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Artykuły w czasopismach na temat „Fracture healing”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Engelhardt, Lucas, Frank Niemeyer, Patrik Christen, et al. "Simulating Metaphyseal Fracture Healing in the Distal Radius." Biomechanics 1, no. 1 (2021): 29–42. http://dx.doi.org/10.3390/biomechanics1010003.

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Simulating diaphyseal fracture healing via numerical models has been investigated for a long time. It is apparent from in vivo studies that metaphyseal fracture healing should follow similar biomechanical rules although the speed and healing pattern might differ. To investigate this hypothesis, a pre-existing, well-established diaphyseal fracture healing model was extended to study metaphyseal bone healing. Clinical data of distal radius fractures were compared to corresponding geometrically patient-specific fracture healing simulations. The numerical model, was able to predict a realistic fra

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Gajdobranski, Djordje, and Dragana Zivkovic. "Impaired fracture healing." Medical review 56, no. 3-4 (2003): 146–51. http://dx.doi.org/10.2298/mpns0304146g.

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Introduction Bone fracture healing is a complex cascade of events at cellular and biochemical levels, that ends by complete structural and functional restoration of a damaged bone. Impaired healing develops in 5-10% of all fractures, and manifests as delayed union or non-union. This paper deals with the problem of impaired healing as well as with methods of fracture healing enhancement. Causes of impaired fracture healing There are many factors causing impaired fracture healing (inadequate vascularization, mechanical causes, infection, etc.), and it is very important to recognize the principle

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Wollstein, Ronit, Arie Trouw, Lois Carlson, Ilene Staff, Daniel J. Mastella, and Duffield Ashmead. "The Effect of Age on Fracture Healing Time in Metacarpal Fractures." HAND 15, no. 4 (2018): 542–46. http://dx.doi.org/10.1177/1558944718813730.

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Background: Older patients are treated for fracture with increasing frequency. Although studies on animals suggest that older mice and rats heal fractures more slowly, the clinical implications remain unclear. A better understanding of differences in healing with age can help customize fracture treatment. Our purpose was to retrospectively evaluate metacarpal fractures for healing time looking specifically at age-related differences. Methods: A retrospective review of patients treated for metacarpal fractures was conducted. Patients with incomplete charts or inadequate follow-up were excluded.

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Omar, Raffal A., and S. I. Saleh. "Study of low power Laser effect on the healing of tibial fracture treated by intramedullary pin in rabbits." Iraqi Journal of Veterinary Medicine 27, no. 1 (2003): 99–108. http://dx.doi.org/10.30539/ijvm.v27i1.1100.

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The effect of low power laser (LPL) on the healing of distal third of tibial fractures has been studied radiologically.  Fractures induced in twenty-five local breed rabbits, immobilization achieved by using Steinman intramedullary pins, which was not removed during the period of study for 7 weeks.  Irradiation with LPL was made by direct contact between the source and the site of fracture directly after the operation and then daily for fifteen days.  Each fracture was studied radiologically after the first day from the operation until complete healing occurs.  This stu

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Raschke, Michael, Michael Højby Rasmussen, Shunmugam Govender, David Segal, Mette Suntum, and Jens Sandahl Christiansen. "Effects of growth hormone in patients with tibial fracture: a randomised, double-blind, placebo-controlled clinical trial." European Journal of Endocrinology 156, no. 3 (2007): 341–51. http://dx.doi.org/10.1530/eje-06-0598.

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Objective: Investigate whether intervention with GH after tibial fracture enhances fracture healing. Design: Randomised, double-blind, placebo-controlled study in 406 patients (93 women, 313 men, age: 18–64 years) with tibial fracture. Methods: Patients were stratified by tibial fracture (open or closed) and allocated to placebo or GH treatment (15, 30 or 60 μg/kg daily, until clinically assessed healing or until 16 weeks post-surgery). Primary outcome was time from surgery until fracture healing and assessment of healing was done centrally and observer blinded. Patients reported for evaluatio

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Johnson, Ann L., M. Chambers, C. W. Smith, et al. "Qualitative and Quantitative Scintigraphic Imaging to Predict Fracture Healing." Veterinary and Comparative Orthopaedics and Traumatology 12, no. 03 (1999): 142–50. http://dx.doi.org/10.1055/s-0038-1632480.

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SummaryPurpose: Evaluate the value of 24- hour postoperative quantitative bone scintigraphy to identify devascularized fragments and predict delayed fracture bridging in canine clinical patients; to determine the effect of fracture type, fixation type, age, sex, and weight on fracture bridging and the quantitative scintigraphic ratios; and to evaluate the relationship between qualitative scintigraphic assessment and quantitative scintigraphic ratios. Methods: Forty-two adult dogs, with diaphyseal long bone fractures treated with minimally invasive biological or invasive surgical techniques, we

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Wank, Isabel, Tanja Niedermair, Daniel Kronenberg, et al. "Influence of the Peripheral Nervous System on Murine Osteoporotic Fracture Healing and Fracture-Induced Hyperalgesia." International Journal of Molecular Sciences 24, no. 1 (2022): 510. http://dx.doi.org/10.3390/ijms24010510.

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Osteoporotic fractures are often linked to persisting chronic pain and poor healing outcomes. Substance P (SP), α-calcitonin gene-related peptide (α-CGRP) and sympathetic neurotransmitters are involved in bone remodeling after trauma and nociceptive processes, e.g., fracture-induced hyperalgesia. We aimed to link sensory and sympathetic signaling to fracture healing and fracture-induced hyperalgesia under osteoporotic conditions. Externally stabilized femoral fractures were set 28 days after OVX in wild type (WT), α-CGRP- deficient (α-CGRP −/−), SP-deficient (Tac1−/−) and sympathectomized (SYX

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Bottai, Vanna, Gabriele Gariffo, Edoardo Ipponi, Roberta Cifali, Nicola Mondanelli, and Stefano Giannotti. "Use of teriparatide in preventing delayed bone healing in complex biosseous leg fracture: a case report." International Journal of Bone Fragility 1, no. 1 (2021): 14–16. http://dx.doi.org/10.57582/ijbf.210101.014.

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Fracture nonunion is one of the greatest challenges for orthopedic surgeons. We present the case of a young man with a complex open biosseous fracture of the leg who underwent surgery and early systemic pharmacological treatment with teriparatide. Teriparatide is widely used in the treatment of osteoporosis as its anabolic effects promote the deposition of new bone tissue. Associated tibia and fibula fractures have relatively high rates of nonunion and poor long-term outcomes. In this particular case, the fracture had further negative prognostic factors, such as exposure. Two months after the

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9

Smith, Robert G. "Fracture Healing." Journal of the American Podiatric Medical Association 105, no. 2 (2015): 160–72. http://dx.doi.org/10.7547/0003-0538-105.2.160.

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Background Recognizing the existence of adverse drug effects of frequently prescribed drugs can empower a clinician with knowledge to avoid dangerous adverse effects that may result in hazardous, negative patient outcomes on either fracture healing or bone health. Pharmacovigilance reports have described the influence of medications, allowing for bone health to be quite unpredictable. Methods First, mechanisms found in the medical literature of potential drug adverse effects regarding fracture healing are presented. Second, the 100 most frequently prescribed medications in 2010 are reviewed re

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Raghavan, Pooja, and Elena Christofides. "Role of Teriparatide in Accelerating Metatarsal Stress Fracture Healing: A Case Series and Review of Literature." Clinical Medicine Insights: Endocrinology and Diabetes 5 (January 2012): CMED.S9663. http://dx.doi.org/10.4137/cmed.s9663.

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Bone fractures are one of the leading causes of emergency room visits worldwide, with approximately 8 million bony fractures occurring annually in the US alone. Although the majority of fractures do not cause significant long-term morbidity and mortality, approximately 10% of these fractures result in impaired fracture healing, drastically affecting quality of life in affected patients. By increasing bone formation, teriparatide, an anabolic agent used in the treatment of postmenopausal osteoporosis, has shown promise in accelerating the rate of fracture healing. We present two patients with i

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Warmerdam, Elke, Marcel Orth, Tim Pohlemann, and Bergita Ganse. "Gait Analysis to Monitor Fracture Healing of the Lower Leg." Bioengineering 10, no. 2 (2023): 255. http://dx.doi.org/10.3390/bioengineering10020255.

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Fracture healing is typically monitored by infrequent radiographs. Radiographs come at the cost of radiation exposure and reflect fracture healing with a time lag due to delayed fracture mineralization following increases in stiffness. Since union problems frequently occur after fractures, better and timelier methods to monitor the healing process are required. In this review, we provide an overview of the changes in gait parameters following lower leg fractures to investigate whether gait analysis can be used to monitor fracture healing. Studies assessing gait after lower leg fractures that w

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ZHOU, JIANGJUN, RUI YI, MIN ZHAO, et al. "PERSONALIZED FINITE ELEMENT MODELING ANALYSIS OF FEMUR BONE HEALING AFTER INTRAMEDULLARY NAILING." Journal of Mechanics in Medicine and Biology 16, no. 05 (2016): 1650061. http://dx.doi.org/10.1142/s0219519416500615.

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Purpose: Based on rapid modeling 1 year after intramedullary nailing, personalized finite element modeling analysis was performed to predict whether the broken ends of fractured bones would break again after nail dislodgement. Methods: A total of 10 male volunteers with femur fractures who had undergone intramedullary nailing were selected 1 year after fixation and were divided into healing ([Formula: see text][Formula: see text]5) and non-healing ([Formula: see text][Formula: see text]5) groups based on X-ray analysis. We modeled each femoral fracture and performed finite element analyses aft

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13

Wang, Yufa, Aouod Agenor, Allison Clement, Adam Hopfgartner, Cari Whyne, and Diane Nam. "Probiotics: Can it modulate fracture healing?" PLOS ONE 18, no. 8 (2023): e0290738. http://dx.doi.org/10.1371/journal.pone.0290738.

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Objective Fractures remain a huge burden and their management adversely affects individuals’ function and productivity during the lengthy healing period. Gut microbiota exerts a systemic influence on diverse aspects of host physiology, including bone. The primary objective of this study was to evaluate if oral probiotic treatment before or after a fracture in a mouse model could increase cytokines and biomarkers essential for bone healing with subsequent improvement in the biomechanical properties of the healed callus. Methods Femoral osteotomy and intramedullary pinning were performed on C57B

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Jha, S. S., Amit B. Jain, Nilanj Dave, Alok Chaturvedi, and Sandesh Warudkar. "Teriparatide in fracture healing: Case series and review of literature." IP International Journal of Orthopaedic Rheumatology 7, no. 2 (2022): 93–100. http://dx.doi.org/10.18231/j.ijor.2021.021.

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Teriparatide (TPTD) (recombinant Parathyroid Hormone 1-34) is one of the pioneer osteo-anabolic agents approved for management of osteoporosis. Being an anabolic agent, it increases bone mineral density by inducing formation of new bone by the action on osteoblasts. As new bone formation is an important aspect of fracture healing as well, Teriparatide has long been a product of interest with respect to its effect on the process of fracture healing. Though fracture healing is not an approved indication for Teriparatide, there is quite a substantial amount of published data related to its effect

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Mick, Paul, and Christian Fischer. "Delayed Fracture Healing." Seminars in Musculoskeletal Radiology 26, no. 03 (2022): 329–37. http://dx.doi.org/10.1055/s-0041-1740380.

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AbstractPhysiologic bone healing involves numerous parameters, such as microstability, fracture morphology, or tissue perfusion, to name just a few. Slight imbalances or a severe impairment of even one of these factors may, as the figurative weakest link in the chain, crucially or completely inhibit the regenerative potential of a fractured bone. This review revisits the physiology and pathophysiology of fracture healing and provides an insight into predispositions, subtypes, diagnostic tools, and therapeutic principles involved with delayed fracture healing and nonunions. Depending on the pat

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TANG, Camelia Qian Ying, Si Min CHIOW, Sean Han Sheng LAI, and Dawn Sinn Yii CHIA. "The Effect of Hand Dominance, Age, Gender, Fracture Comminution and ASA Status on Time to Fracture Healing Following Surgical Fixation of Distal Radius Fractures." Journal of Hand Surgery (Asian-Pacific Volume) 27, no. 03 (2022): 459–65. http://dx.doi.org/10.1142/s2424835522500461.

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Background: There is recent renewed interest in the effect of hand dominance on distal radius fractures. Current studies focus on functional or patient-reported outcomes, with lack of studies pertaining to radiological outcomes. The primary aim of this study is to examine the effect of hand dominance on time to fracture healing following surgical fixation of distal radius fracture. We also looked at the effect of age, gender, fracture comminution and American Society of Anaesthesiologists (ASA) status on time to fracture healing. Methods: Patients who underwent distal radius fracture fixation

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Haffner-Luntzer, M., and A. Ignatius. "Animal models for studying metaphyseal bone fracture healing." European Cells and Materials 40 (October 29, 2020): 172–88. http://dx.doi.org/10.22203/ecm.v040a11.

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An estimated 2 million osteoporotic fractures occur annually in the US, resulting in a dramatic reduction in quality of life for affected patients and a high economic burden for society. Osteoporotic fractures are frequently located in metaphyseal bone regions. They are often associated with healing complications, because of the reduced healing capacity of the diseased bone tissue, the poor primary stability of the fracture fixation in the fragile bone, and the high frequency of comorbidities in these patients. Therefore, osteoporotic fractures require optimised treatment strategies to ensure

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Tulleners, Eric P. "Metacarpal and metatarsal fractures in dairy cattle: 33 cases (1979–1985)." Journal of the American Veterinary Medical Association 189, no. 4 (1986): 463–68. https://doi.org/10.2460/javma.1986.189.04.463.

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SUMMARY Metacarpal (22) and metatarsal (11) fractures in 33 dairy cattle were treated by application of short or full limb casts. Twelve fractures involved the distal physis (6 closed, 6 open) and 21 fractures were nonphyseal (17 closed, 4 open). All physeal fractures were noncomminuted and 11/12 were classified as Salter-Harris type II. Eleven (52%) of nonphyseal fractures were comminuted. Closed fractures were reduced and a cast was applied after manual restraint, sedation with xylazine (along with use of ropes), or general anesthesia. Open fractures were best treated with the cow under gene

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Inoue, Satoshi, Jiro Takito, and Masanori Nakamura. "Site-Specific Fracture Healing: Comparison between Diaphysis and Metaphysis in the Mouse Long Bone." International Journal of Molecular Sciences 22, no. 17 (2021): 9299. http://dx.doi.org/10.3390/ijms22179299.

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The process of fracture healing varies depending upon internal and external factors, such as the fracture site, mode of injury, and mechanical environment. This review focuses on site-specific fracture healing, particularly diaphyseal and metaphyseal healing in mouse long bones. Diaphyseal fractures heal by forming the periosteal and medullary callus, whereas metaphyseal fractures heal by forming the medullary callus. Bone healing in ovariectomized mice is accompanied by a decrease in the medullary callus formation both in the diaphysis and metaphysis. Administration of estrogen after fracture

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Gill, P. J., G. Kernohan, I. N. Mawhinney, R. A. B. Mollan, and R. McIlhagger. "Investigation of the Mechanical Properties of Bone Using Ultrasound." Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine 203, no. 1 (1989): 61–63. http://dx.doi.org/10.1243/pime_proc_1989_203_009_01.

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This paper examines the serial use of ultrasonic velocity measurement to monitor fracture healing. New Zealand White rabbit tibiae were fractured using a constant-energy technique and the ultrasonic velocity along the bone measured in animals sacrificed at 16 day intervals up to 96 days from fracture. In parallel with these measurements the mechanical performance of the healed tibiae were determined using a three-point bending test. Regression analysis failed to show a sufficiently good correlation between ultrasonic velocity measurements and the bending properties of healing fractures for the

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Agarwala, Sanjay, and Mayank Vijayvargiya. "Repurposing denosumab for recalcitrant bone healing." BMJ Case Reports 14, no. 2 (2021): e238460. http://dx.doi.org/10.1136/bcr-2020-238460.

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Fracture healing has four phases: haematoma formation, soft callus, hard callus and remodelling. Often, non-healing fractures have an arrest of one of these phases, which need resurgery. We have repurposed denosumab for impaired fracture healing cases to avoid surgical intervention. Here, we report a series of three cases of impaired fracture healing where denosumab was given 120 mg subcutaneous dosages for 3 months to enhance healing. All the three cases have shown complete bone union at a mean follow-up of 6.7 months (5–9 months) as assessed clinically and radiologically, and have observed n

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OSIPOV, Maksim D. "Consolidation of femoral neck fractures depending on fracture type." Medicine and Physical Education: Science and Practice, no. 11 (2021): 12–16. http://dx.doi.org/10.20310/2658-7688-2021-3-3(11)-12-16.

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We study the terms of the femoral neck fracture healing, depending on the type of fractures. Currently, the diagnosis of “hip fracture” occupies a significant place in the work of a traumatologist, since this fracture tends to increase the frequency of cases, especially among people over 60 years old. This problem has long been one of the most urgent in traumatology and orthopedics, includes many facets, among which there is a high risk of complications during the operation of these fractures among elderly and senile people, the growth of people at high risk of hip fracture due to osteoporotic

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Takebe, Hiroaki, Nazmus Shalehin, Akihiro Hosoya, Tsuyoshi Shimo, and Kazuharu Irie. "Sonic Hedgehog Regulates Bone Fracture Healing." International Journal of Molecular Sciences 21, no. 2 (2020): 677. http://dx.doi.org/10.3390/ijms21020677.

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Bone fracture healing involves the combination of intramembranous and endochondral ossification. It is known that Indian hedgehog (Ihh) promotes chondrogenesis during fracture healing. Meanwhile, Sonic hedgehog (Shh), which is involved in ontogeny, has been reported to be involved in fracture healing, but the details had not been clarified. In this study, we demonstrated that Shh participated in fracture healing. Six-week-old Sprague–Dawley rats and Gli-CreERT2; tdTomato mice were used in this study. The right rib bones of experimental animals were fractured. The localization of Shh and Gli1 d

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Durak, K., G. Sonmez, B. Sarisozen, S. Ozkan, M. Kaya та C. Ozturk. "Histological Assessment of the Effect of α-Tocopherol on Fracture Healing in Rabbits". Journal of International Medical Research 31, № 1 (2003): 26–30. http://dx.doi.org/10.1177/147323000303100104.

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To investigate the effect of α-tocopherol (vitamin E) on fracture healing in rabbits, two groups of 10 rabbits were either injected with α-tocopherol (treated) or untreated (controls). The right femurs of both groups were fractured, and the treated group were injected intramuscularly with 20 mg/kg α-tocopherol daily for 5 days starting on the day of fracture. After 21 days, histological sections of the fractured region were examined and scored. Fracture healing had progressed further in the α-tocopherol group than in the control group. A statistically significant difference between the histolo

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Clark, Daniel, Theodore Miclau, Mary Nakamura, and Ralph Marcucio. "AGE-RELATED CHANGES TO MACROPHAGES AFFECT FRACTURE HEALING." Innovation in Aging 3, Supplement_1 (2019): S83. http://dx.doi.org/10.1093/geroni/igz038.321.

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Abstract Fracture healing follows a strict temporal sequence characterized by an initial inflammatory phase. Perturbation of the inflammatory phase may be responsible for the poorer fracture healing outcomes in older adults. Herein, we examine age-related changes to the macrophage during fracture healing. Macrophages regulate inflammation through pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes. Anti-inflammatory activity is promoted via activation of triggering receptor expressed on myeloid cells 2 (TREM2). Tibia fractures were made in old (24 months) and young (3 months) mice. Imm

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Wallace, L. J., P. T. Redig, J. E. Bechtold, R. R. Pool, V. L. King, and K. G. Mathews. "Avian Fracture Healing Following Stabilization with Intramedullary Polyglycolic Acid Rods and Cyanoacrylate Adhesive vs. Polypropylene Rods and Polymethylmethacrylate." Veterinary and Comparative Orthopaedics and Traumatology 07, no. 04 (1994): 158–69. http://dx.doi.org/10.1055/s-0038-1633090.

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SummaryAvian fracture healing was evaluated for twelve weeks following the repair of transverse mid-diaphyseal humeral fractures. Radiographic, histological, and biomechanical assessment of healing was used to compare a currently used method of repair - a permanent intramedullary polypropylene rod and polymethylmethacrylate bone cement, to a new biodegradable repair technique which utilized intramedullary polyglycolic acid rods and cyanoacry-late adhesive. Histological response to the biodegradable implants consisted of a granulomatous foreign body reaction that did not impair fracture healing

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Gajdobranski, Djordje, and Dragana Zivkovic. "Physiology of fracture healing: New aspects." Medical review 56, no. 1-2 (2003): 39–42. http://dx.doi.org/10.2298/mpns0302039g.

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Introduction Skeletal system has a great regenerative potential, but it isn't the case with other tissues. Bone fracture healing includes a complex cascade of processes at cellular and biochemical levels, ending with a complete structural and functional restoration of the damaged bone. Impaired healing occurs in 5-10% of all fractures, manifesting as delayed union or non-union Such a high incidence of impaired healing certainly presents a problem, and therefore, permanent research regarding physiology of fracture healing is justified. Phases of fracture healing In this paper we described four

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Massari, Leo, Francesco Benazzo, Francesco Falez, et al. "Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study." BioMed Research International 2018 (2018): 1–7. http://dx.doi.org/10.1155/2018/1809091.

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Background. Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time. Methods. The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fu

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Chen, Gongfa, Zongchao Liu, Yong Zhang, Jiqiao Zhang, Fangsen Cui, and Minglong Xu. "Biomechanical Assessment for Healing Progression of Fractured Long Bones: Comparisons of Various Methods Using Beam Models." International Journal of Applied Mechanics 08, no. 06 (2016): 1650074. http://dx.doi.org/10.1142/s1758825116500745.

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Measurements of various effective stiffnesses have been suggested as non-invasive biomechanical methods to assess healing status of a fractured long bone. This paper has compared the sensitivities of five assessment methods for fracture healing of long bones: torsion, compression, 3-point bending, 4-point bending and cantilever bending. A fractured human femur is modeled by an Euler beam and Castigliano’s theorem is used to obtain the effective stiffnesses of the fractured bone. The variations of the effective stiffnesses of the fractured bone with the healing status of the callus have been in

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Gao, Hui, Jinming Huang, Quan Wei, and Chengqi He. "Advances in Animal Models for Studying Bone Fracture Healing." Bioengineering 10, no. 2 (2023): 201. http://dx.doi.org/10.3390/bioengineering10020201.

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Fracture is a common traumatic injury that is mostly caused by traffic accidents, falls, and falls from height. Fracture healing is a long-term and complex process, and the mode of repair and rate of healing are influenced by a variety of factors. The prevention, treatment, and rehabilitation of fractures are issues that urgently need to be addressed. The preparation of the right animal model can accurately simulate the occurrence of fractures, identify and observe normal and abnormal healing processes, study disease mechanisms, and optimize and develop specific treatment methods. We summarize

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Rothom, Ronnachat, and Patchanee Chuveera. "Differences in Healing of a Horizontal Root Fracture as Seen on Conventional Periapical Radiography and Cone-Beam Computed Tomography." Case Reports in Dentistry 2017 (2017): 1–5. http://dx.doi.org/10.1155/2017/2728964.

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Different locations and healing patterns of horizontal root fractures bear different prognoses. Conventional periapical radiographs have been routinely used for the evaluation of the locations and healing of horizontal root fractures, with the limitation of presenting two-dimensional images. The three-dimensional imaging technology, cone-beam computed tomography (CBCT), has recently gained interest in dental traumatology, in particular for locating and diagnosing root fractures. However, the assessment of healing patterns of horizontal root fracture using CBCT compared to conventional radiogra

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Golubović, Zoran, Predrag Stoiljković, Ivan Golubović, et al. "Complications in the treatment of Segmental tibial fractures." Timocki medicinski glasnik 46, no. 3 (2021): 132–36. http://dx.doi.org/10.5937/tmg2103132g.

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Segmental tibial fractures belong to the group of the most severe fractures of the locomotor system. They are most common in polytraumatized patients. Treatment of segmental tibial fractures can be conservative or operative. Treatment of segmental tibial fractures is accompanied by a number of complications, such as delayed healing, dislocation of fragments in one or the other fracture point, healing of fractures in poor position, non-healing of fractures, aseptic and septic pseudoarthrosis, infection around fixator wedges, wound infection of open segmental tibial fracture, iatrogenic infectio

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Park, K. H. "ROLE OF POLAPREZINC IN FRACTURE HEALING BY DIFFERENTIATIONS OF OSTEOBLAST AND OSTEOCLAST." Orthopaedic Proceedings 106-B, SUPP_1 (2024): 109. http://dx.doi.org/10.1302/1358-992x.2024.1.109.

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Fractures and related complications are a common challenge in the field of skeletal tissue engineering. Vitamin D and calcium are the only broadly available medications for fracture healing, while zinc has been recognized as a nutritional supplement for healthy bones. Here, we aimed to use polaprezinc, an anti-ulcer drug and a chelate form of zinc and L-carnosine, as a supplement for fracture healing. Polaprezinc induced upregulation of osteogenesis-related genes and enhanced the osteogenic potential of human bone marrow-derived mesenchymal stem cells and osteoclast differentiation potential o

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Mohiuddin, M., M. Hasan, M. Shohag, R. N. Ferdousy, M. M. Alam, and N. S. Juyena. "Surgical management of limb fractures in calves and goats." Bangladesh Veterinary Journal 52, no. 1-4 (2018): 46–56. http://dx.doi.org/10.32856/bvj-2018.06.

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The study was conducted to determine the occurrence of fractures in calves and goats at Veterinary Teaching Hospital (VTH), Bangladesh Agricultural University (BAU) and to compare the efficacy of fracture treatment with external and internal fixation using splints and bone plate/wire suture respectively. Patients brought to VTH with the history of automobile accident, trauma and clinical signs suggestive of fractures were subjected to detailed physical, orthopaedic and radiographic examinations to confirm fractures. A total of 6 calves and 4 Black Bengal goats were presented to VTH with limb f

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Bush, M. A., C. Whiting, S. J. Langley-Hobbs, and J. V. Hermer. "Healing of patellar fractures in two kittens." Veterinary and Comparative Orthopaedics and Traumatology 25, no. 02 (2012): 155–59. http://dx.doi.org/10.3415/vcot-11-04-0055.

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SummaryTwo kittens aged between four and five months were presented having sustained patellar fractures. In both cases, healing was subsequently documented radiographically; this has not been reported previously in the literature.One kitten had bilateral patellar fractures – the symptomatic right stifle was treated with a pin and tension-band-wire which later failed, at which point partial patellectomy was performed. The fracture of the left patella was minimally displaced and was treated conservatively. A radiograph of the left patella taken eleven months after initial presentation showed com

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Malinin, Theodore I., and H. Thomas Temple. "Fracture healing." Current Orthopaedic Practice 27, no. 2 (2016): 192–97. http://dx.doi.org/10.1097/bco.0000000000000348.

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Cohen, Jonathan. "Fracture Healing." Journal of Bone & Joint Surgery 70, no. 6 (1988): 958. http://dx.doi.org/10.2106/00004623-198870060-00030.

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Waugh, W. "Fracture healing." Current Orthopaedics 3, no. 1 (1989): 66–67. http://dx.doi.org/10.1016/0268-0890(89)90082-0.

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Sethia, Dimple, Amith Hadhimane, and Kirthi Kumar Rai. "Ultrasonography as an alternative to radiographs in assessing fracture healing." IP International Journal of Maxillofacial Imaging 9, no. 1 (2023): 25–29. http://dx.doi.org/10.18231/j.ijmi.2023.004.

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To determine whether ultrasound can assess healing of bone and check the development of callus prior to conventional radiograph thereby enabling early diagnosis of delayed union or confirmation of union. Fracture healing was evaluated with ultrasonography and radiography on specific intervals until healing was complete; in 20 fracture sites. Based on the findings of ultrasonographic and radiographic scores were assigned to classify healing.18 out of 20 fracture sites had completely healed with mature callus formation at the end of 3 months while only 2 fracture sites showed delayed healing. In

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Dudkiewicz, Israel, Michael Heim, Moshe Salai, and Alexander Blankstein. "ULTRASONOGRAPHIC EVALUATION OF UNION IN LONG BONES FRACTURES." Journal of Musculoskeletal Research 12, no. 02 (2009): 105–12. http://dx.doi.org/10.1142/s0218957709002225.

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Introduction: To follow fracture healing, radiography is commonly used, but it is not sensitive to the early stages of this healing process when nonossified callus is formed. Hence, radiography can lag behind the physiological events of bone healing by some weeks. Although the use of ultrasound for fracture diagnosis has been reported previously, mainly in children, the clinical use of ultrasound to follow fracture healing has rarely been commented on. The goal of the current study was to test the efficiency and efficacy of ultrasound as an alternative method for follow-up of fracture healing.

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Kyllonen, Kelsey M., Keith L. Monson, and Michael A. Smith. "Postmortem and Antemortem Forensic Assessment of Pediatric Fracture Healing from Radiographs and Machine Learning Classification." Biology 11, no. 5 (2022): 749. http://dx.doi.org/10.3390/biology11050749.

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A timeline of pediatric bone healing using fracture healing characteristics that can be assessed solely using radiographs would be practical for forensic casework, where the fracture event may precede death by days, months, or years. However, the dating of fractures from radiographs is difficult, imprecise, and lacks consensus, as only a few aspects of the healing process are visible on radiographs. Multiple studies in both the clinical and forensic literature have attempted to develop a usable scale to assess pediatric bone healing on radiographs using various healing characteristics. In cont

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Huang, Yan, Yongqiang Xu, Siyin Feng, Pan He, Bing Sheng та Jiangdong Ni. "miR-19b enhances osteogenic differentiation of mesenchymal stem cells and promotes fracture healing through the WWP1/Smurf2-mediated KLF5/β-catenin signaling pathway". Experimental & Molecular Medicine 53, № 5 (2021): 973–85. http://dx.doi.org/10.1038/s12276-021-00631-w.

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AbstractBone marrow mesenchymal stem cell (BMSC)-derived exosomes have been found to enhance fracture healing. In addition, microRNAs contributing to the healing of various bone fractures have attracted widespread attention in recent years, but knowledge of the mechanisms by which they act is still very limited. In this study, we clarified the function of altered microRNA-19b (miR-19b) expression in BMSCs in fracture healing. We modulated miR-19b expression via mimics/inhibitors in BMSCs and via agomirs in mice to explore the effects of these changes on osteogenic factors, bone cell mineraliza

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Ekegren, Christina, Elton Edwards, Richard de Steiger, and Belinda Gabbe. "Incidence, Costs and Predictors of Non-Union, Delayed Union and Mal-Union Following Long Bone Fracture." International Journal of Environmental Research and Public Health 15, no. 12 (2018): 2845. http://dx.doi.org/10.3390/ijerph15122845.

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Fracture healing complications are common and result in significant healthcare burden. The aim of this study was to determine the rate, costs and predictors of two-year readmission for surgical management of healing complications (delayed, mal, non-union) following fracture of the humerus, tibia or femur. Humeral, tibial and femoral (excluding proximal) fractures registered by the Victorian Orthopaedic Trauma Outcomes Registry over five years (n = 3962) were linked with population-level hospital admissions data to identify two-year readmissions for delayed, mal or non-union. Study outcomes inc

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ÇOKCOŞKUN YILMAZ, Çağıl, and Cenk YARDIMCI. "Minimally invasive plate osteosynthesis (MİPO) in veterinary orthopedics." Journal of Istanbul Veterinary Sciences 6, no. 2 (2022): 47–51. http://dx.doi.org/10.30704/http-www-jivs-net.1111320.

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The current increase in the numbers of fracture treatment by plate osteosynthesis in veterinary medicine is leading to the production of specific plates for different types of fractures. Recent studies about fracture healing show that MIPO procedure is superior for faster union and healing by decreased contamination risk, faster return of function, lower complication rates and blood supply preservation. By now, indirect reduction technics are more valuable in preservation of the biological structure of bone than full anatomic reduction techniques. Day by day, MIPO becomes more popular in veter

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Ünsal, Mısra Özalp, Betul Kargul, and Muesser Ahu Yilmaz. "PROFILE OF COMPLICATED/UNCOMPLICATED CROWN FRACTURES AND HEALING COMPLICATIONS IN PERMANENT TEETH - A RETROSPECTIVE STUDY." International Journal of Medical Science and Dental Health 11, no. 01 (2025): 06–15. https://doi.org/10.55640/ijmsdh-11-01-02.

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Purpose: This retrospective study analyses the profile of uncomplicated/complicated crown fractures in permanent teeth, the frequency of healing complications, and types of treatment methods. Methods: The trauma forms of patients who were registered with uncomplicated/complicated crown fractures from 2016 to 2019 were evaluated. Long-term treatment outcomes were analyzed from patient radiographs using the Periapical Index. The relationship between categorical variables was tested with the Chi-square test. Logistic regression analysis was performed to search for an association between the type

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West, P. G., G. R. Rowland, S. C. Budsberg, and D. N. Aron. "Histomorphometric and angiographic analysis of bone healing in the humerus of pigeons." American Journal of Veterinary Research 57, no. 7 (1996): 1010–15. http://dx.doi.org/10.2460/ajvr.1996.57.07.1010.

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Abstract Objective To evaluate the vascular supply and quantitatively compare the periosteal and endosteal callus formed during fracture healing. Design 36 pigeons were allotted to 2 groups. In each bird, 1 humerus was surgically osteotomized. The wing with the fractured humerus in birds of the first group was infused with a microparticle barium solution, and the humerus was harvested for angiography. Pigeons of the second group were injected with the labels oxytetracycline and calcein. The fractured humerus in each of these birds was harvested for histomorphometry. Animals 36 nine-month-old p

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M. Abdulla, Osman, Firas H. Aboushaar, and Naif M. Alshaeri. "Enhancing Tibial and Fibular Fracture Healing: A Case Report on the Value of Dynamization." JOURNAL OF HEALTHCARE SCIENCES 03, no. 11 (2023): 498–503. http://dx.doi.org/10.52533/johs.2023.31107.

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Background: Tibial and fibular fractures, commonly resulting from high-energy traumas such as road traffic accidents, present difficulties in their management due to displacement, instability, and the requirement for surgical intervention. Case presentation: We present a 27-year-old male patient with a tibial and fibular fracture managed with intramedullary nail fixation and subsequent dynamization. The aim is to highlight the clinical significance of dynamization in addressing delayed healing and non-union in fractures. Clinical assessment and radiographic evaluation were performed to diagnos

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Morcos, M. W., H. Al-Jallad, J. Li, et al. "PHOSPHO1 is essential for normal bone fracture healing." Bone & Joint Research 7, no. 6 (2018): 397–405. http://dx.doi.org/10.1302/2046-3758.76.bjr-2017-0140.r2.

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Objectives Bone fracture healing is regulated by a series of complex physicochemical and biochemical processes. One of these processes is bone mineralization, which is vital for normal bone development. Phosphatase, orphan 1 (PHOSPHO1), a skeletal tissue-specific phosphatase, has been shown to be involved in the mineralization of the extracellular matrix and to maintain the structural integrity of bone. In this study, we examined how PHOSPHO1 deficiency might affect the healing and quality of fracture callus in mice. Methods Tibial fractures were created and then stabilized in control wild-typ

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Cain, Jarrett D., Michelle Titunick, Patricia McLaughlin, and Ian Zagon. "Effects of Local Opioid Antagonist on Diabetic Fracture Rat Model." Foot & Ankle Orthopaedics 3, no. 3 (2018): 2473011418S0017. http://dx.doi.org/10.1177/2473011418s00178.

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Category: Diabetes Introduction/Purpose: Complications associated with the diabetes include increased incidence of fracture healing, delayed fracture healing, delayed osteoblasts cell replication, decreased angiogenesis, migration and/or osteoblast cell differentiation. The cellular events involved in bone healing are adversely affected by diabetes; however, can be modulated by the Opioid Growth Factor (OGF)–OGF receptor (OGFr) is an inhibitory peptide that downregulates DNA synthesis in a tissue nonspecific manner. Diabetes is associated with elevated serum levels of OGF and dysregulation of

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Bastos, Hugo José Santos, Key Fabiano Souza Pereira, Luiz Fernando Tomazinho, Marcos Roberto dos Santos Frozoni, and Élida Boaventura Mendes. "Spontaneous healing response of oblique root fracture: case report with 4-year follow-up." Research, Society and Development 10, no. 3 (2021): e30710313144. http://dx.doi.org/10.33448/rsd-v10i3.13144.

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Root fractures can involve the dentin, cementum, and pulp and commonly can occur as oblique fractures with varying orientations. The aim of this study was to demonstrate the maintenance of pulp health in a tooth with a fractured root without any endodontic treatment and to discuss the advantage of cone-bean computed tomography (CBCT) compared with traditional radiographs in the diagnosis of oblique root fractures. Intra-oral radiography of tooth 11 revealed a horizontal root fracture at the level of the apical third, while the sagittal CBCT slice reveals a complete fracture line running obliqu

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