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Rozprawy doktorskie na temat „Hepatocyte nuclear factor”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 lutego 2022

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1

Clissold, Rhian. "Identification of hepatocyte nuclear factor 1β-associated disease". Thesis, University of Exeter, 2017. http://hdl.handle.net/10871/31132.

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Heterozygous mutations and deletions of the gene that encodes the transcription factor hepatocyte nuclear factor 1β (HNF1B) are the commonest known monogenic cause of developmental kidney disease. However, diagnosis remains challenging due to phenotypic variability and frequent absence of a family history. There is also no consensus as to when HNF1B genetic testing should be performed. This thesis includes work looking at the identification of HNF1B-associated disease. An HNF1B score was developed in 2014 to help select appropriate patients for genetic testing. The aim in chapter 2 was to test

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Bingham, Coralie. "The renal manifestations of hepatocyte nuclear factor mutations." Thesis, University of Exeter, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269720.

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Hannoun, Zara. "Role of SUMO modification in hepatocyte differentiation." Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5917.

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Primary human hepatocytes are a scarce resource with variable function, which diminishes with time in culture. As a consequence their use in tissue modelling and therapy is restricted. Human embryonic stem cells (hESCs) could provide a stable source of human tissue due to their properties of self-renewal and their ability to give rise to all three germ layers. hESCs have the potential to provide an unlimited supply of hepatic endoderm (HE) which could offer efficient tools for drug discovery, disease modelling and therapeutic applications. In order to create a suitable environment to enhance H

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Chéret, Claire. "Spécificité et redondance des facteurs de transcription HNF1α (Hepatocyte Nuclear Factor-1α) et HNF1β/vHNF1 (Hepatocyte Nuclear Factor-1β/variant HNF1) chez la souris". Paris 6, 2002. http://www.theses.fr/2002PA066076.

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Gresh, Lionel. "Rôles du facteur de transcription hepatocyte nuclear factor 1beta au cours de l'organogenèse." Paris 6, 2004. http://www.theses.fr/2004PA066143.

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Chellappa, Karthikeyani. "Functional analysis of Tyrosine residues in human hepatocyte nuclear factor 4alpha." Diss., UC access only, 2009. http://proquest.umi.com/pqdweb?index=72&did=1790348311&SrchMode=1&sid=1&Fmt=7&retrieveGroup=0&VType=PQD&VInst=PROD&RQT=309&VName=PQD&TS=1270229827&clientId=48051.

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Thesis (Ph. D.)--University of California, Riverside, 2009.<br>Includes abstract. Includes bibliographical references (leaves 293-348). Issued in print and online. Available via ProQuest Digital Dissertations.

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Marable, Sierra S. "The Role of Hepatocyte Nuclear Factor 4a in Renal Proximal Tubule Development." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595849621045508.

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Papachristodoulou, Maria. "A study of the ligand-binding properties of hepatocyte nuclear factor 4Î± (HNF4Î±)." Thesis, University of Surrey, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.429895.

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Xu, Jianyu. "Mutations in the hepatocyte nuclear factor 1 and glucokinase genes in Southern Chinese patients with early-onset type 2 diabetes." Click to view the E-thesis via HKUTO, 2002. http://sunzi.lib.hku.hk/hkuto/record/B42576854.

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Karatza, Panagiota. "Characterization and functional analysis of the hepatocyte nuclear factor 1 alpha 5'-flanking region." Thesis, University of Leeds, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.423198.

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Stride, Amanda. "The phenotype of subjects with a mutation in the hepatocyte nuclear factor-1 alpha gene." Thesis, University of Exeter, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424848.

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Xu, Jianyu, and 許健瑜. "Mutations in the hepatocyte nuclear factor 1 and glucokinase genes in Southern Chinese patients with early-onset type 2 diabetes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B42576854.

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Ta, Tuong Chi. "The essential fatty acid linoleic acid is the endogenous ligand for the Orphan nuclear receptor Hepatocyte nuclear factor 4 Aplha." Diss., UC access only, 2009. http://proquest.umi.com/pqdweb?did=1871881951&sid=1&Fmt=7&clientId=48051&RQT=309&VName=PQD.

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14

Devonshire, Alison. "The role of hepatocyte nuclear factor 4α (HNF4α) in the metabolic regulation of its target genes". Thesis, University of Surrey, 2008. http://epubs.surrey.ac.uk/842743/.

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The nuclear receptor Hepatocyte Nuclear Factor 4a (HNF4a; NR2A1) regulates the transcription of many genes involved in glucose and lipid metabolism. Genetic linkage analyses have implicated HNF4a in the disease processes leading to Type 2 Diabetes Mellitus and dyslipidaemia. The aim of this study was to investigate the regulation of target genes in the metabolic pathways of glycolysis, lipogenesis and gluconeogenesis by HNF4a. Initally, the expression of HNF4a and its splice variants was investigated in three human hepatoma cell lines, HuH7, HepG2 and Hep3B, with the latter two cell lines show

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Okamoto, Takako. "Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma". Kyoto University, 2014. http://hdl.handle.net/2433/185193.

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Final article is available at "wileyonlinelibrary.com" Takako Okamoto,Masaki Mandai,Noriomi Matsumura,Ken Yamaguchi,Hiroshi Kondoh,Yasuaki Amano,Tsukasa Baba,Junzo Hamanishi,Kaoru Abiko,Kenzo Kosaka,Susan K. Murphy,Seiichi Mori,Ikuo Konishi "Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma" Molecular Carcinogenesis 54:35–49 (2013)<br>Kyoto University (京都大学)<br>0048<br>新制・論文博士<br>博士(医学)<br>乙第12804号<br>論医博第2076号<br>新制||医||1001(附属図書館)<br>80848<br>京都大学大学院医学研究科医学専攻<br>(主査)教授野田亮, 教授武藤学, 教授稲垣暢也<br>学位規則第4条第2項該当

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Gardner-Stephen, Dione Anne, and dione bourne@flinders edu au. "Transcriptional Regulation of Human UDP-Glucuronosyltransferases." Flinders University. Medicine, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20081111.223136.

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The UDP-glucuronosyltransferases (UGTs) are a superfamily of enzymes that glucuronidate small, lipophilic molecules, thereby altering their biological activity and excretion. In humans, important examples of UGT substrates include molecules of both endogenous and xenobiotic origin; thus, UGTs are considered essential contributors to homeostatic regulation and an important defence mechanism against chemical insult. In keeping with both roles, UGTs are most strongly expressed in the liver, a predominant organ involved in detoxification. Rates of glucuronidation in humans are neither uniform amon

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17

COFFINIER, CATHERINE. "Etude du profil d'expression et de l'inactivation du gene vhnf1 (variant hepatocyte nuclear factor 1) chez la souris." Paris 11, 1999. http://www.theses.fr/1999PA112104.

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Vhnf1 est un facteur de transcription a homeodomaine exprime dans les reins, le foie et le pancreas. Nous avons inactive ce gene chez la souris en remplacant son premier exon par le gene lacz. La detection de l'activite -galactosidase placee sous controle du promoteur de vhnf1 nous a permis de decrire finement le profil d'expression de ce gene, chez l'adulte et au cours du developpement. Nous avons ainsi montre l'expression particuliere de ce gene dans des structures epitheliales tubulaires telles que les canaux biliaires et pancreatiques et les tubules renaux. La mutation vhnf1, letale a l'et

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Nakajima, Naoki. "GATA6-positive lung adenocarcinomas are associated with invasive mucinous adenocarcinoma morphology, hepatocyte nuclear factor 4α expression, and KRAS mutations". Kyoto University, 2020. http://hdl.handle.net/2433/253168.

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Bunaciu, Rodica Petruta. "THE EFFECT OF POLYCHLORINATED BIPHENYLS ON LIVER TUMOR PROMOTION: A ROLE FOR KUPFFER CELLS?" Lexington, Ky. : [University of Kentucky Libraries], 2005. http://lib.uky.edu/ETD/ukynusi2005d00298/etd.pdf.

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Thesis (Ph. D.)--University of Kentucky, 2005.<br>Title from document title page (viewed on November 4, 2005). Document formatted into pages; contains viii, 188 p. : ill. Includes abstract and vita. Includes bibliographical references (p. 165-184).

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Briançon, Nadège. "Hepatocyte Nuclear Factor 4αʾ : régulation transcriptionnelle du promoteur distal et étude fonctionnelle des isoformes par "knock-in" réciproques chez la souris". Paris 6, 2005. http://www.theses.fr/2005PA066003.

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Yu, Li. "Genetic variation in the hepatocyte nuclear factor (HNF)-3α gene does not contribute to maturity-onset diabetes of the young in Japanese". Kyoto University, 2003. http://hdl.handle.net/2433/148693.

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Ren, Hui. "REGULATION OF HEPATIC GENE EXPRESSION DURING LIVER DEVELOPMENT AND DISEASE." UKnowledge, 2012. http://uknowledge.uky.edu/microbio_etds/6.

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My first project was to investigate the role of Hepatocyte Nuclear Factor 1 (HNF1) and Nuclear Factor I (NFI) on alpha-fetoprotein (AFP) promoter activity during liver development. AFP is highly expressed in the fetal liver, silenced at birth, and remains at very low levels in the adult liver. A GA substitution located at -119 of the human AFP promoter is associated with hereditary persistence of AFP (HPAFP) expression in the adult liver (Hum Molec Genet, 1993, 2:379). The -120 region harbors overlapping binding sites for HNF1 and NFI. While it has been shown that the GA substitution increas

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23

Arpiainen, S. (Satu). "Transcriptional regulation of the hepatic cytochrome P450 2a5 gene." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514285653.

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Abstract Cytochrome P450 (CYP) enzymes are the major metabolizers of xenobiotics, e.g. drugs, and environmental toxins. Thus, changes in CYP expression have an important impact on drug metabolism and susceptibility to chemical toxicity. In the present study, the transcriptional mechanisms of both constitutive and inducible regulation of the Cyp2a5 gene in mouse liver were investigated. Mouse primary hepatocyte cultures were used as the main model system together with cell and molecular biology methods. The key activation regions of the Cyp2a5 5' promoter were determined using reporter gene

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Eleswarapu, Satyanarayana. "Mechanisms of Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression in Liver." Diss., Virginia Tech, 2009. http://hdl.handle.net/10919/37373.

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The overall objective of this research was to understand the mechanims by which growth hormone (GH) regulates insulin-like growth factor-I (IGF-I) gene expression in liver. Previous studies have suggested that GH regulation of IGF-I gene expression in liver is mediated by binding of the transcription factor signal transducer and activator of transcription (STAT) 5 to four binding sites located distantly from the IGF-I promoter. The first specific objective of this research was to determine whether additional STAT5 binding sites were involved in GH stimulation of IGF-I gene expression in liver.

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Chardès, Brieux. "Inhibition du Virus de l’Hépatite Delta par des inducteurs de la voie NFκB". Thesis, Lyon, 2019. http://www.theses.fr/2019LYSE1141.

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La surinfection par le Virus de l'Hépatite Delta (HDV) de patients chroniquement infectés par le virus de l'hépatite B (HBV) est la forme la plus agressive d'hépatite virale chronique avec une progression plus rapide vers la cirrhose ainsi qu’un risque accru d'insuffisance hépatique et de carcinome hépatocellulaire. Environs 15 à 20 millions de personnes sont co-infectés par ces deux virus ; il s’agit d’une des coinfections la plus répandue et difficile à combattre au monde. Les traitements disponibles pour HBV ne sont pas efficaces contre HDV. L'unique option thérapeutique pour les patients c

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Rocha, Tatiana Marques Ferreira da. "Associação entre polimorfismos nos genes SLC2A1, SLC2A2, HNF1A, TGFB1 e DCP1A e nefropatia em portadores de diabetes mellitus tipo 1." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-26032013-141528/.

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A nefropatia diabética (ND) decorre da hiperglicemia crônica, de fatores de risco como a hipertensão arterial e a dislipidemia e de uma susceptibilidade genética já evidenciada em inúmeros estudos clínicos. Uma das características histológicas da ND é o acúmulo de proteínas de matriz extracelular no mesângio, para o qual contribuem várias vias bioquímicas. O GLUT-1, codificado pelo gene SLC2A1, é o principal transportador de glucose da célula mesangial e sua expressão está aumentada no glomérulo de animais diabéticos, o que constitui uma alça de feedback positivo pela qual a glicose extracelul

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Lee, Sihyi, та 李思怡. "Functional Analysis of Tilapia (Oreochromis mossambicus) Hepatocyte Nuclear Factor-3β Promoter Fragments". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/67540607462477019848.

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碩士<br>大葉大學<br>分子生物科技學系碩士班<br>100<br>The hepatocyte nuclear factors-3 (HNF-3) family members HNF-3α, HNF-3β and HNF-3γ are hepatocyte-enriched transcription factors, they play important roles in controlling development, differentiation, metabolism and organogenesis. In our previous study, the expression of insulin-like growth factor-I/II (IGF-I/II), HNF-1α, -1β and -3β were detected in the liver and gonads of tilapia, and expreession level of HNF-3β was higher than others and it could be regulated by 17β-estradiol. In this study, four fragments (0.5, 1.0, 1.5 and 2.0 kb) of tilapia HNF-3β pro

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Krajewski, Jochen Christian [Verfasser]. "Die Bedeutung des Transkriptions-hepatocyte-nuclear-factor-4α [Transkriptions-hepatocyte-nuclear-factor-4-alpha] für die Repression des Erythropoietin-Gens durch {Interleukin-1β [Interleukin-1-beta] / vorgelegt von Jochen Christian Krajewski". 2006. http://d-nb.info/984150412/34.

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Chih-Chien, Hsu, and 許志堅. "Molecular Cloning and Localization of The Tilapia (Oreochromis mossambicus)Hepatocyte Nuclear Factor (HNF)-4a." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/14789305249316826974.

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碩士<br>大葉大學<br>分子生物科技學系碩士班<br>94<br>Hepatocyte nuclear factor (HNF)-4 is a liver-enriched transcription factor and belongs to the highly conserved member of the nuclear receptor superfamily. HNF-4 together with other factors play a key role in the tissue specific expression of a large number of genes involved in lipid and glucose metabolism. However, its function in fish is still poorly understood. In our previous study, RNAs and proteins of HNF-1, HNF-1, and HNF-3are detected in the liver, ovary, and testis of tilapia (Oreochromis mossambicus). And the expression of HNF-3 in the gonads

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Chen, Hue-Ling, and 陳惠玲. "The Cloning and Regulatory Analysis of Tilapia (Oreochromis mossambicus) Hepatocyte Nuclear Factor-3b Promoter." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/22124471280928720560.

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碩士<br>大葉大學<br>分子生物科技學系碩士班<br>94<br>The hepatocyte nuclear factors-3 (HNF-3) family members HNF-3, HNF-3 and HNF-3 are hepatocyte-enriched transcription factors, they play important roles in controlling development, cell differentiation, organogenesis and in the regulation of metabolism. In our previous study, the expression of insulin-like growth factor-I (IGF-I), IGF-II, HNF-1a, -1b, and -3bwere detected in the liver and gonads of tilapia, and the expression level of HNF-3b was higher than others and it could be regulated by 17b-estradiol. Based on the results, the aim of this study was

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Hsu, Yu-Hua, та 許育華. "Regulation of hepatocyte nuclear factor 4 alpha (HNF4α) expression in hepatocellular carcinoma cell lines". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/51626457187763530687.

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碩士<br>慈濟大學<br>人類遺傳研究所<br>94<br>It has been reported that in mouse hepatogenesis HNF4α is essential for the expression of E-cadherin in the organ formation. Thus if HNF4α is down-regulated the consequence would be the lost of polarity and increase in cell mobility and invasiveness of hepatocyte. Whether HNF4α can regulate metastasis of human hepatoma cell has not been determined yet. It has been reported that in most hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC) SMYD3, a histone methyaltranferase, was over expressed. SMYD3 can down-regulate HNF4α. The decreased HNF4αexpression

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Yu, Hao-Cheng, and 余浩成. "Studies on the Tilapia (Oreochromis mossambicus) Hepatocyte Nuclear Factor-1 and -3 in the Regulation of Reproductive System." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/23254843122837346213.

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碩士<br>大葉大學<br>分子生物科技學系碩士班<br>93<br>Tilapia is the most general aguacultivating fish in the fresh water and has characteristics of fast growing and well disease resistance. Thus tilapia is an important animal model for relative aquaculture researches. Hepatocyte nuclear factors (HNFs) are liver-enriched transcription factors, which can activate the expressions of tissue-specific, growth and development related genes. The expression of HNFs was detected in the gonads of tilapia previously, and which could be regulated by steroid hormones. Therefore, the reproductive system in tilapia could exi

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Cliff, Ji-Fan Lin, and 林致凡. "Two Isoforms of Hepatocyte Nuclear Factor 1-alpha (HNF1-alpha) in Tilapia (Oreochromis mossambicus) Which Transactivate IGF-I Gene Expression." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/79388460468221975578.

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碩士<br>國立海洋大學<br>水產生物技術研究所<br>87<br>The liver-enriched hepatocyte nuclear factor 1 (HNF1) is an important transcription factor for IGF-I in adult liver. Only one conserved HNF1 binding site was found near the transcription initiation site of tilapia IGF-I gene. To study the role of HNF1 in the signaling pathway of GH-IGF-I axis, degenerated primers designed from known sequences of HNF1 were used to amplify HNF1 partial sequence from tilapia liver mRNA by one step RT-PCR. After gel electrophoresis, RT-PCR product revealed two major bands in size of 400 and 500 bps. Sequence comparisons of these

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Michaud, Josée. "L’inhibition des cytochromes P450 dans les cas d’insuffisance rénale chronique : rôle de l’hormone parathyroïdienne." Thèse, 2012. http://hdl.handle.net/1866/10228.

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