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Rozprawy doktorskie na temat „Haematology”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Gray, Atherton. "Immunoliposomes in haematology." Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/26559.

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The aim of this thesis was to use antibody-directed liposomes to enhance the targeting of 1. fluorescent compounds for the detection of cell surface antigens and 2. cytotoxic compounds for delivery to specific cell populations. This involved the selection and production of a suitable species of liposome-protein conjugate from among those described in the literature. The choice was a small unilamellar liposome conjugated either to antibody or protein A via a covalent linkage mediated by the heterobifunctional reagent SPDP. Anti-immunoglobulin antibody was a more universal ligand than either spe

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2

Mainwaring, Gary. "Aspects of fish haematology." Thesis, Swansea University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627994.

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Swart, Luhan. "HIV-associated Hodgkin lymphoma at Groote Schuur Hospital, Western Cape, South Africa." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/27282.

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Background: Human immunodeficiency virus (HIV) is associated with an increased risk of developing Hodgkin lymphoma (HL). South Africa (SA) has the highest HIV prevalence rate in the world. There is currently no 5-year overall survival (OS) outcome based data for HIV-associated HL from SA. Methods: A bone marrow database was compiled of all bone marrow biopsies (BMB) reported at National Health Laboratory Service (NHLS) Groote Schuur Hospital (GSH) between January 2005 and December 2012. Patients who had a BMB performed for staging of HL or where HL was diagnosed on the BMB were included for fu

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Antel, Katherine. "Splenectomy for immune thrombocytopenia : our 11-year experience." Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/14134.

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Splenectomy has been practiced for the treatment of ITP for the past few decades. Currently it is utilised when a patient is either dependent or resistant to steroid treatment and the platelet count remains less than 30Ã—109/L. Recently new agents have been added to the armamentarium used to treat ITP, including immune-suppressants such as rituximab and the new thrombopoetin-receptor agonists. This has brought into question the role of surgery for the treatment of ITP, and the need to compare the response and complication rates of splenectomy to these newer agents. Historic studies done on spl

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Van, Schalkwyk Willem Adendorff. "The diagnostic utility of bone marrow biopsies performed for the investigation of fever and/or cytopenias in HIV-infected adults at Groote Schuur Hospital." Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/2834.

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This is a retrospective review of the results of consecutive bone marrow biopsies performed at our institution over a three year period on HIV positive patients for the investigation of fever and cytopenias. Clinical data, haematological parameters, morphology of bone marrow biopsy, Ziehl-Neelsen staining and microbiological culture results were analyzed. The aim of the study was to determine the diagnostic yield of this investigation.

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Makgoka, Seretloane Japhtaline. "Effects of bFGF (Basic Fibroblast growth factor) on the Haematopoietic Sequelae that follow transplantation." Master's thesis, University of Cape Town, 2000. http://hdl.handle.net/11427/25551.

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Recovery following bone marrow transplantation is associated with the reduction in the clonogenic potential of stroma-adherent CD34⁺ progenitors. The bone marrow stroma is also affected, resulting in poor support for the growth of stroma-adherent multipotent progenitors that form blastic colonies (CFU-bl). To determine the possible mechanisms of marrow damage in patients treated with peripheral blood stem cells (PBSCs) and bone marrow transplantation (BMT), we studied the effects of bFGF, a cytokine known to stimulate the survival and proliferation of fibroblasts, on the propagation of clonoge

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7

Seth, Yunus S. "Review and re-appraisal of patients treated with splenectomy for immune thrombocytopenic purpura at five years and beyond." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/2833.

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Includes bibliographical references.<br>The risk of pneumococcal infection post splenectomy is life long so all patients undergoing splenectomy are given polyvalent (23-valent) unconjugated pneumococcal polysaccharide vaccine, preoperatively. The aim of this study was 1. to measure the success of splenectomy at a tertiary institution at 5 years and beyond. 2. To review the incidence of complications peri-operatively and long term. 3. Review the need for possible re-vaccination (as recommended in American and British guidelines and 4. perform a re-appraisal of patients found to be refractory to

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8

Goolam, Hoosen Taahira. "Identification and characterisation of micrornas involved in the pathogenesis of HIV–associated non-Hodgkin's lymphoma." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/24883.

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Background: Since its discovery about three decades ago, the Human Immunodeficiency Virus (HIV) has claimed over millions of lives globally. Although our understanding of the mode of transmission and action of this causative agent for the Acquired Immune Deficiency Syndrome (AIDS) has increased through research, and treatment regimens developed and improved, in certain parts of the world the pandemic continues to expand. Sub-Saharan Africa, which is the epicentre of this global health concern, accounts for approximately 66% of the total number of individuals affected, with South Africa endurin

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9

Wu, Erxi. "Expression and regulation of ADAMs in cells derived from a range of haematological malignancies." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312292.

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10

Strouboulis, Ioannis John. "Regulation of the complete human #beta#-globin gene locus in transgenic mice." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.239790.

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11

Bruce, David. "Antithrombin : structural variants and thrombosis." Thesis, Open University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386084.

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12

Edgar, Paul Francis. "The structure and function of corticosteroid-binding globulin." Thesis, University of Cambridge, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263526.

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13

Ramorola, Beatrice Relebogile. "HIV alters the expression of miRNA hsa-miR-200c-3p in B-cells, leading to enhanced migration of lymphoma cells." Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29178.

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Background: The sub-Saharan African region is one that is affected most by the HIV/AIDS pandemic, with South Africa being the country with the highest number of infected individuals at 7.06 million. Infection with HIV is often associated with co-morbidities, including HIV-associated Non-Hodgkin’s Lymphomas (HIV-NHLs). Burkitt’s lymphoma (BL), a highly aggressive cancer, is one of the most common NHLs associated with HIV infection. Despite receiving highly active anti-retroviral therapy, the prognosis for this HIV-associated lymphoma remains poor and the incidence keeps on increasing in this gr

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14

Tremlett, Catherine H. "Molecular epidemiology of VanA resistant enterococci on a haematology ward." Thesis, University of Manchester, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499916.

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15

Paterson, Pamela J. "The diagnosis and treatment of invasive mould infections in haematology patients." Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425016.

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Histological appearances of many moulds overlap and there is a need for a method to allow identification in tissue specimens. Two methods for extracting fungal DNA from wax tissue sections, based on the TaKaRa DEXPAT <sup>TM</sup> kit and QIAamp<sup><span style='font-family:Symbol'>Ò </sup>DNA Mini Kit, were optimised and compared. DNA was amplified by PCR using pan-fungal primers, and detected by Southern blot hybridisation with a probe specific for <i>Aspergillus fumigatus </i>and <i>A. flavus. </i>The TaKaRa DEXPAT <sup>TM </sup> kit based method, with additional steps using lyticase and

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16

James, Rebecca. "A study of the neonatal haematology of children with Down syndrome." Thesis, University of York, 2011. http://etheses.whiterose.ac.uk/4063/.

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This thesis describes the establishment and initial findings of the Children with Down Syndrome Study, a birth cohort of children with DS. The Children with Down Syndrome Study was set up in order to characterise the haematology of neonates with Down syndrome and specifically to test the hypothesis that that this differed in this population. The study was carried out with the support of the Down Syndrome Association and the Down Syndrome Medical Interest Group, and through consultation with clinicians and families. Following a pilot study in the Yorkshire region it was established in over 60 h

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17

Pattipeiluhu, Shelly M. "A study of parasitic fauna of the flounder (Platichthys flesus L.) in the Tyne estuary." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295512.

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18

Mahmoud, T. T. "The haemocytes and heart activity of Episyrphus balteatus DeG. (Syrphidae: Diptera) and their response to environmental factors." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370147.

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19

Boyd, Helen Kathryn. "Erythropoietin and other growth factors in the anaemia of chronic disorders." Thesis, University of Newcastle Upon Tyne, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241268.

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20

Hassounah, Fadwa. "A study of some haemoglobinopathies using molecular genetic and mass spectrometric analytical techniques." Thesis, University of Salford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360389.

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21

Yong, Kwee Lan. "The effects of myeloid growth factors on phagocyte-endothelium interactions." Thesis, University College London (University of London), 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388120.

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22

Slupsky, Joseph R. "Mechanisms of monoclonal antibody-induced platelet activation." Thesis, University of Liverpool, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240868.

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23

Lwaleed, Bashir Abdulgader. "Urinary procoagulant activity in health and disease method development and clinical application." Thesis, University of Southampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390721.

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24

Atherton, Kirsten. "How do haematology patients make sense of clinical information? : a qualitative study." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2027839/.

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Haematological cancers are often unpredictable, leaving clinical decisions to be made throughout the trajectory of the illness. In this context, the way patients make sense of complex clinical information becomes particularly important. The study aimed to understand the ways in which patients make sense of clinical results, and to identify the psychological and other influences on this process. Semi-structured interviews were conducted with 20 patients who had been diagnosed with haematological cancer and had received results from clinical investigations or relating to treatment response. A co

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25

Booth, Christopher. "Collaboration of Ezh2 and Runx1 inactivating mutations in malignant haematopoiesis." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:3f3b18b1-5875-42ed-b025-cf0dd457b99f.

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Extensive efforts have shed light on the identity and biology of cancer stem cells, required and sufficient for the propagation of hematological malignancies and solid tumours. Much less is understood about the closely related issue as to the identity and properties of the normal stem and progenitor cells targeted by oncogenic lesions, and how the nature of the targeted cell might impact on the biology and clinical picture of the resulting cancer. To address this, we developed a mouse model allowing targeted inactivation of Ezh2 and Runx1 to different haematopoietic compartments. Inactivating

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26

Mallinson, Gary. "Characterisation of the erythrocyte membrane components which carry the antigens of the LW, Duffy and Cromer blood group systems." Thesis, University of the West of England, Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294721.

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27

Dyer, Greg Bryan. "Possible effects of HIV infection on overall survival of patients diagnosed with acute myeloid leukaemia." Diss., University of Pretoria, 2019. http://hdl.handle.net/2263/75830.

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Background The effects of Human Immunodeficiency Virus (HIV) on the Overall Survival (OS) in patients diagnosed with Acute Myeloid Leukaemia (AML) are not well documented. All studies to date have been with small sample sizes and based on collections of case studies from different facilities with different treatment protocols, as a result it has been difficult to draw definitive conclusions. Method This retrospective record review of a cohort of AML patients (n=304) treated at a single site between 2000 and 2017 was conducted. Age (16-93 years), gender (Male: n=157 ; Female: n=138)

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28

Caruana, Saviour. "Studies on arteriosclerotic pathologies, haematology, immunology and lipids of captive Atlantic bluefin tuna." Thesis, University of Stirling, 2014. http://hdl.handle.net/1893/21159.

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Commercial capture-based aquaculture of the Atlantic bluefin tuna (ABT), Thunnus thynnus (L.), has been prominent in the Mediterranean for over a decade. Owing to several limitations encountered in working with the species, including its high commercial value, there has been little research carried out relating to this species. The objective of this study was to examine several health parameters of captive ABT. These included an examination of coronary artery lesions, haematology, plasma biochemistry, assessment of immune function and changes in fatty acid (FA) flesh content through the on-gro

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Peck, Sarah Jane. "Haematology and Serum Biochemistry of Wild Tasmanian Devils with Devil Facial Tumour Disease." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14904.

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The Tasmanian devil (TD) is threatened with extinction by a fatally infectious cancer known as Devil facial tumour disease (DFTD). The objectives of this study were toestablish species reference intervals (RIs) and examine changes that occur in DFTD. Blood samples were collected from wild TDs at multiple sites in Tasmania. Significant age differences were found for ALP, CK, cholesterol, calcium, phosphate, albumin, globulin, albumin: globulin ratio and glucose. Significant differences between sexes were observed for AST, creatinine and potassium. Significant seasonal or reproductive statu

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30

Ng, Hon-yi, and 吳漢怡. "Evaluation of the new red cell parameters on Beckman Coulter DxH800 automated haematology analyzer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/202311.

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Objectives: The new red blood cell (RBC) parameters from automated haematology analyzers, such as reticulocyte haemoglobin content and percentage of hypochromic red cells or equivalent, are useful in the laboratory assessment of iron deficiency anaemia (IDA). However, the clinical utility of these parameters are confounded by thalassaemia trait (TT) especially in geographical areas of high thalassaemia prevalence. We aimed to evaluate the new formula derived from some red cell parameters on the Beckman Coulter DxH800 in distinguishing between IDA and TT in Hong Kong population. Methods: A t

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31

Stefan, Daniela Cristina. "Developing a framework for an undergraduate haematology curriculum in a Faculty of Health Sciences." Thesis, Stellenbosch : University of Stellenbosch, 2010. http://hdl.handle.net/10019.1/3187.

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Thesis (PhD (Curriculum Studies))--University of Stellenbosch, 2010.<br>ENGLISH ABSTRACT: The Faculty of Health Sciences at Stellenbosch University adopted a new set of guidelines for curriculum design in 1997, emphasising an orientation towards the requirements of the public sector general practice, a holistic approach and exposure to community lifestyle and disease patterns specific to various communities. In order to ensure the anchoring in the realities of the general practice, a family medical practitioner, appointed by the Academy of Family Practice, was included in the curriculum contro

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Walton, Shasheen. "Effects of season and cohort on the haematology of the geometric tortoise Psammobates geometricus." University of the Western Cape, 2012. http://hdl.handle.net/11394/4543.

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Magister Scientiae (Biodiversity and Conservation Biology) - MSc (Biodiv and Cons Biol)<br>The geometric tortoise is one of the world‟s rarest terrestrial tortoises and is endemic to the Southwestern Cape, South Africa. There has been cause for conservation concern for Psammobates geometricus, yet as is common for many species, quantitative physiological research has been lacking. Considering the important role of red blood cells in oxygen circulation, and the role of white blood cells in immune resistance, blood profiles have been used across taxa as a reliable indicator of health status and

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33

Donoghue, Alan M. "Acute heat illness in underground miners : the clinical state, haematology, biochemistry and risk factors." Thesis, Curtin University, 2000. http://hdl.handle.net/20.500.11937/2196.

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Objectives - To examine the incidence, clinical state, personal risk factors, haematology and biochemistry of heat exhaustion cases occurring at a deep underground metalliferous mine. To describe the underground and surface thermal conditions associated with the occurrence of heat exhaustion cases.Methods - A one-year prospective case-series of acute heat exhaustion cases was undertaken at a deep underground metalliferous mine in tropical and Australia. A case-control study of body mass index (BMI) and maximal oxygen uptake (VO(subscript)2max) in heat exhaustion was also undertaken. A history

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Donoghue, Alan M. "Acute heat illness in underground miners : the clinical state, haematology, biochemistry and risk factors." Curtin University of Technology, School of Public Health, 2000. http://espace.library.curtin.edu.au:80/R/?func=dbin-jump-full&object_id=11757.

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Objectives - To examine the incidence, clinical state, personal risk factors, haematology and biochemistry of heat exhaustion cases occurring at a deep underground metalliferous mine. To describe the underground and surface thermal conditions associated with the occurrence of heat exhaustion cases.Methods - A one-year prospective case-series of acute heat exhaustion cases was undertaken at a deep underground metalliferous mine in tropical and Australia. A case-control study of body mass index (BMI) and maximal oxygen uptake (VO(subscript)2max) in heat exhaustion was also undertaken. A history

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35

Fegan, C. D. "The gut mucosal barrier following bone marrow transplantation." Thesis, University of Newcastle Upon Tyne, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308776.

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AlSaeed, Abbas Habeeb. "The application of flow cytometeric and fluorescent microscopic techniques to the study of multiple myeloma." Thesis, University of Sheffield, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296727.

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37

Prinsloo, T. "The evaluation of a new haematological cell counter, the CELL-DYN 3500, on canine leukocyte differential counts." Diss., University of Pretoria, 2001. http://hdl.handle.net/2263/23383.

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Please read the abstract in the section 00 front of this document<br>Dissertation (M Med Vet (Clinical Laboratory Diagnostics))--University of Pretoria, 2001.<br>Companion Animal Clinical Studies<br>unrestricted

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38

Facchini, Raffaella Maria. "Investigating the specific roles of the growth factor kit ligand in the regulation of murine haematopoiesis." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:35da4965-5da9-4007-bf97-8408f0f5ed06.

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Maybury, Helena. "The characterisation of global haemostatic function during pregnancy and the puerperium using thromboelastography." Thesis, University of Leicester, 2007. http://hdl.handle.net/2381/10236.

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Chowdhury, Onima. "Characterisation and targeting of stem cells in myelodysplastic syndromes." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:741c2079-c6b3-46dc-b4d2-5708693e6cb3.

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Understanding which cells within a cancer are responsible for its initiation and propagation is vital if we are to achieve cure. If cancer stem cells are the only population able to sustain a tumour long term, designing therapeutic strategies to target this population will give medical science the best chance of long-term cure. Significant controversy remains over the existence of cancer stem cells, predominantly due to the lack of a sensitive human cancer stem cell assay. This thesis investigates whether two haematological malignancies, myelodysplastic syndromes (MDS) and chronic myelomonocyt

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41

Mussai, Francis Jay. "Immunotherapy and immunomodulation for haematological malignancies." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:6120e659-0dab-4447-b4d6-75e235d3b2c8.

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HA22 is an immunotoxin composed of an anti-CD22 variable fragment linked to a 38 kDa truncated protein derived from Pseudomonas exotoxin A. The mechanisms of cytotoxicity and resistance of HA22 against Acute Lymphoblastic Leukaemia (ALL) and Burkitt’s lymphoma were studied. Using a bone marrow mesenchymal cell culture assay to support ALL cell viability, I? investigated the in vitro cytotoxicity of HA22 against ALL blasts from newly diagnosed and relapsed patients. There was interpatient variability in sensitivity to HA22. There was no significant difference in HA22 sensitivity between diagnos

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42

Yeghen, Tullie. "Diagnosis and epidemiology of Aspergillus fumigatus and Aspergillus flavus infections by molecular techniques in haematology patients." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395541.

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Wolmarans, Wilhelm J. "The effect of transport on live weight loss, meat quality and blood haematology in slaughter ostriches." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6762.

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Thesis (MScAgric (Animal Sciences))--University of Stellenbosch, 2011.<br>ENGLISH ABSTRACT: The production and export of ostrich meat from southern Africa, to especially the European Union, are increasing rapidly due to the healthy nature of ostrich meat. The European Union has very high standards when importing food products, and it is inevitable that more emphasis is being placed on the production of high quality ostrich meat. Another aspect also of concern to consumers, is the welfare of animals prior to slaughter, and this forces producers to look at ways to decrease stress of anim

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no, nicolai@bonne, and Nicolai Johnsen Bonne. "Psittacine beak and feather disease : vaccination, haematological response and pcr methodology." Murdoch University, 2010. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20100211.182512.

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To enable assessment of recombinant BFDV capsid protein (recBFDVcap) for vaccination to protect against PBFD, commercially available lovebirds (Agapornis sp.) were tested for evidence of past and current BFDV infection using PCR, HI and HA to identify suitable BFDV-free birds in which to test the vaccine. During this attempt, it was found that lovebirds from commercial aviaries were endemically infected with BFDV with evidence of up to 100% prevalence of BFDV DNA in blood samples from individual birds over time. Such an approach was abandoned as unlikely to yield suitable numbers of naïve bird

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Sparks, Sharna. "Blood cell histology of Homopus areolatus: effects of season and cohort." University of the Western Cape, 2015. http://hdl.handle.net/11394/4776.

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Magister Scientiae (Biodiversity and Conservation Biology)<br>Homopus areolatus is an endemic terrestrial tortoise that resides in a Mediterranean type of climate, which is characterised by winter rainfall and mild winter temperatures. Within ectotherms, such as H. areolatus, physiological changes are elicited by changes in the ambient temperature. These physiological changes are evident in the blood profile of reptiles. I described the morphology of immature and mature erythrocytes, leukocytes as well as thrombocytes of H. areolatus. Additionally, I evaluated erythrocytes, leukocytes and thro

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46

Brandimarti, Maquel E. "Using haematology and biochemistry to investigate the health and evolutionary biology of eastern grey kangaroos (Macropus giganteus)." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/26627.

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Land clearing has detrimental and long-lasting impacts on natural ecosystems and biodiversity, yet land clearing is accelerating world-wide. The eastern grey kangaroo (Macropus giganteus) is a large common macropod that can reach high densities on cleared land. Despite their apparent success, kangaroo populations are susceptible to food shortages and increased disease risk. Developing a broad understanding of the drivers of kangaroo health is required to establish a benchmark to study poor health. This thesis aimed to develop an evidence-based tool that characterises kangaroo health. Species

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Moller, Cheryl. "The haematology of bobtail lizards (Tiliqua rugosa) in Western Australia: reference intervals, blood cell morphology, cytochemistry and ultrastructure." Thesis, Moller, Cheryl (2014) The haematology of bobtail lizards (Tiliqua rugosa) in Western Australia: reference intervals, blood cell morphology, cytochemistry and ultrastructure. Masters by Research thesis, Murdoch University, 2014. https://researchrepository.murdoch.edu.au/id/eprint/22862/.

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Bobtail lizards (Tiliqua rugosa) are native to Western Australia. Haematological evaluation is useful for health assessment: the only previous study of the haematology of this species sampled just six lizards (Canfield and Shea, 1988). The main aim of this study was to produce reference intervals for bobtail haematology. Over the summers of 2011/12 and 2012/13, heparinised venous blood was collected from 46 clinically healthy, captive adult bobtails in Perth. Complete blood counts and blood smear evaluations were performed. Cytochemical stains, transmission electron microscopy, and bone mar

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Philpott, Nicola Jane. "Apoptosis and the pathogenesis of aplastic anaemia." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.359983.

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Wong, Kah-Keng. "Validation of lymphoma-associated antigens identified using autoantibody profiling and protein arrays." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:51ac6bbe-2845-43cc-9b7a-cb92097155f1.

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Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma subtype with heterogeneous clinical outcome and a significant number of patients still die of their disease. Characterising lymphoma patients’ autoantibody repertoires represent one approach to improve the understanding of their disease biology. Our hypothesis was that characterisation of antigens eliciting humoural immune responses in lymphoma patients may provide insights into mechanisms of lymphomagenesis and identify novel diagnostic/therapeutic targets. HIP1R was validated as a novel B-NHL autoantigen by immunoblotting with p

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Lutteropp, Michael. "The emergence and early fate decisions of stem and progenitor cells in the haematopoietic system." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:eef3e876-bde2-4114-8ac2-bf0c87492a55.

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The alternative road map describes the separation of lympho-myeloid and myeloid-megakaryocyte-erythroid (myeloid-Mk-E) lineages as the earliest haematopoietic commitment event. However, a number of aspects of this lineage restriction process remain poorly understood. Herein this work identified a lympho-myeloid restricted progenitor in the embryo, which resembles the adult LMPP, and demonstrated that lymphoid lineage restriction is initiated prior to definitive haematopoiesis, much earlier than previously appreciated. In vivo fate mapping showed that lympho-myeloid progenitors significantly co

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