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Artykuły w czasopismach na temat "Flavivirus"

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Qiu, Yang, Yan-Peng Xu, Miao Wang, et al. "Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes." Science Advances 6, no. 6 (2020): eaax7989. http://dx.doi.org/10.1126/sciadv.aax7989.

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Mosquito-borne flaviviruses infect both mammals and mosquitoes. RNA interference (RNAi) has been demonstrated as an anti-flavivirus mechanism in mosquitoes; however, whether and how flaviviruses induce and antagonize RNAi-mediated antiviral immunity in mammals remains unknown. We show that the nonstructural protein NS2A of dengue virus-2 (DENV2) act as a viral suppressor of RNAi (VSR). When NS2A-mediated RNAi suppression was disabled, the resulting mutant DENV2 induced Dicer-dependent production of abundant DENV2-derived siRNAs in differentiated mammalian cells. VSR-disabled DENV2 showed sever
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Wee, Sheena, Asfa Alli-Shaik, Relus Kek, et al. "Multiplex targeted mass spectrometry assay for one-shot flavivirus diagnosis." Proceedings of the National Academy of Sciences 116, no. 14 (2019): 6754–59. http://dx.doi.org/10.1073/pnas.1817867116.

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Targeted proteomic mass spectrometry is emerging as a salient clinical diagnostic tool to track protein biomarkers. However, its strong analytical properties have not been exploited in the diagnosis and typing of flaviviruses. Here, we report the development of a sensitive and specific single-shot robust assay for flavivirus typing and diagnosis using targeted mass spectrometry technology. Our flavivirus parallel reaction monitoring assay (fvPRM) has the ability to track secreted flaviviral nonstructural protein 1 (NS1) over a broad diagnostic and typing window with high sensitivity, specifici
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van den Elsen, Kaïn, Jun Ping Quek, and Dahai Luo. "Molecular Insights into the Flavivirus Replication Complex." Viruses 13, no. 6 (2021): 956. http://dx.doi.org/10.3390/v13060956.

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Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever viruses. Millions of people are infected with these viruses around the world each year. Vaccines are only available for some members of this large virus family, and there are no effective antiviral drugs to treat flavivirus infections. The unmet need for vaccines and therapies against these flaviviral infections drives research towards a better understanding of the epidemiology, biology and immunology of flaviviruses. In
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Wu, Bingan, Zhongtian Qi, and Xijing Qian. "Recent Advancements in Mosquito-Borne Flavivirus Vaccine Development." Viruses 15, no. 4 (2023): 813. http://dx.doi.org/10.3390/v15040813.

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Lately, the global incidence of flavivirus infection has been increasing dramatically and presents formidable challenges for public health systems around the world. Most clinically significant flaviviruses are mosquito-borne, such as the four serotypes of dengue virus, Zika virus, West Nile virus, Japanese encephalitis virus and yellow fever virus. Until now, no effective antiflaviviral drugs are available to fight flaviviral infection; thus, a highly immunogenic vaccine would be the most effective weapon to control the diseases. In recent years, flavivirus vaccine research has made major brea
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Heinz, Franz X., and Karin Stiasny. "Flaviviruses and flavivirus vaccines." Vaccine 30, no. 29 (2012): 4301–6. http://dx.doi.org/10.1016/j.vaccine.2011.09.114.

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Liao, Ching-Len, Yi-Ling Lin, Bi-Ching Wu, et al. "Salicylates Inhibit Flavivirus Replication Independently of Blocking Nuclear Factor Kappa B Activation." Journal of Virology 75, no. 17 (2001): 7828–39. http://dx.doi.org/10.1128/jvi.75.17.7828-7839.2001.

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ABSTRACT Flaviviruses comprise a positive-sense RNA genome that replicates exclusively in the cytoplasm of infected cells. Whether flaviviruses require an activated nuclear factor(s) to complete their life cycle and trigger apoptosis in infected cells remains elusive. Flavivirus infections quickly activate nuclear factor kappa B (NF-κB), and salicylates have been shown to inhibit NF-κB activation. In this study, we investigated whether salicylates suppress flavivirus replication and virus-induced apoptosis in cultured cells. In a dose-dependent inhibition, we found salicylates within a range o
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Habarugira, Gervais, Jasmin Moran, Jessica J. Harrison, et al. "Evidence of Infection with Zoonotic Mosquito-Borne Flaviviruses in Saltwater Crocodiles (Crocodylus porosus) in Northern Australia." Viruses 14, no. 5 (2022): 1106. http://dx.doi.org/10.3390/v14051106.

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The risk of flavivirus infections among the crocodilian species was not recognised until West Nile virus (WNV) was introduced into the Americas. The first outbreaks caused death and substantial economic losses in the alligator farming industry. Several other WNV disease episodes have been reported in crocodilians in other parts of the world, including Australia and Africa. Considering that WNV shares vectors with other flaviviruses, crocodilians are highly likely to also be exposed to flaviviruses other than WNV. A serological survey for flaviviral infections was conducted on saltwater crocodi
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Fontoura, Marina Alves, Rebeca Fróes Rocha, and Rafael Elias Marques. "Neutrophil Recruitment and Participation in Severe Diseases Caused by Flavivirus Infection." Life 11, no. 7 (2021): 717. http://dx.doi.org/10.3390/life11070717.

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Neutrophils are first-line responders to infections and are recruited to target tissues through the action of chemoattractant molecules, such as chemokines. Neutrophils are crucial for the control of bacterial and fungal infections, but their role in the context of viral infections has been understudied. Flaviviruses are important human viral pathogens transmitted by arthropods. Infection with a flavivirus may result in a variety of complex disease manifestations, including hemorrhagic fever, encephalitis or congenital malformations. Our understanding of flaviviral diseases is incomplete, and
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Gibbs, Tristan, and David J. Speers. "Neurological disease caused by flavivirus infections." Microbiology Australia 39, no. 2 (2018): 99. http://dx.doi.org/10.1071/ma18029.

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The Flavivirus genus contains dozens of species with varying geographical distributions. Most flavivirus infections in humans are asymptomatic or manifest as a non-specific febrile illness, sometimes accompanied by rash or arthralgia. Certain species are more commonly associated with neurological disease and may be termed neurotropic flaviviruses. Several flaviviruses endemic to Australia and our near northern neighbours are neurotropic, such as Murray Valley encephalitis virus, West Nile (Kunjin) virus and Japanese encephalitis virus. Flavivirus neurological disease ranges from self-limiting
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Reis, Vinicius Pinho dos, Markus Keller, Katja Schmidt, Rainer Günter Ulrich та Martin Hermann Groschup. "αVβ3 Integrin Expression Is Essential for Replication of Mosquito and Tick-Borne Flaviviruses in Murine Fibroblast Cells". Viruses 14, № 1 (2021): 18. http://dx.doi.org/10.3390/v14010018.

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The Flavivirus genus includes a number of important viruses that are pathogenic to humans and animals and are responsible for outbreaks across the globe. Integrins, a family of heterodimeric transmembrane molecules expressed in all nucleated cells mediate critical functions of cell physiology and cell cycle. Integrins were previously postulated to be involved in flavivirus entry and to modulate flavivirus replication efficiency. In the present study, mouse embryonic fibroblasts (MEF), lacking the expression of αVβ3 integrin (MEF-αVβ3−/−), were infected with four different flaviviruses, namely
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Rozprawy doktorskie na temat "Flavivirus"

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Shomiad, Shueb Rafidah Hanim. "Contribution of different components of innate and adaptive immunity to severity of flavivirus-induced encephalitis in susceptible and resistant hosts." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0199.

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[Truncate abstract] Flaviviruses are small, positive-stranded RNA viruses belonging to the family Flaviviridae. Flavivirus infection in humans could cause diseases ranging from febrile illnesses to fatal encephalitis. Mice provide a useful small animal model to study flavivirus-induced encephalitis in humans since mice also develop encephalitis during flavivirus infection. Some strains of mice have been shown to be resistant to flavivirus challenge and this resistance is conferred by a single autosomal dominant gene, designated as Flvr. Recently, OAS1b gene has been identified to be a gene can
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Khou, Cécile. "Etude du neurotropisme des Flavivirus neuropathogènes." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC305/document.

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Les Flavivirus neuropathogènes, tels que le virus de l’encéphalite japonaise (JEV), le virus West Nile (WNV), le virus de la fièvre jaune (YFV) et le virus Zika (ZIKV) causent des maladies neurologiques. Ces maladies sont dues à une infection des cellules du système nerveux central (CNS) par ces virus. Le CNS est un organe privilégié, isolé des agents pathogènes par une barrière entre le sang et le cerveau, appelée barrière hémato-encéphalique (BBB). Les Flavivirus neuropathogènes capables de traverser cette BBB afin d’atteindre leurs cellules cibles, localisées dans le CNS, sont neuroinvasifs
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Lequime, Sébastian. "Interactions flavivirus-moustiques : diversité et transmission." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066081/document.

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Les flavivirus sont des virus à ARN parmi lesquels certains sont des arbovirus transmis entre hôtes vertébrés par des vecteurs arthropodes, notamment des moustiques. L'interaction avec les moustiques est centrale dans la biologie des flavivirus par son influence sur leur diversité génétique et transmission, mais certains de ses aspects restent méconnus. Au cœur de cette thèse, des approches basées sur les « big data », générées par des technologies modernes ou par compilation de travaux plus anciens, ont éclairé d’un jour nouveau la complexité des relations moustique-flavivirus. En explorant d
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Lequime, Sébastian. "Interactions flavivirus-moustiques : diversité et transmission." Electronic Thesis or Diss., Paris 6, 2016. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2016PA066081.pdf.

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Les flavivirus sont des virus à ARN parmi lesquels certains sont des arbovirus transmis entre hôtes vertébrés par des vecteurs arthropodes, notamment des moustiques. L'interaction avec les moustiques est centrale dans la biologie des flavivirus par son influence sur leur diversité génétique et transmission, mais certains de ses aspects restent méconnus. Au cœur de cette thèse, des approches basées sur les « big data », générées par des technologies modernes ou par compilation de travaux plus anciens, ont éclairé d’un jour nouveau la complexité des relations moustique-flavivirus. En explorant d
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Grard, Gilda. "Génomique et évolution des flavivirus transmis par les tiques et découverte d'un nouveau lignage du genre flavivirus." Aix-Marseille 2, 2006. http://www.theses.fr/2006AIX20679.

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Gollins, S. W. "Mechanisms of flavivirus neutralization and cellular infection." Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355752.

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Dayaraj, Cecilia. "Molecular and immunological studies on flavivirus virulence." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279888.

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Carney, Jennifer. "Viral Determinants of Flavivirus Neurotropism in Humans." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526956.

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Pacca, Carolina Colombelli. "Screening de novos antivirais inibidores de flavivirus." Faculdade de Medicina de São José do Rio Preto, 2013. http://bdtd.famerp.br/handle/tede/201.

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Made available in DSpace on 2016-01-26T12:51:48Z (GMT). No. of bitstreams: 1 carolinacolombellipacca_tese.pdf: 2227429 bytes, checksum: 4bcc12b8c06f6322170e32bfccfc8fa1 (MD5) Previous issue date: 2013-11-01<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Introduction. Arboviruses, arthropod-borne viruses, are frequently associated with human outbreaks and represent a serious health problem. The genus Flavivirus, which includes both the Yellow Fever Virus (YFV) and Saint Louis Encephalitis Virus (SLEV), are important pathogens that result in high morbidity and mortality rate
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Singethan, Katrin. "Untersuchungen zur Inhibition Paramyxo- und Flavivirus-induzierter Membranfusion." kostenfrei, 2009. http://www.opus-bayern.de/uni-wuerzburg/volltexte/2009/3634/.

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Książki na temat "Flavivirus"

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Gregory, Bock, Goode Jamie, Novartis Foundation, and Novartis Institute for Tropical Diseases., eds. New treatment strategies for dengue and other flaviviral diseases. John Wiley & Sons, 2006.

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Sondra, Schlesinger, and Schlesinger Milton J, eds. The Togaviridae and Flaviviridae. Plenum Press, 1986.

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Shi, Pei-Yong. Molecular virology and control of flaviviruses. Caister Academic Press, 2012.

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M, Chambers Thomas, ed. The flaviviruses. Academic, 2004.

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M, Chambers Thomas, ed. The flaviviruses. Academic, 2004.

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Chambers, Thomas J. The Flaviviruses: Detection, Diagnosis and Vaccine Development. Elsevier, 2003.

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M, Chambers Thomas, Monath Aaron J, Maramorosch Karl, Murphy Frederick A, and Shatkin Aaron J, eds. Advances in virus research. Elsevier, 2004.

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M, Chambers Thomas, Monath Aaron J, Maramorosch Karl, Murphy Frederick A, and Shatkin Aaron J, eds. Advances in virus research. Oxford, 2003.

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Bock, Gregory, and Jamie Goode, eds. New Treatment Strategies for Dengue and Other Flaviviral Diseases. John Wiley & Sons, Ltd, 2006. http://dx.doi.org/10.1002/0470058005.

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Ruzek, Daniel, ed. Flavivirus Encephalitis. InTech, 2011. http://dx.doi.org/10.5772/847.

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Części książek na temat "Flavivirus"

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Contigiani, Marta S., Luis A. Diaz, and Lorena Spinsanti. "Flavivirus." In Arthropod Borne Diseases. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-13884-8_6.

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Harnett, Gerald B., and Julia A. Cattell. "Flavivirus." In PCR for Clinical Microbiology. Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9039-3_34.

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Gooch, Jan W. "Flavivirus." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13767.

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Westaway, Edwin G. "Flavivirus‡." In The Springer Index of Viruses. Springer New York, 2011. http://dx.doi.org/10.1007/978-0-387-95919-1_67.

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Reid, Hugh W., Herbert Weissenböck, and Károly Erdélyi. "Flavivirus Infections." In Infectious Diseases of Wild Mammals and Birds in Europe. Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118342442.ch9.

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Yu, Yufeng, Lulu Si, and Yu Meng. "Flavivirus Entry Inhibitors." In Advances in Experimental Medicine and Biology. Springer Singapore, 2022. http://dx.doi.org/10.1007/978-981-16-8702-0_11.

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Rice, Charles M., Ellen G. Strauss, and James H. Strauss. "Structure of the Flavivirus Genome." In The Togaviridae and Flaviviridae. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4757-0785-4_10.

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Colombarolli, Stella Garcia, Izabella Cristina Andrade Batista, Naiara Clemente Tavares, et al. "Peptide Microarrays for Flavivirus Diagnosis." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2732-7_14.

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Padmanabhan, R., N. Mueller, E. Reichert, et al. "Multiple Enzyme Activities of Flavivirus Proteins." In Novartis Foundation Symposia. John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470058005.ch6.

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Kümmerer, Beate M. "Establishment and Application of Flavivirus Replicons." In Advances in Experimental Medicine and Biology. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-8727-1_12.

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Streszczenia konferencji na temat "Flavivirus"

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Kravchuk, B. I., Ya A. Khlusevich, G. S. Chicherina, N. V. Tikunova, A. A. Kechin, and A. L. Matveev. "OMSK HEMORRHAGIC FEVER VIRUS NS1 PROTEIN: ROLE IN PATHOGENESIS." In XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-249.

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The role of the NS1 protein of tick-borne flaviviruses in disease pathogenesis is poorly investigated. In addition, there are no data on cross-reactivity of antibodies against NS1 proteins of different viruses from the tick-borne encephalitis virus group. These data are of particular interest for the monitoring of viral encephalitis with unknown etiology and studying the pathogenesis of the of neglected flavivirus infections carried by ticks.
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Silva, Stephanie, Barbara Santos, Mariana Gomes, et al. "Interference of EDTA on Flavivirus infectivity." In International Symposium on Immunobiologicals. Instituto de Tecnologia em Imunobiológicos, 2023. http://dx.doi.org/10.35259/isi.2023_58027.

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Chaley, M. B., Zh S. Tyulko, and V. A. Kutyrkin. "Specifics of Coding Sequences in the Flavivirus Genomes." In Mathematical Biology and Bioinformatics. IMPB RAS - Branch of KIAM RAS, 2018. http://dx.doi.org/10.17537/icmbb18.10.

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"Recognition of flavivirus species on the base of coding genome sequences." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-091.

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Chaley, M. B., Zh S. Tyulko, and V. A. Kutyrkin. "Fast Method to Recognize Flavivirus Species after Sequencing the Viral Genome." In Mathematical Biology and Bioinformatics. IMPB RAS - Branch of KIAM RAS, 2020. http://dx.doi.org/10.17537/icmbb20.12.

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Lisboa, Aline Rebeca de Magalhães, Hayla Thatielle Cardoso de Oliveira Costa, Lídia Deyse Costa Mendes, et al. "Neuroepidemiological and social risks in neonates related to Zika Virus." In IV Seven International Congress of Health. Seven Congress, 2024. http://dx.doi.org/10.56238/homeivsevenhealth-093.

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Zika virus (ZIKV), a flavivirus transmitted by Aedes aegypti, has emerged as a serious global health problem following the Zika fever epidemic in Brazil in 2015. Infection in pregnant women can lead to congenital Zika virus syndrome (CZVS), characterized by microcephaly and other severe neurological malformations in newborns. Primary prevention is crucial, given the association between ZIKV and severe neurological complications, requiring ongoing support for those affected.
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woo Kim, Chan, Se Hwan Ahn, and Taeseon Yoon. "Comparison of flavivirus using datamining-Apriori, K-means, and decision tree algorithm." In 2017 19th International Conference on Advanced Communication Technology (ICACT). IEEE, 2017. http://dx.doi.org/10.23919/icact.2017.7890130.

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Santos, Franciellen Machado dos, VIVIANE HORN DE MELO, AMANDA PELLENZ RUIVO, FERNANDA M. S. GODINHO, and RICHARD STEINER SALVATO. "DETECÇÃO MOLECULAR DE ALPHAVIRUS E FLAVIVIRUS EM PACIENTES DO RIO GRANDE DO SUL." In IV Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2024. http://dx.doi.org/10.51161/conamic2024/30268.

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Martins, Raquel, Carolina Cajaraville, Fernando Conte, and Márcia Arissawa. "Optimized production of monoclonal antibody used in Flavivirus immunoassays for different projects of vaccine development." In II Seminário Anual Científico e Tecnológico em Imunobiológicos. Instituto de Tecnologia em Imunobiológicos, 2014. http://dx.doi.org/10.35259/isi.sact.2014_28652.

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Lima, Michelle, Paloma Pêgo, Gabriel Silva, and Salvatore De Simone. "Identification of targeted epitopes of yellow fever virus based on homology with other species of flavivirus." In V Seminário Anual Científico e Tecnológico. Instituto de Tecnologia em Imunobiológicos, 2017. http://dx.doi.org/10.35259/isi.sact.2017_26145.

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Raporty organizacyjne na temat "Flavivirus"

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ต้นธีรวงศ์, อัญญรัตน์. การศึกษาลักษณะทางพันธุกรรมและความหลากหลายทางพันธุกรรมของเชื้อไวรัสอุบัติใหม่ Tembusu related flavivirus ในเป็ดในประเทศไทย. จุฬาลงกรณ์มหาวิทยาลัย, 2017. https://doi.org/10.58837/chula.res.2017.70.

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โรคไข่ลดในเป็ด (duck egg drop syndrome) เป็นโรคติดเชื้อไวรัสอุบัติใหม่ที่พบในเป็ด โดยเป็ดที่ติดเชื้อจะแสดงอาการไข่ลดอย่างรุนแรง และแสดงอาการทางระบบประสาทร่วมด้วย จัดเป็นโรคที่ทำให้เกิดความเสียหายในอุตสาหกรรมการเลี้ยงเป็ดเป็นอย่างมากในช่วงเวลาที่ผ่านมา โรคนี้มีสาเหตุจากเชื้อ Tembusu related flavivirus หรือ duck Tembusu virus (DTMUV) จัดอยู่ในสกุล Flavivirus วงศ์ Flaviviridae ในประเทศไทยพบการระบาดของโรคนี้ตั้งแต่ปีพ.ศ. 2555 อย่างไรก็ตามปัจจุบันยังไม่มีการศึกษาลักษณะทางพันธุกรรม และความหลากหลายทางพันธุกรรมของเชื้อไวรัสอุบัติใหม่ Tembusu related flavivirus ที่ระบาดในเป็ดในประเทศไทย ดังนั้นการวิจัย
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Paul, Satashree. Flavivirus and its Threat. Science Repository, 2021. http://dx.doi.org/10.31487/sr.blog.30.

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A number of studies found that the virus can activate the endothelial cells and affect the structure and function of the blood?brain barrier, promoting immune cell migration to benefit the virus nervous system target cells infected by flaviviruses.
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Fournier, Maurille J., and Thomas L. Mason. Structure and Expression of Genes for Flavivirus Immunogens. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada252662.

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Osuna-Ramos, Juan Fidel. Cholesterol-Lowering Drugs as Potential Antivirals: A Repurposing Approach against Flavivirus Infections. ResearchHub Technologies, Inc., 2025. https://doi.org/10.55277/researchhub.ybzadmac.1.

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Thongtan, Thananya, Poonlarp Cheepsunthorn, and Kiat Ruxrungtham. An analysis and studies expression of receptor molecule on microglia cells to inhibits infection of the cells from Japanese encephalitis virus : Research report (Year 2009). Chulalongkorn University, 2009. https://doi.org/10.58837/chula.res.2009.14.

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Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is a major cause of viral encephalitis in Asia. Even though the principle target cells for JEV in the central nervous system are neurons, the microglia is activated in response to JEV infection. This research aimed to investigate the relationship between JEV and microglial cells. The percentage of JEV infectivity in mouse microglial (BV-2) cell line at 8, 15 and 24 hr post infection was determined by flow cytometry. It was found that the percentage of infected cells were approximately 53.5, 71.3 and 83.6 respectively. The JEV bind
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