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1

González, Antonio Pablo. "IDENTIFICACIÓN DE LOS GENES: Stx1, Stx2, eaeA Y hlyA, EN CEPAS DE Escherichia coli AISLADAS DE CANALES Y CARNE PROCESADA DE OVINOS." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2018. http://hdl.handle.net/20.500.11799/94389.

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E. coli productora de toxina shiga (ECST) y E. coli enterohemorrágica (ECEH) pertenecen a los grupos patógenos de Escherichia coli causantes de enfermedades diarreicas. La presencia de ECST y ECEH en estas enfermedades diarreicas se atribuye principalmente al consumo de vegetales y carnes provenientes de bovinos y ovinos contaminados con estos grupos patógenos y que actualmente se encuentran dentro de las etiologías más importantes del grupo de Enfermedades Trasmitidas por Alimentos (ETA). ECST y ECEH presentan los genes Stx1, Stx2, eaeA y hlyA que codifican a proteínas con cualidades toxicas
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Holden, James Anthony, and jamesholden@netspace net au. "Vaccination Strategies for the Prevention of Swine Dysentery." RMIT University. Applied Sciences, 2006. http://adt.lib.rmit.edu.au/adt/public/adt-VIT20070112.122102.

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The SmpA outer membrane lipoprotein of B. hyodysenteriae has several characteristics that indicate the potential to protect against swine dysentery (SD). It localises to the outer membrane and antibodies directed against SmpA can prevent the growth of B. hyodysenteriae in vitro. There is some variation observed in the distribution and expression of the SmpA lipoprotein, suggesting that vaccination with SmpA may not provide protection against challenge with a heterologous B. hyodysenteriae strain. This study has characterised the variation at the smpA locus, and in the process has identified
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3

Diabaté, Mamady. "Étude des relations fonctionnelles entre les toxines CNF1 et alpha-hémolysine (HlyA) des Escherichia coli uropathogènes." Nice, 2011. http://www.theses.fr/2011NICE4039.

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Le facteur cytotoxique nécrosant-1 (CNF1) et l’hémolysine-alpha (HlyA) sont les deux toxines majeures des Escherichia coli uropathogènes (UPEC), premier agent étiologique des infections du tractus urinaire (ITU) et principale cause de bactériémie à E. Coli. Comme plusieurs autres facteurs de virulence, ces toxines ont été associées à l’ITU en raison de leur grande prévalence dans les UPEC par rapport aux E. Coli fécaux, respectivement 30 % et 0. 9 % pour CNF1. Cependant, leurs rôles dans la physiopathologie de l’infection urinaire reste imprécis. Dans un modèle murin de bactériémie, nous avons
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4

Ha, Thi Quyen. "Analysis of gene encoding haemolysin A of Vibrio cholerae isolated in Vietnam." Technische Universität Dresden, 2018. https://tud.qucosa.de/id/qucosa%3A33123.

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Vibrio cholerae is the cholera causing agent, divided into two biotypes, including the classical biotype and ElTor biotype. Both of these biotypes caused cholera epidemics in the world. The classical biotype caused 6th cholera pandemic (from 1921 to 1961), and ElTor biotype caused 7th cholera pandemic (from 1961 to the 70s). Haemolysin A, a hemolytic protein of V. cholerae ElTor biotype, is encoded by the hlyA gene. This gene is often used for analyzing genetic relationship between strains in the same species or between species in the same Vibrio genus. Results of analyzing nucleotide and amin
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5

Guzmán-Verri, Caterina. "Virulence mechanisms of two Gram negative bacteria : studies on Escherichia coli hemolysin HlyA and on the interaction of Brucella abortus with non-phagocytic cells /." Stockholm : Karolinska Univ. Press, 2002. http://diss.kib.ki.se/2002/91-7349-114-4.

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Franco, Roger Teixeira. "Caracterização de amostras de Escherichia coli eae positivas isoladas de crianças com diarreia aguda e sem diarreia em Belo Horizonte: tipagem de intimina e pesquisa de hlyA, iha e toxB." Universidade Federal de Minas Gerais, 2012. http://hdl.handle.net/1843/ENMS-8RWQMM.

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Infectious diarrhea is still a main cause of morbidity and mortality among children from the less developed areas of the world. Among several etiologic agents, a group of diarrheagenic Escherichia coli (DEC) named attaching and effacing E. coli (AEEC), associated to the genesis of the intimin-mediated A/E lesion in enterocytes, should be mentioned. AEEC includes typical (tEPEC) and atypical (aEPEC) subgroups of enteropathogenic E. coli (EPEC) and the pathotype enterohemorrhagic E. coli (EHEC) that also expresses shiga toxin. All of them, mainly aEPEC, are genetically diverse, especially in reg
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7

Ping, Ivan Chang Kok. "HLA performance measurement." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2000. http://handle.dtic.mil/100.2/ADA376484.

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Thesis (M.S. in Modeling, Virtual Environments and Simulation (MOVES))--Naval Postgraduate School, March 2000.<br>Thesis advisor(s): Zyda, Michael ; Bachmann, Eric. "March 2000." Includes bibliographical references (p. 77). Also available in print.
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8

Lachaud, Laurence. "Reconnaissance allogénique HLA." Montpellier 1, 1995. http://www.theses.fr/1995MON11145.

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9

FODIL, NASSIMA. "Nouvelle diversite hla." Université Louis Pasteur (Strasbourg) (1971-2008), 2001. http://www.theses.fr/2001STR1A001.

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Au cours de ces 10 dernieres annees, de nombreux genes homologues aux molecules de classes i du complexe majeur d'histocompatibilite (cmh) ont ete mis en evidence. Ils exhibent, pour la plupart, une expression tissulaire restreinte et ne semblent pas avoir pour fonction la presentation peptidique aux cellules t. La famille des genes mic (mhc class i chain-related genes) a recemment ete caracterisee au sein meme de la region de classe i du cmh. Elle se compose de 2 genes fonctionnels (mica et micb) ainsi que de 5 pseudogenes (micc-g). Les travaux presentes dans cette these decrivent le polymorp
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10

Brown, Juliette. "HLA-DR and HLA-DQ polymorphism and associations in different populations." Thesis, Queen Mary, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287875.

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Schulte, Kathleen Q. "Mutagenized HLA DNA Constructs: Tools for Validating Molecular HLA Typing Methodologies." Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc500888/.

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This study describes the development and validation of mutagenized cloned DNA constructs, which correspond to the polymorphic regions of the class II region of the HLA complex. The constructs were used to verify the allelic specificity of primers and probes in polymerase chain reaction (PCR)-based HLA typing assays such as Sequence Specific Primers (SSP) and Sequence Specific Oligonucleotide Probes (SSOP). The constructs consisted of the entire polymorphic region of exon 2 of class II HLA allele sequences that included primer annealing sites or probe hybridization sites. An HLA allele sequence
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12

Porto, Iane de Oliveira Pires. "Estrutura e variabilidade da região 3’não-traduzida dos genes HLA-A, HLA-C e HLA-G e perfil de ligação de microRNAs." Botucatu, 2018. http://hdl.handle.net/11449/180582.

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Orientador: Erick da Cruz Castelli<br>Resumo: O complexo gênico de Antígenos Leucocitário Humanos (HLA) é a região mais variável do genoma humano. Os genes HLA de classe I são divididos em clássicos e não clássicos, a depender de suas funções primárias, níveis de expressão e polimorfismos. Assim, HLA-A, HLA-B e HLA-C são loci clássicos e estão associados à apresentação antigênica para células T citotóxicas, enquanto HLA-E, HLA-G e HLA-F são loci não clássicos e estão associados à imunomodulação e inibição de células T e NK. No entanto, o HLA-C também apresenta propriedades imunomodulatórias a
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13

Selleski, Nicole. "Prevalência de alelos HLA predisponentes para a doença celíaca (HLA-DQ2 e HLA-DQ8) em crianças celíacas e não celíacas." reponame:Repositório Institucional da UnB, 2015. http://repositorio.unb.br/handle/10482/19497.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, Programa de Pós-Graduação em Ciências da Saúde, 2015.<br>Submitted by Fernanda Percia França (fernandafranca@bce.unb.br) on 2016-02-12T13:36:10Z No. of bitstreams: 1 2015_NicoleSelleski.pdf: 1794617 bytes, checksum: ea6f372597cf25bb16cfdc52ec8a1d29 (MD5)<br>Approved for entry into archive by Guimaraes Jacqueline(jacqueline.guimaraes@bce.unb.br) on 2016-02-15T11:43:09Z (GMT) No. of bitstreams: 1 2015_NicoleSelleski.pdf: 1794617 bytes, checksum: ea6f372597cf25bb16cfdc52ec8a1d29 (MD5)<br>Made available in DSpace on
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Müller, Lutz Peter. "Typisierung der HLA-DPB1-Allele und HLA-Assoziation der chronisch lymphatischen Leukämie." [S.l.] : [s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=962022144.

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Probe, Christine. "Der Einfluss von HLA-G und HLA-E auf large granular lymphocytes." Doctoral thesis, [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=97223330X.

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Querino, Gislaine Aparecida. "Estudo de associação dos genes HLA-DPA1 e HLA-DPB1 em Hanseníase." Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/157166.

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Submitted by Gislaine Aparecida Querino (gislainequerino@hotmail.com) on 2018-09-28T01:32:53Z No. of bitstreams: 1 Querino,GA.pdf: 869186 bytes, checksum: 86a067f5db0e67b546c8ad7691a3d530 (MD5)<br>Approved for entry into archive by ROSANGELA APARECIDA LOBO null (rosangelalobo@btu.unesp.br) on 2018-09-28T12:55:41Z (GMT) No. of bitstreams: 1 querino_ga_dr_bot.pdf: 869186 bytes, checksum: 86a067f5db0e67b546c8ad7691a3d530 (MD5)<br>Made available in DSpace on 2018-09-28T12:55:41Z (GMT). No. of bitstreams: 1 querino_ga_dr_bot.pdf: 869186 bytes, checksum: 86a067f5db0e67b546c8ad7691a3d530 (MD5)
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Persson, Gunnar. "Connecting SOAR to HLA." Thesis, Uppsala University, Department of Information Technology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98316.

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<p>This Master Thesis report explains the project of trying to connect the humancognition architecture Soar (an AI architecture) to the simulation architecture HLA (High Level Architecture). Descriptions of both Soar and HLA are presented.</p><p>A connection between the two, whose main objective is the transfer of relevant data between Soar and HLA, is not a completely straightforward task. The task involves many different aspects of the HLA architecture, including threading in HLA interfaces, dealing with the HLA data representation, time management, transfer of ownership of HLA objects, HLA
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Yang, Edward Kuo-Liang. "Serological identification and characterization of new HLA class I and non-HLA antigens." Thesis, University of Ottawa (Canada), 1995. http://hdl.handle.net/10393/9538.

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This report embarks on an investigation of the ethnic diversity, using alloantisera, of three groups of HLA class I antigens, namely A2, A11, and C-locus antigens, and to define antigens that might be restricted to certain ethnic populations. As transplantation therapy has been widely accepted as the choice of treatment for patients with severe haematological disorders, such as acute leukemia, it is essential to match MHC antigens of unrelated donor and recipient pairs to avoid graft rejection or graft-versus-host disease and to reduce administration of immune suppressants. Results obtained fr
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Nguyen-Thi, Huong-Thu. "Etude des anticorps antilymphocytaires (HLA & non HLA) en présence de globules rouges." Université Louis Pasteur (Strasbourg) (1971-2008), 1985. http://www.theses.fr/1985STR1M176.

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Elsherbini, Sherif. "L'influence de polymorphismes de gène de Non-HLA (Cytokines) et non classiques HLA (HLA-E) sur les résultats de transplantation de moelle." Paris 7, 2006. http://www.theses.fr/2006PA077039.

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Cette étude a été concentrée sur L'influence de polymorphismes de gène de Non-HLA (Cytokines) et non classiques HLA (HLA-E) sur les résultats de transplantation de moelle. 91 patients indiens avec la bêta-thalassémie major et leurs donateurs ont été analysés. Des études de polymorphisme de gène ont été réalisées sur des groupes d'ADN de 91 patient et de leurs donateurs respectifs. Génotypes de distributeur/réceptifs pour le TNF-α308, IL-6-174, IL-10-1082-, -819,-592, IFN-γ-874 and TGF-β1+869, +-915 polymorphismes ont été analysés par PCR-SSP. HLA-E genoryping a été exécuté par SSP. Association
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BOISGERAULT, FLORENCE. "Etude des peptides presentes par les molecules hla de classe i predisposant aux pathologies autoimmunes : exemples des molecules hla-a29 et hla-b27." Paris 7, 1998. http://www.theses.fr/1998PA077017.

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Les molecules du complexe majeur d'histocompatibilite humain (hla) ont pour fonction de presenter des peptides aux lymphocytes t charges de la surveillance immunitaire. Certaines molecules hla predisposent au developpement de pathologies auto-immunes, en particulier les molecules hla-a29 et hla-b27. Nous avons etudie leurs caracteristiques de presentation peptidique grace a une approche biochimique d'elution de peptides. Les molecules hla-a29 conferent une susceptibilite aux retinopathies de type birdshot et les antigenes retiniens ag-s et irbp dont de potentiels autoantigenes. Pour determiner
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Allan, David Simon Joseph. "Non-classical MHC class I molecules HLA-E and HLA-G and their ligands." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365371.

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Pires, Catarina Fernandes 1956. "Estudo do HLA-DR e HLA-DQ em pacientes piauienses com artrite idiópática juvenil." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312850.

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Orientador: Manoel Barros Bertolo<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-26T03:37:39Z (GMT). No. of bitstreams: 1 Pires_CatarinaFernandes_D.pdf: 2601322 bytes, checksum: 1acb7f604b763cb1fd45c71455e387bf (MD5) Previous issue date: 2014<br>Resumo: O presente estudo de caso-controle avaliou 74 crianças piauienses com Artrite Idiopática Juvenil (AIJ) em suas diversas formas: Oligoarticular, Sistêmica, Poliarticular Fator Reumatoide Positivo (FR+), Poliarticular Fator Reumatoide Negativo (FR-), Artrite relacion
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Barra, Claude. "Analyse du répertoire T cytotoxique HLA-restreint de souris transgéniques HLA de classe I." Aix-Marseille 2, 1992. http://www.theses.fr/1992AIX22044.

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Le developpement d'un modele de souris transgeniques pour des molecules d'histocompatibilite de classe i humaines dans le but d'etudier les reponses cytotoxiques chez l'homme se heurte au probleme de la cooperation heterospecifique entre molecules d'histocompatibilite humaines (hla) et complexe de reconnaissance t murin (recepteur t et molecules accessoires). Le repertoire t cytotoxique de ces animaux reste majoritairement restreint par les molecules d'histocompatibilite de souris et l'utilisation des molecules hla de classe i demeure marginale
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ZANE, L. S. "Expressão de HLA-G e HLA-G5 em pacientes com Síndrome de Parry-Romberg." Universidade Federal do Espírito Santo, 2015. http://repositorio.ufes.br/handle/10/4508.

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Made available in DSpace on 2016-08-29T15:34:36Z (GMT). No. of bitstreams: 1 tese_9536_Dissertac&#807;a&#771;o completa versa&#771;o final.pdf: 3098397 bytes, checksum: bed15892e2bc7fb6e3d38393c123bc36 (MD5) Previous issue date: 2015-10-27<br>A Síndrome de Parry-Romberg (SPR) ou Atrofia hemifacial progressiva (HFA) é uma doença rara (1:250.000 a 1:700.000), de causa desconhecida, caracterizada por atrofia unilateral da face, acometendo pele, tecidos moles, músculos e tecidos ósseos subjacentes de forma lenta, progressiva e autolimitada. A patogênese da SPR é heterogênea, parece ser sobrepost
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Hla, Yin Myint Sasithon Pukrittayakamee. "A systematic overview of published antimalarial drug trials /." Abstract, 2003. http://mulinet3.li.mahidol.ac.th/thesis/2546/46E-Hla-Y.pdf.

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Evison, Martin Paul. "Ancient HLA : a preliminary investigation." Thesis, University of Sheffield, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245563.

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Lepin, Eric Jean-Marie. "Functional characterisation of HLA-F." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270936.

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Allsopp, Catherine E. M. "HLA in sub-Saharan Africa." Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316694.

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Lowe, David Philip. "Characterisation of HLA-specific antibodies." Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/58070/.

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A successful kidney transplant is the best treatment for established renal failure, yet around 300 patients per annum are denied transplants because they have antibodies, most notably directed against donor HLA or ABO in their blood, which have the potential to cause acute and chronic rejection of the transplant. Such antibodies are present in 25% (roughly 1750 of the 7000 on the kidney transplant waiting list) of the patients listed for a deceased donor transplant. Programmes to remove antibody and transplant patients across HLA antibody barriers have been developed, but are limited by a high
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Bréholée, Benoît. "Interconnexion de simulations distribuées HLA." École nationale supérieure de l'aéronautique et de l'espace (Toulouse ; 1972-2007), 2005. http://www.theses.fr/2005ESAE0003.

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Cette thèse s’inscrit dans le contexte de HLA, une architecture de simulation distribuée dont l'objectif est de permettre l'interopérabilité et la réutilisation d’applications de simulation. L'ONERA a développé une plate-forme de simulation distribuée compatible HLA (appelée CERTI). L'objectif de cette thèse est d'étendre le travail entrepris sur CERTI en se basant sur l'introduction de la notion classique de domaine. Nous étudions différentes techniques impliquant cette notion et dont les objectifs concernent l'interopérabilité, la sécurité, la réutilisation ainsi que l'amélioration des perfo
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Seeger, Wolf-Adam. "Untersuchung von nierentransplantierten Patienten unter Berücksichtigung der HLA-Kompatibilität und der Dynamik der HLA-Antikörperbildung." [S.l.] : [s.n.], 2005. http://deposit.ddb.de/cgi-bin/dokserv?idn=974558214.

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Pajot, Anthony. "Souris HLA-classe I / HLA-classe II transgéniques H-2 classe I / classe II KO." Paris 6, 2005. http://www.theses.fr/2005PA066234.

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Seeger, Wolf-Adam. "Untersuchung von nierentransplantierten Patienten unter Berücksichtigung der HLA-Kompatibilität und der Dynamik der HLA-Antikörperbildung." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15232.

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In dieser Arbeit wurde die Überlebenszeit von Nierentransplantaten untersucht und deren Abhängigkeit von zwei Faktoren: der HLA-Kompatibilität und der Antikörperdynamik. Hierzu konnten Daten von 327 Patienten gesammelt werden, die zwischen 1991 und 1996 eine postmortale Spenderniere erhielten. Eine konventionelle Gewebetypisierung erfolgte mittels serologischer und molekularbiologischer Untersuchungen. Eine neue Matchingmethode wurde durchgeführt auf Ebene von Aminosäuren. Ein Antikörperscreening erfolgte vor und nach Transplantation mittels Lymphozytotoxtest und ELISA. Zur statistischen Bewe
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Bértolo, Manoel Barros 1955. "Genotipagem na artrite reumatoide. Alelos HLA-classe II : HLA-DRB1 *0101 e *0102 associados a suscetibilidade e HLA-DRB1 *0401 e *0404 associados a agressividade." [s.n.], 1996. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310435.

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Orientadores: Lilian Tereza Lavras Costallat, Fernando Ferreira Costa<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-07-21T16:00:30Z (GMT). No. of bitstreams: 1 Bertolo_ManoelBarros_D.pdf: 5744580 bytes, checksum: f7167e9a18551a891129b8899097c781 (MD5) Previous issue date: 1996<br>Resumo: A associação de antígenos de histocompatibilidade com a artrite reumatóide (AR) vem sendo demonstrada em inúmeros estudos. A principal associação em população caucasóide é com o HLA-DR4, contudo, também vem sendo observada com HLA-D
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Auger, Isabelle. "Isolement et caracterisation de ligands specifiques de la troisieme region hypervariable de hla-drb1#*0401 (hla-dr4 dw4). Implications pour l'association polyarthrite rhumatoide et hla-dr4." Aix-Marseille 2, 1997. http://www.theses.fr/1997AIX22032.

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La sequence qkraa de la troisieme region hypervariable de hla-drb1#*0401 porte la susceptibilite a developper une polyarthrite rhumatoide. Le role de la sequence qkraa n'est pas encore connu. Il implique sans doute une interaction avec un ou plusieurs ligands. Nous avons recherche si la sequence qkraa de la troisieme region hypervariable de hla-drb1#*0401 interagit avec des proteines susceptibles de jouer un role dans la polyarthrite rhumatoide. Nous avons montre que : 1- le peptide de troisieme region hypervariable de hla-drb1#*0401 contenant qkraa fixe specifiquement la proteine de choc ther
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Ichise, Hiroshi. "NK cell alloreactivity against KIR-ligand-mismatched HLA-haploidentical tissue derived from HLA haplotype-homozygous iPSCs." Kyoto University, 2017. http://hdl.handle.net/2433/228232.

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Hardie, Kim R. "In vitro HlyC-dependent activation of Escherichia coli prohemolysin." Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386322.

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39

Heldt, Christian. "Differentielle Expression von HLA-DRB-Genen." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964994917.

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40

Topcu, Okan. "Metamodeling For The Hla Federation Architectures." Phd thesis, METU, 2007. http://etd.lib.metu.edu.tr/upload/3/12609187/index.pdf.

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This study proposes a metamodel, named Federation Architecture Metamodel (FAMM), for describing the architecture of a High Level Architecture (HLA) compliant federation. The metamodel provides a domain specific language and a formal representation for the federation adopting Domain Specific Metamodeling approach to HLA-compliant federations. The metamodel supports the definitions of transformations both as source and as target. Specifically, it supports federate base code generation from a described federate behavior, and it supports transformations from a simulation conceptual model. A salien
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41

Dinc, Ali Cem. "Hla Fom Development With Model Transformations." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/12611793/index.pdf.

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There has been a recent interest in the model-based development approach in the modeling and simulation community. The Model-Driven Architecture (MDA) of OMG envisions a fully model-based development process where models are created for capturing not only requirements, but also designs and implementations. Domain-specific metamodels and model transformations constitute the cornerstones of this approach. We have developed transformations from the data part of Field Artillery (FA) domain models to High Level Architecture (HLA) Object Model Template (OMT) models, honoring the MDA philosophy. In t
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42

Koksal, Algin Ceren Fatma. "Ontology Driven Development For Hla Federates." Master's thesis, METU, 2010. http://etd.lib.metu.edu.tr/upload/3/12611943/index.pdf.

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This thesis puts forth a process for ontology driven distributed simulation through a case study. Ontology is regarded as a domain model, including objects, attributes, methods and object relations. The case study involves trajectory simulation. A trajectory simulation is a piece of software that calculates the flight path and other parameters of a munition, such as its orientation and angular rates, from launch to impact. Formal specification of trajectory simulation domain is available as a domain model in the form of an ontology, called Trajectory Simulation ONTology (TSONT). Ontology drive
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Zhao, Hui. "HLA streaming and real-time extensions." Thesis, University of Ottawa (Canada), 2002. http://hdl.handle.net/10393/6339.

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The High Level Architecture (HLA) is IEEE's 1516 standard [1] which defines a software architecture for the development and execution of Distributed Interactive Simulation (DIS). It also provides a general-purpose network communication mechanism for DIS through its implementation---Run-Time Infrastructure (RTI). However, HLA does not address two critical features: stream (audio/video) and real-time transmission. This thesis focuses on solving these two issues. The first part of this thesis reviews the basic concepts of DIS and its evolving history. Then it illustrates how the HLA supports the
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44

Allen, Rachel Louise. "T cell recognition of HLA B27." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299779.

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Rached, Marici Rached. "Papel do HLA-G na endometriose." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5146/tde-06092017-121750/.

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A endometriose é uma doença inflamatória crônica, estrógeno-dependente e de etiologia multifatorial, caracterizada pela implantação e crescimento de tecido endometrial fora da cavidade uterina e associada à dor pélvica e infertilidade. A doença é classificada de acordo com os estádios e sítios de acometimento nos órgãos pélvicos. Variantes genéticas, endócrinas e ambientais podem contribuir para a geração de uma deficiência na resposta imune local permitindo a implantação das células ectópicas na cavidade pélvica. Alterações constatadas no padrão de citocinas presentes no microambiente pélvico
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46

Francisco, Rodrigo dos Santos. "Unidades de seleção nos genes HLA." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/41/41131/tde-16042014-142152/.

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Os genes HLA (Antígenos leucocitários humanos) estão localizados no Complexo Principal de Histocompatibilidade humano (o MHC), e possuem os maiores níveis de variação do genoma, com milhares de alelos, altas taxas de heterozigose e diversidade nucleotídica. No presente estudo, nosso objetivo foi a identificação dos principais alvos da seleção natural nos genes HLA. Para isso, propusemos duas abordagens que resultaram na redação de dois manuscritos. Na primeira abordagem, nós testamos a hipótese de que os principais alvos da atuação da seleção natural nas moléculas HLA seriam os aminoácidos que
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47

Penven, Jean-François. "Hémochromatoses secondaires et l'alléle Hla A3." Montpellier 1, 1988. http://www.theses.fr/1988MON11239.

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Karnes, Jason H., Christian M. Shaffer, Lisa Bastarache, et al. "Comparison of HLA allelic imputation programs." PUBLIC LIBRARY SCIENCE, 2017. http://hdl.handle.net/10150/623042.

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Imputation of human leukocyte antigen (HLA) alleles from SNP-level data is attractive due to importance of HLA alleles in human disease, widespread availability of genome-wide association study (GWAS) data, and expertise required for HLA sequencing. However, comprehensive evaluations of HLA imputations programs are limited. We compared HLA imputation results of HIBAG, SNP2HLA, and HLA* IMP: 02 to sequenced HLA alleles in 3,265 samples from BioVU, a de-identified electronic health record database coupled to a DNA biorepository. We performed four-digit HLA sequencing for HLA-A, -B, -C, -DRB1, -D
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CRIVELLO, PIETRO. "New molecular insights into HLA immunogenicity." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/29854.

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Alloreactivity is the major barrier to solid organ and hematopoietic stem cell transplantation (HSCT), determining important clinical events such as graft rejection and graft versus host disease. This biological phenomenon is due to the immunogenicity of allogeneic Human Leukocyte Antigens (HLA) expressed in transplanted tissues and recognized by T cell receptor (TCR) on the surface of alloreactive T cells. In the past, the hosting laboratory identified an immunogenic T cell epitope (TCE) encoded by a subset of HLA-DPB1 alleles, thereby defining permissive and non-permissive DPB1 mismatches be
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Nishimura, Wester Eidi 1975. "Associação do HLA-B*14 e HLA-Cw*08 com a suscetibilidade para vasculite reumatóide (VR) e HLA-DRB5*01 na proteção para VR em pacientes brasileiros." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310632.

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Orientador: Manoel Barros Bértolo<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-16T11:59:40Z (GMT). No. of bitstreams: 1 Nishimura_WesterEidi_M.pdf: 1381412 bytes, checksum: a01c05ab2c7b9409c11bde6b5d507e4f (MD5) Previous issue date: 2010<br>Resumo: O objetivo do presente estudo foi avaliar a freqüência e a associação clínica do HLA classe I e II em pacientes brasileiros com vasculite reumatóide (VR). Nós avaliamos 57 pacientes com artrite reumatóide (AR) estabelecida pelos critérios do Colégio Americano de
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