrain region, affecting cellular processes as diverse as cell proliferation, different

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14

Rutherford, Claire. "The role of platelet derived growth factor-BB and basic fibroblast growth factor in neo-intimal and fatty streak formation in models of experimental atherosclerosis." Thesis, Queen Mary, University of London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313562.

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Schlick, Susanne [Verfasser], Wolfram-Hubertus [Akademischer Betreuer] Zimmermann, Ralf [Gutachter] Dressel, et al. "Fibroblast-Cardiomyocyte Cross-Talk in Heart Muscle Formation and Function / Susanne Schlick ; Gutachter: Ralf Dressel, Stefan Luther, Thomas Meyer, Rüdiger Behr, Antje Ebert ; Betreuer: Wolfram-Hubertus Zimmermann." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1177361744/34.

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Jarosz, Camille. "Rôle de l'EMMPRIN, inducteur des MMPs,dans l'activation des fibroblastes : conséquences sur la formation du stroma tumoral." Thesis, Paris Est, 2014. http://www.theses.fr/2014PEST0064.

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Les fibroblastes activés qui composent les stromas tumoraux sont des acteurs majeurs des interactions tumeur-stroma impliquées dans la croissance et la dissémination des cellules tumorales. Ce processus d'activation des fibroblastes est caractérisé par l'expression de marqueurs protéiques spécifiques parmi lesquels figure l'alphaSMA et FAPalpha;. Le TGFbeta;, cytokine secrétée massivement par les cellules tumorales, est un des éléments impliqués dans l'activation des fibroblastes et la formation du stroma tumoral qui en résulte. L'EMMPRIN, glycoprotéine transmembranaire surexprimée dans les ce

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Kiezel-Tsugunova, Magdalena. "Elucidating the metabolism of n-3 polyunsaturated fatty acids and formation of bioactive lipid mediators in human skin." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/elucidating-the-metabolism-of-n3-polyunsaturated-fatty-acids-and-formation-of-bioactive-lipid-mediators-in-human-skin(773abedd-c726-4dab-890a-694a96b1c074).html.

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Human skin has distinct lipid metabolism and production of bioactive lipid mediators that can be modulated by nutritional supplementation with omega-3 polyunsaturated fatty acids (n-3 PUFA), of which eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids exert anti-inflammatory effects. The aims of this project were to gain better understanding of their individual mechanisms in human epidermis and dermis. HaCaT keratinocytes, 46BR.1N fibroblasts, primary human epidermal keratinocytes and dermal fibroblasts were treated with EPA or DHA for 72h and then sham-irradiated or exposed to 15 mJ/cm2 ul

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18

Liu, Dan. "The role of senescent fibroblasts in tumor formation : a dissertation /." San Antonio : UTHSC, 2006. http://proquest.umi.com/pqdweb?did=1257790121&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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Ahlfors, Jan-Eric Wilhelm. "A Comparative Analysis of the Biomechanics and Biochemistry of Cell-Derived and Cell-Remodeled Matrices: Implications for Wound Healing and Regenerative Medicine." Link to electronic thesis, 2004. http://www.wpi.edu/Pubs/ETD/Available/etd-0503104-172949/.

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Thesis (M.S.) -- Worcester Polytechnic Institute.<br>Keywords: tension; failure strain; fibroblasts; regenerative medicine; serum-free; proteoglycans; glycosaminoglycans; collagen; wound-healing model; cell-remodeled matrix; cell-derived matrix; biomechanical characterization; fibrin gel; growth factors; tissue growth; total protein content; tissue formation. Includes bibliographical references (p.44-53).

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20

Begey, Anne-Laure. "Rôle du tissu adipeux cutané dans la formation et la cicatrisation de plaies de compression au cours de l'obésité." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1106.

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L’obésité et le diabète sont associés à des complications, notamment une fragilité cutanée. Celle-ci pourrait être associée à une altération du métabolisme du glucose et à une augmentation du tissu adipeux sous-cutané. Il a été montré que l’hypoderme pourrait avoir une fonction spécifique pour la peau. Notre travail a consisté d’une part à caractériser l’adiposité hypodermique et à étudier son influence dans la réactivité du tissu cutané en réponse à des pressions faibles ou fortes chez des souris obèses et d’autre part à étudier le processus de cicatrisation. Les fortes pressions augmentent l

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Gilbert, P. X. "Study of the role of an oncogene in the formation of tumours." Thesis, University of Oxford, 1986. http://ora.ox.ac.uk/objects/uuid:62fe804d-1208-454a-96cb-608c2491631b.

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The aim of this study was to examine the claim that a single, mutant oncogene can transform NIH 3T3 mouse fibroblasts into transformed, tumorigenic cells, acting in a genetically dominant fashion. A c.Ha-ras 1 oncogene, cloned from the EJ human bladder carcinoma cell line, was inserted into a shuttle vector carrying the selectable marker gene gpt, which encodes the enzyme XPRT (xanthine-guanine phosphoribosyl transferase). This construct, pSV2gptEJ, was transfected into NIH 3T3 cells by the calcium phosphate precipitation method and cells which had incorporated the plasmid were selected by gro

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HIRATA, Hiroaki, Hitoshi TATSUMI, and Masahiro SOKABE. "Tension-Dependent Formation of Stress Fibers in Fibroblasts : A Study Using Semi-Intact Cells." The Japan Society of Mechanical Engineers, 2004. http://hdl.handle.net/2237/9066.

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Atieh, Youmna Marie Lyne. "Interplay between cancer cells and cancer-associated fibroblasts in tumor invasion and metastasis formation." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066140/document.

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Les carcinomes sont des cancers touchant plusieurs organes du corps humain, notamment les seins, le pancréas, les poumons, l'intestin… et sont issus de la transformation de cellules épithéliales en cellules tumorales. Au cours du développement d'une tumeur, les cellules cancéreuses, contrairement aux cellules normales, acquièrent la capacité de se déplacer dans le corps humain, jusqu'à coloniser des organes voisins. Ces colonies sont appelées métastases. Le processus métastatique est responsable de 90% des décès dans le cadre des carcinomes. Ce processus n'est pas dû à l'action isolée des cell

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Atieh, Youmna Marie Lyne. "Interplay between cancer cells and cancer-associated fibroblasts in tumor invasion and metastasis formation." Electronic Thesis or Diss., Paris 6, 2017. http://www.theses.fr/2017PA066140.

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Les carcinomes sont des cancers touchant plusieurs organes du corps humain, notamment les seins, le pancréas, les poumons, l'intestin… et sont issus de la transformation de cellules épithéliales en cellules tumorales. Au cours du développement d'une tumeur, les cellules cancéreuses, contrairement aux cellules normales, acquièrent la capacité de se déplacer dans le corps humain, jusqu'à coloniser des organes voisins. Ces colonies sont appelées métastases. Le processus métastatique est responsable de 90% des décès dans le cadre des carcinomes. Ce processus n'est pas dû à l'action isolée des cell

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Suarez, Pozos Edna. "The effect of skin tension on the formation of keloid scars." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-effect-of-skin-tension-on-the-formation-of-keloid-scars(6762b081-6818-441b-98e6-6a74ae7b50da).html.

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Keloid scars (KS) are a type of abnormal scarring which is unique to humans. They extend beyond the confines of the original wound margins, do not regress over time and invade the surrounding unaffected skin. The mechanisms involved in the formation of KS remain largely unknown. Clinical observation has shown that in areas where increased tension occurs, such as the sternum, there is a greater propensity for developing KS. However, the precise relationship between skin tension and KS development is yet to be identified. In view of this, I hypothesize that skin tension plays a significant role

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Saccone, Marjorie. "TNF-α et transition endothélio-mésenchymateuse : implication dans la formation des fibroblastes associés au cancer (CAF)". Thesis, Aix-Marseille, 2019. http://theses.univ-amu.fr.lama.univ-amu.fr/191118_SACCONE_754fgtpw727krvu437zji770lpz_TH.pdf.

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L’adénocarcinome ductale pancréatique (ADP) est une tumeur avec un mauvais pronostic qui s’explique par un diagnostic tardif, une forte agressivité et une résistance aux thérapies. Il est caractérisé par la présence d’un stroma desmoplastique très dense responsable de l’hypo-vascularisation et impliqué dans la résistance aux thérapies. Il est principalement constitué de cellules immunitaires, endothéliales et de fibroblastes associés au cancer (CAF). Les CAF sont à l’origine de la desmoplasie et sont impliqués dans la progression tumorale. La transition endothélio-mésenchymateuse (EndMT) est u

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Owyoung, Jeremy B. "Bioactive coating glass and commercial bioglass enhance gene expression, protein expression, and matrix formation of human Periodontal Ligament Fibroblasts during osteogenesis." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1465487.

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Fernández, Muiños Maria Teresa. "Effect of the microenvironment in the in vitro chondrogenic and osteogenic differentiation of mouse embryonic fibroblasts." Doctoral thesis, Universitat Ramon Llull, 2014. http://hdl.handle.net/10803/134131.

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Durant els últims anys, el nostre grup s’ha centrat en l’estudi de models experimentals de formació de cartílag i ós amb l’objectiu d’entendre els paràmetres biomecànics i biològics que regulen la formació dels teixits que formen l’esquelet. En particular, resultats previs obtinguts en el nostre laboratori indiquen que quan els fibroblasts embrionaris de ratolí (de l’anglès, “mouse embryonic fibroblasts”, MEFs) es cultiven in vitro en el pèptid auto-ensamblable RAD16-I, emprant un sistema de cultiu tridimensional (3D), els MEFs són capaços d’adquirir una capacitat de diferenciació multipotenci

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Abbasi, Nooshin. "Searching for molecular mechanisms sustaining tumor formation and progression in Neurofibromatosis type 1." Doctoral thesis, Università degli studi di Padova, 2015. http://hdl.handle.net/11577/3424249.

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SUMMARY Neurofibromatosis type 1 (NF1, OMIM # 162200), also known as von Recklinghausen, is an autosomal dominant disease caused by mutations of the NF1 gene coding a 2818 amino acid protein, neurofibromin (Nf1). More than 900 different mutations in the NF1 gene have been identified (HGMD, Human Genetic Mutation Database). Mutations of NF1 gene cause a variety of clinical manifestations such as the optic gliomas, neoplasms of the haematopoietic system and learning disabilities. However, the hallmark of NF1 is the development of multiple benign peripheral nerve sheath tumors called neurofibrom

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Sahuc, Florent. "Étude de l'influence des fibroblastes sur la différenciation des kératinocytes et la formation de la jonction dermo-épidermique dans un modèle de peau reconstruite in vitro." Lyon 1, 1995. http://www.theses.fr/1995LYO1T278.

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Naue, Janine. "Histologische Charakterisierung eines murinen Knorpeldestruktionsmodells in der BALB/c Maus." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-184744.

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Die rheumatoide Arthritis ist eine chronisch-entzündliche Bindegewebserkrankung mit symmetrischem Befall der Gelenke. Die genaue Ätiologie ist bisher unbekannt. Aktivierte synoviale Fibroblasten sollen durch gesteigerte Adhäsion und Produktion von proinflammatorischen Zytokinen und Matrix-lysierenden Proteasen maßgeblich an der Gelenkdestruktion beteiligt sein. Ziel dieser Arbeit war es, ein neues in-vivo-Knorpeldestruktions-Modell zu etablieren, in welchem unter immunkompetenten Bedingungen, die Invasion und Destruktion von Gelenkknorpel durch die Fibroblasten-Zelllinie LS48 über einen länger

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Schlick, Susanne. "Fibroblast-Cardiomyocyte Cross-Talk in Heart Muscle Formation and Function." Doctoral thesis, 2018. http://hdl.handle.net/11858/00-1735-0000-002E-E57D-3.

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Srisailam, Sampath, and 隋賽仁. "Structure, Folding and Amyloid formation in Newt (Notophthalmus viridescens) Acidic Fibroblast Growth Factor." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/95556377378219202307.

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博士<br>國立清華大學<br>化學系<br>90<br>The three dimensional solution structure of an acidic fibroblast growth factor (nFGF-1) from the newt (Notopthalmus Viridescens) is determined using multidimensional NMR techniques. Complete assignment of the all atoms (1H, 15N and 13C) has been achieved using a variety of triple resonance experiments. A total of 50 structures were calculated by means of hybrid distance geometry-dynamical simulated annealing using a total of 1296 constraints. The atomic root mean square distribution for the 12 structures is 0.65 Å for the backbone atoms in the structured region.

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Shih-YuLu and 陸詩羽. "Role of Fibroblast Growth Factor 9 in Neurosphere Formation of Adipose-derived Stem Cells." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ncpa65.

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碩士<br>國立成功大學<br>細胞生物與解剖學研究所<br>105<br>Adipose-derived stem cells (ASCs) were an ideal cell source for stem cell therapy can promote nerve regeneration after injury. The fibroblast growth factor 9 (FGF9) can alter the proliferation and cell-fate decision in stem cells. In my project, we aim to investigate the role of FGF9 during neurosphere formation of ASCs. We used chitosan- coated dish to culture ASCs to induce sphere formation with or without addition of FGF9. The expression of gene was detected by PCR and the protein expression level was observed by Western blot and IF staining. Besides, w

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Page, Jonathan Michael. "Formation and Characterization of Polymerized Supported Phospholipid Bilayers and the in vitro Interactions of Macrophages and Fibroblasts." 2010. http://trace.tennessee.edu/utk_gradthes/736.

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Planar supported, polymerized phospholipid bilayers (PPBs) composed of 1,2-bis[10-(2’,4’-hexadienoyloxy)decanoyl]-sn-glycero-3-phosphocholine (bis-SorbPC or BSPC) were generated by a redox polymerization method. The PPBs were supported by a silicon substrate. The PPBs were characterized and tested for uniformity and stability under physiological conditions. The PPBs were analyzed in vitro with murine derived cells that are pertinent to the host response. Cellular attachment and phenotypic changes in RAW 264.7 macrophages and NIH 3T3 fibroblasts were investigated on PPBs and compared to bar

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St-Pierre, Jean-Philippe. "The Role of Inorganic Polyphosphate in the Formation of Bioengineered Cartilage Incorporating a Zone of Calcified Cartilage In Vitro." Thesis, 2012. http://hdl.handle.net/1807/33860.

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The development of bioengineered cartilage for replacement of damaged articular cartilage has gained momentum in recent years. One such approach has been developed in the Kandel lab, whereby cartilage is formed by seeding primary articular chondrocytes on the top surface of a porous biodegradable calcium polyphosphate (CPP) bone substitute, permitting anchorage of the tissue within the pores of the substrate; however, the interfacial shear properties of the tissue-substrate interface of these biphasic constructs are 1 to 2 orders of magnitude lower than the native cartilage-subchondral bone in

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Rho, Ho Kyung. "A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation." Diss., 2011. http://hdl.handle.net/10161/3819.

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<p>Specification and differentiation of a cell is accomplished by changing its gene expression profiles. These processes require temporally and spatially regulated transcription factors (TFs), to induce the genes that are necessary to a specific cell type. In each cell a set of TFs interact with each other or activate their targets; as development progresses, transcription factors receive regulatory inputs from other TFs and a complex gene regulatory network (GRN) is generated. Adding complexity, each TF can be regulated not only at the transcriptional level, but also by translational, and pos

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Ribeiro, Gabriela Sampaio. "Unraveling the interplay between fibroblasts and osteosarcoma cells during lung metastasis formation." Master's thesis, 2021. http://hdl.handle.net/10316/98774.

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Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>Introdução: O osteossarcoma (OS) é um tumor primário maligno que usualmente metastiza para o pulmão. Evidências crescentes sugerem que o tumor primário promove alterações fenotípicas nos fibroblastos pulmonares residentes, formando um nicho pré-metastático que favorece a colonização e desenvolvimento de metástases pulmonares. Posto isto, avaliámos a modulação do microambiente pulmonar e os efeitos recíprocos dos fibroblastos ativados sobre as células tumorais antes da colonização do pulmão. Materiais e mét

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Burl, Lana R. "Vitamin C and collagen IV formation in fibroblasts." 2007. http://proquest.umi.com/pqdweb?did=1240709521&sid=3&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (M.S.)--State University of New York at Buffalo, 2007.<br>Title from PDF title page (viewed on July 13, 2007) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Kuo, Shiu-Ming. Includes bibliographical references.

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Tsai, Chia-Lun, and 蔡佳倫. "Regulation of pulp fibroblasts on the formation of odontoclast-like multinucleated cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/63699633546998692814.

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碩士<br>國立陽明大學<br>牙醫學系<br>104<br>Root resorption is the loss of dentin and/or cementum as a result of odontoclastic action. Clinically, root resorption might result in loss of tooth structure, reduction of strength, even root fracture. However, little is known about the pathogenesis of this inflammatory process. While tumor necrosis factor-α (TNF-α) is one of the most potent osteoclastogenic cytokines, we used TNF-α as an inflammatory mediator to simulate an inflammatory model in this study. The aims of this study were to examine the secretion of odontoclastogenesis-associated inflammatory facto

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Cho, Ke-Huan, and 卓克桓. "The Protein Tyrosine Phosphatase SHP2 Suppresses the Formation of Podosome Rosettes in Src-transformed Fibroblasts." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/bc7h63.

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碩士<br>國立中興大學<br>生命科學系所<br>100<br>Podosomes are actin-enriched membrane protrusions that are important for matrix degradation and invasive cell motility. They are often found to organize into large rosette-like structures in Src-transformed fibroblasts, osteoclasts, endothelial cells, and some highly invasive cancer cells. Several protein tyrosine kinases have been reported to be important for the formation of podosome rosettes. However, little is known about the role of protein tyrosine phosphatases in this regards. In this study, we found that knockdown of the non-receptor protein tyrosine ph

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Kilic, Mehtap. "Formation of caspase activating complexes and activation of caspase-12 during apoptosis in AKR-2B mouse fibroblasts." Doctoral thesis, 2002. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-7190.

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Der Zelltod kann in Dichte-arretierten AKR-2B Mausfibroblasten durch Entzug des Serums oder Behandlung mit Anisomycin induziert werden. Der Zelltod zeigt zwar die für die Apoptose typischen morphologischen Veränderungen der Zelle wie Zellfragmentierung und Chromatinkondensation jedoch fehlen andere apoptotische Charakteristika, wie die oligonukleosomale Fragmentierung der DNA oder Änderung des Membranpotentials der Mitochondria. Während der Apoptose wurde eine beachtliche DEVDase Aktivität nach- gewiesen, die einem einzelnen Enzym zugeordnet werden konnte. Dieses Enzym hatte typische Eigenscha

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Huang, Hui-yi, and 黃慧怡. "The effects of protect from UV light damage and formation of melanin of liquid Nattos on fibroblasts and melanoma." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/xgg492.

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碩士<br>靜宜大學<br>化粧品科學系碩士班<br>97<br>The six kinds of liquid natto treated with human skin fibroblast, Detroit 551 and melanoma B16F10. The cell viability of Detroit 551 and B16F10, defensive effect for UVB-induced damage of Detroit 551 and B16F10 before UVB irradiation, defensive effect for UVB-induced injury of Detroit 551 and B16F10 after UVB irradiation, Dopachrome content and melanin content of B16F10 with 0.01mg/ml ~ 50mg/ml of liquid black natto or liquid natto were investigated in this study. The results show that liquid black natto No.1, No.2, No.3 and liquid natto No.4, No.5 were 0.05mg/

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Peng, S. S., and 彭淑霞. "The Study of Classical Protein KInase C And Ca2+/Mg2+-Dependent Endonuclease in Arsenite-Induced Micronuclei Formation in Human Fibroblasts." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/16358878919645330263.

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碩士<br>國立清華大學<br>輻射生物研究所<br>86<br>Arsenic is the first identified human carcinogen. However, the carcinogenic mechanism of arsenic is not yet defined. Recently, it was showed that 4-h arsenite treatment induced Ca2+ accumulation, micronuclei (MN) formation in CHO-K1 cells. And EGTA (Ca2+ chelator) and H7 (500mM, PKC inhibitor) could reduce arsenite-induced MN formation in CHO-K1 cells. MN formation is an index of genotoxicity. In this study, the data showed that 4-h arsenite treatment cotr

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Kilic, Mehtap [Verfasser]. "Formation of caspase activating complexes and activation of caspase-12 during apoptosis in AKR-2B mouse fibroblasts / vorgelegt von Mehtap Kilic." 2003. http://d-nb.info/970419430/34.

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