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Artykuły w czasopismach na temat „H2-receptor antagonist (H2RA)”

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Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Saroh, Muya, Agung Endro Nugroho, and I. Dewa Putu Pramantara. "Efektivitas H2-Receptor Antagonist dan Proton Pump Inhibitor sebagai Profilaksis Stress Ulcer pada Pasien dengan Ventilator Mekanik." Majalah Farmaseutik 20, no. 2 (2024): 211. http://dx.doi.org/10.22146/farmaseutik.v20i2.88994.

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Pasien kritis lebih berisiko mengalami stress ulcer yang dikarenakan oleh perubahan perfusi mukosa lambung, penurunan faktor pelindung mukosa dan peningkatan asam lambung, sehingga menyebabkan risiko perdarahan saluran pencernaan bagian atas. Pemberian profilaksis stress ulcer direkomendasikan pada pasien yang memiliki faktor risiko terjadinya perdarahan stress ulcer, terutama pasien dengan penggunaan ventilator mekanis. Penelitian ini bertujuan untuk mengetahui perbandingan efikasi PPI dan H2RA sebagai profilaksis stress ulcer pada pasien dengan penggunaan ventilator mekanis.Pada studi kohort

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Vashistha, Nitin, Dinesh Singhal, Gurpreet Makkar, Suneel Chakravarty, and Vivek Raj. "Management of Giant Gastric Ulcer Perforation: Report of a Case and Review of the Literature." Case Reports in Surgery 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/4681989.

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Giant gastric ulcer (GGU) is defined as an ulcer more than 3 cm in diameter. Now infrequent in clinical practice, in the pre-H2 receptor antagonist (H2RA) era, the incidence of GGU varied between 12 and 24% of all gastric ulcers. Proton pump inhibitors reportedly achieve better healing rates and symptom relief in comparison to H2RA. The GGU is associated with high incidence of serious complications such as hemorrhage. A perforated GGU though rare (<2%) offers serious challenges in management. We report one such case wherein the role of multidetector CT scan (MDCT) for diagnosis and treatmen

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3

Macaione, Francesca, Carla Montaina, Salvatore Evola, Giuseppina Novo, and Salvatore Novo. "Impact of Dual Antiplatelet Therapy with Proton Pump Inhibitors on the Outcome of Patients with Acute Coronary Syndrome Undergoing Drug-Eluting Stent Implantation." ISRN Cardiology 2012 (June 27, 2012): 1–8. http://dx.doi.org/10.5402/2012/692761.

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This study aimed to assess if proton pump inhibitors (PPIs) may reduce the effectiveness of clopidogrel, than H2 antagonist (anti-H2) in order to determine rehospitalization for acute coronary syndrome (re-ACS), target vessel revascularization (TVR) and cardiac death. This case-control study included 176 patients with ACS undergoing angioplasty (PCI) with drug-eluting stent implantation. The population was divided into two groups: PPI group (n=121) consisting of patients receiving at discharge dual antiplatelet therapy (DAT) plus PPI and anti-H2 group (n=55), consisting of patients receiving a

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4

Jiang, Mengyuan, Pan Chen, and Qiang Gao. "Systematic Review and Net-Work Meta-Analysis of Upper Gastrointestinal Hemorrhage Interventions." Cellular Physiology and Biochemistry 39, no. 6 (2016): 2477–91. http://dx.doi.org/10.1159/000452515.

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Background/Aims: Upper gastrointestinal hemorrhage (UGH) is a serious medical condition which affects a large number of individuals. Endoscopic therapy accompanied by medication is a standard approach that is used to improve the prognosis of UGH patients and a few medications have been developed including proton pump inhibitors (PPIs), histamine H2 receptor antagonist (H2RA), somatostatin analogues and tranexamic acid. This study is set to compare the efficacy and safety of various medical interventions that are used to manage upper gastrointestinal bleeding. Methods: We searched PubMed, Cochr

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5

Lin, Tsung-Kun, Chin-Feng Tsai, Jing-Yang Huang, Lung-Fa Pan, and Gwo-Ping Jong. "Exposure to Proton Pump Inhibitors and the Risk of Incident Asthma in Patients with Coronary Artery Diseases: A Population-Based Cohort Study." Journal of Personalized Medicine 12, no. 5 (2022): 824. http://dx.doi.org/10.3390/jpm12050824.

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We aimed to determine the association between proton pump inhibitor (PPI) use and incident asthma in patients with coronary artery disease (CAD). This nationwide cohort study collected claims data from the Taiwanese Bureau of National Health Insurance from 2004 to 2013. The primary outcome, i.e., the risk of incident asthma, was assessed by estimating hazard ratios (HRs) and 95% confidence intervals (CIs). The adjusted HR of asthma development was estimated using the Cox regression model. Sensitivity and subgroup analyses were also conducted. A total of 8894 PPI users and 12,684 H2-receptor an

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6

Abdul-Hussein, Mustafa, Janice Freeman, and Donald O. Castell. "Mo1149 Concomitant Administration of H2 Receptor Antagonist (H2RA) and Proton Pump Inhibitor (PPI). Reasonable or Ridiculous?" Gastroenterology 148, no. 4 (2015): S—621. http://dx.doi.org/10.1016/s0016-5085(15)32094-1.

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Mosholder, Andrew D., Hector S. Izurieta, Rongmei Zhang, et al. "Use of proton pump inhibitors and risk of severe COVID‐19: A case–control study in United States Medicare beneficiaries." Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 44, no. 10 (2024): 803–10. http://dx.doi.org/10.1002/phar.4614.

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AbstractBackgroundConcerns have been raised regarding proton pump inhibitor (PPI) use and risk of severe coronavirus disease 2019 (COVID‐19). Observational studies have yielded heterogeneous results and were subject to important methodological limitations.AimsTo examine the association between the receipt of PPIs and risk of COVID‐19 hospitalizations and severe in‐hospital outcomes or death.MethodsCase–control study among Medicare fee‐for‐service beneficiaries 66+ years old with gastroesophageal reflux disorder (GERD). Within this population, we identified cases by an incident hospital dischar

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8

Yamamichi, Nobutake, Takeshi Shimamoto, Yu Takahashi, et al. "Trends in proton pump inhibitor use, reflux esophagitis, and various upper gastrointestinal symptoms from 2010 to 2019 in Japan." PLOS ONE 17, no. 6 (2022): e0270252. http://dx.doi.org/10.1371/journal.pone.0270252.

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The increasing usage of proton pump inhibitors (PPIs) has been reported worldwide, but information on PPI use in East Asia is inadequate. This study aimed to examine the trends in PPI use in Japan, along with the changes in histamine H2 receptor antagonist (H2RA) use, disease rate of reflux esophagitis, and the prevalence of upper gastrointestinal symptoms. We analyzed 217,712 healthy subjects (127,607 men and 90,105 women; 51.4 ± 9.7 years old) participating in the health check program from 2010 to 2019. Various upper gastrointestinal symptoms were evaluated using the frequency scale for the

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9

FUKUDA, T., S. SAKURAI, and M. KUDO. "A STUDY ON THE RELATIONSHIP BETWEEN HELICOBACTER PYLORI AND TRACE ELEMENTS IN GASTRIC MUCOSA." International Journal of PIXE 16, no. 01n02 (2006): 55–68. http://dx.doi.org/10.1142/s0129083506000812.

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H2 receptor antagonist (H2RA) and proton pump inhibitor(PPI) are often used to treat gastric ulcers, in addition to the zinc-L-carcino-complex which is commonly adopted for such therapies. However, there have been no previous reports detailing the levels and distribution of zinc in human gastric mucosa. The aim of our current study is to clarify the relationship between Helicobacter pylori infection and trace elements such as zinc in gastric mucosa using particle induced X-ray emission (PIXE). Forty gastric ulcer patients were chosen as subjects of this study and divided into two groups. One i

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10

Park, Hyun Jin, Minoh Ko, In-Wha Kim, and Jung Mi Oh. "Personalized Risk Assessment for Taxane-Induced Hypersensitivity Reactions: A Systematic Review and Meta-Analysis." Journal of Personalized Medicine 15, no. 1 (2024): 2. https://doi.org/10.3390/jpm15010002.

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Background/Objectives: Taxanes, including paclitaxel and docetaxel, are widely used in cancer treatment but frequently cause hypersensitivity reactions (HSRs), disrupting treatment continuity. This meta-analysis aimed to identify consistent risk factors for taxane-induced HSRs to support personalized risk assessments and optimize therapeutic outcomes. Methods: This systematic review and meta-analysis followed the PRISMA guidelines and was registered with PROSPERO (CRD42023476738). Comprehensive literature searches were conducted up to 30 June 2024. The quality of the studies was assessed using

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11

Superceanu, Bogdan, Sander Veldhuyzen van Zanten, Chris Skedgel, Michael Shepherd, and Ingrid Sketris. "The Rate of Prescribing Gastrointestinal Prophylaxis with Either a Proton Pump Inhibitor Or an H2-Receptor Antagonist in Nova Scotia Seniors Starting Nonsteroidal Anti-Inflammatory Drug Therapy." Canadian Journal of Gastroenterology 24, no. 8 (2010): 481–88. http://dx.doi.org/10.1155/2010/397610.

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BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used agents that can cause serious gastrointestinal (GI) side effects. For patients at increased risk of NSAID-related GI complications, prophylaxis with either a nonselective NSAID plus gastroprotective agent (GPA) or, alternatively, therapy with a cyclooxygenase-2 selective inhibitor with or without a GPA such as a proton pump inhibitor (PPI), is recommended.AIM: To describe the rate, timing and duration of GI prophylaxis in Nova Scotia seniors receiving nonselective NSAIDs.METHODS: The Nova Scotia Seniors’ Pharmacare Progr

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12

Sharma, V. K., and C. W. Howden. "Cost-effectiveness of low- and standard dose lansoprazole compared with H2-receptor antagonist (H2RA) and placebo in patients with non-ulcer dyspepsia (NUD)." American Journal of Gastroenterology 95, no. 9 (2000): 2464. http://dx.doi.org/10.1111/j.1572-0241.2000.02541.x.

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Lindsay, Robert, Jay L. Goldstein, Xiaojie Zhou, and Christian Roux. "Risedronate Shows Consistent Reduction of The Risk of New Vertebral Fractures Over Three Years In Proton Pump Inhibitor (PPI) and H2-Receptor Antagonist (H2RA) Users." Journal of Clinical Densitometry 11, no. 3 (2008): 466. http://dx.doi.org/10.1016/j.jocd.2008.05.077.

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Liu, Jian, Swan Lin, Anthony Huynh, and Weiwei Tan. "Effects of H2-Receptor Antagonists on the Exposure of Dacomitinib." Pharmaceutics 16, no. 1 (2024): 118. http://dx.doi.org/10.3390/pharmaceutics16010118.

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Dacomitinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor indicated for the treatment of patients with advanced non-small-cell lung cancer (NSCLC) and EGFR-activating mutations. Proton-pump inhibitors decreased dacomitinib exposure. This analysis summarizes the effect of Histamine-2 receptor antagonists (H2RAs) on dacomitinib exposure. A within-patient comparison of the steady-state trough concentrations (Ctrough,ss) of dacomitinib and its active metabolite and active moiety with and without concomitant use of H2RAs was conducted using a linear mixed effe

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15

Anjewierden, Scott, Zheyi Han, Charles B. Foster, Chaitanya Pant, and Abhishek Deshpande. "Risk factors for Clostridium difficile infection in pediatric inpatients: A meta-analysis and systematic review." Infection Control & Hospital Epidemiology 40, no. 4 (2019): 420–26. http://dx.doi.org/10.1017/ice.2019.23.

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AbstractObjective:To summarize risk factors for Clostridioides (formerly Clostridium) difficile infection (CDI) in hospitalized pediatric patients as determined by previous observational studies.Design:Meta-analysis and systematic review.Patients:Studies evaluating risk factors for CDI in pediatric inpatients were eligible for inclusion.Method:We systematically searched MEDLINE, Web of Science, Scopus, and EMBASE for subject headings and text words related to CDI and pediatrics from 1975 to 2017. Two of the investigators independently screened studies, extracted and compiled data, assessed stu

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16

Octavia, Mega, Ade Achmad Firmansyah, and Ingenida Hadning. "OPTIMIZING STRESS ULCER PROPHYLAXIS: A CLINICAL AND COST EVALUATION IN RSUD WATES INTERNAL MEDICINE WARD." Medical Sains : Jurnal Ilmiah Kefarmasian 10, no. 2 (2025): 153–66. https://doi.org/10.37874/ms.v10i2.1637.

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The American Society of Health-System Pharmacists (ASHP) 1999 listed guidelines for providing stress ulcer prophylaxis (SUP) therapy as the standard of care for critical patients in the ICU. However, numerous studies have shown that most patients admitted to non-intensive care units continue to receive acid suppressant prescriptions, without appropriate indications or risk factors. This can lead to increased morbidity and increased patient care costs. This study aimed to determine the utilization profile of stress ulcer prophylaxis, its appropriateness, and the costs incurred by patients for S

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17

Force, Rex W., and Milap C. Nahata. "Effect of Histamine H2-Receptor Antagonists on Vitamin B12 Absorption." Annals of Pharmacotherapy 26, no. 10 (1992): 1283–86. http://dx.doi.org/10.1177/106002809202601018.

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OBJECTIVE: To discuss the potential of histamine H2-receptor antagonists (H2RAs) to cause malabsorption of vitamin B12 (cyanocobalamin). DATA SOURCES: Pertinent literature was identified via a MEDLINE search. Journals and references cited in published articles also were used as data sources. STUDY SELECTION: Studies evaluating the effect of H2RAs on vitamin B12 absorption were reviewed. DATA SYNTHESIS: H2RAs decrease acid secretion by the gastric parietal cells. Gastric acid and pepsin produced by these cells are required for the cleavage of vitamin B12 from dietary sources. Intrinsic factor (

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18

Wu, Chin-Chia, Chuan-Yin Fang, Wen-Yen Chiou, et al. "Proton Pump Inhibitors Worsen Colorectal Cancer Outcomes in Patients Treated with Bevacizumab." Cancers 16, no. 19 (2024): 3378. http://dx.doi.org/10.3390/cancers16193378.

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Background: Approximately one-third of patients with advanced colorectal cancer (CRC) and treated with bevacizumab are prescribed proton pump inhibitors (PPIs) or H2 receptor antagonists (H2RAs). However, there is limited data on the effects of PPIs and H2RAs in these patients. To investigate the oncological outcomes of PPI and H2RA use in CRC patients treated with bevacizumab, we performed a retrospective cohort study using the Taiwan National Health Insurance Research Database and Taiwan Cancer Registry Database from 2005 to 2020. Methods: In CRC patients treated with bevacizumab, the PPI us

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19

Shimozato, Akihiro, Makoto Sasaki, Naotaka Ogasawara, et al. "Risk Factors for Delayed Ulcer Healing after Endoscopic Submucosal Dissection of Gastric Neoplasms." Journal of Gastrointestinal and Liver Diseases 26, no. 4 (2017): 363–68. http://dx.doi.org/10.15403/jgld.2014.1121.264.kas.

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Background & Aims: With improved technology, the size of artificial ulcers after endoscopic submucosal dissection (ESD) has increased. The aim of our study was to examine the risk factors for delayed gastric ulcer healing after ESD, including the possible benefit of potassium-competitive acid blocker (P-CAB) treatment.Methods: The primary outcome was the rate of healing of the artificial ulcers induced by ESD at 8 weeks post intervention. Design: retrospective case series. Setting: Aichi Medical University Hospital. Patients: patients who underwent ESD for gastric neoplasm, between April 2

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KHAN, S., A. MUNEEB, and MS AHMAD. "COMPARATIVE EFFICACY OF PROTON PUMP INHIBITORS VS. H2 RECEPTOR ANTAGONISTS IN THE TREATMENT OF GASTROESOPHAGEAL REFLUX DISEASE." Biological and Clinical Sciences Research Journal 2024, no. 1 (2024): 1496. https://doi.org/10.54112/bcsrj.v2024i1.1496.

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Gastroesophageal reflux disease (GERD) is a common condition characterized by acid reflux into the esophagus, leading to symptoms such as heartburn and regurgitation. Objective: To compare the efficacy of Proton Pump Inhibitors (PPIs) and H2 Receptor Antagonists (H2RAs) in treating GERD in a cohort of 800 patients, assessing symptom relief, healing rates, and side effects. Methods: A total of 800 patients diagnosed with GERD were added to receive either PPIs (n=400) or H2RAs (n=400) for a treatment period of 8 weeks. The primary outcome was improved GERD symptoms, measured using a standardized

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Osawa, Satoshi, Masayoshi Kajimura, Seiji Yamamoto, et al. "Alteration of intracellular histamine H2 receptor cycling precedes antagonist-induced upregulation." American Journal of Physiology-Gastrointestinal and Liver Physiology 289, no. 5 (2005): G880—G889. http://dx.doi.org/10.1152/ajpgi.00536.2004.

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Long-term administration of a histamine H2 receptor (H2R) antagonist (inverse agonist) induces upregulation of H2R in parietal cells, which may be relevant to the rebound hypersecretion of gastric acid that occurs after withdrawal of treatment. The mechanisms underlying this effect are unknown. We hypothesized that the H2R upregulation could be related to receptor trafficking and used H2R-green fluorescent protein (H2R-GFP) to test the hypothesis. Human H2R-GFP was generated and functionally expressed in HEK-293 cells. Binding of the H2R antagonist [3H]tiotidine was performed to quantify H2R e

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Kawashima, Rei, Shun Tamaki, Fumitaka Kawakami, Tatsunori Maekawa, and Takafumi Ichikawa. "Histamine H2-Receptor Antagonists Improve Non-Steroidal Anti-Inflammatory Drug-Induced Intestinal Dysbiosis." International Journal of Molecular Sciences 21, no. 21 (2020): 8166. http://dx.doi.org/10.3390/ijms21218166.

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Dysbiosis, an imbalance of intestinal flora, can cause serious conditions such as obesity, cancer, and psychoneurological disorders. One cause of dysbiosis is inflammation. Ulcerative enteritis is a side effect of non-steroidal anti-inflammatory drugs (NSAIDs). To counteract this side effect, we proposed the concurrent use of histamine H2 receptor antagonists (H2RA), and we examined the effect on the intestinal flora. We generated a murine model of NSAID-induced intestinal mucosal injury, and we administered oral H2RA to the mice. We collected stool samples, compared the composition of intesti

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23

Athmann, Christoph, Ningxin Zeng, David R. Scott, and George Sachs. "Regulation of parietal cell calcium signaling in gastric glands." American Journal of Physiology-Gastrointestinal and Liver Physiology 279, no. 5 (2000): G1048—G1058. http://dx.doi.org/10.1152/ajpgi.2000.279.5.g1048.

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The ligands interacting with enterochromaffin-like (ECL) and parietal cells and the signaling interactions between these cells were investigated in rabbit gastric glands using confocal microscopy. Intracellular calcium concentration ([Ca2+]i) changes were used to monitor cellular responses. Histamine and carbachol increased [Ca2+]i in parietal cells. Gastrin (1 nM) increased [Ca2+]i in ECL cells and adjacent parietal cells. Only the increase of [Ca2+]i in parietal cells was inhibited by H2 receptor antagonists (H2RA). Gastrin (10 nM) evoked an H2RA-insensitive [Ca2+]i increase in parietal cell

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Neumann, Joachim, Maximilian Benedikt Binter, Charlotte Fehse, et al. "Amitriptyline functionally antagonizes cardiac H2 histamine receptors in transgenic mice and human atria." Naunyn-Schmiedeberg's Archives of Pharmacology 394, no. 6 (2021): 1251–62. http://dx.doi.org/10.1007/s00210-021-02065-7.

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AbstractWe have previously shown that histamine (2-(1H-imidazol-4-yl)ethanamine) exerted concentration-dependent positive inotropic effects (PIE) or positive chronotropic effects (PCE) on isolated left and right atria, respectively, of transgenic (H2R-TG) mice that overexpress the human H2 histamine receptor (H2R) in the heart; however, the effects were not seen in their wild-type (WT) littermates. Amitriptyline, which is still a highly prescribed antidepressant drug, was reported to act as antagonist on H2Rs. Here, we wanted to determine whether the histamine effects in H2R-TG were antagonize

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Shi, Zhongcheng, Robert S. Fultz, Melinda A. Engevik, et al. "Distinct roles of histamine H1- and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis." American Journal of Physiology-Gastrointestinal and Liver Physiology 316, no. 1 (2019): G205—G216. http://dx.doi.org/10.1152/ajpgi.00212.2018.

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Inflammatory bowel disease (IBD) is a well-known risk factor for the development of colorectal cancer. Prior studies have demonstrated that microbial histamine can ameliorate intestinal inflammation in mice. We tested the hypothesis whether microbe-derived luminal histamine suppresses inflammation-associated colon cancer in Apcmin/+ mice. Mice were colonized with the human-derived Lactobacillus reuteri. Chronic inflammation was induced by repeated cycles of low-dose dextran sulfate sodium (DSS). Mice that were given histamine-producing L. reuteri via oral gavage developed fewer colonic tumors,

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Pockes, Steffen, and Katharina Tropmann. "Histamine H2 receptor radioligands: triumphs and challenges." Future Medicinal Chemistry 13, no. 12 (2021): 1073–81. http://dx.doi.org/10.4155/fmc-2021-0058.

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Since the discovery of the histamine H2 receptor (H2R), radioligands were among the most powerful tools to investigate its role and function. Initially, radiolabeling was used to investigate human and rodent tissues regarding their receptor expression. Later, radioligands gained increasing significance as pharmacological tools in in vitro assays. Although tritium-labeling was mainly used for this purpose, labeling with carbon-14 is preferred for metabolic studies of drug candidates. After the more-or-less successful application of numerous labeled H2R antagonists, the recent development of the

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Gentilini, G., B. R. Curtis, and R. H. Aster. "An Antibody From a Patient With Ranitidine-Induced Thrombocytopenia Recognizes a Site on Glycoprotein IX That Is a Favored Target for Drug-Induced Antibodies." Blood 92, no. 7 (1998): 2359–65. http://dx.doi.org/10.1182/blood.v92.7.2359.

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Abstract Although thrombocytopenia associated with the use of histamine H2 receptor (H2R) antagonists has been described, a drug-dependent, platelet-reactive antibody has not previously been identified in such cases. We studied serum from a patient who developed acute, severe thrombocytopenia after exposure to the H2 receptor antagonist, ranitidine, and identified an antibody that reacted with normal platelets in the presence of this drug at pharmacologic concentrations. In flow cytometric and immunoprecipitation studies, the antibody was shown to be specific for the glycoprotein Ib/IX complex

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Gentilini, G., B. R. Curtis, and R. H. Aster. "An Antibody From a Patient With Ranitidine-Induced Thrombocytopenia Recognizes a Site on Glycoprotein IX That Is a Favored Target for Drug-Induced Antibodies." Blood 92, no. 7 (1998): 2359–65. http://dx.doi.org/10.1182/blood.v92.7.2359.2359_2359_2365.

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Although thrombocytopenia associated with the use of histamine H2 receptor (H2R) antagonists has been described, a drug-dependent, platelet-reactive antibody has not previously been identified in such cases. We studied serum from a patient who developed acute, severe thrombocytopenia after exposure to the H2 receptor antagonist, ranitidine, and identified an antibody that reacted with normal platelets in the presence of this drug at pharmacologic concentrations. In flow cytometric and immunoprecipitation studies, the antibody was shown to be specific for the glycoprotein Ib/IX complex (GPIb/IX

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Kelly, Deirdre A. "Do H2 Receptor Antagonists Have a Therapeutic Role in Childhood?" Journal of Pediatric Gastroenterology and Nutrition 19, no. 3 (1994): 270–76. http://dx.doi.org/10.1002/j.1536-4801.1994.tb11293.x.

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Summary: Studies of the therapeutic efficacy and indications for the use of histamine (H2)‐receptor antagonists (H2RAs) in children are reviewed. In adequate dosages, both ranitidine and cimetidine reduce acid output and increase intragastric pH, and H2RAs have been shown to be effective in the treatment of acid‐peptic disease. Ranitidine is a more potent drug with a longer duration of action than cimetidine and thus requires less frequent administration. Dosage requirements vary according to age and clinical condition, and children require a relatively higher drug dosage (mg/kg) than adults.

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Kou, Erwen, Xiaobei Zhang, Baiping Dong, Bo Wang, and Yuanjie Zhu. "Combination of H1 and H2 Histamine Receptor Antagonists: Current Knowledge and Perspectives of a Classic Treatment Strategy." Life 14, no. 2 (2024): 164. http://dx.doi.org/10.3390/life14020164.

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Histamine receptor antagonists, which can bind to specific histamine receptors on target cells, exhibit substantial therapeutic efficacy in managing a variety of histamine-mediated disorders. Notably, histamine H1 and H2 receptor antagonists have been extensively investigated and universally acknowledged as recommended treatment agents for numerous allergic diseases and acid-related disorders, respectively. Historically, the combination of H1 and H2 receptor antagonists has been considered a classic treatment strategy, demonstrating relatively superior efficacy compared with single-drug therap

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Niikura, Ryota, Yoku Hayakawa, Yoshihiro Hirata, et al. "The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion." International Journal of Molecular Sciences 20, no. 8 (2019): 1913. http://dx.doi.org/10.3390/ijms20081913.

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Background: Helicobacter pylori (H. pylori) eradication therapy may improve gastric atrophy and intestinal metaplasia, but the results of previous studies have not always been consistent. The aim of this study was to compare the histological changes of intestinal metaplasia and gastric atrophy among the use of acid-suppressing drugs after H. pylori eradication. Methods: A cohort of 242 patients who underwent successful eradication therapy for H. pylori gastritis and surveillance endoscopy examination from 1996 to 2015 was analyzed. Changes in the histological scores of intestinal metaplasia an

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Afshan, Siddiqui Mahesh Kumar Lohano Munir Ahmed Channa Aatir H. Rajput Muhammad Muneeb Abid Ali Anam Shaikh7 &. Tahir Hanif. "COMPARATIVE ANALYSIS OF SYMPTOM RELAPSE RATE FOLLOWING TREATMENT WITH PROTON PUMP INHIBITORS AND H2 RECEPTOR BLOCKERS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 11 (2018): 12562–65. https://doi.org/10.5281/zenodo.1490723.

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<strong><em>Background:</em></strong><em>H2-receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) are the primary classes of medication prescribed to treat gastroesophageal reflux disease (GERD) patients. Both classes of medication are safe and well tolerated, with a low risk of adverse events. However, they are often overused fearing symptom relapse following withdrawal of therapy.<strong>Objective:</strong>To study the symptom relapse rate following treatment withdrawal of PPIs and H2RAs and to compare the individual relapse rates.<strong>Methods:</strong>This cross-sectional, obser

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Jeon, Jimin, and Jinkwon Kim. "Risk of Post-Myocardial Infarction Pneumonia with Proton Pump Inhibitors, H2 Receptor Antagonists and Mucoprotective Agents: A Retrospective Nationwide Cohort Study." Journal of Personalized Medicine 12, no. 1 (2022): 78. http://dx.doi.org/10.3390/jpm12010078.

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Patients with myocardial infarction (MI) are at high risk of developing pneumonia. Proton pump inhibitors (PPI) and H2-receptor antagonists (H2RA) are commonly used acid-suppressive medications to the patients with MI for gastrointestinal (GI) protection, which may increase the risk for pneumonia. We evaluated whether PPI, H2RA, and mucoprotective agents without anti-acid properties increase the risk of post-MI pneumonia. We performed a retrospective cohort study based on the National Health Insurance Service—National Sample Cohort in Korea. The study included 3701 patients discharged with MI

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HOWDEN, C. "H2-receptor antagonists (H2RA) for bleeding peptic ulcer: the evidence revisited 16 years on." American Journal of Gastroenterology 96, no. 9 (2001): S57—S58. http://dx.doi.org/10.1016/s0002-9270(01)02918-5.

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Choi, Hyo Geun, Hong Kyu Lee, Ho Suk Kang, et al. "Possible Association between the Use of Proton Pump Inhibitors and H2 Receptor Antagonists, and Esophageal Cancer: A Nested Case–Control Study Using a Korean National Health Screening Cohort." Pharmaceuticals 15, no. 5 (2022): 517. http://dx.doi.org/10.3390/ph15050517.

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Although safety concerns regarding proton pump inhibitor (PPI)/H2-receptor antagonists (H2RA) in the incident esophageal cancer have been raised, the Asian-based report is unclear. We investigated the estimated likelihood of incident esophageal cancer—its mortality depending on prior history of PPI/H2RA use—and gastroesophageal reflux disease (GERD) in Koreans. Using the Korean National Health Insurance Service-Health Screening Cohort data (2002–2015), a case–control study was retrospectively conducted, including 811 patients with incident esophageal cancer and 3244 controls matched with sex,

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Almufleh, Aws, F. Daniel Ramirez, Derek So, et al. "H2 Receptor Antagonists versus Proton Pump Inhibitors in Patients on Dual Antiplatelet Therapy for Coronary Artery Disease: A Systematic Review." Cardiology 140, no. 2 (2018): 115–23. http://dx.doi.org/10.1159/000489165.

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Objectives: Mitigating the gastrointestinal (GI) bleeding risks of dual antiplatelet therapy (DAPT) is a common clinical concern. While proton pump inhibitors (PPIs) remain the most effective therapy, their adverse events warrant considering alternatives, including Histamine 2 receptor antagonists (H2RAs). Methods: We searched for randomized controlled trials in MEDLINE, EMBASE, PubMed, and Cochrane Central Register of Controlled Trials, published from 1980 to 2016. After screening, 10 trials were eligible. We compared PPIs to H2RAs in patients on DAPT in terms of 2 clinical and one laboratory

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Virk, Ghazala S., Sarah Hack, Hemamalini Anand Murugesan, et al. "Efficacy of Proton Pump Inhibitors vs. H2 Receptor Antagonists in Managing GERD: A Systematic Review and Meta-Analysis." Journal of Advances in Medicine and Medical Research 37, no. 4 (2025): 309–26. https://doi.org/10.9734/jammr/2025/v37i45805.

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This systematic review and meta-analysis aimed to compare proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) in treating gastroesophageal reflux disease (GERD), with a focus on symptom resolution and esophagus lining recovery. Out of a total of 10 studies on symptom relief involving 1,800 patients and 8 studies on mucosal healing outcomes comprising 1,400 patients, which were selected from relevant randomized controlled trials (RCTs), the results were pooled for the analysis. It was reported that PPIs gave a significantly greater effect on symptom relief than H2RAs, with a 35% b

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TUTUIAN, R., P. KATZ, F. AHMAD, M. PAMAGANAMAMULA, M. DIPIETRO, and D. CASTELL. "Over-the-counter (OTC) H2-receptor antagonists (H2RA) do not compromise the intragastric pH control with proton pump inhibitors (PPI's)." Gastroenterology 120, no. 5 (2001): A425. http://dx.doi.org/10.1016/s0016-5085(01)82107-7.

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Tutuian, Radu I., Philip O. Katz, Fawzia Ahmad, Madhu Pamaganamamula, Maria Dipietro, and Danald O. Castell. "Over-the-counter (OTC) H2-receptor antagonists (H2RA) do not compromise the intragastric pH control with proton pump inhibitors (PPI's)." Gastroenterology 120, no. 5 (2001): A425. http://dx.doi.org/10.1016/s0016-5085(08)82107-5.

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Kim, Seong Geun, Jeong Min Cho, Kyungdo Han, et al. "Non-indicated initiation of proton pump inhibitor and risk of adverse outcomes in patients with underlying chronic kidney disease: a nationwide, retrospective, cohort study." BMJ Open 14, no. 1 (2024): e078032. http://dx.doi.org/10.1136/bmjopen-2023-078032.

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ObjectiveEvidence related to the risk of kidney damage by proton pump inhibitor (PPI) initiation in patients with ‘underlying’ chronic kidney disease (CKD) remains scarce, although PPI use is generally associated with acute interstitial nephritis or incident CKD. We aimed to investigate the association between PPI initiation and the risk of adverse outcomes in patients with CKD in the absence of any deterministic indications for PPI usage.DesignRetrospective observational study.SettingKorea National Health Insurance Service database from 2009 to 2017.ParticipantsA retrospective cohort of new P

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Njei, Basile, Ivo Ditah, Julius Ngu, Nelvis Njei, and Alan Tita. "Proton Pump Inhibitors (PPIs) Versus H2-Receptor Antagonists (H2RAs) for Functional Dyspepsia: A Meta-analysis of Randomized Controlled Trials." American Journal of Gastroenterology 106 (October 2011): S497. http://dx.doi.org/10.14309/00000434-201110002-01306.

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Huang, J.-O., and RH Hunt. "Meta-analysis of comparative trials for healing erosive esophagitis (EE) with proton pump inhibitors (PPIS) and H2-receptor antagonists (H2RAs)." Gastroenterology 114 (April 1998): A154—A155. http://dx.doi.org/10.1016/s0016-5085(98)80627-6.

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Hassan, Ahmed I. "Utility of N-Bromosuccinimide as a Green Chemical Reagent for Determination of H2-Receptor Antagonists in their Pharmaceutical Dosage Forms." Acta Chemica Iasi 27, no. 1 (2019): 47–64. http://dx.doi.org/10.2478/achi-2019-0004.

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Abstract An environmentally safe, simple and robust spectrophotometric method has been developed for determination of H2-receptor antagonists namely: cimetidine (CIM), famotidine (FAM), nizatidine (NIZ), and ranitidine hydrochloride (RAN). The method was depend on the reaction of the studied drugs with N-bromosuccinimide (NBS), environmentally friendly reagent, and the excess NBS was measured by its reaction with phloroglucinol to give a yellow chromogenic product (λmax at 435 nm). The absorption intensity decrease (ΔA) was correlated with drug concentrations in the sample solutions. By using

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Kuo, Chia-Jung, Cheng-Yu Lin, Chun-Wei Chen, et al. "Risk of Enteric Infection in Patients with Gastric Acid Supressive Drugs: A Population-Based Case-Control Study." Journal of Personalized Medicine 11, no. 11 (2021): 1063. http://dx.doi.org/10.3390/jpm11111063.

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Long-term use of gastric-acid-suppressive drugs is known to be associated with several adverse effects. However, the association between enteric infection and acid suppression therapy is still uncertain. This study aimed to evaluate the association between gastric acid suppression and the risk of enteric infection. Materials and Methods: We conducted a population-based case-control study using the data from Chang Gung Research Database (CGRD) in Taiwan. Between January 2008 and December 2017, a total of 154,590 adult inpatients (age > 18) were identified. A pool of potential eligible contro

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van Zanten, Sander JO Veldhuyzen, Marc Bradette, Naoki Chiba, et al. "Evidence-Based Recommendations for Short- and Long-Term Management of Uninvestigated Dyspepsia in Primary Care: An Update of the Canadian Dyspepsia Working Group (CanDys) Clinical Management Tool." Canadian Journal of Gastroenterology 19, no. 5 (2005): 285–303. http://dx.doi.org/10.1155/2005/674607.

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The present paper is an update to and extension of the previous systematic review on the primary care management of patients with uninvestigated dyspepsia (UD). The original publication of the clinical management tool focused on the initial four- to eight-week assessment of UD. This update is based on new data from systematic reviews and clinical trials relevant to UD. There is now direct clinical evidence supporting a test-and-treat approach in patients with nondominant heartburn dyspepsia symptoms, and head-to-head comparisons show that use of a proton pump inhibitor is superior to the use o

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Chen, Ziyang, Tiantian Zhou, Yunfan Li, Tingting Li, Zhengnian Ding, and Li Liu. "Paraventricular Mast Cell-Derived Histamine Activates CRH Neurons to Mediate Adult Visceral Hypersensitivity Induced by Neonatal Maternal Separation." Brain Sciences 13, no. 11 (2023): 1595. http://dx.doi.org/10.3390/brainsci13111595.

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Neonatal maternal separation (NMS) is an early-life stress (ELS) that can result in adult visceral hypersensitivity, which is usually manifested as chronic visceral pain. Although mast cells and corticotropin-releasing hormone (CRH) neurons are involved in stress response, whether there is an interaction between mast cells and CRH neurons in hypothalamic paraventricular nucleus (PVN) during the ELS-induced visceral hypersensitivity remains elusive. Herein, we established an NMS model by separating neonatal mice from their mothers, and observed that these mice presented visceral hypersensitivit

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Alkhouri, H., V. Cha, K. Tong, L. M. Moir, C. L. Armour, and J. M. Hughes. "Human Lung Mast Cell Products Regulate Airway Smooth Muscle CXCL10 Levels." Journal of Allergy 2014 (February 6, 2014): 1–13. http://dx.doi.org/10.1155/2014/875105.

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In asthma, the airway smooth muscle (ASM) produces CXCL10 which may attract CXCR3+ mast/T cells to it. Our aim was to investigate the effects of mast cell products on ASM cell CXCL10 production. ASM cells from people with and without asthma were stimulated with IL-1β, TNF-α, and/or IFNγ and treated with histamine (1–100 μM) ± chlorpheniramine (H1R antagonist; 1 μM) or ranitidine (H2R antagonist; 50 μM) or tryptase (1 nM) ± leupeptin (serine protease inhibitor; 50 μM), heat-inactivated tryptase, or vehicle for 4 h or 24 h. Human lung mast cells (MC) were isolated and activated with IgE/anti-IgE

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Donnellan, Clare, Naveen Sharma, Cathryn Preston, Brendan C. Delaney, David Forman, and Paul Moayyedi. "A systematic review of the efficacy of proton pump inhibitors (PPIs), H2 receptor antagonists (H2RAs) and prokinetics in maintenance therapy of esophagitis." Gastroenterology 124, no. 4 (2003): A108—A109. http://dx.doi.org/10.1016/s0016-5085(03)80534-6.

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Orayj, Khalid. "Analyzing Prescribing Trends of Gastric Acid Suppressants in the UK Using Segmented Regression: Evaluating the Influence of COVID-19 (2019–2024)." Healthcare 13, no. 5 (2025): 442. https://doi.org/10.3390/healthcare13050442.

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Background: This study explored the prescribing patterns of proton pump inhibitors (PPIs) and histamine H2-receptor antagonists (H2RAs) across the UK during the COVID-19 pandemic, highlighting the dynamic relationship between emerging evidence, regulatory actions, and clinical practices. Methods: Using a repeated cross-sectional design, prescription data from July 2019 to May 2024 were analyzed across England, Scotland, Wales, and Northern Ireland. Segmented regression analysis was employed to assess trends before and after January 2022, reflecting the impact of emerging evidence on prescribin

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Petit, Laetitia-Marie, Franziska Righini-Grunder, Jessica Ezri, et al. "Prevalence and Predictive Factors of Histopathological Complications in Children with Esophageal Atresia." European Journal of Pediatric Surgery 29, no. 06 (2018): 510–15. http://dx.doi.org/10.1055/s-0038-1676505.

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Objectives Endoscopic follow-up after esophageal atresia (EA) tracheoesophageal fistula (TEF) repair is recommended to detect esophageal histopathological complications. We investigated the prevalence of histopathologically proven esophageal complications (peptic esophagitis, gastric metaplasia, and eosinophilic esophagitis) and assessed the predictors of these complications in children with EA-TEF. Materials and Methods This is a prospective longitudinal cohort study performed between September 2005 and December 2014 comprising 77 children with EA-TEF followed-up until February 2017. Univaria

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