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Goswami, A. P., B. Prasad, and V. C. Joshi. "Characterization of finger millet [Eleusine coracana (L.) Gaertn.] germplasm for morphological parameters under field conditions." Journal of Applied and Natural Science 7, no. 2 (2015): 836–38. http://dx.doi.org/10.31018/jans.v7i2.692.
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The trial was conducted at the research block of Crop Improvement, GBPUAT, Hill Campus, Ranichauri using randomized block design (RBD) to characterize finger millet germplasm for morphological characters viz., plant height, flag leaf length, number of tiller plant-1, number of finger ear-1, ear length, no. of grain finger-1, no. of grain ear-1 and grain yield plant-1. Among all germplasms, number of finger ear-1, number of grain finger-1 and grain yield plant-1(g) had recorded highest in VL 149 which were 9.96, 150.66, 2.63 g respectively. The germplasm GEC 1406 attained lowest plant height (75.89 cm), GEC 961 had recorded higher flag leaf length (40.96 cm), GEC 268 had recorded maximum number of tiller plant-1 (3.30), GEC 199 had recorded higher ear length (9.20 cm), GEC 1044 had recorded maximum number of grain ear-1 (663) among all germplasm of finger millet. This study is helpful to identify superior germplasm so they can be used for further finger millet crop improvement programs.
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Kizyakov, Alexander, Marina Leibman, Mikhail Zimin, et al. "Gas Emission Craters and Mound-Predecessors in the North of West Siberia, Similarities and Differences." Remote Sensing 12, no. 14 (2020): 2182. http://dx.doi.org/10.3390/rs12142182.
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Detailed analysis of five gas emission craters (GEC) found in the north of West Siberia is presented. Remote sensing data used in the study is verified by field surveys. Previous studies show that all of the GECs were preceded by mounds 2 to 6 m high and 20 to 55 m in diameter. GECs initially were 20–25 m in diameter, which increased in the first years of their existence. GECs are found in various environmental (shrublands or moss-grass tundra) and geomorphic (river valley, terrace, slopes) conditions. The objective of the paper is to identify common and differing geomorphologic and environmental characteristics of all the five GEC, and their mound-predecessors. The study is based on a compilation of DSMs before and after the GEC formation using very high-resolution satellite imagery stereo pairs compared to ArcticDEM project data. Diversity of terrain and environmental settings along with rather a narrow range of GEC and mound-predecessor morphometric parameters allows concluding that the mechanism of GEC formation is most likely similar for all the GEC and is controlled rather by internal geologic and cryolithologic structure than by any surface properties.
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Hinzpeter, Ricarda, Seyed Ali Mirshahvalad, Roshini Kulanthaivelu, et al. "Gastro-Esophageal Cancer: Can Radiomic Parameters from Baseline 18F-FDG-PET/CT Predict the Development of Distant Metastatic Disease?" Diagnostics 14, no. 11 (2024): 1205. http://dx.doi.org/10.3390/diagnostics14111205.
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We aimed to determine if clinical parameters and radiomics combined with sarcopenia status derived from baseline 18F-FDG-PET/CT could predict developing metastatic disease and overall survival (OS) in gastroesophageal cancer (GEC). Patients referred for primary staging who underwent 18F-FDG-PET/CT from 2008 to 2019 were evaluated retrospectively. Overall, 243 GEC patients (mean age = 64) were enrolled. Clinical, histopathology, and sarcopenia data were obtained, and primary tumor radiomics features were extracted. For classification (early-stage vs. advanced disease), the association of the studied parameters was evaluated. Various clinical and radiomics models were developed and assessed. Accuracy and area under the curve (AUC) were calculated. For OS prediction, univariable and multivariable Cox analyses were performed. The best model included PET/CT radiomics features, clinical data, and sarcopenia score (accuracy = 80%; AUC = 88%). For OS prediction, various clinical, CT, and PET features entered the multivariable analysis. Three clinical factors (advanced disease, age ≥ 70 and ECOG ≥ 2), along with one CT-derived and one PET-derived radiomics feature, retained their significance. Overall, 18F-FDG PET/CT radiomics seems to have a potential added value in identifying GEC patients with advanced disease and may enhance the performance of baseline clinical parameters. These features may also have a prognostic value for OS, improving the decision-making for GEC patients.
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Starchenko, Vladimir, Darya Kharlamova, Elizaveta Klykova, et al. "Fighting Evaluation Inflation: Concentrated Datasets for Grammatical Error Correction Task." Journal of Language and Education 10, no. 4 (2024): 112–29. https://doi.org/10.17323/jle.2024.22272.
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Background: Grammatical error correction (GEC) systems have greatly developed over the recent decade. According to common metrics, they often reach the level of or surpass human experts. Nevertheless, they perform poorly on several kinds of errors that are effortlessly corrected by humans. Thus, reaching the resolution limit, evaluation algorithms and datasets do not allow for further enhancement of GEC systems. Purpose: To solve the problem of the resolution limit in GEC. The suggested approach is to use for evaluation concentrated datasets with a higher density of errors that are difficult for modern GEC systems to handle. Method: To test the suggested solution, we look at distant-context-sensitive errors that have been acknowledged as challenging for GEC systems. We create a concentrated dataset for English with a higher density of errors of various types, half-manually aggregating pre-annotated examples from four existing datasets and further expanding the annotation of distant-context-sensitive errors. Two GEC systems are evaluated using this dataset, including traditional scoring algorithms and a novel approach modified for longer contexts. Results: The concentrated dataset includes 1,014 examples sampled manually from FCE, CoNLL-2014, BEA-2019, and REALEC. It is annotated for types of context-sensitive errors such as pronouns, verb tense, punctuation, referential device, and linking device. GEC systems show lower scores when evaluated on the dataset with a higher density of challenging errors, compared to a random dataset with otherwise the same parameters. Conclusion: The lower scores registered on concentrated datasets confirm that they provide a way for future improvement of GEC models. The dataset can be used for further studies focusing on distant-context-sensitive GEC.
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Chen, Yuwen. "GIS-statically-based modelling the groundwater quality assessment coupled with soil and terrain attributes data." PLOS ONE 18, no. 11 (2023): e0292680. http://dx.doi.org/10.1371/journal.pone.0292680.
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In this study, we investigated the application of Geographic Information Systems (GIS) for groundwater quality assessment through the integration of statistical models with soil and topographical data. Our primary objectives were to identify soil parameters and topographical attributes contributing to groundwater quality assessment and to evaluate the potential of geostatistics and GIS for spatial analysis of groundwater resources. Groundwater samples were collected from 43 agricultural wells, and surface soil layer samples (0–20 cm) were obtained near each well. We measured groundwater quality parameters and relevant soil properties. Our approach involved the utilization of multiple linear regression (MLR) and principal component regression (PCR), combined with topographical terrain attributes and soil data, for modeling groundwater electrical conductivity (GEC). Our findings revealed significant correlations between GEC and soil electrical conductivity (EC) (r = 0.89) as well as soil carbonate (CaCO3) (r = 0.68). Among the ten topographical attributes considered, the terrain wetness index (TWI) exerted the highest influence on GEC (r = 0.57), followed by the slope (r = -0.47). Further analysis demonstrated that the MLR model outperformed the PCR model in both the development and calibration datasets, with an achieved R2value of 0.89 and a root mean square error (RMSE)of 150 μScm-1 for MLR, compared to an R2 of 0.85 and an RMSE of 170 μScm-1 for PCR when coupled with soil and attribute data for GEC prediction. The resulting GEC map generated from the MLR model displayed spatial variations, ranging from 605 μScm-1 in the northern region to 1275 μScm-1 in the central part of the study site. In conclusion, our study demonstrated the effectiveness of combining statistical modeling with geostatistics and GIS for groundwater quality assessment, providing valuable insights for resource management and environmental planning.
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Azma, Aliasghar, Esmaeil Narreie, Abouzar Shojaaddini, et al. "Statistical Modeling for Spatial Groundwater Potential Map Based on GIS Technique." Sustainability 13, no. 7 (2021): 3788. http://dx.doi.org/10.3390/su13073788.
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In arid and semi-arid lands like Iran water is scarce, and not all the wastewater can be treated. Hence, groundwater remains the primary and the principal source of water supply for human consumption. Therefore, this study attempted to spatially assess the groundwater potential in an aquifer in a semi-arid region of Iran using geographic information systems (GIS)-based statistical modeling. To this end, 75 agricultural wells across the Marvdasht Plain were sampled, and the water samples’ electrical conductivity (EC) was measured. To model the groundwater quality, multiple linear regression (MLR) and principal component regression (PCR) coupled with elven environmental parameters (soil-topographical parameters) were employed. The results showed that that soil EC (SEC) with Beta = 0.78 was selected as the most influential factor affecting groundwater EC (GEC). CaCO3 of soil samples and length-steepness (LS factor) were the second and third effective parameters. SEC with r = 0.89 and CaCO3 with r = 0.79 and LS factor with r = 0.69 were also characterized for PC1. According to performance criteria, the MLR model with R2 = 0.94, root mean square error (RMSE) = 450 µScm−1 and mean error (ME) = 125 µScm−1 provided better results in predicting the GEC. The GEC map indicated that 16% of the Marvdasht groundwater was not suitable for agriculture. It was concluded that GIS, combined with statistical methods, could predict groundwater quality in the semi-arid regions.
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Wang, Xiaoyan, Yantao Zhong, Fei Zhu, and Jiandong Huang. "Digital Industrial Design Method in Architectural Design by Machine Learning Optimization: Towards Sustainable Construction Practices of Geopolymer Concrete." Buildings 14, no. 12 (2024): 3998. https://doi.org/10.3390/buildings14123998.
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The construction industry’s evolution towards sustainability necessitates the adoption of environmentally friendly materials and practices. Geopolymer concrete (GeC) stands out as a promising alternative to conventional concrete due to its reduced carbon footprint and potential for cost savings. This study explores the predictive capabilities of soft computing models in estimating the compressive strength of GeC, utilizing multi-layer perceptron (MLP) neural networks and hybrid systems incorporating the Gannet Optimization Algorithm (GOA) and Grey Wolf Optimizer (GWO). A dataset comprising 63 observations from a quarry mine in Malaysia is employed, with influential parameters normalized and utilized for model development. Consequently, we integrate optimization algorithms (GOA and GWO) with MLP to fine-tune the model’s parameters and improve prediction accuracy. The models are evaluated using R2, RMSE, and VAF. Various MLP architectures are explored, evaluating transfer functions and training techniques to optimize performance. In addition, hybrid models GOA–MLP and GWO–MLP are developed, with parameters fine-tuned to enhance predictive accuracy. During the training phase, the GWO–MLP model achieved an R2 of 0.981, RMSE of 0.962, and VAF of 97.44%, compared to MLP’s R2 of 0.95, RMSE of 0.918, and VAF of 94.59%. During the testing phase, GWO–MLP also showed the best performance with an R2 of 0.976, RMSE of 1.432, and VAF of 97.51%, outperforming both MLP and GOA–MLP. The GOA–MLP model demonstrated improved performance over MLP with an R2 of 0.963, RMSE of 0.811, and VAF of 95.78% in the training phase and R2 of 0.944, RMSE of 2.249, and VAF of 92.86% in the testing phase. Hence, the results show that the GWO–MLP model consistently outperforms both MLP and GOA–MLP models. Sensitivity analysis further elucidates the impact of key parameters on compressive strength, aiding in the optimization of GeC formulations for enhanced mechanical properties. Overall, the study underscores the efficacy of machine learning models in predicting GeC compressive strength, offering insights for sustainable construction practices.
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Mohrman, D. E., and L. J. Heller. "Transcapillary adenosine transport in isolated guinea pig and rat hearts." American Journal of Physiology-Heart and Circulatory Physiology 259, no. 3 (1990): H772—H783. http://dx.doi.org/10.1152/ajpheart.1990.259.3.h772.
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Transcapillary adenosine transport was studied in isolated guinea pig and rat hearts perfused with a colloid-free solution. High-performance liquid chromatography techniques were used to measure adenosine concentration of venous and interstitial (epicardial surface) fluid during steady-state perfusion with various concentrations of adenosine. A mathematical model was used to analyze these data to obtain estimates of the following parameters of transcapillary adenosine transport: PSg, permeability-surface area product for adenosine movement through interendothelial cell channels; PSecl, permeability-surface area product for adenosine movement through the luminal plasma membrane of endothelial cells; and Gec, clearance rate constant for endothelial cell metabolism and/or sequestration of adenosine. In both guinea pig and rat hearts, PSg was estimated to be less than or equal to 3 ml.min-1.g-1. Estimates of PSecl and Gec of guinea pig hearts (7.2 +/- 0.4 and 230 +/- 157 ml.min-1.g-1) were significantly less than those of rat hearts (66 +/- 11 and 2,490 +/- 1,360 ml.min-1.g-1). That PSecl is greater than PSg in both species indicates that endothelial cells represent an important pathway for transcapillary adenosine transport. That Gec is much greater than PSecl in both species implies that endothelial cells act as a sink for adenosine from surrounding areas. Our results indicate that endothelium is a stronger sink for adenosine in rat hearts than in guinea pig hearts. Inosine infusion (10(-4)M) had little effect on the estimated PSecl and Gec in guinea pig hearts but reduced these parameters several-fold in rat hearts, suggesting that different transport mechanisms for adenosine exist in endothelia of guinea pig and rat hearts.
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Park, Chanjun, Seonmin Koo, Gyeongmin Kim, and Heuiseok Lim. "Towards Harnessing the Most of ChatGPT for Korean Grammatical Error Correction." Applied Sciences 14, no. 8 (2024): 3195. http://dx.doi.org/10.3390/app14083195.
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In this study, we conduct a pioneering and comprehensive examination of ChatGPT’s (GPT-3.5 Turbo) capabilities within the realm of Korean Grammatical Error Correction (K-GEC). Given the Korean language’s agglutinative nature and its rich linguistic intricacies, the task of accurately correcting errors while preserving Korean-specific sentiments is notably challenging. Utilizing a systematic categorization of Korean grammatical errors, we delve into a meticulous, case-specific analysis to identify the strengths and limitations of a ChatGPT-based correction system. We also critically assess influential parameters like temperature and specific error criteria, illuminating potential strategies to enhance ChatGPT’s efficacy in K-GEC tasks. Our findings offer valuable contributions to the expanding domain of NLP research centered on the Korean language.
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Schadewaldt, Peter, Bernd Schommartz, Gregor Wienrich, Herbert Brösicke, Ralf Piolot, and Dan Ziegler. "Application of isotope-selective nondispersive infrared spectrometry (IRIS) for evaluation of [13C]octanoic acid gastric-emptying breath tests: comparison with isotope ratio–mass spectrometry (IRMS)." Clinical Chemistry 43, no. 3 (1997): 518–22. http://dx.doi.org/10.1093/clinchem/43.3.518.
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Abstract Suitability of isotope-selective nondispersive infrared spectrometry (IRIS) for evaluation of [13C]octanoic acid gastric-emptying breath test was assessed and compared with standard isotope ratio–mass spectrometry (IRMS). The estimated bias of IRMS and IRIS measurements of baseline-corrected 13CO2exhalation amounted to ± 0.1 and ± 0.6 Δδ values (n = 360), respectively. In breath tests performed on 60 diabetic patients, the gastric emptying parameters were calculated by nonlinear regression analysis of the time course of 13CO2exhalation: half-emptying time (t1/2,breath, 90 ± 39 min), lag phase (tlag,breath, 34 ± 27 min), and gastric emptying coefficient (GEC, 2.9 ± 0.5). A reasonable linear correlation was found between the two methods (y = IRIS, x = IRMS) with respect to Δδ values (y = 0.35 + 0.92x, r = 0.985, Sy|x = ±0.6, n = 1116) and a rather good agreement of the computed gastric emptying parameters was obtained (t1/2,breath: y = 0.99x + 4.06, Sy|x = ±6.3; tlag,breath: y = 0.97x + 0.96, Sy|x = ±3.4; GEC: y = 0.97x − 0.01, Sy|x = ±0.09).
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Chmielewska, Iwona. "Determination of Mechanical Properties of Soils Based on CPTU Data." Architecture, Civil Engineering, Environment 16, no. 3 (2023): 55–64. http://dx.doi.org/10.2478/acee-2023-0033.
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Abstract The study aimed to interpret the results of cone penetration tests with pore pressure measurement (CPTU). Tests were performed on a section of the designed road about 200 m long. The subsoil under consideration was characterized by organic soils deposited to a depth of approximately 8 m. Due to the problematic soil and water conditions, improvement with geosynthetic encased columns (GEC) was performed. According to the Recommendations for Design and Analysis of Earth Structures using Geosynthetic Reinforcements – EBGEO, the constrained modulus Eoed and effective friction angle φ’ of soil below the GEC column base should be higher than 5 MPa (Eoed > 5 MPa) and 30° (φ’ > 30°), respectively. In this study, the Eoed and φ’ parameters were determined based on CPTU tests conducted in 12 locations. Analysis of the CPTU data showed that the constrained modulus and effective friction angle of the soil deposited below the GEC column base did not meet EBGEO requirements in most locations. It was also concluded that the minimum value of the constrained modulus required by EBGEO is too low compared with the requested value of the effective friction angle.
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Schoennemann, Katrine Rahbek, Mette K. N. Yilmaz, Jon Kroll Bjerregaard, et al. "Cetuximab in combination with irinotecan as second-line treatment in patients with platinum-resistant gastroesophageal cancer (GEC)." Journal of Clinical Oncology 30, no. 4_suppl (2012): 101. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.101.
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101 Background: Inspired by the promising results seen in patients (pts) with chemo-resistant metastatic colorectal cancer we evaluated a biweekly schedule of cetuximab (cet) and irinotecan (iri) (Cetiri) (Pfeiffer et al. Ann Oncol 2008) in platinum resistant GEC. Methods: We treated and evaluated 111 consecutive pts with histological verified GEC adenocarcinoma and documented failure to first-line platinum-based treatment. Pts received cet 500 mg/m2 and iri 180 mg/m2 day 1 every 2nd week until progression or unacceptable toxicity. Toxicity was evaluated according to NCI-CTCAE v. 3.0. Response rate (RR) was evaluated according to RECIST v. 1.0 every 8th week. Clinical parameters and blood samples at baseline were analyzed in order to find prognostic and predictive values for prolonged overall survival (OS). Results: Pts were included from December 2007 to August 2010. Median age was 61 years (range 33-80). Performance status (PS) was 0-1 in 95 % of the pts. Thirty-six (46%) pts had more than two organs involved. Median number of courses was 8 (1-46). RR was 14% (2 CR, 13 PR) and 63% had stable disease for at least 2 months. Median PFS and OS were 3.2 months (CI 2-4) and 5.6 months (CI: 5-7) respectively. Seventy six (68%) pts had treatment induced skin toxicity, rash. In a univariate analysis PS 0-1, normal baseline haematology and skin rash was associated with significantly increased survival. These parameters retained significance in a multivariate analysis. One patient had a curative resection after end of treatment and four pts are still alive. Conclusions: Biweekly Cetiri is a convenient and well-tolerated second-line (SL) regimen in pts with GEC adenocarcinoma. Good performance status, normal baseline and development of skin rash indicate increased survival. Based on our findings biweekly Cetiri can be recommended as SL treatment to GEC pts in a good PS. Further studies into the role of rash are warranted.
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Schønnemann, Katrine Rahbek, Jon Kroll Bjerregaard, Mette K. N. Yilmaz, et al. "Biweekly cetuximab in combination with irinotecan as second-line treatment in patients with platinum-resistant gastroesophageal cancer (GEC)." Journal of Clinical Oncology 30, no. 15_suppl (2012): e14517-e14517. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e14517.
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e14517 Background: Inspired by the promising results seen in patients (pts) with chemo-resistant metastatic colorectal cancer we evaluated a biweekly schedule of cetuximab (cet) and irinotecan (iri) - (Cetiri) (Pfeiffer et al. Ann Oncol 2008) in platinum resistant GEC. Methods: We treated and evaluated 111 consecutive pts with histological verified GEC adenocarcinoma and documented failure to first-line platinum-based treatment. Pts received cet 500 mg/m2 and iri 180 mg/m2 day 1 every 2nd week until progression or unacceptable toxicity. Toxicity was evaluated according to NCI-CTCAE v. 3.0. Response rate (RR) was evaluated according to RECIST v. 1.0 every 8th week. Clinical parameters and blood samples at baseline were analyzed in order to find prognostic and predictive values for prolonged overall survival (OS). Results: Pts were included from December 2007 to August 2010. Median age was 63 years (range 33-81). Performance status (PS) was 0-1 in 95 % of the pts. Thirty-six (46%) pts had more than two organs involved. Median number of courses were 5 (1-46). RR was 13% (13 PR) and 48 % had stable disease for at least 2 months. Median PFS and OS were 3.3 months (CI 2-4) and 5.6 months (CI: 5-7) respectively. Seventy six (68%) pts had treatment induced skin toxicity, rash. In a univariate analysis PS 0-1, normal baseline haematology and skin rash was associated with significantly increased survival. These parameters retained significance in a multivariate analysis. One patient had a curative intended resection after 28 courses and had an overall survival at 29.5 months. Two pts are still alive. Conclusions: Biweekly Cetiri is a convenient and well-tolerated second-line (SL) regimen in pts with GEC adenocarcinoma. Good PS, normal baseline haematology and development of skin rash indicate increased survival. Based on our findings biweekly Cetiri can be recommended as SL treatment to GEC pts in a good PS. Further studies into the role of rash are warranted.
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Baumgaertner, A. J. G., G. M. Lucas, J. P. Thayer, and S. A. Mallios. "On the role of non-electrified clouds in the Global Electric Circuit." Atmospheric Chemistry and Physics Discussions 14, no. 7 (2014): 9815–47. http://dx.doi.org/10.5194/acpd-14-9815-2014.
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Abstract. Non-electrified clouds in the fair-weather part of the Global Electric Circuit (GEC) reduce conductivity because of the limited mobility of charge due to attachment to cloud water droplets, effectively leading to a loss of ions. A high-resolution GEC model, which numerically solves the Poisson equation, is used to show that in the fair-weather region currents partially flow around non-electrified clouds, with current divergence above the cloud, and convergence below the cloud. An analysis of this effect is presented for various types of non-electrified clouds, i.e. for different altitude extents, and for different horizontal dimensions, finding that the effect is most pronounced for high clouds with a diameter below 100 km. Based on these results, a method to calculate column and global resistance is developed that can account for all cloud sizes and altitudes. The CESM1(WACCM) Earth System Model as well as ISCCP cloud data are used to calculate the effect of this phenomenon on global resistance. From CESM1(WACCM), it is found that when including non-electrified clouds in the fair-weather estimate of resistance the global resistance increases by up to 73%, depending on the parameters used. Using ISCCP cloud cover leads to an even larger increase, which is likely to be overestimated because of time-averaging of cloud cover. Neglecting current divergence/convergence around small clouds overestimates global resistance by up to 20%, whereas the method introduced by previous studies underestimates global resistance by up to 40%. For global GEC models, a conductivity parametrization is developed to account for the current divergence/convergence phenomenon around non-electrified clouds. Conductivity simulations from CESM1(WACCM) using this parametrization are presented.
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Baumgaertner, A. J. G., G. M. Lucas, J. P. Thayer, and S. A. Mallios. "On the role of clouds in the fair weather part of the global electric circuit." Atmospheric Chemistry and Physics 14, no. 16 (2014): 8599–610. http://dx.doi.org/10.5194/acp-14-8599-2014.
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Abstract. Clouds in the fair weather return path of the global electric circuit (GEC) reduce conductivity because of the limited mobility of charge due to attachment to cloud water droplets, effectively leading to a loss of ions. A high-resolution GEC model, which numerically solves the current continuity equation in combination with Ohm's law, is used to show that return currents partially flow around clouds, with current divergence above the cloud and convergence below the cloud. An analysis of this effect is presented for various types of clouds, i.e., for different altitude extents and for different horizontal dimensions, finding that the effect is most pronounced for high clouds with a diameter below 100 km. Based on these results, a method to calculate column and global resistance is developed that can account for all cloud sizes and altitudes. The CESM1(WACCM) (Community Earth System Model – Whole Atmosphere Community Climate Model) as well as ISCCP (International Satellite Cloud Climatology Project) cloud data are used to calculate the effect of this phenomenon on global resistance. From CESM1(WACCM), it is found that when including clouds in the estimate of resistance the global resistance increases by up to 73%, depending on the parameters used. Using ISCCP cloud cover leads to an even larger increase, which is likely to be overestimated because of time averaging of cloud cover. Neglecting current divergence/convergence around small clouds overestimates global resistance by up to 20% whereas the method introduced by previous studies underestimates global resistance by up to 40%. For global GEC models, a~conductivity parameterization is developed to account for the current divergence/convergence phenomenon around clouds. Conductivity simulations from CESM1(WACCM) using this parameterization are presented.
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ЗАЙНЕТДИНОВ, Б. Г., В. Н. МОРОЗОВ, and В. В. ЗАНЮКОВ. "The influence of aerosol on elements of global atmospheric electrical circuit." Optika atmosfery i okeana 37, no. 5(424) (2024): 409–14. http://dx.doi.org/10.15372/aoo20240508.
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Одной из важных проблем в теории атмосферного электричества является исследование влияния аэрозольных частиц на параметры токовой цепи в атмосфере, или на глобальную токовую цепь. Представлена теоретическая модель влияния аэрозольных частиц в областях хорошей погоды на глобальную электрическую цепь (ГЭЦ) в атмосфере. Аэрозоль в приземном слое атмосферы рассматривается как слагаемое, входящее в полное сопротивление столба атмосферы. При этом генераторы электрического поля, поддерживающие ГЭЦ, не учитываются, а входят через граничное условие на верхней границе ионосферы в виде задания величины потенциала ионосферы. Также представлены результаты экспериментальных наблюдений за электрическими характеристиками атмосферы и концентрацией аэрозольных частиц. Теоретические и экспериментальные исследования дают возможность оценить концентрацию аэрозольных частиц субмикронного диапазона. The influence of aerosol particles on the parameters of the global atmospheric electrical circuit is among important issues of the theory of atmospheric electricity. This paper presents a theoretical model of the effect of aerosol particles on the global atmospheric electrical circuit (GEC) under the fair weather. Surface aerosol is considered as a summand in the total atmospheric columnar resistance. Electric field generators which support the GEC are taken into account through the boundary condition as specified ionospheric potential. In addition to the theoretical model, experimental observations of electrical characteristics of the atmosphere and of the aerosol concentration are presented. The theoretical and experimental studies make it possible to estimate the concentration of submicron aerosol particles.
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Grothey, Axel, Amber Fifield, Kieran Sweeney, et al. "Abstract 496: Clinical, biologic, and immunogenic characteristics of gastro-esophageal cancers (GEC) harboring CLDN18::ARHGAP fusions." Cancer Research 85, no. 8_Supplement_1 (2025): 496. https://doi.org/10.1158/1538-7445.am2025-496.
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Abstract Background: Claudin 18.2 (CLDN18.2) overexpression has recently emerged as a therapeutic target in advanced gastro-esophageal cancer (GEC). CLDN18::ARHGAP fusions are pathognomonic for GEC, but their biologic relevance in this malignancy is poorly understood. We analyzed the correlation of CLDN18::ARHGAP fusions with other molecular parameters, tumor microenvironment (TME) parameters, patient characteristics, and outcomes data in a large clinico-genomic database. Methods: DNA and RNA (whole transcriptome) sequencing was performed for patient tumor samples submitted to Caris Life Sciences. CLDN18::ARHGAP fusions were identified from RNA transcripts. PD-L1 (28-8) and CLDN18 (43-14A) protein levels were determined by immunohistochemistry (IHC). TMB-High (TMB-H) was defined as ≥10 mutations/Mb. Significance was tested using Mann-Whitney, Fisher’s Exact, or Chi-squared tests with multiple comparisons correction applied as appropriate. TME cell fractions were estimated by RNA deconvolution using quanTIseq. Real-world overall survival (OS) and nivolumab time on treatment (ToT) were obtained from insurance claims data and calculated from collection date to time of last contact and first of nivolumab to last of nivolumab, respectively; associated hazard ratios (HR) and p-values were calculated using the Cox proportional hazard model. Results: Among 4430 GEC tumors, 262 tumors (6.1%) harbored a CLDN18::ARHGAP fusion, primarily CLDN18::ARHGAP26 (N=226). Patients with fusion+ tumors were younger (median age: 58 vs 66 years, p<0.0001) and more frequently female (64.1% vs 41.1%, p<0.0001). Fusion+ tumors had more frequent HER2 (9.7% vs 3.4%, p<0.0001) and HER3 (10.5% vs 3.8% p<0.0001) mutations and less frequent RHOA (0% vs 7.5%, p=0.0009), CDH1(3.9% vs 20.4%, p<0.0001), and KRAS (2.7% vs 10.0%, p=0.0033) mutations. Fusion+ tumors had a lower prevalence of the IO-related biomarkers TMB-H (4.8% vs 13.9%, p=0.0030), dMMR/MSI-H (3.9% vs 9.5%, p=0.0416), and PD-L1+ (12.5% vs 32.5%, p=0.0001), lower infiltration of CD8+ T cells (0% vs 0.2%, p=0.0016) and M1 macrophages (3.0% vs 3.9%, p<0.0001), and higher infiltration of M2 macrophages (5.4% vs 3.9%, p<0.0001). Using either standard (≥2+, ≥75%) or reduced (≥2+, ≥40%) IHC cut-offs, fusion+ tumors were more frequently CLDN18 IHC+ than fusion- tumors (79.5% vs 47.9%, p<0.0001 and 86.4% vs 54.5%, p<0.0001, respectively). Comparing fusion+ vs fusion- cancers, there was no significant difference in median OS (15.6 vs 13.6 months; HR=0.892, p=0.1986) or nivolumab ToT (7.4 vs 4.8 months, HR=0.751, p=0.1359). Conclusions: CLDN18::ARHGAP fusions characterize GECs with distinct clinical and biologic features that suggest lower immunogenicity. Fusions were positively correlated with a higher CLDN18 protein expression Citation Format: Axel Grothey, Amber Fifield, Kieran Sweeney, Heinz-Josef Lenz, Matthew Oberley, Sanjay Goel, Shuanzeng Wei, Andrew Elliott, Bradley Somer. Clinical, biologic, and immunogenic characteristics of gastro-esophageal cancers (GEC) harboring CLDN18::ARHGAP fusions [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 496.
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Rajole, Sangamesh, K. S. Ravishankar, and S. M. Kulkarni. "Study on Ballistic Energy Absorption Capability of Glass-Epoxy and Jute-Epoxy-Rubber Sandwich Composites." Materials Science Forum 928 (August 2018): 14–19. http://dx.doi.org/10.4028/www.scientific.net/msf.928.14.
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High velocity impact analysis of natural fiber reinforced composites is essential as the trend is focused towards the development of light weight, environment-friendly, non-corrosive and economical materials. At present, the defence, aerospace and automobile sectors are using synthetic fiber composites which are expensive and non-eco-friendly. In the present study ballistic impact of jute-epoxy (JEC), glass-epoxy (GEC), jute-epoxy-rubber (JERC) sandwich composites are simulated with different thickness (1, 2 and 3 mm) and velocity variations (100, 200 and 300m/s) using Finite Element analysis software. Although different approaches to the analysis of the effect response of composite structures are available, numerical modeling is based on strict constitutive models is often preferred because it can provide valuable detailed information about the spatial and temporal distribution of damage during the impact. The ballistic parameters such as energy absorption, ballistic limit and fracture behaviors are predicted. The composite is made of 8 noded linear brick elements and the bullet/projectile is modeled as a discrete rigid element in which deformation behavior, energy absorption and penetration behaviors obtained are clearly represented. The simulation results predicted match well with the analytical results obtained. Among all the combination of the materials simulated, the sandwiches have better ballistic qualities. Energy absorption of sandwich (JERC) was found 67 percentage higher than GEC and 56 percentage higher than JEC laminate. In future, these materials can be the alternative materials for defence sector for bullet proofing.
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Gulyaeva, Tamara, Manuel Hernández-Pajares, and Iwona Stanislawska. "Ionospheric Weather at Two Starlink Launches during Two-Phase Geomagnetic Storms." Sensors 23, no. 15 (2023): 7005. http://dx.doi.org/10.3390/s23157005.
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The launch of a series of Starlink internet satellites on 3 February 2022 (S-36), and 7 July 2022 (S-49), coincided with the development of two-phase geomagnetic storms. The first launch S-36 took place in the middle of the moderate two-phase space weather storm, which induced significant technological consequences. After liftoff on 3 February at 18:13 UT, all Starlink satellites reached an initial altitude of 350 km in perigee and had to reach an altitude of ~550 km after the maneuver. However, 38 of 49 launched spacecrafts did not reach the planned altitude, left orbit due to increased drag and reentered the atmosphere on 8 February. A geomagnetic storm on 3–4 February 2022 has increased the density of the neutral atmosphere up to 50%, increasing drag of the satellites and dooming most of them. The second launch of S-49 at 13:11 UT on 7 July 2022 was successful at the peak of the two-phase geomagnetic storm. The global ionospheric maps of the total electron content (GIM-TEC) have been used to produce the ionospheric weather GIM-W index maps and Global Electron Content (GEC). We observed a GEC increment from 10 to 24% for the storm peak after the Starlink launch at both storms, accompanying the neutral density increase identified earlier. GIM-TEC maps are available with a lag (delay) of 1–2 days (real-time GIMs have a lag less than 15 min), so the GIMs forecast is required by the time of the launch. Comparisons of different GIMs forecast techniques are provided including the Center for Orbit Determination in Europe (CODE), Beijing (BADG and CASG) and IZMIRAN (JPRG) 1- and 2-day forecasts, and the Universitat Politecnica de Catalunya (UPC-ionSAT) forecast for 6, 12, 18, 24 and 48 h in advance. We present the results of the analysis of evolution of the ionospheric parameters during both events. The poor correspondence between observed and predicted GIM-TEC and GEC confirms an urgent need for the industry–science awareness of now-casting/forecasting/accessibility of GIM-TECs during the space weather events.
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Chen, Ting, Yanan Zheng, Lorin Roskos, and Donald E. Mager. "Predicting overall survival (OS) and overall response (OR) following durvalumab treatment in patients with multiple cancer types using a hybrid modeling strategy." Journal of Clinical Oncology 38, no. 15_suppl (2020): e15161-e15161. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e15161.
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e15161 Background: This study aimed to predict OS/OR and identify key predictors in patients with diverse cancer types treated with durvalumab, a PD-L1 targeting monoclonal antibody, using a hybrid modeling strategy that combines population pharmacodynamic (PD) modeling and machine learning (ML) algorithms. Methods: Individual longitudinal tumor size measurements and OS/OR data were available for 855 patients who received durvalumab therapy (10 mg/kg Q2W or 20 mg/kg Q4W; NCT01693562). Nine cancer types included non-small cell lung cancer (NSCLC), bladder cancer (BC), microsatellite instability-high (MSI-H) cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma of the head and neck (SCCHN), gastroesophageal cancer (GEC), ovarian cancer (OC), pancreatic adenocarcinoma (PDAC) and triple-negative breast cancer (TNBC). A tumor kinetic model was developed to characterize diverse temporal profiles using a population-based modeling approach. Individual estimated tumor kinetic model parameters and patient demographic/physiological factors were used as inputs for predicting OS/OR using several ML approaches. Results: The final tumor kinetic model with liver metastasis (LM), neutrophil/lymphocyte ratio (NLR), tumor size at baseline (TBSL) and cancer types as covariates characterized the temporal tumor size data well. HCC and MSI-H cancer have the slowest tumor growth rate constant (kg), while GEC, SCCHN and TNBC have the fastest kg. BC, NSCLC and OC have the highest tumor killing rate constant. The most important predictors of OS identified by ML approach were tumor kinetic parameters (kg, fraction of drug-sensitive cells, time-delay in immune response), along with baseline disease factors, including hemoglobin (HGBBL), albumin (ALB), and NLR. Decision tree-based algorithms showed the best performance in predicting OR with accuracy above 90%. In addition to tumor kinetic parameters, PD-L1 expression on tumor cells (TC) and ALB were the most important predictors of OR. Conclusions: A combined population PD/ML approach showed good predictions of OS/OR in patients with different cancer types treated with durvalumab. LM, NLR,TBSL and cancer types were found to be important factors for tumor kinetics. In addition to tumor kinetic parameters, HGBBL, ALB, and NLR were found to be important predictors of OS, and TC and ALB were found to be important predictors of OR. These findings could provide a guidance on patient selection in future clinical trials.
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Zoita, C. N., C. E. A. Grigorescu, I. C. Vasiliu, and I. D. Feraru. "Influence of process parameters on structure and optical properties of GeC thin films deposited by RF magnetron sputtering." Thin Solid Films 519, no. 12 (2011): 4101–4. http://dx.doi.org/10.1016/j.tsf.2011.01.204.
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Hadi, M. A., M. Roknuzzaman, F. Parvin, S. H. Naqib, A. K. M. A. Islam, and M. Aftabuzzaman. "New MAX Phase Superconductor Ti2GeC: A First-principles Study." Journal of Scientific Research 6, no. 1 (2013): 11–27. http://dx.doi.org/10.3329/jsr.v6i1.16604.
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This is the first DFT-based first-principles prediction of the detailed optical and thermodynamic properties, including Vickers hardness and Fermi surface of 211 MAX phase Ti2GeC for which superconductivity (Tc~ 9.5 K) was reported very recently. The calculated structural properties are in excellent agreement with experiments. Our results on elastic parameters indicate a slight elastic anisotropy and brittleness of the compound. The chemical bonding is seen to be a combination of covalent, ionic and metallic nature. The rather stronger covalent bonding is responsible for its high Vickers hardness of 11.6 GPa. The investigated Fermi surface is formed mainly by the low-dispersive bands, which should be responsible for the presence of superconductivity in Ti2GeC. All the optical properties are evaluated and analyzed for two different polarization directions of incident photon. The temperature and pressure dependence of primitive cell volume, thermal expansion coefficient, specific heats, bulk modulus, and Debye temperature of Ti2GeC are derived from the quasi-harmonic Debye model with phononic effect and the various implications are discussed in details. Keywords: First-principles calculation; Vickers hardness; Optical properties; Thermodynamic properties. © 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. doi: http://dx.doi.org/10.3329/jsr.v6i1.16604 J. Sci. Res. 6 (1), 11-27 (2014)
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Betiku, Anthony O., Adeola O. Onakoya, Olufisayo T. Aribaba, and Omodele O. Jagun. "Relationship between axial length, keratometry and central corneal thickness in patients with refractive errors at a teaching hospital in Southwest, Nigeria." International Journal of Advances in Medicine 8, no. 11 (2021): 1657. http://dx.doi.org/10.18203/2349-3933.ijam20214128.
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Background: Aim of the study was to determine the relationship between axial length (AL), keratometry and central corneal thickness (CCT), and refractive errors in adult patients attending the Guinness eye centre (GEC), Lagos university teaching hospital (LUTH) Idi-Araba, Lagos.Methods: A descriptive cross-sectional study conducted among consecutive patients aged 16 years and above with refractive errors attending the GEC, LUTH. Ocular parameters measured included AL, anterior corneal curvature, CCT and refractive errors. AL and keratometry were measured with IOL master and CCT with ultrasonic A scan pachymeter. Refraction was done with auto-refractor-keratometer. Data analysis was done with statistical package for social science (SPSS) 20. Results: A total of 394 patients were studied, 157 males and 237 females. The age range was 16-65 years, mean -37.9±13.3 years and median -36.5 years. There were more myopic patients 215 (54.6%) than hyper-metropes 179 (45.4%). The mean AL was 23.9±1.1 mm and eyes with longer AL were more likely to be myopic (r=-0.676, p<0.001); to have flatter cornea (r=0.519, p<0.001) and thicker cornea (r=0.149, p=0.003). The mean CCT was 520.3±31.0 µm. There was a weak negative correlation between CCT and refractive error (r=-0.111, p=0.027).Conclusions: The mean CCT was lower than the mean CCT of other Nigerian studies. Hypermetropic patients were more likely to have thinner corneas. This may lead to underestimation of intraocular pressure (IOP) in these patients. Significant correlation was seen between AL and refractive error, CCT and keratometry. AL correlated with less spherical equivalent refractive error, flatter and thicker cornea. It is therefore important to measure the CCT of all patients going for refractive surgery to detect those at risk of developing corneal ectasia following refractive surgery.
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Jagtap, V., A. Mawlong, U. Mahantshetty, et al. "634 poster CT IMAGE BASED DOSIMETRIC EVALUATION OF GYN GEC-ESTRO DVH PARAMETERS FOR HDR BRACHYTHERAPY IN CERVICAL CANCERS." Radiotherapy and Oncology 99 (May 2011): S258. http://dx.doi.org/10.1016/s0167-8140(11)70756-3.
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MAHMOOD, A., L. E. SANSORES, and J. HEIRAS. "BULK MODULUS CALCULATIONS FOR GROUP-IV CARBIDES AND GROUP-III NITRIDES." Modern Physics Letters B 18, no. 24 (2004): 1247–54. http://dx.doi.org/10.1142/s0217984904007736.
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Wide band gap semiconductors such as group-IV carbides ( SiC , GeC ) and group-III nitrides ( AlN , GaN and BN ) are known to be important materials for novel semiconductor applications. They also have interesting mechanical properties such as having a particularly high value for their bulk modulus and are therefore potential candidates for hard coatings. In this paper we report the theoretical calculations for the bulk modulus for zincblende and wurzite polytypes of these materials. The Density Functional and Total-energy Pseudopotential Techniques in the Generalized Gradient approximation, an ab initio quantum mechanical method, is used to obtain the theoretical structure, from which equilibrium lattice parameters and volume of the cell versus pressure may be extracted. The Murnaghan's equation of state is then used to calculate bulk modulus under elastic deformation, which is related to the hardness of a material under certain conditions. The results for bulk modulus are compared with other theoretical and experimental values reported in the literature.
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Chi, Alexander, Mingcheng Gao, and Kevin Albuquerque. "3D-image-based treatment planning for gynecological interstitial brachytherapy (IB) with GEC-ESTRO Working Group recommended dose volume parameters: Initial experience." Brachytherapy 6, no. 2 (2007): 88. http://dx.doi.org/10.1016/j.brachy.2007.02.071.
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Pompos, Arnold, Benjamin Shahabi-Azad, Michael Speiser, Abel Moron, Jayanthi Lea, and Kevin Albuquerque. "Correlation of Severe (Grade 3-4) Late Recto-Sigmoid and Bladder Toxicity in Archival Patients with GEC-ESTRO OAR Dose-Volume Parameters." Brachytherapy 12 (March 2013): S50. http://dx.doi.org/10.1016/j.brachy.2013.01.097.
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Li, Jin, Chenchen Wang, Qin Su, et al. "The prognostic significance of MET overexpression in Chinese patients with gastric adenocarcinoma." Journal of Clinical Oncology 32, no. 3_suppl (2014): 53. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.53.
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53 Background: MET, receptor for hepatocyte growth factor (HGF), has been proposed as a therapeutic target in gastroesophageal cancer (GEC). The purpose of this study was to evaluate MET expression in Chinese patients with resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma and to correlate expression with clinicopathologic parameters and prognosis. Methods: MET protein expression was assessed by immunohistochemistry (IHC) in paraffin-embedded tissues from resected tumor specimens. MET IHC was conducted using the CONFIRM SP44 anti-MET monoclonal antibody (Ventana Medical Systems Inc., Tucson, AZ). Four MET IHC scores were defined: 3+ (≥50% of tumor cells staining with strong intensity); 2+ (≥50% of tumor cells with moderate or higher staining, but <50% with strong intensity); 1+ (≥50% of tumor cells with weak or higher staining, but <50% with moderate or higher intensity); or 0 (no staining, or <50% of tumor cells with any intensity) (Spigel et al, J Clin Oncol 2011;29:Suppl, Abst 7505). Kaplan-Meier was used to estimate OS and differences between MET subgroups were compared using the log-rank test. Univariate survival analysis was performed using the stratified Cox model. Results: 442 resected gastric adenocarcinoma samples were collected from patients who underwent surgery between Sept 2007 and Feb 2010. After excluding patients with missing survival, MET, tumor location, differentiation status and stage data, 362 samples were analyzed. Stage II and III accounted for 23% and 59%, respectively. MET prevalence by IHC was: 3+, 5.5%; 2+, 19.6%; 1+, 37.0%; 0, 37.9%. At the OS cut-off, 15 Apr 2012, median follow-up was 35.3 months (range 5.9–49.8 months). The group with MET IHC scores of 2+ or 3+ had significantly shorter OS compared to those with scores of 0 or 1+. The 2-year survival rate was 64% in the 2+/3+ group and 73% in the 0/1+ group (p=0.047). The HR for MET 2+/3+ versus 0/1+ was 1.65 (95% CI: 1.13–2.39, p=0.009), stratified by stage, tumor location and differentiation status. Conclusions: MET expression in resected tissue from Chinese patients with GEC was correlated with poor prognosis. This finding further supports the development of anti-MET agents in this patient population.
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Falsetti, P., E. Conticini, C. Baldi, et al. "POS0963 POWER AND SPECTRAL DOPPLER ULTRASOUND AS A SCREENING TOOL IN THE DIAGNOSTIC COURSE OF SUSPECTED AXIAL SPONDYLOARTHRITIS: PRELIMINARY DATA FROM A LARGE MONOCENTRIC COHORT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 746.2–747. http://dx.doi.org/10.1136/annrheumdis-2021-eular.998.
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Background:Sacroiliac joints (SIJs) involvement is a characteristic feature of Spondylarthritis (SpA). Magnetic resonance imaging (MRI) has been included in the new Assessment of SpA International Society (ASAS) criteria for the classification of non-radiographic axial SpA. Power Doppler ultrasound (PDUS) and spectral Doppler US have been used in few works, also from our group, to evaluate the inflammatory activity of the SIJs, in comparison with MRI, with different results.Objectives:We aimed to evaluate the value of PDUS with spectral wave analysis (SWA) in the assessment of suspected active sacroiliitis (SI). PDUS of SIJs was used as a screening tool alongside the routine PDUS assessment of peripheral joints.Methods:143 patients (114 females and 29 males, mean age 46,2 years, mean BMI 25.9) with new onset of inflammatory back pain (IBP), were included. Peripheral symptoms were allowed. Every patient underwent a PDUS examination of SIJs as previously reported. The sonographer was blinded to the clinical data. An Esaote Twice US machine, with convex 1-8 MHz and linear 6-18 MHz probes, was used, with standardized parameters. PD signals detected in the SIJs, were scored with a 3-points scale: 0= absence of signals, 1= isolate vessels, 2= more than one vessel. The signals were also classified as intra-articular (vascularity from deep joint and inter-osseous ligament) or peri-articular (vascularity along posterior sacroiliac ligament). SWA was applied to the same vessels calculating the Resistive Index (RI) (Figure 1). A PDUS diagnosis of active SI was made with a grade 1 of vascularity and RI<0,60, or grade 2 of vascularity and RI<0,70. PDUS multi-site examination of peripheral joints and entheses was also performed; entheseal involvement was scored with Belgrade Ultrasound Enthesitis Score (BUSES) and as global enthesitic charge (GEC). Every patient underwent MRI of SIJs within 2 weeks, and before to start pharmacologic treatment. The non-parametric Spearman rank test and univariate linear regression analysis was applied using InStat GraphPad statistical package.Results:A time of 5-8 minutes was sufficient to set and to complete PDUS/SWA examination on both SJJs. All patients considered this examination quick, not painful and substantially comfortable. PD signals were detected in 124 patients (mean RI 0,56). Bone marrow edema (BME) lesions (active SI on MRI) were detected in 94 patients. A final diagnosis of SpA was made in 103 patients (81 females, 22 males). Among SpA patients 24 had psoriasis, 3 inflammatory bowel disease, 3 uveitis, 5 were B27+, and they had mean BUSES of 4,1 and GEC of 1,2. The mean SIJs PDUS score was 1,3 in SpA and 0,52 in not-SpA patients. The mean SIJs RI was 0,53 in SpA and 0,68 in not-SpA patients. A significant correlation was demonstrated between MRI and PDUS diagnosis of SI (r=0,6486, p<0,0001), between MRI diagnosis and PD grading (r=0,4937, p<0,0001). The split analysis of peculiar parameters of imaging between the two methods also showed significant correlation: periarticular vascularity showed correlation with post-contrast MRI evidence of posterior capsulitis and enthesitis (p=0,001), as SIJs BME correlated with intra-articular PD signals (p<0,001). RI from SWA analysis was inversely correlated with MRI diagnosis of active SI (p<0.0001). SIJs PD demonstrated a significant correlation with SIJs pain (p<0,001), but not with inflammatory reactants, GEC, peripheral synovitis, and a weak correlation with BUSES (p=0,038).Conclusion:SIJs PDUS/SWA may be an optional method for preliminary screening of active SI, as a feasible, cheap and an accurate diagnostic tool, compared with MRI as a gold standard for nr-Axial SpA. PD US in SI. Right SI joint with a PD signal within inter-osseous ligament (curved arrow), where spectral PD analysis shows a RI of 0,62. Normal vessels (with high RI, unshowed) can be observed into the first sacral foramen (arrowhead). The first sacral apophysis (arrow) protrudes from the sacrum profile.Disclosure of Interests:None declared.
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Tesema, Zeleke, Kefyalew Alemayehu, Tesfaye Getachew, et al. "Genetic analysis of efficiency-related traits in Boer x Central Highland goats." PLOS ONE 19, no. 7 (2024): e0305749. http://dx.doi.org/10.1371/journal.pone.0305749.
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This study aimed to identify important non-genetic factors and estimate genetic parameters for efficiency-related traits in Boer x Central Highland goats. The genetic parameters were estimated using the Average Information Restricted Maximum Likelihood algorithm using the WOMBAT program fitting animal model. The least-squares means for growth efficiency from birth to 3 months (GE1), 3–6 months (GE2), 6–12 months (GE3), relative growth rate from birth to 3 months (RGR1), 3–6 months (RGR2) and 6–12 month (RGR3) were 294.0 ± 5.06, 36.6 ± 1.20, 44.9 ± 1.81, 1.46 ± 0.01, 0.32 ± 0.01 and 0.19 ± 0.01, respectively. Birth type, blood level, sex of the kid, and year of kidding had a sizable effect on efficiency-related traits. About 18, 3.0, 23, 20, and 12% of the phenotypic variation in GE2, GE3, RGR1, RGR2, and RGR3 was explained by the direct additive genetic effect. Except for RGR3, all investigated traits were under the influence of maternal genetic effect, and maternal heritability ranged from 0.09 to 0.17. The total heritability estimate depicts that slow genetic progress would be expected from selection. Nevertheless, even with this level of heritability, selection for efficiency-related traits would improve the efficiency of chevon production as these traits are economically important traits. Nearly six-months of age was when farmers sold Boer crossbred goats. Therefore, improving the growth efficiency till the marketing age (GE2) in such a scenario could increase the production efficiency.
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Abdullayeva, A. Ə., İ. İ. İsayev та A. İ. Mustafayeva. "ВОЗРАСТНАЯ ЗАВИСИМОСТЬ ИЗМЕНЕНИЙ ПОЗДНИХ ЖЕЛУДОЧКОВЫХ ПОТЕНЦИАЛОВ ПРИ ИДИОПАТИЧЕСКОЙ БЛОКАДЕ ПРАВОЙ НОЖКИ ПУЧКА ГИСА У ДЕТЕЙ". Azerbaijan Medical Journal, № 2 (28 вересня 2024): 5–9. http://dx.doi.org/10.34921/amj.2024.94.42.001.
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Məqalədə Hiss dəstəsinin sağ ayaqcığının idiopatik blokadası (HDSAB) olan uşaqlarda mədəciklərin gec potensiallarının (MGP) parametrlərini öyrənmək məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Tədqiqata cəlb edilmiş 127 uşaq 3 yaş qrupuna bölünmüşdür. Hər bir qrupda HDSAB olan əsas yarımqrup uşaqlar müvafiq yaşlı praktik sağlam olan kontrol yarımqrup uşaqlarla müqayisə edilmiştir. Bunlardan HDSAB olan 3-6 yaşlı 14 uşaq (7 oğlan, 7 qız) 1-ci qrupun əsas yarımqrupuna, eyni yaşlı 11 praktik sağlam uşaq isə kontrol yarımqrupuna daxil edilmişdir. HDSAB olan 7-11 yaşlı 34 uşaq (19 oğlan, 15 qız) 2-ci qrupun əsas yarımqrupuna, 11 praktik sağlam uşaq isə kontrol yarımqrupuna daxil edilmişdir. HDSAB olan 12-17 yaşlı 43 uşaq (27 oğlan, 16 qız) 3-cü qrupun əsas yarımqrupuna, 14 praktik sağlam uşaq isə kontrol yarımqrupuna daxil edilmişdir. Bütün uşaqlarda MGP-nin aşağıdakı parametrləri öyrənilmişdir: TotORS (ms) — filtrasiyaya uğramış QRS kompleksinin davametmə müddəti, LAS40 (ms) — QRS kompleksinin sonunda 40 mkV-dən aşağı tezliklə filtrasiyaya uğramış elektrik dalğaların davametmə müddəti, RMS40 (mkV) — filtrasiyaya uğramış QRS kompleksinin axırıncı 40 ms-lik müddəində orta kvadratik amplitudunu xarakterizə edən indeks və TotQRS / RMS40 nisbəti. Hər 3 qrupda HDSAB olan uşaqlarda sağlam uşaqlarla müqayisədə mədəciklərin gec potensiallarının göstəricilərində müəyyən meyletmələr aşkarlanmışdır: HDSAB olan uşaqlarda miokardda elektrofizioloji olaraq qeyri-homogenlik səbəbindən MGP ocaqları aşkarlanır. Ventrikulyar depolyarizasiyanın qeyri-homogenliyinin müxtəlif yaş dövrlərində bu səpkidə nəzərə çarpması gələcəkdə hər hansı bir metabolik pozulmanın və patologiyanın qoşulması səbəbindən daha təhlükəli aritmiya riskinə meyl yaradır. В статье представлены сведения об исследованиях, проведенных по изучению параметров поздних желудочковых потенциалов у детей с идиопатической блокадой правой ножки пучка Гиса (БПНПГ). К исследованию привлечены 127 детей с учетом периодов детства и возрастных особенностей. Из них 14 детей (7 мальчиков, 7 девочек) в возрасте 3-6 лет с БПНПГ вошли в основную группу 1-й группы, а в контрольную группу вошли 11 практически здоровых детей в возрасте 3-6 лет. В основную группу 2-й группы вошли 34 ребенка в возрасте 7-11 лет с БПНПГ (19 мальчиков, 15 девочек), а в контрольную группу – 11 практически здоровых детей в возрасте 7-11 лет. В основную группу 3-й группы вошли 43 ребенка в возрасте 12-17 лет с БПНПГ (27 мальчиков, 16 девочек), а в контрольную группу – 14 практически здоровых детей в возрасте 12-17 лет. У всех детей исследовали следующие параметры поздних потенциалов желудочков: TotORS (мс) - длительность фильтрованного комплекса QRS, LAS40 (мс) - длительность фильтрованных электрических волн с частотой ниже 40 мВ в конце комплекса QRS, RMS40 (мВ) - среднеквадратическое значение в течение последние 40 мс индекса отфильтрованного комплекса QRS, характеризующего его амплитуду и соотношение TotQRS/RMS40. Во всех 3 группах детей с БПНПГ выявлены определенные отклонения в показателях поздних потенциалов желудочков: за счет электрофизиологической неоднородности в миокарде у детей с БПНПГ выявлены очаги ППЖ. Эти случаи предрасполагают к более опасному риску возникновения аритмии вследствие присоединения в будущем любых других метаболических нарушений и патологий. The article provides information on the research conducted to study the parameters of late ventricular potentials in children with idiopathic right bundle branch block (RBBB). 127 children were involved in the study, taking into account the periods of childhood and age characteristics. These children are divided into 3 groups, 3-6 years old, Of these, 14 children (7 boys, 7 girls) aged 3-6 with RBBB were included in the main group of the 1st group, and 11 practically healthy children aged 3-6 were included in the control group. 34 children aged 7-11 years with RBBB (19 boys, 15 girls) were included in the main group of the 2nd group, and 11 practically healthy children aged 7-11 years were included in the control group. 43 children aged 12-17 years with RBBB (27 boys, 16 girls) were included in the main group of the 3rd group, and 14 practically healthy children aged 12-17 years were included in the control group. The following parameters of ventricular late potentials were studied in all children: TotORS (ms) - the duration of the filtered QRS complex, LAS40 (ms) - the duration of the filtered electrical waves with a frequency lower than 40 mV at the end of the QRS complex, RMS40 (mV) - filtered QRS index characterizing the mean square amplitude of the complex in the last 40 ms and the TotQRS/RMS40 ratio. In all 3 groups of children with RBBB, certain deviations in indicators of ventricular late potentials were found: in children with RBBB, VLP foci are detected due to electrophysiological inhomogeneity in the myocardium. These cases predispose to a higher risk of dangerous arrhythmias due to the addition of other metabolic disorders and pathologies in the future.
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Chi, Alexander, Mingcheng Gao, Nam P. Nguyen, and Kevin Albuquerque. "Technical Aspects of the Integration of Three-Dimensional Treatment Planning Dose Parameters (GEC-ESTRO Working Group) into Pre-implant Planning for LDR Gynecological Interstitial Brachytherapy." Technology in Cancer Research & Treatment 8, no. 3 (2009): 181–86. http://dx.doi.org/10.1177/153303460900800302.
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Ortiz, Ruy, Manuel López, Rosa E. Pérez, Paola de la Paz Ramírez, and Gerardo Ordaz. "Effect of the Inclusion of Different Levels of Dietary Cactus (Opuntia ficus-indica) on Gilts’ Biochemical Parameters and Feed Intake during Lactation." Animals 10, no. 10 (2020): 1881. http://dx.doi.org/10.3390/ani10101881.
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The regulation of sows’ metabolic state during the gestation-lactation transition is a requirement for a higher feed intake in lactation, an important aspect in improving animal welfare in current swine production systems. The present study aimed to evaluate the effects of the inclusion of different cactus (Opuntia ficus-indica L.) levels in the diet of gilts during late gestation and lactation on their biochemical parameters and voluntary feed intake during lactation. From day 85 of gestation until weaning, 40 gilts were divided into four groups: GNC (group with no cactus) with a basal diet (BD) only, G1C; group with 1% inclusion of cactus plus BD, G2C; group with 1.5% inclusion of cactus plus BD, and G3C; group with 2% inclusion of cactus plus BD. The dietary cactus supplementation increased the gilts’ feed intake (by 1.04 kg/day on average) during lactation and reduced their weight loss (4.3%) at weaning. The glucose concentrations were higher (range 73.0–83.9 mg/dL) in the GNC. The GNC had the highest triglyceride and cholesterol concentrations at day 100 of gestation. G3C had the highest osteocalcin concentration at day 100 of gestation. The highest feed intake and lowest glucose concentration were achieved with a cactus consumption of 1.04% in lactating gilts.
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Dimopoulos, Johannes C. A., Peter Petrow, Kari Tanderup, et al. "Recommendations from Gynaecological (GYN) GEC-ESTRO Working Group (IV): Basic principles and parameters for MR imaging within the frame of image based adaptive cervix cancer brachytherapy." Radiotherapy and Oncology 103, no. 1 (2012): 113–22. http://dx.doi.org/10.1016/j.radonc.2011.12.024.
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Mahantshetty, U., J. Swamidas, N. Khanna, R. Engineer, N. H. Merchant, and S. Shrivastava. "Magnetic Resonance Image-based Dose Volume Parameters and Clinical Outcome with High Dose Rate Brachytherapy in Cervical Cancers — A Validation of GYN GEC-ESTRO Brachytherapy Recommendations." Clinical Oncology 23, no. 5 (2011): 376–77. http://dx.doi.org/10.1016/j.clon.2011.02.006.
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Jaiswal, Swapnil G., and Satyanarayan Naik. "Contribution of Agricultural Produce Spice Zingiber Officinale to a Sustainable Food System: Green Extraction and Stability Study of Antioxidant Compounds." Open Agriculture 3, no. 1 (2018): 326–38. http://dx.doi.org/10.1515/opag-2018-0036.
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Abstract The present study has focused on the extraction and utilization of antioxidant compounds from the agricultural produce Zingiber officinale for its sustainable use in terms of stabilizing food from oxidation. Two extraction methods, traditional soxhlet and green supercritical CO2 (SC-CO2), were used to compare yields of antioxidant (6-gingerol) rich extracts. For the SC-CO2 method, operating parameters including pressure (10000-20000 kPa), temperature (30- 40°C) and CO2 flow rate (5-20 g/min.) were optimized to get maximum recovery of [6]-gingerol rich extracts. The results of the extraction study revealed that ginger extract collected after soxhlet extraction (GE1) gives more yield (3.85%) than the extract (2.41%) collected after SC-CO2 extraction (GE2) at an optimum condition of 20000 kPa pressure, 40°C temperature and 20 g/min. flow rate. Contrarily, the yield of [6]-gingerol was found to be greater in GE2 (389 mg/g) than GE1. Total phenol (TPC) and flavonoid (TFC) content of GE1 and GE2 were measured against equivalent concentrations of gallic acid and quercetin. TPC and TFC of GE1 show slightly higher values (38.50 mg GAE/g, 5.62 mg QE/g) than GE2. At the concentration of 3000 μg/mL, DPPH percent inhibition activity of GE1 was again higher (up to 94%) than GE2 (up to 82%). Stability study result of both GE1 and GE2 revealed on the basis of antioxidant indices, showed desirable antioxidant index by stabilizing all three experimented oils and also found to be comparable with synthetic antioxidants (BHA, BHT). Therefore, it could be concluded that [6]-gingerol rich extracts from the SC-CO2 method have comparable phenol flavonoid, antioxidant and stability potential as those found in ginger extracts from the traditional soxhlet method.
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Schönicke, Tom, Raphael Koch, Isabel Vogt, Isabel Falke, Hans Theodor Eich, and Gabriele Reinartz. "Retrospective Evaluation of GEC-ESTRO Constraints for Definitive Radiochemotherapy with Brachytherapy and Correlation with Oncologic Outcome in Cervical Cancer: A Monocenter Study." Cancers 16, no. 20 (2024): 3495. http://dx.doi.org/10.3390/cancers16203495.
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Background: This study aims to evaluate patients with locally advanced cervical cancer who underwent definitive radiochemotherapy, including brachytherapy, at the University Hospital of Muenster (UKM), focusing on target volume coverage, oncologic outcome parameters, and organs at risk (OAR) toxicities. Results are compared with the Gyn GEC-ESTRO (GGE) recommendations. Methods: Of a cohort of 48 patients, treated between 2013 and 2023, the physical radiation treatment planning with application of CT and MRI and oncologic follow-up data was analyzed. Target volume structures, comprising the high-risk clinical target volume (HR-CTV), intermediate-risk clinical target volume (IR-CTV), Point A, and corresponding EQD2(α/β=10) doses were determined. Endpoints included local tumor control, overall survival (OS), recurrence-free survival (RFS), and progression-free survival (PFS). Total OAR (D2cc) EQD2(α/β=3) doses were correlated with adverse events defined by CTCAE v5.0 and LENT-SOMA criteria. Results: Median follow-up was 58.0 months (95% CI [27.6, 88.4]). FIGO stage I was present in 7 (15%) patients, II in 13 (27%), and III in 28 (58%) patients. A total of 38 (79%) patients showed a complete remission 3 months after treatment. The 5-year event-free rate was 67.4% (95% CI [49.3, 80.3]) for OS, 77.0% (95% CI [56.7, 88.6]) for RFS and 68.1% (95% CI [49.7, 80.9]) for PFS. Incomplete radiation treatment and advanced tumor stages led to worse outcomes. Meeting Point A GGE recommendations increased chances for complete remission and could decrease chances of an event occurring for OS, PFS, and RFS. Compliance with GGE recommendations lowered the chances of OAR toxicity occurring. Conclusions: MRI-based target volume definition for brachytherapy in cervical cancer may improve patients’ OS, PFS, and RFS. Time-to-event endpoints are consistent with comparable studies, and adherence to current ESGO/ESTRO/ESP guidelines is endorsed.
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Silva, Luana Nascimento da, Lucas Kennedy Silva Lima, Idália Souza dos Santos, Sidnara Ribeiro Sampaio, Mauricio Antônio Coelho Filho, and Onildo Nunes de Jesus. "Biometrics and physiological parameters of sour passion fruit seedlings produced on organic substrates." February 2023, no. 17(02):2023 (February 2, 2023): 118–29. http://dx.doi.org/10.21475/ajcs.23.17.02.p3549.
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The organic fruit market has expanded considerably in recent years, but for the establishment of more productive organic orchards, several aspects need to be studied, starting with obtaining good quality seedlings. In this work, different formulations of organic substrates were evaluated to select the one that provides greater vigor to Passiflora edulis Sims seedlings. The study was conducted under anti-aphid screen conditions in two regions of Bahia (Recôncavo da Bahia, Chapada Diamantina), using a completely randomized design. The substrates were prepared using different proportions of coconut fiber, vermiculite, bovine manure and bokashi. At 60 days after sowing, germination vigor, gas exchange and growth parameters were evaluated. The data were submitted to principal component analysis and the groups formed were represented by box plots and compared by the Tukey test. Three groups were formed from PCA for the seedlings produced in both regions and the joint analysis, considering the two environments. In Chapada Diamantina, the seedlings produced in group 1, corresponding to 40% of the substrates tested, stood out for their root characteristics. In Recôncavo da Bahia, the seedlings showed low variation between the treatments G1C and G2C (80% substrates), compared to the G3C seedlings. The best performance was observed in the seedlings produced in Chapada Diamantina, but the use of coconut fiber and soil (CfSB), vermiculite and soil (SVB), both with 5% bokashi, produced excellent seedlings in both regions, so it is recommended for the organic production of P. edulis
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MANOHAR, G. K., and A. P. KESARKAR. "Climatology of thunderstorm activity over the Indian region : A study of east -west contrast." MAUSAM 54, no. 4 (2022): 819–28. http://dx.doi.org/10.54302/mausam.v54i4.1581.
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Based on the latest data (I. M. D., 1999) of monthly number of station thunderstorm days (Thn) and mean maximum surface air temperatures (Tmax) of 276 Indian stations, an important and a long pending issue of east- west contrast in the frequencies of occurrence of thunderstorms over India is resolved in substantial details in this study. On the premise of nearly equal land areas, and density of the station network, and location of ITCZ; India is divided in two regions: Eastern Region (ER) and Western Region (WR) across the 79° E longitude line over India. Results pertaining to the contrasting features of Thn over ER and WR are presented. Our analysis showed that the annual total Thn over the ER are 4763, and over the WR are 3194 and the prominent difference in Thn is associated with monsoon season months over the ER and WR. The temperature sensitivity of occurrence of Thn showed that thunderstorms respond exponentially to modest increment in Tmax on the semi-annual and annual time-scales in both the regions but with clear contrast in their sensitivity over ER. This result is in good agreement with the results cited in many studies, where relationship between global tropical surface air temperatures and GEC parameters are investigated. Our analysis suggests that the hot and humid extensive land region of the ITCZ of the ER is more suitable and responsible for the development of thunderstorms. Further, results showing higher values of CAPE and moisture field over the ER are discussed to explain the E-W pronounced contrast in the thunderstorm activity. It is believed that the results presented in this study will be useful.
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Zhang, Hanyi, Shun Lu, Chang Sun, and Jin Yi Lang. "Analysis of local control rate and toxicity of radiotherapy dose of cervical cancer." Journal of Global Oncology 5, suppl (2019): 136. http://dx.doi.org/10.1200/jgo.2019.5.suppl.136.
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136 Background: The standard of care for treatment of advanced cervical cancer is the combination of external beam radiation therapy (EBRT) and intracavitary brachytherapy with cisplatin based concurrent chemotherapy. Radiotherapy plays a crucial role in treatment of cervical cancer. Recent GEC-ESTRO guidelines recommend that the dose to 90% (D90) of the high-risk clinical target volume (HRCTV) in cervical cancer be at least 85Gy with higher doses for poor response to radiotherapy. This study was aim to analyze our institution’s patients with locally advanced cervical cancer in regards to whether higher brachytherapy dose delivery lead to a better outcome, and to investigate the proper dose to balance the local control rate and toxicity. Methods: A total of 262 patients with local advanced cervical cancer treated at a single institution were retrospectively analyzed for the association between dosimetry and outcomes. Youden index was used to identify the optimal cut-off point of continuous tumor parameters and divide patients into subgroups. Significance of radiotherapy dose parameters on OS, PFS, LRFS and DMFS and toxicity was evaluated. Results: In the univariate analysis, for both HR-CTV and LR-CTV, the high dose group (EQD2 D90 >75Gy, LR-CTV>68Gy, respectively) have a better LRFS than low-dose groups (P<0.05). LR-CTV remains significance after adjusted for age and FIGO stage. Moreover, in the high-dose LR-CTV group, there is no association between dose of LR-CTV and LRFS was found, however, higher dose of HR-CTV significant associated with higher ratio of side effect was found. In addition, no association of dose of HR-CTV or LR-CTV and OS were found for all patients. Conclusions: Our results showed that dose of LR-CTV may be a useful prognostic factor of LRFS of patients with cervical cancer. Moreover, after D90 of LR-CTV reaches 68Gy, increasing dose did not show a better LRFS but lead to higher ratio of toxicity, supporting that LR-CTV at 68Gy might be a safety and efficacy dose of radiotherapy to the patients with cervical cancer. However, further improved in dose had no significant benefit on local control rate, and it might increase the risks of toxicity.
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Bách, Phạm Tiến, Võ Đại Nhật, Nguyễn Việt Kỳ, and Lê Quân. "Maxwell model geotextile encased stone column in soft soil improvement." Science & Technology Development Journal - Engineering and Technology 4, no. 1 (2021): first. http://dx.doi.org/10.32508/stdjet.v4i1.772.
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In the field of geotechnical – soft soil improvement, the mathematical model or mechanical model is one of the important input parameters for the design calculations or studies. The determination of the appropriateness of the models has a great influence on the accuracy results of design and calculation as well as the sustainable stability of soft ground after improvement. On the contrary, the selection of inadequate calculation models will lead to increased costs of soft soil improvement, possibly even leading to the destabilization of the work and causing immense loss of people and property. Recently, many projects major highway after construction design in use has not meet the requirements of the standard, leading to wasted money and time of individuals, organizations, and the state of post-treatment. Therefore, the research and application of using mathematical or mechanical models in accordance with the new soft soil improvement method will greatly help as well as add additional options for soft soil improvement in Vietnam. The soft soil deformation is not only related to load but also to load time. The change in stress and deformation of weak soil over time is called rheology, and in this study is the viscoelastic behavior. From the above reasons, we try to apply a generalized Maxwell model to explain the viscoelastic behavior of a soft soil. In particular, the time-dependent behavior of a viscoelastic soft soil was represented by using the Maxwell rheological model. The Matlab programming code helps to solve numerically all the equation of the mathematical exhibition of the generalized Maxwell model results. We acknowledge that the generalized Maxwell model is superior in demonstrating the time-dependent behavior of soft soil. The results probably show that this is one of the effective models to predict the behavior of soft soils in ground improvement with GEC.
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Landjev, Ivan, Emiliyan Rogachev, and Assia Rousseva. "Characterization of some minihypers in PG(4,3)." Annual of Sofia University St. Kliment Ohridski. Faculty of Mathematics and Informatics 109 (December 12, 2022): 91–98. http://dx.doi.org/10.60063/gsu.fmi.109.91-98.
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In this paper we characterize the minihypers with parameters $(66,21)$ in the geometry PG(4,3). These parameters are important because they are instrumental in solving the problem of the existence of several hypothetical ternary Griesmer codes of dimension $6$. This classification gives also insight into the classification problem for $(v_r+2v_{r-1},v_{r-1}+2v_{r-2})$-mimihypers in PG$(r,q)$ for any $r\ge3$ and any prime power $q\ge4$.
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Pötter, Richard, Christine Haie-Meder, Erik Van Limbergen, et al. "Recommendations from gynaecological (GYN) GEC ESTRO working group (II): Concepts and terms in 3D image-based treatment planning in cervix cancer brachytherapy—3D dose volume parameters and aspects of 3D image-based anatomy, radiation physics, radiobiology." Radiotherapy and Oncology 78, no. 1 (2006): 67–77. http://dx.doi.org/10.1016/j.radonc.2005.11.014.
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Filep, M. J., A. I. Pogodin, T. O. Malakhovska, and O. P. Kokhan. "SINGLE CRYSTALS GROWTH IN THE HOMOGENEITY REGION OF LOW-TEMPERATURE MODIFICATION OF Ag8GeS6." Scientific Bulletin of the Uzhhorod University. Series «Chemistry» 48, no. 2 (2023): 38–42. http://dx.doi.org/10.24144/2414-0260.2022.2.38-42.
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Cationic ion-conductors have found wide practical application as electric batteries. Among them the lithium-ion batteries are the most common commercially used. However, research is being actively carried out to improve the safety of these batteries. Among the possible compounds, silver-containing phases are attractive, since silver-ions, along with high values of ionic conductivity in solid-state, haven’t high chemical activity like the same alkali metal-ions. Realization of the crystal structure necessary for effective ion transport is observed in compounds of the argyrodite structure - a group of ternary chalcogenides and quaternary chalcohalogenides of multi-charged cations (Ge4+, Si4+, P5+). In this work, a study of heterovalent cationic P5+→Ge4+ substitution in the Ag8GeS6 enriched region was carried out. Single crystals of Ag8-x(Ge1-xPx)S6 (x = 0.25; 0.5) solid solutions were grown by the method of directional crystallization using a solution-melt technique. The grown single crystals are characterized by the absence of macrodefects, a dark gray color with a metallic luster, and dimensions of l = ~3 cm and d = 1.2 cm. Using the Rietveld refinement method, the crystal structure was established and the lattice parameters of Ag8-x(Ge1-xPx)S6 (x = 0.25; 0.5) solid solutions were determined. Established, that single crystals of Ag8-x(Ge1-xPx)S6 (x = 0.25; 0.5) solid solutions crystallize in the orthorhombic crystal system in a primitive cell with space group Pna21.
 Keywords: argyrodites; single crystals; directional crystallization; phase analysis.
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Suriyajunhom, Pornthip, and Maradee Phongpipatpong. "Optimization of drum drying parameters for gac powder." MATEC Web of Conferences 192 (2018): 03046. http://dx.doi.org/10.1051/matecconf/201819203046.
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Gac (Momordica cochinchinensis Spreng.) is a tropical fruit which contains a rich nutrient source, especially lycopene. However, fresh gac fruit can spoil rapidly due to its high moisture content. Drum drying is a process to remove moisture from food in order to preserve nutrients and extend shelf life. In this study, gac fruit powder was produced by using drum drying technique. The present research was aimed to determine the optimum drum drying condition for gac powder. Response Surface Methodology was employed with three processing variables, including drum surface drying temperature (115, 125, 135˚C) maltodextrin content (100, 150, 200%) and gum arabic content (10, 20, 30%). The response variables were moisture content, solubility, hygroscopicity, total phenolic content and lycopene content of gac fruit powder. Regression analysis was then performed to obtain the mathematical relation between the processing variables and the responses in the form of second-order polynomial equations.. The results showed that optimum conditions for drum drying of gac fruit was at 135˚C of drum surface drying temperature, 138% of added maltodextrin and 10% of added gum arabic, which provided the highest amount of total phenolic and lycopene content.
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Ahuja, Sana, Adil Aziz Khan, Pooja Verma, and Sufian Zaheer. "Association of tumor budding and tumor infiltrating lymphocytes with clinicopathological parameters in gallbladder carcinoma." Korean Journal of Clinical Oncology 20, no. 1 (2024): 1–5. http://dx.doi.org/10.14216/kjco.24001.
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Purpose: Gallbladder carcinoma (GBC) poses significant challenges in oncology due to its aggressive nature and limited treatment options. The lack of effective biomarkers for early detection and prognosis exacerbates the prognosis for GBC patients. Tumor budding (TB) and tumor infiltrating lymphocytes (TILs) have emerged as potential prognostic indicators in various cancers, reflecting tumor-host immune interactions and tumor aggressiveness. The study of TB and TILs in GBC is particularly important due to the limited literature available.Methods: This retrospective observational study aimed to evaluate the association of TB and TILs with clinicopathological parameters in GBC patients. Clinicopathological data were collected from patients with histologically confirmed GBC who underwent surgical resection. The sections were evaluated for TB and TILs using standardized methods. Statistical analysis was performed to assess associations between these parameters and clinicopathological variables.Results: Tumor stage and grade showed significant associations with TB and TILs, indicating their potential as prognostic markers. High TB correlated with advanced tumor stage and higher grade, while high TIL infiltration was associated with early tumor stage and lower grade. Additionally, TILs exhibited a significant association with lymphovascular invasion. Interestingly, an inverse association was observed between TB and TILs, highlighting the dynamic interplay between tumor aggressiveness and host immune response.Conclusion: TB and TILs hold prognostic significance in GBC, offering insights into its pathogenesis and potential therapeutic targets. Future research exploring the mechanistic underpinnings of tumor-host immune interactions in GBC is crucial for translating these findings into clinical applications and improving outcomes for patients.
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Ameer, Moavia, Muhammad Abbas, Thabet Abdeljawad, and Tahir Nazir. "A Novel Generalization of Bézier-like Curves and Surfaces with Shape Parameters." Mathematics 10, no. 3 (2022): 376. http://dx.doi.org/10.3390/math10030376.
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Bézier curves and surfaces with shape parameters have received more attention in the field of engineering and technology in recent years because of their useful geometric properties as compared to classical Bézier curves, as well as traditional Bernstein basis functions. In this study, the generalized Bézier-like curves (gBC) are constructed based on new generalized Bernstein-like basis functions (gBBF) with two shape parameters. The geometric properties of both gBBF and gBC are studied, and it is found that they are similar to the classical Bernstein basis and Bézier curve, respectively. Some free form curves can be modeled using the proposed gBC and surfaces as the applications.
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Yang, Huawei, Tongyang Shi, and J. S. Bolton. "Granular activated carbon sound absorption predictions made using measured material parameters." Journal of the Acoustical Society of America 155, no. 3_Supplement (2024): A26. http://dx.doi.org/10.1121/10.0026665.
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Granular activated carbon (GAC) is hierarchical porosity material that yields better in low frequency sound absorption performance compared with many traditional porous materials due to the sorption effect created by nanometer-scale pores within the particles. In 2017, a triple porosity model accounting for the sorption effect in the micropores was proposed by Venegas et al. In the proposed model, some of input parameters (i.e., mesopore size and micropore effective diffusion coefficient) were fitted by matching the model to measured the surface impedance of a GAC stack; however, some fitted values are questionable from an inorganic material perspective. In the present work, the GAC material parameters, such as micro- and meso-pore sizes, were estimated from a standard isotherm measurement. The measurement results showed a standard Langmuir type isotherm behavior at different temperatures: i.e., 273.15 and 293.15 K. Thus, if the isotherms can be described with the Langmuir model, then the Langmuir constant and heat of adsorption can be estimated based on the isotherms. Finally, these parameters were used as the input to the GAC model and the absorption coefficient was calculated. The calculated result was also compared with the absorption coefficient measured following the E1050 standard.
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Abdullaiev, R. Ya, V. A. Kapustnik, V. D. Markovsky, F. I. Kulikova, A. G. Kyrychenko, and N. V. Tomakh. "GECİKMİŞ POSTİNFARKT DÖVRDƏ ÜRƏYİN REMODELLƏŞMƏSİNİN XÜSUSİYYƏTLƏRİ." Azerbaijan Medical Journal, no. 3 (September 30, 2023): 9–14. http://dx.doi.org/10.34921/amj.2023.3.002.
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The article presents the results of echocardiography in assessing cardiac remodeling in 79 patients 12 months after acute myocardial infarction (MI). 42 (53.2%) patients had Q-positive (Q+), 37 (46.8%) Q-negative (Q-) myocardial infarction. After 12 months, chronic heart failure (ChHF) was detected in 32 patients, of which 23 (54.8%) as a result of Q(+), and 9 (24.3%) Q(-) infarction. In patients who underwent Q (+) MI with ChHF in the late post-infarction period, the values of left ventricular end-diastolic dimension (EDD), end-sistolic dimension (ESD), left atrial dimension (LAD), local contractility index (LCI), sphericity index (SI), left ventricular myocardial mass index (LV MMI, g/m2) were significantly (P<0.05, P<0.01) higher than in patients with Q ( -) MI and without ChHF. The average value of such EchoCG parameters as ejection fraction (EF, %), degree of shortening of the anteroposterior dimension of the left ventricle (ΔS, %) and the ratio of the total wall thickness and LV EDD (2H/D index) in patients with Q (-) MI was higher than in the group of patients with Q (+) and without ChHF. Məqalədə 79 xəstədə kəskin miokard infarktından (MI) sonrakı 12-ci aya qədər ürəkdə baş verən remodelləşmə proseslərinin qiymətləndirilməsi məqsədilə aparılan exokardioqrafiya müayinəsinin nəticələri haqqında məlumatlar təqdim edilir. Xəstələrdən 42 (53,2%) nəfər Q pozitiv (Q+), 37 nəfər (46,8%) Q neqativ (Q-) infarkt keçirmişdir. 12 ay sonra 32 xəstədə xronik ürək çatışmazliği (XÜÇ) aşkar edilmişdir, onlardan 23 (54,8%) nəfər Q (+), 9 (24,3%) nəfərdə isə Q (-) infarkt keçirən xəstə qruplarına aid idi. Q (+) MI keçirən və infarktdan sonrakı gec dövrdə XÜÇ olan xəstələrdə sol mədəciyin EDR (mm), ESR (mm), LA (mm), ILS, IS, LVMI (mm. Hg) dəyərləri XÜÇ olmayan və Q (-) MI keçirmiş xəstələrə nisbətən əhəmiyyətli dərəcədə yüksək olmuşdur (p<0,05, p<0,01). Q (-) MI keçirmiş və XÜÇ olmayan xəstələrdə isə EF, ΔS və 2H/D kimi EchoCG parametrlərinin orta dəyəri Q (+) və XÜÇ olan xəstələr qrupuna nisbətən daha yüksək olmuşdur. В статье представлены результаты эхокардиографии, проведенного с целью оценить ремоделирования сердца у 79 больных через 12 мес. после острого инфаркта миокарда (ИМ). 42 (53,2%) больных перенес Q-положительный (Q+), 37 (46,8%) Q-отрицательный (Q-) инфаркт миокарда. Через 12 мес. хроническая сердечная недостаточность (ХСН) выявлена у 32 больных, из них у 23 (54,8%) в результате Q (+), а у 9 (24,3%) Q (-) инфаркта миокарда. У пациентов перенесших Q (+) ИМ с наличием ХСН в позднем постинфарктном периоде величина КДР, КСР, ЛП, ИЛС, ИС, ИММлж была достоверно (p<0,05, p<0,01) выше, чем у пациентов с Q (-) ИМ и без ХСН. редняя величина таких ЭхоКГ параметров, как ФВ, ΔS и 2H/D у пациентов с Q (-) ИМ были выше, чем в группе пациентов с Q (+) и без ХСН.
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Childress, Ann, Andrew Cutler, Len Adler, et al. "Qelbree (viloxazine extended-release capsules): Final Results of the Long-Term, Phase 3, Open-Label Extension Trial in Adults with ADHD." CNS Spectrums 29, no. 5 (2024): 479–80. https://doi.org/10.1017/s1092852924001263.
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IntroductionViloxazine extended-release (ER) is an FDA-approved nonstimulant medication for ADHD in children (≥6 years) and adults. Approval in adults was based on a double-blind (DB) pivotal trial [NCT04016779] showing statistically significant efficacy on the Adult ADHD Investigator Symptom Rating Scale (AISRS; primary outcome). Here we report final results from the long-term, open-label extension (OLE) safety trial [NCT04143217] conducted as a following to the DB trial.MethodsUpon completing DB treatment, consenting subjects who enrolled in the OLE received viloxazine ER 200 mg/day, with flexible titration to an optimal maintenance dose (200-600 mg/day). Addition of a stimulant was permitted, at investigator’s discretion, following Week 12. OLE trial enrollment was temporarily closed at the outset of the COVID pandemic. Subjects completing the DB during this time were allowed delayed entry into the OLE upon requalification. Safety and efficacy measures were assessed relative to DB (or OLE re-entry) Baseline) at OLE Weeks 2, 4, and ~ every 8 weeks thereafter. The trial was planned for 3 years or until commercial availability of viloxazine ER.ResultsSubjects (N= 159; including 133 immediate- and 26 delayed-rollover) received viloxazine ER for 265 ± 254.9 days (mean ± SD). Nine subjects used adjunctive stimulant medication at some point after Week 12. Primary reasons for discontinuation included withdrawal of consent (25.6%), loss to follow up (17.7%), and adverse events (17.6%). Adverse events (experienced by 72.3%) were largely mild (26.4%) or moderate (40.3%) in severity and included (≥10%) insomnia (13.8%), nausea (13.8%), headache (10.7%), and fatigue (10.1%). Changes in clinical laboratory measures, vital signs, and ECG parameters were consistent with those observed in DB and product labeling. Suicidal ideation (wish to be dead) was reported by 3 subjects at a single visit each; no subject reported suicidal behavior. ADHD symptom (AISRS), executive function (BRIEF-A), global function (CGI), and quality of life (AAQOL) measures showed continued improvement in the OLE relative to that seen in DB. Baseline [mean ± SD)] AISRS Total, CGI-S, BRIEF-A GEC T-score and AAQOL ratings, respectively, were 37.9 ± 6.34), 4.6 ± 0.60, 70.4 ± 10.94 and 54.9 ± 14.96. All showed significant improvement (P<.0001 relative to Baseline) by the first OLE follow-up assessment (Week 2 for AISRS and CGI-S, Week 4 for BRIEF-A and AAQOL). Improvement continued with long-term use. Subjects maintained on viloxazine ER for at least 3 months (≥ Week 12) showed changes at Last OLE Visit of -20.0 ± 11.63 (n=106), -1.8 ± 1.34, -13.6 ± 13.64 (n=104), and 12.7 ± 17.90 (n=87) respectively.ConclusionsSubjects maintained on viloxazine ER showed continued improvement in ADHD symptoms, global and executive function, and quality of life measures during long-term treatment.FundingSupernus Pharmaceuticals, Inc.