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Rozprawy doktorskie na temat „Helix”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Cabeza, Joaquin ZacariÌas. "Molecular mechanisms of helix-loop-helix proteins." Thesis, University of Essex, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442527.

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Sieber, Martin Sieber Martin. "DNA binding reaction of basic-helix-loop-helix proteins /." [S.l.] : [s.n.], 2000. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13578.

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Down, G. "Analysis of helix-loop-helix factors in the skin." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598622.

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There is little data regarding the action of HLH proteins in the skin. I have used RT-PCR Northern blotting analysis, immunocytochemistry (ICC) and in situ hybridisation (ISH) to determine the expression profiles of Id1, Id2, Id3 and Id4 and the Class A factors E2A, E2-2 and HEB mRNAs and proteins during human keratinocyte differentiation both <I>in vivo</I> and in monolayer and organotype <I>in vitro</I> differentiation culture models, and in the human anagen hair follicle, the rat hair follicle growth cycle, and the human sebaceous gland and eccrine sweat gland. Preliminary RT-PCR analysis d

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4

Fuchs, Angelika Johanna Maria. "Helix-helix interactions in membrane proteins : analysis, prediction and applications." kostenfrei, 2010. https://mediatum2.ub.tum.de/node?id=820985.

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5

Nilsson, Jonas. "Cooperative reactive sites in designed helix-loop-helix polypeptide catalysts /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/tek759s.pdf.

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6

Bloor, A. J. C. "Proteins for the basic helix-loop-helix transcription factor SCL." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596727.

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Members of the basic Helix-Loop-Helix (bHLH) family of transcription factors play critical roles in the control of development processes in species ranging from yeast to humans. The product of the <i>SCL</i> (Stem Cell Leukaemia) gene is a bHLH protein that was first identified by its ectopic expression in a case of childhood acute leukaemia and it has subsequently been characterised as a key player in the regulation of the development of blood and endothelium. The mechanism by which SCL functions are unclear, however it is likely that it regulates target genes by the formation of cell specifi

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7

Imabayashi, Takeshi. "Expression of basic helix-loop-helix proteins in the glomeruli." Kyoto University, 2001. http://hdl.handle.net/2433/150563.

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8

Saarikettu, Juha. "Calcium regulation and functions of basic Helix-Loop-Helix transcription factors." Doctoral thesis, Umeå : Department of Molecular Biology, Umeå University, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-537.

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9

King, Gavin W. "Investigating helix-helix interactions in the transmembrane domains of membrane proteins." Thesis, University of Warwick, 2009. http://wrap.warwick.ac.uk/3157/.

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Helix-helix interactions between membrane-spanning transmembrane (TM) domains have been shown to drive the assembly of α-helical membrane proteins within biological membranes. However, the rules that determine these interactions are not yet fully understood, despite such interactions being found in an increasing number of proteins. Recent work has implicated TM domain interactions in the formation of the protein complex Ii-MHC, formed from the association of Major Histocompatibility Complex Class II (MHC) and the MHC-associated-Invariant Chain (Ii) proteins. Following biosynthesis, three MHC α

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10

Ma, Philip Chun-Ming. "Structural studies on the basic-helix-loop-helix region from MyoD." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/28070.

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11

Massari, Mark Eben. "Transcriptional regulatory properties of the class I helix-loop-helix proteins /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1997. http://wwwlib.umi.com/cr/ucsd/fullcit?p9814549.

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12

Gutmann, Anja Franziska [Verfasser], and Ralph [Akademischer Betreuer] Wäsch. "Identifikation neuer Zielgene der Helix-Loop-Helix-Proteine der ID-Familie." Freiburg : Universität, 2011. http://d-nb.info/1123457867/34.

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13

Yang, Jing. "Investigation of the role of Id Helix-loop-helix proteins in neurogenesis." Thesis, University of Essex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517299.

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14

Dai, Nan. "I. Collagen-like polypeptides. II. Helix-turn-helix peptides and turn mimetics." Diss., Virginia Tech, 2008. http://hdl.handle.net/10919/28411.

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Collagen is one of the most important and abundant proteins in mammals. It consists of three left-handed PPII helixes coiled along a common axis to form a very compact right-handed super helix. The primary structure is shown to be (Gly-Xaa-Yaa)n repeats with high content of prolyl residues at both Xaa and Yaa positions. <i>Cis-trans</i> isomerization of the prolyl amide bonds is one of the rate-limiting steps during collagen triple helix folding. The conformationally locked alkene isosteres Fmoc-Gly-Ψ[(E)CH=C]-Pro-Hyp(tBu)-OH and Fmoc-Pro-Ψ[(E)CH=C]-Pro-OH were designed and synthesized. The s

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15

Sato, Tetsu. "The Basic Helix-Loop-Helix Gene hesr2 promotes gliogenesis in mouse retina." Kyoto University, 2004. http://hdl.handle.net/2433/148268.

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16

Schramm, Manuel. "Doppelhelix und triple helix." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-139021.

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17

Johnson, Benjamin C. F. (Benjamin Cedar Fruehauf). "Bio-inspired swimming helix." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77023.

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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 59-60).<br>This thesis investigated a bio-inspired swimming chain (BISH), inspired by Weelia cylindrica. After developing a model, it was used to investigate conditions under which helical motion would emerge. The properties of this chain as the number of nodes changes was also investigated, to see if the helical motion or other properties of its motion were emergent behaviors. Other modes of mot

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18

Hayward, Penelope Caroline. "The basic helix-loop-helix protein SCL and its role in haematopoietic development." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.603895.

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The SCL gene encodes a basic helix-loop-helix protein that has a critical role in the normal development of all haematopoietic lineages, as well as an oncogenic role in T cell leukaemogenesis. SCL is suspected to function as a tissue specific transcription factor, but the mechanisms by which SCL mediates its functions are unclear. Identification and characterisation of protein-protein interactions SCL should begin to unravel the roles of this protein. As SCL is expressed in committed erythroid, mast and megakaryocytic cells as well as early haematopoietic progenitor cells, yeast-two-hybrid scr

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19

Hufnagel, Robert B. "The Role of Basic Helix-Loop-Helix Transcription Factors in Early Retinal Neurogenesis." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1282932913.

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20

Van, Osselaer Christian. "Différenciation morphométrique et génétique de Helix pomatia L. 1758 et Helix lucorum L. 1758." Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211571.

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21

Bloor, Adrian John Clifton. "Identification of novel partner proteins for the basic helix-loop-helix transcription factor SCL." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.619716.

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22

Zhang, Fan. "Cloning and characterization of genes encoding basic helix loop helix (bHLH) proteins in Arabidopsis /." Full text (PDF) from UMI/Dissertation Abstracts International, 2000. http://wwwlib.umi.com/cr/utexas/fullcit?p9992950.

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23

Antonsson, Camilla. "Inducible and constitutive modes of gene regulation by the dioxin receptor and Arnt /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3438-X/.

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24

Braun, Marvin Herbert. "Anoxic survival in Helix aspersa." Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596873.

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The pulmonate snail, <i>Helix aspersa</i>, has the ability to survive long bouts of anoxia by depressing its metabolism. Direct calorimetry was used to measure the metabolic heat production of the snails in this state. During 24-48 hrs of anoxia, heat production varied with the oxygen levels and fell as low as 2% of that during normoxia. The <i>Helix </i>central nervosa system also depressed its metabolism during anoxia. Electrophysiological recordings revealed decreases in both action potential firing (spike arrest) and membrane conductance (channel arrest). These processes allow the maintena

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25

Cardew, Antonia. "Specificity of triple helix formation." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/183845/.

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Triplex-forming oligonucleotides (TFOs) have been the subject of extensive research in recent years. They have potential applications in many areas; such as gene-based therapies, site-directed mutation and as biochemical tools. However, triplex technology has been hampered by several problems, including low stability due to electrostatic repulsion between strands. This thesis has investigated combinations of four methods for stabilising triplex DNA; these include incorporation of the positively charged thymine analogues bis-amino-U and propargylamino-dU in TFOs. Also modified TFO’s containing

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26

Jhas, Sumitpal. "Regulation of cortical neuron and astrocyte differentiation by the basic helix loop helix protein Hes6." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18671.

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During development of the mammalian cerebral cortex, pluripotent neural progenitor cells located in the ventricular zone lining the lateral ventricles give rise to neurons, astrocytes, and oligodendrocytes. Neurogenesis precedes astrocyte differentiation, followed by oligodendrocyte differentiation. The mechanisms regulating the transition of undifferentiated progenitor cells into the differentiated state are regulated in part by basic-helix-loop-helix (bHLH) transcription factors of the Hairy/Enhancer of split (Hes) family. A number of Hes proteins are induced in response to the activation of

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27

Lara-Ramirez, Ricardo. "Lamprey neural Helix-Loop-Helix (HLH) genes and the evolution of the vertebrate nervous system." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:107e31ad-9183-4b07-842b-d01e27a4c9e6.

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Transcription factors of the helix-loop-helix (HLH) gene family are widespread in the animal kingdom. Among them, members of HLH subfamilies such as ASCL, Neurogenin, NeuroD, COE, Atonal, Oligo, NSCL, Hairy/E(spl) and Hey (here referred to as neural HLH genes) have been shown to be fundamental for the development of the nervous system. They are expressed at different time periods of neuronal differentiation, from the specification of ectoderm towards a neural lineage, to the ultimate differentiation of neurons. Few HLH genes have been identified in the lamprey; however, considering the wide di

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28

Narumi, Osamu. "OUT, a Novel Basic Helix-Loop-Helix Transcription Factor with an Id-like Inhibitory Activity." Kyoto University, 2000. http://hdl.handle.net/2433/180866.

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29

Walter, Monika. "Die parallele [beta]-Helix [Beta-Helix] der Pektat-Lyase aus Bacillus subtilis Stabilität, Faltungsmechanismus und Faltungsmutanten /." [S.l. : s.n.], 2002. http://pub.ub.uni-potsdam.de/2002/0027/walter.pdf.

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30

Yeung, Sze-chun, and 楊思俊. "Expression of regulatory Helix-loop-helix factor Id2 protein in the developing and adult mouse retina." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B29976649.

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31

Rivera, Richard Ramon. "The dominant negative helix-loop-helix proteins Id2 and Id3 are essential for proper lymphocyte development /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9907777.

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32

Olofsson, Susanne. "Design, synthesis, structure, and dynamics of a polypeptide with supersecondary structure a helix-loop-helix dimer /." Göteborg : Dept. of Organic Chemistry, University of Göteborg, 1994. http://books.google.com/books?id=6AdrAAAAMAAJ.

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33

McGee, Christopher J. "DNA helix imperfections Structure and flexibility /." Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2006. http://proquest.umi.com/login?COPT=REJTPTU0NWQmSU5UPTAmVkVSPTI=&clientId=3739.

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34

Janahmadi, Mahyar. "Ionic currents in Helix aspersa neurones." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318259.

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35

Ungless, M. A. "Conditioning in the snail, Helix aspersa." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242162.

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36

Washbrook, Elinor. "Alternate strand DNA triple helix formation." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242223.

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37

Azzarito, Valeria. "Versatile oligoamide α-helix mimetic scaffolds". Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/6888/.

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Protein-protein interactions (PPIs) play a pivotal role in mediating a number of biological processes involved in the development of infected or diseased states. Since α-helices constitute the most abundant motif at characterised protein interfaces, α-helix mediated PPIs represent an attractive target for therapeutic intervention and their inhibition with α-helix mimetics has emerged as a powerful strategy. Encouraging results have been obtained through the design of foldamers and proteomimetics and the current state-of-the-art is described in Chapter 1. The Wilson group is interested in the d

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38

Gornall, Joanne Louise. "The helix-coil transition in gelatin." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612077.

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39

Jenkins, Richard Owen. "High linearity broad-band helix TWTs." Thesis, Lancaster University, 2003. http://eprints.lancs.ac.uk/76591/.

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Helix travelling-wave tubes (TWTs) are extensively employed as final power amplifiers in satellites. These applications demand low spectral noise and high efficiency across a broad band. Research has been carried out to achieve these criteria in a helix TWT design. A deeper understanding has been gained on how the basic parameters of a TWT affect its non-linear performance. By selecting and controlling the parameters that are critical to the amplifier’s nonlinear performance the designs corresponding to the important and desired conditions have been identified. The main simulation tool for mod

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40

Wilman, Henry R. "Computational studies of protein helix kinks." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:21225f0e-efed-49c6-af27-5d3fe78fa731.

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Kinks are functionally important structural features found in the alpha-helices of many proteins, particularly membrane proteins. Structurally, they are points at which a helix abruptly changes direction. Previous kink definition and identification methods often disagree with one another. Here I describe three novel methods to characterise kinks, which improve on existing approaches. First, Kink Finder, a computational method that consistently locates kinks and estimates the error in the kink angle. Second the B statistic, a statistically robust method for identifying kinks. Third, Alpha Helic

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41

White, Barbara Anne Lindsay Carleton University Dissertation Sociology and Anthropology. "Bioculturalism revisited, the neurognostic helix uncoiled." Ottawa, 1995.

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42

Therien, James Patrick Daniel. "The Role of Transmembrane Domain Helix-Helix Interactions in the Function of Pentameric Ligand-Gated Ion Channels." Thesis, Université d'Ottawa / University of Ottawa, 2017. http://hdl.handle.net/10393/35643.

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The pentameric ligand gated ion channel super family plays a central role in fast synaptic communication between neurons and at the neuromuscular junction. Extensive studies on the prototypic pLGIC, the Torpedo nicotinic acetylcholine receptor (nAChR) have revealed an exquisite lipid sensitivity, with the nAChR adopting a novel uncoupled conformation in membranes lacking activating anionic and neutral lipids. The lipid-exposed transmembrane alpha-helix, M4, in each homologous subunit likely acts as a lipid sensor. One model proposes that activating lipids promote M4 “binding” to the adjacent a

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43

Wright, Lilyan Yi Tian. "The activity of the helix-loop-helix protein, E47, is regulated by the PI3K/Akt signaling pathway." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3258711.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed June 4, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.

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44

Altwaijry, N. A. S. "A novel coarse-grained molecular dynamics method for the accurate prediction of helix-helix interactions in GPCRs." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10044556/.

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This thesis describes a novel computational method developed to identify and characterise points of protein-protein interaction between two G protein-coupled receptors (GPCRs). An ensemble-based coarse-grained molecular dynamics (eCG-MD) approach was applied to GPCR oligomers with experimentally-determined contact interfaces (adenosine A2A receptor, rhodopsin, CXCR4 and β1AR). Error analysis was used to determine 1) the number of replicas in an ensemble and 2) the simulation time for each replica that were needed to obtain convergence with experimental results. Error analysis also enabled iden

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45

Kwok, Wai-kei. "Oncogenic function of TWIST in the development and progression of prostate cancer." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B3893825X.

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46

Hörzer, Jan Ruben. "Glycosylierte beta-Peptide als Oligosaccharidmimetika." [S.l. : s.n.], 2007.

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47

Liu, Tao. "Part 1 Synthesis of a potent histone deacetylase inhibitor; Part 2 Studies towards a stabilized helix-turn-helix peptide." Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/26019.

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The first part of this work describes the synthesis of a new histone deacetylase (HDAC) inhibitor (HDI). HDAC enzymes modify core histones, influence nucleosome structure and change gene transcription by removing the acetyl groups from lysine residues on proteins. HDIs are showing exciting potential as a new class of drugs for cancer and a variety of other diseases. A new HDAC inhibitor based on the hydroxamic acid motif has been synthesized. Two characteristic structural features were incorporated into the design of the novel inhibitor. A cyclic peptide mimetic of known structure was fused to

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48

MacAlister, Cora Ann. "The role of the basic helix loop helix transcription factor speechless in the initiation of the stomatal lineage /." May be available electronically:, 2009. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

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Qureshi, Tabussom. "Studying Transmembrane Helix Interactions in SDS micelles." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34417.

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The importance of interactions between transmembrane domains of integral membrane proteins has been well-established in a range of essential cellular functions. Most integral membrane proteins also possess regions that lie on the exterior of the membrane that may influence the ability of these transmembrane domains to interact. We sought to test this hypothesis by quantifying the energetics of transmembrane helix self-association in the absence and presence of an amphipathic helix that can bind to the membrane surface. The model chosen for this study was the major coat protein (MCP) of M13 ba

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50

Mansor, Mohd Fais Bin. "MIMO application for the quadrifilar helix antenna." Thesis, University of Surrey, 2012. http://epubs.surrey.ac.uk/770238/.

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Capacity increase of the current land mobile satellite (LMS) communication systems is highly desirable to cater for more data-centric applications such as broadcasting. Since the Multiple-input Multiple-output (MIMO) offers high spectral efficiency without additional bandwidth and transmit power, its implementation in the LMS system has been widely investigated in terms of channel characterisation, channel modelling and coding algorithms. However, the aspect of receive antenna design and its performance evaluation has not yet been considered even though it has enormous impacts on the system pe

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