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Rozprawy doktorskie na temat „GLP-1 Agonists”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Ekenberg, Marie. "Swedish diabetes patients’ experiences of using GLP-1 receptor agonists (GLP-1 RAs) : A qualitative interview study." Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-434750.

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Background: The world prevalence of diabetes mellitus in 2019 was 8.3%, out of which 85-90% have type 2 diabetes mellitus (T2DM). Numerous drugs for treating T2DM are approved, and one of the newer classes of drugs are GLP-1 receptor agonists (GLP-1 RAs). In Sweden during 2015 to 2019, the number of patients using GLP-1 RAs has increased by 280%. Despite this, few studies have explored the experiences of patients using these drugs. Aim: The aim of this study was to gain knowledge about how patients diagnosed with T2DM experience and understand their treatment with GLP-1 RAs in Sweden. Method

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Babateen, Omar M. "GABA signaling regulation by GLP-1 receptor agonists and GABA-A receptors modulator." Doctoral thesis, Uppsala universitet, Fysiologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282431.

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GABA (γ-aminobutyric acid) is the main neuroinhibitory transmitter in mammalian brains. It binds to GABA-A and GABA-B receptors. The GABA-A receptors are ligand-gated chloride channels. A variety of GABA-A receptor agonists and antagonists have been developed to study the GABA-mediated inhibition and to explore new medications. In this thesis I have examined the role of GABA in brain tumors and the effects of the metabolic hormone GLP-1 on GABAergic signaling in neurons. I studied if GABA-A receptors subunits were expressed and formed functional ion channels in the glioblastoma cell line U304

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Hart, Nathaniel. "Combinatorial Targeting of the Glucagon-Like Peptide-1 And Sulfonylurea-1 Receptors Using a Complimentary Multivalent Glucagon-Like Peptide-1/Glibenclamide Ligand for the Improvement of β-Cell Targeting Agents and Diabetic Treatment". Diss., The University of Arizona, 2013. http://hdl.handle.net/10150/311363.

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A scourge of Type I and Type II diabetes impacts the health of hundreds of millions worldwide. The number and prevalence of diabetics are expected to rise dramatically in the next two decades. Diabetes is defined by chronic hyperglycemia which can result in a number of detrimental and costly metabolic, renal, cardiovascular and neurological disorders. Identification of at risk individuals and effective blood glucose management are critical to improving diabetic outcomes and preventing hyperglycemic complications. Diabetes prevention and treatment is limited by the understanding of islet functi

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Holmes, Sophie. "The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells." Thesis, Lancaster University, 2018. http://eprints.lancs.ac.uk/129821/.

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Arguably the causative agent of Alzheimer's disease (AD), amyloid beta (Aβ)- peptides, are generated by sequential proteolysis of the amyloid precursor protein (APP) by β- and γ-secretase activities. Alternatively, APP can be processed nonamyloidogenically by an α-secretase activity that cleaves within the Aβ-domain, precluding the formation of intact Aβ-peptides and liberating a neuroprotective fragment, sAPPα. This latter proteolytic event is catalysed by a disintegrin and metalloproteinase (ADAM) 10. Recent research has suggested that glucagon-like peptide-1 (GLP-1) analogues; Lixisenatide,

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Ferreira, Mari Cassol. "Análise da resposta hormonal pancreática antes e após tratamento com GLP-1 mimético em indivíduos com diabetes tipo 2 portadores da variante rs7903146 do gene TCF7L2." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-01112013-113904/.

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Introdução: O gene TCF7L2 (Transcription Factor 7-Like 2) codifica o fator de transcrição de mesmo nome que, tem importante papel na via Wnt de sinalização intra celular. A via Wnt é constituída por proteínas de integração e ligação dos processos de diferenciação e multiplicação celulares, interagindo com os fatores TCF, e ativando a expressão de genes relacionados ao TCF7L2, sendo este amplamente expresso em vários tecidos. Dados epidemiológicos atuais não deixam dúvidas quanto à forte associação de polimorfismos do gene TCF7L2 com o diabetes tipo 2 (DM2) em diferentes etnias. Apesar de serem

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6

Hoguet, Vanessa. "Optimisation de nouveaux agonistes topiques intestinaux du récepteur aux acides biliaires TGR5 pour le traitement du diabète de type 2." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S024/document.

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Le récepteur membranaire TGR5 (Takeda G Protein-coupled Receptor 5), est un récepteur ubiquitaire sensible aux acides biliaires. Il est exprimé dans de nombreux tissus et organes dont l’intestin (dans les cellules entéroendocrines L), la vésicule biliaire, les muscles lisses et squelettiques, le tissu adipeux brun et dans certaines cellules immunitaires. Des études menées in vitro et in vivo chez l’animal ont montré des effets bénéfiques de l’activation de TGR5 sur l’homéostasie énergétique et glucidique. Il est maintenant communément admis que les effets bénéfiques de TGR5 sur l'homéostasie d

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7

Lasalle, Manuel. "TGR5, cible thérapeutique pour le traitement du diabète de type 2 et ses complications métaboliques : de la chimie aux effets biologiques." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S023/document.

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Les acides biliaires sont depuis longtemps connus pour leur propriété d’agents solubilisant des graisses et des vitamines liposolubles, permettant ainsi une absorption efficace de ces nutriments lors de la digestion. Depuis les années 2000, plusieurs équipes ont montré que ces molécules étaient également dotées de propriétés de signalisation, en particulier via l’activation de deux récepteurs : le récepteur nucléaire FXR, et le récepteur membranaire TGR5. Le récepteur TGR5 est exprimé dans de très nombreux tissus, dont les muscles lisses et squelettiques, le tissu adipeux brun, la vésicule bil

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8

Harkavyi, Alexander. "Neuroprotective effect of GLP-1 receptor agonist Exendin-4 in rat models of Parkinson's disease." Thesis, University College London (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.515060.

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Yamane, Syunsuke. "GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated β-cell damage in Akita mice". Kyoto University, 2011. http://hdl.handle.net/2433/147341.

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10

Mounger, David Kyle, Kynlee Hillard, Brooke Tipton, Grayson D. White, and Matthew R. Zahner. "GLP-1 agonist liraglutide increases metabolic- and cardiovascular-related sympathetic activity of the central nervous system." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/asrf/2019/schedule/58.

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Metabolic syndrome is associated with pathologies that include type 2 diabetes, hypertension, and dyslipidemia, all of which increase the risks of heart disease. Glucagon-like peptide (GLP-1) is a hormone produced by intestinal enteroendocrine L‑cells. GLP-1 increases insulin sensitivity, augments glucose-dependent insulin secretion, and suppresses glucagon release. GLP-1 also works centrally to decrease appetite and increase metabolism. Evidence suggests that the beneficial effect is mediated by metabolically related sympathetic neurons within the hypothalamus. Although the hypothalamus conta

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11

Murakami, Takaaki. "Non-invasive evaluation of GPR119 agonist effects on β-cell mass in diabetic male mice using ¹¹¹In-exendin-4 SPECT/CT". Kyoto University, 2020. http://hdl.handle.net/2433/253194.

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12

Cegla, Jaimini. "Glucagon and GLP-1 receptor dual agonism : a therapeutic approach for the treatment of obesity." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/58235.

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Obesity is a growing global epidemic and current medical therapies have proven inadequate. Endogenous satiety hormones provide an attractive target for the development of drugs which aim to cause effective weight loss with minimal side effects. Two related peptide hormones, glucagon and glucagon-like peptide 1 (GLP-1), are the subject of this thesis. Both have been found to reduce appetite and cause weight loss. Additionally, glucagon increases energy expenditure. GLP-1 also improves glucose homeostasis, whereas glucagon causes undesirable hyperglycaemia. It is proposed that co-administration

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13

Sharaf, Sharaf Ezzat. "The effect of exercise in NAFLD and a GLP-1 receptor agonist in type 2 diabetes on lipid metabolism." Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/813082/.

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Background: Hypertriglyceridaemia increases the risk of developing an atherogenic lipoprotein phenotype (ALP) in patients with type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD). An ALP is associated with an increased the risk of coronary heart disease (CHD) and cardiovascular disease (CVD). Objectives: To determine the effects of exercise and a glucagon like peptide-1 (GLP-1) receptor agonists on hypertriglyceridaemia and high-density lipoprotein (HDL) metabolism in patients with altered lipid metabolism, by conducting two clinical trials using stable isotope trace labelling

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14

Massimino, Alberto. "Effetti degli agonisti del recettore del Glucagon Like Peptide - 1 (rGLP-1) sull equilibrio del sistema nervoso autonomico: studio comparativo in pazienti diabetici di tipo 2 trattati con terapia insulinica associata ad ipoglicemizzanti orali." Doctoral thesis, Università di Catania, 2012. http://hdl.handle.net/10761/1024.

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Il ruolo del GLP-1 a livello nervoso e cardiovascolare è documentato da diverse osservazioni : a) Il GLP-1 oltre che secreto dalle cellule L ileali è anche sintetizzato dai neuroni del nucleo del tratto solitario del SNC. b) Sono stati riscontrati recettori per il GLP-1 a livello cardiaco ed in alcune aree del SNC che modulano il controllo del sistema nervoso autonomico (35). c) Evidenze scientifiche supportano l ipotesi che specifiche vie nervose formate dalle efferenze dei sistemi parasimpatico e simpatico siano capaci di mediare l effetto periferico del GLP-1 sulla variabilità della frequen

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15

Mittag-Roussou, Vasiliki [Verfasser]. "GLP-1 Agonisten- und SGLT-2 Inhibitoren-Therapie bei Patienten mit nicht alkoholischer Fettlebererkrankung und Diabetes mellitus Typ 2 / Vasiliki Mittag-Roussou." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2020. http://d-nb.info/1231792124/34.

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Abd, El Aziz Mirna Safia [Verfasser], Juris [Gutachter] Meier, and Horst Harald [Gutachter] Klein. "Metaanalyse von direkten Vergleichsstudien zwischen GLP-1 Rezeptor-Agonisten und Insulin in der Therapie des Typ 2 Diabetes : Unterschied zwischen kurz- und lang-wirksamen Präparaten? / Mirna Safia Abd El Aziz ; Gutachter: Juris Meier, Horst Harald Klein ; Medizinische Fakultät." Bochum : Ruhr-Universität Bochum, 2019. http://d-nb.info/1180028171/34.

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Fetter, Katie L. "Efficacy of Bydureon in Adults with Type 2 Diabetes." UNF Digital Commons, 2014. http://digitalcommons.unf.edu/etd/490.

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Type 2 diabetes is still rapidly on the rise today, affecting 10.5% of individuals in the United States between the ages 45 to 64 and 18.4% of those between the ages of 65 to 74. In the past two decades, type 2 diabetes has doubled in all age groups. Many adults with type 2 diabetes experience difficulty managing their blood sugars, which can result in a range of further complications. One of the newest treatment options on the market today is a glucagon-like peptide-1 (GLP-1) receptor agonist, Bydureon. Similar to Byetta, Bydureon has a main ingredient of exenatide. It offers once a week dosi

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Santos, Mauro André Marques. "A incidência de neoplasias no tratamento com agonistas do GLP-1R." Master's thesis, 2017. http://hdl.handle.net/10316/83767.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>O presente documento inclui a monografia intitulada “A incidência de neoplasias no tratamento com agonistas do GLP-1R” e os relatórios dos estágios realizados em farmácia comunitária e INFARMED, I.P..Os agonistas dos recetores do GLP-1 (GLP-1RA), são uma das mais recentes terapêuticas com indicação para a Diabetes Mellitus (DM) tipo 2. Diferenciam-se dos demais por possuírem um efeito glucose dependente, impedindo a ocorrência de hipoglicémia.Os doentes com DM tipo 2 apresentam resistênc

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Barbosa, Joana Rafaela Sousa. "Simultaneous administration of insulin and GLP-1 agonists. Technologically possible?" Master's thesis, 2017. http://hdl.handle.net/10316/83770.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>A prática regular de exercício físico juntamente com uma alimentação equilibradasão, nos dias de hoje, fundamentais para a implementação de um estilo de vida saudável, sendo este indispensável quer para a prevenção como para o controlo de várias doenças.A diabetes mellitus, cuja prevalência tem aumentado drasticamente, também obedecea este conjunto de ditas medidas não farmacológicas, como primeiro passo de atuação. No entanto, esta abordagem na maior parte dos casos não é suficiente, se

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20

M, Trabucco. "Gli effetti del glucagone e degli agonisti del GLP-1R in un modello di precursori adiposi umani Effects of glucagon and GLP-1 receptors agonists on human adipose precursors." Doctoral thesis, 2022. http://hdl.handle.net/2158/1275960.

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Lo sviluppo di obesità si associa ad una disfunzione del tessuto adiposo bianco (WAT) e a disregolazione della funzione adipocitaria. Il tessuto adiposo bruno (BAT), a differenza di quello bianco, accumula un minor quantitativo di lipidi che trasforma in calore esercitando una funzione di regolazione positiva sull’equilibrio metabolico. Per questo motivo, se da una parte vi è un crescente interesse nella ricerca di nuove strategie terapeutiche basate su un’azione diretta sul tessuto adiposo bianco, allo stesso tempo risulta rilevante la possibilità di stimolare il tessuto adiposo bruno nell’ad

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Rodrigues, Isabel Maria Hipólito Reis Dias. "Effects of liraglutide and exenatide, two GLP-1 agonists, in vascular wall cells." Master's thesis, 2016. https://repositorio-aberto.up.pt/handle/10216/89125.

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Rodrigues, Isabel Maria Hipólito Reis Dias. "Effects of liraglutide and exenatide, two GLP-1 agonists, in vascular wall cells." Dissertação, 2016. https://repositorio-aberto.up.pt/handle/10216/89125.

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Santos, Andreia Filipa Rodrigues dos. "Lessons learned on the safety of GLP-1 receptor agonists from post-marketing experience." Master's thesis, 2016. http://hdl.handle.net/10451/28844.

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Tese de mestrado, Mestrado em Regulação e Avaliação do Medicamento e Produtos de Saúde, Universidade de Lisboa, Faculdade de Farmácia, 2017<br>Diabetes Mellitus (DM) is one of the most important diseases at public health level around the world. Over the last 25 years there has been a dramatic increase in the number of people with diabetes around the world. In Portugal, in 2014 the estimated prevalence of Diabetes in population with ages between 20 and 79 years was 13.1%, i.e. more than 1 million of Portuguese people in this age range had Diabetes. During the last decade, in Portugal, it has b

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Teixeira, Paula Cristina Cardoso. "Psoriasis patients with obesity and type 2 biabetes: the effect of glucagon-like peptide 1 (GLP-1) receptor agonists." Master's thesis, 2015. https://repositorio-aberto.up.pt/handle/10216/79077.

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Teixeira, Paula Cristina Cardoso. "Psoriasis patients with obesity and type 2 biabetes: the effect of glucagon-like peptide 1 (GLP-1) receptor agonists." Dissertação, 2015. https://repositorio-aberto.up.pt/handle/10216/79077.

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Tavares, Sara Mariana Oliveira Mendonça Matos. "Internship Report and Monograph "The Role of Pharmacist managing Type 2 Diabetic Patients Undergoing GLP-1 RAs Therapies"." Master's thesis, 2017. http://hdl.handle.net/10316/83644.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>Internship Report: The finishing of the five years of the master degree in pharmaceutical sciences requires an internship in community pharmacy . This makes all the sense , since it is in this particular area where pharmacists have a major role . The mentioned internship occured from January to June 2017 at Campos Pharmacy . In this report is made a SWOT analysis of the internship , in which strenghts , weaknesses , opportunities and threats are identifyed . Mono

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"Anti-emetic potential of a GLP-1 receptor antagonist in the ferret." 2013. http://library.cuhk.edu.hk/record=b5884357.

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Lu, Zengbing.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 206-217).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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"GLP-1 receptor agonist exendin-4 improves glycemic control through beta cell and non-beta cell mechanism." Thesis, 2011. http://library.cuhk.edu.hk/record=b6075398.

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Fan, Rongrong.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2011.<br>Includes bibliographical references (leaves 130-150).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.

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Nóbrega, Carlota Sofia Ferreira de. "Efeitos Vasculares do Agonista do Recetor Glucagon-like peptide 1 (Liraglutido) num Modelo Animal de Diabetes tipo 1." Master's thesis, 2017. http://hdl.handle.net/10316/83682.

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Dissertação de Mestrado em Farmacologia Aplicada apresentada à Faculdade de Farmácia<br>Glucagon-like peptide 1 (GLP-1) is a crucial hormone that binds to its receptor (GLP-1R) and plays several beneficial roles, being is main function potentiating insulin secretion inpancreatic β cells, induced by the entry of nutrients (''incretin effect''). Thus, GLP-1R agonists(GLP-1RAs) correspond to one of the main therapeutic targets for the treatment of DMT2,such as Liraglutide, since, in addition to insulin secretion, they also promote the increase ofproliferation and the decrease of the apoptotic rat

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Behbahani, Sara. "The role of GLP-1 receptor agonist as a potential treatment for non-alcoholic fatty liver disease and non-alcoholic steatohepatitis." Thesis, 2017. https://hdl.handle.net/2144/26621.

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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver dysfunction in the western world and one of the main contributors to cirrhosis and potentially liver cancer and liver failure. A variety of behaviors and other factors can predispose certain individuals to an increased risk of developing NAFLD and non-alcoholic steatohepatitis (NASH). These factors include, but are not limited to, obesity, insulin resistance, hyperglycemia, and high levels of fat in the blood. The result is the accumulation of fat in hepatocytes that over time leads to inflammation and scarring of the

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Sassoon, Daniel Jay. "Obesity alters global response to ischemia and GLP-1 agonism." Diss., 2016. http://hdl.handle.net/1805/10980.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Glucagon-like peptide 1 (GLP-1) receptor agonists are a class of incretin based therapeutics which aid in blood glucose management in Type II diabetes mellitus (T2DM). Recent studies have demonstrated direct cardiovascular benefits conferred by these agents including protection in ischemia and heart failure. Despite these observations, human clinical trials fail to support improvements in cardiovascular outcomes independent of glucose lowering effects in the T2DM populations. Prior data from our lab demonstrate that obesi

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Costa, Lia Marques e. "Estudo dos efeitos protetores dos agonistas do receptor do GLP-1 na retinopatia diabética." Master's thesis, 2018. http://hdl.handle.net/10316/86205.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>A retinopatia diabética é uma das principais causas de perda de visão, incluindo cegueira, em indivíduos diabéticos em idade ativa, nos países desenvolvidos. Atualmente, os tratamentos disponíveis para a retinopatia diabética são direcionados para as fases mais avançadas da doença, em que a visão já se encontra comprometida. Estes tratamentos são invasivos, não sendo eficazes para todos os doentes, e possuem vários riscos associados, nomeadamente o de infeções como a endoftalmite infeciosa e o risco de de

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Lee, Mei-Yueh, and 李美月. "Effects of GLP-1 Receptor Agonist Liraglutide on Monocrotaline Induced Pulmonary Arterial Hypertension in Rat." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/9p49bh.

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碩士<br>高雄醫學大學<br>醫學系藥理學科研究所<br>102<br>Objectives: Glucagon-like peptide-1 receptor (GLP-1R) agonists are used to treat type 2 diabetes, and studies in animals and humans have explored the biological actions of GLP-1 on the myocardium and the vasculature, as well as on cardiovascular risk factors. However, the effect of GLP-1R agonist on pulmonary arterial hypertension (PAH), a syndrome that is a rare but incurable disease leading to progressive right heart failure and death, is unknown. In this study, we would like to investigate the pulmonary vasodilatory effects of liraglutide, the GLP-1 rece

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Murteira, Rodrigo Miguel Martins. "Eficácia e segurança dos agonistas GLP-1 no tratamento da diabetes mellitus tipo 2 : uma revisão sistemática." Master's thesis, 2015. http://hdl.handle.net/10451/27050.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015<br>Enquadramento: Os análogos peptídicos "glucagon-like" são uma nova classe de fármacos usada no tratamento da Diabetes Mellitus Tipo 2 (DMT2) que mimetizam a hormona endógena "glucagon-like peptide 1 (GLP-1). A GLP-1 regula os níveis de glucose através da estimulação da secreção de insulina duma forma glucose-dependente, diminuindo a secreção de glucagon, atrasando o esvaziamento gástrico e promovendo a saciedade. O tratamento individualizado da DMT2, usando vários agonistas dos

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Cunha, Sara Sofia da Silva. "O Potencial Terapêutico dos Agonistas do GLP-1R na Doença de Alzheimer." Master's thesis, 2018. http://hdl.handle.net/10316/84718.

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Relatório de Estágio do Mestrado Integrado em Ciências Farmacêuticas apresentado à Faculdade de Farmácia<br>A doença de Alzheimer é a doença neurodegenerativa mais comum e é caracterizadapela deterioração progressiva e irreversível das funções cognitivas. As principaiscaraterísticas histopatológicas da doença de Alzheimer compreendem a presença de placasamiloides extracelulares e de emaranhados neurofibrilares intracelulares. Apesar doconhecimento sobre a doença ser cada vez maior, ainda carece de uma terapêutica eficaz ecapaz de reverter ou, até mesmo, retardar a progressão da doença, constit

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