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Rozprawy doktorskie na temat „Humoral immunity”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Nohr, Carl William. "Humoral immunity in surgical patients." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75969.

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Humoral immune function was studied in surgical patients. The antibody response to vaccination with a protein antigen, tetanus toxoid (TT), was reduced among all patients, especially those with reduced delayed type hypersensitivity (DTH) and increased degree of physiological derangement. The antibody response to a polysaccharide antigen, pneumococcal polysaccharide (PPS), was normal. In trauma patients, the antibody response to TT was normal. The in vitro production of specific and total immunoglobulin (Ig) by blood mononuclear cells was studied. Patients that failed to produce a serum antibod

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2

Cassis, Linda 1977. "Role of progranulin in humoral immunity." Doctoral thesis, Universitat Pompeu Fabra, 2015. http://hdl.handle.net/10803/398398.

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Human spleen is continually exposed to blood-borne antigens derived from autologous apoptotic cells and commensal bacteria. This chronic stimulation of the marginal zone (MZ) results in the generation of a steady-state antibody response that occurs under non-inflammatory conditions. Immunoregulatory signals, still poorly understood, are required to avoid continuous inflammation. Our group identified a population of splenic neutrophils called B cell-helper neutrophils (NBH cells) that contribute to the induction of steady-state antibody responses in the MZ1. NBH cells express B cell-activat

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3

Rydyznski, Carolyn E. "Natural Killer Cell Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535377157934852.

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Berkeley, Robert Anthony. "Immune cell carriers and humoral immunity in oncolytic virotherapy." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20532/.

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Oncolytic viruses (OV) represent an emerging modality in cancer therapy. Antiviral immunity is currently viewed as a barrier to systemic OV efficacy. Approaches have been taken to promote OV activity by attenuating virus-neutralising antibodies (NAb). However, the presence of NAb does not prevent intravenously administered OV, such as reovirus, reaching tumours in patients. Recent evidence suggests that NAb may in fact support virotherapy in mice by facilitating reovirus carriage upon circulating immune cells, principally monocytes. In this thesis, the applicability of these observations to th

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Willems, Kristen N. "Regulation of Humoral Immunity by Pim Kinases: A Dissertation." eScholarship@UMMS, 2011. https://escholarship.umassmed.edu/gsbs_diss/567.

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Pim (Provirus Integration site for Moloney murine leukemia virus) kinases are a family of three serine/threonine kinases involved in cell cycle, survival and metabolism. These kinases were first identified in malignant cells and are most often associated with their role in cancer. Their role in immunity and lymphocytes is less well known. To date, it has been shown that Pim 1 and/or Pim 2 are important for T lymphocyte survival and activation when the Akt signaling pathway is inhibited by rapamycin. In addition, our laboratory has shown that Pim 2 is critical for BLyS-mediated naive B lymphocy

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6

Bruns, Nicholas Joseph. "Humoral and cell-mediated immunity in vitamin A-deficient lambs." Diss., Virginia Polytechnic Institute and State University, 1988. http://hdl.handle.net/10919/53919.

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Antigen-specific and polyclonal serum immunoglobulin G (IgG) concentrations were measured in control (Con), vitamin A-deficient (A-def), and vitamin A-repleted (A-rep) lambs. In Trial, I ewe lambs were injected with primary and secondary antigenic challenges of ovalbumin (1mg) and lysozyme (.1mg). The A-def lambs were then repleted with vitamin A and all lambs were injected with primary and secondary antigenic challenges of human gamma globulin (HGG) (.1mg). In Trial II Con and A-def wether lambs were given primary and secondary antigenic challenges of ovalbumin (20μg). Half of the A-def lambs

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7

Sallam, Jamal A. "Intestinal humoral immunity in man : IgA and anti-salmonella antibodies." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/20766.

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Studies of gut immunity must be carried out on intestinal fluid and jejunal biopsies. Recent work from Edinburgh has shown that the use of Whole Gut Lavage (WGL) technique is a non-invasive, direct and reliable method of obtaining intestinal fluids. My thesis describes the use of WGL technique in a variety of studies on gastro-intestinal mucosal immunity. The effect of the newly licensed oral live typhoid vaccine Ty21a on gut immunity was investigated in a group of 22 healthy British volunteers. Later on, the intestinal immune responses to naturally acquired <I>Salmonella</I> infection were in

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8

Casas, Rosaura. "Transfer of humoral immunity from the mother to her off-spring /." Linköping : Univ, 2001. http://www.bibl.liu.se/liupubl/disp/disp2001/med692s.pdf.

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Lucin, Kurt M. "Mechanisms of impaired humoral immunity after high thoracic spinal cord injury." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186411177.

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Titanji, Kehmia. "Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-728-6/.

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Ng, D. H. L. "Loss and recovery of humoral immunity to influenza virus following malaria infection." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1349451/.

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The mechanisms of maintenance of humoral immunity to infectious pathogens, particularly the contributions of memory B cells and long-lived plasma cells in maintaining specific serum antibody titres, are not well understood. Furthermore, it is not clear whether sequential heterologous humoral immune responses and disease pathology can result in the dysregulation and loss of previously acquired antibody-mediated immune responses to unrelated antigens. Here, depletion of memory B cells using anti-hCD20 monoclonal antibodies in hCD20 transgenic mice was used to dissect the role of memory B cells a

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Чорненька, Жанетта Анатоліївна. "CHARACTERISTIC OF INDICATORS OF CELLULAR AND HUMORAL IMMUNITY IN PATIENTS WITH DEMODECOSIS." Thesis, Материалы 72-й научно-практической конференции студентов-медиков и молодых ученых с международным участием «Актуальные проблемы современной медицины». Самарканд 11-12 мая 2018 г. С.382, 2018. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/14251.

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Lownik, Joseph C. "The Role of ADAM10 and ADAM17 in Humoral and Type 2 Immunity." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5680.

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The proper regulation of inducible costimulator (ICOS) and its ligand (ICOSL) have been shown to be essential for maintaining immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant antibody production resembling lupus. How ICOSL is regulated in response to ICOS interaction is still unclear. We demonstrate that ADAM10 is the primary physiological sheddase of ICOSL in both mouse and human. Using an in vivo system in which ADAM10 is deleted only on B cells (ADAM10B-/-), elevated levels of ICOSL were seen. This increase is a

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14

Blevins, Sarah. "Characterizing Compensatory Effects of Silymarin on Gossypol Toxicosis in Lines of Chickens Divergently Selected for Humoral Immune Response." Thesis, Virginia Tech, 2009. http://hdl.handle.net/10919/34609.

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Feed costs are approximately 70% of total production cost for poultry producers. Poultry diets in the United States generally consist of 2 grains: corn and soybean meal. In recent years, the cost of these grains has dramatically increased. Due to these price increases, producers seek alternative feeds that provide adequate nutrition, and are also more affordable than â traditionalâ grains. Cottonseed meal is one alternative that is both affordable and an excellent source of crude protein. However, cottonseed meal contains gossypol, a pigment toxic to chickens. This study had two main object

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15

White, Sarah Elise, and Sarah Elise White. "Can current methods of immune rejuvenation improve humoral immunity against a viral infection?" Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626801.

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The process of aging impacts immune defense against infection. This is attributed to immunosenescence, which is defined as a gradual decline in the function of the immune system. This decline is widespread, affecting both cell-mediated and humoral immunity, which both play an integral role in pathogen recognition and elimination. Lymphoid organs are known to undergo structural and functional changes with age and understanding these changes and how they can be prevented or reversed is critical if we are to improve immunity in older adults. We studied two immune rejuvenation methods: the a

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16

Wong, Garret Drew. "Human humoral immunity to respiratory syncytial virus, correlates of disease severity and protection." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/MQ32975.pdf.

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Majid, Amir Abdul Fattah Abdul. "Humoral immunity to melanoma antigens in patients with benign & malignant pigmented dermatoses." Thesis, University of London, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.362838.

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SILVA, Fabiana Leticia da. "Efeitos da amamentação em camundongos esquistossomóticos na imunidade anti-ovalbumina de descendentes adultos deficientes na produção das citocinas IL-12/IL-23." Universidade Federal de Pernambuco, 2014. https://repositorio.ufpe.br/handle/123456789/17158.

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Submitted by Fabio Sobreira Campos da Costa (fabio.sobreira@ufpe.br) on 2016-06-28T14:37:59Z No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE_FABIANA_LETICIA_DIGITAL.pdf: 2539644 bytes, checksum: ffb2ea48912cab654c0a8e8bdc397ac2 (MD5)<br>Made available in DSpace on 2016-06-28T14:37:59Z (GMT). No. of bitstreams: 2 license_rdf: 1232 bytes, checksum: 66e71c371cc565284e70f40736c94386 (MD5) TESE_FABIANA_LETICIA_DIGITAL.pdf: 2539644 bytes, checksum: ffb2ea48912cab654c0a8e8bdc397ac2 (MD5) Previous issue date: 2014-08-27<br>FACEPE<br>O contato prévi

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Clyne, Erin Michele. "DIFFERENTIAL GENE EXPRESSION IN PERIPLANETA americana IN RESPONSE TO IMMUNIZATION WITH BEE PHOSPHOLIPASE A2." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin997793741.

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Clyne, Erin M. "DIFFERENTIAL GENE EXPRESSION IN PERIPLANETA AMERICANA IN RESPONSE TO IMMUNIZATION WITH BEE PHOSPHOLIPASE A2." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin998324478.

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Vickery, Karen. "The humoral and cellular responses to duck hepatitis B virus." Thesis, The University of Sydney, 1994. https://hdl.handle.net/2123/26913.

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Acute and chronic HBV infection and the resulting liver damage including hepatocellular carcinoma (HCC) are major health problems placing large demands on health resources. In high prevalence areas transmission occurs principally perinatally or in early childhood resulting in a high incidence of chronic life-long carriers. Progress in the study of HBV infection, replication and pathogenesis has depended to a large extent on the development of animal models such as the duck/DHBV model. Although less related to HBV than the mammalian models DHBV was used to demonstrate the unique replication str

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22

Moran, Michael. "Moving in for the Kill: Natural Killer Cell Localization in Regulation of Humoral Immunity." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460446618.

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Bin, Sofia <1990&gt. "Erythropoietin reduces pathogenic humoral immunity by inhibiting T Follicular Helper cell differentiation and function." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9694/1/TesiPhD_SofiaBin_Final.pdf.

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A large fraction of organ transplant recipients develop anti-donor antibodies (DSA), with accelerated graft loss and increased mortality. We tested the hypothesis that erythropoietin (EPO) reduces DSA formation by inhibiting T follicular helper (TFH) cells. We measured DSA levels, splenic TFH, TFR cells, germinal center (GC), and class switched B cells, in murine models of allogeneic sensitization, allogeneic transplantation and in parent-to-F1 models of graft versus host disease (GVHD). We quantified the same cell subsets and specific antibodies, upon EPO or vehicle treatment, in wild type

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24

Cox, Rebecca Jane. "The humoral immune response in the peripheral blood and upper respiratory tract after influenza vaccination." Thesis, Queen Mary, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369509.

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Flanagan, Brian. "The immunogenicity of a recombinant adenovirus expressing the SIV gag gene in mice." Thesis, University of Warwick, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265616.

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Barrault, Denise Viviane. "The putative role of humoral antibacterial peptides on Onchocerca spp. transmission by simuliids (Diptera: Simuliidae)." Thesis, Keele University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311729.

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Cooley, Lauren Folgosa. "The role of ADAM10, ADAM17, and Spag6 in humoral immunity and secondary lymphoid tissue architecture." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3808.

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ADAM10, ADAM17, and SPAG6 contribute significantly to humoral immunity and secondary lymphoid tissue architecture. ADAM10 and ADAM17 are two closely related zinc-metalloproteinases. Through cleavage of their ligands CD23 and TNF, respectively, they greatly influence IgE production and secondary lymphoid tissue architecture maintenance. Th1 prone WT strains initially exhibit increased ADAM17 and TNF yet reduced ADAM10 relative to Th2 prone WT strains. In the absence of B cell ADAM10, a compensatory increase in ADAM17 and TNF cleavage is noted only in Th1 prone C57Bl/6, not Th2 prone Balb/c. B c

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Santos, Liliane Almeida Carneiro. "Estudo prospectivo sobre a dinâmica da evolução clínica e imunológica da infecção canina por Leishmania (Leishmania) infantum chagasi em área endêmica de leishmaniose visceral no estado do Pará." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10133/tde-27102016-142051/.

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Leishmaniose visceral canina (LVC) é um dos problemas de saúde pública mais importantes da América Latina, pois geralmente precede a doença humana, a leishmaniose visceral americana (LVA), causada pela Leishmania (L.) infantum chagasi. No presente estudo prospectivo analisou-se durante período de dois anos a prevalência, incidência e dinâmica da evolução clínico-imunológica da infecção canina pela L. (L.) i. chagasi em uma coorte de 316 cães mestiços que vivem em área endêmica de LVA no município de Barcarena, Pará, Amazônia Brasil, pelo uso combinado do teste de imunofluorescência indireta (R

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Effertz, Bernard Stephen. "The humoral immune response to streptococcal cell wall-induced arthritis in the rat." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184877.

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I investigated the humoral immune response to streptococcal cell walls (SCW) in arthritis susceptible Lewis and resistant Fisher rats. All rats were given a single intraperitoneal injection of either SCW or saline (controls). Rats were sacrificed, three rats per time point, over an eleven week period and serum was collected for ELISA. SCW injected Lewis rats produced anti-SCW antibody, whereas control rats did not. Anti-SCW antibody was significantly elevated over controls between days 14-28 (post injection). Both saline and SCW injected Fisher rats produced anti-SCW antibody, but with differe

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Tsukuda, Lilia Rios. "Imunidade humoral na toxoplasmose ocular." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-29012008-155252/.

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T. gondii é um protozoário amplamente disseminado pelo mundo que pode causar doença em animais e humanos. A evolução e a gravidade da doença dependem de características genéticas do parasita e do hospedeiro. A prevalência varia geograficamente, em Erechim, RS, 88% da população é soropositiva e 18% destes apresentam toxoplasmose ocular (TO). A resposta imune humoral contra T. gondii é persistente em todas as fases da infecção. O objetivo deste retrospectivo estudo foi correlacionar a imunidade humoral e a resposta contra peptídeos cepa-específicos com a gravidade da TO em pacientes de Erechim.

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Skott, Pia. "HIV induced humoral immune response with specific relevance to IgA /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-240-x/.

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Suppiah, Aravind. "Humoral immunity in colorectal cancer : evaluation of the anti-p53 and anti-hTERT auto-antibody responses." Thesis, University of Hull, 2010. http://hydra.hull.ac.uk/resources/hull:5741.

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Carcinogenesis is a multi-factorial and multi-aetiological process involving suppressions, alterations and re-activation of key biomolecular markers. Some of these changes are recognised by the humoral system and are known as Tumour Associated Antigens (TAA) against which the humoral system is able to mount an auto-antibody response. Cancer cells are subject to two key mortality barriers (M1 & M2) as described in the "2-hit" hypothesis which are overcome by p53 dysfunction (M1) and hTERT re-expression (M2). These two molecular events generate TAA which are recognised by the humoral immune syst

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Thyagarajan, Radha. "Anomalies in humoral immunity in the NOD mouse : contribution to the progression of type 1 diabetes." Doctoral thesis, Umeå universitet, Immunologi/immunkemi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-125001.

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The non-obese diabetic (NOD) mouse is widely used model Type 1 diabetes (T1D), a chronic inflammatory disease characterized by destruction of the insulin producing β cells in the islets of Langerhans by immune cells. The classical symptoms include increased glucose levels in urine and blood, frequent urination and enhanced thirst. The disease has a strong genetic component and is also influenced by the environment. NOD mice develop T1D spontaneously. The disease occurs in two phases; insulitis - the infiltration of immune cells in the islets of Langerhans and overt diabetes caused by the destr

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Moreira, Iramirton Figueirêdo. "Imunidade humoral e celular de crianças com desnutrição crônica semi-internas no centro de recuperação e educação nutricional, CRE Maceió/AL - 2008." Universidade Federal de Alagoas, 2009. http://repositorio.ufal.br/handle/riufal/643.

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The World Health Organization defines protein-energy malnutrition as a range of pathological conditions that appear by a deficient supply, transport or use of nutrients by the body s cells causing an essential amino acid deficiency in DNA and RNA synthesis, which can lead to a substantial immune system impairment. The focus of this research was to evaluate humoral and cellular immunity in children suffering from moderate to severe chronic malnutrition. The cross-sectional study was conducted with children 24-59 months old and 29 days, semi-interned at the Nutritional and Education Recovery Cen

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SILVA, Bárbara Brooklyn Timóteo Nascimento. "Aspectos imunológicos do caramujo Pomacea lineata (Spix, 1827) sob condições de estivação induzida." Universidade Federal Rural de Pernambuco, 2014. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5039.

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Submitted by (edna.saturno@ufrpe.br) on 2016-07-19T13:52:24Z No. of bitstreams: 1 Barbara Brooklyn Timoteo Nascimento Silva.pdf: 534821 bytes, checksum: 10562bfdf804ec2c27773d76d75cefab (MD5)<br>Made available in DSpace on 2016-07-19T13:52:24Z (GMT). No. of bitstreams: 1 Barbara Brooklyn Timoteo Nascimento Silva.pdf: 534821 bytes, checksum: 10562bfdf804ec2c27773d76d75cefab (MD5) Previous issue date: 2014-02-21<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES<br>Pomacea lineata (Spix, 1827) is a pulmonate gastropod that has a large dependence on humidity, Ampullari

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Tran, Mai Hue. "Investigations of humoral and cellular immune responses directed against MUCI epithelial mucin in ovarian and breast carcinoma /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17997.pdf.

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Zorzeto, Tatiane Queiroz. "Resposta humoral e celular de lactentes vacinados com pertussis celular total ou modificada pela extração de lipopolissacarideo." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/311081.

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Orientador: Maria Marluce dos Santos Vilela<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T01:20:12Z (GMT). No. of bitstreams: 1 Zorzeto_TatianeQueiroz_M.pdf: 1695884 bytes, checksum: 267f0534bc256440762ad9d78bc6402d (MD5) Previous issue date: 2008<br>Resumo: A associação temporal de eventos adversos de variada gravidade à imunização com pertussis celular total (DTP) tem estimulado o desenvolvimento de vacinas antipertussis menos reatogênicas. Este ensaio clínico fase I visou à avaliação da imunogenicidad

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Feola, David James. "EFFECT OF COMBINATION EXPOSURE TO ZIDOVUDINE AND SULFAMETHOXAZOLE-TRIMETHOPRIM ON IMMUNE RESPONSE IN MICE AND HUMANS." UKnowledge, 2005. http://uknowledge.uky.edu/gradschool_diss/411.

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The drug-drug interaction involving zidovudine and sulfamethoxazole-trimethoprim was investigated using an in vitro culture system, an in vivo mouse model, and a clinical trial in HIV-infected patients. We hypothesized that combination exposure causes immune cell populations in the bone marrow to undergo apoptotic cell death, and that the toxicity would affect the host response to an infectious stimulus. Mice were dosed with zidovudine, sulfamethoxazole-trimethoprim, the combination of both drugs, or vehicle only control via oral gavage. Focusing on B-lineage cells in the bone marrow, we deter

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Hein, Héber Eduardo. "Influência da imunidade de matrizes suínas na resposta à vacinação de leitões contra Mycoplasma hyopneumoniae." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/127074.

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A suinocultura está amplamente difundida no Brasil, o quarto maior produtor mundial de carne suína. Seu efetivo está concentrado em maior parte na região Sul, com 48,8% dos suínos. Porém, a intensificação e o confinamento das criações expõem os animais a agentes patogênicos, como o Mycoplasma hyopneumoniae (Mhyo), causador da Pneumonia Enzoótica Suína (PES). A doença é caracterizada pela ocorrência de tosse seca não produtiva e lesões pulmonares de consolidação, denominadas hepatização. A vacinação de leitões é uma importante ferramenta empregada no controle da PES. Contudo, é relatado que a i

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Горбась, Вікторія Анатоліївна, Виктория Анатольевна Горбась, Viktoriia Anatoliivna Horbas, Олександр Іванович Сміян, Александр Иванович Смиян та Oleksandr Ivanovych Smiian. "Стан гуморального імунітету у дітей шкільного віку з негоспітальними пневмоніями". Thesis, Вид-во СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/5647.

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Метою роботи явилось вивчення особливостей гуморального імунітету у дітей з негоспітальними пневмоніями (НП) в залежності від періоду захворювання, тяжкості перебігу запального процесу При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/5647

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Купина, Максим Вікторович, Максим Викторович Купина, Maksym Viktorovych Kupyna та ін. "Стан гуморального імунітету в залежності від стадії захворювання у хворих різних вікових груп з деформуючим спондилоартрозом поперекового відділу хребта". Thesis, Вид-во СумДУ, 2007. http://essuir.sumdu.edu.ua/handle/123456789/5124.

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Купина, О. В., Максим Вікторович Купина, Максим Викторович Купина та Maksym Viktorovych Kupyna. "Ефективність лікування пневмоній залежно від стану гуморального імунітету". Thesis, Видавництво СумДУ, 2009. http://essuir.sumdu.edu.ua/handle/123456789/4550.

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Kummu, O. (Outi). "Humoral immune response to carbamyl-epitopes in atherosclerosis." Doctoral thesis, Oulun yliopisto, 2014. http://urn.fi/urn:isbn:9789526205670.

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Abstract Carbamylation of proteins in vivo occurs by cyanate, non-enzymatically when urea is dissociated, and by myeloperoxidase-catalyzed oxidation from thiocyanate. Carbamylation of low-density lipoprotein is suggested to enhance atherogenesis in patients with with chronic kidney disease and uremia. This thesis study assessed the questions of whether healthy humans or uremic patients under enhanced carbamylation have antibodies recognizing carbamyl-epitopes in plasma, and what is their role in vivo. Also, humoral immune response to carbamyl-LDL immunization and its impact on atherogenesis in

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Antonio, Aline Lavezo. "Carcinogênese induzida por DMBA em camundongo selecionados para a alta ou baixa produção de anticorpos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-24092014-180622/.

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A tumorigênese cutânea é determinada pela combinação de diversos fatores genéticos e ambientais, que envolvem múltiplos eventos onde as células epiteliais podem progredir e se desenvolverem. Todo esse processo é associado com alterações da imunidade celular e humoral. Muitos fatores físicos e químicos podem predispor ao câncer de pele, como o carcinógeno DMBA, com ação iniciadora e promotora. Camundongos geneticamente selecionados para a alta (High) ou baixa (Low) produção de anticorpos constituem uma excelente ferramenta para o estudo da influência da imunidade humoral no desenvolvimento de t

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Vila, Nova Ana Beatriz de Matos Machado. "Avaliação da resposta imunitária humoral induzida pela vacinação para esgana e parvovirose caninas." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2017. http://hdl.handle.net/10400.5/13950.

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Dissertação de Mestrado Integrado em Medicina Veterinária<br>O vírus da esgana (CDV) e o parvovírus (CPV) são dois vírus responsáveis por elevadas taxas de mortalidade nas populações caninas, que infetam cães não vacinados ou com protocolos vacinais incompletos. As vacinas têm desempenhado um papel fundamental na prevenção destas doenças no entanto, a vacinação não é um procedimento inócuo e deve ser realizado apenas com a frequência necessária para manter os cães imunizados. Por outro lado, são vários os fatores que podem originar falhas na imunização, sendo a neutralização do antigénio vaci

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Blanc, Pascal. "Expression et fonction du récepteur antigénique B membranaire sur les plasmocytes médullaires producteurs d'IgM." Thesis, Lyon 1, 2015. http://www.theses.fr/2015LYO10026/document.

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Le plasmocyte (PC), stade terminal de la différenciation du lymphocyte B induite par l'antigène, est la cellule effectrice de l'immunité humorale responsable de la production des anticorps. La population plasmocytaire se divise en deux grands sous-types différant par leur durée de vie et par leur localisation anatomique. On distingue ainsi les PC à durée de vie courte ou PC effecteurs (dans les tissus lymphoïdes secondaires) et les PC à longue durée de vi (LLPC ou PC à mémoire) localisés principalement dans la moelle osseuse. Ces derniers contribuent à la mémoire humorale en continuant à sécré

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Neville, Judith Anne. "The extent of genotype specific humoral immunity produced on infection with hepatitis C virus : relevance for serological screening and diagnosis." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/27115.

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Sequence variation in the antigenic determinants in core, NS3, NS4A/B and NS5A/B proteins, may produce genotype-specific antibodies which do not cross-react with the antigens used in current screening assays for detection of antibody to HCV. The extent of type-specific and type-common components of the humoral immune response were investigated by measuring the antibody levels in samples of each genotype with type-homologous and type-heterologous antigens. Reactivity directed against the individual genotype 1 antigens used in a commercially available anti-HCV screening assay (VK48; Murex Biotec

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Rahman, Bhuiyan Taufiqur. "Humoral and cellular immune responses to Helicobacter pylori in Bangladeshi children and adults that may be related to protection /." Götborg : Department of Microbiology and Immunology, Institute of Biomedicine at Sahlgrenska Academy, University of Gotheburg, 2010. http://hdl.handle.net/2077/21536.

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Rogers, Kenneth Alton. "Immunoglobulins and Immunoglobulin Fc Receptors in Nonhuman Primates Commonly Used in Biomedical Research." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/6.

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Antibodies neutralize and eliminate pathogens, malignancies, and toxins by acting either alone or in association with Fc receptors which, once engaged, activate the elimination mechanisms of phagocytic cells. Based on structural differences, antibodies are divided into functionally distinct classes (IgM, IgD, IgG, IgE and IgA). Structure-function relationships within these classes are not well characterized. In addition, animal models for the assessment of potential therapeutic strategies for the modulation of the interaction between antibodies and Fc receptors are not established. Nonhuman pr

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Siba, Valentine. "EFFECT OF BED NETS ON ACQUIRED HUMORAL IMMUNITY TO PLASMODIUM FALCIPARUM ANTIGENS IN CHILDREN FROM MUGIL, MADANG PROVINCE, PAPUA NEW GUINEA." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1485675594752553.

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