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Rozprawy doktorskie na temat „Genetic variation”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 25 lipca 2025

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1

Walker, Tina Kay. "Genetic variation in schistosomes." Thesis, Brunel University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278245.

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Gresham, David J. "Genetic variation and disease in the Roma (Gypsies)." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2001. https://ro.ecu.edu.au/theses/1516.

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The Roma (Gypsies) are a European people composed of a mosaic of culturally heterogeneous populations. Linguistic analyses point to their origins in the Indian subcontinent. Cultural diversity in extant Romani populations suggests that they are descended from a mixture of Indian populations. Previous population genetic studies of the Roma have supported this claim by demonstrating the genetic heterogeneity of Romani populations. More recently, medical genetic research has detected identical founder mutations in separated Romani populations, which provides evidence of their relatedness. In this
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3

Vetayasuporn, Sopit. "Genetic variation in Pinus kesiya." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301651.

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Wright, Dominic. "Genetic variation in zebrafish behaviour." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414510.

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Keightley, Peter D. "Studies of quantitative genetic variation." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/12340.

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Yang, Ian Anthony. "Genetic variation in COPD pathogenesis /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16860.pdf.

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7

De, Bustos Cecilia. "Genetic and Epigenetic Variation in the Human Genome : Analysis of Phenotypically Normal Individuals and Patients Affected with Brain Tumors." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6629.

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8

Zhou, Huitong. "Genetic variation in Dichelobacter nodosus Fimbriae." Lincoln University, 2001. http://hdl.handle.net/10182/2244.

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Footrot is a contagious hoof disease of ruminants. It is endemic in New Zealand and throughout sheep and goat farming regions of the world. The disease results from a mixed bacterial infection, but the essential agent is Dichelobacter nodosus, a Gram-negative, anaerobic bacterium that possesses type-IV fimbriae on its surface. Genetic variation in the fimbriae of D. nodosus was investigated in this study. Using the polymerase chain reaction (PCR), the variable region of the gene encoding the fimbrial subunit (fimA) was amplified from bacterial DNA extracted from footrot lesions. Different fim
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9

Gannett, Lisa Anne. "Genetic variation, difference, deviation, or deviance?" Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape15/PQDD_0023/NQ31121.pdf.

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10

Lindroos, Katarina. "Accessing Genetic Variation by Microarray Technology." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5251-5/.

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11

Oballa, Phanuel O. "Genetic variation within Acacia karroo Hayne." Thesis, University of Oxford, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334928.

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12

Martinson, Jeremy James. "Genetic variation in South Pacific Islanders." Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293422.

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13

Thakur, Ajay. "Genetic variation of Juglans regia L." Thesis, Bangor University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431492.

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14

Buck, Emily Jane. "Genetic variation of Castanea sativa Mill." Thesis, Bangor University, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428823.

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15

Patel, Tulsi. "Investigating genetic variation in Alzheimer's disease." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/52447/.

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Alzheimer's disease (AD) is the most common form of dementia, now the leading cause of death in the UK, which affects more than 35 million people worldwide. Genome-wide association studies identified 20 genetic loci associated with disease susceptibility, however these only exerted small effects on risk. Next-generation sequencing is now being employed to identify more of the missing heritability. This project utilised whole-exome sequencing to explore genetic variation using the Brains for Dementia Research (BDR) resource, a well-characterised cohort of neuropathologically confirmed samples.
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16

Stewart, John E. B. (John Edward Bakos). "Genetic Variation in a Population of the Plains Woodrat Neotoma micropus." Thesis, University of North Texas, 1988. https://digital.library.unt.edu/ark:/67531/metadc500709/.

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Neotoma micropus from Jack County, Texas, were studied over a 9-month period. Loci from blood and saliva were used to determine genetic variation within the population. Deviations from Hardy-Weinberg equilibrium were found at one locus. The average temporal F over all seven loci was 0.040. Genetic structuring was subtle, fluctuated on a seasonal basis, and was due to differential migration or predation on genotypes. Heterozygotes tended to move more than homozygotes, and a greater proportion of heterozygotes were lost from the population during each season. Genetic variation was maintained in
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17

Loh, Yong-Hwee Eddie. "Genetic variation in fast-evolving East African cichlid fishes: an evolutionary perspective." Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/41148.

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Cichlid fishes from the East African Rift lakes Victoria, Tanganyika and Malawi represent a preeminent example of replicated and rapid evolutionary radiation. In this single natural system, numerous morphological (eg. jaw and tooth shape, color patterns, visual sensitivity), behavioral (eg. bower-building) and physiological (eg. development, neural patterning) phenotypes have emerged, much akin to a mutagenic screen. This dissertation encompasses three studies that seek to decipher the underpinnings of such rapid evolutionary diversification, investigated via the genetic variation in East Afri
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18

Goropashnaya, Anna. "Phylogeographic Structure and Genetic Variation in Formica Ants." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3803.

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19

Gunn, Melissa Rose School of Biological Earth &amp Environmental Science UNSW. "The use of microsatellites as a surrogate for quantitative trait variation in conservation." Awarded by:University of New South Wales. School of Biological, Earth and Environmental Science, 2003. http://handle.unsw.edu.au/1959.4/22457.

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Conservation biologists are interested in maintaining genetic variation in small populations, with a view to maintaining fitness and the ability of the species to adapt to changing environmental conditions. The most important type of genetic variation is therefore that which affects fitness and reproduction, and is therefore subject to natural selection. Such fitness traits are often quantitative, i.e. are the result of a suite of loci, and are continuously variable. Microsatellite markers are a popular method of determining the level of variation present in a species??? genome. The assumption
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20

Shringarpure, Suyash. "Statistical Methods for studying Genetic Variation in Populations." Research Showcase @ CMU, 2012. http://repository.cmu.edu/dissertations/117.

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The study of genetic variation in populations is of great interest for the study of the evolutionary history of humans and other species. Improvement in sequencing technology has resulted in the availability of many large datasets of genetic data. Computational methods have therefore become quite important in analyzing these data. Two important problems that have been studied using genetic data are population stratification (modeling individual ancestry with respect to ancestral populations) and genetic association (finding genetic polymorphisms that affect a trait). In this thesis, we develop
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21

Roussos, Athanasios. "Morphological variation, population genetics and genetic relatedness in three species of Callopora." Thesis, Swansea University, 2007. https://cronfa.swan.ac.uk/Record/cronfa42590.

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The genus Callopora is typical of a very large number of encrusting neocheilostomate genera and can be used to demonstrate the range of autozooid morphology seen in the group. Morphometric analyses of zooid length (ZL), zooid width (ZW), ovicell length (OL) and ovicell width (OW) were conducted in order to study morphological variation in different populations of Callopora dumerilii, Callopora lineata and CaUopora rylandi and to partition the morphological variation within and between sites and colonies for each species using a nested analysis of variance and a principal component analysis app
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22

Whiteley, Rachel. "Quantitative and molecular genetic variation in Ulmus laevis Pall. /." Uppsala : Dept. of Plant Biology and Forest Genetics, Swedish Univ. of Agricultural Sciences, 2004. http://epsilon.slu.se/s313.pdf.

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23

Larsson, Jobs Karl. "Population Fragmentation and Genetic Variation in Grouse." Doctoral thesis, Uppsala University, Department of Ecology and Evolution, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-6006.

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<p>In this thesis the genetic variation of two grouse species, the Chinese grouse (<i>Bonasa sewersowi</i>) and the Black grouse (<i>Tetrao tetrix</i>) was examined with neutral genetic markers: microsatellites. Habitat fragmentation and isolation leads to structuring among and loss of genetic variation within populations.</p><p>The Chinese grouse in a small population in Lianhuasan nature reserve was found to have undergone a population bottleneck and as a result of isolation and possible inbreeding showed genetic impoverishment hereof.</p><p>The Black grouse populations in Europe face variou
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24

Davies, Robert William. "Factors influencing genetic variation in wild mice." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:ced6a42f-66f5-4001-aaf8-8059d5fcfe27.

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The mouse is a premier model organism for mammalian biological research. They have been instrumental in studies illuminating processes of fundemental importance to genetics including the control of recombination and the process of speciation. However, most of these studies are based on laboratory mice, which are an artificial population with a complex relationship to wild mice. Studies of mammalian biology would benefit from understanding how history has shaped the genome of the present day mouse. In this thesis, I explore factors that contribute to patterns of genetic variation in wild mice,
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25

Mizzen, Craig A. "Genetic and epigenetic variation in histone H1." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ58638.pdf.

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26

Bancroft, David. "Genetic variation and fitness in Soay sheep." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338112.

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27

Shihab, Hashem Ali. "Predicting the functional effects of genetic variation." Thesis, University of Bristol, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.633144.

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Elucidation of the functional effects of genetic variation within the human genome has the potential to improve our understanding of the molecular mechanisms underlying a plethora of human diseases, as well as leading onto novel diagnostic and therapeutic markers. Technological advances in next-generation sequencing technologies, coupled with the falling costs in whole-genome/ whole-exome sequencing technologies, have led to an explosion of variants being identified for which the functional consequence is unknown. However, characterizing functional variants through lab-based validation has now
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28

Li, Yinglei. "Genetic Association Testing of Copy Number Variation." UKnowledge, 2014. http://uknowledge.uky.edu/statistics_etds/8.

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Copy-number variation (CNV) has been implicated in many complex diseases. It is of great interest to detect and locate such regions through genetic association testings. However, the association testings are complicated by the fact that CNVs usually span multiple markers and thus such markers are correlated to each other. To overcome the difficulty, it is desirable to pool information across the markers. In this thesis, we propose a kernel-based method for aggregation of marker-level tests, in which first we obtain a bunch of p-values through association tests for every marker and then the ass
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29

Strittmatter, Laura Anne. "Linking Human Genetic Variation to Mitochondrial Metabolism." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11428.

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Genetic variation has a powerful impact on human metabolism and disease. Traditionally, this relationship has either been studied at a high level using top-down descriptive studies of patients with genetically defined inborn errors of metabolism, or else from the bottom up, with molecular biology and biochemical studies of single proteins. Recent advances in genetic sequencing, metabolic profiling technology, and structural biology are rapidly enabling the integration of these approaches towards a more complete description of human metabolism.
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30

Detsika, Maria G. "Genetic variation amongst isolates of Burkholderia cepacia." Thesis, University of Liverpool, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269724.

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31

Neilson, Tracey C. S. "Genetic characterisation and variation in Gyrodactylus species." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421353.

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The main focus of this investigation here involved three of the four most common salmonid <i>Gyrodactylus </i>species (<i>G. salarism G. thymalli, G. derjavini </i>and <i>G. truttae</i>), with particular attention to discriminating between <i>G. salaris </i>and <i>G. thymalli</i>.  This was accomplished by characterising uncharacterised areas of the genome, i.e. the intergenic spacer region and 28S subunit of the ribosomal array, and CO1 and ND1 gene regions of the mitochondrial genome.  Once characterisation was completed for these species, the more variable regions that would potentially be
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32

Cesarini, David Alexander. "Essays on genetic variation and economic behavior." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/57897.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Economics, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>This thesis is a collection of papers in which behavior genetic methods are used to shed light on individual differences in economic preferences, behaviors and outcomes. Chapter one uses the classical twin design to provide estimates of genetic and environmental influences on experimentally elicited preferences for risk and giving. The paper reports evidence that these preferences are broadly heritable, with estimates suggesting t
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Noori, Muhammad Yahya. "Genetic variation and virulence of Streptococcus pneumoniae." Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4440/.

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Streptococcus pneumoniae or pneumococcus is included among major human pathogens and is responsible for a number of diseases including life-threatening conditions such as pneumonia, meningitis and sepsis. Though pneumococcal vaccines are available, they provide limited coverage against infections as pneumococcus shows extensive variation, which also allows escape from vaccines and antibiotic resistance. It is armed with several virulence factors including capsule, surface proteins, enzymes and toxins, which are variably expressed and altogether determine pneumococcal virulence. The aim of this
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Groves-Kirkby, Nick. "Genetic analysis of variation in complex traits." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:4541c4e4-4538-4348-bb4b-0df6673344d2.

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Variation is a universal property of life, and much of contemporary genetics research is directed towards understanding the causes of variation in traits. Here I present the results of my investigations into the genetic and other causes of trait variation in humans and mice. I address these questions in the context of two distinct research projects, which use pre-existing data to investigate the causes of trait variation, through a range of analytic techniques. I first extract trait data from historic breeding records from the incipient Collaborative Cross (a genetic reference population of re
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Johnson, Paul Christopher Duncan. "Genetic variation in the aphid Pemphigus spyrothecae." Thesis, University of Cambridge, 2000. https://www.repository.cam.ac.uk/handle/1810/269526.

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This project used genetic variation to investigate dispersal, inbreeding and social behaviour in the aphid Pemphigus spyrothecac. P. spyrothecae is cyclically parthenogenetic, reproducing sexually on the bark of its primary host, Populus nigra, and asexually within galls on the leaf petioles. Within the gall, a soldier caste defends and cleans the gall, potentially reducing its own fitness. P. spyrothecae collected across the UK from 1997 to 1999 and from mainland Europe and America in 1999 were genotyped using seven variable microsatellite markers that I developed in collaboration with Willia
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36

Tavera, Gloria. "Helicobacter pylori Genetic Variation and Gastric Disease." Case Western Reserve University School of Graduate Studies / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=case1565176211647636.

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Donahoo, Ryan Scott. "Genetic variation in Xanthomonas axonopodis pv. dieffenbachiae." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0000676.

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Dastgheib, Alireza. "The role of genetic variation in osteoporosis." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/9972/.

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Archer, Jason Allan. "Genetic variation in the efficiency of feed utilisation by animals." Title page, table of contents and abstract only, 1996. http://web4.library.adelaide.edu.au/theses/09PH/09pha6711.pdf.

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Bibliography: leaves 186-200. Analyses feed intake and growth data from cattle, which indicates that genetic variation exists in post-weaning effiency and growth. Concludes with a consideration of how post-weaning feed intake information can be used in genetic improvement programs.
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Rogell, Björn. "Genetic variation and local adaptation in peripheral populations of toads." Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107395.

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Rowell, Jennie Lynn. "GENETIC VARIATION IN THE DOMESTICATED DOG AS A MODEL OF HUMAN DISEASE." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1338237356.

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42

Olsson, Jenny. "Genetic diversity and hardiness in Scots pine from Scandinavia to Russia." Thesis, Umeå universitet, Institutionen för ekologi, miljö och geovetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-160222.

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The postglacial recolonization of northern Europe supposedly originated from Western Europe and the Russian Plain, however, recent molecular and macrofossil-based investigations suggest that the history may be more complex than previously thought. This study aims to investigate the genetic diversity and population structure of Scots pine from Scandinavia to Russia to re-evaluate its recolonization history, and to examine whether the pattern of spatial genetic diversity has any adaptive significance. Populations ranging from Norway to Russia were sampled and genotyped using genotyping-by-sequen
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Benavides, Lucille H. "Genetic variation in the eastern subterranean termite Reticulitermes flavipes (Isoptera: Rhinotermitidae)." Texas A&M University, 2004. http://hdl.handle.net/1969.1/3319.

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The eastern subterranean termite, Reticulitermes flavipes, is the most widely dispersed termite in North America. The genus Reticulitermes spp. is responsible for 80% of total termite damage caused to urban structures each year. Little is known about the genetic structure of termites, particularly at the colony level. Evidence for what genetically defines a termite colony is a hotly debated topic in current literature due to the implications such findings would have regarding current lawsuits against pest control operations. Information on termite genetic structure is sparse. In this study, t
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44

King, Rachel, and n/a. "Spatial Structure and Population Genetic Variation in a Eucalypt Species Complex." Griffith University. Australian School of Environmental Studies, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20050113.091713.

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In this study, the relative influences of selection, gene flow, and other evolutionary forces on the spatial structure of genetic variation within a eucalypt species complex (the spotted gums: genus Corymbia, section Politaria) were assessed. The study investigated the spatial genetic structure among four putative species of spotted gum (broad-scale), as well as within a single population (fine-scale)of one species, using both molecular and quantitative markers. The spotted gum complex occurs naturally across a range of 2500 km in eastern Australia. Spatial genetic variation within and between
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King, Rachel. "Spatial Structure and Population Genetic Variation in a Eucalypt Species Complex." Thesis, Griffith University, 2004. http://hdl.handle.net/10072/365496.

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In this study, the relative influences of selection, gene flow, and other evolutionary forces on the spatial structure of genetic variation within a eucalypt species complex (the spotted gums: genus Corymbia, section Politaria) were assessed. The study investigated the spatial genetic structure among four putative species of spotted gum (broad-scale), as well as within a single population (fine-scale)of one species, using both molecular and quantitative markers. The spotted gum complex occurs naturally across a range of 2500 km in eastern Australia. Spatial genetic variation within and between
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46

SUSCA, Roberta Rosa. "Patterns of genetic and linguistic variation. A study of uniparental markers." Doctoral thesis, Università degli studi di Ferrara, 2017. http://hdl.handle.net/11392/2488149.

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This dissertation is divided in three sections and focuses on two of the projects I worked on during my three-years PhD, funded by a European Research Council (ERC) grant LanGeLin. Both the projects share the uniparental markers as tool used for the investigation of the human evolutionary history, but each of them addresses different scientific questions by means of a different combination of molecular and statistical methods. Part I is a technical summary on current knowledge about uniparental markers features and on the pros and cons of their usage for addressing questions stemming from th
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Lundmark, Per Erik. "Genetic and Genomic Analysis of DNA Sequence Variation." Doctoral thesis, Uppsala universitet, Molekylär medicin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-158486.

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The studies in this thesis describe the application of genotyping and allele specific expression analysis to genetic studies. The role of the gene NPC1 in Triglyceride metabolism was explored in mouse models and in humans on the population level in study I. NPC1 was found to affect hepatic triglyceride metabolism, and to be relevant for controlling serum triglyceride levels in mice and potentially in humans. In study II the utility of the HapMap CEU samples was investigated for tagSNP selection in six European populations. The HapMap CEU was found to be representative for tagSNP selection in a
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48

Miller, S. Shea. "Oat beta-glucan: Biochemistry, structure and genetic variation." Thesis, University of Ottawa (Canada), 1992. http://hdl.handle.net/10393/7507.

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An enzymatic assay designed for measurement of $\beta$-glucan in barley was modified to allow measurement of total $\beta$-glucan content in oats by manipulating the grinding and incubation protocol. Using the modified enzymatic assay, the range of genetic and environmental variation of $\beta$-glucan content in Canadian domestic and breeder's lines of oats was assessed using several cultivars grown in 5 locations in eastern Canada in 3 growing seasons. Analysis of variance indicated that the predominant source of variation was genetic. A second assay using Flow Injection Analysis (FIA) to mea
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49

Crompton, Tom. "Mobile DNA and genetic variation in Drosophila melanogaster." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/30330.

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Whilst it is commonly accepted that transposable elements can generate genetic variation, the significance of this for the maintenance and dissemination of such elements is controversial. Here long-term laboratory populations of Drosophila melanogaster, maintained at two discrete temperatures, are screened by Southern blotting for the patterns of insertion of several transposable elements (copia, mdg-2, mdg-4 and P). Consistent with a temperature-specific adaptive role for some insertions, several are apparently found at higher frequency in lines at one temperature. Further characterisation of
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50

Derero, Abayneh. "Genetic variation in Cordia africana Lam. in Ethiopia." Göttingen Cuvillier, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016247698&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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