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Rozprawy doktorskie na temat „HepG2 cells”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

呂可欣 and Ho-yan Lui. "Effects of lipoic acid on oxidant-induced cytotoxicity in HepG2 cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31969768.

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Lui, Ho-yan. "Effects of lipoic acid on oxidant-induced cytotoxicity in HepG2 cells." Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2203240X.

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Vahdati-Mashhadian, Nasser. "Regulation of CYP3A gene expression in human HepG2 hepatoma cells." Thesis, University of Surrey, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364817.

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Colton, Heidi Muth. "Dissecting Mechanisms of Toxicity in HepG2 Cells Using Gene Expression Analysis." NCSU, 2002. http://www.lib.ncsu.edu/theses/available/etd-09132002-161850/.

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Reduction/oxidation (redox) balance is a critical component of cell viability. When oxidants reach levels that overcome the ability of antioxidants to eliminate them, it results in damage to cellular macromolecules. The damage to DNA, lipids and protein initiates a cascade of physiological events in response to the oxidative stress. Researchers have been studying these cellular responses by analyzing gene expression and protein activity for many years. Recently, new technologies have emerged that allow scientists to analyze the differential expression of extremely large sets of genes in respon

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Etwebi, Zienab. "Magnesium Regulation of Glucose and Fatty Acid Metabolism in HEPG2 Cells." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307564164.

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Wang, Hui. "Molecular mechanisms of oridonin-induced cytotoxicity and apoptosis in HepG2 cells." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1162.

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Syed, Noor Afshan. "Regulation of glycogen synthase and glycogen phosphorylase by insulin in HepG2 cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ63926.pdf.

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Portolesi, Roxanne, and roxanne portolesi@flinders edu au. "Fatty acid metabolism in HepG2 cells: Limitations in the accumulation of docosahexaenoic acid in cell membranes." Flinders University. Medicine, 2007. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20070802.103146.

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The current dietary recommendations for optimal health are designed to increase our intake of two bioactive omega-3 (n-3) fatty acids, eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), abundant naturally in fatty fish such as salmon. Health authorities recommend that the general population consume two to three fatty fish meals per week (1) for optimal health and for the prevention of cardiovascular disease. However, some modern Western societies consume only modest amounts of fish and seafood (2;3). Land based vegetable oils may provide an alternative to meet the

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Morton, Latarchal D. "Ceramide stimulates 3 -methylcholanthrene’s ability to induce cytochrome (cyp1a1) p450 in hepg2 cells." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2005. http://digitalcommons.auctr.edu/dissertations/3648.

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This study showed that dihydroceramide and ceramide increased the expression of cytochrome (CYP) P450 when HepG2 cells were exposed to 3-methylcholanthrene (MC). Cytochrome P450s are a highly diversified set of heme proteins responsible for drug metabolism, blood homeostasis, cholesterol biosynthesis, and steriodogenesis. CYP1A1, the first P450 isoform to be named, is responsible for the metabolism and biotransformation of polycyclic aromatic hydrocarbons (PAH). 3-methylcholanthrene, an extremely hazardous PAH, has been shown to induce the CYP1A1 gene through the aryl hydrocarbon receptor (AhR

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10

To, Wing Shu. "Effect of cellular redox and energy states on benzo[a]pyrene induced modes of death in the hepa and the HepG2 cell lines." HKBU Institutional Repository, 2010. http://repository.hkbu.edu.hk/etd_ra/1173.

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Andreou, Efrosini Roseann. "Analysis of CYP7A1 gene regulation in HepG2 cells by reverse-transcriptase polymerase chain reaction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29317.pdf.

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Ibbitson, Deanna. "Effects of zinc on retinoic acid-induced growth inhibition in human hepatocarcinoma HepG2 cells." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/40664.

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Retinoic acid (RA), a bioactive metabolite of vitamin A, inhibits growth in a variety of cancer cells including liver cancer. It is thought that this function of RA is achieved by modulating gene expression through complexing with retinoic acid receptors (RARs) and retinoid X receptors (RXRs), two groups of zinc-finger proteins. Zinc deficiency has been shown to affect gene expression and to impair DNA binding ability of zinc-finger proteins. The hypotheses of my thesis research were: 1) sufficient cellular zinc level is important for the effectiveness of RA-induced growth inhibition in hepa

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13

Peters, Demia E. "Complex sphingolipid involvement in the expression of CYP1A1 activity in 3-methylcholanthrene-exposed HEPG2 cells." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2001. http://digitalcommons.auctr.edu/dissertations/2482.

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Polycyclic aromatic hydrocarbons (PAHs), complex organic molecules that are the by-products of carbon-based fuel combustion, are carcinogenic upon biotransformation in the body. Cytochrome P450 1A1 (CYP1A1) is part of the enzyme system primarily responsible for the metabolism and biotransformation of PAHs in humans. In HepG2 cells (a human hepatoma cell line), it has been established previously in this laboratory that 3-methylcholanthrene (MC), a PAH, induces CYP1A1 activity 20 to 30 fold over control values. Also in those studies, MC’s ability to induce this activity was significantly reduced

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14

Davies, Emily Claire. "Green tea extract and its metabolites induce biochemical changes linked to hepatotoxicity in HepG2 cells." Thesis, Davies, Emily Claire (2019) Green tea extract and its metabolites induce biochemical changes linked to hepatotoxicity in HepG2 cells. Honours thesis, Murdoch University, 2019. https://researchrepository.murdoch.edu.au/id/eprint/54595/.

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Green tea has been consumed for thousands of years and its concentrated extract is now a popular herbal supplement frequently consumed in isolation or as part of a multi-ingredient product. Green tea extract (GTE) is commonly used for its wide range of purported health benefits and, as with most herbal supplements, its sale on the Australian market is regulated by the Therapeutic Goods Administration without requiring pre-market safety or efficacy analysis. Unfortunately, GTE has been implicated in over 50 cases of liver damage in the last 20 years, a number of which resulted in transplantatio

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15

Oliveira, Rita de Cássia Silva de. "Avaliação da citotoxicidade, genotoxicidade e mutagenicidade da mandioca (Manihot esculenta Crantz) em célula tumoral HepG2." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-27092012-141240/.

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O fator alimentar pode ser considerado um promotor tumorigênico responsável pela etiologia do câncer gástrico no estado do Pará. A mandioca (Manihot esculenta Crantz) é uma das muitas espécies da Amazônia consumida de modo indiscriminado pelos habitantes da região norte. O cianeto, seu principal componente tóxico, pode ser liberado durante o processamento da mandioca por meio da hidrólise do glicosídeo cianogênico linamarina. No organismo, o cianeto bloqueia a cadeia de transporte de elétrons inibindo a respiração celular e, provocando, entre outras coisas, a produção de radicais livres que po

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Lamy, Evelyn [Verfasser]. "MTBITC-induced apoptosis and cell cycle arrest of human hepatoma (HepG2) cells : a link between p53 and human telomerase? / Evelyn Lamy." Gießen : Universitätsbibliothek, 2015. http://d-nb.info/1068922540/34.

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Dorta, Daniel Junqueira. "Efeitos citoprotetor e/ou citotóxico dos flavonóides: estudo estrutura-atividade envolvendo mecanismos mitocondriais, com ênfase na apoptose." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60134/tde-17102007-160656/.

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Realizou-se um estudo estrutura-atividade sobre os efeitos citoprotetor/citotóxico de 5 flavonóides envolvendo processos mitocondriais, com ênfase na apoptose. Nossos resultados mostram que a dupla ligação na posição 2-3 / grupos 3-OH em conjugação com a função 4-oxo no anel C da estrutura dos flavonóides parece favorecer a interação destes compostos com a membrana mitocondrial, diminuindo a sua fluidez, e tanto inibindo a cadeia respiratória das mitocôndrias, quanto causando desacoplamento. Por outro lado, a estrutura o-di-OH no anel B parece favorecer a inibição da cadeia respiratória, sendo

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18

Morrison, Natasha Louise. "Characterising biochemical changes to hepatocellular carcinoma (HepG2) cells upon exposure to green tea extract using untargeted metabolomics." Thesis, Morrison, Natasha Louise (2019) Characterising biochemical changes to hepatocellular carcinoma (HepG2) cells upon exposure to green tea extract using untargeted metabolomics. Honours thesis, Murdoch University, 2019. https://researchrepository.murdoch.edu.au/id/eprint/53997/.

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Complementary and alternative medicines (CAMs) have become the preferred medicine for many in replacement of conventional medicines due to cultural or financial reasons. Herbal CAMS, in particular, have become a popular choice of medicine for their purported health benefits. Green tea extract (GTE) contains the major catechins epigallocatechin-3-gallate, epicatechin gallate, epigallocatechin and epicatechin, all of which vary across different GTE products and have become the focus on research into its purported health benefits. However, there have been cases of GTE-induced hepatotoxicity, for

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Chen, Wen Xin, and 陳文馨. "Cell death pathway in HepG2 cells infected with Klebsiella pneumoniae." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/74869141036163957800.

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碩士<br>長庚大學<br>基礎醫學研究所<br>96<br>Severe liver abscess caused by Klebsiella pneumoniae (KP) has been observed recently in Taiwan, mostly in diabetic patients and through nosocomial infections. How the bacteria cause liver abscess is not clear. The aim of this study was to investigate the mechanism of cell death in KP-infected hepatocytes. Using a human hepatoma cell line, HepG2, as a model system, we studied the cell death pathway involved in HepG2 infected with liver abscess-causing KP (KP5). The cytotoxic effect of KP5 infected-HepG2 cells is time-and dose-dependent. KP5 induced cell cycle arre

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20

Wu, Yifei. "The effect of saturated and unsaturated fatty acids on HEPG2 cells and the trehalose protection of HEPG2 cells on palmitate induced toxicity." Diss., 2008.

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Thesis (M.S.)--Michigan State University. Dept. of Chemical Engineering and Material Science, 2008.<br>Title from PDF t.p. (viewed on July 29, 2009) Includes bibliographical references (p. 34-41). Also issued in print.

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Yang, Li-chia, and 楊禮嘉. "Electrophoresis of HepG2 Cells: Experimental and Theoretical Modeling." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/45539161524917820069.

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碩士<br>國立臺灣大學<br>化學工程學研究所<br>93<br>Electrophoresis, the movement of a charged entity as a response to an applied electric field, is a useful tool to gather information about the charged conditions on cell surface. The electrophoretic behavior of HepG2 cells is investigated in this study both experimentally and theoretically. Experimentally, Zetasizer3000 is used to determine the mobility of HepG2 cells. Effects of pH, ionic strength, and different kinds of divalent cations are examined. We can discuss the properties and the kinds of functional groups on the surface of HepG2 cells by electrophor

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Hua, Yi Syuan, and 滑翌軒. "G6PD Knockdown Enhances Inflammatory Responses in HepG2 cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/98949725840134162851.

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碩士<br>長庚大學<br>醫學生物技術暨檢驗學系<br>98<br>Glucos-6-phosphate dehydrogenase (G6PD) plays an important role in the generation of NADPH and maintains cellular redox homeostasis. Imbalanced redox status alters cellular physiology including cell proliferation, differentiation and inflammatory response. Since G6PD deficiency affects the innate cellular immune response and accelerates cellular senescence, we attempt to further elucidate the relationship between G6PD and inflammatory response. In this study, G6PD-scramble (Sc) and G6PD-knockdown (Gi) HepG2 cells were used as cellular model to determine the r

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Yang, Ya-Han, and 楊雅涵. "Generation of liver cancer stem cell-like cells from HepG2 derived induced pluripotent stem cell-like cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/m6vnb5.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>103<br>Recently, liver cancer (hepatocellular carcinoma) is the second most common malignant tumor among the top ten cancer death in Taiwan. Nevertheless, only about one to five patients could successfully undergo tumor removal by surgery and show good prognosis. In addition, the recurrence rate of liver cancer is high. Nowadays, recurrence is considered highly correlated with cancer stem cells (CSCs). At 2006, Professor Shinya Yamanaka found mouse adult fibroblast can be transfected by lentivirus with OCT4, SOX2, KLF4, C-MYC, and shTP53 and reprogramed into induced

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Wang, Huei-Rong, and 王惠蓉. "Effects of plant components on human hepatoma cell line HepG2 cells and vascular smooth muscle cells." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/73339534542527555515.

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碩士<br>國立臺灣大學<br>藥理學研究所<br>82<br>1.肝細胞增生( proliferation ) 是造成肝細胞癌( hepatocellular carcinoma ) 的主要原因之一。藥物作用4.5 小時，baicalein與 esculetin 皆可抑制 HepG2 細胞增生，且其作用程度類似。藥物作用 24 小時，以 baicalein 抑制效果最強， d-catechin 次之， esculetin 最弱o 在 HepG2 細胞，baicalein 之抗增生作用可能主要經由抑制 protein tyrosine kinase ; esculetin 的作用機轉可能是抑制 protein tyrosine kinase、protein kinase C，及促進 PGE2的合成。 2.血管平滑肌細胞的增生 (proliferation) 是造成粥狀動脈硬化 (atherosclerosis) 的主要原因之一。實驗首先比較九個 coumarins 藥物對血管平滑肌細胞增生的作用，結果以 escu

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chuen, Sung jia, and 宋佳純. "Benzidine Induces DNA Damage Signaling Pathways in HepG2 cells." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/59816481071738841330.

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碩士<br>高雄師範大學<br>生物科技系<br>98<br>Benzidine, a known human carcinogen, induces DNA damage in human hepatoma G2 cells (HepG2 cells) via the analysis of comet assay. A DNA damage signaling pathway of benzidine-induced DNA damage was determined. A PCR array composing of 84 genes belonging to three groups of DNA repair, cell cycle arrest, and apoptosis were tested for the differential genes in HepG2 cells treated with vs without 200μM benzidine after 24h incubation. Results showed that 24 genes expression levels were unregulated over 2 fold (p&lt;0.05) in 200µM benzidine- treated cells. These gen

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Hwang, Yu-Chun, and 黃宇君. "Squamocin causes cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/50804116840024360384.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>97<br>Malignant neoplasm has become the leading cause of death in Taiwan. According to stastistic data from Department of Health, hepatocellular carcinoma (HCC) is the second common cancer in Taiwan. At present, systemic therapies including chemotherapy and molecular targeted therapy can not effectively treat this malignancy because of resistance to drugs and descent of tolerance caused by liver dysfunction. Therefore, it is an emergent task to find new drug candidates for treating HCC. Natural products represent a rich source of new chemical compounds for developin

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Shan, Han-i., and 孫菡儀. "Molecular mechanism of human hepatoma cell line HepG2 cells growth arrest by esculetin." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/81460098403338068236.

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碩士<br>中山醫學院<br>生物化學研究所<br>89<br>Abstract Esculetin is a phenolic compound of coumarin derivative containing in many plants such as Atemisiae capillaris Flos ( Compositae ), leaves of Citrus limonia ( Rutaceae ), Digitalis purpurea L. ( Scropulariaceae ), Euphorbia lathyris L. ( Eupho-biaceae ), Atropa belladonna ( Solanaceae ), Datura Stramonium L., Hyoscyamus niger L. In the past decade esculetin has been reported to have antiplatelet, antioxdant, anti-inflammatory and anticarcinogenic effects. Recently, it has also been reported to decrease the survival of human leukemia and breas

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Tuan, Yen-Fan, and 段姸帆. "3,3’- Dichlorobenzidine-induced cytotoxicity via MAPK pathways in HepG2 cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/58496877698433205043.

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碩士<br>國立高雄師範大學<br>生物科學研究所<br>100<br>Epidemiological studies have suggested a relationship between long term exposure of 3,3'-Dichlorobenzidine (DCB) among dyeing industry workers and the increased risks of cancer development, especially bladder cancer and lymphohematopoietic cancer. Our previous study had demonstrated that DCB leaded to genotoxicity by causing DNA breakage in human lymphocytes. In this study, the signaling pathways involved in DCB-induced DNA damage and cytotoxicity in human liver cancer cells (HepG2) were investigated. We found that DCB could increase the expression of-H2AX

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Chan, Yu-Ju, and 詹育儒. "Curcuma Oil Induces a ROS-Dependent Apoptotic Cell Death in Human Hepatoma HepG2 Cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/73182723709217910645.

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碩士<br>國立暨南國際大學<br>生物醫學科技研究所<br>97<br>The hepatocellular carcinoma (HCC) has high prevalence rates in the world, especially in Asia. Recently, it is the leading cause of death in Taiwan. Currently, no effective therapy is available for the treatment of HCC patients. Thus, it is crucially important to develop effectively therapeutic strategies for the management of HCC. Curcuma longa L., which belongs to the Zingiberaceae family, has been used as a folk medicine in South-Eastern Asia. The main constituents of Curcuma longa L. are curcuma oil and curcumin. Curcumin has been reported as a potentia

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Ho, Pei-Tzu, and 何珮慈. "Cell growth inhibitory effects of pterostilbene and 3′- hydroxypterostilbene in human hepatoma HepG2 cells." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/8epwxp.

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PENG, YA-JYUN, and 彭雅君. "Investigation of Huanglian (Rhizoma Coptidis) extract Induced Cell Apoptosis in Human Hepatoblastoma HepG2 Cells." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/nqhx58.

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碩士<br>輔英科技大學<br>生物科技系碩士班<br>107<br>Huanglian (Rhizoma coptidis), a widely used traditional Chinese medicine relatively safe with no adverse effects from long term use, has been used for the treatment of heat-clearing and detoxifying. Berberine and Palmatine, the yellow isoquinoline alkaloid extracted from Huanglian, have a wide range of biological and pharmacological activities that include inhibition of DNA, anti-proliferative and protein synthesis, arrest of cell cycle progression and pro-apoptotic effects on cancer cells. In the study we investigated the cytotoxic effects of Beberine and Pa

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"Effect of antisense oligonucleotide against glucose transporter on human hepatocellular carcinoma HepG2 and its multi-drug resistant R-HepG2 cells." 2001. http://library.cuhk.edu.hk/record=b5890822.

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Lam Mei Wah.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2001.<br>Includes bibliographical references (leaves 172-181).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>論文撮要 --- p.iv<br>Acknowledgement --- p.vii<br>Table of contents --- p.viii<br>List of tables --- p.xi<br>List of figures --- p.xii<br>Abbreviations --- p.xvii<br>Chapter Chapter 1: --- Introduction --- p.1<br>Chapter 1.1 --- The facilitative glucose transporter family --- p.2<br>Chapter 1.2 --- Overexpression of glucose transporters in tumor cells --- p.5<br>Chapter 1.3 --- Antisense strategy ---

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"Roles of mitochondria in the multidrug resistance in R-HepG2 cells." 2002. http://library.cuhk.edu.hk/record=b6073488.

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by Li Yanchun.<br>"August 2000."<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2002.<br>Includes bibliographical references (p. 193-213).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Mode of access: World Wide Web.

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"Inducibility and overexpression studies of antiquitin in HEK293 and HepG2 cells." 2005. http://library.cuhk.edu.hk/record=b5896393.

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Wong Wei-yan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 221-242).<br>Abstracts in English and Chinese.<br>Thesis committee --- p.i<br>Declaration --- p.ii<br>Acknowledgements --- p.iii<br>Abstract in Chinese --- p.iv<br>Abstract in English --- p.vi<br>List of abbreviations --- p.viii<br>List of figures --- p.xi<br>List of tables --- p.xv<br>Content: --- p.xvi<br>General introduction --- p.1<br>Aldehyde dehydrogenase superfamily --- p.3<br>Background of antiquitin --- p.5<br>Plant antiqutins (ALDH7B) --- p.5<br>Animal

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Allen, Katherine. "The effects of troglitazone and PMA on AMPK in HepG2 cells." Thesis, 2016. https://hdl.handle.net/2144/16783.

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Type 2 diabetes, as well as other metabolic diseases, is an increasing global health concern and many of the mechanisms of both the disease and its current drug treatments have not been fully described. It has been shown that the anti-diabetic class of drugs, the thiazolidinediones, work via both a known PPARγ-dependent, and a lesser known PPARγ-independent mechanism of action. This PPARγ-independent mechanism likely involves the metabolic regulatory molecule AMPK, which has a newly elucidated inhibitory site of phosphorylation at Ser485/Ser491. In this study we sought to determine if the thia

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Hsu, Chih-Wen, and 徐智文. "A Mechanical Study on the anti-attachment of HepG2 Tumor Cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/89385675631049495410.

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碩士<br>淡江大學<br>機械與機電工程學系碩士班<br>99<br>For metastasis of tumor cell invade into the circulatory system, it have to do with tumor-cell of detachment and attachment. This work presents the first part of a new framework for preventing the tumor-cell of carcinoma in situ transition from one organ to others. Using an ECIS (electric cell-substrate impedance sensing) chip coated with glutaraldehyde (GA)-crosslinked gelatin patterns suitable for cell attachment, the author monitor the cell adhesion situation not only by optical microscope but also by electrical means. This cell-culture experiment with 1-

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Shiu, Shin-Mau, and 許新茂. "Monacolin K enhances lipolysis through SIRT1/AMPK pathway in HepG2 cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/37077140136760129745.

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碩士<br>中臺科技大學<br>醫學檢驗生物技術系碩士班<br>100<br>Monacolin K, originally isolated from Monascus spp. as the secondary metabolite, has been previously demonstrated to reduce the synthesis of cholesterol in association with a decrease in low density lipoprotein (LDL) and an increase in high density lipoprotein (HDL) by inhibiting the enzymatic activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. In this study, monacolin K was found to increase the protein level of SIRT1 and the phosphorylation level of AMP-activated protein kinase (AMPK) in HepG2 cells, and the effects have been reported

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Yi-Ling and 陳怡伶. "Studies on the Toxic Effects of 3,3’-Dichlorobenzidine in HepG2 Cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/53571676125383662066.

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碩士<br>高雄師範大學<br>生物科技系<br>97<br>3,3’-dichlorobenzidine (DCB) is a benzidine-based azo dye. This study investigated the DCB of the toxic effects of Hep G2 cells. In MTT assay, results showed that DCB can induce DNA damage in HepG2 cells with the manner of dose-dependent trend. The proteomics and flow cytometry were used for the toxic effect in cells-treated with 100µM of DCB. The use of flow cytometry in combination with Annexin V-FITC/PI staining showed that 100μM DCB can result in 40% of Hep G2 cells producing apoptosis. In addition, using of flow cytometry combined with DCFH-DA staining, we f

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Tung, Po-Yuan, and 董伯元. "Effects of acidic extracellular pH on Adherens Junctions of HepG2 cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/34233021523465313868.

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碩士<br>臺灣大學<br>解剖學暨生物細胞學研究所<br>95<br>An acidic extracellular pH (pHe) is a feature of the tumor microenvironment and increases tumor invasion. However, little attention has been paid to the role of adherens junctions (AJs) in acidic pHe-induced cell invasion. We hypothesized that an acidic pHe may increase cell migration by disruption of the AJ via modulation of cell-cell adhesion molecules. Our results showed that incubation of HepG2 cells in acidic medium (pH 6.6) induced a phenotypic change from tight cell clusters to dispersed cells with a flattened morphology and this change was accompanie

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Wang, Chun-Hui, та 王君蕙. "Effect of Mitochondrial Stress on HIF-1α Expression in HepG2 Cells". Thesis, 2007. http://ndltd.ncl.edu.tw/handle/64579080784053969725.

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碩士<br>國立陽明大學<br>藥理學研究所<br>95<br>Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus and influences many cellular activities under both normal and pathophysiological conditions. Nevertheless, little is known about the retrograde signaling in mammalian system. Many years ago, Dr. Warburg proposed a link between defects in mitochondrial physiology and tumorigenesis. After that, the relationship between mitochondria and cancer was further investigated. Recently, somatic mutations and reduced copy number of mitochondrial DNA (mtDNA) have been found in m

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Kang, Shih-Pei, та 康詩珮. "Study of Glycyrrhiza uralensis against NF-κB Activation in HepG2 Cells". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/02907314063135520957.

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碩士<br>國立陽明大學<br>傳統醫藥研究所<br>99<br>Liver fibrosis usually results from liver inflammation. When liver is damaged, hepatocytes live in an inflammatory microenvironment. Proinflammatory cytokine, TNF-α stimulates hepatocytes via NF-κB. This study was aimed to screen potential herbs against NF-κB activation in HepG2 cells. Human hepatoma cell lines were used to imitate human hepatocytes in this study. HepG2 cells were stimulated by TNF-α with or without herbs. NF-κB reporter gene assay was used to screen herbs against NF-κB transcription activity. Cell viability was measured by MTT assay. TNF-α-ind

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Lo, Hsin-Yi, and 羅欣宜. "Study On The Regulation Of Metabolism In HepG2 Cells By Astragalosides." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/65219895023490738429.

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碩士<br>國防醫學院<br>生物化學研究所<br>100<br>Astragalosides are major components of astragalus membranaceus and are attributed for most of its anti-diabetes pharmacological activities. Despite extensive studies, the mechanism of action of astragalosides remains to be clarified. In our previous studies, purified astragalosides AS4 and AA were shown to enhance glucose uptake in Caco-2 intestine cells. In addition, these compounds also enhanced energy production by significantly increasing the intracellular level of ATP in HepG2 hepatic cells. Liver plays a key role in the regulation of organism energy metab

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Chu, Ching-yu, and 朱靜郁. "Anti-angiogenesis of Ursolic acid and Oleanolic acid on HepG2 Cells." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/29354015805483657753.

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碩士<br>慈濟大學<br>生命科學系碩士班<br>99<br>Hepatocellular carcinoma (HCC) is one of the most malignant tumors with high rate of recurrence and metastasis. Angiogenesis is a very important process that mediates tumor growth and metastasis, and can be used as a therapeutic target among all the strategies for many cancers. Ursolic acid (UA) and its derivative oleanolic acid (OA), are two glycyrrhetinic acid related pentacyclic triterpenoids that we had found anti-tumor effects in HepG2 cells in previous studies. The aim of this study is to further investigate whether UA and OA have the inhibitory effect on

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Chen, Guei-Lan, and 陳貴蘭. "Study of the mechanism of iron chelatingagent-deferoxamine induced cell death in hepatoma HepG2 cells." Thesis, 2000. http://ndltd.ncl.edu.tw/handle/77775570818750334196.

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碩士<br>國立陽明大學<br>藥理學研究所<br>88<br>Iron is required for cell proliferation and excess iron may be involved in the development of hepatocellular carcinoma. In this study, the effects of deferoxamine (DFO), an iron chelator, in human hepatoma HepG2 cells was investigated. DFO treatment dose dependently reduced the viability and cell growth of HepG2 cells. Moreover, DFO treated cells showed morphological changes including an increase of cell volume as well as intracellular granules. Flow cytometric analyses showed that DFO treatment resulted in an increase of cells in G1-S phase and a decrease of ce

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Lii, Herng-Jiun, and 李恆君. "Part I Study of enhancement effect of Paclitaxel-induced apoptosis by Esculetin in HepG2 cells Part II Study of antiproliferation effect of Ixeris chinensis in HepG2 cells." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/45418413980626884260.

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碩士<br>中山醫學大學<br>生物化學研究所<br>91<br>Part I: Esculetin (EST) is a phenolic natural antioxidant of coumarin derivative. In modern times, there are more and more researches about the biological and biochemistry activity of Esculetin. Latest finding is Esculetin can inhibit the survival of human lukemia and breast cancer cells. However, the antiproliferation mechanism of Esculetin on cacer is not well understood. Palictaxel was extracted from the bark of Texus brevifolia in 1967 and was applied spreadly on the therapy of cancer. It’s a popular research trend about how to lower the toxicity on humanbo

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楊德群. "Studies of Ginsenosides on Glucose Absorption in Caco2 Cells and Intracelluar ATP Level in HepG2 Cells." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/02913673854393858953.

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碩士<br>國防醫學院<br>藥學研究所<br>92<br>Ginseng, the root of Panax ginseng, is a very old and well-known drug in traditional Chinese medicine used mainly to reinforce qi and invigorate the function of the spleen. Being interested in exploring of the mechanism of reinforcement qi of ginseng, the investigation of P. notoginseng, the same genus of ginseng, was undertaken in this study to prepare ginsenosides which were mainly active components of ginseng. The alcohol extract of the root of P. notoginseng was separated and purified by adsorbent resin, silica gel and reversed-phase chromatography

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陳琦斐. "Evaluate the Antiproliferative Effects of Perilla frutescens Extract on Human Hepatoma Cells (HepG2) and Differentiating Apoptotic Related Genes in the Extract Treated HepG2 Cells Using DNA Microarray Analysis." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/83113652167715450840.

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碩士<br>國立交通大學<br>生化工程研究所<br>91<br>Background: Hepatocellular carcinoma is one of the most common malignant tumors in oriental countries. However, effective drugs for treating this disease are still unavailable. Emerging evidence has demonstrated that many natural products isolated from plant sources possess antitumor properties. Interest in exploiting traditional medicines for prevention or treatment of cancer is increasing. In cancer treatment, the therapeutic goal is to trigger tumor-selective cell death. Apoptosis represents a universal and exquisitely efficient cellular suicide pathwa

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Chiou, Bin-Hao, and 邱炳豪. "MicroRNA regulation of DNA repair gene expression in4-aminobiphenyl-treated HepG2 cells." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/06983542721089265929.

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碩士<br>國立中央大學<br>生命科學系<br>103<br>The study goal was to evaluate the effects of 4-aminobiphenyl (4-ABP) on DNA damage based on the regulation of miRNAs to suppress some reducing DNA-repair proteins in human HepG2 cells. In this study, we used comet assay to determine that 4-ABP (0–300 M) induces DNA damage in HepG2 cells after 24 hours. DNA damage signaling pathway-based PCR arrays were used to investigate differential expressed genes response to 4-ABP treatment. In parallel, the miRNAs array was revealed that the expression of 27 miRNAs in 4-ABP-treated cells was at least 3-fold higher than th

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Liou, Tsuei-Ru, and 劉翠茹. "Detoxifying Enzymes Induction Effect of Methyl Gallate in Human HepG2/C3A cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/82204328791195210696.

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碩士<br>國立屏東科技大學<br>生物科技研究所<br>97<br>Detoxifying enzymes system protects the body against the potential harmful exposure to xenobiotics from the environment as well as certain endobiotics. Plant phenols contribute significant biological properties such as anti-inflammatory, antioxidant. Methyl gallate is the major phenol constituents of a lot of nature plant. It was reported that ROS as intracellular signaling molecules could activate of transcription factor NF-E2-related factor 2 (Nrf2) and bind to ARE sequences, which is leading to transcriptional activation of phase II enzymes including GCL a

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Silva, Ana Marta Ribeiro da. "Role of mitochondrial p66Shc in nefazodone-induced mitochondrial toxicity on HepG2 cells." Master's thesis, 2015. http://hdl.handle.net/10348/6943.

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Dissertação de Mestrado em Biologia<br>A Nefazodona (NEF) é um fármaco antidepressivo, usado durante um longo período no tratamento da depressão. Apesar da sua eficácia, este fármaco foi retirado do mercado devido ao aparecimento de diversos casos de lesão hepática em pacientes submetidos a tratamento com NEF. A via de sinalização celular que envolve a proteína p66Shc, e a sua fosforilação na serina 36 (Ser36) após estimulo de stress, foi anteriormente associada à produção de espécies reactivas de oxigénio e à ocorrência de morte celular. De acordo com esta hipótese, a proteína p66Shc é transl

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