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Artykuły w czasopismach na temat „Genetic Translation Study”

Autor: Grafiati

Data publikacji: 19 października 2024

Data aktualizacji: 31 lipca 2025

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1

Pleijel, Richard. "Translation teams as cognitive systems." Developments in Cognitive Translation and Interpreting Studies 8, no. 2 (2021): 307–27. http://dx.doi.org/10.1075/cogls.00080.ple.

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Abstract This paper aims to bring research on different forms of group-level cognition into conversation with Cognitive Translation Studies (CTS), the focal point of the paper being cognitive processes in translation teams. It is argued that an analysis of cognition in translation teams, which exhibit the properties of a cognitive system, needs to be placed on group-level. A case study of a team, translating the Hebrew Bible Book of Psalms into Swedish in the 1980’s, is presented. The empirical base for the case study consists of archival material in the form of draft translations and paratext

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Aryal, Sameer, Francesco Longo, and Eric Klann. "Genetic removal of p70 S6K1 corrects coding sequence length-dependent alterations in mRNA translation in fragile X syndrome mice." Proceedings of the National Academy of Sciences 118, no. 18 (2021): e2001681118. http://dx.doi.org/10.1073/pnas.2001681118.

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Loss of the fragile X mental retardation protein (FMRP) causes fragile X syndrome (FXS). FMRP is widely thought to repress protein synthesis, but its translational targets and modes of control remain in dispute. We previously showed that genetic removal of p70 S6 kinase 1 (S6K1) corrects altered protein synthesis as well as synaptic and behavioral phenotypes in FXS mice. In this study, we examined the gene specificity of altered messenger RNA (mRNA) translation in FXS and the mechanism of rescue with genetic reduction of S6K1 by carrying out ribosome profiling and RNA sequencing on cortical ly

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Carr, Jennifer F., Hannah J. Lee, Joshua B. Jaspers, Albert E. Dahlberg, Gerwald Jogl, and Steven T. Gregory. "Phenotypic Suppression of Streptomycin Resistance by Mutations in Multiple Components of the Translation Apparatus." Journal of Bacteriology 197, no. 18 (2015): 2981–88. http://dx.doi.org/10.1128/jb.00219-15.

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ABSTRACTThe bacterial ribosome and its associated translation factors are frequent targets of antibiotics, and antibiotic resistance mutations have been found in a number of these components. Such mutations can potentially interact with one another in unpredictable ways, including the phenotypic suppression of one mutation by another. These phenotypic interactions can provide evidence of long-range functional interactions throughout the ribosome and its functional complexes and potentially give insights into antibiotic resistance mechanisms. In this study, we used genetics and experimental evo

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Munandar, Siswoyo Aris, Laelatul Barokah, and Elia Malikhaturrahmah. "Analisis Genetik Objektif Afektif atas Alquran dan Terjemahnya dalam Bahasa Jawa Banyumasan." JOURNAL OF QUR'AN AND HADITH STUDIES 9, no. 2 (2020): 1–28. http://dx.doi.org/10.15408/quhas.v9i2.16892.

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The focus of the study conducted by the researcher this time is on the translator section, the product, and the public's response to the translation. As for the translator, the writer terms it with the genetic aspect, the researcher's product is the objective aspect, while the response of the research community is termed the affective aspect. So that the problem formulations built by the researcher include (1) How is the method of translating the Qur'an and its translation: Javanese Banyumasan?, (2) What is the quality of the translation of the Al-Qur'an and its translation: Javanese Banyumasa

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Shu, Xin Erica, Robert V. Swanda, and Shu-Bing Qian. "Nutrient Control of mRNA Translation." Annual Review of Nutrition 40, no. 1 (2020): 51–75. http://dx.doi.org/10.1146/annurev-nutr-120919-041411.

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The emergence of genome-wide analyses to interrogate cellular DNA, RNA, and protein content has revolutionized the study of control networks that mediate cellular homeostasis. mRNA translation represents the last step of genetic flow and primarily defines the proteome. Translational regulation is thus critical for gene expression, in particular under nutrient excess or deficiency. Until recently, it was unclear how the global effects of translational control are orchestrated by nutrient signaling pathways. An emerging concept of translational reprogramming addresses how to maintain the express

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Alghamdi, Emad A., Jezia Zakraoui, and Fares A. Abanmy. "Domain Adaptation for Arabic Machine Translation: Financial Texts as a Case Study." Applied Sciences 14, no. 16 (2024): 7088. http://dx.doi.org/10.3390/app14167088.

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Neural machine translation (NMT) has shown impressive performance when trained on large-scale corpora. However, generic NMT systems have demonstrated poor performance on out-of-domain translation. To mitigate this issue, several domain adaptation methods have recently been proposed which often lead to better translation quality than genetic NMT systems. While there has been some continuous progress in NMT for English and other European languages, domain adaption in Arabic has received little attention in the literature. The current study, therefore, aims to explore the effectiveness of domain-

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7

Ádám, Balázs, Szabolcs Lovas, and Róza Ádány. "Use of Genomic Information in Health Impact Assessment is Yet to Come: A Systematic Review." International Journal of Environmental Research and Public Health 17, no. 24 (2020): 9417. http://dx.doi.org/10.3390/ijerph17249417.

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Information generated by genetic epidemiology and genomics studies has been accumulating at fast pace, and this knowledge opens new vistas in public health, allowing for the understanding of gene–environment interactions. However, the translation of genome-based knowledge and technologies to the practice of healthcare, and especially of public health, is challenging. Because health impact assessment (HIA) proved to be an effective tool to assist consideration of health issues is sectoral policymaking, this study aimed at exploring its role in the translational process by a systematic literatur

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8

Lee, Joon-Hwa, and Masato Katahira. "Biophysical Study of the Structure, Dynamics, and Function of Nucleic Acids." International Journal of Molecular Sciences 23, no. 10 (2022): 5836. http://dx.doi.org/10.3390/ijms23105836.

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Lindberg, Nangel M., Amanda M. Gutierrez, Kathleen F. Mittendorf, et al. "Creating accessible Spanish language materials for Clinical Sequencing Evidence-Generating Research consortium genomic projects: challenges and lessons learned." Personalized Medicine 18, no. 5 (2021): 441–54. http://dx.doi.org/10.2217/pme-2020-0075.

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Aim: To increase Spanish speakers' representation in genomics research, accessible study materials on genetic topics must be made available in Spanish. Materials & methods: The Clinical Sequencing Evidence-Generating Research consortium is evaluating genome sequencing for underserved populations. All sites needed Spanish translation of recruitment materials, surveys and return of results. Results: We describe our process for translating site-specific materials, as well as shared measures across sites, to inform future efforts to engage Spanish speakers in research. Conclusion: In translati

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Liu, Yuan, and Liangfeng Dong. "Research on English Translation Based on Functional Equivalence Theory and Genetic Algorithm." Wireless Communications and Mobile Computing 2021 (January 7, 2021): 1–7. http://dx.doi.org/10.1155/2021/6672773.

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With the increasing development of our country and the world, the importance of English as an international language is self-evident. But we have difficulty in English translation, especially the vocabulary and translation of business English letters, not only because we have different living habits but also because we have different ways of speaking. Based on the research of functional equivalence theory and the calculation of a genetic algorithm, the vocabulary and translation of business English letters will be better improved. This can help us communicate better with each other and learn f

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Liu, Yuan, and Liangfeng Dong. "Research on English Translation Based on Functional Equivalence Theory and Genetic Algorithm." Wireless Communications and Mobile Computing 2021 (January 7, 2021): 1–7. http://dx.doi.org/10.1155/2021/6672773.

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With the increasing development of our country and the world, the importance of English as an international language is self-evident. But we have difficulty in English translation, especially the vocabulary and translation of business English letters, not only because we have different living habits but also because we have different ways of speaking. Based on the research of functional equivalence theory and the calculation of a genetic algorithm, the vocabulary and translation of business English letters will be better improved. This can help us communicate better with each other and learn f

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12

Groisman, Irina, and Hanna Engelberg-Kulka. "Translational bypassing: a new reading alternative of the genetic code." Biochemistry and Cell Biology 73, no. 11-12 (1995): 1055–59. http://dx.doi.org/10.1139/o95-113.

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The translation of the genetic code, once thought to be rigid, has been found to be quite flexible, and several alternatives in its reading have been described. An unusual alternative is translational bypassing, a frameshift event where the transition from frame 0 to another frame occurs by translational bypassing of an extended region of the mRNA sequence rather than by slippage past a single nucleotide, as has been described for most examples of frameshifting. Translational bypassing has been characterized in two cases, T4 gene 60 coding for a topoisomerase subunit and in a trpR–lac′Z fusion

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13

Tran, Ben, Janet E. Dancey, Suzanne Kamel-Reid, et al. "Cancer Genomics: Technology, Discovery, and Translation." Journal of Clinical Oncology 30, no. 6 (2012): 647–60. http://dx.doi.org/10.1200/jco.2011.39.2316.

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In recent years, the increasing awareness that somatic mutations and other genetic aberrations drive human malignancies has led us within reach of personalized cancer medicine (PCM). The implementation of PCM is based on the following premises: genetic aberrations exist in human malignancies; a subset of these aberrations drive oncogenesis and tumor biology; these aberrations are actionable (defined as having the potential to affect management recommendations based on diagnostic, prognostic, and/or predictive implications); and there are highly specific anticancer agents available that effecti

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14

Lee, Joon-Hwa. "New Understandings from the Biophysical Study of the Structure, Dynamics, and Function of Nucleic Acids 2.0." International Journal of Molecular Sciences 23, no. 24 (2022): 15822. http://dx.doi.org/10.3390/ijms232415822.

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Hina, S. "Translational inhibitors as potential therapeutic tool of human neuroblastoma through mitochondrial gene expression." European Psychiatry 41, S1 (2017): S464. http://dx.doi.org/10.1016/j.eurpsy.2017.01.517.

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Neuroblastoma is a solid neuroendocrine tumour and most common type of cancer of infancy. It is a complex heterogeneous disease and many factors such as molecular, cellular and genetic features are involved in its development. Mitochondria play a pivotal role in neuronal cell survival or death. Neurons are highly reliant on aerobic oxidative phosphorylation (OXPHOS) for their energy needs. Defective activities of mitochondrial complexes I, II, III and IV have been identified in many neurological and neurodegenerative diseases. Human mitochondria with its own genetic material meet the needs req

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16

Kumar, Prafulla, Sushmita, Ankit Agrawal, Abhay Kumar, and Ravindra Kumar. "Unveiling the Molecular Arsenal: NIK1-Mediated Translation Suppression as a Key Player in Plant Antiviral Immunity." Journal of Scientific Research and Reports 31, no. 4 (2025): 30–43. https://doi.org/10.9734/jsrr/2025/v31i42925.

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Plant cells are continually exposed to a variety of microbes, with viral infections standing out as a major agricultural challenge. Viruses often undermine plant defenses, posing a significant threat to the productivity of crucial crops and global food security. Plant viruses, due to their limited coding capacity, heavily rely on the host cell machinery during infection, interacting with numerous host proteins. Given the absence of translation-required components in viral genomes, plant viruses have evolved strategies to manipulate the host protein synthesis machinery for viral protein product

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17

Mustapha, Abdulsalam, Zarah Yerima Ubah Fatima, Ummi Ahmed Hasiya, Ahmed Tafida Ummulkhulthum, and Wada Nasir Aisha. "Deciphering the Genetic Code: Mechanisms, Evolution, and Implications for Biotechnology." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 858–68. https://doi.org/10.5281/zenodo.13221050.

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The study of the genetic code explores the foundational language of life, aiming to fathom how DNA orchestrates the synthesis of proteins. This study explores various facets of the genetic code, from the widespread use of the triplet codon system to the vital role of transfer RNA (tRNA) in translation. This study unravels the intricacies of interactions between codons and anticodons, as well as the orchestration of ribosomes, casting illumination on the initiation, elongation, and termination stages of protein synthesis. Furthermore, it delves into the regulatory factors and mechanisms for qua

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18

Hagen, Darren E., and Anna K. Goldkamp. "99 Noncoding Rnas Alter Our Interpretations of Genome to Phenome." Journal of Animal Science 101, Supplement_3 (2023): 52–53. http://dx.doi.org/10.1093/jas/skad281.065.

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Abstract Gene transcription and protein translation are core components in the process of gene expression. Previous research on the regulation of gene expression largely focuses on events prior to translation, including epigenetic regulation, transcription, and RNA processing. However, translation acts as an additional layer of regulation that plays an important role in gene expression and function. Highly expressed genes are thought to be codon-biased to support efficient translation, in which the encoded codons correspond to highly abundant tRNAs. Further, synonymous SNPs were once considere

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19

Dalton, Ryan P. "Shared genetic requirements for ATF5 translation in the vomeronasal organ and main olfactory epithelium." F1000Research 7 (January 17, 2018): 73. http://dx.doi.org/10.12688/f1000research.13659.1.

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Background: Both olfactory sensory neurons (OSNs) and vomeronasal sensory neurons (VSNs) require the transcription factor Atf5 for maturation and survival. In OSNs, ATF5 translation is controlled by olfactory receptor (OR) expression-mediated activation of the PERK branch of the unfolded protein response. This study evaluated whether OSNs and VSNs share genetic requirements for ATF5 translation. Methods: ATF5 immunoreactivity was assayed in whole vomeronasal organs from a series of genetic mutant animals identified in studies of OR gene choice, OR feedback, and regulation and OSN development.

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20

O’Neill, Shane. "“To Have Done Again”." Samuel Beckett Today / Aujourd’hui 33, no. 2 (2021): 337–52. http://dx.doi.org/10.1163/18757405-03302014.

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Abstract This essay is a genetic manuscript study of Beckett’s self-translation process. This study will examine how Beckett preserved the still-life attributes of Still in self-translation, and how he maintained the tension between motion and stillness in his translation of Pour finir encore. In Still, readers realise that the figure is not entirely still because of the rise and fall of its chest and the slow movement of its hand. Neither can Beckett impose stillness upon his world in Pour finir encore. By examining manuscripts, patterns of translation will emerge, giving readers a better und

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Parnell, Nathan, K. Rye, and N. Greenberg. "Health and well-being management in the military: a systematic review of genetic studies." Journal of the Royal Army Medical Corps 164, no. 4 (2017): 302–8. http://dx.doi.org/10.1136/jramc-2017-000765.

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BackgroundGenetic research may have therapeutic value for mental and physical disorders and could have an indicative or preventative capacity. Little is known about the extent, form and utility of military-specific genetic research.MethodA systematic review was conducted to evaluate existing genetic well-being studies of service personnel. The review specifically aimed to ascertain the current state of knowledge and feasibility of using genetics to aid recruitment and health management within military populations. Databases searched included MEDLINE, Embase, PsycINFO and Web of Science for rel

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Campuzano, Oscar, Anna Fernandez-Falgueras, Ximena Lemus, et al. "Short QT Syndrome: A Comprehensive Genetic Interpretation and Clinical Translation of Rare Variants." Journal of Clinical Medicine 8, no. 7 (2019): 1035. http://dx.doi.org/10.3390/jcm8071035.

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Short QT syndrome, one of the most lethal entities associated with sudden cardiac death, is a rare genetic disease characterized by short QT intervals detected by electrocardiogram. Several genetic variants are causally linked to the disease, but there has yet to be a comprehensive analysis of variants among patients with short QT syndrome. To fill this gap, we performed an exhaustive study of variants currently catalogued as deleterious in short QT syndrome according to the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Analysis of the 32 varian

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Sukmawati, Ika, and Karunia Galih Permadani. "Genetic Material Upgrading: Misconception Identification Study in High School Biology Teachers." Indonesian Journal of Biology Education 3, no. 2 (2021): 1. http://dx.doi.org/10.31002/ijobe.v3i2.3201.

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<p><em>This study aims to identify and map patterns of genetic misconceptions in high school biology teachers. This research was conducted in several stages, including the development of diagnostic test instrument with Certainty of Response Index (CRI). The instrument used in measuring misconceptions in this study is a three-tier test diagnostic instrument. There are 20 questions covering Basic Competencies 3.3, 3.5, 3.6, 3.7, and 3.8. The cognitive level of the questions covers C2 to C5 in Bloom Taxonomy. The validator's assessment shows that the instrument is suitable for data co

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Kaziev, Eduard V. "“The Secret History of the Mongols”: compilation, study of the literary monument and the information on the Alans it contains." Vestnik of North Ossetian State University, no. 4 (December 25, 2024): 50–56. https://doi.org/10.29025/1994-7720-2024-4-50-56.

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The purpose of the study is to present the relationship between the structural features of the chronicle “The Secret History of the Mongols” and the history of its compilation by Mongolian historiographers and the history of its use in the Chinese historiographic tradition. The relevance of the study is determined by the obscure of these aspects for researchers of medieval Alanian history, which falls during the period of the Mongol Eurasian expansion. The result of the study is the general conclusion that the only complete Russian-language translation of the chronicle available today, present

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Perriera, Riccardo, Emanuele Vitale, Ivana Pibiri, et al. "Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression." International Journal of Molecular Sciences 24, no. 20 (2023): 15084. http://dx.doi.org/10.3390/ijms242015084.

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Nonsense mutations cause several genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, β-thalassemia, and Shwachman–Diamond syndrome. These mutations induce the formation of a premature termination codon (PTC) inside the mRNA sequence, resulting in the synthesis of truncated polypeptides. Nonsense suppression therapy mediated by translational readthrough-inducing drugs (TRIDs) is a promising approach to correct these genetic defects. TRIDs generate a ribosome miscoding of the PTC named “translational readthrough” and restore the synthesis of full-length and potentially functio

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Osherov, Nir, and Gregory May. "Conidial Germination in Aspergillus nidulans Requires RAS Signaling and Protein Synthesis." Genetics 155, no. 2 (2000): 647–56. http://dx.doi.org/10.1093/genetics/155.2.647.

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Abstract The dormant spores of Aspergillus nidulans become competent for growth and nuclear division in a process called conidial germination. To analyze the molecular details of conidial germination, we developed a genetic screen in which we identified spore germination-deficient mutants that are blocked in this process at the restrictive temperature. These mutants defined eight genes, of which we identified five. Four of the five were directly involved in translation and protein folding, and the fifth showed a high degree of homology to a malonyl CoA synthetase. These results suggest that ou

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Mustapha Abdulsalam, Fatima Zarah Yerima Ubah, Hasiya Ummi Ahmed, Ummulkhulthum Ahmed Tafida, and Aisha Wada Nasir. "Deciphering the Genetic Code: Mechanisms, Evolution, and Implications for Biotechnology." World Journal of Advanced Research and Reviews 21, no. 1 (2024): 858–68. http://dx.doi.org/10.30574/wjarr.2024.21.1.2195.

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The study of the genetic code explores the foundational language of life, aiming to fathom how DNA orchestrates the synthesis of proteins. This study explores various facets of the genetic code, from the widespread use of the triplet codon system to the vital role of transfer RNA (tRNA) in translation. This study unravels the intricacies of interactions between codons and anticodons, as well as the orchestration of ribosomes, casting illumination on the initiation, elongation, and termination stages of protein synthesis. Furthermore, it delves into the regulatory factors and mechanisms for qua

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Lin, Jin, Chuan He, Shuang Shi, and Jiongfeng Song. "Heterogeneous isomorphism - Spatial Gene Transcreation Design for Traditional Villages in Hunan." SHS Web of Conferences 167 (2023): 02016. http://dx.doi.org/10.1051/shsconf/202316702016.

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This study analyzes the spatial genes of traditional villages by taking Zhang Guying village in northern Hunan Province as an example.Starting from the theory of heterogeneous isomorphism, we discover the methods and paths of identifying, presenting and translating the spatial genes of traditional villages in Hunan region.Through the gene identification extraction method, it analyzes the spatial and cultural genes of Zhang Guying village and obtains the genetic elements and composition of the traditional villages.Based on the design model of gene translation, the “Duanwu family” is systematica

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Vargas-Rodriguez, Oscar, Ahmed H. Badran, Kyle S. Hoffman, et al. "Bacterial translation machinery for deliberate mistranslation of the genetic code." Proceedings of the National Academy of Sciences 118, no. 35 (2021): e2110797118. http://dx.doi.org/10.1073/pnas.2110797118.

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Inaccurate expression of the genetic code, also known as mistranslation, is an emerging paradigm in microbial studies. Growing evidence suggests that many microbial pathogens can deliberately mistranslate their genetic code to help invade a host or evade host immune responses. However, discovering different capacities for deliberate mistranslation remains a challenge because each group of pathogens typically employs a unique mistranslation mechanism. In this study, we address this problem by studying duplicated genes of aminoacyl-transfer RNA (tRNA) synthetases. Using bacterial prolyl-tRNA syn

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Su, Songtao, Hailong Hu, Kang Liu, et al. "Comparative analysis of translatomics and transcriptomics in the longissimus dorsi muscle of Luchuan and Duroc pigs." PLOS ONE 20, no. 3 (2025): e0319399. https://doi.org/10.1371/journal.pone.0319399.

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IMF (Intramuscular fat) content is a crucial indicator of meat quality in the livestock industry. However, the molecular mechanisms underlying IMF deposition remain unclear in pigs. In this study, we conducted RNC-seq (ribosome nascent-chain complex-bound RNA sequencing) and RNA-seq (RNA sequencing) analyses on the longissimus dorsi muscle of Duroc pigs (a lean breed) and Luchuan pigs (a fat breed) to uncover the genetic basis for the divergent IMF content. The results show that the overall translation level of Luchuan pigs is significantly higher than Duroc pigs, while there is no significant

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Zhu, Ping Jun, Sanjeev Khatiwada, Ya Cui, et al. "Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome." Science 366, no. 6467 (2019): 843–49. http://dx.doi.org/10.1126/science.aaw5185.

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Down syndrome (DS) is the most common genetic cause of intellectual disability. Protein homeostasis is essential for normal brain function, but little is known about its role in DS pathophysiology. In this study, we found that the integrated stress response (ISR)—a signaling network that maintains proteostasis—was activated in the brains of DS mice and individuals with DS, reprogramming translation. Genetic and pharmacological suppression of the ISR, by inhibiting the ISR-inducing double-stranded RNA–activated protein kinase or boosting the function of the eukaryotic translation initiation fac

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Andrecut, M., and S. A. Kauffman. "Noise in Genetic Toggle Switch Models." Journal of Integrative Bioinformatics 3, no. 1 (2006): 63–77. http://dx.doi.org/10.1515/jib-2006-23.

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Summary In this paper we study the intrinsic noise effect on the switching behavior of a simple genetic circuit corresponding to the genetic toggle switch model. The numerical results obtained from a noisy mean-field model are compared to those obtained from the stochastic Gillespie simulation of the corresponding system of chemical reactions. Our results show that by using a two step reaction approach for modeling the transcription and translation processes one can make the system to lock in one of the steady states for exponentially long times.

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Asl, Samaneh Noroozi, Rahim Vakili, Saba Vakili, et al. "Wolcott-Rallison syndrome in Iran: a common cause of neonatal diabetes." Journal of Pediatric Endocrinology and Metabolism 32, no. 6 (2019): 607–13. http://dx.doi.org/10.1515/jpem-2018-0434.

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Abstract Background Wolcott-Rallison syndrome is a rare autosomal recessive disorder characterized by neonatal/early-onset non-autoimmune insulin-dependent diabetes, multiple epiphyseal dysphasia and growth retardation. It is caused by mutations in the gene encoding eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3). We aimed to study the clinical characteristics and frequency of the disease in the Iranian population. Methods We recruited 42 patients who referred to the endocrine and metabolism clinic at Mashhad Imam Reza Hospital with neonatal diabetes. Molecular screening of KCNJ

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Nödling, Alexander R., Luke A. Spear, Thomas L. Williams, Louis Y. P. Luk, and Yu-Hsuan Tsai. "Using genetically incorporated unnatural amino acids to control protein functions in mammalian cells." Essays in Biochemistry 63, no. 2 (2019): 237–66. http://dx.doi.org/10.1042/ebc20180042.

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Abstract Genetic code expansion allows unnatural (non-canonical) amino acid incorporation into proteins of interest by repurposing the cellular translation machinery. The development of this technique has enabled site-specific incorporation of many structurally and chemically diverse amino acids, facilitating a plethora of applications, including protein imaging, engineering, mechanistic and structural investigations, and functional regulation. Particularly, genetic code expansion provides great tools to study mammalian proteins, of which dysregulations often have important implications in hea

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Dhar, Suparna, and Sourish Ghosh. "Innate Immune Sensors Spying Microbial Hideouts! OAS1 - ‘Stalwart Defender’ or ‘Hidden Enemy’?" Journal of Cellular Immunology 6, no. 5 (2024): 231–35. https://doi.org/10.33696/immunology.6.210.

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OAS1 plays a critical role in host-pathogen interactions by balancing translational shutdown to limit microbial replication while producing antimicrobial components. Host RNA sensors detect microbial nucleic acids, initiating an interferon-mediated innate immune response that induces ISGs to inhibit replication and shape adaptive immunity. OAS1 enhances the translation of selective mRNAs, producing proteins with antimicrobial properties. During infections, OAS1, induced by interferons, identifies viral RNA, and responds to viruses that replicate within modified organelles. Genetic polymorphism

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Sharonov, Alexander M., and Elena A. Sharonova. "Bilingualism in the Author’s Translation of the National Epic: on the Material of “Mastorava”." Polylinguality and Transcultural Practices 20, no. 2 (2023): 298–311. http://dx.doi.org/10.22363/2618-897x-2023-20-2-298-311.

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In 1994, the Erzya epic “Mastorava” was published in the Erzya language. The success of this work made us think about the need for its translation into Russian. It was decided to entrust the translation to the author of “Mastorava” - Alexander Markovich Sharonov, who is equally fluent in Erzya and Russian. The relevance of the study is determined by the enduring interest in the phenomenon of bilingualism in the author’s translation of the national epic. A bilingual poet translating his own text is in a more difficult situation than a poet translating interlinear. For the former, hearing the mu

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Bhat, Ajay, Rahul Chakraborty, Khushboo Adlakha, Ganesh Agam, Kausik Chakraborty, and Shantanu Sengupta. "Ncl1-mediated metabolic rewiring critical during metabolic stress." Life Science Alliance 2, no. 4 (2019): e201900360. http://dx.doi.org/10.26508/lsa.201900360.

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Nutritional limitation has been vastly studied; however, there is limited knowledge of how cells maintain homeostasis in excess nutrients. In this study, using yeast as a model system, we show that some amino acids are toxic at higher concentrations. With cysteine as a physiologically relevant example, we delineated the pathways/processes that are altered and those that are involved in survival in the presence of elevated levels of this amino acid. Using proteomics and metabolomics approach, we found that cysteine up-regulates proteins involved in amino acid metabolism, alters amino acid level

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Clapp, Averill, Carrie J. Shawber, and June K. Wu. "Pathophysiology of Slow-Flow Vascular Malformations: Current Understanding and Unanswered Questions." Journal of Vascular Anomalies 4, no. 3 (2023): e069. http://dx.doi.org/10.1097/jova.0000000000000069.

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Background: Slow-flow vascular malformations include venous, lymphatic, and lymphaticovenous malformations. Recent studies have linked genetic variants hyperactivating either the PI3K/AKT/mTOR and/or RAS/RAF/MAPK signaling pathways with slow-flow vascular malformation development, leading to the use of pharmacotherapies such as sirolimus and alpelisib. It is important that clinicians understand basic and translational research advances in slow-flow vascular malformations. Methods: A literature review of basic science publications in slow-flow vascular malformations was performed on Pubmed, usi

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Oshanova, E. S. "ON THE PROBLEM OF TRANSLATION “TRANSLATER’S FALSE FRIENDS” ON THE EXAMPLE OF PUBLICISTIC TEXTS." Social’no-ekonomiceskoe upravlenie: teoria i praktika 17, no. 3 (2021): 121–26. http://dx.doi.org/10.22213/2618-9763-2021-2-121-126.

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This article is devoted to the study of the interlanguage phenomenon “false friends of the translator” problems in the practice of translation studies. It is widely known that translation plays a large and important role in the cultural development of mankind. During the translation, a large number of problems arise which are quite difficult to cope with, therefore, in order to achieve the goal - to give a full and high-quality translation, the translator needs to possess versatile and special knowledge. The relevance of this work is that the concept “false friends of the translator” is consid

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Gataullina, Veronika Lyubimovna, and Nataliya Gennadyevna Nikolaeva. "Pre-metric units of length in the works of Russian and German writers and their translation." Philology. Issues of Theory and Practice 16, no. 12 (2023): 4226–32. http://dx.doi.org/10.30853/phil20230643.

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The aim of the study is to typologize the translation of the names of pre-metric units of length in Russian and German fiction by identifying common semantic transformations. The scientific novelty of the study lies in examining pre-metric units of length in the genetic, semantic and functional aspects. At the genetic level, the role of the anthropometric factor in the formation of such names is confirmed. At the semantic level, the commonality of transformational processes in the history of education and functioning of the vocabulary under consideration is investigated. At the functional leve

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Ong, Cheryl Siow Bin, Rose Wai‑Yee Fok, Ryo Chee Ann Tan, Si Ming Fung, Shirley Sun, and Joanne Yuen Yie Ngeow. "General practitioners’ (GPs) experience, attitudes and needs on clinical genetic services: a systematic review." Family Medicine and Community Health 10, no. 4 (2022): e001515. http://dx.doi.org/10.1136/fmch-2021-001515.

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ObjectiveThe proliferation and growing demands of genetic testing are anticipated to revolutionise medical practice. As gatekeepers of healthcare systems, general practitioners (GPs) are expected to play a critical role in the provision of clinical genetic services. This paper aims to review existing literature on GPs’ experience, attitudes and needs towards clinical genetic services.DesignA systematic mixed studies review of papers published between 2010 and 2022.Eligibility criteriaThe inclusion criterion was peer-reviewed articles in English and related to GPs’ experience, views and needs o

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Herlina, Lina, Reflinur Reflinur, Sobir Sobir, Awang Maharijaya, Suryo Wiyono, and Bonjok Istiaji. "GENETIC DIVERSITY OF INDONESIAN SHALLOTS BASED ON BULB-TUNIC PATTERNS AND MORPHOLOGICAL CHARACTERS." Indonesian Journal of Agricultural Science 20, no. 1 (2019): 19. http://dx.doi.org/10.21082/ijas.v20n1.2019.p19-28.

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<p class="abstrakinggris"><span class="tlid-translation">Variation within bulb tunics has been used to determine the genetic diversity in <em>Allium</em> species, including shallots</span><span class="tlid-translation"><span>. </span></span>However, no such study has been reported for shallots of Indonesia. The study aimed to analyze the genetic diversity of the Indonesian shallots based on the bulb-tunic patterns. Thirty-five shallot genotypes from main production centers in Indonesia were used. The ultrasculptures of the bulb tunics were

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Wang, Chuande, Lina Lezhneva, Nadège Arnal, Martine Quadrado, and Hakim Mireau. "The radish Ogura fertility restorer impedes translation elongation along its cognate CMS-causing mRNA." Proceedings of the National Academy of Sciences 118, no. 35 (2021): e2105274118. http://dx.doi.org/10.1073/pnas.2105274118.

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The control of messenger RNA (mRNA) translation has been increasingly recognized as a key regulatory step for gene control, but clear examples in eukaryotes are still scarce. Nucleo-cytoplasmic male sterilities (CMS) represent ideal genetic models to dissect genetic interactions between the mitochondria and the nucleus in plants. This trait is determined by specific mitochondrial genes and is associated with a pollen sterility phenotype that can be suppressed by nuclear genes known as restorer-of-fertility (Rf). In this study, we focused on the Ogura CMS system in rapeseed and showed that reve

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Yoshida, Akiko, Tomoharu Tokutomi, Akimune Fukushima, et al. "Japanese Translation and Validation of Genomic Knowledge Measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK)." Genes 14, no. 4 (2023): 814. http://dx.doi.org/10.3390/genes14040814.

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Knowledge of genetics is essential for understanding the results of genetic testing and its implications. Recent advances in genomic research have allowed us to predict the risk of onset of common diseases based on individual genomic information. It is anticipated that more people will receive such estimates of risks based on their genomic data. However, currently, there is no measure for genetic knowledge that includes post-genome sequencing advancements in Japan. In this study, we translated the genomic knowledge measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK)

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Nurse, Jalisa, Aubee Joseph, and Karl M. Thompson. "444 Post-translational role of RNA modifications in sRNA chaperone Hfq." Journal of Clinical and Translational Science 6, s1 (2022): 88. http://dx.doi.org/10.1017/cts.2022.260.

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OBJECTIVES/GOALS: The goal of this study is to determine the role of the tRNA modifications in the translation of Hfq. Hfq is an RNA chaperone that acts as a co-factor for the action of the largest class of small RNAs in E. coli. RNA modifications have been known to play critical roles in the translational fidelity of many cellular proteins in bacteria. METHODS/STUDY POPULATION: In this study, we used an hfq-lacZ translation fusion to screen several RNA modification mutant genes to uncover additional RNA modifications that may play a role in Hfq translation. We measured hfq-lacZ activity in ge

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Ueguchi, Chiharu, Naoko Misonou, and Takeshi Mizuno. "Negative Control of rpoS Expression by Phosphoenolpyruvate:Carbohydrate Phosphotransferase System inEscherichia coli." Journal of Bacteriology 183, no. 2 (2001): 520–27. http://dx.doi.org/10.1128/jb.183.2.520-527.2001.

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ABSTRACT The ςS (or ς38) subunit of RNA polymerase, encoded by the rpoS gene, is a crucial regulator in the transcriptional control of a set of genes under stressful conditions, such as nutrient starvation. The expression ofrpoS is regulated in a complex manner at the levels of transcription, translation, and stability of the product. Although a number of factors involved in the regulation of rpoSexpression have been identified, the underlying molecular mechanisms are not fully understood. In this study, we identified the Crr (or EIIAGlc) protein as a novel factor that plays an important role

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Yartseva, A., R. Devillers, H. Klaudel, and F. Képès. "From MIN model to ordinary differential equations." Journal of Integrative Bioinformatics 4, no. 3 (2007): 15–26. http://dx.doi.org/10.1515/jib-2007-61.

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Summary Biological interaction networks can be modeled using the Modular Interaction Network (MIN) formalism, which provides an intermediary modeling level between the biological and mathematical ones. MIN focuses on a simple but structured and versatile representation of biological knowledge, without targeting a particular analysis or simulation technique. In this paper, we propose a translation procedure which, starting from a MIN specification of a biological system, generates its representation in ordinary differential equations (ODEs) allowing to study the dynamics of the system. The tran

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Amato, Russell, Nicole M. Del Toro-Pagan, Harris Nguyen, et al. "Assessing the Impact of Simplified Language on a Patient-Facing Pharmacogenetic Report: A User Comprehension Study." Journal of Personalized Medicine 15, no. 6 (2025): 247. https://doi.org/10.3390/jpm15060247.

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Background: Pharmacogenetics (PGx) is the science of assessing how genetic variation affects drug efficacy, tolerability, and safety. While PGx is an emerging discipline which is becoming standard of care, many providers have misunderstandings about its utility. This is even more of a problem for patients, who may perceive that there is a single drug that is “right” for them. The primary objective of this study was to evaluate consumer comprehension of a newly developed patient-facing PGx report. Methods: In this study, we adapted a commercial pharmacogenetic test (Genomind Professional PGx) i

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Saurer, Martin, Marc Leibundgut, Hima Priyanka Nadimpalli, et al. "Molecular basis of translation termination at noncanonical stop codons in human mitochondria." Science 380, no. 6644 (2023): 531–36. http://dx.doi.org/10.1126/science.adf9890.

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The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations from the standard genetic code, including the reassignment of two arginine codons to stop codons. The protein required for translation termination at these noncanonical stop codons to release the newly synthesized polypeptides is not currently known. In this study, we used gene editing and ribosomal profiling in combination with cryo–electron microscopy to establish that mitochondrial release factor 1 (mtRF1) d

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Alonso, Lorena, Ignasi Morán, Cecilia Salvoro, and David Torrents. "In Search of Complex Disease Risk through Genome Wide Association Studies." Mathematics 9, no. 23 (2021): 3083. http://dx.doi.org/10.3390/math9233083.

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The identification and characterisation of genomic changes (variants) that can lead to human diseases is one of the central aims of biomedical research. The generation of catalogues of genetic variants that have an impact on specific diseases is the basis of Personalised Medicine, where diagnoses and treatment protocols are selected according to each patient’s profile. In this context, the study of complex diseases, such as Type 2 diabetes or cardiovascular alterations, is fundamental. However, these diseases result from the combination of multiple genetic and environmental factors, which make

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