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Gotowe bibliografie tematyczne / Hormones, Sex – Receptors / Artykuły w czasopismach

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Artykuły w czasopismach na temat „Hormones, Sex – Receptors”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 9 lutego 2022

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1

Honma, Naoko, Yoko Matsuda, and Tetuo Mikami. "Carcinogenesis of Triple-Negative Breast Cancer and Sex Steroid Hormones." Cancers 13, no. 11 (May 25, 2021): 2588. http://dx.doi.org/10.3390/cancers13112588.

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Triple-negative breast cancer (TNBC) lacks an effective treatment target and is usually associated with a poor clinical outcome; however, hormone unresponsiveness, which is the most important biological characteristic of TNBC, only means the lack of nuclear estrogenic signaling through the classical estrogen receptor (ER), ER-α. Several sex steroid receptors other than ER-α: androgen receptor (AR), second ER, ER-β, and non-nuclear receptors represented by G-protein-coupled estrogen receptor (GPER), are frequently expressed in TNBC and their biological and clinical importance has been suggested

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Zarazúa, Abraham, Aliesha González-Arenas, Gabriela Ramírez-Vélez, Blanca Bazán-Perkins, Christian Guerra-Araiza, and María G. Campos-Lara. "Sexual Dimorphism in the Regulation of Estrogen, Progesterone, and Androgen Receptors by Sex Steroids in the Rat Airway Smooth Muscle Cells." International Journal of Endocrinology 2016 (2016): 1–11. http://dx.doi.org/10.1155/2016/8423192.

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The role of sex hormones in lung is known. The three main sex steroid receptors, estrogen, progesterone, and androgen, have not been sufficiently studied in airway smooth muscle cells (ASMC), and the sex hormone regulation on these receptors is unknown. We examined the presence and regulation of sex hormone receptors in female and male rat ASMC by Western blotting and flow cytometry. Gonadectomized rats were treated with 17β-estradiol, progesterone, 17β-estradiol + progesterone, or testosterone. ASMC were enzymatically isolated from tracheas and bronchi. The experiments were performed with dou

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Baber, Rod. "Sex hormones, receptors and modulators." Australian and New Zealand Journal of Obstetrics and Gynaecology 57, no. 4 (August 2017): 391–92. http://dx.doi.org/10.1111/ajo.12666.

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Orshal, Julia M., and Raouf A. Khalil. "Gender, sex hormones, and vascular tone." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 286, no. 2 (February 2004): R233—R249. http://dx.doi.org/10.1152/ajpregu.00338.2003.

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The greater incidence of hypertension and coronary artery disease in men and postmenopausal women compared with premenopausal women has been related, in part, to gender differences in vascular tone and possible vascular protective effects of the female sex hormones estrogen and progesterone. However, vascular effects of the male sex hormone testosterone have also been suggested. Estrogen, progesterone, and testosterone receptors have been identified in blood vessels of human and other mammals and have been localized in the plasmalemma, cytosol, and nuclear compartments of various vascular cell

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5

Fannon, Stacey A., Regina M. Vidaver, and Sherry A. Marts. "Historical Perspectives: An abridged history of sex steroid hormone receptor action." Journal of Applied Physiology 91, no. 4 (October 1, 2001): 1854–59. http://dx.doi.org/10.1152/jappl.2001.91.4.1854.

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The field of steroid hormone action is well established, although it is barely more than four decades old. Pivotal experiments in the late 1950s and 1960s showed that hormone-binding components exist within nuclei of target tissues and that steroid hormones act by regulating gene expression, rather than directly influencing enzymatic processes. The understanding that steroid hormone receptors interact with the general transcription machinery and alter chromatin structure came in the 1970s and 1980s, and details of this mechanism continue to be elucidated. In addition, the discovery of rapid ce

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6

Simão, Vinícius Augusto, Luiz Gustavo de Almeida Chuffa, and Isabel Cristina Cherici Camargo. "Ovarian sex steroid receptors and sex hormones in androgenized rats." Reproduction 152, no. 5 (November 2016): 545–59. http://dx.doi.org/10.1530/rep-16-0233.

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This study evaluated for the first time the effects of different doses of the anabolic steroid nandrolone decanoate (ND) on the expression of ovarian steroid receptors (AR, ER-α (ESR1) and ER-β (ESR2)) and related sex hormones after treatment and recovery periods in adult rats. The animals were injected subcutaneously with doses of ND (1.87, 3.75, 7.5 or 15 mg/kg b.w.) or mineral oil (control group) for 15 days, and the experimental groups were divided into three periods of evaluation: (a) ND treatment for 15 days, (b) ND treatment and recovery for a period of 30 days and (c) ND treatment and

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7

Bhatia, Aruna, Harmandeep Kaur Sekhon, and Gurpreet Kaur. "Sex Hormones and Immune Dimorphism." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/159150.

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The functioning of the immune system of the body is regulated by many factors. The abnormal regulation of the immune system may result in some pathological conditions. Sex hormones of reproductive system are one of the major factors that regulate immune system due to the presence of hormone receptors on immune cells. The interaction of sex hormones and immune cells through the receptors on these cells effect the release of cytokines which determines the proliferation, differentiation, and maturation of different types of immunocytes and as a result the outcome of inflammatory or autoimmune dis

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8

Simoncini, T., and AR Genazzani. "Non-genomic actions of sex steroid hormones." European Journal of Endocrinology 148, no. 3 (March 1, 2003): 281–92. http://dx.doi.org/10.1530/eje.0.1480281.

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Steroid hormone receptors have been traditionally considered to act via the regulation of transcriptional processes, involving nuclear translocation and binding to specific response elements, and ultimately leading to regulation of gene expression. However, novel non-transcriptional mechanisms of signal transduction through steroid hormone receptors have been identified. These so-called 'non-genomic' effects do not depend on gene transcription or protein synthesis and involve steroid-induced modulation of cytoplasmic or cell membrane-bound regulatory proteins. Several relevant biological actio

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9

Higa, Gerald M., and Ryan G. Fell. "Sex Hormone Receptor Repertoire in Breast Cancer." International Journal of Breast Cancer 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/284036.

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Classification of breast cancer as endocrine sensitive, hormone dependent, or estrogen receptor (ER) positive refers singularly to ERα. One of the oldest recognized tumor targets, disruption of ERα-mediated signaling, is believed to be the mechanistic mode of action for all hormonal interventions used in treating this disease. Whereas ERαis widely accepted as the single most important predictive factor (for response to endocrine therapy), the presence of the receptor in tumor cells is also of prognostic value. Even though the clinical relevance of the two other sex hormone receptors, namely, E

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10

Villablanca, Amparo C., Muthuvel Jayachandran, and Carole Banka. "Atherosclerosis and sex hormones: current concepts." Clinical Science 119, no. 12 (September 1, 2010): 493–513. http://dx.doi.org/10.1042/cs20100248.

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CVD (cardiovascular disease) is the leading cause of death for women. Considerable progress has been made in both our understanding of the complexities governing menopausal hormone therapy and our understanding of the cellular and molecular mechanisms underlying hormone and hormone receptor function. Understanding the interplay of atherosclerosis and sex steroid hormones and their cognate receptors at the level of the vessel wall has important ramifications for clinical practice. In the present review, we discuss the epidemiology of CVD in men and women, the clinical impact of sex hormones on

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11

Hillerns, Pablo Ibieta, Yuangang Zu, and Michael Wink. "Binding of Phytoestrogens to Rat Uterine Estrogen Receptors and Human Sex Hormone-binding Globulins." Zeitschrift für Naturforschung C 60, no. 7-8 (August 1, 2005): 649–56. http://dx.doi.org/10.1515/znc-2005-7-823.

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The interaction of phytoestrogens with the most important binding sites of steroid hormones, i.e. sex hormone-binding globulin and estrogen receptors, was investigated. Relative binding affinities and association constants for 21 compounds among them isoflavones, flavones, flavonols, flavanones, chalcones and lignans were determined. The lignan nordihydroguaiaretic acid weakly displaced 17β-[3H]-estradiol from estrogen receptor and Scatchard analysis suggests non-conformational changes. Compounds from Glycyrrhiza glabra, liquiritigenin and isoliquiritigenin, showed estrogenic affinities to bot

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12

Shen, Minqian, and Haifei Shi. "Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis." International Journal of Endocrinology 2015 (2015): 1–12. http://dx.doi.org/10.1155/2015/294278.

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The liver is one of the most essential organs involved in the regulation of energy homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated with imbalance between lipid formation and breakdown, glucose production and catabolism, and cholesterol synthesis and secretion. Epidemiological studies show sex difference in the prevalence in fatty liver disease and suggest that sex hormones may play vital roles in regulating hepatic steatosis. In this review, we summarize current literature and discuss the role of estrogens and androgens and the mechanisms through whic

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13

Ziller, Nadja, Roland Kotolloshi, Mohsen Esmaeili, Marita Liebisch, Ralf Mrowka, Aria Baniahmad, Thomas Liehr, Gunter Wolf та Ivonne Loeffler. "Sex Differences in Diabetes- and TGF-β1-Induced Renal Damage". Cells 9, № 10 (3 жовтня 2020): 2236. http://dx.doi.org/10.3390/cells9102236.

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While females are less affected by non-diabetic kidney diseases compared to males, available data on sex differences in diabetic nephropathy (DN) are controversial. Although there is evidence for an imbalance of sex hormones in diabetes and hormone-dependent mechanisms in transforming growth factor β1 (TGF-β1) signaling, causes and consequences are still incompletely understood. Here we investigated the influence of sex hormones and sex-specific gene signatures in diabetes- and TGF-β1-induced renal damage using various complementary approaches (a db/db diabetes mouse model, ex vivo experiments

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14

Freedman, Robert R., and Rachael Baer. "Sex Hormones Modulate Peripheral Vascular Adrenergic Receptors." Menopause 3, no. 4 (1996): 225. http://dx.doi.org/10.1097/00042192-199603040-00035.

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15

Venken, K., F. Callewaert, S. Boonen, and D. Vanderschueren. "Sex hormones, their receptors and bone health." Osteoporosis International 19, no. 11 (April 5, 2008): 1517–25. http://dx.doi.org/10.1007/s00198-008-0609-z.

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16

HILPERT, Jan, Henrik VORUM, Regina BURMEISTER, Robert SPOELGEN, Irina GRISHKOVSKAYA, Rolf MISSELWITZ, Anders NYKJAER, and Thomas E. WILLNOW. "Efficient eukaryotic expression system for authentic human sex hormone-binding globulin." Biochemical Journal 360, no. 3 (December 10, 2001): 609–15. http://dx.doi.org/10.1042/bj3600609.

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Sex hormone-binding globulin (SHBG) is the main carrier for androgens and oestrogens in humans. It mediates the transport of steroid hormones in the circulation and testicular fluid, and regulates their bioavailability to steroid-responsive tissues. In addition, the protein interacts with membrane receptors expressed in target tissues. Binding to the receptors is suspected to facilitate the uptake of steroid hormones and/or elicit cellular signal transduction. The identity of the SHBG receptor has not yet been resolved, in part due to a lack of sufficient quantities of authentic SHBG for recep

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17

Shramko, S. V., L. F. Gulyaeva, V. N. Zorina, and T. V. Tretyakova. "Proliferative diseases of the uterus: clinical, immunological, and molecular aspects." Voprosy ginekologii, akušerstva i perinatologii 19, no. 5 (2020): 13–21. http://dx.doi.org/10.20953/1726-1678-2020-5-13-21.

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Objective. To perform comparative analysis of clinical data, serum levels of acute-phase proteins, cytokines, steroid hormones, and expression of genes encoding sex hormone receptors in tissues of patients with proliferative diseases of the uterus. Patients and methods. We analyzed clinical data of 349 patients with various proliferative diseases of the uterus. We also evaluated their serum levels of α2-macroglobulin, pregnancy-associated α2-glycoprotein, their immunocomplexes with IgG, lactoferrin, VEGF, IL-6, TNFa, IL-8, and sex hormones. Uterine tissue samples were tested for the expression

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18

Mariotti, Angelo. "Sex Steroid Hormones and Cell Dynamics in the Periodontium." Critical Reviews in Oral Biology & Medicine 5, no. 1 (January 1994): 27–53. http://dx.doi.org/10.1177/10454411940050010201.

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The biological changes that occur in tissues of the periodontium during puberty, the menstrual cycle, pregnancy, menopause, and oral contraceptive use have heightened interest in the relationship between sex steroid hormones and periodontal health. These clinical observations coupled with tissue specificity of hormone localization, identification of hormone receptors, as well as the metabolism of hormones have strongly suggested that periodontal tissues are targets for androgens, estrogens, and progestins. The etiologies of periodontal endocrinopathies are diverse; nonetheless, periodontal pat

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19

Regitz-Zagrosek, Vera, and Georgios Kararigas. "Mechanistic Pathways of Sex Differences in Cardiovascular Disease." Physiological Reviews 97, no. 1 (January 2017): 1–37. http://dx.doi.org/10.1152/physrev.00021.2015.

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Major differences between men and women exist in epidemiology, manifestation, pathophysiology, treatment, and outcome of cardiovascular diseases (CVD), such as coronary artery disease, pressure overload, hypertension, cardiomyopathy, and heart failure. Corresponding sex differences have been studied in a number of animal models, and mechanistic investigations have been undertaken to analyze the observed sex differences. We summarize the biological mechanisms of sex differences in CVD focusing on three main areas, i.e., genetic mechanisms, epigenetic mechanisms, as well as sex hormones and thei

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20

Sherwood, Nancy M., Bruce A. Adams, and Javier A. Tello. "Endocrinology of protochordates." Canadian Journal of Zoology 83, no. 1 (January 1, 2005): 225–55. http://dx.doi.org/10.1139/z04-178.

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Large-scale gene duplications occurred early in the vertebrate lineage after the split with protochordates. Thus, protochordate hormones and their receptors, transcription factors, and signaling pathways may be the foundation for the endocrine system in vertebrates. A number of hormones have been identified including cionin, a likely ancestor of cholecytokinin (CCK) and gastrin. Both insulin and insulin-like growth hormone (IGF) have been identified in separate cDNAs in a tunicate, whereas only a single insulin-like peptide was found in amphioxus. In tunicates, nine distinct forms of gonadotro

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21

Vegeto, Elisabetta, Alessandro Villa, Sara Della Torre, Valeria Crippa, Paola Rusmini, Riccardo Cristofani, Mariarita Galbiati, Adriana Maggi, and Angelo Poletti. "The Role of Sex and Sex Hormones in Neurodegenerative Diseases." Endocrine Reviews 41, no. 2 (September 23, 2019): 273–319. http://dx.doi.org/10.1210/endrev/bnz005.

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Abstract Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous system (CNS) with unknown etiology. Several factors were hypothesized to be involved in the pathogenesis of these diseases, including genetic and environmental factors. Many of these diseases show a sex prevalence and sex steroids were shown to have a role in the progression of specific forms of neurodegeneration. Estrogens were reported to be neuroprotective through their action on cognate nuclear and membrane receptors, while adverse effects of male hormones have been described on neuronal cells, a

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22

Yamashina, Masahiro, Takahiro Tsutsui, Yoshihisa Sei, Munetaka Akita, and Michito Yoshizawa. "A polyaromatic receptor with high androgen affinity." Science Advances 5, no. 4 (April 2019): eaav3179. http://dx.doi.org/10.1126/sciadv.aav3179.

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Biological receptors distinguish and bind steroid sex hormones, e.g., androgen-, progestogen-, and estrogen-type hormones, with high selectivity. To date, artificial molecular receptors have been unable to discriminate between these classes of biosubstrates. Here, we report that an artificial polyaromatic receptor preferentially binds a single molecule of androgenic hormones, known as “male” hormones (indicated with m), over progestogens and estrogens, known as “female” hormones (indicated with f), in water. Competitive experiments established the binding selectivity of the synthetic receptor

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23

Meikle, A., C. Tasende, C. Sosa, and E. G. Garófalo. "The role of sex steroid receptors in sheep female reproductive physiology." Reproduction, Fertility and Development 16, no. 4 (2004): 385. http://dx.doi.org/10.1071/rd04036.

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Cell responsiveness to steroid hormones is related to the number and affinity of its receptors, thus factors affecting steroid expression will influence tissue sensitivity and functionality. The present review discusses the role of oestrogen and progesterone receptors in sheep female reproductive physiology. The mechanism of steroid hormone action in the target cell is introduced first; the tissue distribution, physiological functions and regulation of oestrogen receptor subtypes and progesterone receptor isoforms in ruminants are reported. The role of steroid receptors in target tissues (with

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Mukudai, Shigeyuki, Ken Ichi Matsuda, Takeshi Nishio, Yoichiro Sugiyama, Hideki Bando, Ryuichi Hirota, Hirofumi Sakaguchi, Yasuo Hisa, and Mitsuhiro Kawata. "Differential Responses to Steroid Hormones in Fibroblasts From the Vocal Fold, Trachea, and Esophagus." Endocrinology 156, no. 3 (March 1, 2015): 1000–1009. http://dx.doi.org/10.1210/en.2014-1605.

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Abstract There is accumulating evidence that fibroblasts are target cells for steroids such as sex hormones and corticoids. The characteristics of fibroblasts vary among tissues and organs. Our aim in this study is to examine differences in responses to steroid hormones among fibroblasts from different cervicothoracic regions. We compared the actions of steroid hormones on cultured fibroblasts from the vocal folds, which are considered to be the primary target of steroid hormones, and the trachea and esophagus in adult male rats. Expression of steroid hormone receptors (androgen receptor, estr

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25

Ayakannu, Thangesweran, Anthony H. Taylor, Timothy H. Marczylo, Jonathon M. Willets, and Justin C. Konje. "The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers." International Journal of Endocrinology 2013 (2013): 1–14. http://dx.doi.org/10.1155/2013/259676.

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The “endocannabinoid system (ECS)” comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport system. Recent evidence suggests that both cannabinoid receptors are present in sex steroid hormone-dependent cancer tissues and potentially play an important role in those malignancies. Sex steroid hormones regulate the endocannabinoid system and the endocannabinoids prevent tumour development through putative protective mechanisms that prevent

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Norstedt, G., B. Husman, A. Mode, P. Eneroth, U. J. Lewis, and J. Å. Gustafsson. "Induction of prolactin receptors in the liver is more closely related to the growth-promoting than to the lactogenic potency of peptides." Acta Endocrinologica 114, no. 3 (March 1987): 350–56. http://dx.doi.org/10.1530/acta.0.1140350.

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Abstract. The sex differentiated binding 125I-human prolactin (PRL) to rat liver membranes was studied and the present results extend our previous studies on induction of hepatic PRL receptors by growth hormone (GH). In prepubertal female rats, PRL receptor levels are low compared with those in mature female rat livers. Infusion of hGH during one week to 17-day-old female rats resulted in a receptor level typical of adult female rats. The time course of receptor disappearance in male rats treated with hGH was also studied. When the receptor-inducing hormone was removed, receptor levels in hGH-

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Ismail, Ahmed, Katarzyna Anna Mierzejewska, Anna Janowska-Wieczorek, A. Robert Turner, Mariusz Z. Ratajczak, and Magdalena Kucia. "Novel Evidence That Pituitary Gonadotropins Directly Stimulate Human Leukemic cells—studies on Myeloid Cell Lines and Primary Patient AML and CML Cells." Blood 124, no. 21 (December 6, 2014): 2204. http://dx.doi.org/10.1182/blood.v124.21.2204.2204.

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Abstract Background . It has been postulated that hematopoietic stem/progenitor cells (HSPCs) can become specified from a population of migrating primordial germ cells (PGCs) isolated from embryos. In support of this intriguing possibility, HSPCs and PGCs are both highly migratory populations of stem cells, and evidence has accumulated for the sharing of several mutated genes (e.g., Sall4) as well as chromosomal aberrations between germline tumors and leukemias or lymphomas, which suggests their common clonal origin. In fact, we recently observed that normal murine HSPCs express several functi

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Wierman, Margaret E. "Sex steroid effects at target tissues: mechanisms of action." Advances in Physiology Education 31, no. 1 (January 2007): 26–33. http://dx.doi.org/10.1152/advan.00086.2006.

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Our understanding of the mechanisms of sex hormone action has changed dramatically over the last 10 years. Estrogens, progestins, and androgens are the steroid hormones that modulate reproductive function. Recent data have shown that many other tissues are targets of sex hormones in addition to classical reproductive organs. This review outlines new advances in our understanding of the spectrum of steroid hormone ligands, newly recognized target tissues, structure-function relationships of steroid receptors, and, finally, their genomic and nongenomic actions. Sex-based specific effects are oft

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Kur, Paulina, Agnieszka Kolasa-Wołosiuk, Kamila Misiakiewicz-Has, and Barbara Wiszniewska. "Sex Hormone-Dependent Physiology and Diseases of Liver." International Journal of Environmental Research and Public Health 17, no. 8 (April 11, 2020): 2620. http://dx.doi.org/10.3390/ijerph17082620.

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Sexual dimorphism is associated not only with somatic and behavioral differences between men and women, but also with physiological differences reflected in organ metabolism. Genes regulated by sex hormones differ in expression in various tissues, which is especially important in the case of liver metabolism, with the liver being a target organ for sex hormones as its cells express estrogen receptors (ERs: ERα, also known as ESR1 or NR3A; ERβ; GPER (G protein-coupled ER, also known as GPR 30)) and the androgen receptor (AR) in both men and women. Differences in sex hormone levels and sex hormo

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García-Gómez, Elizabeth, Bertha González-Pedrajo, and Ignacio Camacho-Arroyo. "Role of Sex Steroid Hormones in Bacterial-Host Interactions." BioMed Research International 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/928290.

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Sex steroid hormones play important physiological roles in reproductive and nonreproductive tissues, including immune cells. These hormones exert their functions by binding to either specific intracellular receptors that act as ligand-dependent transcription factors or membrane receptors that stimulate several signal transduction pathways. The elevated susceptibility of males to bacterial infections can be related to the usually lower immune responses presented in males as compared to females. This dimorphic sex difference is mainly due to the differential modulation of the immune system by se

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Vermeirsch, Hilde, Wim Van Den Broeck, Mark Coryn, and Paul Simoens. "Immunolocalization of sex steroid hormone receptors in the canine uterine tube and their relation to sex steroid hormone levels." Reproduction, Fertility and Development 14, no. 4 (2002): 241. http://dx.doi.org/10.1071/rd01084.

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The aim of this immunohistochemical study was to describe the cellular distribution of the estrogen receptor-α (ERα), progesterone receptor (PR) and androgen receptor (AR) in canine uterine tubes. Samples of uterine tubes were taken from dogs in different stages of the estrous cycle, and dogs that were pregnant or had just delivered. Nuclear staining for sex steroid hormone receptors was observed in the surface epithelium, stromal cells and smooth muscle cells of the muscular layer. Only slight differences in staining pattern were observed between the ampulla and fimbriae. The staining for ERα

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Nagasue, Naofumi, and Hitoshi Kohno. "Hepatocellular Carcinoma and Sex Hormones." HPB Surgery 6, no. 1 (January 1, 1992): 1–6. http://dx.doi.org/10.1155/1992/72761.

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The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives and androgenic steroids can induce benign and malignant hepatocellular tumors. Hepatocellular carcinoma (HCC) is more prevalent in men than in women. The role of sex hormones and their receptors in the development of HCC was reviewed. Some HCCs may be androgen dependent but others may be estrogen or even both dependent. Further studies are mandatory in order to utilize such characteristics of HCC for an effective prophylaxis and therapy of this tumor.

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Dzieciuchowicz, L., M. Kotwicka, M. Gabriel, A. Szczęśniak-Chmielecka, B. Krasińska, G. Oszkinis, W. Majewski, and Z. Krasiński. "Sex hormone receptors in varicose veins of women with premenstrual syndrome." Phlebologie 37, no. 02 (March 2008): 68–72. http://dx.doi.org/10.1055/s-0037-1622215.

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SummaryThe pathogenesis of premenstrual tension syndrome is not fully understood. It has been hypothesized that the interaction between sex hormones and target organs is the key event in its pathogenesis. Aim: The purpose of the study was to examine the differences in the prevalence of smooth muscle cells with sex hormones receptors in varicose veins of women with and without premenstrual tension syndrome (PS). Patients, methods: Samples of great saphenous vein were obtained from 50 women during varicose vein surgery. They were divided into group I (20 women with clinically diagnosed PS) and g

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Dou, Mengmeng, Keyan Zhu, Zhirui Fan, Yuxuan Zhang, Xiufang Chen, Xueliang Zhou, Xianfei Ding, et al. "Reproductive Hormones and Their Receptors May Affect Lung Cancer." Cellular Physiology and Biochemistry 44, no. 4 (2017): 1425–34. http://dx.doi.org/10.1159/000485538.

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Background/Aims: In contrast to men, women have experienced a rapid increase in lung cancer mortality. Numerous studies have found that the sex differences in lung cancer are due to reproductive hormones. Experiments in female mice with and without ovariectomy were performed to explore the possible mechanism by which sex hormones (and their receptors) influence lung cancer. Methods: Twenty-four female C57BL/6 mice aged 56-62 days were randomly divided into the ovariectomized group and the control group. In the ovariectomized group, the bilateral ovaries were removed via the dorsal approach, wh

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Honda, Shozo, Phillipe Loher, Megumi Shigematsu, Juan P. Palazzo, Ryusuke Suzuki, Issei Imoto, Isidore Rigoutsos, and Yohei Kirino. "Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers." Proceedings of the National Academy of Sciences 112, no. 29 (June 29, 2015): E3816—E3825. http://dx.doi.org/10.1073/pnas.1510077112.

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Sex hormones and their receptors play critical roles in the development and progression of the breast and prostate cancers. Here we report that a novel type of transfer RNA (tRNA)-derived small RNA, termed Sex HOrmone-dependent TRNA-derived RNAs (SHOT-RNAs), are specifically and abundantly expressed in estrogen receptor (ER)-positive breast cancer and androgen receptor (AR)-positive prostate cancer cell lines. SHOT-RNAs are not abundantly present in ER− breast cancer, AR− prostate cancer, or other examined cancer cell lines from other tissues. ER-dependent accumulation of SHOT-RNAs is not limi

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Amenyogbe, Eric, Gang Chen, Zhongliang Wang, Xiaoying Lu, Mingde Lin, and Ai Ying Lin. "A Review on Sex Steroid Hormone Estrogen Receptors in Mammals and Fish." International Journal of Endocrinology 2020 (February 7, 2020): 1–9. http://dx.doi.org/10.1155/2020/5386193.

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Steroid hormones play essential roles in the reproductive biology of vertebrates. Estrogen exercises its effect through estrogen receptors and is not only a female reproductive hormone but acts virtually in all vertebrates, including fish, and is involved in the physiological and pathological states in all males and females. Estrogen has been implicated in mandible conservation and circulatory and central nervous systems as well as the reproductive system. This review intended to understand the structure, function, binding affinities, and activations of estrogens and estrogen receptors and to

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McEwan, Iain J. "Sex, drugs and gene expression: signalling by members of the nuclear receptor superfamily." Essays in Biochemistry 40 (June 1, 2004): 1–10. http://dx.doi.org/10.1042/bse0400001.

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It is almost 20 years since the first steroid receptor cDNAs were cloned, a development that led to the concept of a superfamily of ligand-activated transcription factors: the nuclear receptors. Natural ligands for nuclear receptors are generally lipophilic in nature and include steroid hormones, bile acids, fatty acids, thyroid hormones, certain vitamins and prostaglandins. Nuclear receptors act principally to directly control patterns of gene expression and play vital roles during development and in the regulation of metabolic and reproductive functions in the adult organism. Since the origi

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Chang, Ya-Ting, Yung-Lung Chen, and Hong-Yo Kang. "Revealing the Influences of Sex Hormones and Sex Differences in Atrial Fibrillation and Vascular Cognitive Impairment." International Journal of Molecular Sciences 22, no. 16 (August 16, 2021): 8776. http://dx.doi.org/10.3390/ijms22168776.

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The impacts of sex differences on the biology of various organ systems and the influences of sex hormones on modulating health and disease have become increasingly relevant in clinical and biomedical research. A growing body of evidence has recently suggested fundamental sex differences in cardiovascular and cognitive function, including anatomy, pathophysiology, incidence and age of disease onset, symptoms affecting disease diagnosis, disease severity, progression, and treatment responses and outcomes. Atrial fibrillation (AF) is currently recognized as the most prevalent sustained arrhythmia

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Brun, Claire, Jean-Marie Exbrayat, and Michel Raquet. "Localization of Receptors for Sex Steroids and Pituitary Hormones in the Female Genital Duct throughout the Reproductive Cycle of a Viviparous Gymnophiona Amphibian, Typhlonectes compressicauda." Animals 11, no. 1 (December 22, 2020): 2. http://dx.doi.org/10.3390/ani11010002.

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Reproduction in vertebrates is controlled by the hypothalamo-pituitary-gonadal axis, and both the sex steroid and pituitary hormones play a pivotal role in the regulation of the physiology of the oviduct and events occurring within the oviduct. Their hormonal actions are mediated through interaction with specific receptors. Our aim was to locate α and β estrogen receptors, progesterone receptors, gonadotropin and prolactin receptors in the tissues of the oviduct of Typhlonectes compressicauda (Amphibia, Gymnophiona), in order to study the correlation between the morphological changes of the ge

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Fuentes, Nathalie, and Patricia Silveyra. "Endocrine regulation of lung disease and inflammation." Experimental Biology and Medicine 243, no. 17-18 (December 2018): 1313–22. http://dx.doi.org/10.1177/1535370218816653.

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Sex-based disparities have been identified in respiratory physiology, and in many chronic lung diseases including asthma, chronic obstructive pulmonary disease, and cystic fibrosis. The observed sex differences in lung disease prevalence and incidence have been linked to changes in circulating levels of sex hormones that start after puberty and that have been shown to affect physiological and immunological functions. While the exact roles of male and female sex hormones in these processes have not been fully elucidated, it is now evident that these can target many lung cell types and affect se

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Celayir, Sinan. "Is there a `bladder sex'? The relation of different sex hormones and sex hormone receptors in bladder in childhood." Medical Hypotheses 59, no. 2 (August 2002): 186–90. http://dx.doi.org/10.1016/s0306-9877(02)00245-1.

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Dahir, Naima S., Ashley N. Calder, Blake J. McKinley, Yan Liu, and Timothy A. Gilbertson. "Sex differences in fat taste responsiveness are modulated by estradiol." American Journal of Physiology-Endocrinology and Metabolism 320, no. 3 (March 1, 2021): E566—E580. http://dx.doi.org/10.1152/ajpendo.00331.2020.

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Using molecular, cellular, and behavioral analyses, this study shows that sex differences occur in fat taste in a mouse model. Female mice are more responsive to fatty acids, leading to an overall decrease in intake and fatty acid preference. These differences are linked to sex hormones, as estradiol enhances taste cell responsiveness to fatty acids during periods of low circulating estrogen following ovariectomy and in males. Estradiol is ineffective in altering fatty acid signaling during a high-estrogen period and in ovariectomized mice on hormone replacement. Thus, taste receptor cells are

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Vermeirsch, Hilde, Wim Van Den Broeck, and Paul Simoens. "Immunolocalization of sex steroid hormone receptors in canine vaginal and vulvar tissue and their relation to sex steroid hormone levels." Reproduction, Fertility and Development 14, no. 4 (2002): 251. http://dx.doi.org/10.1071/rd01088.

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The aim of this immunohistochemical study was to describe the cellular distribution of the estrogen receptor-α (ERα), progesterone receptor (PR) and androgen receptor (AR) in canine vaginal and vulvar tissue. Samples were taken from dogs in different stages of the estrous cycle. Nuclear staining for ERα, PR and AR was observed in surface epithelium, stromal and smooth muscle cells. Receptors were also expressed in vulvar skin. Cytoplasmic staining for AR was observed in basal and parabasal cell layers of vulvar and vaginal epithelium. For all three receptors, staining intensity was generally h

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Luo, Sheng-Dean, Tai-Jan Chiu, Wei-Chih Chen, and Ching-Shuen Wang. "Sex Differences in Otolaryngology: Focus on the Emerging Role of Estrogens in Inflammatory and Pro-Resolving Responses." International Journal of Molecular Sciences 22, no. 16 (August 16, 2021): 8768. http://dx.doi.org/10.3390/ijms22168768.

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Otolaryngology (also known as ear, nose, and throat (ENT)) diseases can be significantly affected by the level of sex hormones, which indicates that sex differences affect the manifestation, pathophysiology, and outcomes of these diseases. Recently, increasing evidence has suggested that proinflammatory responses in ENT diseases are linked to the level of sex hormones. The sex hormone receptors are present on a wide variety of immune cells; therefore, it is evident that they play crucial roles in regulating the immune system and hence affect the disease progression of ENT diseases. In this rev

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Mierzejewska, Kasia, Ewa Suszynska, Sylwia Borkowska, Malwina Suszynska, Maja Maj, Janina Ratajczak, Magdalena Kucia, and Mariusz Z. Ratajczak. "Novel In Vivo Evidence That Not Only Androgens But Also Pituitary Gonadotropins and Prolactin Directly Stimulate Murine Bone Marrow Stem Cells – Implications For Potential Treatment Strategies In Aplastic Anemias." Blood 122, no. 21 (November 15, 2013): 2476. http://dx.doi.org/10.1182/blood.v122.21.2476.2476.

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Abstract Background Hematopoietic stem/progenitor cells (HSPCs) are exposed in vivo to several growth factors, cytokines, chemokines, and bioactive lipids in bone marrow (BM) in addition to various sex hormones circulating in peripheral blood (PB). It is known that androgen hormones (e.g., danazol) is employed in the clinic to treat aplastic anemia patients. However, the exact mechanism of action of sex hormones secreted by the pituitary gland or gonads is not well understood. Therefore, we performed a complex series of experiments to address the influence of pregnant mare serum gonadotropin (

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Liu, RenHui, Xue Kang, LiPing Xu, HongLei Nian, XinWei Yang, HaoTian Shi, and XiuJuan Wang. "Effect of the Combined Extracts of Herba Epimedii and Fructus Ligustri Lucidi on Sex Hormone Functional Levels in Osteoporosis Rats." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/184802.

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The combination of Herba Epimedii and Fructus Ligustri Lucidi has been used to treat osteoporosis for almost 50 years by Professor Shizeng Li, a famous doctor of traditional Chinese medicine (TCM). However, it is unclear whether the combination of the effective constituents of the two herbs may have a protective influence on the skeleton. In the present study, we investigated the effects of the combination extracts of Herba Epimedii and Fructus Ligustri Lucidi on rat model of osteoporosis induced by retinoic acid by gavage. With administrations of the combination extracts of the two herbs (50,

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Nasser, Suzanne A., Elham A. Afify, Firas Kobeissy, Bassam Hamam, Ali H. Eid, and Mahmoud M. El-Mas. "Inflammatory Basis of Atherosclerosis: Modulation by Sex Hormones." Current Pharmaceutical Design 27, no. 18 (June 24, 2021): 2099–111. http://dx.doi.org/10.2174/1381612827666210122142811.

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Atherosclerosis-related cardiovascular diseases (CVDs) are the leading cause of death globally. Several lines of evidence are supportive of the contributory role of vascular inflammation in atherosclerosis. Diverse immune cell types, including monocytes/macrophages, T-cells and neutrophils, as well as specialized proresolving lipid mediators, have been successfully characterized as key players in vascular inflammation. The increased prevalence of atherosclerotic CVD in men in comparison to age-matched premenopausal women and the abolition of sex differences in prevalence during menopause stron

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Babichev, V. N., Ye L. Adamskaya, and T. A. Peryshkova. "Analysis of hypothalamo-hypophyseo-gonadal relationships in female rats with experimental diabetes." Problems of Endocrinology 40, no. 1 (February 15, 1994): 46–50. http://dx.doi.org/10.14341/probl11334.

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Hypothalamo-hypophyseo-gonadal system functional activity was studied in rats with streptozotocin diabetes. In intact rats concentrations of sex hormones nuclear receptors were measured in the hypothalamic preopticoanterior, mediobasal segments and in the adenohypophysis, as were blood serum gonadotropins and sex hormones. Estradiol and progesterone were injected to ovariectomized females and LH-RH levels measured in preopticoanterior segment of the hypothalamus, arcuate nucleus, and median eminence, as well as LH and FSH concentrations in the blood in order to detect disorders in basal and cy

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Nacci, Andrea, Bruno Fattori, Fabio Basolo, Maria E. Filice, Katia De Jeso, Luca Giovannini, Luca Muscatello, Fabio Matteucci, and Francesco Ursino. "Sex Hormone Receptors in Vocal Fold Tissue: A Theory about the Influence of Sex Hormones in the Larynx." Folia Phoniatrica et Logopaedica 63, no. 2 (2011): 77–82. http://dx.doi.org/10.1159/000316136.

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Harvey, Brian J., Steven Condliffe, and Christina M. Doolan. "Sex and Salt Hormones: Rapid Effects in Epithelia." Physiology 16, no. 4 (August 2001): 174–77. http://dx.doi.org/10.1152/physiologyonline.2001.16.4.174.

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Recent evidence points to protein kinase C isoforms as highly specific receptors for aldosterone and estradiol in epithelia. The end targets of the kinase activation are Na+/H+ exchange and K+ and Ca2+ channels. The physiological role of the nongenomic response is to increase electrolyte absorption and inhibit secretion in pluripotential epithelia.

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