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Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Deng, Yifu. "Case-only study of interactions between specific genetic polymorphisms and cigarette smoking in the aetiology of Parkinson's disease." Queensland University of Technology, 2005. http://eprints.qut.edu.au/16211/.

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The aetiology of Parkinson's disease (PD) is still unclear. Research findings suggest that both environmental and genetic factors may contribute to its development. The interactions between genes and the environment might exist and play a key role. Cigarette smoking was found to be one of the few factors exhibiting a protective effect. If chemical compounds found in cigarette smoke influence PD risk, the difference in the ability of certain individuals in metabolising these substances might alter their susceptibility to the risk of developing PD. Many metabolic enzyme genes exhibit polymorphic

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Deng, Yifu. "Case-only study of interactions between specific genetic polymorphisms and cigarette smoking in the aetiology of Parkinson's disease." Thesis, Queensland University of Technology, 2005. https://eprints.qut.edu.au/16211/1/Yifu_Deng_Thesis.pdf.

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The aetiology of Parkinson's disease (PD) is still unclear. Research findings suggest that both environmental and genetic factors may contribute to its development. The interactions between genes and the environment might exist and play a key role. Cigarette smoking was found to be one of the few factors exhibiting a protective effect. If chemical compounds found in cigarette smoke influence PD risk, the difference in the ability of certain individuals in metabolising these substances might alter their susceptibility to the risk of developing PD. Many metabolic enzyme genes exhibit polymorphic

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Honma, Helen Naemi 1971. "Influencia dos polimorfismos nos genes CYP1A1*2A, GSTM1, GSTT1 e GSTP1*B na susceptibilidade ao cancer de pulmão." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310260.

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Orientadores: Lair Zambon, Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-09T12:57:06Z (GMT). No. of bitstreams: 1 Honma_HelenNaemi_M.pdf: 6073042 bytes, checksum: 8de4d548610b680b2101397d10fc9e52 (MD5) Previous issue date: 2007<br>Resumo: A citocromo P- 450 1A1 (CYP1A1) é uma importante enzima do metabolismo carcinogênico, em virtude da regulação polimórfica, a CYP1A1 é um marcador genético promissor para susceptibilidade de certas malignidades, particularmente o câncer de pulmão (

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Lima, Brena de Lourdes Aguiar. "Caracterização molecular das enzimas glutationa stransferase (genes gstt1, gstm1 e gstp1) em pacientes com malária por plasmodium vivax." Universidade Federal do Amazonas, 2013. http://tede.ufam.edu.br/handle/tede/2576.

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Made available in DSpace on 2015-04-11T13:54:30Z (GMT). No. of bitstreams: 1 Brena de Lourdes Aguiar Lima.pdf: 1248497 bytes, checksum: d14922a8c86943653012f0ea3e3818cf (MD5) Previous issue date: 2013-04-08<br>CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Plasmodium vivax threatens ~40% of the world s population, with a wide spectrum of asymptomatic to severe clinical manifestations. Glutathione S-transferase (GST) gene polymorphisms have been shown to influence their ability to reduce oxidative stress. Using molecular tools we identified and compared GSTM1, GSTT1

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Ozcelik, Aysun. "Association Of The Cyp2e1, Fmo3, Nqo1, Gst And Nos3 Genetic Polymorphisms With Ischemic Stroke Risk In Turkish Population." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613933/index.pdf.

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Stroke, a major cause of death and disability, is described as interruption or severe reduction of blood flow in cerebral arteries. Oxidative stress plays an important role in the pathogenesis of atherosclerosis and carotid atherosclerosis is a risk factor for stroke. Combination of multiple environmental and genetic risk factors is thought to increase susceptibility to the development of this disease. Therefore, investigation of the polymorphisms of drug metabolizing enzymes is of crucial importance to determine the molecular etiology of the disease. The main objective of this study was to in

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Lopes, Ana Karolina. "ESTUDO DE POLIMORFISMOS NOS GENES GSTT1 E GSTM1 E SUAS ASSOCIAÇÕES AO TABAGISMO E AO CÂNCER DE CAVIDADE ORAL." Pontifícia Universidade Católica de Goiás, 2016. http://localhost:8080/tede/handle/tede/3035.

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Made available in DSpace on 2016-08-10T10:55:03Z (GMT). No. of bitstreams: 1 ANA KAROLINA LOPES.pdf: 9734532 bytes, checksum: 4203439893759543f5fa8773dd844696 (MD5) Previous issue date: 2016-03-11<br>The oral cancer is considered a public health problem worldwide. Are estimated for the biennium 2016-2017, in Brazil, 15,490 new cases of this disease that is the result of interactions between genetic and environmental factors, therefore, considered to be multifactorial. Genes related to the carcinogen detoxification process can influence the risk of developing cancer of the oral cavity. The ob

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Cardoso, Filho Cassio 1974. "Influencia dos polimorfismos dosalelos Mu 1 (GSTM1) e Theta 1 (GSTT1) do sistema da glutatina S-transferase na susceptibilidade ao cander de mama esporadico." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311115.

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Orientador: Maria Salete Costa Gurgel<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-09T01:46:42Z (GMT). No. of bitstreams: 1 CardosoFilho_Cassio_M.pdf: 1571004 bytes, checksum: 252da74a9dd5114a82f05ed36b7face1 (MD5) Previous issue date: 2007<br>Resumo: Introdução: As deleções dos genes GSTM1 e GSTT1 têm sido associadas ao aumento do risco de várias neoplasias, porém não há consenso sobre suas influências no câncer de mama. Objetivo: Avaliar a ocorrência das deleções homozigóticas dos GSTM1 e GSTT1 em mulher

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Piqué, Benages Maria Esther. "Estudi dels polimorfismes genètics de les glutatió S-transferases (GSTM1, GSTM3, GSTT1 i GSTP1) i de l'epòxid hidrolasa microsomal (EPHX1) com a factors moduladors dels efectes carcinogènics." Doctoral thesis, Universitat de Barcelona, 2002. http://hdl.handle.net/10803/673101.

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La majoria dels processos cancerígens són esporàdics (adquirits), és a dir que no estan relacionats amb l’herència, i solen estar causats per l'exposició a agents carcinògens.. Tant el càncer de pulmó com el de laringe en són un exemple en l'etiologia d'aquests dos tipus de càncer destaca el fum del tabac com a principal factor involucrat en el desenvolupament del càncer de pulmó í com un factor molt important en el de laringe. El fum del tabac és una barreja complexa, en la que hi ha identificats aproximadament de 4.000 a 6.000 compostos diferents (IARC, 1986). Entre ells es tro

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Carvalho, Wanessa Fernandes. "AVALIAÇÃO DE DANOS GENÉTICOS E CORRELAÇÃO COM POLIMORFISMOS NOS GENES GSTM1 E GSTT1 EM TRABALHADORES OCUPACIONALMENTE EXPOSTOS A AGROTÓXICOS EM MUNICÍPIOS GOIANOS COM INTENSA ATIVIDADE AGRÍCOLA." Pontifícia Universidade Católica de Goiás, 2014. http://localhost:8080/tede/handle/tede/2381.

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Made available in DSpace on 2016-08-10T10:38:50Z (GMT). No. of bitstreams: 1 Wanessa Fernandes Carvalho.pdf: 6063093 bytes, checksum: 0ea1cba23ab3d2a3ae295a8c03e44030 (MD5) Previous issue date: 2014-02-10<br>Os agrotóxicos tem sido alvo de preocupação por parte dos diversos segmentos da sociedade, uma vez que o uso indiscriminado (regido por fatores, como: uso inadequado, alta toxicidade, falta do uso de equipamentos de proteção e precariedade dos mecanismos de vigilância) podem gerar impactos ambientais, sociais e sanitários. A exposição ocupacional de trabalhadores agrícolas ocorre por fal

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Paz, Silvana Sousa da. "Avaliação de marcadores genéticos associados a detoxificação de xenobióticos e ao estresse oxidativo na evolução de pacientes com leucemia linfóide aguda da infância no estado da Bahia-Brasil." reponame:Repositório Institucional da FIOCRUZ, 2012. https://www.arca.fiocruz.br/handle/icict/4304.

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Submitted by Ana Maria Fiscina Sampaio (fiscina@bahia.fiocruz.br) on 2012-08-29T21:11:40Z No. of bitstreams: 1 Silvana Sousa Paz Avaliação de marcadores....pdf: 756990 bytes, checksum: 5aac886be232eac44d86b25a30837ac4 (MD5)<br>Made available in DSpace on 2012-08-29T21:11:40Z (GMT). No. of bitstreams: 1 Silvana Sousa Paz Avaliação de marcadores....pdf: 756990 bytes, checksum: 5aac886be232eac44d86b25a30837ac4 (MD5) Previous issue date: 2012<br>Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil<br>As leucemias são malignidades hematopoiéticas, caracterizadas p

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Godoy, Fernanda Ribeiro. "ANÁLISE MOLECULAR DOS POLIMORFISMOS DOS GENES GSTM1 E GSTT1 EM INDIVÍDUOS OCUPACIONALMENTE EXPOSTOS A AGROTOXICOS." Pontifícia Universidade Católica de Goiás, 2013. http://localhost:8080/tede/handle/tede/2372.

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Made available in DSpace on 2016-08-10T10:38:46Z (GMT). No. of bitstreams: 1 FERNANDA RIBEIRO GODOY.pdf: 1338419 bytes, checksum: 9ce2f93850f1257da6253ceadf307402 (MD5) Previous issue date: 2013-02-15<br>The impact of pesticide on agricultural workers is an issue that has received attention from the scientific community worldwide. Occupational exposure of agricultural workers occurs due to lack of information or lack of skilled technical resources. These workers are exposed to pesticides in crops and this exposure may be responsible for genetic damage causing a health issue. A problem with t

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Lima, Rayane Mendes de. "O papel do polimorfismo metabólico de GSTM1 e GSTT1 na susceptibilidade a nefropatia diabética." Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/5723.

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Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-07-13T20:37:59Z No. of bitstreams: 2 Dissertação - Rayane Mendes de Lima - 2016.pdf: 1517541 bytes, checksum: 21e56d88c3ecbe596bbba9be9f3ea87e (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2016-07-14T13:04:34Z (GMT) No. of bitstreams: 2 Dissertação - Rayane Mendes de Lima - 2016.pdf: 1517541 bytes, checksum: 21e56d88c3ecbe596bbba9be9f3ea87e (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made

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Pinheiro, Denise da Silva. "Avaliação do polimorfismo de deleção de GSTT1 e GSTM1 na susceptibilidade ao diabetes mellitus tipo 2." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3482.

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Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2014-10-30T18:14:19Z No. of bitstreams: 2 Dissertação - Denise da Silva Pinheiro.pdf: 1388647 bytes, checksum: e26020f5d13976c2a4920327b71bc5c4 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2014-10-31T09:40:46Z (GMT) No. of bitstreams: 2 Dissertação - Denise da Silva Pinheiro.pdf: 1388647 bytes, checksum: e26020f5d13976c2a4920327b71bc5c4 (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Made

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Batista, Mariana Pedrosa. "Avaliação citogenética e molecular de indivíduos ocupacionalmente expostos aos agrotóxicos." Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tde/3014.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2014-09-04T19:33:18Z No. of bitstreams: 2 Batista, Mariana Pedrosa - Avaliação citogenética e molecular de indivíduos ocupacionalmente expostos aos agrotóxicos - 2014.pdf: 1556018 bytes, checksum: 89fbad76ace350a8cf9c7db5c92f015d (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Made available in DSpace on 2014-09-04T19:33:18Z (GMT). No. of bitstreams: 2 Batista, Mariana Pedrosa - Avaliação citogenética e molecular de indivíduos ocupacionalmente expostos aos agrotóxicos - 2014.pdf: 1556018 bytes, che

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Graça, Carla Renata. "Estudos dos polimorfismos dos genes GSTT1, GSTM1 e NINJURIN1 em indivíduos com Hanseníase." Faculdade de Medicina de São José do Rio Preto, 2011. http://bdtd.famerp.br/handle/tede/100.

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Made available in DSpace on 2016-01-26T12:51:29Z (GMT). No. of bitstreams: 1 carlarenatagraca_dissert.pdf: 933158 bytes, checksum: fdfd445f7f2238bec496e0064ddfd5bc (MD5) Previous issue date: 2011-07-26<br>Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae), an obligate intracellular acid-fast bacillus, which affects the skin and peripheral nervous system. The diseases expression results from the interaction between the bacillus and the immune system; most infected subjects develop effective immune response against M. leprae, without disease; others exhibit a sp

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Sarhanis, P. "Epithelial ovarian cancer : influence of polymorphism at the glutathione - s - transferase GSTM1 and GSTT1 loci on expression of P53." Thesis, Keele University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359971.

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Rinck, Júnior José Augusto 1974. "Influência dos polimorfismos dos genes Mu 1 (GSTM1), Theta 1 (GSTT1), XPD Asp312Asn e XPD Lys751Gln na susceptibilidade ao melanoma cutâneo." [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308608.

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Orientador: Carmen Silvia Passos Lima<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-26T16:24:35Z (GMT). No. of bitstreams: 1 RinckJunior_JoseAugusto_D.pdf: 4925898 bytes, checksum: cf6e78a6e4ad84c7bbe48d34d75fdae6 (MD5) Previous issue date: 2015<br>Resumo: As glutationa S-transferases (GSTs) são enzimas detoxificantes. Os genes GSTM1 e GSTT1 são polimórficos e quando deletados perdem a expressão enzimática. As proteínas codificadas pelos genes XPD são responsáveis pelo reparo de lesões do DNA causadas pela luz so

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Palodetto, Bruna 1987. "Influência dos polimorfismos CYP2B6 G15631T, GSTM1, GSTT1, NQO1 C609T e MDR-1 C3435T na resposta ao tratamento de leucemia aguda e síndrome mielodisplásica." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311964.

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Orientador: Sara Teresinha Olalla Saad<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T16:46:11Z (GMT). No. of bitstreams: 1 Palodetto_Bruna_M.pdf: 1523635 bytes, checksum: 0dc5f0194b2dd973ee8eaeac9a384983 (MD5) Previous issue date: 2012<br>Resumo: As síndromes mielodisplásicas (SMD) são um grupo heterogêneo de doenças hematopoiéticas caracterizadas pela hematopoiese ineficaz resultando em citopenia no sangue periférico; cerca de 30% das SMDs evolui para leucemia mielóide aguda secundária. Leucemias agudas

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Silva, Kleber Santiago Freitas e. "POLIMORFISMOS GENÉTICOS EM PACIENTES DE GOIÂNIA COM ENDOMETRIOSE: UM ESTUDO ANALÍTICO." Pontifícia Universidade Católica de Goiás, 2013. http://localhost:8080/tede/handle/tede/2366.

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Made available in DSpace on 2016-08-10T10:38:42Z (GMT). No. of bitstreams: 1 KLEBER SANTIAGO FREITAS E SILVA.pdf: 1080005 bytes, checksum: 9dfcb821b9cd1574718e2442cabc533b (MD5) Previous issue date: 2013-02-18<br>In healthy women, a great number of intra and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. In endometriosis, abnormalities in those controls can lead to the survival of endometrial cells and consequently their attachment to the peritoneal cavity and disease progression. Endometrial cells with genetic polymorphisms respond to local sig

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Silva, Erica Furquim Soledade Neves. "Polimorfismos dos genes GSTM1 e GSTT1, do sistema da Glutationa S-Transferase, e T6235C e A4889G do gene CYP1A1, do sistema do Citocromo P450, na susceptibilidade ao carcinoma de celulas escamosas de cabeça e pescoço." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/290505.

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Orientador: Carmen Silvia Passos Lima<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-10T01:04:22Z (GMT). No. of bitstreams: 1 Silva_EricaFurquimSoledadeNeves_M.pdf: 1247474 bytes, checksum: fb164930ca8036640d7d8a9b9f56bca8 (MD5) Previous issue date: 2007<br>Resumo: As glutationa S-transferases (GSTs) são enzimas detoxificantes que atuam no mecanismo de proteção contra a carcinogênese. Os genes GSTM1 e o GSTT1 são polimórficos em humanos e estão deletados de forma homozigótica em 40-50% e 15-25% dos

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Bruhn, Claudia. "Untersuchungen zum genetischen Polymorphismus der humanen Biotransformationsenzyme Glutathion-S-Transferase T1-1 und Arylamin-N-Acetyltransferase 1." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2001. http://dx.doi.org/10.18452/14582.

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Die genetischen Polymorphismen der humanen Biotransformationsenzyme Glutathion-S-Transferase Theta 1 (GSTT1-1) und Arylamin-N-Acetyltransferase 1 (NAT1) wurden zu Beginn der neunziger Jahre entdeckt. Es besteht derzeit ein großes Interesse an Untersuchungen zur Häufigkeit der Allele, zu deren phänotypischen Konsequenzen und pharmakologisch-toxikologischer Relevanz. Für die Untersuchungen in dieser Arbeit standen die Blutproben von 314 gesunden, deutschen Probanden mit bekanntem GSTT1- und/oder NAT1-Genotyp zur Verfügung. Es wurden Methoden etabliert und validiert, um im Hämolysat die Reaktio

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Martins, José Vitor Magalhaes. "ANÁLISE MOLECULAR DO POLIMORFISMO GSTT1 EM PACIENTES COM ATEROSCLEROSE DE GOIÂNIA, GOIÁS." Pontifícia Universidade Católica de Goiás, 2016. http://localhost:8080/tede/handle/tede/2406.

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Made available in DSpace on 2016-08-10T10:39:13Z (GMT). No. of bitstreams: 1 JOSE VITOR MAGALHAES MARTINS.pdf: 1473215 bytes, checksum: f10c80d868f20012e5a78c63010ee3c0 (MD5) Previous issue date: 2016-03-09<br>Atherosclerosis is a chronic inflammatory disease that occurs by the accumulation of lipids in the innermost layer of the artery (intima) of medium and large caliber, this deposit with platelet factors stimulate the proliferation of muscle cells in this region. More than 400 genes may be involved in this pathology, being related to the regulation of endothelial function, coagulation, i

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Reis, Guilherme Miranda dos. "ANÁLISE DO POLIMORFISMO DO GENE GSTT1 EM AMOSTRAS DE PTERÍGIO DE PACIENTES DE GOIÂNIA - GOIÁS - BRASIL." Pontifícia Universidade Católica de Goiás, 2014. http://localhost:8080/tede/handle/tede/2376.

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Made available in DSpace on 2016-08-10T10:38:48Z (GMT). No. of bitstreams: 1 GUILHERME MIRANDA DOS REIS.pdf: 703118 bytes, checksum: a57b9d3ddcbdd975098638c9c7cc6301 (MD5) Previous issue date: 2014-06-09<br>Pterygium is an inflammatory and degenerative ocular surface disease in which the conjunctiva on the cornea grows forming a fibrous tissue in the shape of a triangle. The disorder may be characterized by cell proliferation, inflammatory processes, fibrosis, angiogenesis and destruction of the extracellular matrix. It is erroneously confused the cataract, and the anomaly is considered as a

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Ribeiro, Junior Anicezio de Paula. "ANÁLISE DOS POLIMORFISMOS DO GENE GSTM1 EM AMOSTRAS DE PTERÍGIO EM GOIÂNIA-GOIÁS." Pontifícia Universidade Católica de Goiás, 2014. http://localhost:8080/tede/handle/tede/2378.

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Made available in DSpace on 2016-08-10T10:38:49Z (GMT). No. of bitstreams: 1 ANICEZIO DE PAULA RIBEIRO JUNIOR.pdf: 2091897 bytes, checksum: eeef0e9bac88a2e48f8d2f33adf5d0d2 (MD5) Previous issue date: 2014-06-18<br>The first reports about pterygium date back to Hippocrates. This disease still hides mysteries about its pathogenesis in a way that even today it threaten vision health of many people around the world. It is a formation of fibrous tissue that grows excessively and with an abnormal shape on the cornea The anomaly consists of epithelial and subepithelial tissue and it is highly vascu

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Rodrigues, Débora Acyole. "ANÁLISE DO POLIMORFISMO DO GENE GSTM1 EM PACIENTES COM ATEROSCLEROSE." Pontifícia Universidade Católica de Goiás, 2016. http://localhost:8080/tede/handle/tede/2405.

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Made available in DSpace on 2016-08-10T10:39:13Z (GMT). No. of bitstreams: 1 DEBORA ACYOLE RODRIGUES.pdf: 801098 bytes, checksum: 7abd0f2705d08eea1c26889a71347e27 (MD5) Previous issue date: 2016-03-11<br>The word Atherosclerosis comes from the Greek words athero that means gruel or paste and sclerosis that means hardness. The disease is characterized by lesions in the inner layer of the blood vessels called atheroma or atheromatous plaques. Those plaques block the vascular lumen and weaken the underlying tunica media. Several risk factors for the development of atherosclerosis have been desc

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Hemmingsen, Anja. "The expression and functional significance of glutiathione S-transferase P1 (GSTP1) polymorphism in the lung." Thesis, Keele University, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288498.

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Ulusoy, Gulen. "Association Of Cyp2e1, Nqo1 And Gst Genetic Polymorphisms With Risk Of Acute Lymphoblastic Leukemia In Turkish Children." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12610470/index.pdf.

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Acute lymphoblastic leukemia (ALL) is the most common type of cancer affecting children in the world and in our country. The exact molecular etiology of the disease still remains to be elucidated. This study hypothesized that four genes, namely CYP2E1*5B, *6, and *7B, NQO1*2 SNPs, GSTM1 null and GSTT1 null, alone or in combination, could contribute to the risk of development of childhood ALL. Also interactions of these polymorphisms with non-genetic risk factors were investigated. The genotyping of these polymorphisms were done on 209 healthy subjects, and 185 patients with childhood ALL, in

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Doucette, Kimberley. "The effect of organic solvents and CYP1A1, CYP2E1, GSTM1 polymorphisms on the development of acute lymphoblastic leukemia in Quebec children." Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=106382.

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Background: Childhood acute lymphoblastic leukemia (ALL) is a complex disease whose etiology remains largely unknown. Both genetic and environmental factors are believed to be involved in leukemogenesis. It has long been suspected that organic solvents are carcinogens. They are common in the workplace and are potentially important sources of exposure in mothers during various time periods: preconception, pregnancy and postnatal. These time windows are vital for the developing fetus and exposures to carcinogens through the placenta or breast milk could lead to DNA damage. In addition, variants

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Mo, LingZhao. "Carcinogenèse du col utérin et de l'œsophage : intérêt de l'étude des papillomavirus humains et du polymorphisme de GSTM1 et CYP2E1." Besançon, 2007. http://www.theses.fr/2007BESA0009.

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Le cancer du col de l'utérus est le second cancer féminin au monde et c'est le plus fréquent dans les pays en voie de développement dans lesquels 80% des cas sont identifiés. Des preuves épidémiologiques incontestables indiquent que les papillomavirus humains à haut risque (HPV HR) sont les agents étiologiques des lésions précancéreuses et cancéreuses du col de l'utérus. Dès la fin des années quatre vingt, le développement d'outils de biologie moléculaire a permis d'étudier ces virus et de les détecter dans les frottis cervico-utérins. Dans le cadre du dépistage, la détection des HPV à haut ri

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Lima, Junior Mario Maciel de 1974. "Avaliação antropométrica, prostatica e polimorfismos de TP53 e GSTP1 em populações do estremo setentrional amazônico." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310299.

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Orientadores: Laura Sterian Ward, Ubirajara Ferreira<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T18:25:14Z (GMT). No. of bitstreams: 1 LimaJunior_MarioMacielde_D.pdf: 2397268 bytes, checksum: 63d55e4a5572d5d7f06e615be4d98384 (MD5) Previous issue date: 2012<br>Resumo: As doenças da glândula prostática em geral e a incidência de câncer da próstata, em particular, mostram disparidades acentuadas entre os diferentes países e etnias. De fato, etnia, idade e história familiar são os mais fortes fatores de risco co

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Nava, Tiago Rodrigues. "Modelo de personalização de dose de bussulfano intravenoso baseado no genótipo de GSTA1 durante regime de condicionamento do transplante de células-tronco hematopoiéticas em crianças." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2017. http://hdl.handle.net/10183/169580.

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O bussulfano (Bu) é um agente alquilante usado no condicionamento que precede o transplante de células-tronco hematopoiéticas (TCTH) em crianças. Sua farmacocinética (FC) apresenta uma grande variabilidade interindivíduo, que pode ser parcialmente explicada pelas variantes genéticas de GSTA1, gene da enzima glutationa S-transferase α1, crucial para o metabolismo do Bu. Vários métodos de predição da FC do Bu são usados para calcular sua dose, essencialmente com base na idade e peso do paciente. Até o momento, apenas um modelo adulto incorporou as variantes de GSTA1 no cálculo da sua dose do Bu.

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Chia-Chun and 高嘉君. "Influence of glutathione s-transferase theta (GSTT1) and mu (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/50145295436307966167.

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博士<br>中山醫學大學<br>醫學研究所<br>98<br>Hepatocellular carcinoma (HCC) is one of the most frequent malignant neoplasms worldwide and is the second leading cause of cancer death in Taiwan. Genetic polymorphism has been reported as a factor for increased susceptibility of hepatocellular carcinoma. Glutathione S-transferases theta (GSTT1) and mu (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-related cancer. The aim of this study was to estimate the relationships between these two gene polymorphisms and hepatocellular carcinoma risk and c

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Chen, Chih-Mei, and 陳志玫. "CYP2E1,GSTM1,GSTT1 polymorphism:susceptibility to ethnic and disease.Topic 1:Ethnic variation in CYP2E1,GSTM1,GSTT1 genes polymorphism analysis:Taiwan aborigines,Thai and Philippines." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/07729215143797590453.

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碩士<br>高雄醫學院<br>公共衛生學研究所<br>86<br>TOPIC 1:ethnic variation in CYP2E1,GSTM1,GSTT1 genes polymorphism analysis:Taiwan aborigines, Tahi and Philippines. The individual metabolize the chemical substrates or drugs with different the susceptibility, especially for people who originate from different ethnic groups.Several studies showed that the different susceptibility was determined by genetic polymorphism of three genes-CYP2E1,GSTM1 and GSTT1 have been linked to the susceptibility of some cancer

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Kang, Hsin-Wen, and 康馨文. "Joint effect on risk of urothelial carcinoma between cigarette smoking and genetic polymorphisms of CYP2E1、GSTA1 and GSTP1." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/76279648387740620787.

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碩士<br>臺北醫學大學<br>公共衛生學研究所<br>96<br>Background: Urothelial carcinoma (UC) mostly occurs in the bladder and its major risk factor is cigarette smoking. Although cigarette smoking is considered a major risk factor for bladder carcinoma, little is known about the interaction between metabolic genes such as Cytochrome P450 2E1、glutathione-S-transferase A1 (GSTA1), glutathione-S-transferase P1 (GSTP1) and tobacco smoking in this process. CYP2E1,GSTA1andGSTP1 catalyze the activation of some environmental procarcinogens present in tobacco smoke (i.e. nitrosoamines and heterocyclic amines). We conducted

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Dynybil, Christian Welte Karl. "Untersuchungen zur Assoziation des inaktivierenden NQO1 C609T-Polymorphismus und der GSTM1- und GSTT1-Deletionspolymorphismen mit dem Auftreten sekundärer maligner Neoplasien nach Therapie kindlicher akuter lymphoblastischer Leukämie /." 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014710324&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Cahill, Leah Elizabeth. "Genetic Determinants of Serum Ascorbic Acid Concentrations." Thesis, 2010. http://hdl.handle.net/1807/26134.

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Background: The adequacy of serum ascorbic acid (vitamin C) concentrations in young Canadian adults is unknown. Individuals have varied serum ascorbic acid response to dietary vitamin C, possibly due to genetic variation. Objective: To investigate the prevalence of serum ascorbic acid deficiency in young Canadians and to determine whether common genotypes modify the association between dietary vitamin C and serum ascorbic acid. Methods: Subjects were 1277 men and women aged 20-29 years from the Toronto Nutrigenomics and Health study. Vitamin C intakes were estimated by a 196-item FFQ. Fasting

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Chiang, Pei-Ling, and 江佩陵. "MnSOD, Catalase, UCP2, hOGG1, COMT and GSTM1 Polymorphisms in Endometriosis." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/61123701230463807660.

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碩士<br>臺北醫學大學<br>醫學技術學系<br>94<br>Endometriosis is characterized by the implantation and growth of endometrial tissue outside the uterine cavity. The aetiological factor of endometriosis is still remain poorly understood. Somatic genetic alterations have been found in endometriotic lesions and these may contribute to initiation and progression of endometriosis. Approximately 85～90% of reactive oxygen species (ROS) generation was proposed during the mitochondrial electron transport chain. The intramitochondrial antioxidant enzymes play the pivotal role on the maintenance of mitochondrial genome i

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Resende, Elisabete Cristina Peres. "IL4R, IL13, IL17A, and GSTP1 polymorphims and susceptibility to asthma and rhinitis." Master's thesis, 2016. http://hdl.handle.net/10316/41401.

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Dissertação de mestrado em Investigação Biomédica (Infeção e Imunidade), apresentada à Faculdade de Medicina da Universidade de Coimbra<br>BACKGROUND: Asthma and rhinitis have a complex etiology, depending on multiple genetic and environmental risk factors. An increasing number of susceptibility genes are currently being identified, but the majority of reported associations have not been consistently replicated across populations of different genetic backgrounds. AIMS: To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) and GSTP1 (rs1695) genes are associa

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Siede, Anja. "Polymorphismen der Glutathion-S-Transferase A1 in Zusammenhang mit malignen hämatologischen Erkrankungen." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-AFC9-D.

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Chung, Chi-Jung, and 鍾季容. "Polymorphisms of AS3MT, PNP, GSTO1 and GSTO2, Urinary 8-OHdG, Plasma Vitamins, Polymorphisms of p53, p21 and CCND1, Arsenic Metabolism Capability and Urothelial Carcinoma." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/81859541116287614659.

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博士<br>臺北醫學大學<br>公共衛生學研究所<br>97<br>Epidemiological studies have reported a dose–response relationship between long-term exposure to inorganic arsenic from drinking water and the risk of urothelial carcinoma (UC). Previous studies estimated the indices of inorganic arsenic exposure using environmental measurements, it could not actually reflect individual arsenic exposure in body. In addition, the standard level of arsenic in tap water was reduced from 50 μg/L to 10 μg/L since 2000 in Taiwan, and the same levels of Europeans and American were announced in 2003 and 2006, respectively. The purpose

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Chiu, Yueh-Hsia, and 邱月暇. "Genetic Polymorphisms in CYP1A1 and GSTM1 and T1 and Risk of Hepatocellular Carcinoma among Chronic Hepatitis B Carriers." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/38597490228666542522.

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碩士<br>國立臺灣大學<br>流行病學研究所<br>85<br>To investigate whether glutathione S-transferase（GST） M1 and T1 and cytochrome P450 1A1（CYP1A1）genetic polymorphisms were associated with susceptibility to hepatocellular carcinoma（HCC ）, a nest case-control study was carried out. Genotyping of GST M1 and T1 and CYP1A1 was performed using PCR-based methods on peripheral white blood cell DNA from 62 male HCC cases andb  age-matched male control. The controls were randomly selected from a cohort of male asymp

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Qiu, Yue-Xia, and 邱月暇. "Genetic Polymorphisms in CYP1A1 and GSTM1 and T1 and Risk of Hepatocellular Carcinoma among Chronic Hepatitis B Carriers." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/52228779244974476488.

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Tsai, ChingHuei, and 蔡慶慧. "Influence of genotypic polymorphism of CYP1A1 and GSTM1 on DNA-protein crosslinks in incinerator workers in hospital." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/33412074464906793822.

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碩士<br>中國醫藥學院<br>環境醫學研究所<br>89<br>Abstract The issue of environmental pollution in incinerating the medical waste has been concerned by the general public. In this study, DPC in peripheral blood lymphocytes were measured as an endpoint of cytogenetic damage. However, this kind of study is frequently complicated by variants confounding factors, both endogens (sex, age) and exogenous(life style, smoking , alcohol abuse ,diet habits etc.)In this study ,31 medical waste incinerator workers and 31 normal subjects as a matched control were enrolled. The purpose of the present study is to i

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Feng, Chen Ching, and 陳慶峰. "Effects of Genetic Polymorphisms of CYP1A1, UGT1A7 and GSTM1 on Urinary 1-OHP-gluc Concentrations among Toll Station Workers." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/02850740054251164047.

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碩士<br>國防醫學院<br>公共衛生學研究所<br>92<br>Motor vehicles are an important source of ambient air pollution in urban areas. The emission of traffic exhausts contain carcinogenic agents, such as polycyclic aromatic hydrocarbons (PAHs). Pyrene is commonly found in mixtures of PAHs, and its metabolites, such as 1-hydroxy pyrene (1-OHP) and 1-hydroxy pyrene glucuronide (1-OHP-gluc), can be measured in human urine. Genetic polymorphisms have been suggested to explain interindividual differences in the PAHs metabolizing enzymes. The aim of present study was to evaluate the influence of genetic polymorphisms on

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Shih, Kai-Wen, and 石凱文. "The Correlation between the Polymorphism of Glutathione S-transferases Pi 1(GSTP1) and Cisplatin- or Carboplatin-induced Nephrotoxicity." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/33559762868147472940.

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碩士<br>臺北醫學大學<br>藥學研究所<br>98<br>Background and aims: Cisplatin and carboplatin induced nephrotoxicity is a major dose-limiting factor for platinum-based treatments. Glutathione S-transferase Pi (GSTP) catalyzes the glutathione-conjugation as the first and the key step of nephrotoxin formation from platinum. Four functionally different polymorphisms of human GSTP, differed by A→G at 313 and C→T at 341, have been identified. Carrying A→G variation at 313 may cause higher catalytic efficacy for platinum than the wild-type does. The purpose of this study was to investigate the related risk fact

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Kubinski, Anja. "Evaluation von Clara Cell 16-(CC16) und Glutathion-S-Transferase P1-(GSTP1) Polymorphismen bei Frühgeborenen mit bronchopulmonaler Dsyplasie /." 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016246348&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Chen, Yeh-Hsin, and 陳業欣. "Effects of Genetic Polymorphisms of the Human PNP, CYT19 and GSTO1 on Individual Variation of Urinary Arsenic Metabolites after Oyster Ingestion." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/86761484438103103404.

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碩士<br>國立臺灣大學<br>職業醫學與工業衛生研究所<br>94<br>Abstract Food and drinking water are the major exposure routes of arsenic among the general population. In general, it was believed that the toxicity of inorganic arsenic was greater than organic arsenic. Up to now, inorganic arsenic is more thoroughly studied than organic arsenic. Consequently, the metabolism of organic arsenic has not been closely unveilded yet. However, there are considerable variations in the metabolism of inorganic and organic arsenic among individuals. Factors which have been shown to influence the methylation of arsenic include

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Carrica, Victoriano Andrés. "Polimorfismos genéticos como factores de riesgo en pacientes con desórdenes potencialmente malignos y cáncer bucal." Doctoral thesis, 2020. http://hdl.handle.net/11086/18822.

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Introducción: El cáncer bucal forma parte de un importante grupo de patologías denominadas Enfermedades Crónicas no Trasmisibles y se caracteriza por que su prevalencia e incidencia cambia de acuerdo al área geográfica, ambas asociadas a factores genéticos, a hábitos y costumbres propios de cada región o cultura. En países en vías de desarrollo como la Argentina, se enfrentan grandes desafíos por responder al aumento en la tasa de mortalidad y morbilidad de los últimos años y en el tratamiento y cuidados posteriores de pacientes con cáncer en estadios avanzados, considerándose una de las prin

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Chiou, Shih-Kang, and 邱士剛. "Benzo[a]pyrene-DNA Adducts in Lymphocyte and Genetic Polymorphism of CYP1A1 and GSTM1 of School Children in the Vicinity of a Medical Waste Incinerator." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/67743702372378805597.

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碩士<br>國立陽明大學<br>環境衛生研究所<br>90<br>Since medical waste contains plenty of plastic products, it would produce and then release high level of polycyclic aromatic hydrocarbons (PAHs) into the air during incineration. Human exposing to PAHs, Benzo[a]pyrene (B[a]P) especially, is related to the formation of DNA adduct and cancer. Furthermore, genetic polymorphism of metabolism enzymes is one of the factors that influence B[a]P-DNA adducts formation. Therefore, the aims of this study are to investigate B[a]P-DNA adducts of peripheral blood lymphocyte and genetic polymorphism of CYP1A1 and GSTM1 for sc

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Jai-Nien та 童瑞年. "The study of the pterygium pathogenesis in Taiwan:(I)An Association Between BPDE-Like DNA Adduct Levels and CYP1A1 and GSTM1 Polymorphisms(II)CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/98484517664812742504.

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博士<br>中山醫學大學<br>醫學研究所<br>99<br>(I)英文摘要 Purpose: BaP 7,8-diol 9,10-epoxide (BPDE), an ultimate metabolite of benzo(a)pyrene (BaP), attacks deoxyguanosine to form a BPDE-N2-dG adduct resulting in p53 mutations. Both cytochrome P4501A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) have been demonstrated to be involved in the metabolism of polycyclic aromatic hydrocarbons (PAHs). The relationship between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 gene polymorphisms in pterygium is not clear. Therefore, BPDE-like DNA adducts, and CYP1A1 and GSTM1 gene polymorphisms were detected in this s

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