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Rozprawy doktorskie na temat „HLA histocompatibility antigens”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 30 lipca 2024

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1

Talken, Beth L. "Assembly of the Lw¹⁶ and Ld class I MHC molecules." free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9720532.

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2

Pang, Ha Sang. "Identification of CD8+ T cell epitopes from HCA661 presented by HLA-A2 molecules /." View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202006%20PANG.

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3

葉德俊 and Tak-chun Timothy Yip. "Characterization of a monoclonal antibody reactive against major histocompatibility complex class II antigens." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B3123334X.

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Yip, Tak-chun Timothy. "Characterization of a monoclonal antibody reactive against major histocompatibility complex class II antigens /." [Hong Kong] : University of Hong Kong, 1992. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13478771.

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5

Hume, Clifford Robert. "Regulation of HLA class II expression in class II negative mutant B-cell lines /." Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=745028251&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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6

Halley, Lorna Louise. "The investigation of the HLA system and wheat gluten in determining risk of schizophrenia." Thesis, University of the Highlands and Islands, 2015. https://pure.uhi.ac.uk/portal/en/studentthesis/the-investigation-of-the-hla-system-and-wheat-gluten-in-determining-risk-of-schizophrenia(60acd449-c659-4743-9dbd-4392c0fc015a).html.

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Genome-wide association (GWA) studies confirmed that the HLA genes were strongly associated with schizophrenia but the HLA variants identified by GWA studies had a lower frequency in patients with schizophrenia than control subjects. The HLA molecules have function of presenting peptide antigens to T lymphocytes in order to initiate an immune response. Environmental factors such as infection and dietary proteins have been found to be associated with schizophrenia. This PhD program has thus focused on the following objectives: (1) identification of genetic variants for schizophrenia in the HLA

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7

Kosmoliaptsis, Vasilis. "Investigation into the immunogenicity of human leukocyte antigen mismatches in kidney transplantation." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609630.

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8

Schulte, Kathleen Q. "Mutagenized HLA DNA Constructs: Tools for Validating Molecular HLA Typing Methodologies." Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc500888/.

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This study describes the development and validation of mutagenized cloned DNA constructs, which correspond to the polymorphic regions of the class II region of the HLA complex. The constructs were used to verify the allelic specificity of primers and probes in polymerase chain reaction (PCR)-based HLA typing assays such as Sequence Specific Primers (SSP) and Sequence Specific Oligonucleotide Probes (SSOP). The constructs consisted of the entire polymorphic region of exon 2 of class II HLA allele sequences that included primer annealing sites or probe hybridization sites. An HLA allele sequence

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9

Yamamoto, Masaru. "Synthesis and oxidation studies of sulfur containing inhibitors for human leukocyte elastase : (2) synthesis of cyclic peptide analogs for tissue factor pathway inhibitor (TFPI) : Part 2 synthesis and evaluation of aziridinecarboxylic acid analogs as a new family of cysteine proteinase inhibitors." Diss., Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/25953.

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10

Chang, Yea-wen. "Application of molecular genetic techniques to the study of major histocompatibility complex class II allelic associations with insulin-dependent diabetes mellitus in Chinese /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18539919.

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11

Oudshoorn, Machteld. "Investigations into the complexity and polymorphism of HLA-D loci in South Africa." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/26581.

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The HLA complex is the most polymorphic genetic system known in man. The frequency of the HLA class II antigens have been well studied in Caucasoids but little data is available concerning HLA antigen frequencies in Negroes. In this thesis the class II antigens, excluding HLA-DP, were studied in South African (SA) Negroes (Xhosa), Cape Coloureds ( a group of mixed racial origin) and SA Caucasoids using serological, cellular ( HTC typing) and Southern blot techniques. The results obtained for the SA Negroes were compared with those previously found in Nigerians and American Negroes. Marked diff

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12

Bonfiglioli, Rubens. "Frequência dos alelos do HLA-B27 em pacientes brasileiroa com artrite psoriásica." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310633.

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Orientador: Manoel Barros Bértolo<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T11:36:12Z (GMT). No. of bitstreams: 1 Bonfiglioli_Rubens_D.pdf: 4535259 bytes, checksum: c162b3d3293837dabf58f540050f6b46 (MD5) Previous issue date: 2009<br>Resumo: Este estudo prospectivo analisou a epidemiologia, clínica e perfil genético de 102 pacientes brasileiros com Artrite Psoriásica. A associação do complexo maior de histocompatibilidade (MHC) de classe I, e os alelos do HLA-B27 com aquelas variáveis foram avaliados e comp

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13

Odeberg, Jenny. "Human cytomegalovirus immune evasion strategies /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-126-8.

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14

Patel, Kantibhai Motiram. "The association of the human leukocyte antigens alleles and type 2 diabetes mellitus among Mexican Americans." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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15

Wong, Hoi-hei Vera, and 王愷曦. "Isolation of human leukocyte antigen G/cytokeratin 7 positive fetal cells from transcervical samples for potential use in prenatal genetic diagnosis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/208587.

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There has been an increase in rates of chromosomal abnormalities in newborns as a result of reproductive aging. For the past decades, a lot of effort has been placed on identifying pregnancies at risk of genetic defects. Conventional prenatal genetic diagnosis is achieved by invasive procedures that have been associated with an increased risk of pregnancy loss. This has led the researchers to explore the use of non-/minimally invasive techniques for prenatal diagnosis. Trophoblasts are known to be shed from regressing chorionic villi into the lower uterine pole of pregnant women during the fi

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16

Rodrigues, N. R. "The human cytochrome P-450 21-hydroxylase genes." Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:77be8950-4675-4a55-ab4f-27b788082007.

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Deficiency of the cytochrome P-450 steroid 21-hydroxylase (21-OHase) which causes Congenital Adrenal Hyperplasia (CAH) is a monogenic autosomal recessive disorder which is linked to HLA. There are two 21-OHase genes in man, A and B, and they are mapped to the HLA class III region ~ 3 kb 3' to the complement genes C4A and C4B, respectively. Two genes encoding 21-OHase were isolated, characterized and sequenced. Both 21-OHase genes are ~ 3.3 kb in length and are split into 10 exons by nine introns. Comparison of the two genes showed that although they are highly conserved, there are three delete

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17

Schaffer, Marie. "HLA and KIR gene polymorphism in hematopoietic stem cell transplantation /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-836-3/.

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18

Chiu, Angela Chen-Yen. "DNA Typing of HLA-B by PCR with Primer Mixes Utilizing Sequence-Specific Primers." Thesis, University of North Texas, 1997. https://digital.library.unt.edu/ark:/67531/metadc278947/.

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The aim of this study was to design a resolution typing system for the HLA-B gene. This technique involves a one-step PCR reaction utilizing genomic DNA and sequence-specific primers to determine the specificity of each allele and to produce a larger primer data base ideal for serological analysis. The application of this technique to serological analysis can improve serology detection which is currently hindered by antibody cross-reactivity and the unavailability of useful typing reagents.

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19

Maruya, Etsuko. "Evidence that CD31, CD49b, and CD62L are immunodominant minor histocompatibility antigens in HLA identical sibling bone marrow transplants." Kyoto University, 2001. http://hdl.handle.net/2433/150586.

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20

Braga, Mayara Perez. "Alorreatividade dos enxertos ósseos homólogos na reconstrução alveolar em humanos." Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8418.

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Enxerto ósseo homólogo é utilizado independentemente da compatibilidade HLA entre doador e receptor ou uso de drogas imunossupressoras. Considerando o volume de transplantes ósseos realizados no Brasil e o possível efeito deletério da sensibilização HLA para o transplante de órgãos sólidos, este estudo tem como objetivo avaliar a alorreatividade do enxerto ósseo homólogo fresco-congelado utilizado na reconstrução alveolar com finalidade de reabilitação oral com prótese sobre implantes. Anticorpos anti-HLA e anti-MICA foram monitorados através do teste Labscreen Mixed, nos intervalos 0, 7, 30,

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21

Pecora, Rafael Antonio Arruda. "Associações dos anticorpos anti-HLA pré-formados e da compatibilidade HLA à rejeição celular aguda precoce no transplante hepático." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-09082016-154954/.

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INTRODUÇÃO: As moléculas HLA são os principais alvos da rejeição nos transplantes de órgãos sólidos. A influência dos anticorpos anti-HLA pré-formados e da compatibilidade HLA no transplante de fígado ainda não está bem definida. A maioria dos transplantes é realizada sem a pesquisa de anticorpos anti-HLA pré-formados e sem pareamento HLA. OBJETIVOS: Avaliar as associações dos anticorpos anti-HLA pré-formados e da compatibilidade HLA à rejeição celular aguda (RCA) em até 90 dias após o transplante. MÉTODOS: Coorte prospectiva de transplantes de fígado ABO compatíveis/idênticos realizados entre

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22

Pina, Fabiana Pompeo de. "Artrite reumatoide em Afro-brasileiros : "O papel do HLA"." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310626.

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Orientador: Manoel Barros Bertolo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-14T03:46:59Z (GMT). No. of bitstreams: 1 Pina_FabianaPompeode_M.pdf: 947949 bytes, checksum: 7e9310579d25142d2d37758ff60f7796 (MD5) Previous issue date: 2009<br>Resumo: A associação de antígenos de histocompatibilidade com a Artrite Reumatóide (AR) vem sendo demonstrada em inúmeros estudos. No entanto, a avaliação em populações afro-descendentes ainda foi pouco estudada. Os propósitos deste estudo foram os de determinar a freqüê

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23

Yin, Liusong. "Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation." eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/700.

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Antigen presented to CD4+ T cells by major histocompatibility complex class II molecules (MHCII) plays a key role in adaptive immunity. Antigen presentation is initiated by the proteolytic cleavage of pathogenic or self proteins and loading of resultant peptides to MHCII. The loading and exchange of peptides to MHCII is catalyzed by a nonclassical MHCII molecule, HLA-DM (DM). It is well established that DM promotes peptide exchange in vitro and in vivo. However, the mechanism of DM-catalyzed peptide association and dissociation, and how this would affect epitope selection in human responses to

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24

Scott, Carol Elizabeth DeWeese. "Molecular modeling and experimental characterization of HLA-DQ proteins and protein/peptide complexes : correlation with insulin-dependent diabetes mellitus (IDDM) /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8089.

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25

Wavamunno, Moses Dennis. "The role of pre-transplant antibodies in predicting chronic renal allograft injury." Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28207.

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Continued rise in the incidence of late graft loss despite better immunosuppression and improvement in acute rejection rates has led to renewed interest in the effect of HLA antibodies on long term graft outcomes. The significance of pre—transplant HLA antibodies detected by the widely used CDC assay on early graft outcomes is well studied. However, a lot remains unknown about effects of pre—transplant antibodies detected by sensitive solid phase assays on early and late graft outcomes. This is due to increased use of these assays resulting in better detection of HLA and non HLA antibo

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26

Lemy, Anne. "Do MICA antibodies impact on renal graft outcomes?" Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209617.

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La transplantation rénale représente le traitement de choix de l’insuffisance rénale terminale parce qu’il offre une espérance de vie plus longue et une meilleure qualité de vie.<p>Néanmoins, l’accès à la transplantation est limité par la pénurie d’organes et dans certains cas, par la présence d’anticorps anti-HLA avant la greffe.<p>Bien que la présence d’anticorps anti-HLA spécifiques du donneur avant ou après la greffe ait été associée au rejet aigu et à la perte chronique d’allogreffe, un rejet humoral tant aigu que chronique peut survenir sans que ces anticorps soient détectables dans le s

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27

Chang, Yea-wen, and 張雅雯. "Application of molecular genetic techniques to the study of major histocompatibility complex class II allelic associations with insulin-dependent diabetes mellitus in Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31213960.

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Felício, Leandro Prado. "Variabilidade e história evolutiva do gene HLA-E." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3597.

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Submitted by Erika Demachki (erikademachki@gmail.com) on 2014-11-11T20:37:41Z No. of bitstreams: 2 Dissertação - Leandro Prado Felício - 2013.pdf: 4839350 bytes, checksum: 07898140311917429ab55aa63ad5324e (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD5)<br>Approved for entry into archive by Erika Demachki (erikademachki@gmail.com) on 2014-11-11T20:38:05Z (GMT) No. of bitstreams: 2 Dissertação - Leandro Prado Felício - 2013.pdf: 4839350 bytes, checksum: 07898140311917429ab55aa63ad5324e (MD5) license_rdf: 23148 bytes, checksum: 9da0b6dfac957114c6a7714714b86306 (MD

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29

Foley, Bree Amanda. "The immunogenetics of natural killer cell alloreactivity." University of Western Australia. School of Pathology and Laboratory Medicine, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0242.

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[Truncated abstract] Natural killer (NK) cell alloreactivity can be exploited in haploidentical haematopoietic stem cell transplantation (HSCT) to improve graft survival, reduce graft versus host disease and decrease leukaemic relapse. NK cells lyse cells that have reduced expression of class I HLA molecules. In an allogeneic setting, donor NK cells may be activated by the absence of donor (self) class I HLA molecules on recipient cells; the absence of self-epitopes being detected by inhibitory KIR receptors on donor NK cells. The way in which genetic polymorphism of the receptors and ligands

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30

Yap, Cheng-Hon. "Factors influencing cryopreserved allograft heart valve degeneration." Connect to thesis, 2006. http://repository.unimelb.edu.au/10187/2120.

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Heart valve replacement is becoming more commonplace in developed nations. Despite this the ideal valve prosthesis has not been found. The allograft valve has been used for over 40 years and remains an important prosthesis with many advantages. However, like other biological valve prosthesis, they have a finite durability. The causes of allograft valve degeneration are still unknown. The study aims to identify factors associated with cryopreserved allograft valve degeneration. Knowledge of such factors will improve our understanding of the potential causes and mechanisms of allograft heart val

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31

Aly, Theresa Ann. "Novel MHC analyses allow prediction of extreme genetic risk for type 1A diabetes /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007. http://proquest.umi.com/pqdweb?did=1400957021&sid=1&Fmt=6&clientId=18952&RQT=309&VName=PQD.

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Thesis (Ph.D. in Human Medical Genetics) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 94-108). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;

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32

Lie, Hanne Cathrine. "The role of genetic diversity in human sexual selection : is the MHC special?" University of Western Australia. School of Psychology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0053.

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[Truncated abstract] The assumption that facial attractiveness signals mate quality is central to current evolutionary theories of human sexual selection. Evidence for direct links between attractiveness and mate quality is, however, scarce, and the exact nature of mate quality remains the subject of debate. Mate quality may include genetic diversity, because genome-wide diversity has been linked to individual fitness, and diversity within the Major Histocompatibility Complex (MHC) has been associated with immunocompetence and health in many species. This thesis investigates whether individual

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33

Gupta, Manu. "Autoimmune markers in autoimmune diabetes /." Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-756-8/.

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34

Santos, Kaisson Ernane dos. "Avaliação da história evolutiva do gene HLA-G por meio de polimorfismos de base única e da inserção AluyHG." Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/6686.

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Submitted by Luciana Ferreira (lucgeral@gmail.com) on 2017-01-04T13:00:39Z No. of bitstreams: 2 Dissertação - Kaisson Ernane dos Santos - 2013.pdf: 2738475 bytes, checksum: 6c79ab9177dd126fa5cb677127debc2c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2017-01-04T13:01:13Z (GMT) No. of bitstreams: 2 Dissertação - Kaisson Ernane dos Santos - 2013.pdf: 2738475 bytes, checksum: 6c79ab9177dd126fa5cb677127debc2c (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>

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35

Néel, Dominique. "Caracterisation des oligosaccharides n-lies d'antigenes hla-dr et de leurs cellules vectrices : contribution a l'etude des facteurs influencant la n-glycosylation." Paris 7, 1987. http://www.theses.fr/1987PA077138.

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Layet, Corine. "Approche des bases structurales de l'antigenicite des antigenes hla de classe i." Aix-Marseille 2, 1986. http://www.theses.fr/1986AIX22046.

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Garban, Frédéric. "Les molécules HLA de classe II dans les lymphocytes B de sang de cordon : présentation de l'antigène - transmission de signaux." Paris 7, 1997. http://www.theses.fr/1997PA077218.

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Les lymphocytes b de sang de cordon sont des cellules matures mais protegees des rencontresantigeniques exogenes. Les molecules hla de classe ii sont le support de la presentation antigenique et de la transmission de signaux intracellulaires d'activation ou de mort cellulaire programmee. Les cellules b de sang de cordon presentent de grandes quantites de molecules hla de classe ii vides mais la capacite d'allostimulation est preservee. Ces molecules hla de classe ii se presentent comme chez l'adulte sous forme de dimeres de dimeres, mais a la surface des lymphocytes b adultes la quantite de mo

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Zeliszewski, Dominique. "Etude du polymorphisme et du role des molecules hla de classe 2 a l'aide de clones de lymphocytes t restreints et specifiques d'antigenes viraux." Paris 7, 1987. http://www.theses.fr/1987PA077248.

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Quillet, Anne. "Role des antigenes hla classe i dans la susceptibilite a la cytotoxine naturelle nk/lak." Paris 7, 1988. http://www.theses.fr/1988PA077142.

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40

Heldt, Christian. "Differentielle Expression von HLA-DRB-Genen." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964994917.

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Amadou, Claire. "Structure et évolution du bras court du chromosome 6 humain : la région de classe I du complexe majeur d'histocompatibilité et sa partie distale." Toulouse 3, 1996. http://www.theses.fr/1996TOU30039.

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Le principe de cartographie comparative a ete suivi pour etudier l'evolution de la region de classe i du complexe majeur d'histocompatibilite (cmh). L'auteur a identifie et localise de nouveaux marqueurs conserves entre l'homme et la souris, qui ont permis une comparaison de la moitie distale du cmh entre les deux especes. Cette carte comparative met en evidence une structure conservee de la region de classe i, malgre l'absence d'orthologie entre les genes de classe i. L'auteur postule que les sequences non apparentees aux sequences de classe i sont representatives d'une structure ancestrale,

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42

Krief, Patricia. "Modulation de l'expression des antigenes d'histocompatibilite induite par l'interferon gamma : role d'un inhibiteur endogene et de la differenciation." Paris 6, 1987. http://www.theses.fr/1987PA066459.

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43

Meneghini, Maria Antonia Emilia. "Tracking preformed serological and T-cell alloimmune memory together with donor/recipient Molecular Human Leukocyte Antigen (HLA) disparity to improve immune-risk stratification in Kidney Transplantation." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673464.

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INTRODUCTION: The presence of a donor-specific alloimmune response negatively impacts allograft outcomes, being associated to risk of rejection and premature graft loss. Alloimmunity can be both preformed (memory) or can develop de novo after transplantation. The immune assays currently used in clinical practice to evaluate alloimmunity have several limitations and do not allow a complete and precise assessment of those two responses at time of transplantation. The hypothesis of this doctoral thesis is that at the time of kidney transplantation, an accurate characterization of pretransplant a

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44

Cayrol, Corinne. "Les molécules HLA de classe II : production d'anticorps monoclonaux pour la caractérisation de nouveaux épitopes polymorphes et étude du trafic intracellulaire des molécules DR et DQ." Toulouse 3, 1992. http://www.theses.fr/1992TOU30121.

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La region hla-d du complexe majeur d'histocompatibilite (cmh) humain, situe sur le bras court du chromosome 6, contient des genes codant les chaines alpha et beta des molecules hla de classe ii (dr, dq, dp). Ces molecules sont des glycoproteines membranaires a distribution tissulaire restreinte, qui presentent les fragments d'antigenes aux lymphocytes t auxiliaires. Elles ont une influence determinante sur la regulation de la reponse immunitaire, la susceptibilite a certaines maladies et la reponse aux allogreffes. Une particularite des molecules hla est leur tres grand polymorphisme. Bien que

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Saglibene, Hélène. "Prévention du rejet de greffe de cornée et complexe majeur d'histocompatibilité." Bordeaux 2, 1992. http://www.theses.fr/1992BOR23061.

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Triebel, Frédéric. "Analyse fonctionnelle et structurale des antigènes membranaires ayant un rôle dans la réponse proliférative de clones lymphocytaires T humains spécifiques de l'anatoxine diphtérique." Paris 6, 1986. http://www.theses.fr/1986PA066147.

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Poizot-Martin, Isabelle. "Signalisation induite par les molécules HLA de classe II dans les cellules B lymphoïdes normales et malignes folliculaires." Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10170.

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Les lymphomes b non-hodgkiniens font partie des rares tumeurs a exprimer des molecules hla de classe ii. Ceci leur permet d'interagir directement avec les lymphocytes t cd4+ qui infiltrent la tumeur (til-t). La signalisation induite par les molecules hla-dr peut induire soit l'apoptose, soit la proliferation. La premiere partie de ce travail a ete d'etudier le role joue par les molecules hla de classe ii dans l'interaction entre les til-t cd4+ et les lymphocytes b malins de lymphome folliculaire. Par l'intermediaire des molecules hla de classe ii, des clones de til-t cd4+ sont capables d'indui

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Jeanmougin, Marc. "Imputation HLA et analyse génomique de la coinfection VIH/VHC." Thesis, Paris, CNAM, 2017. http://www.theses.fr/2017CNAM1164/document.

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La génomique d'association cherche à déterminer des liens entre le génome et des traits ou phénotypes, notamment dans le contexte de maladies. Aujourd'hui, les études les plus fréquentes en génomique d’association sont les études génome entier, qui analysent autant de variants du génomes (SNPs) que possible, sans avoir de préjugé a priori sur leur fonction biologique. Cependant, les méthodes de génotypage utilisées pour ces études ne permettent pas toujours d'obtenir des informations précises dans une région hypervariable comme la région HLA, qui joue un rôle crucial dans l'immunité, et les va

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Dilthey, Alexander Tilo. "Statistical HLA type imputation from large and heterogeneous datasets." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1bca18bf-b9d5-4777-b58e-a0dca4c9dbea.

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An individual's Human Leukocyte Antigen (HLA) type is an essential immunogenetic parameter, influencing susceptibility to a variety of autoimmune and infectious diseases, to certain types of cancer and the likelihood of adverse drug reactions. I present and evaluate two models for the accurate statistical determination of HLA types for single-population and multi-population studies, based on SNP genotypes. Importantly, SNP genotypes are already available for many studies, so that the application of the statistical methods presented here does not incur any extra cost besides computing time. HLA

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Ciarlariello, Paul David. "IFN-Gamma-Mediated Immunoevasive Strategies in Multiple Myeloma." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460656019.

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