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Rozprawy doktorskie na temat „Fracture healing”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Sandberg, Olof. "Metaphyseal Fracture Healing." Doctoral thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-126148.

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Most of what is known about fracture healing comes from studies of shaft fractures in long bones. In contrast, patients more often have fractures closer to the ends (metaphyses). Here most bone tissue has a spongy, cancellous structure different from the compact bone of the shaft. There is an increasing awareness that metaphyseal fractures heal differently. However, the more easily studied shaft healing has usually been considered as good enough representative for fracture healing in general. My work shows that the biology of metaphyseal healing is more different from shaft healing than was pr

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2

Hardy, John R. W. "Tibial diaphyseal fracture healing." Thesis, University of Leicester, 1996. http://hdl.handle.net/2381/34096.

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3

Gill, Peter John. "Ultrasonic assessment of fracture healing." Thesis, Queen's University Belfast, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356863.

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4

Richardson, James Bruce. "The mechanics of fracture healing." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.290866.

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The mechanics applied to healing fractures vary widely. At one extreme rigid internal fixation is advocated, while at the other early mobilisation is recommended using external splints. Kuhn's method of paradigm orientated research was used to define the historical context of current assumptions regarding fracture healing. Conflict between the various schools of thought is the main evidence for failure of these assumptions and the need to evolve a new perspective on fracture healing. A paradigm is presented which proposes healing by external callus as an early stage and 'primary healing' as th

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5

Wade, Roger. "Defining fracture union." Thesis, Keele University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249450.

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6

Shroff, Malav. "Effect of age on fracture healing." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393369.

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7

Gheduzzi, Sabina. "Fracture healing assessment by quantitative ultrasound measurements." Thesis, University of Bath, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.341701.

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8

Dawson, Sarah P. "Digital X-ray analysis for monitoring fracture healing." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4285.

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X-ray based evaluation of different stages of fracture healing is a well established clinical standard. However, several studies have shown plain radiography alone to be an unreliable method to assess healing. The advent of digital X-ray systems provides the potential to perform quantitative analysis on X-ray images without disrupting normal clinical practice. Two aspects were explored in this study. The first was the measurement of mechanical fracture stiffness under four point bending and axial loading. The second was the inclusion of an Aluminium step wedge to provide Aluminium-equivalent t

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9

Li, Jiang, and 李江. "Bone fracture healing in laminopathy-based premature aging." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45142233.

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10

Shirley, D. S. L. "Osteoblastic cells are systemically recruited during fracture healing." Thesis, Queen's University Belfast, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401767.

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11

Laycock, D. C. "Vibration analysis of fracture healing in long bones." Thesis, University of Salford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293031.

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12

Savaridas, Terence. "The effects of bisphosphonate on direct fracture healing." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/25158.

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Fractures repair by two distinct mechanism; indirect fracture healing via an endochondral stage and direct fracture healing with primary bone formation via osteonal remodelling units ('cutting cones'). Bisphosphonates are recommended by national clinical guidelines to reduce the risk of osteoporotic fractures. Despite bisphosphonate therapy, osteoporotic fractures continue to occur. A proportion of these fractures require rigid fixation, whereby bone repairs by direct fracture healing. The effects of bisphosphonate therapy on direct fracture healing have not been previously reported. With indi

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13

Yew, Alvin Garwai. "The equilibrium geometry theory for bone fracture healing." College Park, Md. : University of Maryland, 2008. http://hdl.handle.net/1903/8308.

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Thesis (M.S.) -- University of Maryland, College Park, 2008.<br>Thesis research directed by: Dept. of Mechanical Engineering. Title from t.p. of PDF. Includes bibliographical references. Published by UMI Dissertation Services, Ann Arbor, Mich. Also available in paper.

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14

Watkins, P. E. "A study of mechanical influences on fracture healing, and on fracture non-union." Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376622.

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15

Reed, Anita A. C. "The biological activity of fracture non-unions." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249459.

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16

Vijayakumar, Vinod. "Stress/strain environments in healing human tibial fractures." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275202.

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17

Christersson, Albert. "Fractures of the distal radius : Factors related to radiographic evaluation, conservative treatment and fracture healing." Doctoral thesis, Uppsala universitet, Ortopedi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-312931.

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Distal radius fractures (DRFs) are one of the most common injuries encountered in orthopaedic practise. Such fractures are most often treated conservatively, but surgical treatment has become increasingly common. This trend is not entirely scientifically based The aims of this thesis were threefold: to increase measurement precision in dorsal angulation (DA) on radiographs and computer tomographies (CTs); to assess the results after shortened plaster cast fixation time in reduced DRFs; and to evaluate the feasibility and safety of applying Augment® (rhPDGF-BB/β-TCP) in DRFs. In Paper I and App

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18

Varga-Vass, Anna. "Large-scale dynamic hydrofracturing, healing and fracture network characterization." Thesis, University of Glasgow, 2015. http://theses.gla.ac.uk/6846/.

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Permeability of a rock is a dynamic property that varies spatially and temporally. Fractures provide the most efficient channels for fluid flow and thus directly contribute to the permeability of the system. Fractures usually form as a result of a combination of tectonic stresses, gravity (i.e. lithostatic pressure) and fluid pressures. High pressure gradients alone can cause fracturing, the process which is termed as hydrofracturing that can determine caprock (seal) stability or reservoir integrity. Fluids also transport mass and heat, and are responsible for the formation of veins by precipi

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19

Hanratty, B. M. "The Effect of TP508 on High Energy Fracture Healing." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501272.

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20

Manitzky, Louise J. "Mathematical modelling of intramembranous bone formation during fracture healing." Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/78983/1/Louise_Manitzky_Thesis.pdf.

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During fracture healing, many complex and cryptic interactions occur between cells and bio-chemical molecules to bring about repair of damaged bone. In this thesis two mathematical models were developed, concerning the cellular differentiation of osteoblasts (bone forming cells) and the mineralisation of new bone tissue, allowing new insights into these processes. These models were mathematically analysed and simulated numerically, yielding results consistent with experimental data and highlighting the underlying pattern formation structure in these aspects of fracture healing.

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21

Lee, Geoffrey. "Targeting alarmins to accelerate healing." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:2ea58ae6-9d79-461a-a1d9-dff95c79794e.

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Promoting tissue repair in adults represents a major unmet medical need. Tissue regeneration relies on the activation of quiescent endogenous stem cells and whilst considerable progress has been made, novel therapies based on stem cells have thus far failed to translate to routine clinical practice. Much attention has focussed on administrating exogenous stem cells expanded or altered in vitro. However, this approach faces several major limitations, including poor engraftment, high cost and importantly, the necessity for immunosuppression for allogenic cells. An alternative strategy that overc

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22

Fallon, Jessica Anne. "Crack healing as a function of pOH- and fracture morphology." Texas A&M University, 2004. http://hdl.handle.net/1969.1/1369.

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Crack healing in quartz has been investigated by optical microscopy and interferometry of rhombohedral ( 1 1 10 ) cracks in polished Brazilian quartz prisms that were annealed hydrothermally at temperatures of 250°C and 400°C for 2.4 to 240 hours, fluid pressure Pf = Pc = 41 MPa, and varying pOH- (from 5.4 to 1.2 at 250°C for fluids consisting of distilled water and NaOH solutions with molalities up to 1). Crack morphologies before and after annealing were recorded for each sample in plane light digital images. Crack apertures were determined from interference fringes recorded using transmitte

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23

Murray, Alastair W. "Fracture healing in osteopenic bone and the influence of simvastatin." Thesis, University of Edinburgh, 2007. http://hdl.handle.net/1842/29286.

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In part one of the study 20, 3-month-old female, Wistar rats underwent ovariectomy (Ovx) while a further 20 had a sham procedure to act as controls. Seven weeks later a transverse fracture was created in the proximal tibia of each animal by three-point bending with the resulting fractures supported by an intramedullary wire. Half of the animals in each group were euthanased at two weeks and the remainder at four weeks post fracture with tibiae removed post mortem. All tibiae were then x-rayed. The mechanical properties of half of the healing fractures were ascertained by four-point bending to

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24

Niemeyer, Frank [Verfasser]. "Simulation of fracture healing : applied to distraction osteogenesis / Frank Niemeyer." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1043262245/34.

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25

Nakagawa, Yasuaki. "Calcium-Dependent Neutral Proteinase(Calpain)in Fracture Healing of Rats." Kyoto University, 1994. http://hdl.handle.net/2433/168857.

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本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第5555号<br>医博第1525号<br>新制||医||577(附属図書館)<br>UT51-94-C13<br>京都大学大学院医学研究科外科系専攻<br>(主査)教授畑中正一, 教授岡正典, 教授山室隆夫<br>学位規則第4条第1項該当

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26

Kaluarachchi, Thambilipitiyage Kusumsiri Priyantha Kumara. "Impact of collagen type X deficiency on bone fracture healing." Thesis, Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23501807.

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27

Nyquist, Fredrik. "The influence of alcohol on bone metabolism and fracture healing." Lund : Lund University, Dept. of Orthopaedics, Malmö University Hospital, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39792795.html.

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28

Eveleigh, Rebecca. "A biomechanical evaluation of intramedullary nails during simulated fracture healing." Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362194.

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29

Schütte, Andrea. "Autoantibodies against growth factors and their receptors in fracture healing." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17656.

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Die Knochenregeneration während der Frakturheilung beinhaltet das Zusammenspiel von Wachstumsfaktoren. In einigen Patienten kommt es zu einer verzögerten oder unvollständigen Heilung. Die Gründe hierfür sind bisher nicht komplett verstanden. Neutralisierende Autoantikörper (aAB) gegen Wachstumsfaktoren oder deren Rezeptoren könnten den Heilungsprozess verzögern und potentiell beeinträchtigen In dieser Arbeit wurden 265 Frakturpatienten analysiert. Autoantikörper gegen IGF1 Rezeptor, Insulin Rezeptor, BMP7, BMP2, IGF1 und (Pro)Insulin wurden in den Seren dieser Frakturpatienten gemessen. In

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30

Schlundt, Claudia. "Impact of the adaptive immune system in bone fracture healing." Doctoral thesis, Humboldt-Universität zu Berlin, 2017. http://dx.doi.org/10.18452/18195.

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Knochengewebe besitzt die einzigartige Fähigkeit sich nach einem Bruch komplett zu regenerieren. Dennoch zeigen 10-15% der Patienten einen gestörten Heilungsverlauf. Das Immunsystem spielt eine entscheidende Rolle in der Frakturheilung. Im Rahmen der hier präsentierten Doktorarbeit wurde der Einfluss der CD4+ regulatorischen T-Zellen (Treg) auf die Knochenheilung untersucht. In einem Maus-Osteotomie-Modell wurde die zeitliche und räumliche Verteilung ausgewählter Immun- und Knochenzellen im osteotomierten Knochen untersucht. Dabei konnte gezeigt werden, dass Immunzellen im gesamten Heilungsver

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31

Chehade, Mellick Joseph. "Bone resonance analysis, histomorphometry and the mechanics of fracture healing." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phc515.pdf.

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32

Aird, J. "Human Immunodeficiency Virus and open fractures : is wound or fracture healing affected in surgically stabilised open fractures? : a prospective study." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1343913/.

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Background: 33 million people worldwide are infected with HIV, a complex disease that affects many of the processes involved in wound and fracture healing. There is little evidence available to guide acute management of open fractures in these patients and fears of acute and delayed sepsis often inhibit the use of surgical fixation, which may be the most effective way of achieving union. This study addresses the hypothesis that the presence of either HIV or advanced HIV (CD4 count <=350) leads to an increased risk of complications in patients with open fractures treated with surgical stabiliza

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33

Li, Jian. "Spontaneous correction of fracture deformity : a study in the rat /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-119-9/.

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34

Oess, Ninja P. "Strain measurements using magnetoelastic sensing for wireless bone fracture healing assessment /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17550.

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35

Pietsch, Martin [Verfasser]. "Modelling the fracture healing process with interface capturing techniques / Martin Pietsch." Ulm : Universität Ulm, 2019. http://d-nb.info/1175527068/34.

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36

Pfeiffenberger, Moritz [Verfasser]. "Mimicking the initial phase of fracture healing in vitro / Moritz Pfeiffenberger." Berlin : Freie Universität Berlin, 2021. http://d-nb.info/123689748X/34.

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37

Mahmud, Fares A. "The electromechanical properties of bone." Thesis, Staffordshire University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254325.

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38

Mawhinney, Ian Nicholas. "Bone and ultrasound." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335942.

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39

Fourie, Jeanette Ann. "Stimulation of bone healing in new fractures of the tibial shaft using interferential currents." Master's thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/27041.

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The aims . of this research were twofold, firstly to find out if interferential currents could reduce the healing time for fractures of the tibia and thereby prevent nonunion and secondly to develop a model which could predict nonunion, given the subject characteristics such as race, mechanism of injury, severity of fracture etc. Subjects, males only between the ages of 12 and 86, who had sustained fractures of the tibiae were entered into this double blind clinical trial on admission to the orthopaedic wards at Groote Schuur Hospital (between January 1989 and October 1991). According to stric

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40

Nemchand, Jaya Luxshmi. "Smart implant : the biomechanical testing of instrumented intramedullary nails during simulated callus healing using telemetry for fracture healing monitoring." Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/11592.

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The purpose of this study is to investigate the effect of loading during long bone fracture healing in-vitro and in-vivo. Fracture healing has until now only been monitored using radiographs and ultrasound. An intramedullary nail instrumented with strain gauges has the potential to monitor loading in-vivo during bone fracture healing. Strain has been previously monitored over time though external fixation devices however there has been no published data about monitoring through a nail. The load carried by a telemetric intramedullary nail during simulated fracture healing is monitored in-vitro

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41

Löffler, Julia [Verfasser]. "Impact of the local metabolic milieu on bone fracture healing / Julia Löffler." Berlin : Freie Universität Berlin, 2019. http://d-nb.info/1192304195/34.

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42

Weber, Agnes Johanna [Verfasser]. "Fracture healing and glucocorticoids in HSD2 transgenic mouse model / Agnes Johanna Weber." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2012. http://d-nb.info/1026694914/34.

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43

Bunn, Robert Jonathan. "Pro-inflammatory cytokines in delayed fracture healing induced by local muscle crush." Thesis, Queen's University Belfast, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397898.

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44

Mounts, Alexander Kim. "Effects of a BMP antagonist on fracture healing in a mouse model." Thesis, Boston University, 2013. https://hdl.handle.net/2144/12165.

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Thesis (M.A.)--Boston University<br>Introduction: Fracture healing is a complex process that is responsible for forming a fracture callus to stabilize the site of injury while producing new bone. Delayed fracture healing or the development of non-union as a result of failed fracture healing is a major clinical concern effecting ~10% of all treated fractures. Recent studies have shown that RAP-661, an antagonist of Bone Morphogenetic Proteins (BMP) 2 and BMP-4 binding to its receptor BMPR-1A has shown anabolic efficacy in treating bone loss associated with osteoporosis. The purpose of this stud

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45

Spencer, Robert F. "The effect of head injury on fracture healing : clinical and experimental studies." Thesis, University of Edinburgh, 1990. http://hdl.handle.net/1842/19310.

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46

Scarpa, Edoardo. "Polymeric nanoparticles loaded with a Wnt agonist for enhancing bone fracture healing." Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/408720/.

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In the UK, over 2 million people suffer a bone fracture every year. 10% of bone fractures will not heal adequately and require surgical intervention and, as yet, there is no approved systemic drug that is effective in promoting and accelerating fracture healing. Wnt signalling activation is a promising therapeutic target to address this paucity of treatments. Wnt is a molecular pathway that controls bone homeostasis and repair. However, its activation can have both positive and negative effects on bone cell function depending on the timing and site of delivery. Polymersomes (PMs) are polymeric

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47

Shen, Kaitlin. "The Role of Activated Protein C in Bone, Arthritis, and Fracture Healing." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14376.

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Activated protein C (APC) is a cytoprotective anticoagulant that stimulates cellular proliferation, suppresses inflammation, and enhances wound healing. These properties of APC are primarily modulated through its receptors, endothelial protein C receptor (EPCR) and protease-activated receptors (PAR)1/2, and subsequent activation of downstream proteins including ERK1/2, Akt, and p38. In this study, APC was investigated for its potential application in bone repair and arthritic bone conditions, including rheumatoid arthritis (RA) and osteoarthritis (OA), through its actions on osteoblasts. APC i

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48

Salem, Khaled Hamed [Verfasser]. "Analysis of delayed fracture healing following unreamed tibial nailing / Khaled Hamed Salem." Ulm : Universität Ulm. Medizinische Fakultät, 2004. http://d-nb.info/1015471188/34.

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49

Brugo, Tommaso Maria <1985&gt. "Fracture Toughening and Self-Healing of Composite Laminates by Nanofibrous Mats Interleaving." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amsdottorato.unibo.it/7950/1/Tommaso%20Maria%20Brugo%20PhD%20Thesis.pdf.

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Composite laminates present important advantages compared to conventional monolithic materials, mainly because for equal stiffness and strength they have a weight up to four times lower. However, due to their ply-by-ply nature, they are susceptible to delamination, whose propagation can bring the structure to a rapid catastrophic failure. In this thesis, in order to increase the service life of composite materials, two different approaches were explored: increase the intrinsic resistance of the material or confer to them the capability of self-repair. The delamination has been hindered throug

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50

Watson, Hilary Joy. "Longitudinal study of recovery following diaphyseal fracture of the tibia or femur." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/19399.

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