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Rozprawy doktorskie na temat „Human neurogenesis”

Autor: Grafiati

Data publikacji: 16 listopada 2024

Data aktualizacji: 31 lipca 2025

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Andersson, Annika. "Studies on neurogenesis in the adult human brain." Thesis, Södertörn University College, School of Life Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-3646.

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<p>Many studies on neurogenesis in adult dentate gyrus (DG) have been performed on rodents and other mammalian species, but only a few on adult human DG. This study is focusing on neurogenesis in adult human DG. To characterize the birth of cells in DG, the expression of the cell proliferation marker Ki67 was examined using immunohistochemistry. Ki67-positive labelling was indeed observed in the granular cell layer and the molecular layer of dentate gyrus and in the hilus of hippocampus, as well as in the subgranular zone (SGZ). The Ki67 positive nuclei could be divided into three groups, bas

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Yu, Chieh. "Heparan sulfate proteoglycans in human models of Neurogenesis." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/203960/1/Chieh_Yu_Thesis.pdf.

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This thesis examined cell surface glycoproteins the heparan sulfate proteoglycans, as regulators of the human nervous system and identified a number of potentially novel stem cell targets for use in treating neurological disorders. Due to the poor outcome of current stem cell transplantation therapies for brain injury and neurodegeneration, this project aimed to understand the fundamentals of human neurogenesis with implications in improving stem cell therapy, understanding brain development, and the factors mediating neurodegeneration.

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Komuro, Yutaro. "Altered adult neurogenesis in a mouse model of human tauopathy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1434743393.

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Ahmad, Ruhel [Verfasser], and Albrecht [Akademischer Betreuer] Müller. "Neurogenesis from parthenogenetic human embryonic stem cells / Ruhel Ahmad. Betreuer: Albrecht Müller." Würzburg : Universitätsbibliothek der Universität Würzburg, 2013. http://d-nb.info/1031379878/34.

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Wei, Yulei. "Genetic Knowledge-based Artificial Control over Neurogenesis in Human Cells Using Synthetic Transcription Factor Mimics." Kyoto University, 2018. http://hdl.handle.net/2433/232265.

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Garnett, Shaun. "Generating a proteomic profile of neurogenesis, through the use of human foetal neural stem cells." Doctoral thesis, Faculty of Science, 2019. http://hdl.handle.net/11427/31143.

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Introduction Neurogenesis, the development of new neurons, starts soon after the formation of the neural tube and is largely completed by birth. Development of the brain after birth is mainly reliant on the formation of new connections between surviving neurons. However, adult neurogenesis does continue in the subgranular zone of the hippocampus from quiescent adult neural stem cells. Traditionally neural stem cells were cultured as neurospheres, a heterogeneous agglomeration of neural cells at various stages of differentiation. This heterogeneity prevented accurate quantitative analysis. In 2

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Bramwell, Thomas William. "Investigations into the use of human embryonal carcinoma stem cells as a model to study dopaminergic neurogenesis." Thesis, Durham University, 2009. http://etheses.dur.ac.uk/2071/.

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Parkinson's disease in reality arises as a result of a complex series of events, however it is strongly linked to the loss of a specific cellular population of midbrain dopaminergic neurons making it a candidate for stem cell based research. Stem cells can be cultured in vitro and via asymmetric cell division possess the capacity for both self renewal and the production of differentiated derivatives. The use of specific molecules and culture conditions can be applied to promote the differentiation of them towards particular cellular fates, in turn facilitating the possibility of producing enri

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Oikari, Lotta Emilia. "Regulation of human neural stem cell fate determination by proteoglycans." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/103844/8/Lotta_Emilia_Oikari_Thesis.pdf.

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This thesis investigated how human neural stem cells are regulated, focusing specifically on heparan sulfate proteoglycans, the key proteins of the extracellular space. The findings of this study identified central roles for proteoglycans in mediating neural stem cell events, including self-renewal and differentiation. This research has improved our understanding of human stem cell and human neurogenesis biology and provided novel approaches for the development of improved neural stem cell applications, including using these cells for brain damage therapy.

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GUARNIERI, GIULIA. "Human cholinergic neurons from nucleus basalis of Meynert: a new promising tool to study pathogenetic mechanisms affecting neurogenesis." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1072770.

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The degeneration of basal forebrain cholinergic neurons within the nucleus basalis of Meynert (NBM) is responsible for the cognitive decline in neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Indeed, the major therapeutic strategies have been directed toward the cholinergic system. However, no effective therapies exist to contrast NBM cholinergic neuron loss and investigations in the field are strongly restricted by the lack of human models. Thus, the work of this thesis firstly contributed to establish and characterise a novel primary culture of c

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Pigeon, Julien. "The role of NEUROG2 T149 phosphorylation site in the developing human neocortex." Electronic Thesis or Diss., Sorbonne université, 2024. http://www.theses.fr/2024SORUS092.

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Le développement des fonctions cognitives supérieures observée au cours de l'évolution des mammifères, repose sur la capacité des progéniteurs corticaux à augmenter leur production neuronale et ainsi étendre la surface du neocortex. Chez les mammifères dit gyrencéphaliques, où la période de production neuronale est allongée, la régulation du type de division, proliférative ou neurogénique, des progéniteurs corticaux est d'autant plus importante pour garantir l'accumulation de neurones. Dans le télencéphale dorsal, à l'origine du néocortex, c'est l'articulation de la voie de signalisation Notch

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Oladimeji, Paul Babajide. "Disc 1 and neurogenesis in schizophrenia and other major psychiatric disorders : a post-mortem study of the human hippocampus." Thesis, Cranfield University, 2013. http://dspace.lib.cranfield.ac.uk/handle/1826/8620.

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Psychiatric illnesses are disorders that affect millions worldwide. Evidence from quantitative and molecular genetics analysis suggests a strong genetic component to these disorders. There is also evidence that embryonic neurodevelopment is a key period in the progression schizophrenia. The aim of the present study was to use post-mortem human hippocampus from subjects of a variety of psychiatric phenotypes to investigate neurodevelopmentally- relevant gene expression in this region of the adult human brain. Particular interest is paid to schizophrenia risk gene DISC1; it has been shown to exh

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Borsini, Alessandra. "A human in vitro model to investigate the effects of inflammation on adult hippocampal neurogenesis in the context of depression." Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/a-human-in-vitro-model-to-investigate-the-effects-of-inflammation-on-adult-hippocampal-neurogenesis-in-the-context-of-depression(0eb27c3a-a0b2-4f85-b2e7-164adea3add4).html.

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Interferon (IFN)-α treatment for hepatitis C virus (HCV) is a well-recognized clinical model for inflammation-induced depression, but the mechanisms underlying these effects are not clear. Previous data reported an alteration in peripheral levels of inflammatory and neuroplasticity markers in depressed versus non-depressed patients. There is indeed evidence for blood factors, including IFN-α, to penetrate the blood brain barrier and modulate different signalling in the brain. Using a human hippocampal progenitor cells (HPCs) model firstly I examined the damaging effects of IFN-α on neurogenesi

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Rolland, Maude. "Physiopathologie de l'infection par le cytomégalovirus sur les progéniteurs neuraux humains." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30314/document.

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L'infection congénitale par le cytomégalovirus humain (HCMV) est la première cause de séquelles acquises du système nerveux central (CNS). Elle est responsable de surdités neurosensorielles, de paralysies cérébrales ou d'anomalies neuro-développementales graves (0,1% des naissances) telles que des microcéphalies ou des anomalies de gyration. Pour étudier les effets de l'infection par le HCMV sur le développement cérébral, nous utilisons des cellules souches neurales (NSC) humaines dérivées de cellules souches embryonnaires (ES), ainsi que des coupes histologiques de cerveaux fœtaux infectés. N

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Wimmer, Ryszard. "Migration of neural stem cells during human neocortical development." Electronic Thesis or Diss., Université Paris sciences et lettres, 2024. http://www.theses.fr/2024UPSLS016.

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Chez les espèces gyrencéphaliques, et en particulier chez l'homme, la forte augmentation de la taille du néocortex est largement soutenue par une niche neurogénique élargie, la zone sous-ventriculaire externe (oSVZ). Cela est dû en grande partie à l'amplification d'une population de cellules souches neurales, les cellules gliales radiales basales (bRG, également appelées oRG). Les cellules bRG colonisent la zone sous-ventriculaire externe grâce à un mouvement dépendant de l'acto-myosine appelé translocation somale mitotique (MST). Le mécanisme moléculaire exact de la MST, la question de savoir

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Abuawad, Mohammad. "Pathological changes in Alexander disease : a comparative study in human and mice with GFAP mutations." Thesis, Sorbonne Paris Cité, 2017. http://www.theses.fr/2017USPCC296.

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La maladie d'Alexander est une maladie neurodégénérative due à des mutations hétérozygotes du gène GFAP codant le principal filament intermédiaire des astrocytes matures. Nous avons étudié l'effet des mutations GFAP dans l'hippocampe d'un patient avec AxD infantile et de deux souris knockin, l'une portant une mutation dans le rod domain (p.R85C) et l'autre dans le tail domain (p.T409I). Chez le patient, nous décrivons pour la première fois: (i) des changements morphologiques sévères des cellules GFAP+ dans la zone subgranulaire du gyrus denté, qui ont perdu la plupart de leurs processus radiau

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Carlsson, Josefine. "The affects of exercise and brain plasticity, discussed in relation to Functional oriented Music Therapy; a theoretical study." Thesis, University of Skövde, School of Humanities and Informatics, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-68.

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<p>Abstract</p><p>This essay examines which role functional oriented music therapy, which is supposed to help sensorimotor development, can have in schools and in health care. To find this out, research about what kinds of effects exercise can have on academic achievements and in recovery from brain injuries has been brought up. The research concerning academic achievements was conducted with school children; some children without difficulties, some with sensory integration problems, and some with motor skill difficulties. In addition to this, research about the brain structure superior collic

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Cao, William Sam. "Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/131.

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The risks of damage to the developing nervous system of many chemicals are not known because these studies often require costly and time-consuming multi-generational animal experiments. Pluripotent stem cell-based systems can facilitate developmental neurotoxicity studies because disturbances in nervous system development can be modeled in vitro. In this study, neurons derived from embryonal carcinoma (EC) and induced pluripotent stem (iPS) cells, were first characterized to establish their suitability for developmental neurotoxicity studies. The EC stem cell line, TERA2.cl.SP-12, was differen

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Wölfle, Martina. "Comparative analyses of the neurogenic capacity of human neuroprogenitor populations derived from neural and mesodermal tissue." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-63715.

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Rainer, Quentin. "Effets comportementaux et neurogéniques des antidépresseurs dans un nouveau modèle d'anxiété/dépression chez la Souris adulte." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00672775.

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Les pathologies dépressives se caractérisent par des symptômes hétérogènes impliquant de nombreuses régions cérébrales. L'une d'entre elles, l'hippocampe, est le siège d'un processus physiologique, appelé neurogenèse, qui, chez l'adulte, serait impliqué dans l'étiologie de la dépression et la réponse au traitement antidépresseur.L'objectif de ce travail a été d'étudier le rôle des 4 étapes du processus de neurogenèse hippocampique dans l'action des antidépresseurs dans un modèle physiopathologique de la dépression, chez la Souris adulte.

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Bayer, Ronny. "Veränderungen der adulten Neurogenese im Hippocampus von Drogenabhängigen." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-163780.

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Die Neubildung von Neuronen persistiert lebenslang in der Subgranularzellschicht des Hippocampus und der Subventrikularzone des Großhirns und wird als adulte Neuroge-nese bezeichnet. Es wird vermutet, dass diese beim erwachsenen Menschen einen rele-vanten Einfluss auf degenerative Veränderungen, verschiedene neurologische Krank-heitsbilder und auf die (Dys-)Funktion des Gedächtnisses hat. Im Tiermodell wurde eine Verringerung der Neurogenese nach chronischer Morphingabe nachgewiesen. Vorarbeiten zeigten einen Zusammenhang zwischen chronischem Heroinmissbrauch und reaktiver Astrogliose, Mikrogl

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Scordel, Chloé. "Identification des déterminants viraux et mécanismes moléculaires impliqués dans l’interférence du virus de la maladie de Borna avec la neurogenèse humaine." Thesis, Paris 11, 2014. http://www.theses.fr/2014PA114849.

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Le virus de la maladie de Borna (BDV) est un virus persistant dans le système nerveux central responsable de troubles du comportement chez l’animal et possiblement chez l’homme. En utilisant des cellules progénitrices neurales humaines, des travaux antérieurs à mon arrivée au laboratoire ont montré que BDV altère la neurogenèse humaine. Les objectifs de ma thèse étaient d’identifier les déterminants viraux responsables de cette altération et de caractériser les mécanismes moléculaires impliqués. Nous avons montré que la phosphoprotéine (P) et la nucléoprotéine (N), mais pas la protéine X, indu

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Royo, Julie. "Performances cognitives et neurogenèse au cours du vieillissement chez un primate non-humain." Thesis, Paris, Muséum national d'histoire naturelle, 2020. http://www.theses.fr/2020MNHN0001.

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La neurogenèse correspond à la capacité du cerveau à former de nouveaux neurones. Ce mécanisme permet d’induire des changements structurels et fonctionnels dans le cerveau pouvant atténuer le déclin cognitif observé avec l’âge. Cette neuroplasticité persiste à l’âge adulte mais diminue au cours de la vie. Au cours de ce travail, nous avons caractérisé l’évolution des fonctions cognitives et de la neurogenèse avec l’âge chez le Microcèbe (Microcebus murinus) qui présente des changements morphologiques, comportementaux et physiologiques similaires à ceux observés chez l’Homme au cours du vieilli

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Badsha, Farhath. "A comparative study of neocortical development between humans and great apes." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-224196.

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The neocortex is the most recently evolved part of the mammalian brain which is involved in a repertoire of higher order brain functions, including those that separate humans from other animals. Humans have evolved an expanded neocortex over the course of evolution through a massive increase in neuron number (compared to our close relatives-‐‑ the chimpanzees) in spite of sharing similar gestation time frames. So what do humans do differently compared to chimpanzees within the same time frame during their development? This dissertation addresses this question by comparing the developmental pr

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Gouazé, Alexandra. "Implication de la plasticité cérébrale hypothalamique dans la régulation de l'homéostasie énergétique chez la souris : effet d'un régime gras." Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00841824.

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L'hypothalamus joue un rôle crucial dans le contrôle de l'homéostasie énergétique. Chez l'adulte, cette zone est plastique afin de s'adapter rapidement aux pressions environnementales. Ces remodelages hypothalamiques sont perturbés lors de pathologies métaboliques comme l'obésité. Nous nous sommes demandé si un régime gras provoquant des pathologies de surcharges à long terme, provoquait des modifications rapides du réseau hypothalamique chez l'individu adulte. Pour répondre à cette question, nous avons mis en place un modèle de souris présentant une réponse homéostatique rapide à un régime gr

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Barkas, Lisa Jane. "The role of adult neurogenesis on learning and memory in humans and animals with temporal lobe epilepsy." Thesis, Open University, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664607.

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Mesial temporal lobe epilepsy (MTLE) is the most common drug resistant form of epilepsy, and is associated with progressive memory impairment. Currently there is no pharmacological means to restore memory function in these patients, making it a significant unmet therapeutic need. This research thesis shows severe impairment in spatial memory acquisition and long term retention on a virtual Morris Water Maze (MWM) task in patients who had trans-slyvian selective amagdalohippocampectomies as treatment for MTLE. This pattern of impairment was also found in patients with MTLE and with MRI positive

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Ho, Joses Wei-hao. "Functional investigation of microRNA pathways in human speech and language disorders." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:0e350300-03b0-4d0b-ba8f-6548d66494bc.

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Wahlund, Thomas. "Emotional resilience in humans as an effect of hippocampal pattern separation." Thesis, Högskolan i Skövde, Institutionen för biovetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-19925.

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Pattern separation is the means by which the brain discriminates similar experiences. It enables retrieval of individuated memories without confusing them with other memories. It is the reason one remembers where one parked the car today and does not mix it up with where one parked it previously. Adult neurogenesis refers to the ongoing production of neurons in the mature brain. One of the likely roles of adult neurogenesis in the hippocampus is facilitating pattern separation. Induced reduction of adult neurogenesis in non-human animals is associated with depression- and anxiety-like behavior

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Secolin, Rodrigo. "Aplicação de modelos estatísticos e desenvolvimento de algoritmos para estudo genético de doenças neuro-psiquiátricas." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309732.

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Orientador: Iscia Teresinha Lopes Cendes<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-17T11:06:08Z (GMT). No. of bitstreams: 1 Secolin_Rodrigo_D.pdf: 5866562 bytes, checksum: 5079bfd5d88341ce619480ba6e19fb16 (MD5) Previous issue date: 2011<br>Resumo: Fatores genéticos têm sido descritos para diversas doenças do sistema nervoso central. Uma etapa importante na identificação de genes responsáveis por estas doenças são os estudos de mapeamento genético. Além disso, devido às novas tecnologias de aquisição de dados

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Etievant, Adeline. "Stimulation du cortex préfrontal : Mécanismes neurobiologiques de son effet antidépresseur." Phd thesis, Université Claude Bernard - Lyon I, 2012. http://tel.archives-ouvertes.fr/tel-00865594.

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La stimulation cérébrale profonde (DBS) du gyrus cingulaire subgénual est actuellement en coursd'évaluation comme nouvelle cible thérapeutique chez les patients souffrant de dépression majeure.Afin de caractériser les mécanismes sous-jacents l'action de la DBS, et plus particulièrement, lapossible implication du système glial, les effets de la stimulation du cortex préfrontal infralimbique surplusieurs marqueurs précliniques de la réponse antidépressive ont été évalués chez le rat. Ce travailde thèse, en utilisant des approches électrophysiologiques, immunohistochimiques etcomportementales, mo

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Nogueira, Adriano Barreto. "Mapeamento de potencial nicho neurogênico no lobo temporal humano." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-13082014-152043/.

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No final do século 19, o neurônio foi descrito como a unidade funcional básica do sistema nervoso e sua formação era considerada inexistente na fase adulta, explicando a ausência de recuperação significativa em doenças neurológicas. Evidências de geração de neurônios em mamíferos adultos surgiram na década de 1960 e foram confirmadas três décadas depois. Atualmente, predomina a visão de que mamíferos adultos possuem dois nichos neurogênicos independentes: a zona subventricular (ZSV) e a zona subgranular (ZSG) do giro denteado. No entanto, a existência de nichos neurogênicos em humanos adultos

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Attias, Lior Rivka, and Lior Rivka Attias. "A genetic understanding of language development through cognitive and neurogenetic studies: an exploration of the FOXP2 gene, songbird development, human language, and autism." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626743.

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It is well known that FOXP2 has a connection to human language. In a familial case study of humans in one family with a mutated FOXP2, it was found that all members showed Developmental Verbal Dyspraxia, a cognitive language deficit. In knock out experiments in mice, it was found that FOXP2 is critical for Purkinje cell development in the brain as well as lung development. In FOXP2 knock out experiments in songbirds, it was found that songbirds could no longer learn new songs or cognitively understand song, which is used as a type of language in these animals. In knock in experiments wit

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Xia, Lin. "Analyse de profils d'expression génique dans des modèles murins d'anxiété/dépression." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00923149.

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Dans le cadre de la modélisation des pathologies anxio-dépressives, notre équipe a créé par des approches génétiques et pharmacologiques deux modèles de souris, les souris privées des récepteurs 5-HT1A et 5-HT1B de la sérotonine (5-HT1A/1B-/-) et les souris CORT ayant reçu une exposition chronique de corticostérone exogène (modèle CORT). Ces modèles présentent respectivement un phénotype hyper anxieux et anxio-dépressif. A l'aide de la technique des puces à ADN, nous avons tenté de caractériser le phénotype moléculaire des troubles comportementaux observés dans les différentes régions cérébral

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Cavallin, Mara. "Physiopathologie moléculaire et cellulaire des anomalies du développement du cortex cérébral : le syndrome d'Aicardi WDR81 mutations cause extreme microcephaly and impair mitotic progression in human fibroblasts and Drosophila neural stem cells TLE1, a key player in neurogenesis, a new candidate gene for autosomal recessive postnatal microcephaly Mutations in TBR1 gene leads to cortical malformations and intellectual disability Aicardi syndrome: Exome, genome and RNA-sequencing of a large cohort of 19 patients failed to detect the genetic cause Recurrent RTTN mutation leading to severe microcephaly, polymicrogyria and growth restriction Recurrent KIF2A mutations are responsible for classic lissencephaly Recurrent KIF5C mutation leading to frontal pachygyria without microcephaly Rare ACTG1 variants in fetal microlissencephaly De novo TUBB2B mutation causes fetal akinesia deformation sequence with microlissencephaly: An unusual presentation of tubulinopathy A novel recurrent LIS1 splice site mutation in classic lissencephaly Further refinement of COL4A1 and COL4A2 related cortical malformations Prenatal and postnatal presentations of corpus callosum agenesis with polymicrogyria caused By EGP5 mutation Delineating FOXG1 syndrome from congenital microcephaly to hyperkinetic encephalopathy Delineating FOXG1 syndrome: From congenital microcephaly to hyperkinetic encephalopathy." Thesis, Sorbonne Paris Cité, 2019. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2213&f=18201.

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Les malformations du cortex cérébral (MDC) représentent une cause importante de handicap et d'épilepsie pharmaco-résistante. Le séquençage à haut débit a permis une amélioration considérable de l'identification des bases moléculaires des MDC non syndromiques. Toutefois, certaines formes, notamment les MDC complexes, demeurent inexpliquées. Mon projet de thèse a pour objectif de progresser dans la compréhension des MDC complexes en utilisant deux modèles : les microlissencéphalies (MLIS) et le syndrome d'Aicardi (AIC), une forme syndromique particulière associant des malformations de l'oeil et

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Ahmad, Ruhel. "Neurogenesis from parthenogenetic human embryonic stem cells." Doctoral thesis, 2012. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-75935.

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Imprinted genes play important roles in brain development. As the neural developmental capabilities of human parthenogenetic embryonic stem cells (hpESCs) with only a maternal genome were not assessed in great detail, hence here the potential of hpESCs to differentiate into various neural subtypes was determined. In addition DNA methylation and expression of imprinted genes upon neural differentiation was also investigated. The results demonstrated that hpESC-derived neural stem cells (hpNSCs) showed expression of NSC markers Sox1, Nestin, Pax6, and Musashi1 (MS1), the silencing of pluripotenc

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Nelson, Aaron D. "Growth factors modulate human cortical neurogenesis in vitro." 2006. http://catalog.hathitrust.org/api/volumes/oclc/83779490.html.

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Heyworth, Nadine. "The role of adult neurogenesis and oligodendrogenesis in age-related cognitive decline in the non-human primate." Thesis, 2016. https://hdl.handle.net/2144/16729.

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Cognitive aging is a biological process characterized by physical changes in the brain and subsequent alterations in cognitive function. While neurodegenerative diseases result in extensive neuronal death and anatomical abnormalities, normal aging has subtle changes resulting in a range of cognitive abilities. Early studies of cognitive aging focused on changes in the neuronal population, but evidence has demonstrated that forebrain neurons are largely preserved with age. Furthermore, the proliferation of new neurons in the adult brain has generated great speculation regarding the role and con

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Palitz, Lauren. "Neurogenesis in the subventricular zone and hippocampus following cell therapy in a non-human primate model of cortical damage." Thesis, 2016. https://hdl.handle.net/2144/19483.

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Approximately 795,000 Americans experience a new or recurrent stroke each year (American Heart Association 2016; Mozaffarian et al. 2016). However, the only experimental therapeutic to have gained FDA approval for treatment of stroke in humans is the thrombolytic agent tPA that can dissolve clots and restore blood flow, if given within a narrow therapeutic window of a few hours following stroke onset (AHA 2016, Li et al. 2016). Nevertheless, in many cases with or without tPA there is significant residual impairment, and there are currently no FDA approved therapeutic agents that facilitate fun

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Großert, Alessandra. "Elucidation of the molecular mechanism of action of psychoactive substances as novel antidepressants." Doctoral thesis, 2020. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-202003312713.

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According to the World Health Organization (WHO) depression is the leading cause of disability worldwide with more than 300 million patients affected. Current antidepressants have a delayed onset of action and moreover, only two-thirds of patients suffering from depressive disorder respond to antidepressant drug treatment. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine offers promising perspectives for the treatment of major depressive disorder. Although ketamine demonstrates rapid and long-lasting effects, even in treatment-resistant patients, to date, the underlying mode of act

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Chen, Wan-shih, and 陳宛詩. "Human umbilical cord blood-derived CD34+ cells attenuate inflammation but stimulate both angiogenesis and neurogenesis after traumatic brain injury in rats." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/955k2r.

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碩士<br>嘉南藥理科技大學<br>藥物科技研究所<br>100<br>Umbilical cord blood contained <0.2% CD34+ cells have been shown to be beneficial in reducing neurological deficits in animals after fluid percussion injury（FPI）. This study aimed to generate cord blood-derived CD34+ cells（>95%）and to investigate the mechanisms underlying their beneficial effects in treating FPI in rats. Rats were divided into three groups:（1）sham operation; （2）FPI+CD34- cells（5×105 cord blood lymphocytes and monocytes that containing <0.2% CD34+ cells）; and （3） FPI+CD34+ cells（5×105 cord blood lymphocytes and monocytes that contained 95% CD

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Stringer, Megan Elizabeth. "Effect of Epigallocatechin-3-gallate on a pattern separation task and hippocampal neurogenesis in a mouse model of Down syndrome." Thesis, 2015. http://hdl.handle.net/1805/10037.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Down syndrome (DS) is caused by three copies of human chromosome 21 (Hsa21) and results in an array of phenotypes including intellectual disability. Ts65Dn mice, the most extensively studied DS model, have three copies of ~50% of the genes on Hsa21 and display many phenotypes associated with DS, including cognitive deficits. DYRK1A is found in three copies in humans with Trisomy 21 and in Ts65Dn mice, and is involved in a number of critical pathways including CNS development and osteoclastogenesis. Epigallocatechin-3-gallate (EGCG)

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Miljus, Natasa. "Erythropoietin-mediated neuroprotection in insects." Doctoral thesis, 2016. http://hdl.handle.net/11858/00-1735-0000-0028-881F-A.

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Kerr, Fiona. "Creating and leading adaptive organisations: the nature and practice of emergent logic." Thesis, 2014. http://hdl.handle.net/2440/91144.

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This study examines how leaders enable their organisations to adapt and succeed in complex environments. Through the joint lenses of complexity theory and the cognition and social neuroscience of leadership it focuses on how leadership directly influences the creation and ongoing function of an adaptive organisation. The study includes the comparison of four leaders through embedded case studies as an abductive approach to initial theory building, and the follow up of two of them as a comparative method of analysis, and it generates a substantive theory of leadership cognition called emergent

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Bayer, Ronny. "Veränderungen der adulten Neurogenese im Hippocampus von Drogenabhängigen: Immunhistochemische Untersuchungen mit ausgewählten Neurogenesemarkern." Doctoral thesis, 2014. https://ul.qucosa.de/id/qucosa%3A13236.

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Die Neubildung von Neuronen persistiert lebenslang in der Subgranularzellschicht des Hippocampus und der Subventrikularzone des Großhirns und wird als adulte Neuroge-nese bezeichnet. Es wird vermutet, dass diese beim erwachsenen Menschen einen rele-vanten Einfluss auf degenerative Veränderungen, verschiedene neurologische Krank-heitsbilder und auf die (Dys-)Funktion des Gedächtnisses hat. Im Tiermodell wurde eine Verringerung der Neurogenese nach chronischer Morphingabe nachgewiesen. Vorarbeiten zeigten einen Zusammenhang zwischen chronischem Heroinmissbrauch und reaktiver Astrogliose, Mikrogl

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Girard, Simon L. "Étude sur le rôle des déséquilibres génomiques dans le Syndrome d’Impatiences Musculaires de l’Éveil." Thèse, 2010. http://hdl.handle.net/1866/4115.

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Le Syndrome d’Impatiences Musculaires de l’Éveil (SIME) est une maladie neurologique caractérisée par un besoin urgent de bouger les jambes. C’est également l’une des causes les plus fréquentes d’insomnie. C’est une maladie très répandue, avec une prévalence de presque 15 % dans la population générale. Les maladies multifactorielles comme le SIME sont souvent le résultat de l’évolution d’une composante génétique et d’une composante environnementale. Dans le cadre du SIME, les études d’association génomique ont permis l’identification de 4 variants à effet modéré ou faible. Cependant, ces quatr

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