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Rozprawy doktorskie na temat „Functionnal genes”

Autor: Grafiati

Data publikacji: 11 stycznia 2025

Data aktualizacji: 31 lipca 2025

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1

Heglind, Mikael. "Functional studies of two forkhead genes /." Göteborg : Institute of Biomedicine, Department of Medical and Clinical Genetics, The Sahlgrenska Academy at University of Gothenburg, 2010. http://hdl.handle.net/2077/21481.

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Rice, Kim. "Functional analysis of the HOX11 target genes ALDH1A1 and FHL1." Thesis, Rice, Kim (2004) Functional analysis of the HOX11 target genes ALDH1A1 and FHL1. PhD thesis, Murdoch University, 2004. https://researchrepository.murdoch.edu.au/id/eprint/277/.

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HOX11 is a developmental regulator that plays a crucial role in the normal development of the spleen and is also aberrantly activated by the t(10;14)(q24;q11) and variant t(7;10)(q35;q24) translocations in a subset of T-cell acute lymphoblastic leukaemias (TALLs). The recent finding that HOX11 is deregulated in up to 40% of childhood TALLs when abnormalities not detected by cytogenetics are included, suggests that the over-expression of HOX11 and subsequent deregulation of downstream target genes are critical events in the progression of this tumour type. To date, three candidate HOX11 target

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Rice, Kim. "Functional analysis of the HOX11 target genes ALDH1A1 and FHL1 /." Access via Murdoch University Digital Theses Project, 2004. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20051012.93820.

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Fernandes, Alinda. "Lentiviral-mediated gene delivery to investigate the functional role of neuropsychiatric genes." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/lentiviralmediated-gene-delivery-to-investigate-the-functional-role-of-neuropsychiatric-genes(b6392e47-e94b-4e64-b343-e7eafd696b26).html.

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Genetic studies have led to the identification of several candidate genes, some novel and others established, that may contribute to the risk of developing neuropsychiatric disorders. For example, dopamine receptor genes are established candidates for a number of psychiatric disorders such as Parkinson’s Disease, alcohol addiction and mood disorders. On the other hand, a gene of unknown function, AUTS2 (Autism susceptibility candidate 2), has recently been associated with alcohol consumption in a GWAS meta-analysis performed by our group. Interestingly, it has been associated with a broad rang

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Kacar, Betül, Eva Garmendia, Nurcan Tuncbag, Dan I. Andersson, and Diarmaid Hughes. "Functional Constraints on Replacing an Essential Gene with Its Ancient and Modern Homologs." AMER SOC MICROBIOLOGY, 2017. http://hdl.handle.net/10150/625744.

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Genes encoding proteins that carry out essential informational tasks in the cell, in particular where multiple interaction partners are involved, are less likely to be transferable to a foreign organism. Here, we investigated the constraints on transfer of a gene encoding a highly conserved informational protein, translation elongation factor Tu (EF-Tu), by systematically replacing the endogenous tufA gene in the Escherichia coli genome with its extant and ancestral homologs. The extant homologs represented tuf variants from both near and distant homologous organisms. The ancestral homologs re

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6

Fan, Li. "Map based candidate gene cloning and functional analysis of genes involved in VLCFAs synthesis." [Ames, Iowa : Iowa State University], 2007.

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7

Ashwood, Lauren M. "Characterising the functional venom profiles of sea anemones." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/227457/1/Lauren_Ashwood_Thesis.pdf.

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This project examined the relationship between the ecological roles of venom and patterns of venom production in sea anemones. It was found that sea anemones produce multiple venoms and that these distinct venoms are associated with the ecological functions of envenomating structures. Overall, this information provides insights into the ecological context of venom regulation and provides a rational framework for pharmaceutical bioprospecting in sea anemones.

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8

Kolle, Gabriel Victor. "Functional analysis of vertebrate Crim1 /." [St. Lucia, Qld.], 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16804.pdf.

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9

Couldrey, Christine. "A gene trap approach to identify the functional role of genes expressed during murine gametogenesis." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624246.

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10

Tronnersjö, Susanna. "Functional studies of RNA polymerase II-dependent transcription in yeast Saccharomyces cerevisiae /." Uppsala : Department of Plant Biology and Forest Genetics, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/2006109.pdf.

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11

Smoler, Gunilla Kanter. "Functional characterization of conserved checkpoint genes." Göteborg, Sweden : Dept. of Cellular and Molecular Biology, Göteborg University, 1998. http://books.google.com/books?id=vM5qAAAAMAAJ.

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12

Swiatek, Magdalena. "Functional analysis of plastid-encoded genes." Diss., lmu, 2002. http://nbn-resolving.de/urn:nbn:de:bvb:19-1680.

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13

El-Hassi, Mohamed F. "Functional analysis of some yeast genes." Thesis, Durham University, 1997. http://etheses.dur.ac.uk/4767/.

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A series of mutant strains of the yeast Saccharomyces cerevisiae that are sensitive to osmotic stress and also have a defect in vacuolar biogenesis have been isolated (M. Latterich, PhD Thesis 1992). The mutations that cause this pleiotropic phenotype are termed ssv, for salt sensitive vacuolar mutants. Complementation analysis has revealed that ssv mutations fall into one of 18 complementation groups. A MAP kinase related signal transduction pathway, termed the HOG pathway for High Osmolarity Glycerol, has been identified in yeast. This pathway senses osmotic stress and invokes the cellular r

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14

Kanter, Smoler Gunilla. "Functional characterisation of conserved checkpoint genes." Göteborg : [s.n.], 1998. http://catalog.hathitrust.org/api/volumes/oclc/45150869.html.

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15

Read, Jason Tyler. "Towards conditional gene inactivation in the mouse colon and functional analysis of genes influencing colorectal carcinogenesis." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/22575.

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Dysregulation of the Wnt signalling pathway is implicated in the carcinogenic transformation of normal cells in a number of human tissues. Mutations in Wnt pathway signalling molecules appear to be particularly important in the development of colorectal neoplasia. This thesis investigates the effects of modulating levels of Wnt pathway components on downstream molecules <i>in vivo</i> and <i>in vitro</i>. To examine the effects of loss of Wnt pathway components on the biology of the mouse large intestine work was undertaken to assemble a tissue specific, inducible Cre (CreER<sup>tm</sup>) tran

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16

Papin, Marine. "Efficiency and impact of recurrent microbial inoculation in soil, a lab to field assessment." Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCK051.

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Face à l'urgence de mettre en place des pratiques plus durables pour protéger l'environnement tout en maintenant la production agricole, les inoculants microbiens suscitent un intérêt croissant en raison de leur potentiel pour réduire la dépendance aux intrants synthétiques. Cependant, malgré des décennies de recherche sur les inoculants microbiens du sol, leurs bénéfices sur les rendements agricoles restent très variables en fonction des sols, des climats, des génotypes végétaux et des souches inoculées, rendant les résultats difficiles à prédire et fragilisant in fine la confiance des agricu

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Johnston, David Morris. "Functional genomics of plant chitinase-like genes." Thesis, University of British Columbia, 2006. http://hdl.handle.net/2429/64.

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The Arabidopsis chitinase-like1 (Atctl1) mutant, pom1 is compromised in primary cell wall development, resulting in short roots when grown on high sucrose and shortened hypocotyls when grown in darkness. To better understand this phenotype and the evolution of AtCTL1 and its homologue, AtCTL2, we obtained a large number of CTL sequences and determined the phylogenetic relationships among them. Since microarray analysis had suggested a change in auxin response or homeostasis in pom1, I used the auxin reporter DR5::GUS in the pom1 background to assess changes in distribution. To assess whether t

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18

Patel, Nrupali. "Functional Analyses of Cyst Nematode Parasitism Genes." NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-03102008-221413/.

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Cyst nematodes in the genus Heterodera are sedentary endoparasites that induce elaborate feeding cells within host roots by secreting proteins produced within nematode esophageal glands into plant cells. Functional analyses of selected cyst nematode parasitism genes that encode such secreted proteins was the objective of this dissertation. Homologs of four parasitism genes initially isolated from Heterodera glycines, including Hg4F01 (annexin-like protein), HgSYV46 (CLAVATA3-like plant peptide mimic), Hg4E02 and Hg5D08 (novel proteins with putative host nuclear localization) were isolated from

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19

Thacker, Zubin. "Functional analysis of E. coli specific genes." Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/11457.

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The basis of my research has been to identify and characterise the function of ‘<i>E. coli</i> specific’ genes. <i>E. coli</i> specific genes were identified after comparing 33 gamma proteobacterial genomes at the Microbial Genome Database (MBGD). The database was used to investigate the change in the number of <i>E. coli</i> specific genes since the completion of the first <i>E. coli</i> genome in 1997. Forty nine selected <i>E. coli </i>specific genes were deleted in 38 separate deletion events on the genome of the model <i>E. coli </i>K-12 MG1655 using the modified pKO3 deletion procedure.

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20

Waters, A. M. "Genetic and functional dissection of ciliary genes." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1395927/.

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Ciliopathy disorders are associated with either abnormal formation or function of cilia. Mutations have been described in over 60 ciliary genes to date. With the identification of over 1,000 ciliary polypeptides, other disorders exhibiting ciliopathy features could result from mutations in other ciliary genes. A new ciliopathy disease gene, CENPF, has been identified in a kindred exhibiting midgestation lethality with congenital malformations suggestive of a novel ciliopathy phenotype. Where conventional approaches such as genome-wide linkage analysis and homozygosity mapping had failed, whole

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21

Yu, Man. "Functional Analysis of the Cis-Regulatory Elements I56i, I56ii and I12b that Control Dlx Gene Expression in the Developing Forebrain of Mouse and Zebrafish." Thesis, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20165.

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The vertebrate Dlx gene family consists of multiple convergently transcribed bigene clusters and encodes a group of homeodomain-containing transcription factors crucial for the development of forebrain, branchial arches, sensory organs and limbs. At least four cis-regulatory elements (CREs) are responsible for Dlx expression in the forebrain: URE2 and I12b in the Dlx1/Dlx2 (zebrafish dlx1a/dlx2a) locus, and, I56i and I56ii in the Dlx5/Dlx6 (zebrafish dlx5a/dlx6a) locus. Here, we first show that unlike the other three enhancers, mouse I56ii CRE targets a group of GABAergic projection neurons ex

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22

Sung, Young Kwan. "Functional analysis of potato yellow mosaic geminivirus genes." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321667.

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Stival, Sena Juliana. "Structural and functional evolution of genes in conifers." Doctoral thesis, Université Laval, 2017. http://hdl.handle.net/20.500.11794/27679.

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Le développement de nouvelles techniques a accéléré l'exploration structurale et fonctionnelle des génomes des conifères et contribué à l’étude de leur physiologie et leur adaptation aux conditions environnementales. Cette thèse s’intéresse à l’évolution des gènes chez les conifères et (i) fait le point sur les facteurs génomiques qui ont influencé la structure des gènes et (ii) analyse une grande famille de gènes impliqués dans la tolérance à la sécheresse, les déhydrines. Notre étude de la structure génique s’est fait à partir de diverses séquences de l’épinette blanche (Picea glauca [Moench

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24

Wu, Yu. "Identification and Functional Characterization of Adipogenesis-related Genes." University of Toledo Health Science Campus / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=mco1229546422.

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Contos, James John Achilles. "Genomic and functional characterization of lysophospholipid receptor genes /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9945772.

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26

Xue, Song. "Functional analysis of sucrose synthase genes in maize." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0007380.

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27

Thacker, G. "Functional analysis of C.jejuni genes encoding putative peptidases." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536843.

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28

Guo, Xiumei. "Regulatory and functional study of human cytoglobin." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B3860145X.

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29

Zhang, Hao. "Functional characterization of ORF slr0813 in cyanobacterium synechocystis PCC 6803 /." View Abstract or Full-Text, 2002. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202002%20ZHANG.

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Thesis (Ph. D.)--Hong Kong University of Science and Technology, 2002.<br>Includes bibliographical references (leaves 196-212). Also available in electronic version. Access restricted to campus users.

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30

Lestari, Retno. "Functional analysis in Hevea brasiliensis of the HbERF-IXc4 and HbERF-IXc5 genes, two potential orthologs Arabidopsis ERF1 gene." Thesis, Montpellier, SupAgro, 2016. http://www.theses.fr/2016NSAM0042/document.

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Le caoutchouc naturel (CN), a cis-1,4-polyisoprene, est produit principalement par Hevea brasiliensis. Le CN est un matériau très important pour l’industrie du transport et médicale. La demande en CN augmente d’année en année. Le CN est obtenu à partir du latex. Le latex s’écoule des laticifères après saignée de l’écorce des hévéas. L’éthéphon, un libérateur d’éthylène, peut être appliqué sur certains clones d’hévéa pour stimuler la production de latex. La saignée et la stimulation à l’éthéphon sont des stress de récolte conduisant à la production de métabolites secondaires et par conséquence

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31

Sawers, Ruairidh J. H. "Functional analysis of bundle sheath defective2." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342541.

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Gyoergy, Andras. "Functional modularity in gene networks." Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/103726.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2016.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 141-150).<br>This thesis addresses two sources of context-dependence in both systems and synthetic biology: retroactivity and competition for shared cellular resources. The contribution is the development of simple-to-use computational tools that aide the analysis and design of multi-module genetic systems. These tools are a result of combining mathematical modeling and theoretical analysis

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RIGAMONTI, AURORA. "Functional characterization of SMARCA2 gene." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2016. http://hdl.handle.net/10281/130275.

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My PhD project is based on the characterization of the SMARCA2 gene. On one hand, I focused my attention on the role of SMARCA2 product, the protein brahma (BRM), in the regulation of alternative pre-mRNA splicing. On the other hand, I investigated the transcriptional regulation of SMARCA2 expression. My first project derived from a comparative evaluation and validation of microarray data from two mitochondrial stress models. The first model represented by an acute mitochondrial stress is constituted by human SH-SY5Y neuroblastoma cells treated with Paraquat (PQ), while the second model is a

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34

Svingen, Terje, and n/a. "Hox Transcription Factors: Their Involvement in Human Cancer Cells and In Vitro Functional Specificity." Griffith University. School of Biomolecular and Biomedical Science, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050830.135356.

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Hox genes are regulatory genes encoding small proteins containing a highly conserved 61-amino acid motif, the homeodomain, that enables Hox proteins to bind to DNA at specifically recognised binding sites and transcriptionally activate their target genes. In mammalian species there are 39 Hox genes and they are structural and functional homologs of the Drosophila homeotic complex (Horn-C). During embryogenesis and early development the Hox genes are expressed in a spatiotemporal fashion, where they operate as master transcriptional regulators. Hox genes are further expressed in fully different

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Svingen, Terje. "Hox Transcription Factors: Their Involvement in Human Cancer Cells and In Vitro Functional Specificity." Thesis, Griffith University, 2005. http://hdl.handle.net/10072/365774.

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Hox genes are regulatory genes encoding small proteins containing a highly conserved 61-amino acid motif, the homeodomain, that enables Hox proteins to bind to DNA at specifically recognised binding sites and transcriptionally activate their target genes. In mammalian species there are 39 Hox genes and they are structural and functional homologs of the Drosophila homeotic complex (Horn-C). During embryogenesis and early development the Hox genes are expressed in a spatiotemporal fashion, where they operate as master transcriptional regulators. Hox genes are further expressed in fully different

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36

Hoffmann, Eva R. "Functional analysis of MLH1." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249558.

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Man, Kwun-nok Mimi. "Functional implications of cytoglobin, a novel protein, in liver fibrosis." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38820730.

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38

Linnenbrink, Miriam [Verfasser]. "Population genetic and functional analysis of the B4galnt2 gene in the genus Mus (Rodentia; Muridae) / Miriam Linnenbrink." Kiel : Universitätsbibliothek Kiel, 2012. http://d-nb.info/1053683189/34.

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Garrett, Christine. "Functional mapping of pea legumin upstream regulatory elements using TI plasmid vectors." Thesis, Durham University, 1991. http://etheses.dur.ac.uk/6041/.

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The leg A gene from Pisum sativum L. has been extensively characterised and a distinct pattern of developmental and organ-specific gene expression demonstrated. Homology between legumin genes from other species has given some indication of those sequences which may be responsible for the regulation at the level of transcription. This study was designed to provide a functional analysis of the upstream sequences. A number of plasmid vectors containing a maximum of 1.2 kb of upstream sequence from the leg A gene of Pisum sativum I., ligated to the coding region of the nopaline synthase (nos) gene

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40

Nganvongpanit, Korakot. "Functional analysis of genes during bovine preimplantation embryo development." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980875153.

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Lee, Heon-Jin. "Functional analysis of the murine genes, MOCS1 and Sox15." [S.l.] : [s.n.], 2003. http://webdoc.sub.gwdg.de/diss/2003/lee/lee.pdf.

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42

Akhavantabasi, Shiva. "Functional Characterization Of Two Potential Breast Cancer Related Genes." Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614275/index.pdf.

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Cancer may arise as a result of deregulation of oncogenes and/or tumor suppressors. Although much progress has been made for the identification of such cancer related genes, our understanding of the complex tumorigenesis pathways is still not complete. Therefore, to improve our understanding of how certain basic mechanisms work in normal and in cancer cells, we aimed to characterize two different breast cancer related genes. First part of the study focused on subcellular localization USP32 (Ubiquitin Specific Protease 32) to help understand the function of this uncharacterized gene. USP32 is a

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Thorsteinsdottir, Unnur. "Functional analysis of selected Hox homeobox genes in hematopoiesis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq25175.pdf.

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Feiz, Leila. "Functional analysis of puroindoline genes in wheat (Triticum aestivum)." Thesis, Montana State University, 2008. http://etd.lib.montana.edu/etd/2008/feiz/FeizL1208.pdf.

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Grain hardness variation has large effects upon many different end-use properties of wheat (Triticum aestivum). The Hardness (Ha) locus consisting of the Puroindoline a and b genes (Pina and Pinb) controls the majority of grain hardness variation. Starch production is a growing end-use of wheat. The first objective of this study was to estimate the differences in starch yield due to natural and transgenically conditioned grain hardness differences. To accomplish this goal, a small scale wet milling protocol was used to characterize the wet milling properties of two independent groups of isogen

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Carter, D. P. F. "Long-range functional interactions between genes and regulatory elements." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597329.

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The mouse b-globin locus contains four genes that are expressed throughout development in the same order they are arranged along chromosome 7. Upstream of the genes is a powerful regulatory element called the locus control region (LCR). The LCR is absolutely required for high-level expression of the b-globin genes. The models to explain how LCRs (and enhancers in general) are able to activate expression of the genes fall into two categories: contact and non-contact. The contact models propose that the LCR and the gene form a physical interaction that leads to active transcription. The non-cont

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46

Beswick, Richard William. "Functional characterisation of the genes mutated in dyskeratosis congenita." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8705.

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Dyskeratosis congenita (DC) is a multi system disorder that exhibits considerable clinical and genetic heterogeneity. It is characterised by mucocutaneous features, bone marrow failure and a predisposition to cancer. Research has identified mutations affecting several telomerase components and patients often have short telomeres, implicating defective telomere maintenance in this disease. Affected components include dyskerin, NOP10 and NHP2, which together with GAR1 form a protein core common to telomerase and all other H/ACA ribonucleoprotein complexes (H/ACA RNPs). Initially characterised as

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47

Alvarez-Saavedra, Ezequiel (Ezequiel Andrès). "Functional analysis of the microRNA genes of C. elegans." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/42948.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2008.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (p. 231-252).<br>MicroRNAs (miRNAs) were discovered in C. elegans during studies of the control of developmental timing. MicroRNAs are a large class of short non-coding RNAs found in many viruses, plants and animals that regulate gene expression through sequence-specific base-pairing with target mRNAs. Initial studies since the i

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48

Fairclough, Victoria Ruth. "Functional Analysis of Novel Essential Genes of Staphylococcus aureus." Thesis, University of Sheffield, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522041.

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Bebek, Gurkan. "Functional Characteristics of Cancer Driver Genes in Colorectal Cancer." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1495012693440067.

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Challa, Anil Kumar. "Identification and functional analysis of Zebrafish orthologs of genes." Connect to this title online, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1061302731.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Document formatted into pages; contains 119 p. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 19.

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