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Artykuły w czasopismach na temat „Hepatocyte nuclear factor”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 lutego 2022

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1

Eeckhoute, J. "Hepatocyte Nuclear Factor 4 enhances the Hepatocyte Nuclear Factor 1 -mediated activation of transcription." Nucleic Acids Research 32, no. 8 (April 28, 2004): 2586–93. http://dx.doi.org/10.1093/nar/gkh581.

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Sund, Newman J., Siew-Lan Ang, Sara Dutton Sackett, Wei Shen, Nathalie Daigle, Mark A. Magnuson та Klaus H. Kaestner. "Hepatocyte Nuclear Factor 3β (Foxa2) Is Dispensable for Maintaining the Differentiated State of the Adult Hepatocyte". Molecular and Cellular Biology 20, № 14 (15 липня 2000): 5175–83. http://dx.doi.org/10.1128/mcb.20.14.5175-5183.2000.

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ABSTRACT Liver-specific gene expression is controlled by a heterogeneous group of hepatocyte-enriched transcription factors. One of these, the winged helix transcription factor hepatocyte nuclear factor 3β (HNF3β or Foxa2) is essential for multiple stages of embryonic development. Recently, HNF3β has been shown to be an important regulator of other hepatocyte-enriched transcription factors as well as the expression of liver-specific structural genes. We have addressed the role of HNF3β in maintenance of the hepatocyte phenotype by inactivation ofHNF3β in the liver. Remarkably, adult mice lacki

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3

ULVILA, Johanna, Satu ARPIAINEN, Olavi PELKONEN, Kaoru AIDA, Tatsuya SUEYOSHI, Masahiko NEGISHI, and Jukka HAKKOLA. "Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I." Biochemical Journal 381, no. 3 (July 27, 2004): 887–94. http://dx.doi.org/10.1042/bj20040387.

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The cytochrome P4502a5 (Cyp2a5) gene is expressed principally in liver and olfactory mucosa. In the present study, the transcriptional mechanisms of hepatocyte-specific expression of Cyp2a5 were studied in mouse primary hepatocytes. The Cyp2a5 5′-flanking region −3033 to +10 was cloned in front of a luciferase reporter gene and transfected into hepatocytes. Deletion analysis revealed two major activating promoter regions localized at proximal 271 bp and at a more distal area from −3033 to −2014 bp. The proximal activation region was characterized further by DNase I footprinting, and a single c

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4

Wang, Zhongyan, та Peter A. Burke. "Hepatocyte nuclear factor-4α interacts with other hepatocyte nuclear factors in regulating transthyretin gene expression". FEBS Journal 277, № 19 (23 серпня 2010): 4066–75. http://dx.doi.org/10.1111/j.1742-4658.2010.07802.x.

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5

Gardner-Stephen, Dione A., та Peter I. Mackenzie. "Hepatocyte nuclear factor1 transcription factors are essential for the UDP-glucuronosyltransferase 1A9 promoter response to hepatocyte nuclear factor 4α". Pharmacogenetics and Genomics 17, № 1 (січень 2007): 25–36. http://dx.doi.org/10.1097/fpc.0b013e32801112b5.

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6

Khurana, Satish, Amit K. Jaiswal та Asok Mukhopadhyay. "Hepatocyte Nuclear Factor-4α Induces Transdifferentiation of Hematopoietic Cells into Hepatocytes". Journal of Biological Chemistry 285, № 7 (16 грудня 2009): 4725–31. http://dx.doi.org/10.1074/jbc.m109.058198.

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7

Tian, J. M., and U. Schibler. "Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4." Genes & Development 5, no. 12a (December 1, 1991): 2225–34. http://dx.doi.org/10.1101/gad.5.12a.2225.

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8

Aboudehen, Karam, Min Soo Kim, Matthew Mitsche, Kristina Garland, Norma Anderson, Lama Noureddine, Marco Pontoglio та ін. "Transcription Factor Hepatocyte Nuclear Factor–1βRegulates Renal Cholesterol Metabolism". Journal of the American Society of Nephrology 27, № 8 (28 грудня 2015): 2408–21. http://dx.doi.org/10.1681/asn.2015060607.

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9

Freedman, A. R., R. J. Sharma, G. J. Nabel, S. G. Emerson та G. E. Griffin. "Cellular distribution of nuclear factor κB binding activity in rat liver". Biochemical Journal 287, № 2 (15 жовтня 1992): 645–49. http://dx.doi.org/10.1042/bj2870645.

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The cellular localization of nuclear factor kappa B (NF-kappa B) binding activity in rat liver has been investigated using electrophoretic mobility shift assay on extracts of highly purified hepatocytes and Kupffer cells obtained from liver perfused in vivo with collagenase. Constitutive NF-kappa B binding activity was demonstrated in nuclear extracts of control Kupffer cells, and this was not apparently influenced by injection of lipopolysaccharide (LPS) into rats 24 h before perfusion. In contrast, little nuclear NF-kappa B binding activity was present in hepatocytes from control animals, al

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10

Tang, Hong, and Alan McLachlan. "Avian and Mammalian Hepadnaviruses Have Distinct Transcription Factor Requirements for Viral Replication." Journal of Virology 76, no. 15 (August 1, 2002): 7468–72. http://dx.doi.org/10.1128/jvi.76.15.7468-7472.2002.

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ABSTRACT Hepadnavirus replication occurs in hepatocytes in vivo and in hepatoma cell lines in cell culture. Hepatitis B virus (HBV) replication can occur in nonhepatoma cells when pregenomic RNA synthesis from viral DNA is activated by the expression of the nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and the retinoid X receptor α (RXRα) plus peroxisome proliferator-activated receptor α (PPARα) heterodimer. Nuclear hormone receptor-dependent HBV replication is inhibited by hepatocyte nuclear factor 3 (HNF3). In contrast, HNF3 and HNF4 support duck hepatitis B virus (DHBV) repli

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11

Pierreux, C. E., J. Stafford, D. Demonte, D. K. Scott, J. Vandenhaute, R. M. O'Brien, D. K. Granner, G. G. Rousseau, and F. P. Lemaigre. "Antiglucocorticoid activity of hepatocyte nuclear factor-6." Proceedings of the National Academy of Sciences 96, no. 16 (August 3, 1999): 8961–66. http://dx.doi.org/10.1073/pnas.96.16.8961.

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12

Dmitrieva, Renata I., Cruz A. Hinojos, Eric Boerwinkle, Michael C. Braun, Myriam Fornage, and Peter A. Doris. "Hepatocyte Nuclear Factor 1 and Hypertensive Nephropathy." Hypertension 51, no. 6 (June 2008): 1583–89. http://dx.doi.org/10.1161/hypertensionaha.108.110163.

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13

Lannoy, Vincent J., Annie Rodolosse, Christophe E. Pierreux, Guy G. Rousseau, and Frédéric P. Lemaigre. "Transcriptional Stimulation by Hepatocyte Nuclear Factor-6." Journal of Biological Chemistry 275, no. 29 (May 12, 2000): 22098–103. http://dx.doi.org/10.1074/jbc.m000855200.

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14

Wang, Kewei, and Ai-Xuan Holterman. "Pathophysiologic role of hepatocyte nuclear factor 6." Cellular Signalling 24, no. 1 (January 2012): 9–16. http://dx.doi.org/10.1016/j.cellsig.2011.08.009.

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15

Yue, H.-Y., C. Yin, J.-L. Hou, X. Zeng, Y.-X. Chen, W. Zhong, P.-F. Hu та ін. "Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats". Gut 59, № 2 (10 серпня 2009): 236–46. http://dx.doi.org/10.1136/gut.2008.174904.

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Background and aimsHepatocyte nuclear factor 4α (HNF4α) is a central transcriptional regulator of hepatocyte differentiation and function. The aim of this study was to evaluate the effect of HNF4α on attenuation of hepatic fibrosis.MethodsThe adenoviruses carrying HNF4α gene or containing siRNA targeting HNF4α were injected through tail vein on two distinct hepatic fibrosis models either induced by dimethylnitrosamine or by bile duct ligation in rats. Moreover, HNF4α, epithelial–mesenchymal transition (EMT)-related and fibrotic markers in hepatocytes, hepatic stellate cells (HSCs) and liver ti

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16

Bulla, G. A. "Hepatocyte nuclear factor-4 prevents silencing of hepatocyte nuclear factor-1 expression in hepatoma x fibroblast cell hybrids." Nucleic Acids Research 25, no. 12 (June 1, 1997): 2501–8. http://dx.doi.org/10.1093/nar/25.12.2501.

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17

ERICKSON, Roger H., James R. GUM, Craig D. LOTTERMAN, James W. HICKS, Roy S. LAI та Young S. KIM. "Regulation of the gene for human dipeptidyl peptidase IV by hepatocyte nuclear factor 1α". Biochemical Journal 338, № 1 (8 лютого 1999): 91–97. http://dx.doi.org/10.1042/bj3380091.

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Hepatocyte nuclear factor 1 was identified as the transcription factor binding to a 20 bp (-150 to -131) region of the gene for human dipeptidyl peptidase IV, which has been shown to be important for the expression of dipeptidyl peptidase IV in the human intestinal and hepatic epithelial cell lines Caco-2 and HepG2. Functional analysis of the hepatocyte nuclear factor 1 site was performed with two minimal dipeptidyl peptidase IV promoter constructs (-250 to -41, and -150 to -41) with and without a 3 bp mutation in the hepatocyte nuclear factor 1 sequence, and used in transient transfection exp

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18

Wu, Zhi-Tao, Dan Yao, Shu-Yi Ji, Xuan Ni, Yi-Meng Gao, Li-Jian Hui, and Guo-Yu Pan. "Optimized Hepatocyte-Like Cells with Functional Drug Transporters Directly-Reprogrammed from Mouse Fibroblasts and their Potential in Drug Disposition and Toxicology." Cellular Physiology and Biochemistry 38, no. 5 (2016): 1815–30. http://dx.doi.org/10.1159/000443120.

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Background/Aims: To develop a suitable hepatocyte-like cell model that could be a substitute for primary hepatocytes with essential transporter expression and functions. Induced hepatocyte-like (iHep) cells directly reprogrammed from mice fibroblast cells were fully characterized. Methods: Naïve iHep cells were transfected with nuclear hepatocyte factor 4 alpha (Hnf4α) and treated with selected small molecules. Sandwich cultured configuration was applied. The mRNA and protein expression of transporters were determined by Real Time PCR and confocal. The functional transporters were estimated by

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19

Liu, Hua, Hui Ren та Brett T. Spear. "The Mouse Alpha-Albumin (Afamin) Promoter Is Differentially Regulated by Hepatocyte Nuclear Factor 1α and Hepatocyte Nuclear Factor 1β". DNA and Cell Biology 30, № 3 (березень 2011): 137–47. http://dx.doi.org/10.1089/dna.2010.1097.

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20

Hadzopoulou-Cladaras, Margarita, Elena Kistanova, Catherine Evagelopoulou, Shengyou Zeng, Christos Cladaras, and John A. A. Ladias. "Functional Domains of the Nuclear Receptor Hepatocyte Nuclear Factor 4." Journal of Biological Chemistry 272, no. 1 (January 3, 1997): 539–50. http://dx.doi.org/10.1074/jbc.272.1.539.

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Nikolaidou-Neokosmidou, Varvara, Vassilis I. Zannis та Dimitris Kardassis. "Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor κB pathway". Biochemical Journal 398, № 3 (29 серпня 2006): 439–50. http://dx.doi.org/10.1042/bj20060169.

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HNF-4 (hepatocyte nuclear factor 4) is a key regulator of liver-specific gene expression in mammals. We have shown previously that the activity of the human APOC3 (apolipoprotein C-III) promoter is positively regulated by the anti-inflammatory cytokine TGFβ (transforming growth factor β) and its effectors Smad3 (similar to mothers against decapentaplegic 3) and Smad4 proteins via physical and functional interactions between Smads and HNF-4. We now show that the pro-inflammatory cytokine TNFα (tumour necrosis factor α) antagonizes TGFβ for the regulation of APOC3 gene expression in hepatocytes.

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22

Ning, Bei-Fang, Jin Ding, Jiao Liu, Chuan Yin, Wen-Ping Xu, Wen-Ming Cong, Qing Zhang та ін. "Hepatocyte nuclear factor 4α-nuclear factor-κB feedback circuit modulates liver cancer progression". Hepatology 60, № 5 (27 червня 2014): 1607–19. http://dx.doi.org/10.1002/hep.27177.

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23

Bonzo, Jessica A., Christina H. Ferry, Tsutomu Matsubara, Jung-Hwan Kim та Frank J. Gonzalez. "Suppression of Hepatocyte Proliferation by Hepatocyte Nuclear Factor 4α in Adult Mice". Journal of Biological Chemistry 287, № 10 (12 січня 2012): 7345–56. http://dx.doi.org/10.1074/jbc.m111.334599.

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Gonzalez, Frank J. "Regulation of Hepatocyte Nuclear Factor 4α-mediated Transcription". Drug Metabolism and Pharmacokinetics 23, № 1 (2008): 2–7. http://dx.doi.org/10.2133/dmpk.23.2.

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25

Massa, F., S. Garbay, R. Bouvier, Y. Sugitani, T. Noda, M. C. Gubler, L. Heidet, M. Pontoglio, and E. Fischer. "Hepatocyte nuclear factor 1 controls nephron tubular development." Development 140, no. 4 (January 29, 2013): 886–96. http://dx.doi.org/10.1242/dev.086546.

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de Boussac, Hugues, Marcin Ratajewski, Iwona Sachrajda, Gabriella Köblös, Attila Tordai, Lukasz Pulaski, László Buday, András Váradi та Tamás Arányi. "The ERK1/2-Hepatocyte Nuclear Factor 4α Axis Regulates HumanABCC6Gene Expression in Hepatocytes". Journal of Biological Chemistry 285, № 30 (12 травня 2010): 22800–22808. http://dx.doi.org/10.1074/jbc.m110.105593.

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Rausa, Francisco M., Yongjun Tan, Heping Zhou, Kyung W. Yoo, Donna Beer Stolz, Simon C. Watkins, Roberta R. Franks, Terry G. Unterman та Robert H. Costa. "Elevated Levels of Hepatocyte Nuclear Factor 3β in Mouse Hepatocytes Influence Expression of Genes Involved in Bile Acid and Glucose Homeostasis". Molecular and Cellular Biology 20, № 21 (1 листопада 2000): 8264–82. http://dx.doi.org/10.1128/mcb.20.21.8264-8282.2000.

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ABSTRACT The winged helix transcription factor, hepatocyte nuclear factor-3β (HNF-3β), mediates the hepatocyte-specific transcription of numerous genes important for liver function. However, the in vivo role of HNF-3β in regulating these genes remains unknown because homozygous null HNF3β mouse embryos die in utero prior to liver formation. In order to examine the regulatory function of HNF-3β, we created transgenic mice in which the −3-kb transthyretin promoter functions to increase hepatocyte expression of the rat HNF-3β protein. Postnatal transgenic mice exhibit growth retardation, depletio

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28

Ninomiya, Toshiaki, Hayashi Yoshitake, Saijoh Kiyofumi, Ohta Kyosuke, Yoon Seitetsu, Nakabayashi Hidekazu, Tamaoki Taiki, Kasuga Masato, and Itoh Hiroshi. "Expression ratio of hepatocyte nuclear factor-1 to variant hepatocyte nuclear factor-1 in differentiation of hepatocellular carcinoma and hepatoblastoma." Journal of Hepatology 25, no. 4 (October 1996): 445–53. http://dx.doi.org/10.1016/s0168-8278(96)80203-0.

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Guo, Hongtao, Chengjiang Gao, Zhiyong Mi, Philip Y. Wai та Paul C. Kuo. "Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4α transcriptional activity". Biochemical Journal 394, № 2 (10 лютого 2006): 379–87. http://dx.doi.org/10.1042/bj20051730.

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In IL-1β (interleukin 1β)-stimulated rat hepatocytes exposed to superoxide, we have previously identified an IRX (inflammatory redox)-sensitive DR1 [direct repeat of RG(G/T)TCA with one base spacing] cis-acting activator element (nt –1327 to –1315) in the iNOS (inducible nitric oxide synthase) promoter: AGGTCAGGGGACA. The corresponding transcription factor was identified to be HNF4α (hepatocyte nuclear factor-4α). HNF4α DNA binding activity and transactivation potential are tightly regulated by its state of phosphorylation. However, the functional consequences of IRX-mediated post-translationa

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Walesky, Chad, Sumedha Gunewardena, Ernest F. Terwilliger, Genea Edwards, Prachi Borude та Udayan Apte. "Hepatocyte-specific deletion of hepatocyte nuclear factor-4α in adult mice results in increased hepatocyte proliferation". American Journal of Physiology-Gastrointestinal and Liver Physiology 304, № 1 (1 січня 2013): G26—G37. http://dx.doi.org/10.1152/ajpgi.00064.2012.

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Hepatocyte nuclear factor-4α (HNF4α) is known as the master regulator of hepatocyte differentiation. Recent studies indicate that HNF4α may inhibit hepatocyte proliferation via mechanisms that have yet to be identified. Using a HNF4α knockdown mouse model based on delivery of inducible Cre recombinase via an adeno-associated virus 8 viral vector, we investigated the role of HNF4α in the regulation of hepatocyte proliferation. Hepatocyte-specific deletion of HNF4α resulted in increased hepatocyte proliferation. Global gene expression analysis showed that a majority of the downregulated genes we

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31

Courtois, G., S. Baumhueter, and G. R. Crabtree. "Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters." Proceedings of the National Academy of Sciences 85, no. 21 (November 1, 1988): 7937–41. http://dx.doi.org/10.1073/pnas.85.21.7937.

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Hayhurst, Graham P., Ying-Hue Lee, Gilles Lambert, Jerrold M. Ward та Frank J. Gonzalez. "Hepatocyte Nuclear Factor 4α (Nuclear Receptor 2A1) Is Essential for Maintenance of Hepatic Gene Expression and Lipid Homeostasis". Molecular and Cellular Biology 21, № 4 (15 лютого 2001): 1393–403. http://dx.doi.org/10.1128/mcb.21.4.1393-1403.2001.

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ABSTRACT The numerous functions of the liver are controlled primarily at the transcriptional level by the concerted actions of a limited number of hepatocyte-enriched transcription factors (hepatocyte nuclear factor 1α [HNF1α], -1β, -3α, -3β, -3γ, -4α, and -6 and members of the c/ebp family). Of these, only HNF4α (nuclear receptor 2A1) and HNF1α appear to be correlated with the differentiated phenotype of cultured hepatoma cells. HNF1α-null mice are viable, indicating that this factor is not an absolute requirement for the formation of an active hepatic parenchyma. In contrast, HNF4α-null mice

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Rawat, Siddhartha, and Michael J. Bouchard. "The Hepatitis B Virus (HBV) HBx Protein Activates AKT To Simultaneously Regulate HBV Replication and Hepatocyte Survival." Journal of Virology 89, no. 2 (October 29, 2014): 999–1012. http://dx.doi.org/10.1128/jvi.02440-14.

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ABSTRACTChronic infection with hepatitis B virus (HBV) is a risk factor for developing liver diseases such as hepatocellular carcinoma (HCC). HBx is a multifunctional protein encoded by the HBV genome; HBx stimulates HBV replication and is thought to play an important role in the development of HBV-associated HCC. HBx can activate the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway in some cell lines; however, whether HBx regulates PI3K/AKT signaling in normal hepatocytes has not been evaluated. In studies described here, we assessed HBx activation of PI3K/AKT signaling in anex vivo

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Drewes, Thorsten, Annette Clairmont, Ludger Klein-Hitpass, and Gerhart U. Ryffel. "Estrogen-Inducible Derivatives of Hepatocyte Nuclear Factor-4, Hepatocyte Nuclear Factor-3 and Liver Factor B1 are Differently Affected by Pure and Partial Antiestrogens." European Journal of Biochemistry 225, no. 1 (October 1994): 441–48. http://dx.doi.org/10.1111/j.1432-1033.1994.00441.x.

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Chou, Ho, Lai, Chen, Wu, Shun, Wen, and Lai. "B-Cell Activating Factor Enhances Hepatocyte-Driven Angiogenesis via B-Cell CLL/Lymphoma 10/Nuclear Factor-KappaB Signaling during Liver Regeneration." International Journal of Molecular Sciences 20, no. 20 (October 10, 2019): 5022. http://dx.doi.org/10.3390/ijms20205022.

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B-cell activating factor (BAFF) is found to be associated with the histological severity of nonalcoholic steatohepatitis (NASH). BAFF was also found to have a protective role in hepatic steatosis via down regulating the expression of steatogenesis genes and enhancing steatosis in hepatocytes through BAFF-R. However, the roles of BAFF during liver regeneration are not well defined. In this study, C57/B6 mice with 70% partial hepatectomy were used as a liver regeneration model. BAFF expression was determined by enzyme immunoassay, and anti-BAFF-neutralizing antibodies were administered to confir

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Cheng, Chun-Chia, Wan-Yu Yang, Ming-Chen Hsiao, Kuan-Hao Lin, Hao-Wei Lee, and Chiou-Hwa Yuh. "Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis." Biomolecules 10, no. 6 (June 12, 2020): 898. http://dx.doi.org/10.3390/biom10060898.

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Oligo-fucoidan, a sulfated polysaccharide extracted from brown seaweed, exhibits anti-inflammatory and anti-tumor effects. However, the knowledge concerning the detailed mechanism of oligo-fucoidan on liver cells is obscure. In this study, we investigate the effect of oligo-fucoidan in normal hepatocytes by transcriptomic analysis. Using an oligo-fucoidan oral gavage in wild-type adult zebrafish, we find that oligo-fucoidan pretreatment enhances the immune system and anti-viral genes in hepatocytes. Oligo-fucoidan pretreatment also decreases the expression of lipogenic enzymes and liver fibros

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Naiki, Takafumi, Masahito Nagaki, Takahiko Asano, Takayuki Kimata та Hisataka Moriwaki. "Adenovirus-mediated hepatocyte nuclear factor-4α overexpression maintains liver phenotype in cultured rat hepatocytes". Biochemical and Biophysical Research Communications 335, № 2 (вересень 2005): 496–500. http://dx.doi.org/10.1016/j.bbrc.2005.07.102.

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MACHIDA, Tomohisa, Masanori YASUDA, Michio SIMIZU, Norihide MOCHIZUKI, Kenji KAWAI, Hitoshi ITOH, Hiroshi KAJIWARA, Naoya NAKAMURA, and Yoshiyuki OSAMURA. "Immunocytochemical hepatocyte nuclear factor-1.BETA. expression in effusions." Journal of the Japanese Society of Clinical Cytology 49, no. 4 (2010): 242–47. http://dx.doi.org/10.5795/jjscc.49.242.

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Bellanné-Chantelot, Christine, Dominique Chauveau, Jean-François Gautier, Danièle Dubois-Laforgue, Séverine Clauin, Sandrine Beaufils, Jean-Marie Wilhelm та ін. "Clinical Spectrum Associated with Hepatocyte Nuclear Factor-1β Mutations". Annals of Internal Medicine 140, № 7 (6 квітня 2004): 510. http://dx.doi.org/10.7326/0003-4819-140-7-200404060-00009.

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Singh, Puja, Shu-Ping Tung, Eun Hee Han, In-Kyu Lee та Young-In Chi. "Dimerization defective MODY mutations of hepatocyte nuclear factor 4α". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 814 (березень 2019): 1–6. http://dx.doi.org/10.1016/j.mrfmmm.2019.01.002.

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Taraviras, Stavros, Gunther SchuTz, and Gavin Kelsey. "Generation of Inhibitory Mutants of Hepatocyte Nuclear Factor 4." European Journal of Biochemistry 244, no. 3 (March 15, 1997): 883–89. http://dx.doi.org/10.1111/j.1432-1033.1997.00883.x.

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Antkowiak, Mark, та Richard M. Green. "Telomeres, p53, Hepatocyte Nuclear Factor 4α, and Liver Disease". Hepatology 72, № 4 (жовтень 2020): 1166–68. http://dx.doi.org/10.1002/hep.31454.

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Kanazawa, T., A. Konno, Y. Hashimoto та Y. Kon. "Expression of Hepatocyte Nuclear Factor 4α in Developing Mice". Anatomia, Histologia, Embryologia 38, № 1 (лютий 2009): 34–41. http://dx.doi.org/10.1111/j.1439-0264.2008.00889.x.

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Lazarevich, N. L., and D. V. Alpern. "Hepatocyte nuclear factor 4 in epithelial development and carcinogenesis." Molecular Biology 42, no. 5 (October 2008): 699–709. http://dx.doi.org/10.1134/s0026893308050075.

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Green, Janelle, Dorit Naot, and Garth Cooper. "Hepatocyte nuclear factor 1 negatively regulates amylin gene expression." Biochemical and Biophysical Research Communications 310, no. 2 (October 2003): 464–69. http://dx.doi.org/10.1016/j.bbrc.2003.09.046.

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Yokoyama, Atsushi, Shogo Katsura, Ryo Ito, Waka Hashiba, Hiroki Sekine, Ryoji Fujiki та Shigeaki Kato. "Multiple post-translational modifications in hepatocyte nuclear factor 4α". Biochemical and Biophysical Research Communications 410, № 4 (липень 2011): 749–53. http://dx.doi.org/10.1016/j.bbrc.2011.06.033.

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Cao, Henian, та Robert A. Hegele. "Human hepatocyte nuclear factor-1β (HNF1B) 1968A/G polymorphism". Journal of Human Genetics 45, № 2 (березень 2000): 98–99. http://dx.doi.org/10.1007/s100380050021.

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Chandra, Shubhra, Srilakshmi Srinivasan, and Jyotsna Batra. "Hepatocyte nuclear factor 1 beta: A perspective in cancer." Cancer Medicine 10, no. 5 (February 13, 2021): 1791–804. http://dx.doi.org/10.1002/cam4.3676.

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Liu, Hailing, Brett E. Jones, Cynthia Bradham та Mark J. Czaja. "Increased cytochrome P-450 2E1 expression sensitizes hepatocytes to c-Jun-mediated cell death from TNF-α". American Journal of Physiology-Gastrointestinal and Liver Physiology 282, № 2 (1 лютого 2002): G257—G266. http://dx.doi.org/10.1152/ajpgi.00304.2001.

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The mechanisms underlying hepatocyte sensitization to tumor necrosis factor-α (TNF-α)-mediated cell death remain unclear. Increases in hepatocellular oxidant stress such as those that occur with hepatic overexpression of cytochrome P-450 2E1 (CYP2E1) may promote TNF-α death. TNF-α treatment of hepatocyte cell lines with differential CYP2E1 expression demonstrated that overexpression of CYP2E1 converted the hepatocyte TNF-α response from proliferation to apoptotic and necrotic cell death. Death occurred despite the presence of increased levels of nuclear factor-κB transcriptional activity and w

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Bingle, C. D., B. P. Hackett, M. Moxley, W. Longmore та J. D. Gitlin. "Role of hepatocyte nuclear factor-3α and hepatocyte nuclear factor-3β in Clara cell secretory protein gene expression in the bronchiolar epithelium". Biochemical Journal 308, № 1 (15 травня 1995): 197–202. http://dx.doi.org/10.1042/bj3080197.

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The 5′ flanking region of the Clara cell secretory protein (CCSP) gene contains two cis-acting elements which bind hepatocyte nuclear factor (HNF)-3 alpha and HNF-3 beta in vitro. To determine the role of these proteins in mediating CCSP gene expression in the bronchiolar epithelium, chimeric CCSP-reporter gene constructs containing various regions of the CCSP 5′ flanking region were co-transfected into H-441 cells with HNF-3 alpha or HNF-3 beta expression plasmids. These studies indicate that each of these transcription factors positively regulates CCSP gene expression and revealed that CCSP

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