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Artykuły w czasopismach na temat „Follicular Thyroid Carcinoma”

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Data publikacji: 3 czerwca 2025
Data aktualizacji: 31 lipca 2025

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1

Diallo-Krou, Ericka, Jingcheng Yu, Lesley A. Colby та ін. "Paired Box Gene 8-Peroxisome Proliferator-Activated Receptor-γ Fusion Protein and Loss of Phosphatase and Tensin Homolog Synergistically Cause Thyroid Hyperplasia in Transgenic Mice". Endocrinology 150, № 11 (2009): 5181–90. http://dx.doi.org/10.1210/en.2009-0701.

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Approximately 35% of follicular thyroid carcinomas and a small fraction of follicular adenomas are associated with a t(2;3)(q13;p25) chromosomal translocation that fuses paired box gene 8 (PAX8) with the peroxisome proliferator-activated receptor-γ gene (PPARG), resulting in expression of a PAX8-PPARγ fusion protein, PPFP. The mechanism by which PPFP contributes to follicular thyroid neoplasia is poorly understood. Therefore, we have created mice with thyroid-specific expression of PPFP. At 1 yr of age, 25% of PPFP mice demonstrate mild thyroid hyperplasia. We bred these mice to mice with thyr
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Makazlieva, Tanja, Olivija Vaskova, Aleksandra Nikolovska, and Vesna Stefanovska. "Distribution of histopathological types of thyroid tumors in 1999-2015 compared to 1966-1988 year period." Archive of Oncology 26, no. 1 (2020): 1–5. http://dx.doi.org/10.2298/aoo190402005m.

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Background: The most common thyroid tumors originate from the epithelial follicular cells. Etiology involved in the development of thyroid carcinoma is multifactorial, including external influences and genetic predisposition. Aim: The objective of our study was to analyze the distribution of the histopathological types of thyroid carcinoma during 1999- 2015 year period, to evaluate papillary and follicular thyroid carcinoma ratio and to compare thyroid carcinoma types with the data from prior epidemiological study referring to the period from 1966 -1988. Methods: A retrospective analysis was p
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Montuori, Nunzia, Frank Müller, Stefano De Riu, et al. "Laminin Receptors in Differentiated Thyroid Tumors: Restricted Expression of the 67-Kilodalton Laminin Receptor in Follicular Carcinoma Cells1." Journal of Clinical Endocrinology & Metabolism 84, no. 6 (1999): 2086–92. http://dx.doi.org/10.1210/jcem.84.6.5721.

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The expression of integrin laminin receptors was investigated in normal thyroid primary cultures; immortalized normal thyroid cells (TAD-2); papillary (NPA), follicular (WRO), and anaplastic (ARO) thyroid tumor cell lines; seven thyroid tumors (four papillary and three follicular carcinomas); and normal thyroid glands. The expression of α1β1, α2β1,α 3β1, α6β1, andα 6β4 was found in all tumor specimens and in tumor cell lines, whereas normal thyroid cells and TAD-2 cells lacked the expression of α6β4. Despite the presence of several integrin laminin receptors, adhesion of TAD-2, NPA, and ARO ce
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4

Savell, Van H., Stephen M. Hughes, Charles Bower, and David M. Parham. "Lymphocytic Infiltration in Pediatric Thyroid Carcinomas." Pediatric and Developmental Pathology 7, no. 5 (2004): 487–92. http://dx.doi.org/10.1007/s10024-003-3028-3.

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Lymphocytic thyroiditis has been associated with an increase in the incidence of thyroid papillary carcinoma in some reports, mostly series of both adults and children. Relatively little is written about thyroiditis and follicular carcinomas. We have seen several cases of pediatric follicular thyroid carcinomas, that had an associated lymphocytic infiltrate, which led us to examine all primary malignant thyroid neoplasms in our surgical files from 1984 through 2000 to examine this relationship. We also investigated the nature of the lymphocytic infiltrate with routine immunohistochemistry. Ten
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5

Varghese, Alina Mariam, and Sankar, S. "Follicular Carcinoma Thyroid with Focus of Squamous Cell Carcinoma - A Case Report." Saudi Journal of Pathology and Microbiology 8, no. 03 (2023): 46–49. http://dx.doi.org/10.36348/sjpm.2023.v08i03.001.

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Collision tumors of the thyroid gland are a rare entity. Primary squamous cell carcinoma of the thyroid (PSCCT) is a malignant epithelial tumor, composed entirely of cells with squamous differentiation and accounting for less than 1% of all malignancies of the thyroid gland. PSCCT arises from other thyroid diseases such as Hashimoto’s thyroiditis, tall cell variant papillary carcinoma, follicular carcinoma, and anaplastic carcinoma1. We describe a patient with the combination of a well-differentiated squamous cell carcinoma and follicular carcinoma of the thyroid.
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6

Fan, Jing-Jing, and Qiang Chen. "Chest wall metastasis in postoperative thyroid cancer: a case report." Journal of International Medical Research 47, no. 8 (2019): 4039–42. http://dx.doi.org/10.1177/0300060519862455.

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Thyroid cancer is common in China. Thyroid adenocarcinoma metastases can be local or distal metastasis. Local metastasis presents as a hard and fixed lymph node in the neck, while distant metastases are found in the lung, skull, vertebrae, and pelvis. However, thyroid follicular carcinomas are mostly observed in hematogenous metastases. The thyroid adenocarcinoma and follicular carcinoma of the thyroid gland are often misdiagnosed. Here, we report the case of a 53-year-old female patient. More than 2 years after her initial diagnosis, her left chest wall was physically examined. The results re
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7

Kondo, Tetsuo, Nobuki Nakamura, Koichi Suzuki, et al. "Expression of Human Pendrin in Diseased Thyroids." Journal of Histochemistry & Cytochemistry 51, no. 2 (2003): 167–73. http://dx.doi.org/10.1177/002215540305100205.

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We examined pendrin expression in various diseased thyroid tissues by immunohistochemistry (IHC) using antiserum raised against human pendrin and by real-time quantitative RT-PCR. In normal thyroids the antiserum reacted with the apical membrane of follicular cells and its immunoreactivity was faint. In Graves’ thyroids, the IHC expression of pendrin appeared in a pattern similar to that of normal thyroids but it was more extensive and stronger, especially in areas showing marked proliferation of follicular cells. The immunoreactivities of pendrin in nodular goiters varied from case to case. I
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8

Revathi, Govindasamy, V. Sriram, Erli Amel Ivan, and Gandhi Ramya. "Differentiated High Grade Follicular Thyroid Carcinoma: Diagnostic Experience of New Entity - A Rare Case Report." Journal of Medical Sciences and Health 11, no. 1 (2025): 101–4. https://doi.org/10.46347/jmsh.v11.i1.24.181.

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Differentiated high-grade thyroid carcinoma (DHGTC) is a recently classified invasive high-grade follicular derived carcinomas that retain the architectural and cytologic features of well-differentiated follicular cell carcinomas with high-grade features like increased mitotic count and tumor necrosis. The prevalence of DHGTC in follicular thyroid carcinoma was found to be 0.146 [CI = 0.101-0.205]. To the best of my knowledge, this is the second case report of this new entity according to the recent WHO classification of Endocrine and Neuroendocrine tumours (2022). These tumors commonly presen
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9

Kitamura, Yutaka, Kazuo Shimizu, Koichi Ito, Shigeo Tanaka, and Mitsuru Emi. "Allelotyping of Follicular Thyroid Carcinoma: Frequent Allelic Losses in Chromosome Arms 7q, 11p, and 22q." Journal of Clinical Endocrinology & Metabolism 86, no. 9 (2001): 4268–72. http://dx.doi.org/10.1210/jcem.86.9.7853.

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The genetic mechanisms involved in development of follicular thyroid carcinoma are poorly understood, although allelic losses (LOH) in this type of tumor have been reported in small panels of follicular thyroid carcinomas examined in earlier studies. To clarify the real frequency of allelic loss we carried out a genome-wide allelotyping study of 66 follicular thyroid carcinomas using 39 microsatellite markers representing all nonacrocentric autosomal arms. The mean frequency of LOH was 9.2%, and the mean fractional allelic loss was 0.09. The most frequent allelic losses were detected in 7q (28
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10

Krgovic, Ksenija, Ivan Paunovic, Aleksandar Diklic, et al. "Follicular thyroid carcinoma." Acta chirurgica Iugoslavica 50, no. 3 (2003): 107–11. http://dx.doi.org/10.2298/aci0303107k.

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Follicular thyroid cancer is the second most common thyroid malignancy. This tumor has a predisposition for hematogenous dissemination an extrathyroid spread. Accurate cytological diagnosis of follicular thyroid cancer is not possible and this fact highlights the necessity for surgical treatment of any suspicious thyroid nodule. Aggressiveness of this tumor is greater than in the case of papillary thyroid cancer and it is the reason for radical surgical treatment of follicular thyroid cancer. Total thyroidectomy facilitates later adjuvant therapy with thyroid hormones and radioiodine. This pro
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11

Mazeh, Haggi, Amir Orlev, Ido Mizrahi, David J. Gross, and Herbert R. Freund. "Concurrent Medullary, Papillary, and Follicular Thyroid Carcinomas and Simultaneous Cushing's Syndrome." European Thyroid Journal 4, no. 1 (2014): 65–68. http://dx.doi.org/10.1159/000368750.

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Background: Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5-8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid gland are extremely rare and reported scarcely. Case Report: A 72-year-old male presented with nonspecific neck pain. The workup revealed a nodular thyroid gland with a follicular lesion on fine-needle aspiration. Total thyroidectomy was performe
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12

Ahn, Soomin, Tae Hyuk Kim, Sun Wook Kim, et al. "Comprehensive screening for PD-L1 expression in thyroid cancer." Endocrine-Related Cancer 24, no. 2 (2017): 97–106. http://dx.doi.org/10.1530/erc-16-0421.

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PD-L1 expression is being considered a potential biomarker for response of anti-PD-1 or anti-PD-L1 agents in various tumors. The reported frequency of PD-L1 positivity varies in thyroid carcinomas, and multiple factors may contribute to the variability in PD-L1 positivity. We evaluated the PD-L1 expression in various thyroid cancers on a large scale. A total of 407 primary thyroid cancers with a median 13.7-year of follow-up were included. We evaluated the frequency of PD-L1 expression using a rabbit monoclonal antibody (clone SP142). In addition, we analyzed the relationships between PD-L1 ex
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13

Zhang, Xuchen, and Constantine Axiotis. "Thyroid-Type Carcinoma of Struma Ovarii." Archives of Pathology & Laboratory Medicine 134, no. 5 (2010): 786–91. http://dx.doi.org/10.5858/134.5.786.

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Abstract Struma ovarii is a monodermal variant of ovarian teratoma. Thyroid-type carcinoma arising in struma ovarii is rare. The most common type is papillary carcinoma, followed by typical follicular carcinoma, and the new entity of follicular carcinoma—highly differentiated follicular carcinoma of ovarian origin; other forms occur rarely. Consensus on the surgical and postoperative treatment of patients with thyroid-type carcinoma arising in struma ovarii has not been reached. Surgical treatment ranges from total abdominal hysterectomy, plus bilateral salpingo-oophorectomy with omentectomy,
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14

Perveen, Rahima, Jasmin Ferdous, Sharmin Quddus, and Tapati Mandal. "Solitary Liver Metastasis from Follicular Variant Papillary Thyroid Carcinoma: A Case Report." Bangladesh Journal of Nuclear Medicine 22, no. 2 (2021): 146–49. http://dx.doi.org/10.3329/bjnm.v22i2.51768.

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Papillary and follicular thyroid carcinomas, together known as differentiated thyroid carcinomas (DTC), are among the most curable of cancers. Distant metastases are rare events at the onset of DTC. Sites of metastases from follicular thyroid cancer (FTC) are usually osseous, and those from papillary thyroid cancer (PTC) metastasize to regional nodal basins and the lungs. Visceral metastases are rare, but the involvement of multiple sites has been reported so far. Liver metastases from differentiated thyroid carcinoma (LMDTC) are rare.We present the case of a patient with follicular variant of
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15

Rossi, Esther Diana, William C. Faquin, and Liron Pantanowitz. "Aggressive Variants of Follicular- and Parafollicular-Derived Thyroid Carcinoma." AJSP: Reviews and Reports 24, no. 2 (2019): 61–71. http://dx.doi.org/10.1097/pcr.0000000000000297.

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Abstract There are several aggressive variants of thyroid carcinoma including those of papillary thyroid carcinoma, poorly differentiated thyroid carcinoma, anaplastic thyroid carcinoma, and medullary thyroid carcinoma that are important to recognize. Among thyroid malignancies, papillary thyroid carcinoma represents the most common form of endocrine cancer. Papillary thyroid carcinoma usually presents as an indolent cancer with high overall survival rates approaching 96%. However, a minority of thyroid carcinomas with distinctive histopathology (eg, tall cell, columnar cell, solid, hobnail, d
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16

Mäkinen, Tuulikki, Fredrika Pekonen, Kaarle Franssila, and Bror-Axel Lamberg. "Receptors for epidermal growth factor and thyrotropin in thyroid carcinoma." Acta Endocrinologica 117, no. 1 (1988): 45–50. http://dx.doi.org/10.1530/acta.0.1170045.

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Abstract. The EGF and TSH receptor properties in malignant thyroid tumours and adjacent normal thyroid tissues were characterized using radioreceptor assays. Ten patients with papillary, 4 with medullary, 1 with Hürthle cell type follicular carcinoma, and 2 with anaplastic thyroid carcinoma were studied. In 10 out of 12 patients with papillary and anaplastic thyroid carcinomas, more EGF receptors were found in the neoplastic tissue than in the adjacent normal tissue (P < 0.01). The affinity of the EGF receptors varied between patients (from 0.5 × 109 1/mol to 1.9 × 109 1/mol), but was in ea
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17

Lo, Chung-Yau, Wai-Fan Chan, King-Yin Lam, and Koon-Yat Wan. "Follicular Thyroid Carcinoma." Annals of Surgery 242, no. 5 (2005): 708–15. http://dx.doi.org/10.1097/01.sla.0000186421.30982.d2.

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Sobrinho-Simões, Manuel, Catarina Eloy, João Magalhães, Cláudia Lobo, and Teresina Amaro. "Follicular thyroid carcinoma." Modern Pathology 24, S2 (2011): S10—S18. http://dx.doi.org/10.1038/modpathol.2010.133.

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Haigh, Philip I. "Follicular thyroid carcinoma." Current Treatment Options in Oncology 3, no. 4 (2002): 349–54. http://dx.doi.org/10.1007/s11864-002-0034-z.

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Chow, Sin-Ming, Stephen C. K. Law, William M. Mendenhall, et al. "Follicular thyroid carcinoma." Cancer 95, no. 3 (2002): 488–98. http://dx.doi.org/10.1002/cncr.10683.

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Strumfa, Ilze, Didzis Gailis, Ervins Vasko, et al. "Spectrum of Surgically Treated Thyroid Carcinoma in Latvia." Acta Chirurgica Latviensis 13, no. 2 (2013): 3–8. http://dx.doi.org/10.2478/chilat-2014-0001.

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Abstract Introduction Health care statistics provides a solid evidence of increasing thyroid cancer prevalence in Latvia. However, in order to characterise the problem of thyroid cancer more completely, histological type and stage of carcinomas as well as demographic characteristics of the affected patients would be as important as the total burden of new cases. Aim of the study was to provide detailed characteristics of the spectrum of surgically treated primary thyroid carcinoma. Materials and methods. The study was designed as retrospective research. Archives of a single university hospital
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22

Tatic, Svetislav. "Histopathological and immunohistochemical features of thyroid carcinoma." Archive of Oncology 11, no. 3 (2003): 173–74. http://dx.doi.org/10.2298/aoo0303173t.

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Thyroid-specific malignant tumors are derived from follicle cells (papillary and follicular carcinoma), and from parafollicular, calcitonin-producing C-cells (medullary carcinoma). The main criterion for diagnosis of papillary carcinoma is the occurrence of ground glass, hypochromic nuclei, often associated with papillae as the prominent pattern of the tumor, and psammoma bodies. The diagnosis of follicular carcinoma is based on the true infiltration of the venous vessels outside the tumor capsule and the fungus-like infiltration through the tumor capsule into the surrounding parenchyma. Anapl
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El Harich, Walid, Joel Cedric Bayem, Edwin Kelly Haag, Hicham Fenane, and Yassine Msougar. "SINGLE RIB METASTASIS OF THYROID FOLLICULAR CARCINOMA: ABOUT02 CASES." International Journal of Advanced Research 11, no. 04 (2023): 256–60. http://dx.doi.org/10.21474/ijar01/16648.

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Follicular carcinoma is the second most common histological type of thyroid carcinoma and has a particular tropism for the bone. However, costal metastases remain rare events. We report two cases of unique costal metastases, the first of which is indicative and the second a late recurrence of thyroid follicular carcinoma. We performed in both cases a complete removal with parietal reconstruction followed by radioiodine therapy. No recurrences were recorded after 06 months of follow-up. This demonstrates the importance of surgery in the management of oligometastases during follicular thyroid ca
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Sofiadis, Anastasios, Susanne Becker, Ulf Hellman, et al. "Proteomic profiling of follicular and papillary thyroid tumors." European Journal of Endocrinology 166, no. 4 (2012): 657–67. http://dx.doi.org/10.1530/eje-11-0856.

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ObjectiveThyroid proteomics is a new direction in thyroid cancer research aiming at etiological understanding and biomarker identification for improved diagnosis.MethodsTwo-dimensional electrophoresis was applied to cytosolic protein extracts from frozen thyroid samples (ten follicular adenomas, nine follicular carcinomas, ten papillary carcinomas, and ten reference thyroids). Spots with differential expression were revealed by image and multivariate statistical analyses, and identified by mass spectrometry.ResultsA set of 25 protein spots significant for discriminating between the sample grou
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Cvejic, Dubravka, Svetlana Savin-Zegarac, Ivan Paunovic, Svetislav Tatic, and Marija Havelka. "Galectin-3: A promising marker of thyroid malignancy." Archive of Oncology 11, no. 3 (2003): 186. http://dx.doi.org/10.2298/aoo0303186c.

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Background: Galectin-3 is an endogenous beta-galactoside binding lectin implicated in neoplastic transformation and tumor progression. High levels of this lectin have recently been found in malignant thyroid tumors, but not in normal or benign thyroid tissue, suggesting galectin-3 as a promising presurgical marker of thyroid malignancy. Methods: We analyzed immunohistochemically galectin-3 expression in thyroid tissue using a monoclonal antibody. The total of 108 tissue specimens included 55 cases of thyroid carcinoma (30 papillary, 15 follicular, and 10 anaplastic type), 15 samples of follicu
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Majumder, Swapna, Khadiza Khanam, and Jesmin Jaz Ferdous. "Significance of Combined Immuno-histochemical Expression of P63 & CD56 in Papillary and Follicular Thyroid Carcinoma." Journal of Histopathology and Cytopathology 8, no. 2 (2024): 91–99. http://dx.doi.org/10.69950/jhc.2024.v8.i2.4.

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Background: Thyroid neoplasm is the commonest endocrine neoplasm. More than 80% of thyroid malignancies are papillary thyroid carcinoma (PTC) followed by follicular carcinoma (FC). The diagnosis of papillary thyroid carcinoma is based on characteristic nuclear morphology of a thyroid neoplasm. In contrast, follicular variant of PTC may cause, if the nuclear features of PTC are insufficiently appreciated, severe problems in differentiating from follicular thyroid carcinoma. Several immunohistochemical (IHC) markers such as P63 and CD56 have been recommended to differentiate between this two thy
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Pyo, Jung-Soo, Dong-Hoon Kim, and Jungho Yang. "Diagnostic value of CD56 immunohistochemistry in thyroid lesions." International Journal of Biological Markers 33, no. 2 (2018): 161–67. http://dx.doi.org/10.1177/1724600817748538.

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Purpose: The present study aimed to evaluate the diagnostic roles of CD56 immunohistochemistry in differentiating various thyroid lesions. Methods: A meta-analysis was performed to evaluate the rate of loss of CD56 immunohistochemistry expression from 13 eligible studies regarding various thyroid lesions, including papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. To confirm the value of CD56 immunohistochemistry in differentiating various thyroid lesions, a diagnostic test accuracy review was conducted. Results: An 87.8%, 79.1%, 11.9%, 25.5%, and 19.6% loss of CD56 im
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O'Donovan, N., A. Fischer, EM Abdo, et al. "Differential expression of IgG Fc binding protein (FcgammaBP) in human normal thyroid tissue, thyroid adenomas and thyroid carcinomas." Journal of Endocrinology 174, no. 3 (2002): 517–24. http://dx.doi.org/10.1677/joe.0.1740517.

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The genetic events involved in thyroid carcinogenesis are still incompletely understood. Several rearrangements and mutations of oncogenes have been implicated in the development of thyroid papillary carcinomas, follicular adenomas and carcinomas. However, none of these molecular alterations is suitable either as a general marker for the diagnosis of thyroid carcinomas or to differentiate between thyroid follicular adenomas and carcinomas. In order to identify new genes with altered expression which could serve as such markers, we analyzed RNA from thyroid tumor and normal tissue using a novel
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Herrmann, Marille E., Virginia A. LiVolsi, Theresa L. Pasha, Shelley A. Roberts, Eva M. Wojcik, and Zubair W. Baloch. "Immunohistochemical Expression of Galectin-3 in Benign and Malignant Thyroid Lesions." Archives of Pathology & Laboratory Medicine 126, no. 6 (2002): 710–13. http://dx.doi.org/10.5858/2002-126-0710-ieogib.

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Abstract Context.—The expression of galectin-3, a human lectin, has been shown to be highly associated with malignant behavior of thyroid lesions. Design.—We studied the immunohistochemical expression pattern of galectin-3 in a variety of follicular-derived thyroid lesions (13 benign and 62 malignant), including Hürthle cell and follicular carcinoma, papillary carcinomas and variants, and anaplastic and poorly differentiated carcinomas. Results.—Immunoreactivity was strongest in papillary thyroid carcinomas, whereas staining was less intense in Hürthle cell and anaplastic carcinomas, and even
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Faquin, William C. "The Thyroid Gland: Recurring Problems in Histologic and Cytologic Evaluation." Archives of Pathology & Laboratory Medicine 132, no. 4 (2008): 622–32. http://dx.doi.org/10.5858/2008-132-622-ttgrpi.

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Abstract Nodules of the thyroid gland are frequently encountered, occurring in up to 7% of the population, and although most of these nodules are benign, carcinomas of the thyroid gland are the most common malignancy of the endocrine system. Although the different types of thyroid carcinoma are few, a wide variety of recurring problems exists in both their histologic and cytologic evaluation. Here, I will review a selected group of problematic areas, including unusual histologic variants of follicular adenoma, criteria for diagnosing minimally invasive follicular carcinoma, the use of fine-nee
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Falvo, Laura, Antonio Catania, Vito D'Andrea, Paola Grilli, Claudia D'Ercole, and Enrico De Antoni. "Prognostic Factors of Insular versus Papillary/Follicular Thyroid Carcinoma." American Surgeon 70, no. 5 (2004): 461–66. http://dx.doi.org/10.1177/000313480407000516.

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The study aims were to characterize patients with insular thyroid cancer and to provide data on patient outcome after surgical therapy. We compared nine patients with insular thyroid cancer at the Department of Surgical Science of “La Sapienza” University of Rome with 27 patients of similar age and tumor size who had follicular and papillary cancer, for a minimum follow-up period of 24 months (range, 24–72 months). All of the patients examined underwent total thyroidectomy. Vascular invasion was observed in 44.4 per cent of insular carcinomas ( P < 0.05 vs papillary carcinomas). No signific
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Kalbuningwang, Gagang Guntaran, Dwi Hari Susilo, and Marjono Dwi Wibowo. "Correlation of Platelet-Lymphocyte Ratio towards the Incidence of Follicular Thyroid Carcinoma." International Journal of Research and Review 8, no. 9 (2021): 36–42. http://dx.doi.org/10.52403/ijrr.20210907.

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Background: Recently, there is some consistent evidence that the inflammatory process is related to the development and progression of cancer. Platelet-lymphocyte ratio (PLR) may acts as simple biomarker for predicting the occurrence of cancer. Since fine needle aspiration could not distinguish between follicular thyroid carcinoma and benign lesion, the researchers were interested in conducting research correlation of PLR towards incidence of follicular thyroid carcinoma in Dr Soetomo Hospital Surabaya. Methods: This study used secondary data from medical record of surgical pathology report di
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Hassan, Bardes B., Lucas A. Altstadt, Wessel P. Dirksen, Said M. Elshafae, and Thomas J. Rosol. "Canine Thyroid Cancer: Molecular Characterization and Cell Line Growth in Nude Mice." Veterinary Pathology 57, no. 2 (2020): 227–40. http://dx.doi.org/10.1177/0300985819901120.

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Thyroid cancer is the most common endocrine malignancy in dogs. Dogs and humans are similar in the spontaneous development of thyroid cancer and metastasis to lungs; however, thyroid cancer has a higher incidence of metastasis in dogs. This study developed a preclinical nude mouse model of canine thyroid cancer using a canine thyroid adenocarcinoma cell line (CTAC) and measured the expression of important invasion and metastasis genes in spontaneous canine thyroid carcinomas and CTAC cells. CTAC cells were examined by electron microscopy. Short tandem repeat analysis was performed for both the
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Bhattacharyya, Neil. "A Population-Based Analysis of Survival Factors in Differentiated and Medullary Thyroid Carcinoma." Otolaryngology–Head and Neck Surgery 128, no. 1 (2003): 115–23. http://dx.doi.org/10.1067/mhn.2003.2.

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OBJECTIVE: The study purpose was to determine survival and prognostic factors for differentiated thyroid carcinoma (DTC). METHODS: Cases of DTC were extracted from the Surveillance, Epidemiology and End Results database from 1988 through 1998. Kaplan-Meier survival analysis was conducted for papillary, follicular, and medullary histologies. Cox proportional hazard analysis was used to examine the influence of age, gender, tumor size, local extension, and cervical node involvement on overall survival. RESULTS: A total of 18,118 cases were identified, including 15,820 (87.3%) papillary carcinoma
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Moon, Shinje, Young Shin Song, Kyong Yeun Jung, et al. "The Initial Risk Stratification System for Differentiated Thyroid Cancer: Key Updates in the 2024 Korean Thyroid Association Guideline." Endocrinology and Metabolism 40, no. 3 (2025): 357–84. https://doi.org/10.3803/enm.2025.2465.

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In 2024, the Korean Thyroid Association (KTA) introduced a revised Risk Stratification System (K-RSS) for differentiated thyroid cancer, building upon the modified RSS (M-RSS) proposed by the American Thyroid Association in 2015. The K-RSS emphasizes the cumulative impact of coexisting clinical and pathological features, acknowledging that multiple intermediate-risk factors collectively indicate a higher recurrence risk. Histologic classification follows the 2022 World Health Organization classification, consolidating encapsulated follicular-patterned thyroid carcinomas, including invasive enc
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36

Slim, Ihsen, Aida Mhiri, Imène Meddeb, Aida Goucha, Saïd Gritli, and Mohamed Faouzi Ben Slimene. "Malar Bone Metastasis Revealing a Papillary Thyroid Carcinoma." Case Reports in Otolaryngology 2012 (2012): 1–4. http://dx.doi.org/10.1155/2012/795686.

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Papillary thyroid carcinoma is the most common form of differentiated thyroid carcinoma. It is generally confined to the neck with or without spread to regional lymph nodes. Metastatic thyroid carcinomas are uncommon and mainly include lung and bone. Metastases involving oral and maxillofacial region are extremely rare. We described a case of malar metastasis revealing a follicular variant of papillary thyroid carcinoma, presenting with pain and swelling of the left cheek in a 67-years-old female patient with an unspecified histological left lobo-isthmectomy medical history. To our knowledge,
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37

Hidangmayum, Abena, Michelle Mathias, Kishan Prasad H.L., Sajitha K., and Divya Joshi. "Synchronous follicular carcinoma and non-invasive follicular thyroid neoplasm with papillary like nuclear features in thyroid-A case report." Biomedicine 42, no. 1 (2022): 195–98. http://dx.doi.org/10.51248/.v42i1.584.

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Follicular carcinoma of the thyroid accounts for 5-15% of all the primary cancers of thyroid. Follicular carcinoma clinically manifests as a painless neck mass and rarely presents with metastatic bony lesion, the most common site being the spine. Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) constitute 10-20% of all thyroid cancers. The histopathological diagnosis of thyroid follicular carcinoma mandates demonstration of either capsular/vascular invasion. Differentiating between follicular carcinoma and NIFTP is challenging based on histology. Hence exte
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38

Zivaljevic, Vladan, Ivan Paunovic, Aleksandar Diklic, et al. "Classification, gradation, prognostic factors and risk factors for thyroid carcinoma." Acta chirurgica Iugoslavica 50, no. 3 (2003): 56–60. http://dx.doi.org/10.2298/aci0303056z.

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Thyroid carcinomas arise from follicular cells (papillary, follicular, Hurthle, anaplastic), parafollicular cells (medullary) and stroma (lymphoma, sarcoma?). Gradation and prognostic factors are different for every one of histological type. Most patients with papillary and follicular thyroid cancer have an excellent prognosis. At the other extreme is anaplastic thyroid cancer whose usual mean survival can be measured in months. Exposure to external radiation and living in endemic goiter area increase the frequency of thyroid cancer. Medullary thyroid carcinoma is often familial and may occur
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39

Elsheikh, Tarik M. "Histopathology of Encapsulated Follicular-Patterned Thyroid Tumors." AJSP: Reviews and Reports 24, no. 2 (2019): 41–52. http://dx.doi.org/10.1097/pcr.0000000000000298.

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Abstract Encapsulated follicular-patterned thyroid tumors remain diagnostically challenging for pathologists, including experts. The differential diagnosis typically includes hyperplastic/adenomatous nodule, follicular adenoma, follicular thyroid carcinoma, and follicular variant of papillary thyroid carcinoma (FVPTC). Noninvasive follicular thyroid neoplasm with papillary-like features is a new terminology that was recently proposed for a subset of noninvasive FVPTC that has a highly favorable outcome and can be treated in a conservative manner. This is in contrast to invasive-encapsulated FV
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40

Suster, Saul. "Thyroid Tumors With a Follicular Growth Pattern: Problems in Differential Diagnosis." Archives of Pathology & Laboratory Medicine 130, no. 7 (2006): 984–88. http://dx.doi.org/10.5858/2006-130-984-ttwafg.

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Abstract Tumors of the thyroid characterized by a follicular growth pattern constitute the most common type of lesion of this organ encountered by pathologists. The vast majority of such lesions do not pose difficulties for histopathologic interpretation. A subset of these tumors, however, can represent a serious challenge for diagnosis. Thyroid tumors with a follicular growth pattern include a broad range of lesions that range from benign, hyperplastic nodules to follicular adenomas to follicular carcinomas. In addition, other types of tumors belonging in separate diagnostic categories can al
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41

Tavares, Catarina, Miguel Melo, José Manuel Cameselle-Teijeiro, Paula Soares, and Manuel Sobrinho-Simões. "ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome." European Journal of Endocrinology 174, no. 4 (2016): R117—R126. http://dx.doi.org/10.1530/eje-15-0605.

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Genetic predictors of outcome are reviewed in the context of a disease – cancer – that can be (too) simplistically described as a ‘successful, invasive clone of our own tissues’. Context has many faces that determine a thyroid cancer patient's outcome beyond the influence of genetic markers. There is also plenty of evidence on the prognostic meaning of the interplay between genetics and context/microenvironment factors (encapsulation, degree of invasion, staging, etc.). This review addresses only genetic alterations detected by molecular methods in surgically resected specimens, thus ruling ou
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42

Mishunina, T. M., E. V. Kalinichenko, and N. D. Tronko. "DNA fragmentation rate in human thyroid tissue and carcinomas and its change under the influence of a-tocopherol and iodine ions in vitro." Problems of Endocrinology 55, no. 3 (2009): 40–44. http://dx.doi.org/10.14341/probl200955340-44.

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The rate of DNA fragmentation was studied in intact thyroid tissue and thyroid carcinoma tissue. The determination of low molecular-weight DNA concentrations and the electrophoretic analysis of DNA isolated from the thyroid tissues and tumors, followed by the calculation of the content of oligonucleosome fractions, indicated a drastic reduction in the DNA fragmentation rate in papillary carcinomas and no its significant changes in follicular carcinomas. In the intact thyroid tissue, α-tocopherol and potassium iodide at a concentration of 10-7 M inhibited the rate of stimulated DNA fragmentatio
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43

De Leo, Antonio, Daniela Serban, Thais Maloberti, et al. "Expanding the Spectrum of BRAF Non-V600E Mutations in Thyroid Nodules: Evidence-Based Data from a Tertiary Referral Centre." International Journal of Molecular Sciences 24, no. 4 (2023): 4057. http://dx.doi.org/10.3390/ijms24044057.

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The BRAF p.V600E mutation represents the most specific marker for papillary thyroid carcinoma and is potentially related to aggressive behavior and persistent disease. BRAF alterations other than the p.V600E are less common in thyroid carcinoma and represent an alternative mechanism of BRAF activation with unclear clinical significance. The study aims to describe the frequency and clinicopathologic characteristics of BRAF non-V600E mutations in a large cohort (1654 samples) of thyroid lesions characterized by next-generation sequencing. BRAF mutations have been found in 20.3% (337/1654) of thy
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44

Wali Ali, Thair. "The value of rapid semi-automated morphometric analysis system in predicting malignancy in thyroid follicular neoplasm." AL-QADISIYAH MEDICAL JOURNAL 13, no. 24 (2018): 131–37. http://dx.doi.org/10.28922/qmj.2017.13.24.131-137.

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Aims: To constuct and evaluate a rapid semiautomated system in discriminating malignant from benign follicular thyroid neoplasms. Methods: Sixty formalin fixed paraffin embeded blocks of follicular thyroidneoplasms were retreived and slides were prepared and H and E stained. A morphometric system was constructed to be as rapid as possible and was tested.Results: No signficant difference was found in ratio of largest nuclear to smallest nuclear diameter between follicualr adenoma and follicualr carcinoma groups.Conclusion: Rapid semiautomated morphometric analysis is of no help in predicting ma
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45

De Crea, Carmela, Marco Raffaelli, Luca Sessa, et al. "Actual Incidence and Clinical Behaviour of Follicular Thyroid Carcinoma: An Institutional Experience." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/952095.

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Follicular thyroid carcinoma classically accounts for 10–32% of thyroid malignancies. We determined the incidence and the behaviour of follicular thyroid carcinoma in an endemic goitre area. A comparative analysis between minimally invasive and widely invasive follicular thyroid carcinoma was performed. The medical records of all patients who underwent thyroidectomy from October 1998 to April 2012 for thyroid malignancies were reviewed. Those who had a histological diagnosis of follicular carcinoma were included. Among 5203 patients, 130 (2.5%) were included. Distant metastases at presentation
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46

Havelka, Marija, Svetislav Tatic, Ivan Paunovic, et al. "Pathohistologic and immunohistochemical features of thyroid carcinoma." Acta chirurgica Iugoslavica 50, no. 3 (2003): 61–65. http://dx.doi.org/10.2298/aci0303061h.

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Numerous pathohistologic criteria, difficultes and pitfalls in the process of diagnosing of thyroid carcinoma are discussed. Benign hyperplastic papillae may be present in colloidal cystic goiter and hyperplastic goiter. These structures are lined by cells with normochromatic nuclei and do not disturb the thyroid tissue architecture. Papillae in papillary thyroid carcinoma have cells with ground-glass, hypochromatic nuclei. Follicles inspissated in capsula of follicular or even colloidal adenoma may be evaluated as capsular invasion - diagnostic feature of follicular carcinoma. Undifferentiate
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47

Rastogi, Nupur. "Follicular carcinoma of thyroid presenting as widespread metastases." Asian Pacific Journal of Health Sciences 5, no. 3 (2018): 193–96. http://dx.doi.org/10.21276/apjhs.2018.5.3.26.

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48

Zoric, Goran, Marina Nikolic-Djurovic, Ivan Paunovic, et al. "Analysis of malignancy predictors for follicular thyroid tumors." Vojnosanitetski pregled 77, no. 3 (2020): 282–88. http://dx.doi.org/10.2298/vsp180314079z.

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Background/Aim. Establishing a preoperative diagnosis of thyroid follicular tumors is difficult due to the fact that the cell morphology of adenomas and carcinomas are similar and that capsular and vascular invasion cannot be determined by cytology. We analyzed predictive factors of follicular carcinoma in order to enable a surgeon to indicate operative treatment and to perform an adequate operation for each patient with a follicular neoplasm. Methods. In this retrospective study, we analyzed medical records of all patients with follicular thyroid tumors operated at an endocrine surgery unit o
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49

Chiba, Tomohiro. "Molecular Pathology of Thyroid Tumors: Essential Points to Comprehend Regarding the Latest WHO Classification." Biomedicines 12, no. 4 (2024): 712. http://dx.doi.org/10.3390/biomedicines12040712.

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In 2022, the new WHO Classification of Endocrine and Neuroendocrine Tumors, Fifth Edition (beta version) (WHO 5th), was published. Large-scale genomic analyses such as The Cancer Genome Atlas (TCGA) have revealed the importance of understanding the molecular genetics of thyroid tumors. Consequently, the WHO 5th was fundamentally revised, resulting in a systematic classification based on the cell of origin of tumors and their clinical risk. This paper outlines the following critical points of the WHO 5th. 1. Genetic mutations in follicular cell-derived neoplasms (FDNs) highlight the role of mut
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Majumder, Swapna, S. M. Asafudullah, Khadiza Khanom, et al. "Significance of P63 Expression in Papillary and Follicular Thyroid Carcinoma." TAJ: Journal of Teachers Association 36, no. 2 (2023): 121–28. http://dx.doi.org/10.3329/taj.v36i2.72235.

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Background: Papillary thyroid carcinoma (PTC) is the most frequent histologic type of all thyroid malignancies followed by follicular thyroid carcinoma (FC). Follicular variant of papillary thyroid carcinoma (FVPTC) is the second most common variant of PTC. A diagnostic dilemma may arise, when histologically the distinctive nuclear features are either not well developed or present focally within an encapsulated thyroid lesion. A panel of immunomarkers has been tested to overcome the limitation of histopathology. P63 is commonly used immunomarkers among them. Objectives: The aim of the present
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