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Rozprawy doktorskie na temat „GTP Homeostasis”

Autor: Grafiati
Data publikacji: 6 września 2023

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Sprawdź 17 najlepszych rozpraw doktorskich naukowych na temat „GTP Homeostasis”.

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1

Zolle, Lapuente Olga C. "Cyclic GMP and calcium homeostasis in endothelial cells." Thesis, University of Liverpool, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367654.

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2

Abrahamsson, Niclas. "On the Impact of Bariatric Surgery on Glucose Homeostasis." Doctoral thesis, Uppsala universitet, Institutionen för medicinska vetenskaper, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-276381.

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Obesity has grown to epidemic proportions, and in lack of efficient life-style and medical treatments, the bariatric surgeries are performed in rising numbers. The most common surgery is the Gastric Bypass (GBP) surgery, with the Biliopancreatic diversion with duodenal switch (DS) as an option for the most extreme cases with a BMI>50 kg/m2. In paper I 20 GBP-patients were examined during the first post-operative year regarding the natriuretic peptide, NT-ProBNP, which is secreted from the cardiac ventricles. Levels of NT-ProBNP quickly increased during the first post-surgery week, and later
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3

Lusche, Daniel Felix. "Cyclic GMP in the development of the social amoeba Dictyostelium discoideum regulation of calcium homeostasis by cGMP. /." [S.l. : s.n.], 2004. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB11482073.

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4

Schmitt, Charlotte. "Implication du transporteur intestinal GLUT2 dans l'absorption des sucres et la fonction entéroendocrine." Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066465.

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L'épithélium intestinal, en constant renouvellement, assure de nombreuses fonctions vitales comme l'absorption des nutriments et le maintien d'une barrière entre le milieu extérieur et l'organisme. L'absorption intestinale des sucres est assurée par de nombreux transporteurs au niveau de l'intestin proximal. Parmi eux, GLUT2, localisé dans les entérocytes et les cellules endocrines de l'intestin, transporte le glucose, le fructose et le galactose. Les cellules L entéroendocrines produisent le GLP-1, un puissant stimulateur de la sécrétion d'insuline en réponse au glucose. L'objectif de ma thès
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5

Berbel, Luciane Celeste Lazari. "Influência da variação genotípica Glu354Gln do receptor para o GIP sobre a homeostase glicêmica e a sensibilidade insulínica em indivíduos sadios." Universidade Estadual de Londrina. Centro de Ciências da Saúde. Programa de Pós-Graduação em Ciências da Saúde, 2014. http://www.bibliotecadigital.uel.br/document/?code=vtls000189459.

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A possível variabilidade na resposta fisiológica hormonal após a alimentação, relacionada à elevação do GIP pós-prandial entre indivíduos, despertou o interesse para avaliar a influência do polimorfismo no gene para o receptor do polipeptídeo insulinotrópico dependente de glicose (GIPR) na homeostase glicêmica e na função da célula beta pancreática. Foram estudados 25 adultos (12 mulheres, 13 homens) com IMC<30 e sem doenças relacionadas à síndrome metabólica. Foram coletadas amostras de sangue nos tempos basal (T0) e após refeição contendo 58g de carboidratos e 28g de lipídeos a cada 30 minut
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6

Ayari, Sami. "Implication des récepteurs nucléaires HNF-4α et HNF-4γ dans la fonction entéroendocrine et la susceptibilité à l'obésité et au diabète de type II". Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066380.

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L’obésité et le diabète de type 2 (DT2) sont des pathologies métaboliques associées à des perturbations de l’homéostasie glucidique et énergétique. Les enterohormones sont des acteurs importants de la regulation des mécanismes perturbés lors de ces pathologies. Parmi ces enterohormones, le GLP-1, sécrété par les cellules entéroendocrines de type L suite à un repas, permet d’amplifier la sécrétion d’insuline par les cellules β-pancréatiques et de diminuer la prise alimentaire. L’objectif de ma thèse a été de caractériser le rôle du récepteur nucléaire HNF-4γ dans l’homéostasie énergétique et la
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7

Domingues, Ana Sofia Jesus. "A reporter system to study the role of tRNA modifying enzymes in human proteostasis." Master's thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/21083.

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Mestrado em Biologia Molecular e Celular<br>A síntese proteica é um processo essencial para que todos os organismos mantenham a homeostasia celular. Os tRNAs são elementos cruciais na síntese proteica, uma vez que codificam a informação genética presente no mRNA. A linha celular HeLa, utilizada neste estudo, foi primeiramente isolada de uma mulher com cancro do colo do útero e desde então tem sido bastante usada na investigação, sendo muito importante no estudo das bases moleculares de muitas doenças. De modo a monitorizar a agregação proteica nesta linha celular, um sistema repórter
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8

Gupta, Kuldeepkumar Ramnaresh. "(p)ppGpp and c-di-GMP : A Tale of Two Second Messengers in Mycobacterium smegmatis." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/4117.

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Nucleotide based second messengers are known to regulate wide variety of processes in all domains of life. Two such bacterial second messengers are (p)ppGpp (guanosine tetra- or pentaphosphate) and c-di-GMP (cyclic dimeric guanosine monophosphate). The alarmone (p)ppGpp is synthesized by bacteria to face any kind of stress; while the signalling nucleotide c-di-GMP is synthesized principally to switch from motile (planktonic) to sessile (biofilm) life style. Apart from mediating the said functions, these nucleotides also regulate transcription, translation, replication, virulence and pathogenic
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9

Maida, Adriano. "Effects of Enteroendocrine Hormones on Beta-cell Function and Glucose Homeostasis." Thesis, 2011. http://hdl.handle.net/1807/29800.

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Mechanisms to augment the cellular function and mass of beta-cells may be effective means of treating type 2 diabetes. Important in the physiological control of beta-cell function and nutrient disposal are factors released from gut enteroendocrine cells during nutrient digestion. In enteroendocrine L-cells, post-translational processing of proglucagon gives rise to a number of proglucagon-derived peptides. One such peptide, glucagon-like peptide-1 (GLP-1), acts via its own receptor (GLP-1R) to stimulate beta-cell insulin secretion, proliferation and survival. Another, oxyntomodulin (OXM), weak
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10

Chiang, Yu-ting. "The Role of p21-activated Protein Kinase 1 in Metabolic Homeostasis." Thesis, 2014. http://hdl.handle.net/1807/44107.

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Our laboratory has demonstrated previously that the proglucagon gene (gcg), which encodes the incretin hormone GLP-1, is among the downstream targets of the Wnt signaling pathway; and that Pak1 mediates the stimulatory effect of insulin on Wnt target gene expression in mouse gut non- endocrine cells. Here, I asked whether Pak1 controls gut gcg expression and GLP-1 production, and whether Pak1 deletion leads to impaired metabolic homeostasis in mice. I detected the expression of Pak1 and two other group I Paks in the gut endocrine L cell line GLUTag, and co-localized Pak1 and GLP-1 in the mouse
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11

Marques, Filipa Carvalhal. "Mechanisms of aging: neuronal orchestration of stress resistance and protein homeostasis in the nematode Caenorhabditis elegans." Doctoral thesis, 2016. http://hdl.handle.net/10316/29393.

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Tese de doutoramento em Ciências da Saúde, no ramo de Ciências Biomédicas, apresentada à Faculdade de Medicina da Universidade de Coimbra<br>O envelhecimento é um processo complexo que ocorre em todos os organismos, da levedura ao Homem. Apesar de um século de pesquisa e discussão científica, os factores subjacentes à progressão do envelhecimento permanecem por clarificar. Mas os ângulos sob os quais este processo é visto sofreram grandes mudanças com o tempo. As primeiras teorias sugeriam que o envelhecimento decorre da acumulação estocástica de danos nas macromoléculas, levando ao mal funcio
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12

Correia, Ana Catarina Silva. "Expression of obesity-related genes in testes and sperm of rats subjected to caloric restriction and to GLP-1 administration." Master's thesis, 2021. http://hdl.handle.net/10773/32843.

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Caloric restriction (CR), due to its negative energy balance and GLP-1, for being an incretin, constitute two weight loss protocols that remain poorly investigated, particularly its impact on male reproductive function, whose proper functioning depends on a balanced energy homeostasis. That energy homeostasis has been related to genes linked to energy metabolism control, namely the obesity-related genes (ORGs), such as fat mass and obesity associated (FTO), melanocortin-4 receptor (MC4R), glucosamine-6- phosphate deaminase 2 (GNPDA2) and transmembrane protein 18 (TMEM18). Thus, thi
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13

STELITANO, VALENTINA. "Enzymes or signals? Functional characterization of Pseudomonas aeruginosa HD-GYP phosphodiesterases involved in the homeostasis of the second messenger c-di-GMP." Doctoral thesis, 2013. http://hdl.handle.net/11573/918076.

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14

Hsiao, Po-Yuan, and 蕭柏元. "Analysis of protein-protein interaction of the phosphate homeostatsis-related proteins by using tripartite split-GFP complementation assay in planta." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/7629xd.

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碩士<br>國立清華大學<br>生物資訊與結構生物研究所<br>106<br>ABSTRACT Tripartite split-GFP complementation assay is a new protein-protein interaction technique improved from bimolecular fluorescence complementation (BiFC). Tripartite split GFP system is composed of a larger fragment, GFP1-9 (residues 1–193), and two shorter β-strands : GFP10 (residues 194–212) and GFP11 (residues 213–233). There are some disadvantages of BiFC because BiFC is based on bulky fragments that may increase the difficulty of protein folding and interfere with protein function. To test whether tripartite split-GFP is a useful tool in plant
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15

Lusche, Daniel Felix [Verfasser]. "Cyclic GMP in the development of the social amoeba Dictyostelium discoideum : regulation of calcium homeostasis by cGMP = Die Rolle von cGMP für die Entwicklung der sozialen Amöbe Dictyostelium discoideum / Daniel Felix Lusche." 2004. http://d-nb.info/972598480/34.

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16

Araujo, Renata Sandres de Souza. "Controlling the effect of injection in the hypothalamus of diet induced obese mice." Master's thesis, 2020. http://hdl.handle.net/10400.1/17181.

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Diet-induced obesity causes a central inflammatory process in the brain, more specifically in the arcuate nucleus of the hypothalamus; in addition to substantially altering cholesterol homeostasis in the brain. The brain is one of the richest organs in cholesterol and cholesterol homeostasis has proved to be very important not only to maintain healthy brain physiology, but also directly influencing the whole-body homeostasis. In addition, several metabolic disorders are correlated with different neurodegenerative diseases. Cholesterol in the brain is converted primarily to 24-hydroxycholestero
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17

van, Rysewyk SP. "Pain is mechanism." Thesis, 2013. https://eprints.utas.edu.au/16767/2/whole_excl-images-vanrysewyk-thesis-2013.pdf.

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The mind-body problem is the problem: what is the relationship between mind and body? In this project, I claim that the relationship between the experience of pain and specific physiological mechanisms is best understood as one of type identity. Specifically, the personal experience of pain is an allostatic stress mechanism comprised of interdependent nervous, endocrine and immune operations. In Chapter One, I provide five reasons to prefer type identity theory of mind to dualistic philosophies of mind: it has greater explanatory power; it is more respectful of philosophical and folk intuitio
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