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Artykuły w czasopismach na temat „GPC-3”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Karihaloo, Anil, Sujata Kale, Norman D. Rosenblum, and Lloyd G. Cantley. "Hepatocyte Growth Factor-Mediated Renal Epithelial Branching Morphogenesis Is Regulated by Glypican-4 Expression." Molecular and Cellular Biology 24, no. 19 (2004): 8745–52. http://dx.doi.org/10.1128/mcb.24.19.8745-8752.2004.

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ABSTRACT The glypican (Gpc) family of cell surface heparan sulfate proteoglycans are expressed in a tissue-specific and developmentally regulated fashion. To determine if individual Gpcs can modulate heparin-binding growth factor signaling, we examined hepatocyte growth factor (HGF)-stimulated mitogenic, motogenic, and morphogenic responses of renal tubular cells expressing different Gpcs. Adult inner medullary collecting duct (IMCD) cells were found to express primarily Gpc4 and to proliferate, migrate, and form tubules with HGF, correlating with sustained extracellular signal-regulated kinas

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He, Wei, Yawei Du, Wenya Zhou, Chen Yao, and Xinsong Li. "Redox-sensitive dimeric camptothecin phosphatidylcholines-based liposomes for improved anticancer efficacy." Nanomedicine 14, no. 23 (2019): 3057–74. http://dx.doi.org/10.2217/nnm-2019-0261.

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Aim: A redox-triggered camptothecin (CPT) liposomal system was developed for an improved clinical potential in tumor therapy. Materials & methods: CPT–phosphorylcholine conjugates (CPT–SS–GPCs: CPT–SS–3–GPC and CPT–SS–11–GPC) were synthesized by conjugating CPT to glycerylphosphorylcholine via disulfide bond linker. CPT–SS–GPCs could be assembled into liposomes. Different in vitro and in vivo analyses were used to evaluate the anticancer activities of CPT–SS–GPCs. Results: CPT–SS–GPCs liposomes exhibited extremely high drug loading and uniform size of 150–200 nm. Moreover, the rapid releas

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Cao, Wenqing, Meenal Sharma, Rami Imam, and Jiangzhou Yu. "Study on Diagnostic Values of Astrocyte Elevated Gene 1 (AEG-1) and Glypican 3 (GPC-3) in Hepatocellular Carcinoma." American Journal of Clinical Pathology 152, no. 5 (2019): 647–55. http://dx.doi.org/10.1093/ajcp/aqz086.

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Abstract Objectives To investigate the diagnostic potential of AEG-1 and GPC-3 in hepatocellular carcinoma (HCC). Methods AEG-1 and GPC-3 immunohistochemistry were performed on HCC, adjacent nontumor tissue (ANT), and dysplastic nodules (DN). Results H score of AEG-1 or GPC-3 in HCC was significantly higher than in ANT or DN. In HCC, 92% and 54% showed AEG-1 and GPC-3 positivity, respectively. In ANT, 16.2% were AEG-1 and 7.6% GPC-3 positive. AEG-1 staining was mostly diffuse, whereas GPC-3 frequently showed focal staining. AEG-1 alone showed high sensitivity but low specificity and accuracy.

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Mauro, Montalbano, Perricone Ugo, Zachary Walton, Shirafkan Ali, Cristiana Rastellini, and Luca Cicalese. "Glypican-3 (GPC-3) Structural Analysis and Cargo in Serum Small Extracellular Vesicles of Hepatocellular Carcinoma Patients." International Journal of Molecular Sciences 24, no. 13 (2023): 10922. http://dx.doi.org/10.3390/ijms241310922.

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Glypican-3 (GPC-3) is a heparin sulfate proteoglycan located extracellularly and anchored to the cell membrane of transformed hepatocytes. GPC-3 is not expressed in normal or cirrhotic liver tissue but is overexpressed in hepatocellular carcinoma (HCC). Because of this, GPC-3 is one of the most important emerging immunotargets for treatment and as an early detection marker of HCC. To determine if GPC-3 domains associated with serum small extracellular vesicles (sEVs) could be used as an HCC diagnostic marker, we predicted in silico GPC-3 structural properties and tested for the presence of its

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5

Wu, Yongle, Hui Liu, and Hui-Guo Ding. "GPC-3 in hepatocellular carcinoma: current perspectives." Journal of Hepatocellular Carcinoma Volume 3 (November 2016): 63–67. http://dx.doi.org/10.2147/jhc.s116513.

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Shustov, G. R. "Reconstruction of point contact function of the electron–phonon interaction for contacts with a high background level." Soviet Journal of Low Temperature Physics 15, no. 4 (1989): 240–42. https://doi.org/10.1063/10.0032159.

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The effect of the finiteness of the phonon momentum mean free path lr on the form of the point-contact function (PCF) reconstructed from experimental data is investigated quantitatively for aluminum. The background level observed in experiments attains the values lr/d ∼ 10−2−10−3 (d is the characteristic size of a point contact), which is an indication of an effective accumulation of phonons in the contact region. In this case the PCF gpc(eV) reconstructed in the region of the L-maximum differs by ∼25% from the PCF reconstructed under the assumption that Lr/d = ∞. The point contact functions g

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7

Ssemwanga, Deogratius, Nicholas Bbosa, Rebecca N. Nsubuga, et al. "The Molecular Epidemiology and Transmission Dynamics of HIV Type 1 in a General Population Cohort in Uganda." Viruses 12, no. 11 (2020): 1283. http://dx.doi.org/10.3390/v12111283.

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The General Population Cohort (GPC) in south-western Uganda has a low HIV-1 incidence rate (<1%). However, new infections continue to emerge. In this research, 3796 HIV-1 pol sequences (GPC: n = 1418, non-GPC sites: n = 1223, Central Uganda: n = 1010 and Eastern Uganda: n = 145) generated between 2003–2015 were analysed using phylogenetic methods with demographic data to understand HIV-1 transmission in this cohort and inform the epidemic response. HIV-1 subtype A1 was the most prevalent strain in the GPC area (GPC and non-GPC sites) (39.8%), central (45.9%) and eastern (52.4%) Uganda. Howe

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8

Makkouk, Amani, Xue (Cher) Yang, Taylor Barca та ін. "Off-the-shelf Vδ1 gamma delta T cells engineered with glypican-3 (GPC-3)-specific chimeric antigen receptor (CAR) and soluble IL-15 display robust antitumor efficacy against hepatocellular carcinoma". Journal for ImmunoTherapy of Cancer 9, № 12 (2021): e003441. http://dx.doi.org/10.1136/jitc-2021-003441.

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BackgroundGlypican-3 (GPC-3) is an oncofetal protein that is highly expressed in various solid tumors, but rarely expressed in healthy adult tissues and represents a rational target of particular relevance in hepatocellular carcinoma (HCC). Autologous chimeric antigen receptor (CAR) αβ T cell therapies have established significant clinical benefit in hematologic malignancies, although efficacy in solid tumors has been limited due to several challenges including T cell homing, target antigen heterogeneity, and immunosuppressive tumor microenvironments. Gamma delta (γδ) T cells are highly cytoly

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9

Le Gouvello, S., E. Vivier, P. Debre, Y. Thomas, and O. Colard. "CD2 triggering stimulates the formation of platelet-activating factor-acether from alkyl-arachidonoyl-glycerophosphocholine in a human CD4+ T lymphocyte clone." Journal of Immunology 149, no. 4 (1992): 1289–93. http://dx.doi.org/10.4049/jimmunol.149.4.1289.

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Abstract A human CD4+ T lymphocyte clone synthesized platelet-activating factor (PAF) acether when stimulated via the CD2 pathway. PAF-acether was characterized by biochemical and biophysical properties and precursor-product relationships (alkyl-acyl-sn-glycero-3-phosphocholine (GPC)----alkyl-lyso-GPC (lyso-PAF)----PAF-acether) were demonstrated. The clone contained substantial amounts of alkyl-acyl-GPC. i) Hydrolysis of alkyl-acyl-GPC upon CD2 stimulation was evidenced: [3H]alkyl-lyso-GPC was formed from [3H]alkyl-acyl-GPC in [3H] alkyl-labeled cells; alkyl-lyso-GPC production was also bioass

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10

El-Naggar, Sabry Ali, Karim Samy El-Said, Mona Elwan, et al. "Toxicity of bean cooking media containing EDTA in mice." Toxicology and Industrial Health 36, no. 6 (2020): 436–45. http://dx.doi.org/10.1177/0748233719893178.

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The possible renal and hepatic toxicities of ethylenediaminetetraacetic acid (EDTA) in bean cooking media were studied using 100 male albino mice. Two sublethal doses of EDTA were used to explore their toxic effects; 20 mg/kg and 200 mg/kg, which corresponded to 1/100th and 1/10th of LD50, respectively. Accordingly, the toxicity study was performed using 50 mice, divided into five groups ( n = 10/group) as follows: group 1 (Gp1) served as a negative control and was orally administered normal saline; group 2 (Gp2) was administered the bean cooking medium; group 3 (Gp3) was administered EDTA (20

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11

Ikotun, Jacob O., Gbenga E. Aderinto, Makungu M. Madirisha, and Valentine Y. Katte. "Geopolymer Cement in Pavement Applications: Bridging Sustainability and Performance." Sustainability 16, no. 13 (2024): 5417. http://dx.doi.org/10.3390/su16135417.

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Abstract: Sustainability and the quest for a more robust construction material cannot be divorced from each other. While Portland cement has revolutionized the construction sector, its environmental toll, particularly in greenhouse gas emissions and global warming, cannot be ignored. Addressing this dilemma requires embracing alternatives like geopolymer cement/geopolymer binder (GPC/GPB). Over the last few decades, considerable strides have been achieved in advancing GPC as a sustainable construction material, including its utilization in pavement construction. Despite these advances, gaps st

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12

Triggiani, M., W. C. Hubbard, and F. H. Chilton. "Synthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine by an enriched preparation of the human lung mast cell." Journal of Immunology 144, no. 12 (1990): 4773–80. http://dx.doi.org/10.4049/jimmunol.144.12.4773.

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Abstract Our study has examined the synthesis of platelet activating factor (PAF; 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and of structurally related molecules by an enriched preparation (greater than 70%) of the human lung mast cell (HLMC) in response to immunologic stimulation. Upon activation with anti-IgE, HLMC incorporated exogenously provided acetate into a phospholipid that migrated with authentic PAF on TLC. The formation of this product in HLMC occurred concomitantly with histamine and leukotriene C4 release. Further analysis of this phospholipid revealed that 1-acyl-2-acetyl-

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13

Rahat, Noshaba, and Humera Shahzad. "Frequency of Immunohistochemical Marker GPC-3 Expression in Malignant Tumors." Pakistan Journal of Medical and Health Sciences 17, no. 6 (2023): 202–4. http://dx.doi.org/10.53350/pjmhs2023176202.

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Objective: To determine the frequency of immunohistochemical marker GPC-3 expression in malignant tumours in a tertiary care hospital. Material & Methods: This cross sectional study was conducted at the department of Histopathology, Dr. Ziauddin Medical University and Hospital, north campus, Karachi, a total of 114 cases of malignant tumours were enrolled using consecutive sampling technique in a period of six months from 1st April, 2012 to 30th September, 2012. Patients of both genders and all age groups of histologically diagnosed case of hepatocellular carcinoma (HCC) metastatic tumours

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Alekseeva, L. I., A. E. Karateev, E. Yu Pogozheva, V. N. Amirdzanova, E. S. Filatova, and V. A. Nesterenko. "Evaluation of the efficacy and safety of injectable glycosaminoglycan-peptide complex (GPC) in patients with osteoarthritis: a multicenter observational study GLADIOLUS (GPC in the treatment of osteoarthritis: a follow-up study of pain relief and local symptom reduction)." Modern Rheumatology Journal 14, no. 2 (2020): 76–83. http://dx.doi.org/10.14412/1996-7012-2020-2-76-83.

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Glycosaminoglycan-peptide complex (GPC) is a popular injectable extended-release symptomatic agent (ERSA) in Russia for the treatment of osteoarthritis (OA). To date, no large-scale studies of GPC used in real clinical practice have been conducted in our country.Objective: to evaluate the efficacy and safety of GPC in the treatment of OA in real clinical practice.Patients and methods. A multicenter observational non-interventional study was performed to evaluate the efficacy of GPC (Rumalon® , a cycle of intramuscular injections thrice weekly; a total of 25 injections). A study group consisted

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15

Long, Lam Minh, Nguyen Nang Dinh, and Tran Quang Trung. "Synthesis and Characterization of Polymeric Graphene Quantum Dots Based Nanocomposites for Humidity Sensing." Journal of Nanomaterials 2016 (2016): 1–6. http://dx.doi.org/10.1155/2016/5849018.

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Graphene quantum dots (GQDs) were synthesized and incorporated with polyethylenedioxythiophene:poly(4-styrenesulfonate) (PEDOT:PSS) and carbon nanotube (CNT) to form a composite that can be used for humidity sensors. The 600 nm thick composite films contained bulk heterojunctions of CNT/GQD and CNT/PEDOT:PSS. The sensors made from the composites responded well to humidity in a range from 60 to 80% at room temperature and atmospheric pressure. With a CNT content of 0.4 wt.% (GPC-1) to 0.8 wt.% (GPC-2) and 1.2 wt.% (GPC-3), the sensitivity of the humidity sensing devices based on CNT-doped graph

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16

Kim, Yeong Jin, Tae-Kyu Lee, Myung-Giun Noh, et al. "Effect of Choline Alphoscerate on the Survival of Glioblastoma Patients: A Retrospective, Single-Center Study." Journal of Clinical Medicine 11, no. 20 (2022): 6052. http://dx.doi.org/10.3390/jcm11206052.

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Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether GPC affects the overall survival (OS) and progression-free survival (PFS) of GBM patients. From 2011 to 2020, 187 isocitrate dehydrongenase (IDH)-wild-type GBM patients were analyzed. The patients were classified based on whether GPC was continuously used for at least 3 or 12 months (mos) after GBM

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Kim, Yeong Jin. "NCOG-14. EFFECT OF CHOLINE ALPHOSCERATE ON THE SURVIVAL OF GLIOBLASTOMA PATIENTS." Neuro-Oncology 25, Supplement_5 (2023): v216. http://dx.doi.org/10.1093/neuonc/noad179.0827.

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Abstract Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether GPC affects the overall survival (OS) and progression-free survival (PFS) of GBM patients. From 2011 to 2020, 187 isocitrate dehydrongenase (IDH)-wild-type GBM patients were analyzed. The patients were classified based on whether GPC was continuously used for at least 3 or 12 months (mos) a

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Tran, K., A. F. D'Angelo, P. C. Choy, and A. C. Chan. "Vitamin E enhances the acylation of 1-O-alkyl-sn-glycero-3-phosphocholine in human endothelial cells." Biochemical Journal 298, no. 1 (1994): 115–19. http://dx.doi.org/10.1042/bj2980115.

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1-O-Alkyl-2-acyl-sn-glycero-3-phosphocholine (alkylacyl-GPC) is the precursor of platelet-activating factor. It is formed via the CoA-independent transacylase reaction, which transfers the polyenoyl acyl group from the sn-2 position of a diacyl phospholipid to the sn-2 position of 1-O-alkyl-sn-glycero-3-phosphocholine (alkyl-GPC). We have reported previously that vitamin E alters phospholipid turnover in the endothelial cells by increasing arachidonic acid release and prostacyclin synthesis. In the present study, the role of vitamin E in the formation of alkylacyl-GPC was investigated. Incubat

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Telen, MJ, C. Le Van Kim, A. Chung, JP Cartron, and Y. Colin. "Molecular basis for elliptocytosis associated with glycophorin C and D deficiency in the Leach phenotype." Blood 78, no. 6 (1991): 1603–6. http://dx.doi.org/10.1182/blood.v78.6.1603.1603.

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Abstract Glycophorin C (GPC) and glycophorin D (GPD) are highly glycosylated integral membrane proteins of human erythrocytes encoded by the same gene and associated with expression of Gerbich blood group system antigens. GPC/D deficiency (the Leach phenotype) is a rare condition usually found after identification of Gerbich blood group system antibodies in persons undergoing prenatal or pretransfusion evaluation. In all cases, the Leach phenotype has been associated with elliptocytosis. Characterization of the molecular basis of this phenotype in three previously uninvestigated families has s

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Telen, MJ, C. Le Van Kim, A. Chung, JP Cartron, and Y. Colin. "Molecular basis for elliptocytosis associated with glycophorin C and D deficiency in the Leach phenotype." Blood 78, no. 6 (1991): 1603–6. http://dx.doi.org/10.1182/blood.v78.6.1603.bloodjournal7861603.

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Glycophorin C (GPC) and glycophorin D (GPD) are highly glycosylated integral membrane proteins of human erythrocytes encoded by the same gene and associated with expression of Gerbich blood group system antigens. GPC/D deficiency (the Leach phenotype) is a rare condition usually found after identification of Gerbich blood group system antibodies in persons undergoing prenatal or pretransfusion evaluation. In all cases, the Leach phenotype has been associated with elliptocytosis. Characterization of the molecular basis of this phenotype in three previously uninvestigated families has shown that

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I.M., Bank. "JUSTIFICATION OF THE NEED TO IMPROVE THE PROGRAM AND METHODOLOGICAL SUPPORT FOR THE TRAINING OF SPECIALISTS IN THE FIELD OF GRAPHIC DESIGN." Человеческий капитал, no. 4(172) (April 18, 2023): 134–40. http://dx.doi.org/10.25629/hc.2023.04.15.

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The article presents the results of a study of general cultural and professional competencies of students studying in the direction of graphic design, carried out in order to find ways to improve the program and methodological support for the training of specialists in this direction. It was established that the majority of students, both experimental and control groups, before the pedagogical experiment had a high level of formation of GPC-1 and GPC-5, an average level of development of GPC-2 and GPC-4, a low level of formation of GPC-3. В статье представлены результаты исследования общекульт

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Arinze, I. Aninworie MD MSc. "The Diagnostic Value Of Serum Glypican-3 In The Diagnosis Of Hepatocellular Carcinoma: A Systematic Review And Meta-Analysis." International Journal Of Health & Medical Research 02, no. 09 (2023): 274–88. https://doi.org/10.5281/zenodo.8362863.

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Background and aim: Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. It is curable in the early stages but has a poor prognosis when advanced. Current diagnostic protocols for the early stages of HCC are inefficient. Serum Glypican-3 (GPC-3) is a promising serum tumour marker in diagnosing HCC, and its diagnostic value has been explored in various studies. The outcomes, however, continue to be inconsistent and controversial. This systematic review and meta-analysis aimed to investigate the diagnostic accuracy of serum GPC-3 in hepatocellular carcin

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23

Verma, Saraswati, and Mayank Kumar. "Behaviour of Fly Ash and Rice Husk Ash Based Geopolymer Concrete." Key Engineering Materials 775 (August 2018): 596–602. http://dx.doi.org/10.4028/www.scientific.net/kem.775.596.

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Geopolymer Concrete (GPC) is a novel concrete which has evolved in recent decades. It uses industrial waste products like fly ash (FA), ground granulated blast slag (GGBS), Rice husk ash (RHA), micro-silica, and red mud etc., from industries, with alkaline liquids to replace cement in concrete by 100%, thereby developing an eco-friendly and sustainable construction material and simultaneously reducing waste disposal problem of fly ash and rice husk ash. GPC not only possesses excellent mechanical properties it also have very good durability properties. This paper presents the effect of partial

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KIM, Y. "P27.06.B EFFECT OF CHOLINE ALPHOSCERATE ON THE SURVIVAL OF GLIOBLASTOMA PATIENTS." Neuro-Oncology 26, Supplement_5 (2024): v137. http://dx.doi.org/10.1093/neuonc/noae144.468.

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Abstract BACKGROUND Cognitive impairment often occurs in glioblastoma (GBM) patients due to the tumor itself and treatment side effects. Choline alphoscerate (L-alpha-glycerylphosphorylcholine, GPC) is frequently used to compensate for cognitive impairment in GBM patients. This study was conducted to determine whether GPC affects the overall survival (OS) and progression-free survival (PFS) of GBM patients. MATERIAL AND METHODS From 2011 to 2020, 187 isocitrate dehydrongenase (IDH)-wild-type GBM patients were analyzed. The patients were classified based on whether GPC was continuously used for

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25

Makkouk, Amani, Xue (Cher) Yang, Taylor Barca та ін. "119 ADI-002: an IL-15 armored allogeneic ‘off-the-shelf’ Vδ1 gamma delta CAR T cell therapy for solid tumors targeting glypican-3 (GPC3)". Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A128. http://dx.doi.org/10.1136/jitc-2021-sitc2021.119.

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BackgroundGlypican-3 (GPC-3) is an oncofetal protein that is highly expressed in various solid tumors including hepatocellular carcinoma (HCC) but is rarely expressed in healthy adult tissues and serves as a therapeutic target of interest. Autologous αβ chimeric antigen receptor (CAR) T cell therapy has established clinical benefit in hematologic malignancies but limited success in solid tumors due to numerous challenges including poor T cell homing, heterogenous antigen expression, and hostile tumor microenvironments.1 These challenges may be overcome by the Vδ1 subset of gamma delta T cells

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MA Farag, Randa Mohamed, Dujana AlAyobi, Khalid A Alsaleh, Hye-Joo Kwon, Afaf EL-Ansary, and Emad Anwar Dawoud. "Influence of Glypican-3 as Anewly Diagnostic Biomarker in Earlydetection of Hepatocellular Carcinoma among Saudi Patients." Biomedical and Pharmacology Journal 11, no. 4 (2018): 1789–96. http://dx.doi.org/10.13005/bpj/1550.

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In Saudi Arabia AFP considered the main serum marker for diagnostic Hepatocellular carcinoma (HCC), due to the continuous detection of HCC in Saudi Arabia, using new biomarkers for early surveillance are essential to control in prevalence of HCC. The present study depend on compare the significant between serum and mRNA Glypican-3 (GPC-3) as newly identified diagnostic and prognostic biomarkers for HCC between study cases. And combined sensitivity of AFP and GPC-3. Three hundred study cases, divided into: 250 blood samples were 145 samples from HCC , 105 samples from chronic liver cirrhosis (C

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Ayoub, Noel, Andrew Thamboo, Peter H. Hwang, and Evan S. Walgama. "Radioanatomic Study of the Greater Palatine Canal Relevant to Endoscopic Endonasal Surgical Landmarks." Otolaryngology–Head and Neck Surgery 157, no. 4 (2017): 731–36. http://dx.doi.org/10.1177/0194599817711883.

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Objective A radioanatomic study of surgically relevant variations in the greater palatine canal (GPC) on computed tomography (CT) was performed to determine susceptibility during endoscopic endonasal procedures. Study Design Blinded radioanatomic analysis. Setting Tertiary university hospital. Subjects and Methods Fifty consecutive paranasal CT scans (100 sides) were analyzed. Measurements were standardized to landmarks such as the inferior turbinate (IT) and floor of the nasal cavity (FNC) to assess variability and vulnerability of the nerve. Measurements included (1) incidence of maxillary s

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Salomao, Marcela A., Sarah Short, Gloria Lee, Xiuli An, Mohandas Narla, and Joel Anne Chasis. "Aberrant Protein Sorting to the Nucleus during Erythroblast Enucleation: Mechanistic Basis for Membrane Protein Loss in Hereditary Elliptocytosis and Spherocytosis." Blood 108, no. 11 (2006): 1559. http://dx.doi.org/10.1182/blood.v108.11.1559.1559.

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Abstract During erythroblast enucleation, nuclei surrounded by plasma membrane separate from erythroblast cytoplasm. A key aspect of this process is sorting of membrane components to plasma membranes surrounding expelled nuclei and young reticulocytes. This protein partitioning performs a crucial role in regulating the protein content of reticulocyte plasma membranes. Although it is known that cytoskeletal actin, spectrin and protein 4.1R distribute to reticulocytes, little is known about the sorting patterns of erythroblast transmembrane proteins. In hereditary spherocytosis (HS) and heredita

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Моргун, Б., Н. Сандецька та Л. Великожон. "ДІЯ ГЕНА GPC-B1 НА ВМІСТ ПРОТЕЇНУ В ЗЕРНІ ПШЕНИЦІ М’ЯКОЇ ОЗИМОЇ НА ТЛІ ГЕНЕТИЧНОГО ОТОЧЕННЯ УКРАЇНСЬКИХ СОРТІВ". Science and Innovation 19, № 6 (2023): 31–39. http://dx.doi.org/10.15407/scine19.06.031.

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Вступ. Нагальною проблемою селекції пшениці є питання поліпшення якості зерна. Одним із напрямків генетичного поліпшення пшениці є перенесення генів від диких родичів. Особливий інтерес у цьому напрямку представляє ген Gpc-B1.Проблематика. Використання сучасних систем ДНК-маркерів для визначення гена Gpc-B1 від Triticum turgidum ssp. dicoccoides дасть можливість за короткий термін створити нові перспективні сорти-інновації з підвищеним вмістом протеїну у поєднанні з високими господарсько-цінними ознаками.Мета. Визначити ефективність дії гена Gpc-B1 в генетичному оточенні українського сорту ‘Ку

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Varghese, Bobby, Navid Darayan, Cristiana Rastellini, Luca Cicalese, and Mauro Montalbano. "New Immunological Approaches in Hepatocellular Carcinoma: Glypican-3 (GPC-3) Opportunities and Challenges." Journal of Cancer Therapy 11, no. 11 (2020): 647–59. http://dx.doi.org/10.4236/jct.2020.1111055.

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Hashem, Mohamed M., Nabil Salma Mohmuod, and Gamal Mohamed Soliman. "Role of Serum Glypican - 3 ( GPC-3 ) in Early Detection of Hepatocellular Carcenoma." Al-Azhar Medical Journal 44, no. 1 (2015): 101–8. http://dx.doi.org/10.12816/0015703.

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Mitra, J., and M. Chowdhury. "Association of glycerylphosphorylcholine with human sperm and effect of capacitation on their metabolism." Reproduction, Fertility and Development 6, no. 6 (1994): 679. http://dx.doi.org/10.1071/rd9940679.

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The presence and localization of glycerylphosphorylcholine (GPC) on the surface of human sperm, as well as the metabolism of its breakdown product L-glycerol 3 phosphate (G3P), were investigated. GPC was found to be associated with sperm after penetrating cervical mucus and was present after repeated washing of the sperm. GPC was partially released by treatment with 0.4 M NaCl in 0.01 M sodium phosphate buffer (pH 7.4) and localized to the head region after sperm fractionation. G3P did not increase O2 uptake of uncapacitated human sperm. However, under aerobic conditions, lactate accumulated w

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Salari, Hassan, Mervin Low, Sandra Howard, Glenn Edin, and Robert Bittman. "l-O-Hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine inhibits diacylglycerol kinase in WEHI-3B cells." Biochemistry and Cell Biology 71, no. 1-2 (1993): 36–42. http://dx.doi.org/10.1139/o93-006.

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The effects of 1-O-hexadecyl-2-O-methyl-sn-glycero-3-phosphocholine (ET-16-OCH3-GPC) and its metabolite 1-O-hexadecyl-2-O-methyl-sn-glycerol (AMG) on the activity of diacylglycerol kinase (DGK) in WEHI-3B cells were investigated. Treatment of WEHI-3B cells with 200 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) for 5 min leads to the activation of cytosolic DGK without significant effect on microsomal DGK. When these cells were first exposed to 50 μM ET-16-OCH3-GPC for 30 min prior to activation with TPA, the activity of DGK was inhibited by about 70%, as measured by the ability of enzyme to fo

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Kinugawa, Tomoya, Takashi Nakamura, and Hiroyuki Nakano. "Formation of binary black holes similar to GW190521 with a total mass of ∼150 M⊙ from Population III binary star evolution." Monthly Notices of the Royal Astronomical Society: Letters 501, no. 1 (2020): L49—L53. http://dx.doi.org/10.1093/mnrasl/slaa191.

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ABSTRACT In the case of zero-metal (Population III or Pop III) stars, we show that the total mass of binary black holes from binary Pop III star evolution can be ${\sim} 150 \, \mathrm{ M}_{\odot }$, which agrees with the mass of the binary black hole GW190521 recently discovered by LIGO/Virgo. The event rate of such binary black hole mergers is estimated as 0.13–0.66 (ρSFR/(6 × 105 M⊙ Mpc−3)) Errsys yr−1 Gpc−3, where ρSFR and Errsys are the cumulative comoving mass density of Pop III stars depending on star formation rate and the systematic errors depending on uncertainties in the Pop III bin

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Triggiani, M., R. P. Schleimer, J. A. Warner, and F. H. Chilton. "Differential synthesis of 1-acyl-2-acetyl-sn-glycero-3-phosphocholine and platelet-activating factor by human inflammatory cells." Journal of Immunology 147, no. 2 (1991): 660–66. http://dx.doi.org/10.4049/jimmunol.147.2.660.

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Abstract The synthesis of platelet-activating factor (PAF) and of the 1-acyl analogue of PAF, 1-acyl-2-acetyl-sn-glycero-3-phosphocholine (1-acyl-2-acetyl-GPC) was examined in seven human cell preparations (lung mast cell, basophil, endothelial cell, neutrophil, eosinophil, lung macrophage, platelet) and in human lung fragments. Cells were activated by either an appropriate receptor-mediated stimulus or by ionophore A23187 in the presence of [3H]acetate. All cell types, with the exception of the platelet, responded to stimulation with at least a twofold increase in the formation of labeled 1-r

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José, María Rumbo-Prieto, Santiago Cortizas Rey Juan, Lago López Rafael, Cabanas Polo Mercedes, Pérez Villaverde Paula, and Sánchez Gálvez Javier. "Evaluación AGREE-II de guías de práctica clínica sobre radiodermatitis aguda. [AGREE-II evaluation of clinical practice guidelines in acute radiodermatitis]." Enfermería Dermatológica 11, no. 50 (2017): 50–56. https://doi.org/10.5281/zenodo.1473066.

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<strong>RESUMEN</strong>: <strong>Objetivo:</strong> Evaluar y comparar la calidad de las guías de práctica clínica (GPC) sobre prevención y tratamiento de la radiodermatitis aguda (RDA). <strong>Metodología</strong>: Evaluación de la calidad metodoló- gica mediante el instrumento AGREE-II. Búsqueda de GPC en fuentes especializadas. Selección de GPC-RDA con antigüedad no superior a 5 años. Revisión por 3 evaluadores. <strong>Resultados: </strong>De siete GPC localizadas se seleccionaron 3 (dos mexi

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Zhang, Song, Jiangbo Jing, Lingchen Meng, Bin Xu, Xibo Ma, and Wenjing Tian. "Peptide-Conjugated Aggregation-Induced Emission Fluorogenic Probe for Glypican-3 Protein Detection and Hepatocellular Carcinoma Cells Imaging." Chemosensors 10, no. 5 (2022): 195. http://dx.doi.org/10.3390/chemosensors10050195.

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Hepatocellular carcinoma (HCC) is a malignant tumor with high morbidity and mortality on a global scale, and the development of accurate detection and imaging methods for HCC cells is urgently needed. Herein, by connecting peptide L5, which can specifically bind to the overexpressed Glypican-3 (GPC-3) protein of HCC cells with aggregation-induced emission (AIE) moiety ammonium cation-functionalized 9,10-distyrylanthracene (NDSA) via the “click” reaction, we synthesized a fluorescent probe NDSA-L5. In an aqueous solution, the probe shows weak emission, whereas, in the presence of the GPC-3 prot

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Nguyen, Tu T., Pham Thanh Tung, and Kobir Hossain. "Evaluation of modulus of elasticity for eco-friendly concrete made with seawater and marine sand." Journal of Science and Technology in Civil Engineering (STCE) - HUCE 15, no. 4 (2021): 148–56. http://dx.doi.org/10.31814/stce.huce(nuce)2021-15(4)-13.

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The ultimate aim of this study is to use experimental work for evaluating the modulus of elasticity (MOE) of Geopolymer concrete (GPC) using marine sand as fine aggregate and seawater for the mix. Four different groups of concrete mixtures, namely CP1a, CP1b, CP2a, CP2b were identified. While the CP1a mix was prepared using GPC with marine sand and seawater, the CP1b was made by adding sodium sulfate (Na2SO4) into the CP1a mix. The same procedure was applied for CP2a and CP2b mixtures; however, instead of using GPC, Portland Cement was used as the binder for the CP2 group (OPC). A total of 12

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Blumenfeld, J. D., S. C. Hebert, C. W. Heilig, J. A. Balschi, M. E. Stromski, and S. R. Gullans. "Organic osmolytes in inner medulla of Brattleboro rat: effects of ADH and dehydration." American Journal of Physiology-Renal Physiology 256, no. 5 (1989): F916—F922. http://dx.doi.org/10.1152/ajprenal.1989.256.5.f916.

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Inner medullary methylamine [glycerophosphorylcholine (GPC) and glycine betaine (betaine)] and polyol [sorbitol and myo-inositol (inositol)] osmolytes were measured in water-restricted and antidiuretic hormone (ADH)-infused Brattleboro (DI) rats. Compared with DI rats allowed water ad libitum, rats dehydrated for 3 days had higher urinary osmolality (Uosmol) (812 vs. 239 mosmol/kgH2O) and plasma osmolality (Posmol) (333 vs. 296 mosmol/kgH2O). Dehydration reduced betaine content (36 vs. 66 nmol/mg protein) but had no significant effect on GPC, sorbitol, or inositol. In separate protocols, DI ra

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McKenzie, R. H., E. Bremer, C. A. Grant, A. M. Johnston, J. DeMulder, and A. B. Middleton. "In-crop application effect of nitrogen fertilizer on grain protein concentration of spring wheat in the Canadian prairies." Canadian Journal of Soil Science 86, no. 3 (2006): 565–72. http://dx.doi.org/10.4141/s05-026.

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Due to the price premium for high-protein wheat (Triticum aestivum L.), many producers are interested in the efficacy of in-crop application of low rates of N fertilizer for increasing grain protein concentration (GPC). We conducted field studies at 26 site-years in Alberta, Saskatchewan and Manitoba from 1998 to 2000 to determine if in-crop application (tillering, boot stage or anthesis) of N fertilizer [broadcast ammonium nitrate (AN) or foliar urea-ammonium-nitrate solution (UAN); 15 kg N ha-1] could economically increase GPC of a Canada Western Red Spring (CWRS) wheat cultivar (AC Barrie).

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Zaslavsky, Alexander, Mackenzie Adams, Sandra Wissmueller, et al. "Glypican-1 as a novel immunotherapeutic target in prostate cancer." Journal of Clinical Oncology 36, no. 6_suppl (2018): 174. http://dx.doi.org/10.1200/jco.2018.36.6_suppl.174.

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174 Background: New effective therapies for men with prostate cancer are desperately needed. Recently, cancer immunotherapy has emerged as an important new treatment strategy for prostate cancer and for castrate resistant prostate cancer (CRPC). Multiple studies have identified the heparan sulfate proteoglycan-1 Glypican 1 (GPC-1) as being overexpressed in different cancers, and also as being a possible marker of poor prognosis in several solid tumor cancers. GPC-1 has been recently identified as a potential marker for prostate cancer. The MIL-38 monoclonal antibody detects GPC-1 and an IgG1 c

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Klypin, Anatoly, and Francisco Prada. "Effects of long-wavelength fluctuations in large galaxy surveys." Monthly Notices of the Royal Astronomical Society 489, no. 2 (2019): 1684–96. http://dx.doi.org/10.1093/mnras/stz2194.

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ABSTRACT In order to capture as much information as possible large galaxies surveys have been increasing their volume and redshift depth. To face this challenge theory has responded by making cosmological simulations of huge computational volumes with equally increasing numbers of dark matter particles and supercomputing resources. Thus, it is taken for granted that the ideal situation is when a single computational box encompasses the whole volume of the observational survey, e.g. $\sim 50\, h^{-3}\,{\rm Gpc}^3$ for the DESI and Euclid surveys. Here we study the effects of missing long waves

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Tabernero, Josep, Alberto F. Sobrero, Christophe Borg, et al. "Exploratory analysis of the effect of FTD/TPI in patients treated in RECOURSE by prognostic factors." Journal of Clinical Oncology 37, no. 4_suppl (2019): 677. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.677.

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677 Background: The Phase III RECOURSE trial, in patients (pts) with metastatic colorectal cancer (mCRC) refractory to standard therapies, demonstrated that trifluridine/tipiracil (FTD/TPI) significantly extended overall survival (OS) and progression-free survival (PFS) versus placebo in all subgroups, regardless of age, geographical origin, or KRAS status, with acceptable safety. Literature reports have shown optimal benefit for pts with low tumor burden (< 3 metastatic sites), indolent disease (≥ 18 mo since diagnosis of first metastasis), ECOG PS 0-1, and no liver metastasis when treated

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Mada, Ridwan. "Rancang Bangun Prototipe Sistem Monitoring Sinkronisasi Generator ke Jaringan PLN pada PLTM Berbasis SCADA." Jurnal Teknologi dan Rekayasa Manufaktur 5, no. 1 (2023): 35–50. http://dx.doi.org/10.48182/jtrm.v5i1.123.

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Sistem pembangkit listrik pada umumnya terdiri dari peralatan untuk membangkitkan listrik, sistem kontrol dan sistem monitoring. Sistem monitoring terletak di control room yang lokasinya cukup jauh dari peralatan pembangkit, sehingga menggunakan SCADA (Supervisory Control and Data Acquisition) sebagai solusi untuk hal tersebut. Pada penelitian ini dilakukan pembuatan rancang bangun prototipe sistem monitoring sinkronisasi generator ke jaringan PLN pada PLTM (Pembangkit Listrik Tenaga Mini Hidro) berbasis SCADA. Sistem SCADA menyajikan data dalam bentuk grafik dan tulisan yang nilainya berupa d

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Tehrani, Hamed Azhdari, Masood Zangi, Mobina Fathi, et al. "GPC-3 in hepatocellular carcinoma; A novel biomarker and molecular target." Experimental Cell Research 444, no. 2 (2025): 114391. https://doi.org/10.1016/j.yexcr.2024.114391.

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Peterson, D. P., K. M. Murphy, R. Ursino, K. Streeter, and P. H. Yancey. "Effects of dietary protein and salt on rat renal osmolytes: covariation in urea and GPC contents." American Journal of Physiology-Renal Physiology 263, no. 4 (1992): F594—F600. http://dx.doi.org/10.1152/ajprenal.1992.263.4.f594.

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Renal medullary cells contain high levels of (glycine) betaine, glycerophosphorylcholine (GPC), myo-inositol, and sorbitol. Two functions of these have been proposed: 1) that they are compatible osmolytes which regulate cell volume (against high external NaCl) without inhibiting proteins and 2) that methylamines (GPC and betaine) are counteracting osmolytes which stabilize proteins against perturbation from high renal urea. As a test of the latter, osmolyte contents in kidney medullas were measured in rats subjected to three types of dietary manipulation: 1) diets with protein and NaCl content

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Maphosa, Lancelot, Nicholas C. Collins, Julian Taylor, and Diane E. Mather. "Post-anthesis heat and a Gpc-B1 introgression have similar but non-additive effects in bread wheat." Functional Plant Biology 41, no. 9 (2014): 1002. http://dx.doi.org/10.1071/fp14060.

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High temperatures during grain filling can reduce the yield of wheat and affect its grain protein concentration. The Gpc-B1 locus of wheat also affects grain protein concentration, but it is not known whether its effects interact with those of heat. The aim of this study was to investigate the effects of high temperature in lines with and without functional (high-protein) alleles at Gpc-B1. A highly replicated experiment was conducted in a glasshouse under control conditions (24/18°C, 14/10 h day/night), with half of the plants of each line or cultivar put into a heat chamber (37/27°C, 14/10 h

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Park, Jihun, Seungjae Lee, Gyungtak Kim, Yashwardhan R. Malpani, Boyoung Y. Park та Ye-Jin Hwang. "Flow Synthesis of L-α-Glycerylphosphorylcholine: Studies on Synthetic Routes Applicable to a Flow Reactor and Optimization of Reaction Conditions". Pharmaceutics 14, № 11 (2022): 2480. http://dx.doi.org/10.3390/pharmaceutics14112480.

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L-α-Glycerylphosphorylcholine (L-α-GPC) has mainly been produced by two methods: extraction from plants rich in phosphatidylcholine and chemical synthesis. However, production through extraction involves difficult processes, such as fermentation, extractions and ripening, and conventional chemical synthesis methods with high-cost reactants and a batch reactor. These methods are not ideal for large-quantity production. Thus, it is important to develop a simple production method of L-α-GPC, which is suitable for mass production without the need for expensive reactants. Here, we studied synthetic

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Quispe-Pacheco, Measee Carolina, Valeria María Praeli-Meza, Claudia Gutiérrez-Ortiz, Carolina Válerie Sarria-Arenaza, and Isabel Angélica Pinedo-Torres. "Guía de práctica clínica para el manejo de Diabetes Mellitus Tipo 2 en pacientes con falla cardiaca del Hospital Nacional Daniel Alcides Carrión (Callao, Perú)." Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo 15, no. 1 (2022): 108–17. http://dx.doi.org/10.35434/rcmhnaaa.2022.151.1261.

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Objetivo: Emitir recomendaciones para el manejo de la diabetes en pacientes con falla cardiaca, contextualizadas al Hospital Nacional Daniel Alcides Carrión (HNDAC) del Callao, Perú. Material y métodos: Se buscó sistemáticamente las GPC publicadas en los últimos 3 años en bases de datos, repositorios y organismos elaboradores. Se seleccionó aquellas que alcancen un puntaje >60% en la evaluación global con el instrumento AGREE-II. De cada guía se extrajeron las recomendaciones con sus respectivas preguntas clínicas. La aceptabilidad y aplicabilidad de las recomendaciones al contexto del HNDA

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Triggiani, M., A. N. Fonteh, and F. H. Chilton. "Factors that influence the proportions of platelet-activating factor and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine synthesized by the mast cell." Biochemical Journal 286, no. 2 (1992): 497–503. http://dx.doi.org/10.1042/bj2860497.

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Recent studies have demonstrated that inflammatory cells can be divided into two groups depending on the type of 2-acetylated phospholipids [1-radyl-2-acetyl-sn-glycero-3-phosphocholine (GPC)] they produce: those that produce predominantly platelet-activating factor (PAF), and those that produce predominantly its 1-acyl analogue (1-acyl-2-acetyl-GPC; AAGPC) [Triggiani, Schleimer, Warner & Chilton (1991) J. Immunol. 147, 660-666]. The present study has examined the factors that regulate the production of these two molecules in mouse bone marrow-derived mast cells (BMMC). Initial experiments

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