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Rozprawy doktorskie na temat „Gram-Negative Pathogen”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Abdullah, Abdallah Ibansharred. "Virulence determinants of aeromonads and other gram-negative bacteria." Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275038.

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Chan, Anson Chi-Kit. "Iron transport in two pathogenic Gram-negative bacteria." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/32406.

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Campylobacter jejuni and Escherichia coli strain F11 are two Gram-negative pathogens with a versatile armament of iron uptake systems to cope with the fluctuating host nutrient environment. Our current understanding of Gram-negative iron uptake systems focuses heavily on a prototypical scheme involving a TonB-dependent outer membrane receptor and an ABC transporter, with little knowledge on systems that do not fall neatly into this paradigm. The primary focus of this thesis is the characterization of three such atypical iron uptake proteins from C. jejuni (ChaN and P19) and pathogenic E. coli

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Lynch, Martin J. "Quorum sensing in Aeromonas hydrophila biofilm formation." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324695.

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Grape, Malin. "Molecular basis for trimethoprim and sulphonamide resistance in Gram negative pathogens /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-870-3/.

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Gillette, Devyn Dior. "Characterization of Inadequate Host Responses to Intracellular Gram-negative Bacterial Pathogens." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385465357.

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Gonciarz, Ryan Lennox. "Broadening the spectrum of antibacterial agents to tackle multidrug-resistant Gram-negative pathogens." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22308/.

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Antimicrobial resistance is one of the greatest threats to human health in the 21st century: particularly resistance amongst Gram-negative bacteria. The work presented herein aims to identify new agents that target drug-resistant Gram-negative pathogens such as E. coli, through the rational modification of the oxazolidinone class of antibiotics. This class, exemplified by linezolid, is well validated for treating Gram-positive derived infections, but lacks clinically-useful activity against Gram-negative bacteria. An integrated approach encompassing structure-based drug design, organic synthes

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Willsey, Graham Geier. "Detection Of The Lung Environment By Multi-Drug Resistant Gram-Negative Bacterial Pathogens." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/978.

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Nosocomial lung infections are a growing concern in the United States, with more than 300,000 cases reported annually. More than 30 % of which are caused by the Gram-negative bacteria, Pseudomonas aeruginosa and Klebsiella pneumoniae. Similarly, Gram-negative bacteria establish chronic infections in individuals with cystic fibrosis (CF) that are difficult or impossible to eradicate.P. aeruginosa has historically been one of the most prevalent pathogens of adults with CF. However, as antipseudomonal therapy has improved, more antibiotic resistant species have taken hold, including Stenotrophomo

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8

Ricchetti, Beatrice <1988&gt. "Understanding and exploiting lipoprotein translocation in Gram negative pathogens for improved vaccine antigen delivery platforms." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amsdottorato.unibo.it/8517/1/Phd%20thesis_beatrice%20Ricchetti_v3.pdf.

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Lipoproteins of pathogenic Gram-negative bacteria are involved in different biological processes due to their highly immunogenic nature; and have proven to be good vaccine antigens. The lipoprotein translocation machinery of model organisms such as Escherichia coli is well characterized but unlikely E. coli, N. meningitidis displays many lipoproteins on its surface and recently an additional translocation component, Surface lipoprotein assembly modulators, involved in the surface exposure of specific N. meningitidis lipoproteins, has been identified. Several aspects were investigated: the sort

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9

Romoli, Ottavia. "Antimicrobial peptide-mediated immune response in four Bombyx mori strains infected with Gram-positive and -negative pathogens." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3424450.

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The domesticated silkworm Bombyx mori is an important organism for its intrinsic economic and biotechnological value, but also for representing a model organism for Lepidoptera genetics. Silkworm strains can be grouped into four geographical types (Japanese, Chinese, European and Tropical) characterized by a different resistance to infections, which is inversely correlated to the silk productivity. The aim of this project was to characterize which are the main elements of the immune response protecting Bombyx mori against pathogen infections, with the final purpose to obtain silkworms enhance

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10

De, Lamo Castellví Sílvia. "Behaviour of pathogenic gram negative bacteria inoculated in milk and model cheese treated with high hydrostatic pressure." Doctoral thesis, Universitat Autònoma de Barcelona, 2006. http://hdl.handle.net/10803/5672.

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Els efectes de les altes pressions hidrostàtiques i la capacitat per sobreviure, recuperar-se i créixer de tres microorganismes patògens (Yersinia enterocolitica, Escherichia coli Salmonella enterica) van ser investigats en llet desnatada i en un formatge model elaborat amb i sense estàrter. Les mostres inoculades amb aquests microorganismes, van ser tractades a 300, 400 i 500 MPa (exceptuant les mostres inoculades amb soques de S. enterica) durant 10 minuts a 20ºC o a temperatura ambient i van ser analitzades microbiològicament just després d'aplicar el tractament d'altes pressions i als 1, 2

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11

Akter, Asma. "UV mutagenesis to unlock cryptic secondary metabolism in streptomycetes, and the identification of novel antibiotics against Gram-negative pathogens." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20693/.

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Nyenje, Mirriam E. "Phytochemical analysis and bioactivity of the stem bark of Combretum Molle on some selected bacterial pathogens." Thesis, University of Fort Hare, 2011. http://hdl.handle.net/10353/391.

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Antimicrobial resistance is a worldwide problem that has deleterious long-term effects as the development of drug resistance outpaces the development of new drugs. Plants have been used for many generations for healing purposes, and screening of extracts of these plants has often yielded positive outcomes. This study was aimed at isolating and characterizing the major active antimicrobial compounds present in the stem bark of C. molle, in a bid to identify potential sources of cheap starting materials for the synthesis of new drugs. Various solvents (hexane, ethyl acetate, dichloromethane, ace

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13

Hill, Emily M. "Emerging Pathogens in Cystic Fibrosis Patients at Virginia Commonwealth University Medical Center (VCUMC)." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4606.

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Cystic fibrosis (CF) is an autosomal recessive disorder affecting 70,000 individuals worldwide. This disease is characterized by the buildup of mucus in the airways leading to chronic lung infections resulting in pulmonary failure and death in 95% of CF patients. Routine surveillance of CF pathogens using traditional microbiology culture guides management and treatment of CF patients. Molecular profiling studies have revealed emerging pathogens that may play a role in CF lung disease by either directly causing infection or upregulating the virulence factors of classic CF pathogens, such as P.

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14

Du, Dijun. "Elucidation of the structure and molecular mechanism of the tripartite multidrug efflux pumps in the gram-negative pathogens, Vibrio cholerae and Neisseria gonorrhoeae." Thesis, Durham University, 2006. http://etheses.dur.ac.uk/2619/.

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In bacteria, multidrug efflux systems have been identified as significant determinants of resistance recently. These resistance pumps are widely distributed in bacterial species and many pathogenic bacteria posses them, which play an important role in their intrinsic and acquired multidrug resistances. The RND and MATE family transporters have also been shown to be involved in the pathogenicity of bacteria. Knowledge of the structure and mechanism of these transporter proteins would be exceedingly useful in the design of inhibitors. In Gram-negative bacteria, multidrug resistance is conferred

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15

Singh, Sanjesh. "Investigation of Gram-negative bacterial surface glycans: characterisation of Moraxella bovis lipooligosaccharide and progress towards developing a Nontypeable Haemophilus influenzae/Moraxella catarrhalis vaccine candidate." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/388637.

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Moraxella bovis, Moraxella catarrhalis and Nontypeable Haemophilus influenzae (NTHi) are Gram-negative, oxidase positive, pathogenic microorganisms. M. bovis causes Infectious Bovine Keratoconjunctivitis, known (IBK) as ‘pink-eye’ in cattle worldwide. The disease is of economic importance as it leads to substantial economic loss in the cattle and dairy industries. There are antibiotic treatments available to treat M. bovis associated infections, but they tend to be ineffective at controlling disease outbreaks. Importantly, the current series of antibiotics used to treat IBK have shown occurren

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16

Wright, Claire Louise. "Investigation of the prevalence of opportunistic gram negative pathogens in the water supply of a haematology unit, and the application of point-of-use filtration as an intervention." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5692.

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Gram-negative infection has been linked to hospital water although few studies have examined whether water systems are reservoirs of nosocomial pathogens. This study investigated longitudinal recovery of the opportunistic pathogens Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Acinetobacter baumannii from water outlets of a haematology unit and evaluated Point-Of-Use Filtration (POU-F) as a control measure. In a two-year double cross-over trial, water samples and swabs were taken weekly from 39 showers/taps on the unit. Four study phases alternated between non-filtered (Phases 1 &am

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17

Balder, Rachel. "Type V Secretion System Exoproteins and their Roles in the Adherence of the Gram-Negative Bacterial Pathogens Moraxella catarrhalis, Burkholderia pseudomallei and Burkholderia mallei." University of Toledo Health Science Campus / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=mco1188909479.

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18

Adeyemi, Oluwatosin Oluwakemi. "Comparative in-vitro activities of trimethoprimsulfamethoxazole and the new fluoroquinolones against confirmed extended spectrum beta-lactamase producing Stenotrophomonas maltophilia in Nkonkobe Municipality, Eastern Cape environment." Thesis, University of Fort Hare, 2012. http://hdl.handle.net/10353/d1007576.

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Stenotrophomonas maltophilia is increasingly emerging as an opportunistic pathogen of global concern. Due to its inherent resistance to several classes of antibiotics including carbapenems and its ability to acquire mobile resistance elements, treatment of infections caused by S. maltophilia is a constant challenge for clinicians. Trimethoprim-sulphamethoxazole (TMP-SMX) is the generally accepted antibiotic of choice for the treatment of infections caused by this organism, but resistance to the drug is increasingly being reported; hence, the need for alternative therapeutic options. In this st

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Trinh, Thi Trang Nhung. "Structural studies of type IX and type II secretion systems." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0089.

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Les protéines synthétisées et sécrétées par les bactéries jouent des rôles importants pour leur survie. Les bactéries à Gram négatif ont développé des voies de sécrétion en tant qu'armes principales pour transporter des facteurs de virulence dans l'environnement extracellulaire ou dans des cellules hôte. L'un de ces systèmes, le T9SS a été principalement étudié chez l'agent pathogène oral Porphyromonas gingivalis et chez la bactérie mobile Flavobacterium johnsoniae. Un autre complexe, le T2SS est le principal déterminant de la virulence de la bactérie Pseudomonas aeruginosa, un agent pathogène

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20

Gómez-Zorrilla, Martín Silvia. "Impacto de la multirresistencia en la patogenicidad de Pseudomonas aeruginosa: perspectiva epidemiológica-clinica y experimental." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/401750.

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P. aeruginosa es uno de los principales patógenos nosocomiales y posee una gran capacidad de desarrollar resistencias a los antimicrobianos con la emergencia de cepas multirresistentes (MDR) y extremadamente resistentes (XDR). En las últimas décadas se ha producido un incremento de las infecciones por cepas multirresistentes que plantea la necesidad de desarrollar estrategias de control de infección y un uso prudente de los antimicrobianos. En este contexto se desarrolla la presente tesis doctoral en la que se incluyen ocho trabajos publicados en revistas científicas, que están encaminados tan

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21

Shung, Chang Wu, and 張吳順. "Randomly Cloned DNA Probe for Identification of Gram negative Periodontal Pathogen of Prevotella intermedia." Thesis, 1993. http://ndltd.ncl.edu.tw/handle/20541364373289291731.

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22

Kumar, Sumith. "Exploring the Roles of Phase Variable HpyAII Restriction-modification System in the Human Pathogen Helicobacter pylori." Thesis, 2016. http://etd.iisc.ac.in/handle/2005/4069.

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Helicobacter pylori is a Gram-negative microaerophilic bacteria known to infect as much as 80% of some populations with an average morbidity range of around 50% of the world population. It has been recognized as a definitive carcinogen (Type I). H. pylori shows extraordinary genetic diversity and this property is critical to its success as a human pathogen. High genetic diversity and interstrain variations seen in H. pylori is attributed to its remarkable ability to take foreign DNA by natural transformation. Natural transformation in H. pylori is governed to some extent by the presence of Res

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Mgcina, Londiwe Siphephise. "Comparison between conventional and quantum dot labeling strategies for LPS binding studies in Arabidopsis thaliana." Thesis, 2013. http://hdl.handle.net/10210/8739.

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M.Sc. (Biochemistry)<br>Lipopolysaccharide (LPS) is a complex lipoglycan that is found in the outer membrane of Gram-negative bacteria and is composed of three regions namely the fatty acid Lipid A, a core region of short oligosaccharide chains and an O-antigen region of polysaccharides. When LPS is recognized as a microbe-/pathogen-associated molecular pattern (M/PAMP), it not only induces an innate immune response in plants but also stimulates the development of defence responses such as the immediate release of reactive oxygen species/intermediates (ROS/I), pathogen-related (PR) gene expres

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Lucas, Joana Teixeira da Costa. "Novel strategies to combat gram-negative bacterial pathogens using bacteriophage proteins." Master's thesis, 2015. http://hdl.handle.net/1822/41410.

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Dissertação de mestrado em Bioengenharia<br>The infections caused by Gram-negative pathogens are a concern to global health, resulting in high rates of morbidity, mortality and high costs in health care. Once formed, biofilms cause reduction of host defenses and increase resistance to antimicrobial products 10 to 1000 times more than the cells in their planktonic state. According to recent studies, in 2050, bacterial infections, associated with the growing resistance of pathogens to antimicrobial agents, will cause more than 300 million premature deaths and a loss of € 90 trillion to the glob

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BIANCALANI, CAROLA. "Anti-infective environmentally friendly molecules against plant pathogenic Gram-negative bacteria." Doctoral thesis, 2017. http://hdl.handle.net/2158/1087786.

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The market globalisation and the climate change are contributing substantially to the possible and rapid spread of alien and invasive plant pathogens in areas where they were previously absent, or are intensifying the incidence and severity of endemic pathogens, thus contributing significantly to increase the possible threats to the agricultural sector. Moreover, the lack of effective alternative molecules to copper compounds in plant protection, whose negative effects on both human health and environmental protection, have been neglected for far too long, and the need to adapt to European leg

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Huang, Hsin-I., and 黃欣儀. "In Vitro Efficacy of Copper and Silver Ions in Eradicating Gram Negative Waterborne Pathogens." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/59158576770380557155.

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碩士<br>國立高雄師範大學<br>環境教育研究所<br>92<br>Abstract Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Acinetobacter baumannii are opportunistic pathogens that are found in potable water systems. Hospital water supplies have been epidemiologically linked as sources for nosocomial respiratory infection. Ionization has been shown to be an effective method for controlling Legionella in hospital hot water systems at 0.2-0.8 mg/L of copper and 0.02-0.08mg/L of silver; however, the effect of copper and silver ions on P. aeruginosa, S. maltophilia and A. baumannii is unknown. The objective

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Ememu, Ejovwoke F. "Antagonism of Serratia plymuthica against Gram negative food-borne pathogens (Escherichia coli O157:h7 and Salmonella Enteritidis)." 2011. https://scholarworks.umass.edu/theses/557.

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Bacteriocins are antimicrobial protein produced by certain Gram positive and negative bacteria as a defense mechanism against closely related bacteria competing for the same nutrient or in the same niche. The competition for the same nutrient is supported by the fact that bacteriocins have narrow range of effect and only likely to be effective against closely related bacteria for the same scares resources hence a bacteriocin produced by a Gram positive bacteria will be active against a Gram positive pathogens and a bacteriocin produced by a Gram negative bacteria will be active against Gram ne

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Chen, Sz-Rung, and 陳思蓉. "Studies on antimicrobial activities of lactoferrin hydrolysates in combinational use with nisin against Gram-negative food pathogens." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/jc2m5v.

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碩士<br>國立宜蘭大學<br>食品科學系碩士班<br>105<br>Nisin is the natural food preservatives, it can inhibit gram-positive bacteria (G (+)), but Gram-negative bacteria (G (-)) demonstrated no significant inhibition. However previous studies has found Nisin combining other antimicrobial substances can enhance antibacterial effect against G (-) bacteria. Lactoferrin (Lf), an iron-binding glycoprotein found in mammalian exocrine secretions, can significant inhibit G (-) bacteria, Studies have shown that Lf hydrolyzed by pepsin (LfH) can enhance antibacterial effect. This work attempted to apply Nisin combining LFH

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Pereira, Jessica Filipa Monteiro Martins. "Bacterial Pathogens Survival Strategies – The Haem Biosynthesis Pathway in Campylobacter jejuni." Master's thesis, 2020. http://hdl.handle.net/10362/112886.

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Campylobacter jejuni is one of the most common foodborne pathogens responsible for the majority of the worldwide diarrhoeal infections, causing illness to more than 137 million people every year according with World Health Organization. Despite its widespread and persistence, the essential molecular mechanisms for C. jejuni successful development and infection of the host are still poorly understood. This is the case of haem homeostasis, which is an essential process to bacterial development and plays a very important role during the infection process. Haem is an iron-containing porphyrin that

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30

Higginbotham, Katherine Marie. "The Photorhabdus temperata sspAB locus is required for symbiont transmission in Heterorhabditis bacteriophora." Diss., 2008.

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Thesis (M.S.)--Michigan State University. Dept. of Biochemistry and Molecular Biology, 2008.<br>"Advisor, Todd A. Ciche"--Acknowledgements. Title from PDF t.p. (viewed on Aug. 5, 2009) Includes bibliographical references. Also issued in print.

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Dwivedi, Gajendradhar R. "Structural and Biochemical Analysis of DNA Processing Protein A (DprA) from Helicobacter Pylori." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/3499.

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H. pylori has a panmictic population structure due to high genetic diversity. The homoplasy index for H. pylori is 0.85 (where 0 represents a completely clonal organism and 1.0 indicates a freely recombining organism) which is much higher than homoplasy index for E. coli (0.26) or naturally competent Neisseria meningitides (0.34). It undergoes both inter as well as intra strain transformation. Intergenomic recombination is subject to strain specific restriction in H. pylori. Hence, a high homoplasy index means that competence predominates over restriction in H. pylori. Annotation of the genome

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Dwivedi, Gajendradhar R. "Structural and Biochemical Analysis of DNA Processing Protein A (DprA) from Helicobacter Pylori." Thesis, 2014. http://etd.iisc.ernet.in/2005/3499.

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H. pylori has a panmictic population structure due to high genetic diversity. The homoplasy index for H. pylori is 0.85 (where 0 represents a completely clonal organism and 1.0 indicates a freely recombining organism) which is much higher than homoplasy index for E. coli (0.26) or naturally competent Neisseria meningitides (0.34). It undergoes both inter as well as intra strain transformation. Intergenomic recombination is subject to strain specific restriction in H. pylori. Hence, a high homoplasy index means that competence predominates over restriction in H. pylori. Annotation of the genome

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Um, Nlend Ingrid. "New insights into small molecules inhibitors and protein-protein interactions of VirB8 : a critical conserved component of the type IV secretion system." Thèse, 2015. http://hdl.handle.net/1866/13799.

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