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Artykuły w czasopismach na temat „Hybrid immunity”

Autor: Grafiati

Data publikacji: 1 lutego 2025

Data aktualizacji: 31 lipca 2025

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1

Crotty, Shane. "Hybrid immunity." Science 372, no. 6549 (2021): 1392–93. http://dx.doi.org/10.1126/science.abj2258.

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Tang, Jinyi, Arka Chaudhuri, Panke Qu, et al. "Respiratory mucosal immunity against SARS-CoV-2 after vaccination and infection." Journal of Immunology 212, no. 1_Supplement (2024): 1559_5071. http://dx.doi.org/10.4049/jimmunol.212.supp.1559.5071.

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Abstract The current COVID-19 mRNA vaccine is effective in systemic immune memory but lacks in generating mucosal anti-SARS-CoV-2 immunity. While prior SARS-CoV-2 infection establishes respiratory immunity, its strain-specific nature and limited duration pose challenges for sustained protection. Recent research has shown that hybrid immunity, a combination of vaccination and infection, results in a more robust, durable, and broadly reactive immune response in circulation compared to vaccination or infection alone. However, the characteristics and protective mechanisms of hybrid immunity in the

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Shi, Meiqing, Liping Su, Sigou Hao, Xulin Guo, and Jim Xiang. "Fusion Hybrid of Dendritic Cells and Engineered Tumor Cells Expressing Interleukin-12 Induces Type 1 Immune Responses against Tumor." Tumori Journal 91, no. 6 (2005): 531–38. http://dx.doi.org/10.1177/030089160509100614.

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Aims and Background Dendritic cell (DC)-tumor fusion hybrid vaccinees that facilitate antigen presentation represent a novel powerful strategy in cancer immunotherapy. Preclinical studies have demonstrated that IL-12 promotes specific antitumor immunity mediated by T cells in several types of tumors. In the present study, we investigated the antitumor immunity derived from vaccination of fusion hybrids between DCs and engineered J558/IL-12 myeloma cells secreting Th1 cytokine IL-12. Methods The expression vector pcDNA-IL-12 was generated and transfected into J558 myeloma cells and then bone ma

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Sizyakina, L. P., V. Ya Zakurskaya, and I. I. Andreeva. "Capacities of hybrid immunity: objective realities." Immunologiya 45, no. 3 (2024): 300–311. http://dx.doi.org/10.33029/1816-2134-2024-45-3-300-311.

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Kanokudom, Sitthichai, Jira Chansaenroj, Suvichada Assawakosri, et al. "Real-World Study: Hybrid Immunity against SARS-CoV-2 Influences the Antibody Levels and Persistency Lasting More than One Year." Vaccines 11, no. 11 (2023): 1693. http://dx.doi.org/10.3390/vaccines11111693.

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This study investigated the impact of hybrid immunity on antibody responses in the participants who received two to seven doses of the COVID-19 vaccine. The study was conducted between April and June 2023. Out of 771 serum samples analyzed, 71.7% exhibited hybrid immunity (positive for total anti-N Ig), while 28.3% showed vaccine-induced immunity (negative for total anti-N Ig). Participants were categorized based on the number of vaccine doses: 2, 3, 4, and ≥5. The findings highlight a trend where a higher number of vaccine doses received was associated with a lower infection rate. There was n

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Bakunov, Aleksey Lvovich, Sergey Leonidovich Rubtsov, Artyom Alekseevich Vyazovoy, Nadezhda Vasilievna Gulaeva, and Aleksey Viktorovich Milekhin. "Evaluation of a promising potato hybrid material in terms of plasticity, genotype stability and resistance to pathogens." Agrarian Scientific Journal, no. 1 (February 7, 2025): 4–10. https://doi.org/10.28983/asj.y2025i1pp4-10.

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The prospective hybrid material was evaluated according to the parameters of adaptability and stability of the genotype, as well as the presence of markers of resistance genes to potato Y-virus, potato X-virus, golden potato nematode, pale nematode and potato cancer in the agroclimatic conditions of the Samara region. The research was carried out in the fields of the Samara Scientific Research Agriculture Institute in contrasting cultivation conditions in 2021-2023. Hybrids with maximum yield and characterized by low variability of this trait have been identified. Promising hybrids combining h

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Tatarnikova, V. V., V. I. Dubrovina, N. O. Kiseleva, et al. "Effect of Immunity to SARS-CoV-2 Virus on Blood Cellular Composition." Epidemiology and Vaccinal Prevention 23, no. 2 (2024): 50–60. http://dx.doi.org/10.31631/2073-3046-2024-23-2-50-60.

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Relevance. The new coronavirus infection (COVID-19) is still a public health problem and a threat to socio-economic well-being. Most studies have focused predominantly on humoral immunity, and there are no data on the cellular composition of blood in dynamics. Aim. To study the dynamics of changes in blood cellular composition depending on the type of immunity formed (natural, hybrid, breakthrough, postvaccinal) to SARS-CoV-2 virus. Materials and Methods. A total of 130 volunteers participated in the study. Immunophenotyping of peripheral blood leukocytes using flow cytometry was performed. Th

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Kodera, Sachiko, Akito Takada, Essam A. Rashed, and Akimasa Hirata. "Projection of COVID-19 Positive Cases Considering Hybrid Immunity: Case Study in Tokyo." Vaccines 11, no. 3 (2023): 633. http://dx.doi.org/10.3390/vaccines11030633.

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Since the emergence of COVID-19, the forecasting of new daily positive cases and deaths has been one of the essential elements in policy setting and medical resource management worldwide. An essential factor in forecasting is the modeling of susceptible populations and vaccination effectiveness (VE) at the population level. Owing to the widespread viral transmission and wide vaccination campaign coverage, it becomes challenging to model the VE in an efficient and realistic manner, while also including hybrid immunity which is acquired through full vaccination combined with infection. Here, the

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Livieratos, Achilleas, Lars Erik Schiro, Charalambos Gogos, and Karolina Akinosoglou. "Durability of Adaptive Immunity in Immunocompetent and Immunocompromised Patients Across Different Respiratory Viruses: RSV, Influenza, and SARS-CoV-2." Vaccines 12, no. 12 (2024): 1444. https://doi.org/10.3390/vaccines12121444.

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Background/Objectives. Research on respiratory virus immunity duration post-vaccination reveals variable outcomes. This study performed a literature review to assess the efficacy and longevity of immune protection post-vaccination against SARS-CoV-2, influenza, and respiratory syncytial virus (RSV), with a focus on immunocompromised populations. Specific objectives included examining humoral and cellular immune responses and exploring the impact of booster doses and hybrid immunity on extending protection. Methods. A literature review was conducted focusing on studies published from January 20

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Diani, Sara, Erika Leonardi, Attilio Cavezzi, et al. "SARS-CoV-2—The Role of Natural Immunity: A Narrative Review." Journal of Clinical Medicine 11, no. 21 (2022): 6272. http://dx.doi.org/10.3390/jcm11216272.

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Background: Both natural immunity and vaccine-induced immunity to COVID-19 may be useful to reduce the mortality/morbidity of this disease, but still a lot of controversy exists. Aims: This narrative review analyzes the literature regarding these two immunitary processes and more specifically: (a) the duration of natural immunity; (b) cellular immunity; (c) cross-reactivity; (d) the duration of post-vaccination immune protection; (e) the probability of reinfection and its clinical manifestations in the recovered patients; (f) the comparisons between vaccinated and unvaccinated as to the possib

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Duché, Denis, Aurélie Frenkian, Valérie Prima, and Roland Lloubès. "Release of Immunity Protein Requires Functional Endonuclease Colicin Import Machinery." Journal of Bacteriology 188, no. 24 (2006): 8593–600. http://dx.doi.org/10.1128/jb.00941-06.

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ABSTRACT Bacteria producing endonuclease colicins are protected against the cytotoxic activity by a small immunity protein that binds with high affinity and specificity to inactivate the endonuclease. This complex is released into the extracellular medium, and the immunity protein is jettisoned upon binding of the complex to susceptible cells. However, it is not known how and at what stage during infection the immunity protein release occurs. Here, we constructed a hybrid immunity protein composed of the enhanced green fluorescent protein (EGFP) fused to the colicin E2 immunity protein (Im2) t

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Johnsen, Line, Gunnar Fimland, Dimitris Mantzilas, and Jon Nissen-Meyer. "Structure-Function Analysis of Immunity Proteins of Pediocin-Like Bacteriocins: C-Terminal Parts of Immunity Proteins Are Involved in Specific Recognition of Cognate Bacteriocins." Applied and Environmental Microbiology 70, no. 5 (2004): 2647–52. http://dx.doi.org/10.1128/aem.70.5.2647-2652.2004.

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ABSTRACT The immunity proteins of pediocin-like bacteriocins show a high degree of specificity with respect to the pediocin-like bacteriocin they recognize and confer immunity to. The aim of this study was to identify regions of the immunity proteins that are involved in this specific recognition. Six different hybrid immunity proteins were constructed from three different pediocin-like bacteriocin immunity proteins that have similar sequences but confer resistance to different bacteriocins. These hybrid immunity proteins were then tested for their ability to confer immunity to various pedioci

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Sharma, Prashant, Ji Beom Shin, Bum Chul Park, et al. "Application of radially grown ZnO nanowires on poly-l-lactide microfibers complexed with a tumor antigen for cancer immunotherapy." Nanoscale 11, no. 10 (2019): 4591–600. http://dx.doi.org/10.1039/c8nr08704k.

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Loyal, Lucie, Julian Braun, Ulf Reimer, et al. "Hybrid immunity-based induction of durable pan-endemic-coronavirus immunity in the elderly." Cell Reports 44, no. 2 (2025): 115314. https://doi.org/10.1016/j.celrep.2025.115314.

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Chavda, Vivek P., Suneetha Vuppu, Toshika Mishra, and Pankti Balar. "The Emergence of Hybrid Variants of SARS-CoV-2: Towards Hybrid Immunity." Vaccines 11, no. 4 (2023): 764. http://dx.doi.org/10.3390/vaccines11040764.

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Bhattacharya, Madhumita, and Taraprasad Chattopadhyay. "Interference-Immunity of the Injection-Locked Hybrid Discriminator." IETE Journal of Research 40, no. 2-3 (1994): 69–73. http://dx.doi.org/10.1080/03772063.1994.11437171.

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Roza, Des. "INCREASE OF IMMUNITY CANTIK HYBRID GROUPER JUVENILES BY LIPOPOLYSACCHARIDE (LPS)." Jurnal Ilmu dan Teknologi Kelautan Tropis 9, no. 1 (2017): 161–72. http://dx.doi.org/10.29244/jitkt.v9i1.17927.

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Disease is one of obstacle in fish culture. Immunity of fish against disease can be increased by using immunostimulant. The purpose of this experiment to increasing immunity of cantik hybrid grouper (cross breeding of tiger grouper, Epinephelus fuscoguttatus female with marbled grouper, E. polyphekadion male) to the diseases by using immunostimulant. Treatments were LPS cell walls of V. alginolyticus and commercial LPS was also used in this study, as a-control without LPS was used saline water (0.85% NaCl). The LPS was delivered by injection intra-muscularly with concentration of 0.1 mL/fish.

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Spreco, Armin, Örjan Dahlström, Anna Jöud, et al. "Effectiveness of the BNT162b2 mRNA Vaccine Compared with Hybrid Immunity in Populations Prioritized and Non-Prioritized for COVID-19 Vaccination in 2021–2022: A Naturalistic Case-Control Study in Sweden." Vaccines 10, no. 8 (2022): 1273. http://dx.doi.org/10.3390/vaccines10081273.

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The term hybrid immunity is used to denote the immunological status of vaccinated individuals with a history of natural infection. Reports of new SARS-CoV-2 variants of concern motivate continuous rethought and renewal of COVID-19 vaccination programs. We used a naturalistic case-control study design to compare the effectiveness of the BNT162b2 mRNA vaccine to hybrid immunity 180 days post-vaccination in prioritized and non-prioritized populations vaccinated before 31 July 2021 in three Swedish counties (total population 1,760,000). Subjects with a positive SARS-CoV-2 test recorded within 6 mo

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Gujjarlapudi, Deepika, Ankit Mittal, Rupjyoti Talukdar, et al. "COVID-19 vaccination-infection status and immunological profile from India: A case study for prioritizing at risk population for targeted immunization." Journal of Family Medicine and Primary Care 14, no. 7 (2025): 2885–91. https://doi.org/10.4103/jfmpc.jfmpc_1977_24.

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ABSTRACT Background: The COVID-19 pandemic’s global impact was mitigated through rapid vaccine development, leading to a mix of natural and vaccination-derived immunity. The immunological profile in hybrid immunity remains less studied, especially in regions where non-mRNA vaccines were used. This study focuses on the immunological profiles and predictors of immune response in one such population. Methods: This cohort study assessed their humoral and cellular immune responses, breakthrough Omicron infections, and hospitalization rates based on vaccination and infection history. Immunological a

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Russell, Rodney S. "Hybrid Immunity Against Severe Acute Respiratory Syndrome Coronavirus 2." Viral Immunology 35, no. 6 (2022): 391. http://dx.doi.org/10.1089/vim.2022.0116.

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Shervani, Zameer, Deepali Bhardwaj, Roma Nikhat, et al. "Serosurvey of Haryana and Odisha: COVID-19 Hybrid Immunity." European Journal of Medical and Health Sciences 4, no. 2 (2022): 27–32. http://dx.doi.org/10.24018/ejmed.2022.4.2.1173.

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The seroprevalence in Indian states Haryana and Odisha has been investigated. The seropositivity in the Haryana population increased with time from 8% to 14.8% to 76.3% as recorded in August, October 2020, and September 2021, respectively. The virus spread was continuous as the increase in seroprevalence was monotonous. The three COVID-19 pandemic waves that hit Haryana in September, November 2020, and May 2021 infected the population and generated antibodies. The last serosurvey conducted in September 2021 which registered 76.3% seroprevalence might have a contribution from vaccination as 25%

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Diego, Juan García-Bernalt, Gagandeep Singh, Sonia Jangra, et al. "Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian hamsters." PLOS Pathogens 20, no. 1 (2024): e1011805. http://dx.doi.org/10.1371/journal.ppat.1011805.

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Hybrid immunity (vaccination + natural infection) to SARS-CoV-2 provides superior protection to re-infection. We performed immune profiling studies during breakthrough infections in mRNA-vaccinated hamsters to evaluate hybrid immunity induction. The mRNA vaccine, BNT162b2, was dosed to induce binding antibody titers against ancestral spike, but inefficient serum virus neutralization of ancestral SARS-CoV-2 or variants of concern (VoCs). Vaccination reduced morbidity and controlled lung virus titers for ancestral virus and Alpha but allowed breakthrough infections in Beta, Delta and Mu-challeng

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Rodriguez Velásquez, Sabina, Loza Estifanos Biru, Sandrine Marie Hakiza, et al. "Long-term levels of protection of different types of immunity against the Omicron variant: a rapid literature review." Swiss Medical Weekly 154, no. 5 (2024): 3732. http://dx.doi.org/10.57187/s.3732.

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INTRODUCTION: With the emergence of newer SARS-CoV-2 variants and their substantial effects on the levels and duration of protection against infection, an understanding of these characteristics of the protection conferred by humoral and cellular immunity can aid in the proper development and implementation of vaccine and safety guidelines. METHODS: We conducted a rapid literature review and searched five electronic databases weekly from 1 November 2021 to 30 September 2022. Studies that assessed the humoral or cellular immunity conferred by infection, vaccination or a hybrid (combination of bo

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Livieratos, Achilleas, Charalambos Gogos, and Karolina Akinosoglou. "Impact of Prior COVID-19 Immunization and/or Prior Infection on Immune Responses and Clinical Outcomes." Viruses 16, no. 5 (2024): 685. http://dx.doi.org/10.3390/v16050685.

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Cellular and humoral immunity exhibit dynamic adaptation to the mutating SARS-CoV-2 virus. It is noteworthy that immune responses differ significantly, influenced by whether a patient has received vaccination or whether there is co-occurrence of naturally acquired and vaccine-induced immunity, known as hybrid immunity. The different immune reactions, conditional on vaccination status and the viral variant involved, bear implications for inflammatory responses, patient outcomes, pathogen transmission rates, and lingering post-COVID conditions. Considering these developments, we have performed a

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Kozlovskiy, Vladimir, Pavel Nikolaev, Alexander Podgorniy, Alexey Kritskiy, and Luiza Shamina. "Experimental studies of a hybrid car and electric car interference immunity." E3S Web of Conferences 221 (2020): 01001. http://dx.doi.org/10.1051/e3sconf/202022101001.

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This article covers a hybrid car interference immunity research. A combined unit-power plant vehicle prototype (a hybrid car) of a famous Russian brand is a subject of this research. Its configuration included a motor control center in boot of a car and a standard internal combustion engine control system (ICE) with upgraded software for joint operation of two power plants.

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Ji, Hongshan, and Zhiguo Zhou. "A ‘Hybrid’ Radiotherapy Regimen Designed for Immunomodulation: Combining High-Dose Radiotherapy with Low-Dose Radiotherapy." Cancers 14, no. 14 (2022): 3505. http://dx.doi.org/10.3390/cancers14143505.

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Radiotherapy (RT) affects anti-tumor immunity. However, the exact impact of RT on anti-tumor immune response differs among cancer types, RT dose and fractions, patients’ innate immunity, and many other factors. There are conflicting findings on the optimal radiation dose and fractions to stimulate effective anti-tumor immunity. High-dose radiotherapy (HDRT) acts in the same way as a double-edged sword in stimulating anti-tumor immunity, while low-dose radiotherapy (LDRT) seems to play a vital role in modulating the tumor immune microenvironment. Recent preclinical data suggest that a ‘hybrid’

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Kurmangaliyeva, Saulesh S., Akzhan M. Madenbayeva, Saltanat T. Urazayeva, Yerlan Sh Bazargaliyev, Khatimya I. Kudabayeva, and Kairat B. Kurmangaliyev. "Comparative Analysis of Vaccine-induced Immunity and Natural Immunity in Post-COVID Patients." West Kazakhstan Medical Journal 66, no. 4 (2024): 387–400. https://doi.org/10.18502/wkmj.v66i4.17770.

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The COVID-19 pandemic has prompted an urgent need to understand the differences between vaccine-induced and natural immunity, particularly in the context of post- COVID syndrome (long COVID). This review compares the immune responses elicited by natural infection and vaccination, focusing on their duration, strength, and effectiveness in mitigating long COVID symptoms. Vaccine-induced immunity, primarily targeting the spike protein of SARS-CoV-2, often produces a more consistent antibody and T-cell response, especially when bolstered by booster doses. In contrast, natural immunity, though broa

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Tikhomirova, K. K., S. M. Kharit, and O. V. Goleva. "Do repeated vaccinations affect the incidence of coronavirus infection?" Journal Infectology 17, no. 2 (2025): 73–79. https://doi.org/10.22625/2072-6732-2025-17-2-73-79.

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Coronavirus infection caused by the SARS-CoV-2 virus is becoming one of the seasonal respiratory infections, which requires a decision on the continuation of vaccination for certain groups of people.The purpose: To study the relationship between the clinical and immunological efficacy of vaccination and revaccination against COVID-19 in people of different ages, health conditions and occupational risk.Research methods: Clinical observation of 258 adults who were vaccinated and revaccinated, as well as those with hybrid immunity, in a catamnesis for 2 years after vaccination with an assessment

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Barbieri, Elisa, Nhung T. H. Trinh, Costanza Di Chiara, et al. "Impact of Prior SARS-CoV-2 Infection on COVID-19 Vaccine Effectiveness in Children and Adolescents in Norway and Italy." Vaccines 13, no. 7 (2025): 698. https://doi.org/10.3390/vaccines13070698.

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Background and objective: The approval of mRNA-based vaccines for children and adolescents has contributed to global efforts to control the SARS-CoV-2 pandemic. While hybrid immunity—combining prior SARS-CoV-2 infection and vaccination—may offer enhanced protection, data on its effectiveness versus vaccine-induced immunity in the pediatric population are limited. Methods: This retrospective matched cohort study used linked health data from Norwegian nationwide health registries and the Italian Pedianet network. The study included children and adolescents aged 5–14 years eligible for COVID-19 v

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Shenoy, Padmanabha, Sakir Ahmed, Aby Paul, et al. "Hybrid immunity versus vaccine-induced immunity against SARS-CoV-2 in patients with autoimmune rheumatic diseases." Lancet Rheumatology 4, no. 2 (2022): e80-e82. http://dx.doi.org/10.1016/s2665-9913(21)00356-8.

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E. A. Imelbaeva, E. A., A. Zh Gilmanov, and L. M. Saptarova. "Results of assessing herd immunity to SARS-CoV-2 in medical workers." Terapevt (General Physician), no. 10 (October 27, 2023): 6–11. http://dx.doi.org/10.33920/med-12-2310-01.

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article presents the results of a study of the level of antibodies to SARSCoV- 2 in the blood of 54 medical workers: those who were ill or vaccinated within six months before the start of the study (70.4 %), non-ill and unvaccinated (20.7 %), and those with hybrid immunit y (recovered from the disease and vaccinated) (6.9 %). The data obtained indicate a decrease in the level of herd immunity within six months, which is especially pronounced in non-immunized individuals. The presence of antibodies in low titers in non-ill and non-immunized individuals may indicate natural immunization in the c

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Chen, Jonathan, Linda Nieman, Maxwell Spurrell, Justin Gainor, and Nir Hacohen. "Abstract 5784: Spatial clustering reveals immune hub interaction with reservoir of stem-like CD8 T cells and predicts immunotherapy response in lung cancer patients." Cancer Research 83, no. 7_Supplement (2023): 5784. http://dx.doi.org/10.1158/1538-7445.am2023-5784.

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Abstract Background: Immunologic tumor control involves coordination of multiple cell types, but the organization of these interactions in human tumors is poorly understood. We recently reported that immunogenic tumors contain spatially-localized multicellular immunity hubs characterized by expression of interferon-stimulated genes, including CXCL10/CXCL11 (T cell attracting chemokines), and the presence of IFNG+ T cells. This suggested a positive feedback loop where T cell-derived IFNγ stimulates production of CXCR3 ligands, thereby attracting more T cells. However, we did not know (1) whethe

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Liu, Zihui, Binglin Chen, Zhiying Zou, et al. "Non-Additive and Asymmetric Allelic Expression of p38 mapk in Hybrid Tilapia (Oreochromis niloticus ♀ × O. aureus ♂)." Animals 14, no. 2 (2024): 266. http://dx.doi.org/10.3390/ani14020266.

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Hybridization is a widely used breeding technique in fish species that enhances desirable traits in cultured species through heterosis. However, the mechanism by which hybrids alter gene expression to form heterosis remains unclear. In this study, a group of hybrid tilapia was used to elucidate heterosis through interspecies crossing. Specifically, p38 was analyzed to describe the regulation of gene expression variation in hybrid tilapia. Transcripts from the Nile tilapia allele were found to be significantly higher than those from the blue tilapia allele in hybrid individuals, indicating that

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Xiao, Wei, Binglin Chen, Jun Wang, et al. "Integration of mRNA and miRNA Profiling Reveals Heterosis in Oreochromis niloticus × O. aureus Hybrid Tilapia." Animals 12, no. 5 (2022): 640. http://dx.doi.org/10.3390/ani12050640.

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Heterosis is a widespread biological phenomenon in fishes, in which hybrids have superior traits to parents. However, the underlying molecular basis for heterosis remains uncertain. Heterosis in growth and survival rates is apparent in hybrid tilapia (Oreochromis niloticus ♀ × O. aureus ♂). Comparisons of growth and hematological biochemical characteristics and mRNA and miRNA transcriptional analyses were performed in hybrid and parents tilapia stocks to investigate the underlying molecular basis for heterosis. Growth characteristics and hematological glucose and cholesterol parameters were si

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Spinardi, Julia R., and Amit Srivastava. "Hybrid Immunity to SARS-CoV-2 from Infection and Vaccination—Evidence Synthesis and Implications for New COVID-19 Vaccines." Biomedicines 11, no. 2 (2023): 370. http://dx.doi.org/10.3390/biomedicines11020370.

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COVID-19 has taken a severe toll on the global population through infections, hospitalizations, and deaths. Elucidating SARS-CoV-2 infection-derived immunity has led to the development of multiple effective COVID-19 vaccines and their implementation into mass-vaccination programs worldwide. After ~3 years, a substantial proportion of the human population possesses immunity from infection and/or vaccination. With waning immune protection over time against emerging SARS-CoV-2 variants, it is essential to understand the duration of protection, breadth of coverage, and effects on reinfection. This

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JOLY, P., V. GUESDON, E. FROMONT, et al. "Heterozygosity and parasite intensity: lung parasites in the water frog hybridization complex." Parasitology 135, no. 1 (2007): 95–104. http://dx.doi.org/10.1017/s0031182007003599.

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SUMMARYIn hybridogenetic systems, hybrid individuals are fully heterozygous because one of the parental genomes is discarded from the germinal line before meiosis. Such systems offer the opportunity to investigate the influence of heterozygosity on susceptibility to parasites. We studied the intensity of lung parasites (the roundwormRhabdias bufomisand the flukeHaplometra cylindracea) in 3 populations of water frogs of theRana lessonae-esculentacomplex in eastern France. In these mixed populations, hybrid frogs (R. esculenta) outnumbered parental ones (R. lessonae). Despite variation in parasi

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Roza, Des. "INCREASE OF IMMUNITY CANTIK HYBRID GROUPER JUVENILES BY LIPOPOLYSACCHARIDE (LPS)." Jurnal Ilmu dan Teknologi Kelautan Tropis 9, no. 1 (2017): 161. http://dx.doi.org/10.28930/jitkt.v9i1.17927.

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<p><em>Disease is one of obstacle in fish culture. Immunity of fish against disease can be increased by using immunostimulant. The purpose of this experiment to increasing immunity of cantik hybrid grouper (cross breeding of tiger grouper</em><em>, Epinephelus fuscoguttatus female with marbled grouper, E. polyphekadion male) to the diseases by using immunostimulant.</em><em> </em><em>Treatments were LPS cell walls of <span style="text-decoration: underline;">V.</span> <span style="text-decoration: underline;">alginolyticus</s

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Goldblatt, David. "SARS-CoV-2: from herd immunity to hybrid immunity." Nature Reviews Immunology, April 19, 2022. http://dx.doi.org/10.1038/s41577-022-00725-0.

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Rothoeft, T., C. Maier, A. Talarico, et al. "Natural and hybrid immunity after SARS-CoV-2 infection in children and adolescents." Infection, March 18, 2024. http://dx.doi.org/10.1007/s15010-024-02225-w.

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Abstract Purpose In contrast to adults, immune protection against SARS-CoV-2 in children and adolescents with natural or hybrid immunity is still poorly understood. The aim of this study was to analyze different immune compartments in different age groups and whether humoral immune reactions correlate with a cellular immune response. Methods 72 children and adolescents with a preceding SARS-CoV-2 infection were recruited. 37 were vaccinated with an RNA vaccine (BNT162b2). Humoral immunity was analyzed 3–26 months (median 10 months) after infection by measuring Spike protein (S), nucleocapsid (

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Frans, Glynis, Doreen Dillaerts, Tom Dehaemers, et al. "Complementarity determining regions in SARS-CoV-2 hybrid immunity." Frontiers in Immunology 14 (February 21, 2023). http://dx.doi.org/10.3389/fimmu.2023.1050037.

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Pre-vaccination SARS-CoV-2 infection can boost protection elicited by COVID-19 vaccination and post-vaccination breakthrough SARS-CoV-2 infection can boost existing immunity conferred by COVID-19 vaccination. Such ‘hybrid immunity’ is effective against SARS-CoV-2 variants. In order to understand ‘hybrid immunity’ at the molecular level we studied the complementarity determining regions (CDR) of anti-RBD (receptor binding domain) antibodies isolated from individuals with ‘hybrid immunity’ as well as from ‘naive’ (not SARS-CoV-2 infected) vaccinated individuals. CDR analysis was done by liquid c

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Bausch-Jurken, Mary, and Galit Alter. "The immunological impact of revaccination in a hybrid-immune world." Frontiers in Immunology 16 (June 9, 2025). https://doi.org/10.3389/fimmu.2025.1588259.

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The global immune landscape of SARS-CoV-2 has progressively shifted from a naïve population several years ago to a population that possesses immunity to the virus through infection, vaccination, or a combination of both, known as hybrid immunity. Hybrid immunity offers a prolonged period of transmission-blocking activity, likely related to enhanced tissue-resident immunity, but also has been shown to be linked to broader humoral and cellular immune responses. Compared with vaccination or infection alone, the collective data have demonstrated that hybrid immunity offers enhanced protection agai

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Lupton, Deborah. "Immunities in the COVID age: a sociomaterial and more-than-human perspective." Social Theory & Health 23, no. 1 (2025). https://doi.org/10.1057/s41285-025-00224-x.

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Abstract Since the outbreak of the COVID-19 pandemic, the topic of human immunity has received intense attention in the scientific literature and public forums: often in contested, highly politicised and confusing ways. A plethora of terms involving immunity have appeared in news reports, government announcements and academic articles: herd immunity, hybrid immunity, immunity gap, immunity debt, immunity theft, immunity evasion, immunity escape and immunity wall. In this essay, I discuss the diverse discourses, logics, practices and biopolitics of contemporary representations and understanding

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Uusküla, Anneli, Heti Pisarev, Anna Tisler, et al. "Risk of SARS-CoV-2 infection and hospitalization in individuals with natural, vaccine-induced and hybrid immunity: a retrospective population-based cohort study from Estonia." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-47043-6.

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AbstractA large proportion of the world’s population has some form of immunity against SARS-CoV-2, through either infection (‘natural’), vaccination or both (‘hybrid’). This retrospective cohort study used data on SARS-CoV-2, vaccination, and hospitalization from national health system from February 2020 to June 2022 and Cox regression modelling to compare those with natural immunity to those with no (Cohort1, n = 94,982), hybrid (Cohort2, n = 47,342), and vaccine (Cohort3, n = 254,920) immunity. In Cohort 1, those with natural immunity were at lower risk for infection during the Delta (aHR 0.

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Boyton, Rosemary J., and Daniel M. Altmann. "Imprinted hybrid immunity against XBB reinfection." Lancet Infectious Diseases, March 2023. http://dx.doi.org/10.1016/s1473-3099(23)00138-x.

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The Lancet Infectious Diseases. "Why hybrid immunity is so triggering." Lancet Infectious Diseases, November 2022. http://dx.doi.org/10.1016/s1473-3099(22)00746-0.

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Altarawneh, Heba N., Hiam Chemaitelly, Houssein H. Ayoub, et al. "1966. Protection afforded by prior infection, vaccination, and hybrid immunity against symptomatic BA.1 and BA.2 Omicron infections." Open Forum Infectious Diseases 9, Supplement_2 (2022). http://dx.doi.org/10.1093/ofid/ofac492.1591.

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Abstract Background Protection offered by five different forms of immunity, combining natural and vaccine immunity, was investigated against symptomatic SARS-CoV-2 infection from Omicron BA.1 or BA.2, and severe, critical, or fatal COVID-19 from BA.1 or BA.2, in Qatar, between December 23, 2021 and February 21, 2022. Methods Six national, matched, test-negative case-control studies were conducted on a sample of 272,861 PCR-positive tests and 669,628 PCR-negative tests to estimate effectiveness of BNT162b2 (Pfizer-BioNTech) vaccine, mRNA-1273 (Moderna) vaccine, natural immunity due to prior inf

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Guedalia, Joshua, Michal Lipschuetz, Adva Cahen-Peretz, et al. "Maternal hybrid immunity and risk of infant COVID-19 hospitalizations: national case-control study in Israel." Nature Communications 15, no. 1 (2024). http://dx.doi.org/10.1038/s41467-024-46694-x.

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AbstractHybrid immunity, acquired through vaccination followed or preceded by a COVID-19 infection, elicits robust antibody augmentation. We hypothesize that maternal hybrid immunity will provide greater infant protection than other forms of COVID-19 immunity in the first 6 months of life. We conducted a case-control study in Israel, enrolling 661 infants up to 6 months of age, hospitalized with COVID-19 (cases) and 59,460 age-matched non-hospitalized infants (controls) between August 24, 2021, and March 15, 2022. Infants were grouped by maternal immunity status at delivery: Naïve (never vacci

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Yang, Li, Pengtao Liu, Xuncheng Wang, et al. "A central circadian oscillator confers defense heterosis in hybrids without growth vigor costs." Nature Communications 12, no. 1 (2021). http://dx.doi.org/10.1038/s41467-021-22268-z.

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AbstractPlant immunity frequently incurs growth penalties, which known as the trade-off between immunity and growth. Heterosis, the phenotypic superiority of a hybrid over its parents, has been demonstrated for many traits but rarely for disease resistance. Here, we report that the central circadian oscillator, CCA1, confers heterosis for bacterial defense in hybrids without growth vigor costs, and it even significantly enhances the growth heterosis of hybrids under pathogen infection. The genetic perturbation of CCA1 abrogated heterosis for both defense and growth in hybrids. Upon pathogen at

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den Hartog, Gerco, Stijn P. Andeweg, Christina E. Hoeve, et al. "Assessment of hybrid population immunity to SARS-CoV-2 following breakthrough infections of distinct SARS-CoV-2 variants by the detection of antibodies to nucleoprotein." Scientific Reports 13, no. 1 (2023). http://dx.doi.org/10.1038/s41598-023-45718-8.

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AbstractImmunity induced by vaccination and infection, referred to as hybrid immunity, provides better protection against SARS-CoV-2 infections compared to immunity induced by vaccinations alone. To assess the development of hybrid immunity we investigated the induction of Nucleoprotein-specific antibodies in PCR-confirmed infections by Delta or Omicron in vaccinated individuals (n = 520). Eighty-two percent of the participants with a breakthrough infection reached N-seropositivity. N-seropositivity was accompanied by Spike S1 antibody boosting, and independent of vaccination status or virus v

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Calvo-Baltanás, Vanesa, Jinge Wang, and Eunyoung Chae. "Hybrid Incompatibility of the Plant Immune System: An Opposite Force to Heterosis Equilibrating Hybrid Performances." Frontiers in Plant Science 11 (February 16, 2021). http://dx.doi.org/10.3389/fpls.2020.576796.

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Hybridization is a core element in modern rice breeding as beneficial combinations of two parental genomes often result in the expression of heterosis. On the contrary, genetic incompatibility between parents can manifest as hybrid necrosis, which leads to tissue necrosis accompanied by compromised growth and/or reduced reproductive success. Genetic and molecular studies of hybrid necrosis in numerous plant species revealed that such self-destructing symptoms in most cases are attributed to autoimmunity: plant immune responses are inadvertently activated in the absence of pathogenic invasion.

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