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1

Gabbott, Ian. "Designer granules : beating the trade-off between granule strength and dissolution time." Thesis, University of Sheffield, 2007. http://etheses.whiterose.ac.uk/3605/.

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The work described in this part of the thesis is involved mainly with uprating a 55W air-turbine driven permanent magnet generator to 250W. It is shown that the electrical performance of the generator can be predicted from a simple equivalent circuit comprising an, induced emf source with a series inductance and resistance. When matching the generator and turbine characteristics iron losses are included as an additional torque requirement. Analysis has identified that the most important parameters which determine the rating-of the generator are the stator flux, linkage, stator inductance, and
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2

Kilpatrick, Lynn Agnes. "Biogenesis of chromaffin granules." Thesis, University of Edinburgh, 1985. http://hdl.handle.net/1842/18345.

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Bovine adrenal medullary messenger RNA was isolated and translated in optimised reticulocyte lysate and wheatgerm cell-free translation systems. Reticulocyte lysate was found to be the superior translation system. An attempt was made to characterize the primary polypeptide precursors to the major chromaffin granule secretory protein, chromogranin A, and to the two major chromaffin granule membrane proteins, dopamine β-hydroxylase and cytochrome b561 using previously prepared and well-characterized antisera raised against these proteins. Two similar polypeptides of 70,000 and pI of about 5.2 we
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3

Miller, Linda. "Characterization of ribonucleic acid granules." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:8881/R/?func=dbin-jump-full&object_id=92296.

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Boren, Mats. "Proteomics of barley starch granules /." Uppsala : Dept. of Plantbiology and Forest Genetics, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/2005107.pdf.

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Van, Eeden Alida Elizabeth. "Extracellular polymer extraction and analysis from UASB granules and batch produced anaerobic granular sludge." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/52841.

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Thesis (MSc Food Sc)--Stellenbosch University, 2002.<br>ENGLISH ABSTRACT: The start-up period of Upflow Anaerobic Sludge Bed (UASB) reactors can significantly be reduced by enhancing the time-consuming granulation process through the batch cultivation of anaerobic granular sludge and thus seeding the reactor with this cultivated granular sludge, instead of raw anaerobic sludge. The precise mechanism for granule formation is not well known, but it is believed that extracellular polymers (ECP) play a critical role in the granulation process. Information on the precise role of ECP is also
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Cid, Samper Fernando 1991. "Computational approaches to characterize RNP granules." Doctoral thesis, Universitat Pompeu Fabra, 2020. http://hdl.handle.net/10803/668449.

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Ribonucleoprotein granules (RNP granules) are liquid-liquid phase separated complexes composed mainly by proteins and RNA. They are responsible of many processes involved in RNA regulation. Alterations in the dynamics of these proteinRNA complexes are associated with the appearance of several neurodegenerative disorders such as Amyotrophic Lateral Sclerosis ALS or Fragile X Tremor Ataxia Syndrome FXTAS. Yet, many aspects of their organization as well as the specific roles of the RNA on the formation and function of these complexes are still unknown. In order to study RNP granules structu
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7

Abou, Chakra Oussama. "Allergénicité des Granules Cytoplasmiques de Pollen." Phd thesis, Université Paris-Diderot - Paris VII, 2009. http://pastel.archives-ouvertes.fr/pastel-00567120.

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Le pollen des Graminées est l'un des principaux vecteurs d'allergènes. Il contribue à l'apparition des allergies respiratoires comme l'asthme et la rhinite allergique. En contact avec l'eau de pluie ou des polluants atmosphériques, le pollen peut libérer des microparticules (<5 !m) dites granules cytoplasmiques de pollen. À cause de leur taille, ces granules peuvent pénétrer plus profondément dans l'appareil respiratoire que le pollen entier et induire ainsi des réactions allergiques. L'objectif de ce travail est de caractériser l'allergénicité de ces granules selon 3 volets : épidémiologique,
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8

Mokas, Sophie. "Mécanismes d'assemblage des granules de stress." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/28583/28583.pdf.

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Les granules de stress (GS) sont des sites de régulation de la traduction qui permettent aux cellules cancéreuses de survivre au stress. Elles apparaissent sous différentes conditions de stress et disparaissent une fois remises de celles-ci. Elles se forment selon deux voies, l’une dépendante de la phosphorylation du facteur eIF2α et l’autre indépendante. Les mécanismes d’assemblage des GS par cette dernière voie restent méconnus. Afin de définir ces mécanismes, l’objectif principal de ma maîtrise était de caractériser les étapes critiques de la formation de GS. En utilisant des approches phar
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9

Marmuse, Laurence. "Maltooligosaccharides as models for starch granules." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.410123.

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10

Cheong, Yuen Sin. "Mechanical characteristics of model binderless granules." Thesis, University of Sheffield, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434489.

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11

Horowitz, Daniel Mark. "Biomimetic, amorphous granules of poly(hydroxyalkanoates)." Thesis, University of Cambridge, 1994. https://www.repository.cam.ac.uk/handle/1810/272774.

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12

Abou, Chakra Oussama. "Allergénicité dez Granules Cytoplasmiques de Pollen." Paris 7, 2009. https://pastel.archives-ouvertes.fr/pastel-00567120.

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Le pollen des Graminées est l'un des principaux vecteurs d'allergènes. Il contribue à l'apparition des allergies respiratoires comme l'asthme et la rhinite allergique. En contact avec l'eau de pluie ou des polluants atmosphériques, le pollen peut libérer des microparticules (&lt;5 μm) dites granules cytoplasmiques de pollen. À cause de leur taille, ces granules peuvent pénétrer plus profondément dans l'appareil respiratoire que le pollen entier et induire ainsi des réactions allergiques. L'objectif de ce travail est de caractériser l'allergénicité de ces granules selon 3 volets : épidémiologiq
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13

Myllärinen, Päivi. "Starches : from granules to novel applications /." Espoo [Finland] : Technical Research Centre of Finland, 2002. http://www.vtt.fi/inf/pdf/publications/2002/P473.pdf.

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14

Petoukhov, Eugenia. "Activity-mediated secretion of progranulin-containing granules." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/43133.

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Progranulin (PGRN) is a multi-functional, secreted growth factor expressed in a variety of tissues throughout the body. In the central nervous system (CNS), PGRN is expressed in microglia as well as in a number of neuronal populations and has been shown to promote neuronal survival, enhance neurite outgrowth and regulate inflammation and development. Mutations in the progranulin (GRN) gene have been identified as a major cause of autosomal dominant frontotemporal dementia (FTD) with tau-negative inclusions. The majority of GRN mutations result in the production of a null allele and reduced PG
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15

Lynn, Andrew. "The effect of processing on starch granules." Thesis, Heriot-Watt University, 1992. http://hdl.handle.net/10399/1503.

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16

Brind, Alison Mary. "Alpha-1-antitrypsin granules in the liver." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309067.

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Zhuk, Mikalai. "Nanostructured granules for controlled delivery of dexamethasone." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/14181.

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Mestrado em Ciência e Engenharia de Materiais<br>A Drug Delivery System (DDS) may provide the precise transportation of the medical drug inside the patient’s body, directly to the pathological area or alternatively it may be also locally administrated. Once at the site of interest, the ideal DDS is expected to release the drug in a sustained manner according to the specific needs of the patient. As compared to other routes of drug administration, an appropriately designed DDS which active components are conveniently targeted should also ensure the desired in situ treatment without harmful effe
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18

Al-Sailawi, Majid. "Investigating RNA granules formation during caliciviruses infection." Thesis, University of Surrey, 2015. http://epubs.surrey.ac.uk/809289/.

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Human norovirus (HuNV) is a member of the calicivirus family and is a major cause of viral gastroenteritis worldwide. Due to the absence of a suitable cell culture system, HuNoV replication mechanisms are poorly understood, but two animal caliciviruses, Feline calicivirus (FCV) and Murine Norovirus (MNV) provide models to increase our understanding of norovirus biology. Unlike cellular mRNAs, the calicivirus RNA genome does not possess a 5' cap structure but instead has a 13–15 kDa viral protein, genome linked (VPg) directing translation, hijacking the host protein synthesis machinery. The vir
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19

Piccinini, Marzio. "Porous calcium phosphate granules for biomedical applications." Doctoral thesis, Università degli studi di Trento, 2012. https://hdl.handle.net/11572/368075.

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The repair or replacement of damaged or diseased hard tissue is a biomedical field that has been the subject of more and more interest in many areas of research and especially in the development of new biomaterials. The rise in the average age of the world population, increasing osteoporosis treatments and the spread of cancer and genetic bone diseases, has brought about the need to find solutions for patient care. To achieve this target/objective, biomaterials must simulate the body environment as much as possible and favour tissue repair by integrating them into the host site. Calcium phosp
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20

Piccinini, Marzio. "Porous calcium phosphate granules for biomedical applications." Doctoral thesis, University of Trento, 2012. http://eprints-phd.biblio.unitn.it/794/1/PhD%2BThesis_Piccinini_Definitiva_Aprile%2B2012.pdf.

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The repair or replacement of damaged or diseased hard tissue is a biomedical field that has been the subject of more and more interest in many areas of research and especially in the development of new biomaterials. The rise in the average age of the world population, increasing osteoporosis treatments and the spread of cancer and genetic bone diseases, has brought about the need to find solutions for patient care. To achieve this target/objective, biomaterials must simulate the body environment as much as possible and favour tissue repair by integrating them into the host site. Calcium phos
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21

Jayakody, J. A. Luckshman Priyadharshana. "The effect of acid hydrolysis on granular morphology and physicochemical properties of native cereal starch granules." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ62392.pdf.

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22

Agniel, Yvan. "Rôle des propriétés des granules pour la fabrication de pièces de poudres céramiques granulées sans défaut de compaction." Lyon, INSA, 1992. http://www.theses.fr/1992ISAL0072.

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La granulation d'une poudre fine de céramique permet d'améliorer considérablement ses propriétés de compaction et donc de frittage à condition d'obtenir une destruction totale des granules lors de la mise en forme. Des granules modèles ont pour ce faire été testées de façon unitaire (compression uni axiale) et dans un lit de granules (compaction bilatérale dans une presse instrumentée construite par nos soins). Les résultats ont ensuite été comparés sur la base de modèles de compaction de la littérature scientifique après leur modification, et une corrélation empirique a été trouvée entre les
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23

Perry, Paul Anthony. "Plasticisation and thermal modification of starch." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.340970.

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24

Stewart, James Alexander. "Engineering the properties of spray-dried detergent granules." Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548673.

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25

Griffith, J. D. "The drying and absorption properties of surfactant granules." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599715.

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The work in this thesis contributes to an understanding of the evolution of the drying kinetics and internal microstructure of a model detergent paste (called a crutcher mix) during the spray drying stage in the manufacture of washing powders in order that the physical and cleaning properties of the final dried detergent powder can ultimately be more easily controlled and manipulated. Regularisation algorithms were developed and employed in conjunction with nuclear magnetic resonance (NMR) spectroscopy and relaxometry techniques to characterise both the bulk and individual constituent componen
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26

Pilling, Emma. "The origins of growth ring in starch granules." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365027.

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27

Rinn, Cornelia. "Pancreatic zymogen granules: new proteins in unexpected places." Doctoral thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/7309.

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Doutoramento em Biologia<br>Os mecanismos de biogénese, distribuição apical e secreção regulada de enzimas digestivas dos grânulos de zimogénio são, atualmente, pouco conhecidos. De modo a esclarecer e descrever estes processos de elevada importância biológica e clínica, é necessária uma melhor compreensão dos componentes da membrana granular e as funções e interações destes. Neste trabalho, através de uma abordagem proteómica, foi possível identificar novas proteínas granulares previamente associadas ao transporte vesicular sináptico. Para estudar as funções destas proteínas na génese
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28

Mansour, Rana. "Rôle du Ptdlns5P et de PIKfyve dans le contrôle de l'intégrité des granules plaquettaires." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30089/document.

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Les plaquettes jouent un rôle primordial dans le processus d'hémostase. Elles sont générées à partir des mégacaryocytes (MK) présents dans la moelle osseuse. En plus des compartiments vésiculaires classiques de la voie d'endocytose et de dégradation vers les lysosomes, les plaquettes possèdent deux compartiments sécrétoires additionnels, les granules alpha et denses. Ces granules sont générés au cours de la maturation des MK à partir des corps multivésiculaires (MVB) et contiennent des molécules essentielles aux fonctions plaquettaires. Un défaut dans la production ou le remplissage de ces gra
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Heinze, Karsta. "From grain to granule : the biomechanics of wheat grain fractionation with a focus on the role of starch granules." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTS072/document.

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La culture du blé est l’une des plus importantes au monde. Le grain de blé est un matériau composite naturel dont la majeure partie est constituée d’albumen amylacé formé d’un assemblage compact de granules d’amidons (glucides) enchâssés dans une matrice protéique (gluten). Pour obtenir des produits comme la farine, la structure de l'albumen doit être fragmentée en broyant les grains sous des fortes contraintes. La quantité et la qualité des produits obtenus dépendent du comportement de l’albumen à la fragmentation. En raison de sa nature composite, le comportement rhéologique du grain est tri
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KANEDA, TOSHIO, TAKESHI HOSHINO, MINORU UEDA, HIDEKI MIZUTANI, and MICHIO KAWAI. "Cervicofacial Actinomycosis: Report of Two Cases." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/17537.

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31

Verhoeven, Tamara M. O. "Determination of the morphology of starch granules in cereal endosperm." Thesis, University of East Anglia, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268549.

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32

Pryde, James Grant. "Biogenesis of secretory granules in the bovine adrenal medulla." Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/24238.

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33

Fanous, Alaa. "Elucidating the Functional Role of TDRD3 in Stress Granules." Thèse, Université d'Ottawa / University of Ottawa, 2014. http://hdl.handle.net/10393/31019.

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Tudor domain-containing protein 3, TDRD3, was first identified in a proteomic survey of the spliceosome machinery. Although its function remains elusive, elevated TDRD3 gene expression is associated with poor prognosis of estrogen receptor-negative breast cancer. The Tudor domain of TDRD3 is highly similar to the Tudor domain of the survival of motor neuron (SMN) and accordingly, it has been shown to bind dimethylated arginine residues. Our lab has previously demonstrated the association of TDRD3 with the translation machinery and most importantly, its localization to stress granules (SG) upon
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34

Arden, Catherine. "Compartmentation and function of glucokinase in insulin secretory granules." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.407841.

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35

Maxim, Robert E. "Designing granules for abrasive cleaning (using high-shear granulation)." Thesis, University of Sheffield, 2006. http://etheses.whiterose.ac.uk/14898/.

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This work investigates the granulation of fine calcium carbonate powder to form microgranules (less than lOOf.lll1). The influence offormulation and operating conditions on granule properties was investigated. This work analyses experimental data using a database approach to relate granulation conditions to granule properties, to fmd propertyto-property relationships and to investigate the influence on the abrasion of Perspex. It was found that the granulation was undertaken in an unstable regime dictated by the need to produce small granules. As a result, it was not possible to achieve reprod
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36

Langford, Harry. "The microstructure, biogeochemistry and aggregation of Arctic cryoconite granules." Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/2931/.

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Cryoconite granules are hydrous microaggregates, principally composed of microorganisms, organic matter and mineral particles, that reside upon glacier surfaces. Whilst recent research has highlighted the diverse microbial community within cryoconite granules and their role as biogeochemical reactors, little is known about their microstructure, the cell–mineral interaction within them, or their aggregation mechanisms. Knowledge of these is crucial for the understanding of autotrophic organic matter production and cycling, the entrainment of particulate matter and its consequential effect on gl
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37

Riemschoß, Katrin [Verfasser]. "Similarities of stress granules and cytosolic prions / Katrin Riemschoß." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/1206246170/34.

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38

Formicola, Nadia. "Remodelage des granules ARN en réponse à l’activité neuronale." Electronic Thesis or Diss., Université Côte d'Azur (ComUE), 2019. http://theses.univ-cotedazur.fr/2019AZUR6008.

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Une des questions les plus fascinantes – et les plus ouvertes – en neuroscience est de comprendre comment les cellules neuronales contribuent à la formation, le maintien puis le rappel des souvenirs. Des travaux antérieurs ont montré que la formation de la mémoire à long-terme (MLT) requiert la synthèse de novo de protéines, impliquant non seulement la traduction d’ARNs nouvellement transcrits, mais aussi la traduction locale, induite par l’expérience, d’ARNms latents transportés et stockés dans les synapses. En vue de leur transport et du contrôle de leur traduction, les ARNms sont empaquetés
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Ikeda, Noboru. "Quantitative comparison of osteoconduction of porous, dense A-W glass-ceramic and hydroxyapatite granules (effects of granule and pore size)." Kyoto University, 2000. http://hdl.handle.net/2433/180891.

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40

Tahir, Muhammad Javaid. "Isolation and characterization of dense granules of Eimeria tenella sporozoites." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ35939.pdf.

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41

Lauzier, Christian. "Morphology and crystallization behavior of nascent poly(3-hydroxybutyrate) granules." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41136.

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The structure of poly(3-hydroxybutyrate) (PHB) granules was examined by transmission and scanning electron microscopy (TEM and SEM). They are made of two distinct components: a solid shell (overlapping lamellar crystals) and a non-crystalline core.<br>TEM examination of sections of PHB granules revealed that, upon annealing, the core molecules transform into stacks of lamellar crystals of $ sim$50-70A in thickness. Fourier transform infrared results revealed the presence of bound water in a sample of freeze dried granules. Solid state $ sp{13}$C NMR results showed that the mobility of the gran
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42

Boutell, Suzanne Louise. "Factors influencing the preparation of spherical granules by extrusion/spheronisation." Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.481206.

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43

Chapman, Stephen Robert. "Influence of process variables on the preparation of spherical granules." Thesis, King's College London (University of London), 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282983.

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44

Gasparinho, Goncalves A. C. "Understanding the role of stress granules in the inner ear." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1553331/.

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The human ear undergoes stress constantly. Exposure to noise, drugs or ageing contribute to the irreversible loss of hair cells, resulting in hearing loss. To understand why we go deaf, it is important to understand how the ear responds to stress. Stress granules (SGs) are aggregates of mRNA and proteins that are formed during stress. The SG-pathway has been implicated in the cochlea’s response to aminoglycoside antibiotics, suggesting that SGs play an important role during ototoxicity. Dysregulation of SG-formation has also been linked to neurodegeneration, supporting the hypothesis that SGs
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45

Острога, Руслан Олексійович, Руслан Алексеевич Острога, Ruslan Oleksiiovych Ostroha, and S. P. Shevets. "The mineral fertilizer granules encapsulating in a multistage shelf apparatus." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/52135.

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Currently the production and rational use of fertilizers is extremely important for agriculture, and before science there is a task to develop environmental friendly technologies of manufacturing and use of fertilizers. Nitrogen fertilizers (ammonium nitrate, urea) and phosphorus ones (superphosphate, ammophos) dominate in the range of mineral fertilizers used in all edaphic-climatic zones all over the world. They are transformed in the system soil - plant and provide the needs of growing plants in nutrient components. But along with the well-known advantages these fertilizers have significant
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46

Albaraki, Saeed Mohammed A. "Micromechanical analysis of pharmaceutical granules using advanced experimental imaging methodologies." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/12207/.

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Fundamental level understandings on the processing behaviours of materials in granular and powder form is of high interest to number of engineering industries for example, mining, mineral, pharmaceutical, geotechnical and for advanced material processing applications. Handling and processing of pharmaceutical powders through confined geometries have very important role in pharmaceutical industry and many related powder process engineering sectors. Smooth flow of powders and granules mixtures from the feeding hopper to the compression chamber plays a very crucial role to achieve the integrity a
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47

Muckley, Philippa L. "A study of RAB3 GTP-binding proteins in the secretory pathways of a mouse pituitary cell line." Thesis, Oxford Brookes University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287728.

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48

Franco, Daiane Gil. "Modulação da produção de óxido nítrico por melatonina em cultura de células de cerebelo." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-25082010-110730/.

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A melatonina, um derivado da serotonina, é o principal produto da glândula pineal. Pode ser produzida também por diversas células e tecidos extrapineais, como retina, trato gastrointestinal, células do sistema imunológico, entre outros. Nos mamíferos exerce diferentes papéis, sendo que, classicamente, é conhecida por atuar como mediadora química da fase escura. A liberação rítmica desse hormônio para a corrente sanguínea e para o líquido cefalorraquidiano marca o ciclo claro-escuro e as estações do ano para os órgãos internos. Além disso, a melatonina atua como moduladora do sistema imunológic
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Vijayakumar, Jeshlee Cyril. "Rôle du domaine de type prion de Imp dans la régulation des granules RNP neuronaux." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4099/document.

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Les ARNms des cellules eucaryotes sont liés à des protéines de liaison aux ARNs (RBPs) et empaquetés au sein d’assemblages macro-moléculaires appelés granules RNP. Dans les cellules neuronales, les granules RNP de transport sont impliqués dans le transport d’ARNms spécifiques jusqu’aux axones et dendrites, ainsi que dans leur traduction locale en réponse à des signaux externes. Bien que peu de choses soient connues sur l’assemblage et la régulation de ces granules in vivo, des résultats récents ont indiqué que la présence de domaines de type prion (PLDs) dans les RBPs facilite les interactions
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Fung, Gabriel. "Interplay between stress granules, cellular stress response, and coxsackievirus B3 infection." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58510.

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Viral infection affects a multitude of cellular processes to facilitate successful replication. Such responses include the formation of stress granules (SGs) and the activation of autophagy. SGs are stalled translational complexes and function to restore cellular homeostasis after stress. Autophagy is a cellular process that recycles misfolded proteins and damaged organelles and plays an important role in various stress responses. We previously demonstrated that infection with Coxsackievirus B3 (CVB3), a common human pathogen for viral myocarditis, disrupts the autophagic process to support ef
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