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Rozprawy doktorskie na temat „Genetic code”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Nicholls, Felicity K. M. "Genetic analysis of the gene Additional sex combs and interacting loci." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29644.

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In order to recover new mutant alleles of the Polycomb group gene Additional sex combs (Asx), mutagenized chromosomes were screened over the putative Asx allele XT129. Thirteen new mutant strains that fail to complement XT129 were recovered. Unexpectedly, the thirteen strains sorted into four complementation groups. Recombination mapping suggests that each complementation group represents a separate locus. The largest group fails to complement a deletion of Asx and maps in the vicinity of 2-72, the published location of Asx. All new mutant strains enhance the phenotype of Polycomb mutant flies

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Mat, Wai Kin. "Genetic code mutants of bacillus subtilis /." View abstract or full-text, 2007. http://library.ust.hk/cgi/db/thesis.pl?BICH%202007%20MAT.

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Freeland, Stephen J. "Natural selection and the genetic code." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313922.

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Gutfraind, Alexander. "Error-Tolerant Coding and the Genetic Code." Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2913.

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The following thesis is a project in mathematical biology building upon the so-called "error minimization hypothesis" of the genetic code. After introducing the biological context of this hypothesis, I proceed to develop some relevant information-theoretic ideas, with the overall goal of studying the structure of the genetic code. I then apply the newfound understanding to an important question in the debate about the origin of life, namely, the question of the temperatures in which the genetic code, and life in general, underwent their early evolution. <br /><br /> The main advance

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Mateus, Denisa Daud. "Molecular reconstruction of a genetic code alteration." Doctoral thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7501.

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Doutoramento em Bioquímica<br>The genetic code establishes the rules that govern gene translation into proteins. It was established more than 3.5 billion years ago and it is one of the most conserved features of life. Despite this, several alterations to the standard genetic code have been discovered in both prokaryotes and eukaryotes, namely in the fungal CTG clade where a unique seryl transfer RNA (tRNACAG Ser) decodes leucine CUG codons as serine. This tRNACAG Ser appeared 272±25 million years ago through insertion of an adenosine in the middle position of the anticodon of a tRNACG

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Gomes, Ana Catarina Batista. "Molecular evolution of a genetic code alteration." Doctoral thesis, Universidade de Aveiro, 2008. http://hdl.handle.net/10773/939.

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Doutoramento em Biologia<br>Durante os últimos anos, foram descritas alterações ao código genético, quer em procariotas, quer em eucariotas, quebrando o dogma de que o código genético é universal e imutável. Estudos recentes sugerem que a evolução de tais alterações requerem modificações ao nível da estrutura da maquinaria da tradução e são promovidas por mecanismos de descodificação ambígua. Em C. albicans, um organismo que é patogénico para o Homem, a alteração ao código genético é mediada por uma alteração na estrutura de um novo tRNACAG de serina que descodifica o codão CUG de leuci

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Silva, Raquel Monteiro Marques da. "Molecular reconstruction of a genetic code alteration." Doctoral thesis, Universidade de Aveiro, 2005. http://hdl.handle.net/10773/948.

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Doutoramento em Biologia<br>Várias espécies de Candida traduzem o codão CUG de leucina como serina. Esta alteração ao código genético é mediada por um novo tRNA (sertRNACAG), que pode ser carregado com serina (97 %) e leucina (3 %) in vivo. Por esta razão o codão CUG é ambíguo, pois pode ser descodificado como serina ou leucina. Para elucidar o impacto da ambiguidade do código genético na expressão génica e na fisiologia da célula, o ser-tRNACAG de C. albicans foi expresso em Saccharomyces cerevisiae. Isto induz a descodificação ambígua do codão CUG, devido à competição entre o tRNA end

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Bezerra, Ana Rita Macedo. "Molecular genomics of a genetic code alteration." Doctoral thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/12499.

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Doutoramento em Biologia<br>The genetic code is not universal. Alterations to its standard form have been discovered in both prokaryotes and eukaryotes and demolished the dogma of an immutable code. For instance, several Candida species translate the standard leucine CUG codon as serine. In the case of the human pathogen Candida albicans, a serine tRNA (tRNACAGSer) incorporates in vivo 97% of serine and 3% of leucine in proteins at CUG sites. Such ambiguity is flexible and the level of leucine incorporation increases significantly in response to environmental stress. To elucidate the function

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Lajoie, Marc Joseph. "Genome Engineering Technologies to Change the Genetic Code." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11265.

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New technologies are making it possible to engineer organisms with fundamentally new and useful properties. In vivo genome engineering technologies capable of manipulating genomes from the nucleotide to the megabase scale were developed and applied to reassign the genetic code of Escherichia coli. Such genomically recoded organisms show promise for thwarting horizontal gene transfer with natural organisms, resisting viral infection, and expanding the chemical properties of proteins.

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Jääskelä, E. (Esa). "Genetic algorithm in code coverage guided fuzz testing." Master's thesis, University of Oulu, 2016. http://urn.fi/URN:NBN:fi:oulu-201601151058.

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The security of computers is a growing concern when the amount of devices increases. New and more comprehensive testing methods need to be done to avoid damages to the users and their computers. Fuzzing is a testing method that inserts semi-valid input to the tested system and has before been considered as a good method for the security testing. However, it usually either does not get high code coverage or it requires a long set-up process or a source code analysis to achieve better code coverage. This work presents a genetic algorithm that automatically balances the probabilities of multiple

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Grasso, Katherine Taylor. "Resolving the Limitations of Genetic Code Expansion Platforms:." Thesis, Boston College, 2021. http://hdl.handle.net/2345/bc-ir:109076.

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Thesis advisor: Abhishek Chatterjee<br>Thesis advisor: Eranthie Weerapana<br>Over the past twenty years, the site-specific incorporation of unnatural amino acids (UAAs) into a target protein through genetic code expansion (GCE) has emerged as one of the foremost technologies to selectively modify proteins in their native cellular context. This technology relies on engineered aminoacyl-tRNA synthetase (aaRS)/tRNA pairs that are orthogonal to the host cells’ endogenous aaRS/tRNA pairs. Traditionally, scientists look towards evolutionarily distant domains of life to identify orthogonal aaRS/tRNA

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Iqbal, Emil S. "In vitro genetic code expansion and selected applications." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5580.

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The ability of incorporation non-canonical amino acids (ncAAs) using translation offers researchers the ability of extend the functionality of proteins and peptides for many applications including synthetic biology, biophysical and structural studies, and discovery of novel ligands. Here we describe the three projects where the addition of ncAAs to in vitro translation systems creates useful chemical biology techniques. In the first, a fluorinated histidine derivative is used to create a novel affinity tag that allows for the selective purification of peptides from a complex mixture of protein

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Ma, Natalie Jing. "Altering the Genetic Code to Probe and Control the Flow of Genetic Information." Thesis, Yale University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10584955.

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<p> The genetic code is highly conserved across all domains of life, enabling horizontal gene transfer (HGT) between organisms and across ecosystems via horizontally-transferred genetic elements such as viruses and plasmids. While HGT increases genetic diversity, it poses a risk to engineered biological systems by introducing new genes that destabilize engineered functions or allowing the expression of engineered genes in wild organisms with unknown effects. A model organism engineered with an alternative genetic code may provide new insight into the origins of the genetic code while also prov

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14

Ording, Marcus. "Context-Sensitive Code Completion : Improving Predictions with Genetic Algorithms." Thesis, KTH, Skolan för informations- och kommunikationsteknik (ICT), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-205334.

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Within the area of context-sensitive code completion there is a need for accurate predictive models in order to provide useful code completion predictions. The traditional method for optimizing the performance of code completion systems is to empirically evaluate the effect of each system parameter individually and fine-tune the parameters. This thesis presents a genetic algorithm that can optimize the system parameters with a degree-of-freedom equal to the number of parameters to optimize. The study evaluates the effect of the optimized parameters on the prediction quality of the studied code

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Massey, Steven Edward. "Codon reassignment and the evolution of the genetic code." Thesis, University of Kent, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399606.

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Italia, James Sebastian. "Development and Applications of Universal Genetic Code Expansion Platforms:." Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108354.

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Thesis advisor: Abhishek Chatterjee<br>The emergence of genetic code expansion (GCE) technology, which enables sitespecific incorporation of unnatural amino acids (UAAs) into proteins, has facilitated powerful new ways to probe and engineer protein structure and function. Using engineered orthogonal tRNA/aminoacyl-tRNA synthetase (aaRS) pairs that suppress repurposed nonsense codons, a variety of structurally diverse UAAs have been incorporated into proteins in living cells. This technology offers tremendous potential for deciphering the complex biology of eukaryotes, but its scope in eukaryot

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Mukre, Prakash. "Hardware accelerator for DNA code word searching." Diss., Online access via UMI:, 2008.

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Thesis (M.S.)--State University of New York at Binghamton, Thomas J. Watson School of Engineering and Applied Science, Department of Electrical and Computer Engineering, 2008.<br>Includes bibliographical references.

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Abedi, Saied. "Genetic multi-user detection for code division multiple access systems." Thesis, University of Surrey, 2000. http://epubs.surrey.ac.uk/843016/.

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The origins of spread spectrum are in navigation and military systems. Techniques originally developed to reduce the effects of the intentional jamming also proved suitable for communications through dispersive channels in cellular applications. In 1949 the first time hoping spread spectrum multiple access system has been introduced by John Pierce. A direct-sequence spread spectrum system has been proposed by De Rosa-Rogoff later in 1950. He has also introduced the concept of processing gain. However the commercialisation of cellular direct-sequence code division multiple access (DS-CDMA) syst

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Grewal, Gary William. "Enhanced genetic algorithms and their application in retargetable code generation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0008/NQ33302.pdf.

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Miranda, Isabel Alexandra Marcos. "Molecular study of a genetic code alteration in C. albicans." Doctoral thesis, Universidade de Aveiro, 2006. http://hdl.handle.net/10773/8980.

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Doutoramento em Biologia<br>A maioria dos organismos utiliza o mesmo código genético, no entanto alterações a este código padrão foram descobertas em procariotas e eucariotas. A maior parte das alterações ao código genético ocorre em mitocôndrias. No citoplasma eucariótico, o único exemplo conhecido de alteração ao código genético envolvendo a substituição de um aminoácido por outro aminoácido, ocorre em várias espécies do género Candida. Em Candida albicans o codão CUG é ambíguo, ou seja, pode ser traduzido como serina ou leucina, com predominância para o primeiro aminoácido. Na origem

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21

Madrzak, Julia. "Site-specific ubiquitination of recombinant proteins via genetic code expansion." Thesis, University of Cambridge, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708739.

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Shi, Aishan. "Decoding the Genetic Code: Unraveling the Language of Scientific Paradigms." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297762.

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Scientific revolutions have not only significantly broadened our knowledge underlying physical laws and natural patterns, but also shifted the cultural paradigm through which science is understood and practiced. These paradigm shifts, as Thomas Kuhn denoted them, are facilitated through changes in language, because language is the only method of articulating - and thereby establishing - truth, according to Friedrich Nietzsche and Michel Foucalt. Steven Shapin analyzed the progression of these linguistic changes in global scientific revolutions and Bruno Latour categorized them in the local lab

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Willis, Julian C. W. "Developing new orthogonal tRNA/synthetase pairs for genetic code expansion." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/274057.

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Pinto, Desterro Maria Joana. "Role of SUMO-1 modification in transcriptional activation." Thesis, University of St Andrews, 1999. http://hdl.handle.net/10023/2724.

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In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway. Targeting the proteins for ubiquitin-mediated proteolysis is an irrevocable decision, and as such, the process needs to be highly specific and tightly regulated. This task is achieved by conjugation and deconjugation enzymes that act in a dynamic and coordinated mechanism. In a yeast two hybrid screen designed to identify proteins involved in IκBα sign

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Tsai, Ya-Lin. "Development of parallel processing algorithms to provide automatic image analysis for medical application." Thesis, University of Sunderland, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336914.

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This thesis describes the development of: (i) an automatic chromosome analysis system capable of producing to a high degree of accuracy and consistency a correct classification for damaged chromosomes at a low cost and (ii) a parallel computer system to enable more rapid chromosome analysis. Chromosomes can be examined in a cytogenetics laboratory for a variety of purposes including an assessment of the affects of ionisation exposure on the genetic code of the cell. Scoring of chromosome aberrations caused by ionisation of radiation exposure, is possible by detecting dicentric chromosomes. In

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Han, Tony. "SWASAD Smith & Waterman-algorithm-specific ASIC design /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16391.pdf.

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Henderson, Daryl Stewart. "A genetic analysis of mutagen-sensitive mutations on the second chromosome of Drosophila melanogaster." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26418.

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Mutagen-sensitive (mus) mutations in Drosophila melanogaster render developing flies hypersensitive to the lethal effects of DNA-damaging agents. In general, mus mutations identify DNA repair-related genes. In this study, 5 new second chromosome mus mutations (mus205B¹, mus208B¹, mus209B¹, mus210B¹ and mus211B¹), selected on the basis of sensitivity to methyl methanesulfonate (MMS), were characterized using a variety of genetic tests. One test measured the MMS-sensitivity of double mutant mus strains compared to their component single mutants. Mutant interactions were examined in 8 double mus

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Cai, Zesi. "Genetic Algorithm for Integrated SoftwarePipelining." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76088.

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The purpose of the thesis was to study the feasibility of using geneticalgorithm (GA) to do the integrated software pipelining (ISP). Different from phasedcode generation, ISP is a technique which integrates instruction selection, instructionscheduling, and register allocation together when doing code generation. ISP is able toprovide a lager solution space than phased way does, which means that ISP haspotential to generate more optimized code than phased code generation. However,integrated compiling costs more than phased compiling. GA is stochastic beam searchalgorithm which can accelerate t

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Brodyk, Andr?? Art College of Fine Arts UNSW. "Genetic art and recombinants: introns non-code and the proto-animate condition." Awarded By:University of New South Wales. Art, 2009. http://handle.unsw.edu.au/1959.4/44087.

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This thesis examines how a contemporary biological model namely genetic recombinant DNA and technologies can be interpreted to develop new creative art-based recombinant processes and media. This question is investigated through a focus on practice-led research, on materiality and novel methodologies. The materiality centers on the development of new biologically based Genetic art media. These new methodologies entail practice-based interpretations and experimentation of literal and invented molecular recombinant DNA processes. These procedures necessitated working inside molecular biology la

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Moghal, Adil Baig. "Context-dependent threats to the fidelity of translation of the genetic code." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1465925323.

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Cardno, Tony Stuart, and n/a. "Development of a high throughput fluorescent screening assay for genetic recoding." University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20071218.145806.

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The development of new drug therapies traditionally requires mass screening of thousands if not millions of substances to identify lead compounds. They are then further optimised to increase potency. The screening of the large pharmaceutical compound libraries can be incredibly expensive, with the industry responding by miniaturising the assays to smaller formats, enabling the compound screening to be automated and, importantly, eliminating assay reagents that are a major contributing cost for running large screens. A potential target for such an approach is the genetic recoding site of viru

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Butarbutar, Nunut. "Analysis of yeast codon usage patterns using the movable ORF collection /." Online version of thesis, 2007. http://hdl.handle.net/1850/5700.

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Forrest, Megan E. "Regulation of Mammalian Messenger RNA Stability via the Open Reading Frame." Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1579862741902687.

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Wang, Shu-Zhen. "Isolation and characterization of the messenger RNA and the gene coding for a proline-rich zein from corn endosperm." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/49959.

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Gamma-zein, a proline-rich protein from corn endosperm, was investigated at the molecular level. Immunological and electrophoretic data indicated that gamma-zein was deposited into protein bodies in corn endosperm. Both isolated polysomes and poly(A)⁺ mRNA were found to direct in vitro synthesis of gamma-zein in a wheat germ system. In vitro synthesized gamma-zein was immunoprecipitated from the total in vitro translation products. A cDNA expression library was constructed by reverse transcription of total poly(A)⁺ mRNA using pUC8 plasmid as vector and <i>E. coli</i> strain DH1 as host. The li

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Johansen-Leete, Jason Paul. "Discovery of Bioactive macrocyclic peptides using mRNA display with genetic reprogramming." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/29467.

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Macrocyclic peptides are attractive for their favourable drug-like properties, bridging the gap between small molecules and biologics. Whilst nature is a rich source of bioactive macrocyclic peptides, their de novo discovery would access the full potential of this chemotype for therapeutic use. Using its ultra-large libraries of >1012 unique peptides, mRNA display is a powerful method of de novo ligand discovery against protein target. Genetic reprogramming can be exploited to display peptides with modified structures to improve their drug-like properties, such as affinity and cell-permeabili

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Silva, Ana Rita Guimarães Rodrigues da. "Codon ambiguities as a mechanism to alter the genetic code in Saccharomyces cerevisiae." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/15394.

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Mestrado em Biologia Molecular e Celular<br>Although the genetic code is generally viewed as immutable, alterations to its standard form occur in the three domains of life. A remarkable alteration to the standard genetic code occurs in many fungi of the Saccharomycotina CTG clade where the Leucine CUG codon has been reassigned to Serine by a novel transfer RNA (Ser-tRNACAG). The host laboratory made a major breakthrough by reversing this atypical genetic code alteration in the human pathogen Candida albicans using a combination of tRNA engineering, gene recombination and forced evolution. Thes

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Qi, Xin Dervan Peter B. "Unnatural amino acid incorporation to rewrite the genetic code and RNA-peptide interactions /." Diss., Pasadena, Calif. : California Institute of Technology, 2005. http://resolver.caltech.edu/CaltechETD:etd-05272005-133323.

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Kinney, William D. "Expansion of the Genetic Code to Include Acylated Lysine Derivatives and Photocaged Histidine." VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5903.

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The genetic code of all known organisms is comprised of the 20 proteinogenic amino acids that serve as building blocks on a peptide chain to form a vast array of proteins. Proteins are responsible for virtually every biological process in all organisms; however, the 20 amino acids contain a limited number of functional groups that often leaves much to be desired. The lack of diversity addresses the need to increase the genetic repertoire of living cells to include a variety of amino acids with novel structural, chemical, and physical properties not found in the common 20 amino acids. In order

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Mathew, Suneeth Fiona, and n/a. "Understanding genetic recoding in HIV-1 : the mechanism of -1 frameshifting." University of Otago. Department of Biochemistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20081006.115352.

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The human immunodeficiency virus type 1 (HIV-1) uses a mechanism of genetic recoding known as programmed ribosomal frameshifting to translate the proteins encoded by the pol gene. The pol gene overlaps the preceding gag gene in the -1 reading frame relative to gag. It contains neither a start codon nor an internal ribosome entry site (IRES) to initiate translation of its proteins. Rather the host ribosomes are forced to pause due to tension placed on the mRNA when they encounter a specific secondary structural element in the mRNA. This tension is relieved by disruption of the contacts between

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Hartley, Andrew M. "Using a reprogrammed genetic code to modulate protein activity by novel post-translational control." Thesis, Cardiff University, 2014. http://orca.cf.ac.uk/68901/.

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Despite the diverse structures and functions sampled by the proteome, all proteins comprise 20 canonical amino acids that sample only a small percentage of available chemistry. This limitation is lifted somewhat through the use of post-translational modifications, however the limit imposed by the restricted number of amino acids inherently limits the variety of protein function and control that can be accessed. One powerful route to diversify the chemistry sampled by proteins is through genetically encoded unnatural amino acid (uAA) incorporation. The uAA p-azido-L-phenylalanine (AzPhe) can in

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Kelemen, Rachel Elizabeth. "New tools at the intersection of genetic code expansion, virus engineering, and directed evolution:." Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108612.

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Thesis advisor: Abhishek Chatterjee<br>In the last two decades, unnatural amino acid (UAA) mutagenesis has emerged as a powerful new method to probe and engineer protein structure and function. This technology enables precise incorporation of a rapidly expanding repertoire of UAAs into predefined sites of a target protein expressed in living cells. Owing to the small footprint of these genetically encoded UAAs and the large variety of enabling functionalities they offer, this technology has tremendous potential for deciphering the delicate and complex biology of the mammalian cells. We describ

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Schmidt, Moritz Johannes [Verfasser]. "Expanding the Genetic Code to Study the Structure and Interactions of Proteins / Moritz Johannes Schmidt." Konstanz : Bibliothek der Universität Konstanz, 2015. http://d-nb.info/1112604634/34.

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Simova, Zuzana. "Importance of single molecular determinant in bacterial tryptophanyl-tRNA synthetase fidelity in expanded genetic code." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/55120/.

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Nonnatural amino acid incorporation is a valuable method for introducing novel chemical functional groups into proteins. For this method, an orthogonal arninoacyl-tRNA synthetase (AARS) and a cognate tRNA that suppress an encoded stop codon are introduced into the cell (these components are required to be orthogonal). Nonnatural amino acids (NAAs) are usually incorporated efficiently by using <italic>Methanocaldococcus jannaschii</italic> tyrosyl-AARS/tyrosyl-tRNA pair (Mj TyrRS/A// tRNATyr) in <italic>Escherichia coli.</italic> High translation fidelity of a synthetase is achieved by site-dir

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Hart, Jennifer A. "An analysis of the primordial soup hypothesis with respect to DNA structure and the genetic code." Lynchburg, Va. : Liberty University, 1995. http://digitalcommons.liberty.edu.

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Pouyet, Fanny. "Étude bioinformatique de l'évolution de l'usage du code génétique." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1140/document.

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Le code génétique est la table de correspondance entre codons (unité structurelle d'un gène) et acides aminés (brique élémentaire des protéines). Le code génétique est (1) universel, tous les êtres vivants ou presque partagent le même code; (2) univoque, chaque codon spécifie un seul acide aminé et (3) dégénéré, les acides aminés peuvent être codés par plusieurs codons. Ce code dégénéré est donc utilisé par l'ensemble du vivant mais pas de la même manière, certains codons synonymes étant utilisés préférentiellement chez des espèces et pas d'autres. Pour comprendre l'émergence des biais d'usage

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Oliveira, Lariza Laura de. "Algoritmos evolutivos aplicados na investigação da adaptabilidade do código genético." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-24022016-144852/.

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O código genético é altamente conservado e está presente na maior parte dos organismos vivos. Uma questão que tem intrigado os cientistas é se o código genético é fruto do acaso ou de um processo evolutivo. Se qualquer associação entre aminoácidos e códons é possível, então existem cerca de 1, 51 × 1084 códigos possíveis. A hipótese de que o código genético evoluiu é suportada por sua robustez frente a mutações. Duas metodologias tem sido utilizadas para estudar esta hipótese: a abordagem estatística, que estima o número de códigos aleatórios melhores que o código genético padrão, e a abordage

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Phung, Viet-Anh. "Input Calibration, Code Validation and Surrogate Model Development for Analysis of Two-phase Circulation Instability and Core Relocation Phenomena." Doctoral thesis, KTH, Kärnkraftssäkerhet, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-202957.

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Code validation and uncertainty quantification are important tasks in nuclear reactor safety analysis. Code users have to deal with large number of uncertain parameters, complex multi-physics, multi-dimensional and multi-scale phenomena. In order to make results of analysis more robust, it is important to develop and employ procedures for guiding user choices in quantification of the uncertainties. The work aims to further develop approaches and procedures for system analysis code validation and application to practical problems of safety analysis. The work is divided into two parts. The f

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Albuquerque, Julio Cesar Holanda de. "Proposta de constelações de sinais para o codigo genetico." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/259781.

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Orientador: Reginaldo Palazzo Junior<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Eletrica e de Computação<br>Made available in DSpace on 2018-08-12T13:34:06Z (GMT). No. of bitstreams: 1 Albuquerque_JulioCesarHolandade_M.pdf: 1364323 bytes, checksum: 01181adde228aa4d914d7edabdde4aca (MD5) Previous issue date: 2008<br>Resumo: A proposta deste trabalho é apresentar uma abordagem aos processos genéticos e moleculares, utilizando a teoria de comunicações e codificação na modelagem do dogma central da biologia molecular. A partir desta modelagem associamo

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Gerding, Hanne Rieke [Verfasser]. "Site-specific incorporation of 3-nitrotyrosine in proteins generated via genetic code expansion in E.coli / Hanne Rieke Gerding." Konstanz : Bibliothek der Universität Konstanz, 2018. http://d-nb.info/1179076869/34.

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Davis, Lloyd Daniel. "The use of the orthogonal pyrrolysyl-tRNA synthetase/tRNACUA pair for further enhancement of genetic code expansion technologies." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607872.

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