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Rozprawy doktorskie na temat „Human herpesvirus type 7”

Autor: Grafiati

Data publikacji: 3 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Li, Cheryl Suet-Yee. "Viral and host gene expression patterns in human herpesvirus type-7 infection of T-cells." Thesis, University College London (University of London), 2005. http://discovery.ucl.ac.uk/1445736/.

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Human herpesvirus type 7 (HHV-7), with its high prevalence and apparently non pathogenic nature, is believed to be a virus very well adapted to humans. It is therefore useful to study the transcription patterns of the virus and the host to understand the life cycle and pathogenesis (or the lack of it) of HHV-7 infection. In order to obtain the global pattern of host and viral gene expression, we have made a DNA microarray containing probes that target all 86 predicted HHV-7 open reading frames and approximately 1000 cellular genes. This is the first description of an integrated host- pathogen

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2

Kidd, Ian Michael. "Human cytomegalovirus, human herpesvirus 6 and human herpesvirus 7 infection of the immunocompromised host." Thesis, University College London (University of London), 1997. http://discovery.ucl.ac.uk/1453654/.

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Parola, Daniela Corte. "Herpesvirus humano 5,6 e 7 (HHV-5, HHV-6 e HHV-7) em receptores de transplantes de medula ossea." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311928.

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Orientador: Sandra Cecilia Botelho Costa<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-09T12:05:48Z (GMT). No. of bitstreams: 1 Parola_DanielaCorte_M.pdf: 2987280 bytes, checksum: 06dcaf150379c56fac854a42d4bc3453 (MD5) Previous issue date: 2007<br>Resumo: O membro protótipo da subfamília dos betaherpesvírus, o citomegalovírus humano (HCMV), é o patógeno mais importante em pacientes transplantados, incluindo aqueles que receberam células de medula óssea ou enxerto de células tronco. Testes diagnósticos para

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4

Thomasini, Ronaldo Luís 1978. "Detecção e monitorização do Herpesvirus humano 7 (HHV-7) em transplantados hepaticos : impacto clinico e associação com Citomegalovirus e Herpesvirus humano 6." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311931.

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Orientador: Sandra Cecilia Botelho Costa<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-08T20:07:57Z (GMT). No. of bitstreams: 1 Thomasini_RonaldoLuis_M.pdf: 1552471 bytes, checksum: 69e020e777011a1dab1c773d2466694a (MD5) Previous issue date: 2007<br>Resumo: Neste estudo, 29 pacientes adultos, transplantados de fígado foram monitorados (até 180 dias pós-transplante) para infecções ativas por HCMV, HHV-6 e HHV-7 usando Nested-PCR (N-PCR). O protocolo de imunossupressão foi baseado na combinação de esteróides

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5

Thomasini, Ronaldo Luís 1978. "Citomegalovírus, herpesvírus humano 6, herpesvírus humano 7 e perfil imunofenotípico do infiltrado inflamatório na periodontite crônica marginal." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311940.

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Orientador: Sandra Cecília Botelho Costa<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T10:22:52Z (GMT). No. of bitstreams: 1 Thomasini_RonaldoLuis_D.pdf: 2991233 bytes, checksum: 570abfb75508069faffb192f2c6c5dcd (MD5) Previous issue date: 2011<br>Resumo: Periodontite humana crônica é um processo inflamatório caracterizado por denso acúmulo de células imunes no tecido periodontal. A periodontite pode levar a perda do dente no paciente e a patogênese desta doença não é completamente conhecida. Este estudo testou

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6

Tait, Andrew Robert. "Isolation and characterization of recombinant U24, a membrane protein from human herpesvirus type 6." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36585.

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This thesis describes the isolation and characterization of the U24 membrane protein encoded by Human Herpesvirus type-6 (HHV-6), obtained from an E. coli recombinant expression system. HHV-6 infection has been previously associated with the disease multiple sclerosis (MS), and the U24 protein is of interest because it has a seven amino-acid sequence (PRTPPPS) identical to myelin basic protein (MyBP), a candidate auto-antigen in MS. In the first part of this thesis, I describe the methods that were developed to enable milligram quantities of U24 to be isolated and purified from litre culture

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7

Smith, Danielle Claire. "Spinocerebellar ataxia type 7 in southern africa: an epidemiological, molecular and cellular study." Doctoral thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/13022.

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Includes bibliographical references.<br>Spinocerebellar ataxia type 7 (SCA7) is an inherited neurodegenerative disease caused by a pathogenic expansion of a CAG repeat within the ataxin 7 gene, resulting in an expanded polyglutamine tract in the ATXN7 protein. SCA7 patients suffer from selective degeneration of cerebellar Purkinje neurons and retinal photoreceptors, which leads to the development of various neurological symptoms, and blindness. SCA7 is considered to be a relatively rare disease, but South Africa has an increased prevalence of the SCA7 due to a founder effect within the black A

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8

Loiacono, Christina Marie. "Mechanism of herpes simplex virus type 1 latency in transgenic mouse models." MU has, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3052194.

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9

Faro, Eduardo Salustino. "Epidemiologia molecular do herpesvírus humano tipo 6 (HHV-6) em crianças recém-nascidas e suas respectivas mães." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/87/87131/tde-06012009-162645/.

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A infecção primária com o herpesvirus humano tipo 6 (HHV-6) pode resultar no exantema súbito, encefalite e recorrentes complicações. Pesquisas demonstram que crianças obtêm os anticorpos contra o HHV-6 antes dos dois anos de idade. Após a infecção primária, o DNA do HHV-6 permanece latente em linfócitos, saliva ou líquor. A rota de transmissão permanece controversa. A liberação do HHV-6 em saliva parece ser a maior rota de transmissão. A transmissão intra-uterina, integrada no cromossomo é outra sugestão de transmissão. Foram colhidas 172 amostras, 86 de secreção cervical (mãe) e 86 de aspirad

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10

Watson, Lauren. "Novel cell models for the study of spinocerebellar ataxia type 7 pathogenesis and therapy in a South African patient cohort." Doctoral thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/3108.

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Includes abstract.<br>Includes bibliographical references.<br>Spinocerebellar ataxia type 7 (SCA7) is a dominantly-inherited neurodegenerative disease, resulting from a CAG trinucleotide repeat expansion in the ataxin-7 gene. The Ataxin-7 protein is known to play a role in transcriptional regulation through association with cellular histone acetylation complexes, and several studies have highlighted the role of transcriptional dysregulation, caused by the presence of mutant Ataxin-7, in the neuronal dysfunction that precedes the onset of disease symptoms.This study aimed to establish patient-d

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11

Jonasson, Jenni. "Genetic and Molecular analysis of the Spinocerebellar ataxia type 7 (SCA7) disease gene." Doctoral thesis, Umeå universitet, Medicinsk och klinisk genetik, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1900.

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Spinocerebellar ataxia type 7 (SCA7) is a hereditary neurodegenerative disorder affecting the cerebellum, pons and retina. SCA7 patients present with gait ataxia and visual impairment as the main symptoms. Anticipation, commonly observed in SCA7 families, is a phenomenon where an earlier age at onset and a more severe progression of disease is seen in successive generations. In order to identify the gene responsible for SCA7, we performed linkage analysis on a Swedish SCA7 kindred. Evidence for linkage of the SCA7 disease locus to a 32 cM region on chromosome 3p12-21.1, between markers D3S1547

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12

Liu, Anquan. "Proinflammatory factor mediated lymphocyte activation - the pivotal role of leukotriene B4 /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-391-7/.

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13

Vassena, Lia. "Anti-apoptotic effects of Interleukin 7 in Human Immunodeficiency Virus Type 1 infection : mechanism and implications for immune reconstitution strategies." Thesis, Open University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.552800.

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Although HAART has introduced great improvements in the clinical outcome of HIV-1- infected individuals, the current protocols often fail in completely restoring the CD4+ T-cell lymphopenia. Therefore, innovative approaches based on the use of immune adjuvants to HAART, including cytokines like IL-2, IL-15 and IL-7, are being explored. The present thesis aims at investigating the immunomodulatory effects of IL- 7 in RIV /SIV infection, focusing on its pro-survival properties. The first part of this work describes the results of a study in vitro to evaluate the effects of IL-7 on T cells from H

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14

Chang, Eddie. "The role of perforin and chemokines in the pathogenesis of chronic corneal inflammation induced by herpes simplex virus type-1 infection." free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091911.

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15

Nord, Brita. "Endocrine tumour development : with special focus on chromosome arms 1p and 11q /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-166-7.

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16

Novak, Erik Joseph. "Tracking antigen-specific immune responses in human infection and disease /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5084.

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Wawrzyniak, Ivan, and Ivan Wawrzyniak. "Génomique et post-génomique du parasite intestinal Blastocystis sp. sous-type 7. Evaluation de son pouvoir pathogène." Phd thesis, Université Blaise Pascal - Clermont-Ferrand II, 2012. http://tel.archives-ouvertes.fr/tel-00741967.

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Blastocystis spp. est un Straménopile parasite anaérobie fréquemment rencontré dans le tractus gastro-intestinal de l'homme et de divers animaux. Ce parasite est associé à des troubles gastro‐intestinaux aspécifiques, et semble impliqué dans des désordres fonctionnels tels que le syndrome de l'intestin irritable (IBS). Ce travail de thèse s'appuie sur le séquençage du génome de Blastocystis sp. ST7 réalisé en collaboration avec le Génoscope d'Evry, l'Université Nationale de Singapour, l'Institut Pasteur de Lille et l'Université de Provence. Ce génome est constitué d'un génome nucléaire de 18,8

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18

INTROINI, ANDREA. "DETERMINANTS OF HUMAN IMMUNODEFICIENCY VIRUS-1TRANSMISSION TO THE FEMALE GENITAL MUCOSA:ROLE OF CO-INFECTING PATHOGENS AND CYTOKINES IN SEMEN." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/217437.

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Background. Nel seme Human immunodeficiency virus (HIV)-1 e co-patogeni sono presenti in una complessa rete di citochine che influenza la replicazione locale e l’infettivita’ dei patogeni sessualmente trasmissibili, e, allo stesso tempo, è influenzata dalle infezioni del tratto genitale maschile (MGT). La comprensione di queste interazioni richiede un'analisi approfondita dei co-patogeni che infettano il MGT e delle citochine presenti nel liquido seminale, e delle relazioni intercorrenti tra questi e HIV-1. Metodi. La carica virale di 6 herpesvirus e HIV-1 e’ stata valutata nel plasma semina

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19

Carbone, Paulo Henrique Lage. ""Pesquisa de anticorpos dirigidos a antígenos de fase latente e lítica do herpesvírus humano tipo 8 (HHV-8): prevalência em populações sob risco epidemiológico e em população sadia de São Paulo"." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-04072003-142052/.

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O presente trabalho teve como objetivo otimizar ensaios sorológicos para serem utilizados na pesquisa de anticorpos dirigidos ao Herpesvírus humano tipo 8 (HHV-8) e com eles explorar grupos de risco para adquirir, transmitir e desenvolver doença relacionada à esta infecção, como o sarcoma de Kaposi (SK). Tomando como base a literatura disponível, as condições do laboratório e a experiência profissional acumulada na Seção de Imunologia do Instituto Adolfo Lutz de São Paulo, foram selecionados e utilizados os ensaios de imunofluorescência indireta (IFI) e Western blot (WB) para a pesquisa de ant

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20

Tartas, Cécile Viard Jean-Paul. "Pathologies liées à HHV-8 chez le patient infecté par le VIH à propos d'un cas exemplaire /." Créteil : Université de Paris-Val-de-Marne, 2006. http://doxa.scd.univ-paris12.fr:80/theses/th0236145.pdf.

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21

"Epidemiology of human herpesvirus type eight in Hong Kong." 2003. http://library.cuhk.edu.hk/record=b5891555.

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Xiao Wei.<br>Thesis submitted in: December 2002.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 95-109).<br>Abstracts in English and Chinese.<br>ABSTRACT --- p.i<br>ABSTRACT (CHINESE VERSION) --- p.iii<br>ACKNOWLEDGEMENTS --- p.v<br>TABLE OF CONTENTS --- p.vii<br>LIST OF TABLES --- p.ix<br>LIST OF FIGURES --- p.x<br>LIST OF ABBREVIATIONS --- p.xii<br>Chapter Chapter One --- Introduction --- p.1<br>Chapter 1.1 --- Discovery of HHV8 --- p.2<br>Chapter 1.2 --- Biology of HHV8 --- p.3<br>Chapter 1.2.1 --- Morphology --- p.3<br>

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22

Alagiozoglou, Pandeli (Lee). "Genetic and serologic characterization of human herpesvirus type 8 (HHV -8) IN South Africa." Thesis, 2014.

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Human herpes virus type 8 (HHV-8) is strongly implicated as the etiological agent of Kaposi’s sarcoma (KS). The incidence of KS in South Africa is increasing in parallel with the HIV-1 epidemic. Molecular and serological prevalence of HHV-8 in HIV-1 infected individuals with and without KS was investigated. DNA fragments from ORF26 (capsid, 330BAM233) and ORF75 (tegument) regions were used to determine the prevalence of HHV-8 DNA in peripheral blood mononuclear cells (PBMC) from 429 HIV-1 infected individuals, 95 of whom had histologically confirmed KS. Of those without KS, 14 (4.2%) were PGR

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Alagiozoglou, Pandeli (. Lee ). "Genetic and serologic characterization of human herpesvirus type 8 HHV-8 in South Africa." Thesis, 1999. https://hdl.handle.net/10539/26596.

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A thesis submitted to Faculty of Medicine, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the Degree of Master of Science in Medicine. Johannesburg, 1999<br>Human herpes virus type 8 ( HHv-8 ) is strongly implicated as the etiological agent of Kaposi's sarcoma ( KS ) The incidence of KS in South Africa is increasing in parallel with the HIV-! epidemic. Molecular serological prevalence of HHV-8 in HIV-1 infected individuals with and without KS was investigated. DNA fragments from ORF26 ( capsid, 330BAM 233 ) and ORF75 ( tegument ) regions were used to dete

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24

Ao, Zhujun. "Integrase, the central DNA flap and human immunodeficiency virus type 1 nuclear import." Thèse, 2006. http://hdl.handle.net/1866/15598.

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25

Koyuncu, Emre [Verfasser]. "Ubiquitin specific protease 7 plays a critical role in control of lytic infection and cell transformation by human adenovirus type 5 / vorgelegt von Emre Koyuncu." 2009. http://d-nb.info/995849668/34.

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