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Artykuły w czasopismach na temat „German Hospital of the City of Philadelphia”

Autor: Grafiati

Data publikacji: 27 lipca 2024

Data aktualizacji: 31 lipca 2025

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1

Schweikardt, Christoph. "The Introduction of Deaconess Nurses at the German Hospital of the City of Philadelphia in the 1880s." Nursing History Review 18, no. 1 (2010): 29–50. http://dx.doi.org/10.1891/1062-8061.18.29.

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In 1884, seven deaconesses from Iserlohn, Germany, came to the Philadelphia German Hospital to take over nursing care and hospital administration. This article deals with the preparation and implementation of deaconess rule at the German Hospital and conflicts during the tenure of the first two Sisters Superior, Marie Krueger (1826–1887) and Wanda von Oertzen (1845–1897). Recruitment of the deaconesses took place within a network of relations between German and American motherhouses. Before their arrival in Philadelphia, the benefactor of the German Hospital, John D. Lankenau (1817–1901), had

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RANDHAWA, EKAMJEET, and MICHAEL STEPHEN. "EPIDEMIOLOGY OF NONTUBERCULOUS MYCOBACTERIUM FROM AN INNER-CITY PHILADELPHIA HOSPITAL IN PATIENTS WITH HIV." Chest 154, no. 4 (2018): 139A. http://dx.doi.org/10.1016/j.chest.2018.08.120.

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RANDHAWA, EKAMJEET, JANPREET MOKHA, and MICHAEL STEPHEN. "EPIDEMIOLOGY OF NONTUBERCULOUS MYCOBACTERIUM FROM AN INNER-CITY PHILADELPHIA HOSPITAL IN PATIENTS WITHOUT HIV." Chest 154, no. 4 (2018): 140A. http://dx.doi.org/10.1016/j.chest.2018.08.121.

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Ditmar, Mark F. "Requiem for a Hospital." Pediatrics 88, no. 2 (1991): 286–89. http://dx.doi.org/10.1542/peds.88.2.286.

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The splendor falls on castle walls And snowy summits old in story: The long light shakes across the lakes, And the wild cataract leaps in glory. Blow, bugle, blow, set the wild echoes flying, Blow, bugle; answer, echoes, dying, dying, dying. —from The Splendor Falls by Alfred, Lord Tennyson This is the story of the closure of a hospital and with it a part of American pediatric history. Children's Seashore House of Atlantic City is the nation's fourth oldest pediatric hospital. After 118 years, it will close in the summer of 1990 and move to a new facility in Philadelphia. The simple brick, lay

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Delov, E. "The results of the examination of German and some French institutions for the mentally ill." Neurology Bulletin VIII, no. 2 (2020): 1–75. http://dx.doi.org/10.17816/nb52841.

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The hospital for the mentally ill in Ene, which is also the clinic of Ene University, does not represent anything special. It is located in the most elevated part of the city according to Ober philosopher Weg, from where an excellent walk opens both to the city itself and to the surrounding, picturesquely spread mountains.

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Cunningham, Shayna D., Valerie Riis, Laura Line, et al. "Safe Start Community Health Worker Program: A Multisector Partnership to Improve Perinatal Outcomes Among Low-Income Pregnant Women With Chronic Health Conditions." American Journal of Public Health 110, no. 6 (2020): 836–39. http://dx.doi.org/10.2105/ajph.2020.305630.

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Safe Start is a community health worker program representing a partnership between a high-volume, inner-city, hospital-based prenatal clinic; a community-based organization; a large Medicaid insurer; and a community behavioral health organization to improve perinatal outcomes among publicly insured pregnant women with chronic health conditions in Philadelphia, Pennsylvania. As of June 2019, 291 women participated in the program. Relative to a comparison group (n = 300), Safe Start participants demonstrate improved engagement in care, reduced antenatal inpatient admissions, and shorter neonatal

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Burke, Andrew. "From Weimar to Winnipeg: German Expressionism and Guy Maddin." Acta Universitatis Sapientiae, Film and Media Studies 16, no. 1 (2019): 59–79. http://dx.doi.org/10.2478/ausfm-2019-0004.

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Abstract The films of Guy Maddin, from his debut feature Tales from the Gimli Hospital (1988) to his most recent one, The Forbidden Room (2015), draw extensively on the visual vocabulary and narrative conventions of 1920s and 1930s German cinema. These cinematic revisitations, however, are no mere exercise in sentimental cinephilia or empty pastiche. What distinguishes Maddin’s compulsive returns to the era of German Expressionism is the desire to both archive and awaken the past. Careful (1992), Maddin’s mountain film, reanimates an anachronistic genre in order to craft an elegant allegory ab

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Chu, Carolyn. "Seize the Hospital to Serve the People: A video interview with activist Cleo Silvers." Social Medicine 4, no. 1 (2008): 80. https://doi.org/10.71164/socialmedicine.v4i1.2009.244.

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Cleo Silvers is an activist and community/labor organizer who has been working in New York City since the 1960s. In this interview, she illustrates her background growing up in Philadelphia and how it led to experiences as a young VISTA volunteer in New York. Although her initial advocacy efforts and organizing began in the South Bronx school systems, Cleo relates how she quickly became fascinated with emerging public health issues in the Bronx and specifically with the poor care given to disadvantaged community members by local hospitals. As a community mental health worker and member of the

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Wnent, Jan, Stephan Seewald, Matthias Heringlake, et al. "Choice of hospital after out-of-hospital cardiac arrest - a decision with far-reaching consequences: a study in a large German city." Critical Care 16, no. 5 (2012): R164. http://dx.doi.org/10.1186/cc11516.

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Hackenberg, Roslind Karolina, Paul Stoll, Kristian Welle, et al. "Cervical spine injuries requiring surgery in a Level I trauma centre in a major German city." Acta Neurochirurgica 164, no. 1 (2021): 35–41. http://dx.doi.org/10.1007/s00701-021-05029-1.

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Abstract Background Cervical spine injuries (CSI) are rare in trauma patients, at about 9.2–16.5/100,000 inhabitants in Scandinavia and Canada, and the annual incidence of CSI surgeries in Norway is around 3.0/100,000 inhabitants. However, despite their rarity, the incidence of CSI has increased, thereby assuming an increasing need for surgery. Outside of Scandinavia, no data about the incidence of CSI and subsequent surgeries exist. Therefore, this study aimed to analyse CSI epidemiology and surgery in a German city with a Level I trauma centre both to understand the injury and improve needs–

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Milanovic, Jasmina, Sanja Milenkovic, Momcilo Pavlovic, and Dragos Stojanovic. "The founding of Zemun Hospital." Srpski arhiv za celokupno lekarstvo 142, no. 7-8 (2014): 505–10. http://dx.doi.org/10.2298/sarh1408505m.

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This year Zemun Hospital - Clinical Hospital Center Zemun celebrates 230th anniversary of continuous work, thus becoming the oldest medical facility in Serbia. The exact date of the hospital founding has been often questioned in history. Various dates appeared in the literature, but the most frequent one was 25th of February 1784. Until now, the document which confirms this has never been published. This article represents the first official publication of the document which confirms that Zemun Hospital was indeed founded on this date. The first hospitals started emerging in Zemun when the tow

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Burke, Michael, Jennifer Willert, Sunil J. Desai, and Richard Kadota. "Pediatric Treatment Guidelines for Philadelphia Positive (Ph+) Chronic Myelogenous Leukemia (CML): What Are They in Today’s Imatinib Era?" Blood 112, no. 11 (2008): 4399. http://dx.doi.org/10.1182/blood.v112.11.4399.4399.

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Abstract Background: The treatment of pediatric Philadelphia positive (Ph+) chronic myelogenous leukemia (CML) in the era of the tyrosine kinase inhibitors (TKI) continues to evolve with the role of allogeneic hematopoietic cell transplantation (allo-HCT) in these patients becoming more controversial. Imatinib has completely replaced allo-HCT for adult CML patients presenting in first chronic phase, reserving HCT for TKI resistant and/or advanced stage patients (accelerated phase and blast crisis). Whether treatment strategies in 2008 have changed for CML in pediatrics, from heavily allo-HCT b

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13

Jeck, Julia, Florian Jakobs, Anna Kron, Oliver A. Cornely, and Florian Kron. "Retrospective modelling of hospital bed capacities associated with the administration of remdesivir during the first wave of COVID-19 in a German metropolitan city." Journal of Antimicrobial Chemotherapy 77, no. 3 (2021): 753–57. http://dx.doi.org/10.1093/jac/dkab432.

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Abstract Objectives Internationally, healthcare systems are confronted by an ever-increasing scarcity of medical resources due to the ongoing novel coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to investigate the impact of remdesivir on the demand of hospital bed capacities for hospitalized COVID-19 patients and to evaluate the potentially created capacities for treating additional COVID-19 patients or elective treatments at the hospital. Methods An epidemiological model was developed that utilized the population of Cologne (Germany) during the first COVID-19 wave (fi

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Burke, Michael, Jennifer Willert, Sunil J. Desai, and Richard Kadota. "Pediatric Treatment Guidelines for Philadelphia Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): What Are They in today’s Imatinib Era?" Blood 112, no. 11 (2008): 4393. http://dx.doi.org/10.1182/blood.v112.11.4393.4393.

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Abstract Background: The treatment of pediatric Philadelphia positive (Ph+) leukemias in the era of the tyrosine kinase inhibitors (TKI) continues to evolve with the role of allogeneic hematopoietic cell transplantation (allo-HCT) in these high-risk patients becoming more controversial. Ph+ acute lymphoblastic leukemia (ALL) prior to imatinib in both pediatric and adult patients has often involved intensive chemotherapy, including consolidative allo-HCT. Whether treatment strategies in 2008 have changed for these Ph+ leukemias in pediatrics, from heavily allo-HCT based to TKI based medical the

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15

Frank, M. D., L. Andrä, W. Haacke, and M. Ragaller. "Out of hospital cardiac arrest (OHCA)—What is the first rhythm: A 3-year analysis of a German city." Resuscitation 81, no. 2 (2010): S74. http://dx.doi.org/10.1016/j.resuscitation.2010.09.306.

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Sadeq Abdo Mohammed Al- Wesabi, Radman Ahmad Ahmad Al- Nahar, Sadeq Abdo Mohammed Al Wesabi, Radman Ahmad Ahmad Al Nahar. "Nurses' knowledge towards Intravenous cannula insertion at public and private hospitals in Sana'a City- Yemen: معرفة الممرضات بإدخال الكانيولا الوريدية في المستشفيات العامة والخاصة في مدينة صنعاء – اليمن". Journal of medical and pharmaceutical sciences 5, № 2 (2021): 65–57. http://dx.doi.org/10.26389/ajsrp.s110321.

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Background: the Peripheral IV cannula is one of the most frequently used medical devices in the world; to give intravenous therapy with drugs, and blood components is indispensable in today’s health care.Objective: is to assessing nurses' knowledge towards IV cannula insertion.Methods: Descriptive, hospital- based study, was conducted in Sana'a city in university of science and technology hospital, republican educational hospital, Kuwait educational hospital and Saudi German hospital from June2018 to September 2018, study covered all nurse's in hospital they were (100) nurses, the data were pr

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Chechulina, Anna, Jasmin Carus, Philipp Breitfeld, et al. "Semi-Automated Mapping of German Study Data Concepts to an English Common Data Model." Applied Sciences 13, no. 14 (2023): 8159. http://dx.doi.org/10.3390/app13148159.

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The standardization of data from medical studies and hospital information systems to a common data model such as the Observational Medical Outcomes Partnership (OMOP) model can help make large datasets available for analysis using artificial intelligence approaches. Commonly, automatic mapping without intervention from domain experts delivers poor results. Further challenges arise from the need for translation of non-English medical data. Here, we report the establishment of a mapping approach which automatically translates German data variable names into English and suggests OMOP concepts. Th

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Rupa, Rosita, Tim Vladimirov, Mirza Pojskic, Christopher Nimsky, and Benjamin Voellger. "Dynamics in the Neurotrauma Catchment Area of a German University Hospital during the COVID-19 Pandemic." Healthcare 10, no. 8 (2022): 1376. http://dx.doi.org/10.3390/healthcare10081376.

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Objective: At the beginning of 2020, the COVID-19 pandemic enforced a rapid reallocation of healthcare resources. Our neurosurgical department is located in the German county of Marburg–Biedenkopf, about 80 km from the nearest major city. We were able to maintain our previously established open-door policy after the emergence of COVID-19. Here, we report on dynamics in the catchment area for neurotrauma patients at our department during the pandemic. Methods: 763 consecutive neurotrauma cases admitted to our department between 1 January 2018 and 31 December 2021 were analyzed retrospectively.

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Kleinschmidt, M., T. Floeth, and M. Greuél. "The German “netzwerk psychische gesundheit”: Establishing home treatment for patients with severe chronic mental disorders from a systemic approach." European Psychiatry 26, S2 (2011): 547. http://dx.doi.org/10.1016/s0924-9338(11)72254-4.

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IntroductionHome treatment models in treating severe chronic mental disorders including crisis intervention show more and more evidence to offer an excellent alternative to hospital treatment. In Germany, having higher hospitalization rates than almost any other country in Europe, it is even more necessary to evaluate such alternative option to hospital treatment.Objective/aim of studyAfter establishing a home treatment model based on Swedish, Finnish and Italian experiences in cooperation with a big German health insurance in Berlin, we present data evaluation after the first year of implemen

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Mohammed, Dnya Jaza, Sana Dlawar Jalal, Ahmed Khudair Yassin, and Ali Ibrahim Mohammed. "Pattern, clinical and laboratory features from of adult acute lymphoblastic leukemia patients from Kurdistan-Iraq." Advanced Medical Journal 5, no. 2 (2019): 55–59. http://dx.doi.org/10.56056/amj.2019.101.

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Background and objectives: Acute lymphoblastic leukemia is a heterogeneous group of neoplasm resulting from clonal proliferation and tissue infiltration by leukemic lymphoblasts. Adult acute lymphoblastic leukemia is character- ized by distinctive clinical and genetic features in comparison to childhood leukemia. This study aimed to outline the clinco-hematological features of adult Iraqi patients newly diagnosed with acute lymphoblastic leukemia in Kurdis- tan-Iraq. Methods:This study was conducted at Hiwa Cancer Hospital in Sulaimani City and Nanakali Hospital in Erbil City, Kurdistan, Iraq.

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Kravtsov, Sergey R. "Synagogue Architecture of Latvia between Archeology and Eschatology." Arts 8, no. 3 (2019): 99. http://dx.doi.org/10.3390/arts8030099.

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Synagogue architecture during the second half of the nineteenth century and the early part of the twentieth century was seeking novel modes of expression, and therefore the remains of ancient synagogues that were being discovered by western archeologists within the borders of the Biblical Land of Israel became a new source of inspiration. As far away as the New World, the design of contemporary synagogues was influenced by discoveries such as by the American Jewish architect, Arnold W. Brunner, who referenced the Baram Synagogue in the Galilee in his Henry S. Frank Memorial Synagogue at the Je

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Sljapic, Ziva, and Miljana Sljapic-Roganovic. "Child care in Vrsac and its development." Medical review 55, no. 9-10 (2002): 431–35. http://dx.doi.org/10.2298/mpns0210431s.

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Documents concerning history of medicine during the Turkish reign (1552-1716) are very rare. However, there is evidence of plague epidemic in 18th century and cholera epidemic in the 19th century. The first medical institutions: The German Communal Hospital, The Serbian Hospital and the Pharmacy were founded in the second half of the 18th century. In the year 1803, children were vaccinated against variola. The first Serbian book about child care ? "Cadoljub" was written by Dr. Gavrilo Pekarovic (1812-1851) during his studies of medicine in Budapest. In 1927 the city founded a dispensary for th

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Avner, Jeffrey R., and M. Douglas Baker. "Dog Bites in Urban Children." Pediatrics 88, no. 1 (1991): 55–57. http://dx.doi.org/10.1542/peds.88.1.55.

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As a result of a perceived increase in pit bull injuries, all children who presented to The Children's Hospital of Philadelphia during 1989 for evaluation of dog bite injuries were prospectively studied. Epidemiologic information was collected from parents, either at the time of visit or by phone on the following day. A total of 168 children were enrolled; the mean age was 8 years. Males outnumbered females 1.5:1. Most (61%) injuries occurred in or around the home and involved dogs known to the patient (77%). Types of injuries included abrasions (33%), punctures (29%), and lacerations (38%). T

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Sher, Stella A., Svetlana V. Nagornaya, and Olga R. Parenkova. "Providing Health Care for the Children in Smolensk During the Great Patriotic War (to the 80th Anniversary of Victory in the Great Patriotic War)." Current Pediatrics 24, no. 2 (2025): 69–75. https://doi.org/10.15690/vsp.v24i2.2891.

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This article presents the results of historical and medical study reflecting the state of children health care in Smolensk during the Great Patriotic War of 1941–1945. The article provides scientifically based evaluation of the situation in Smolensk regarding health condition of children remained on the territories occupied by fascist invaders during the Great Patriotic War, and the organization of children’s health care after the liberation of the occupied regions. We have studied government decrees, medical reports, administrative notes, and other documents from the State Archives of Russian

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Griewing, Sebastian, Michael Lingenfelder, Uwe Wagner, and Niklas Gremke. "Use Case Evaluation and Digital Workflow of Breast Cancer Care by Artificial Intelligence and Blockchain Technology Application." Healthcare 10, no. 10 (2022): 2100. http://dx.doi.org/10.3390/healthcare10102100.

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This study aims at evaluating the use case potential of breast cancer care for artificial intelligence and blockchain technology application based on the patient data analysis at Marburg University Hospital and, thereupon, developing a digital workflow for breast cancer care. It is based on a retrospective descriptive data analysis of all in-patient breast and ovarian cancer patients admitted at the Department of Gynecology of Marburg University Hospital within the five-year observation period of 2017 to 2021. According to the German breast cancer guideline, the care workflow was visualized an

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Maylath, E., J. Seidel, B. Werner, and P. Schlattmann. "Geographical analysis of the risk of psychiatric hospitalization in Hamburg from 1988 – 1994." European Psychiatry 14, no. 8 (1999): 414–25. http://dx.doi.org/10.1016/s0924-9338(99)00226-6.

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SummaryThe analysis of the geographical distribution of hospital cases is obviously important for the purpose of planning hospital services, but it is of even greater significance in the planning of psychiatric services. This concern motivated our seven-year-long study, which examined hospitalization risks among various categories of psychiatric disorders in the major German city of Hamburg. Our database encompassed 77% (n = 64,000) of all psychiatric admissions in a total of 41 hospitals, most of which are general hospitals. In order to carry out the geographical analysis we employed a new st

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Vergatti, Radu Ștefan. "DIMITRIE CANTEMIR ŞI CHIRURGIA." Arhivele Olteniei 37 (December 21, 2023): 81–94. http://dx.doi.org/10.59277/ao.37.06.

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One of the most important works left by Dimitrie Cantemir, among his rich writings, was "INCREMENTORVM ET DECREMENTORVM AVLAE OTHOMANICAE SIVE ALIOTHMANICAE HISTORIAE A PRIMA GENTIS ORIGINE AD NOSTRA VSQVE TEMPORA DEDVCTATE LIBRI TRES", translated nowadays under the title "HISTORY OF THE INCREASE AND THE DECAY OF THE OTTHMAN OR ALIOTHMAN COURT (FROM THE BEGINNINGS OF THE NATION TO OUR TIME), IN THREE BOOKS". Among other information, it also contains a description of the land and the city of Avlonia - i.e. Vlora (dominated then by the Sublime Porta), as well as the Albanians from that region wh

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Babić, Strahinja, Aleksandra Marjanović, Gordana Stanković-Babić, Nevena Babić, and Rade Babić. "Primarijus Dr. Milun Mitrović (1901-1978): The first children's surgeon in Niš." Medicinska rec 3, no. 3 (2022): 26–28. http://dx.doi.org/10.5937/medrec2201026b.

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Primarius Dr. Milun Mitrović (1901, Trnanje, Serbia - 1978, Niš, SFR Yugoslavia) was the first pediatric surgeon in Niš, and the fifth in Yugoslavia. He graduated from the Medical Faculty in Graz in 1928. He received the title of primarius in 1959. He won the award of the Liberation of the City of Niš for merits in the work and development of health care for the population of Niš (1960). He spoke German fluently. He worked in the Department of Pediatric Surgery at the Orthopedic Department of the General State Hospital in Belgrade until January 1, 1945, when he moved to the Surgical Department

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Maksimovic, Jovan. "Development of midwifery services in Vojvodina." Medical review 56, no. 7-8 (2003): 385–88. http://dx.doi.org/10.2298/mpns0308385m.

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This paper deals with the beginnings and development of midwifery services as well as schooling modalities and professional education of midwives in Vojvodina after gaining freedom from Turkish rule. Obstetrical services in the Military Border Region of Vojvodina were much better organized than in the civil, so-called 'provincial' part. In the second half of the 18th century, law regulations were brought and only midwives with certificates of universities and training courses of special midwifery schools in bigger towns could practice midwifery. At that time most trained midwives in Vojvodina

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Patel, Dhaval, Marshall Isaac Rosenberg, John Charles Leighton, and Claudia M. Dourado. "Barriers to accessing cancer care from patients’ perspective: A single cancer center experience." Journal of Clinical Oncology 42, no. 16_suppl (2024): e13520-e13520. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e13520.

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e13520 Background: Jefferson Einstein Hospital is a safety-net hospital that serves a diverse and primarily disadvantaged community in North Philadelphia. The population in this city has 21.5% of individuals living in poverty, which is almost double the rate in Pennsylvania. According to the National Cancer Institute’s Center to Reduce Cancer Health Disparities (NCI-CRCHD), people from low socioeconomic backgrounds and specific demographics often bear a more significant disease burden than the general U.S. population. Certain population groups experience cancer disparities due to their likelih

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Frank, Mark, Jörg Braun, Laura Haelke, and Katja Petrowski. "Traumatic Cardiac Arrest in Polytrauma–There are Survivors: A 10-Year Analysis from a German Helicopter Base." Prehospital and Disaster Medicine 38, S1 (2023): s45. http://dx.doi.org/10.1017/s1049023x23001541.

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Introduction:In Germany, emergency care is provided by ambulances and rescue helicopters. Emergency physicians are part of prehospital care. The rescue helicopter in Dresden covers the city with 540.000 inhabitants and surrounding areas. The goal of the study was to evaluate cases of traumatic cardiac arrest (TCA) and to describe factors that affect the primary success of prehospital cardiopulmonary resuscitation (CPR) in trauma.Method:Data of all emergencies from the German Air Rescue (DRF-Luftrettung®) Helicopter Base Dresden were recorded on a standardized protocol and transferred to a cent

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Ramos Peñafiel, Christian Omar, Adán Germán Gallardo-Rodríguez, Daniela Pérez Sámano, et al. "Comparison of Two Therapeutic Approaches (Pediatric vs. Adult) for Treating Acute Lymphoblastic Leukemia. Experience of Two Centers in Mexico City." Blood 142, Supplement 1 (2023): 5894. http://dx.doi.org/10.1182/blood-2023-185217.

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Background: Chemotherapy is the most frequently used strategy in treating adult acute lymphoblastic leukemia (ALL) in conjunction with monoclonal antibodies and tyrosine kinase inhibitors. One of the primary considerations is the type of treatment based on pediatric inspiration regimens (CALGB10403, BFM, St Jude XIII) or regimens for adult patients (HyperCVAD), with pediatric regimens being those that have improved the prognosis in the young adult population. Along with this scheme, strict monitoring through measurable residual disease (MRD) is the main dynamic prognostic factor since its posi

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Rimmele, Martina, Jenny Wirth, Sabine Britting, et al. "Improvement of transitional care from hospital to home for older patients, the TIGER study: protocol of a randomised controlled trial." BMJ Open 11, no. 2 (2021): e037999. http://dx.doi.org/10.1136/bmjopen-2020-037999.

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IntroductionIn Germany, an efficient and feasible transition from hospital to home for older patients, ensuring continuous care across healthcare settings, has not yet been applied and evaluated. Based on the transitional care model (TCM), this study aims to reduce preventable readmissions of patients ≥75 years of age with a transitional care intervention performed by geriatric-experienced care professionals. The study investigates whether the intervention ensures continuous care during transition and stabilises the care situation of patients at home.Methods and analysesRandomised controlled c

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Nguyen, Hoang-Quy, Hong-Duc Phan-Thi, and Thi-Hong-Van Le. "Abstract PO5-05-07: Efficacy and safety of first line CDK4/6i plus endocrine therapy for patients with HR+/HER2- metastatic breast cancer:initial real-world experience at Ho Chi Minh city oncology hospital, Viet Nam." Cancer Research 84, no. 9_Supplement (2024): PO5–05–07—PO5–05–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-05-07.

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Abstract Background The cyclin-dependent kinases (CDK)4/6 inhibitors (CDK4/6i) palbociclib and ribociclib have been available in Viet Nam since 2021 for the treatment of hormone receptor-positive metastatic breast cancer (MBC). Data regarding CDK4/6i benefit in Vietnamese MBC are sparse. This study evaluated the impact of CDK4/6i in first-line HR+/HER2− MBC using real-world experience at Ho Chi Minh City Oncology Hospital. Methods A single-institution study analyzed retrospective data from 108 patients treated with palbiciclib or ribociclib with endocrine therapy in first-line in HR+/HER2– MBC

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Cimpeanu, Emanuela, Eve Frangopoulos, Ana M. Ventura, Edwin Chiu, Bo Lin, and Evelyn Taiwo. "Abstract P4-03-05: HER2 + Breast Cancer in Afro-Caribbean Women in New York City." Cancer Research 83, no. 5_Supplement (2023): P4–03–05—P4–03–05. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-03-05.

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Abstract Background: Human Epidermal Growth Factor receptor 2 (HER2) protein overexpression and/or amplification positive breast cancer accounts for 14% of breast cancer cases in the United States. The use of anti-HER2 targeted therapy in combination with chemotherapy has resulted in better response rates leading to better outcomes in patients with this breast cancer subtype. Few studies directly investigate breast cancer outcomes in Afro-Caribbean women in the U.S, and fewer studies have investigated HER2 positive (HER2+) disease in this patient group. We describe the clinicopathologic charac

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Schäffler, Henning, Dominik Dannehl, Kristina Veselinovic, et al. "Abstract PO5-16-11: Novel antibody-drug-conjugates in clinical routine: adherence, efficacy and tolerability - real-world data from German breast centers." Cancer Research 84, no. 9_Supplement (2024): PO5–16–11—PO5–16–11. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-16-11.

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Abstract The third-generation antibody-drug conjugates, Trastuzumab-Deruxtecan (T-DXd) and Sacituzumab Govitecan (SG), have been approved for the treatment of metastatic breast carcinoma in various subtypes and therapeutic settings based on compelling Phase III study data. (DESTINY-Breast03 (T-DXd; HER2-positive), DESTINY-Breast04 (T-DXd; HER2-low), ASCENT (SG; triple-negative), and TROPiCS-02 (SG; HR+/HER2-negative). The aim of this retrospective study conducted at two major German Breast centers was to evaluate the tolerability, adherence, and efficacy of both substances in the real-world se

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Alvarado-Muñoz, Juan, Agatha Reyes-Morales, Marco Chivalan, et al. "Abstract P5-03-17: BRCA1/2 gene mutations in patients with high-risk breast cancer in a tertiary-level hospital in Guatemala." Cancer Research 83, no. 5_Supplement (2023): P5–03–17—P5–03–17. http://dx.doi.org/10.1158/1538-7445.sabcs22-p5-03-17.

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Abstract Objectives, to stablish the frequency of BRCA1/2 mutation rate in high-penetrance breast cancer susceptibility population Methods Based on NCCN guidelines for testing criteria for high-penetrance breast cancer susceptibility genes genetic counseling was offered to 140 breast cancer patients in the hemato-oncology unit of Roosevelt Hospital at Guatemala City performing test with NGS and MLPA technology from 2019 to 2021. Results The overall BRCA1/2 mutation rate high-risk patients were 23% (33/140). Of the patients with mutations, 66.6% (22/33) had BRCA1 mutation, 33.3% (11/33) had BRC

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Xie, Chencheng, Jonathan M. Fenkel, Dina L. Halegoua-DeMarzio, et al. "Acute Liver Failure Requiring Liver Transplantation due to Acute Hepatitis A Virus Infection." Case Reports in Transplantation 2021 (December 27, 2021): 1–4. http://dx.doi.org/10.1155/2021/5159934.

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Introduction. Hepatitis A infection (HAV) is generally characterized by an acute icteric illness or may have a subclinical self-limited course, although rarely, can result in fulminant hepatitis and death. In 2019, the City of Philadelphia declared a public health emergency due to an HAV outbreak. We are reporting a series of four cases of acute liver failure (ALF) requiring liver transplantation (LT) due to acute HAV. Methods. Chart review and case descriptions of four patients with acute HAV-related ALF who were expeditiously evaluated, listed as Status 1A, and who underwent LT between Augus

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De Vasconcelos, Ana Cecilia, Candice Santos, Jurema Telles, Maria Julia Mello, and Bárbara Luz. "Abstract PO3-18-02: RISK FACTORS FOR DEATH IN ELDERLY PATIENTS WITH BREAST CANCER TREATED IN AN ONCOLOGY REFERENCE HOSPITAL IN THE CITY OF RECIFE, BRAZIL." Cancer Research 84, no. 9_Supplement (2024): PO3–18–02—PO3–18–02. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-18-02.

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Abstract Background: Breast cancer (BC) is the most common type of cancer among women in the world and in Brazil as well. Age is the most important risk factor for the development of cancer. The treatment of BC in elderly women is particularly challenging, as physiological changes, functional deficits, comorbidities and the use of polypharmacy can alter the risk of toxicity. We conducted this trial to determine the risk factors for deaths in less than 180 days after admission in elderly cancer patients with BC treated at the Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife

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Balabanovich, T. I., K. M. Surmach, S. N. Dziamidzik, V. V. Budrevich, and R. S. Warnakulasuriya Fernando. "Gottron’s Carcinoid Papillomatosis: Case Report." Kuban Scientific Medical Bulletin 30, no. 6 (2023): 81–88. http://dx.doi.org/10.25207/1608-6228-2023-30-6-81-88.

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Introduction. Gottron’s papillomatosis is a rare benign type of dermatosis with pseudoepitheliomatous hyperplasia of the epidermis, first described as an independent disease by the German dermatologist H.A. Gottron. Invasive epidermal growth and hyperkeratosis reveal no signs of malignancy. Chronic venous insufficiency and lymphedema can be associated with various secondary skin lesions: the formation of ulcers, hyperkeratosis and skin papillomatosis, as well as infectious complications. Skin papillomatosis may be a manifestation of paraneoplastic syndrome, which requires a careful differentia

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Zetts, Rachel M., Andrea Stoesz, Andrea M. Garcia, et al. "Primary care physicians’ attitudes and perceptions towards antibiotic resistance and outpatient antibiotic stewardship in the USA: a qualitative study." BMJ Open 10, no. 7 (2020): e034983. http://dx.doi.org/10.1136/bmjopen-2019-034983.

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ObjectivesAt least 30% of outpatient antibiotic prescriptions are unnecessary. Outpatient antibiotic stewardship is needed to improve prescribing and address the threat of antibiotic resistance. A better understanding of primary care physicians (PCPs) attitudes towards antibiotic prescribing and outpatient antibiotic stewardship is needed to identify barriers to stewardship implementation and help tailor stewardship strategies. The aim of this study was to assess PCPs current attitudes towards antibiotic resistance, inappropriate antibiotic prescribing and the feasibility of outpatient steward

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Lagarde-Santillan, Laura Kay, Montserrath Alvarado-Hernández, Eucario León-Rodríguez, and Yanin Chavarri-Guerra. "Abstract P4-03-09: Breast Cancer Long Survivorship Program Experience in Mexico City." Clinical Cancer Research 31, no. 12_Supplement (2025): P4–03–09—P4–03–09. https://doi.org/10.1158/1557-3265.sabcs24-p4-03-09.

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Abstract Background: Breast cancer survivors may experience a significant burden of side effects from cancer therapies. Timely management of such effects, including strategies to promote health and wellness among breast cancer survivors, is an unmet need in low- and middle-income countries, where cancer care is centered on diagnosis and active treatments. Our aim is to describe clinical characteristics and outcomes of women with a personal history of breast cancer included in a long-term breast cancer survivorship program at a third level hospital in Mexico City. Methods: Women with a personal

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Parger, Anna-Maria, Daniela Muhr, Christian F. Singer, and Yen Y. Tan. "Abstract P4-12-10: Cancer worry among healthy BRCA mutation carriers in Austria: A pilot study." Cancer Research 82, no. 4_Supplement (2022): P4–12–10—P4–12–10. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-12-10.

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Abstract Background: Breast cancer risk in BRCA mutation carriers is up to 10 times higher compared to the general population. To support these patients, it is imperative to understand the worry that these patients face when they find out that they are a pathogenic mutation carrier. The aim of this study was to assess cancer worry among healthy BRCA mutation carriers using the 8-item cancer worry instrument. As there is no German version available, the aim of the study was two-fold. One was to translate the cancer worry scale (CWS) into German, and the second was to pilot the questionnaire to

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Guadarrama-Orozco, Jorge Alberto, Paula Leal-Anaya, and Eva Guerrero-Santillan. "Abstract 6133: Genetic profiling landscape among gynecological and breast cancer patients in the borde city of Tijuana, Mexico: A comprehensive study." Cancer Research 84, no. 6_Supplement (2024): 6133. http://dx.doi.org/10.1158/1538-7445.am2024-6133.

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Abstract Background: Individuals in Tijuana have been identified as having multicultural and racial diversity. In Baja, California, Mexico, the prevalence and composition of cancer-predisposing germline variants in gynecologic cancers in Tijuana patients have not been evaluated. Aim and Methods: We aimed to evaluate the prevalence of pathogenic variants (PV) using a panel of 84 cancer-predisposing genes in breast, endometrial, and ovarian cancer from the General Hospital of Tijuana during the period of October 2021-October 2023, who were contacted and invited to participate in the evaluation.

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Häfner, H., A. Riecher, K. Maurer, W. Löffler, P. Munk-Jørgensen, and E. Strömgren. "How does gender influence age at first hospitalization for schizophrenia? A transnational case register study." Psychological Medicine 19, no. 4 (1989): 903–18. http://dx.doi.org/10.1017/s0033291700005626.

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SYNOPSISNumerous studies have reported a lower mean age at first hospitalization for schizophrenia in males than in females. For this finding not only a gender difference in age at first onset of schizophrenia, but also other factors can be responsible. With the aim of providing a comprehensive analysis of gender differences in onset, symptomatology and course of schizophrenia, we started by testing the hypothesis postulating a gender difference in mean age at first hospitalization. By using the Danish and the Mannheim psychiatric case registers we analysed all hospital admissions for schizoph

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Silva, Marcia, Vanessa Monterio Sanvido, Vinicius Aquino Correa, et al. "Abstract P4-04-12: Covid 19 pandemic: effects on the diagnosis and treatment of breast cancer in two large teaching hospitals in the city of São Paulo - Brazil." Clinical Cancer Research 31, no. 12_Supplement (2025): P4–04–12—P4–04–12. https://doi.org/10.1158/1557-3265.sabcs24-p4-04-12.

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Abstract Objective: To evaluate the impact of the COVID 19 pandemic on the diagnosis and treatment of breast cancer in São Paulo - Brazil. Methods: Observational, analytical, cross-sectional, retrospective study, in which patients treated at the Mastology Outpatient Clinic of the Escola Paulista e Medicina - Universidade Federal de São Paulo (EPM-UNIFESP) and the Mastology Outpatient Clinic of Hospital Santa Marcelina Itaquera with diagnosis of breast carcinoma, from March to December 2019 and from March to December 2020. Results: In this study, information from 361 patients was considered. ti

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Soucy, Melissa, Nick Renzette, Xinming Zhuo, et al. "Abstract 2233: Clinical validation of a methylation array-based diagnostic assay for improved classification of CNS tumors." Cancer Research 83, no. 7_Supplement (2023): 2233. http://dx.doi.org/10.1158/1538-7445.am2023-2233.

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Abstract Current cIMPACT-NOW and WHO guidelines state that the accurate diagnosis of many central nervous system (CNS) tumors must not only incorporate traditional histological findings but also include additional molecular data derived from sequence and methylation profiling techniques. To address this clinical need, our group has adapted and clinically validated the CNS tumor classifier that was pioneered and developed by the German Cancer Research Network (DKFZ) and University Hospital Heidelberg for both adult and pediatric CNS tumors. The classifier analyzes whole genome methylation data

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Batista, Bruno, Sergio Ioshii, Sergio Padilha, Jacqueline Nabhen, Tayza Ostroski, and Caroline Batista. "Abstract PO3-15-07: False-negative results of hyperexpression of HER2 receptor in breast cancer at a public tertiary hospital in Brazil." Cancer Research 84, no. 9_Supplement (2024): PO3–15–07—PO3–15–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-15-07.

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Abstract Introduction: Breast cancer (BC) is the second leading cause of cancer death in women worldwide. One of the major advances in BC management was its molecular classification, especially regarding the Human Epidermal growth factor Receptor 2 (HER2). HER2 positive tumors are at greater risk of visceral metastasis and are associated with worse survival rates. Thus, the use of specific drugs to target this pathway is essential and false-negative have a high impact on patient care. HER2 status is usually accessed using immunohistochemistry (IHC), but false-negatives results occur. When IHC

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van Mark, Anke, Tim Hallstein, Fabian Holzgreve, David A. Groneberg, and Daniela Ohlendorf. "How do different navigation systems affect emergency response time? A prospective simulation study." BMJ Open 14, no. 7 (2024): e079094. http://dx.doi.org/10.1136/bmjopen-2023-079094.

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ObjectiveThere has not been a theoretical test run in Germany that compares different navigation systems with an industry solution (MapTrip112). The aim of this study was to compare navigation systems to elucidate whether the emergency response time (ERT) was reduced and, consequently, whether the adherence to the travel time improved.DesignProspective, simulation study, cross-sectional study.SettingOffices of the Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University Frankfurt (60 590 Frankfurt am Main, Germany). The situation-adaptable industry navi

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Otto, William, Rebekah Dumm, Yasaman Fatemi, and Sanjeev K. Swami. "664. Clinical Impact of Cell-Free DNA Metagenomics in Diagnosing Infectious Diseases in Pediatrics: A Single-Center Experience." Open Forum Infectious Diseases 8, Supplement_1 (2021): S434. http://dx.doi.org/10.1093/ofid/ofab466.861.

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Abstract Background Metagenomic next-generation sequencing (mNGS) of plasma cell-free DNA has significant potential to improve infectious diseases diagnostics through unbiased detection of pathogens. However, the optimal patient population or clinical condition for this testing has not been determined. Methods We performed a retrospective review of all orders for plasma cell-free DNA mNGS using the Karius test (Karius, Redwood City, CA) from The Children’s Hospital of Philadelphia from 7/1/19-4/30/21. Chart review then determined if the test had a positive, negative, or no clinical impact. Res

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