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Rozprawy doktorskie na temat „Gap junctions”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 19 października 2024

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1

Sheela, Thomas Vinaya. "Regulation of Connexin40 Gap Junctions." Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_diss/55.

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Gap junctions provide direct electrical and biochemical communication between cardiomyocytes in the heart. Connexin40 (Cx40) is the major connexin in the atria of the heart and little is known regarding its regulation. Thus, the goal was to investigate the regulation of Cx40 in both physiological and pathophysiological conditions. The first objective of this thesis was to determine whether Cx40 gap junctions were regulated by â-adrenergic receptor activation. Cx40 has previously been shown to be acutely activated by cAMP, this cAMP-induced increase in Cx40-mediated cell-to-cell dye transfer ha

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2

Carolan, E. J. "Gap junctions in lymphocyte ontogeny." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.233181.

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Nishimura, Tamiko. "Gap junctions in early human placental development." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63198.pdf.

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4

Ko, Yu-Shien. "Connexin heterogeneity in vascular cell gap junctions." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393781.

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5

Pintsch, Monika. "Cx37 abhängige Calciumsignalausbreitung durch myoendotheliale Gap Junctions." Diss., Ludwig-Maximilians-Universität München, 2015. http://nbn-resolving.de/urn:nbn:de:bvb:19-182614.

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Eine effektive Regulation der Gewebedurchblutung erfordert eine Koordination der Reaktion einzelner Gefäßzellen bzw. verschiedener Gefäßabschnitte. Der zur Koordination erforderliche interzelluläre Signalaustausch kann zumindest teilweise über Gap Junction-Kanäle erfolgen, die als interzelluläre Verbindungen den Austausch von elektrischen und chemischen Signalstoffen zwischen benachbarten Zellen ermöglichen. Dieser Austausch kann über die Modulation der Permeabilität von Gap Junction-Kanälen reguliert werden. Aus Untersuchungen an Modellzellen (HeLA-Zellen) war bereits bekannt dass NO eine sol

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6

Rahman, Salman. "Biochemical and immunological studies on gap junctions." Thesis, University College London (University of London), 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.266786.

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7

Kalapothakis, Evanguedes. "Expression and biomolecular assembly of gap junctions." Thesis, Open University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332822.

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8

Calkins, Travis L. "Gap Junctions in the Mosquito, Aedes aegypti." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu149217328492135.

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9

Gakhar, Gunjan. "Role of gap junctions in breast cancer." Diss., Manhattan, Kan. : Kansas State University, 2009. http://hdl.handle.net/2097/2228.

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10

Moore, Lisa Karen. "Regulation of gap junctions in vascular smooth muscle." Diss., The University of Arizona, 1993. http://hdl.handle.net/10150/186240.

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Gap junctions form low resistance pathways between neighboring cells and thereby provide for coordination of tissue function. In vascular smooth muscle these channels are believed to be important in maintenance of and coordination of changes in vessel tone. In this study we demonstrate that vascular smooth muscle cells from vessels of different origin and species differ in the connexin protein expressed as well as in the size of the channel formed by these proteins. We have shown that pig coronary and rat mesentery express mRNA for Cx43 and exhibit a single channel conductance of 60 or 80 pS r

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11

Heyman, Nathanael Stanlee. "Selectivity of Connexin43 and Connexin40 Comprised Gap Junctions." Diss., The University of Arizona, 2007. http://hdl.handle.net/10150/196060.

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Gap junctions are aggregates of intercellular channels each formed of protein subunits termed connexins (Cx). Recently published data show that junctional dye permeability relative to conductance (permselectivity) varies across several orders of magnitude for Cx43 junctions, suggesting variable selectivity of the comprising Cx43 channels. Logical candidates for this variable selectivity are variability in charge or size selectivity. Consequently, junctional charge and size selectivities were determined in the current study by simultaneous measurement of junctional permeance to dyes of differin

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12

Harfst, Elizabeth. "A biochemical and immunological study of cardiac gap junctions." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46332.

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13

Doble, Bradley Wayne. "Cardiac gap junctions, a target of growth factor signaling." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ57507.pdf.

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14

Thomas-Brown, Terri Petrese. "Natural Retinoid Modulation of Epiderman gap junctions and differentiation." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 1987. http://digitalcommons.auctr.edu/dissertations/1185.

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Modulation of mouse epidermal gap junctions and differentiation in response to a natural retinoid, retinyl palmitate (RP), was evaluated. This is the first report of gap junction isolation and partial protein characterization from normal or retinoid-treated epidermis. Adult male Swiss Webster mice received parenteral injections of 13,750 International Units (IU) of RP for 12 days. Skin specimens were excised and analyzed by transmission electron microscopy (TEM) for morphologic changes in gap junctions and the epidermis. Gap junction proteins were isolated by discontinuous sucrose gradient cen

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15

Tearle, Adam William. "Structural and functional aspects of gap junctions in invertebrates." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395011.

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16

Wang, Chiuhui Mary. "The role of gap junctions in diabetic wound healing." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1446186/.

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The process of wound healing is slow in diabetes, often resulting in infection or chronic wounds that can lead to amputation. Cell-cell communication through the gap junction protein connexin 43 (Cx43) and the dynamic regulation of Cx43 expression play pivotal roles in the wound healing process. Acute streptozotocin-induced diabetes in rats altered connexin expression in uninjured back skin, decreasing Cx26, Cx30 and Cx43 protein and gap junctional communication in the epidermis and increasing Cx43 protein and communication in the dermis. Diabetes was also found to alter the dynamic changes of

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17

Lazzaro, Massimo. "Potential involvement of gap junctions in pathology of addiction." Doctoral thesis, Università di Catania, 2013. http://hdl.handle.net/10761/1341.

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Cocaine abuse represents a huge social problem for the widespread in the world and for the many health risks associated. Moreover, a significative percentage of cocaine users develop an addiction with loss of control on drug intake. Several molecular modifications occurs with cocaine use, some of which seem occur only in addicted individuals. Gap junctions (GJs) allow cellular communication, indeed they are fundamental to regulate cellular synchronization, cellular growth and metabolic coordination in tissues. We analyzed the role of GJs proteins in the cocaine s mechanism of action and furth

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18

Li, Wing-man Michelle, and 李穎雯. "Gap junction regulates the blood-testis barrier dynamics during spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45450225.

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19

Butkevich, Eugenia. "Submembrane cytoskeleton-regulated assembly and functional activity of gap junctions." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972736174.

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20

Edwards, Jill Carole. "Gap junctions and connexin expression in the mouse inner ear." Thesis, University College London (University of London), 2004. http://discovery.ucl.ac.uk/1446883/.

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Gap junctions are sites of direct communication between adjacent cells where clusters of channels in the membrane of one cell contact clusters of channels in the membrane of the neighbouring cell. Six constituent proteins, known as connexins (Cx), make up each hemi-channel. The channels allow the passage of small metabolites (up to 1200 Daltons in size), ions, and second messengers between cells, coupling them both electrically and chemically. This provides a means for signalling between the cells that enables co-ordinated activity of cells in a tissue and may permit one cell to trigger a resp

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21

Bani-Yaghoub, Mahmud. "The role of gap junctions in neuronal and astroglial differentiation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0013/NQ42495.pdf.

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22

Eloff, Benjamin Charles. "ROLE OF GAP JUNCTIONS IN THE GENESIS OF CARDIAC ARRHYTHMIAS." Case Western Reserve University School of Graduate Studies / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=case1106579517.

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23

Hinley, Jennifer Susan. "Cx32 gap junctions in human urothelial barrier generation and restitution." Thesis, University of York, 2015. http://etheses.whiterose.ac.uk/13003/.

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The ability of the urothelium to act as a urinary barrier is afforded by two key features: 1) It has the tightest barrier function of any epithelium, generated by tight junctions which assemble upon differentiation; 2) In response to damage, the quiescent urothelium can rapidly switch to a regenerative phenotype to enable regeneration and restitution of barrier function. Central to repair is the ability for the urothelium to sense damage; a process hypothesised to involve cell-cell communication. Direct cell-cell communication occurs through gap junctions, channels comprising connexin (Cx) pro

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24

Holzbecher, André Jörg. "Function of interneuronal gap junctions in hippocampal sharp wave-ripples." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/19364.

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Eine einzigartige experimentelle Beobachtung, welche die Basis für eine ganzheitliche, neurowissentschafliche Theorie für Gedächtnis darstellen könnte, sind sharp wave-ripples (SWRs). SWRs werden in lokalen Neuronennetzwerken erzeugt und sind wichtig für Gedächtniskonsolidierung; SWRs sind charakteristische Ereignisse der lokalen Feldpotentiale im Hippocampus des Säugetiers, die in Phasen von Schlaf und Ruhe vorkommen. Eine SWR besteht aus einer sharp wave, einer ≈ 100 ms langen Auslenkung des Feldpotentials, welche mit ripples, 110–250 Hz Oszillationen, überlagert ist. Jüngste Experimente be

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25

Neef, Martin. "Expression der Connexine 40, 43 und 45 unter chronischer Stimulation durch Insulin und die Wachstumsfaktoren IGF-1, VEGF, TGF-β und FGF-2 bei neonatalen Rattenkardiomyozyten". Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-209143.

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Gap Junctions als wichtigste Elemente der Zelle zur Ermöglichung einer interzellulären Kommunikation erlauben eine koordinierte Antwort auf externe und interne Stimuli und somit ein Zusammenspiel von Zellgruppen und Organen im Gesamtorganismus. In der vorliegenden Arbeit wurde der Einfluss einer mittelfristigen und chronischen Stimulation neonataler Rattenkardiomyozyten durch Insulin und den Wachstumsfaktoren Insulin-like Growth Factor-1 (IGF-1), Vascular Endothelial Growth Factor (VEGF), Transforming Growth Factor-β (TGF-β) und Fibroblast Growth Factor-2 (FGF-2) auf die Expression der Connexi

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26

Giessmann, Daniel. "Funktionelle Korrelation von Zytoskelett und gap junctions am Modell der Linsenepithelzelle." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968700454.

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27

Khandoga, Natascha. "Einfluss von oxLDL auf die Apoptoseinduktion und Zellkopplung über Gap Junctions." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-74235.

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28

Lall, Varinder Kaur. "The influence of connexin 36 containing gap junctions on autonomic activity." Thesis, University of Leeds, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595850.

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Gap junctions (GJ) connect the cytoplasm of two adjacent cells and have two probable functions, synchronisation of networks by direct electrical communication and allowing. the passage of small molecules. This thesis examines the distribution patterns and physiological roles of the neuronal GJ sub unit connexin 36 (Cx36) in autonomic and respiratory control. Using the working heart brainstem preparation of the rat and mouse recordings were made during baseline and during peripheral chemoreceptor and baroreceptor stimulation. Central sympathetic drive was attenuated with the addition of 1 μM of

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29

Dietze, Anna. "Die Wirkung von Desipramin an kardialen Gap Junctions unter ischämischen Bedingungen." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-216543.

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Kardiovaskuläre Erkrankungen in Deutschland führen die Todesursachenstatistik an (19,1 % 2013) und verursachen die höchsten Krankheitskosten (14,5 % 2008) (Statistisches Bundesamt, 2015a,b). Im Rahmen von ischämischen Ereignissen am Herzen kann es zu Rhythmusstörungen kommen. In der Therapie dieser Störungen werden traditionell klassische Antiarrhythmika mit Wirkort Ionenkanal eingesetzt, welche jedoch stets ein proarrhythmisches Potenzial aufweisen. Im Fokus der Forschung der letzten Jahre stehen deswegen Peptide wie AAP10 (Antiarrhythmisches Peptid 10), welche direkt an den Gap Junctions ans

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30

Cao, Jiexin. "The Circadian Rhythm of Gap Junctions between photoreceptors in Goldfish retina." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1468761145.

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31

Elias, Laura Allyn Barker. "The role of gap junctions in the development of the neocortex." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3311338.

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32

Ale-Agha, Niloofar. "Untersuchungen zum Einfluss von Retinoiden, Flavonoiden und Menadion auf interzelluläre Kommunikation über gap junctions." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968651534.

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33

Chandrasekhar, Anjana. "Insights into the mechanisms of growth suppression by connexins in model systems : a dissertation /." San Antonio : UTHSC, 2007. http://proquest.umi.com/pqdweb?did=1375515321&sid=1&Fmt=2&clientId=70986&RQT=309&VName=PQD.

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34

Morrow, Dympna Mary Paula. "Tumour promotion : mechanisms of action and modes of prevention." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322414.

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35

Striedinger, Katharine. "Degeneration and regeneration of the retina after trauma: emphasis on gap junctions." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=973201126.

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36

Schügner, Ricarda. "Synthese von Retinoiden zur Untersuchung der Zell-Zell-Kommunikation via gap junctions." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=968931367.

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37

Pintsch, Monika [Verfasser], and Ulrich [Akademischer Betreuer] Pohl. "Cx37 abhängige Calciumsignalausbreitung durch myoendotheliale Gap Junctions / Monika Pintsch. Betreuer: Ulrich Pohl." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2015. http://d-nb.info/1073825760/34.

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38

Strom, Maria. "Targeting Gap Junctions as a Mechanism and Potential Treatment of Cardiac Arrhythmias." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1262100592.

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39

Dilger, Nadine Saskia [Verfasser]. "Regulation von Ionenkanälen und Gap Junctions während der Zellentwicklung / Nadine Saskia Dilger." Hannover : Gottfried Wilhelm Leibniz Universität Hannover, 2020. http://d-nb.info/1212582489/34.

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40

Bradley, Kathryn Diane. "The Role of Connexin-36 Gap Junctions in Alcohol Intoxication and Reward." BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2055.

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The purpose of this thesis project was to examine the function of connexin-36 (Cx36) gap junctions (GJs) in producing alcohol's intoxicating and rewarding effects. GABA neurons are thought to inhibit dopamine (DA) neurotransmission in the mesocorticolimbic system, which originates in the midbrain ventral tegmental area (VTA) and projects to limbic structures such as the nucleus accumbens (NAcc). The mesolimbic DA system is believed to be the neural substrate of alcohol intoxication and addiction (Tepper, Paladini, & Celada, 1998). Alcohol suppresses the firing rate of GABA neurons in the VTA (

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41

Mok, Wing-yee Bobo. "Expression of Gap-junctional connexin 31 in rat testis /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21254084.

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42

莫穎兒 and Wing-yee Bobo Mok. "Expression of Gap-junctional connexin 31 in rat testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31223205.

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43

Daubrawa, Felicitas Ulrike. "Effekte von Astaxanthin und Canthaxanthin auf die Zell-Zell-Kommunikation über Gap Junctions." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=979445736.

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44

Hundhausen, Christina. "Einfluß der endothelialen Autakoide NO und PGI2 auf die Permeabilität endothelialer Gap Junctions." Diss., lmu, 2003. http://nbn-resolving.de/urn:nbn:de:bvb:19-12703.

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45

Yeh, Hung-I. "Vascular cell gap junctions : diversity of connexin expression in healthy and injured artery." Thesis, Imperial College London, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265945.

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46

Salvage, Samantha. "Modulation of gap junctions and the intracellular resistance pathway in guinea-pig myocardium." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.604348.

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Myocardial intracellular communication via gap junctions (GJ) is fundamental to action potential (AP) propagation facilitating ordered atrial and ventricular contraction. Cardiac arrhythmias can be initiated by increased intracellular (Ca2+), and are associated with abnormal AP conduction due to increased intracellular resistivity (RI) and, specifically, gap junction resistivity (Rj), Recent evidence suggested the Ca2+/calmodulin (CaM)-dependent protein phosphatase calcineurin (Cn) slowed conduction, possibly through increasing RI. This work aimed to demonstrate the role of Cn-dependent pathwa

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47

Bennett, Peter. "Intrinsic Connectivity of the Claustrum : Gap Junctions Demonstrated by Immunohistochemistry and Electron Microscopy." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for nevromedisin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-26190.

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The claustrum is a much neglected nucleus in the brain, whose fuction remains unknown to date. Yet, based on the extensive reciprocal connections it shares with virtually all functional regions of cortex, it most likely serves a far from meaningless purpose. Current hypotheses propose a role in perceptual binding by synchronization of cortical activity. These hypotheses come with a number of assumptions, such as a wide network of connections intrinsic to the claustrum. In this context, gap junctions have been suggested as a means to interconnect portions of the claustrim and to synchronize inc

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48

Greer, Claire Elizabeth. "A role for gap junctions in the growth and development of Drosophila melanogaster." Thesis, University of Sussex, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409962.

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49

Nickel, Regina. "An exploration of the role of gap junctions in the avian inner ear." Thesis, University College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412533.

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50

Recktenwald, Johanna Christina [Verfasser]. "Hyperosmolare Sucrose-Lösung induziert ultrastrukturelle Veränderungen in astrozytären Gap Junctions / Johanna Christina Recktenwald." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1229435891/34.

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