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Rozprawy doktorskie na temat „Hypercholesteremia”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Staples, Heidi. "The effect of lipid-lowering pharmacotherapy on concurrent diet and exercise behaviors /." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=31543.

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The National Cholesterol Education Program Adult Treatment Panel II (NCEP ATP II) unequivocally advocates an initial trial of dietary modification in both primary and secondary prevention prior to the institution of pharmacotherapy. Perhaps the rationale for this delay rests in the inherent, yet unsubstantiated, fear among clinicians that lifestyle change will be compromised in the presence of concurrent pharmacotherapy. However, the question of adherence to diet and exercise interventions following the initiation of lipid-lowering drug therapy has seemingly never been addressed scientifically

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Collins, Melissa. "Effects of plant sterols and exercise training on apolipoprotein A and B, adiponectin, growth hormone and ghrelin in hypercholesterolemic sedentary adults." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=99331.

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Plant sterols (PS) lower total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and inflammatory markers, and decrease risk of atherosclerotic cardiovascular disease (CVD). Exercise increases high density lipoprotein cholesterol (HDL-C) levels and decreases triglycerides (TG) and inflammation, also reducing the risk of CVD. The study objective was to investigate the combined effects of PS and exercise on apolipoproteins (apo) A and B, adiponectin, growth hormone (GH) and ghrelin, in context of previously obtained lipid data. In an 8-wk, placebo-controlled, parallel-arm clinical t

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Vergotine, Joseph Vincent. "The MED-PED project : presymptomatic diagnosis in families with disease- related LDL receptor gene mutations." Thesis, Stellenbosch : Stellenbosch University, 2000. http://hdl.handle.net/10019.1/51997.

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Thesis (MSc)--Stellenbosch University, 2000.<br>ENGLISH ABSTRACT: Familial hypercholesterolaemia (FH) contributes significantly to the high death rate from cardiovascular disease worldwide. FH is a common autosomal co-dominant disease characterised by raised cholesterol levels and premature coronary heart disease (CHD). Whilst these features usually are very prominent in homozygotes the clinical diagnosis of heterozygotes is complicated by variable phenotypic expression. Specific founder genes in the low-density lipoprotein receptor (LDLR) gene have increased the prevalence of FH in So

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4

Wong, Kwok-kit Sunny. "A study of DNA mutations in LDL receptor gene of Chinese patients with familial hypercholesterolaemia /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19109878.

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St-Onge, Marie-Pierre. "Effect of kefir supplementation on blood lipid parameters in free-living hypercholesterolemic men." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0024/MQ50885.pdf.

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Miller, Stephanie M. "The Relationship of Waist Size to Blood Pressure and Cholesterol Among College Students." Lynchburg, Va. : Liberty University, 2007. http://digitalcommons.liberty.edu.

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Yang, Tat-chi Teddy. "Effect of Chinese green tea on diet-induced hypercholesterolemia and arteriosclerosis in rats /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19657560.

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8

Neubauer, Tamara E. "Cholesterol reduction in men : an experimental investigation of intensive treatment with frequent feedback versus a simple educational treatment /." Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03122009-040807/.

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Matthan, Nirupa Rachel. "Impact of hydrogenated fat consumption on in vivo lipid metabolism in moderately hypercholesterolemic women." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0033/NQ64617.pdf.

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Fourie, Anne Madeleine. "The expression and metabolism of low density lipoprotein receptors in familial hypercholesterolaemia." Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/27174.

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The expression of two phenotypically-contrasting LDL receptor mutations was characterized in cultured fibroblasts from the genetically-homozygous Afrikaner subjects, FH1a and lb, and FH3a and 3b, respectively. Surface receptor expression and functional activity were studied by ligand (¹²⁵I-LDL) and monoclonal antibody (¹²⁵I-IgG-C7) binding, and c35s]-methionine pulse-chase experiments were used to analyze biosynthesis, processing and degradation of IgG-C7- immunoprecipitable mutant receptors. Cells from the "receptor-negative" subjects, FH3a and 3b exhibited reduced, but significant (40-60% of

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11

Chan, Yen-Ming 1980. "The effect of fatty acid composition of plant sterol esters on blood lipid profiles and plasma plant sterol levels in hypercholesterolemic subjects /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=97923.

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To evaluate the relative efficacy of plant sterols (PS) esterified with the fatty acids from fish oil (PS-FO), olive oil (PS-OO) and sunflower oil (PS-SO) on blood lipid and PS concentrations, 21 hyperlipidemic subjects were randomly assigned to each of five treatments for 28 days using a cross-over design. The results showed that: (1) in a comparison of olive oil (OO), fish oil (FO), PS-FO and PS-SO subgroup, PS-FO reduced triacylglycerols (TG) relative to PS-SO. Total cholesterol (T-C)/high-density lipoprotein cholesterol (HDL-C) ratio was reduced with PS-FO compared with FO. Plasma PS level

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12

Houweling, Adrielle H. "Efficacy of plant sterol treatment in individuals with high or low baseline levels of circulating plasma plant sterols." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101141.

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Plant sterols are effective cholesterol-lowering agents; however, recent evidence suggests that this treatment may not be safe and beneficial in all individuals. This study determined whether high and low baseline circulating plasma campesterol and sitosterol are related to subsequent changes in plasma LDL-C, plant sterol or CRP levels, after accounting for plant sterol supplementation in hypercholesterolemic men (n=82). This trial was a 2-phase randomized cross-over design consisting of a controlled diet with and without a dose of 2.0 g/d of plant sterols over 4 weeks. There was no significan

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13

楊達志 and Tat-chi Teddy Yang. "Effect of Chinese green tea on diet-induced hypercholesterolemia and arteriosclerosis in rats." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31237939.

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Hernandes, Dorival Blaquer. "Estudo comparativo dos efeitos da rosuvastatina e atorvastatina nos lipides plasmaticos, peroxidação lipidica e função endotelial em coelhos hipercolesterolemicos." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309182.

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Orientador: Eros Antonio de Almeida<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-10T01:47:47Z (GMT). No. of bitstreams: 1 Hernandes_DorivalBlaquer_M.pdf: 1038635 bytes, checksum: f87a9f0cf9cca81b3827e6b7fefdbb9b (MD5) Previous issue date: 2007<br>Resumo: Objetivo: este estudo teve como objetivo detectar o efeito da rosuvastatina sobre os lípides plasmáticos, peroxidação lipídica, colesterol tecidual e disfunção endotelial e comparar seus efeitos com a atorvastatina em coelhos hipercolesterolêmicos. Métodos

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15

Varady, Kristina A. "Effect of plant sterol supplementation and endurance training on cardiovascular disease risk parameters and cholesterol kinetics in previously sedentary hypercholesterolemic adults." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111831.

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Background. A high ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, in addition to increased levels of small low-density lipoprotein (LDL) particles, are important indicators of cardiovascular disease risk. Therefore, interventions that combine the lowering of total cholesterol and raising of HDL cholesterol concentrations that also increase LDL particle size, may be preventive against cardiovascular disease. Plant sterols decrease total cholesterol and LDL cholesterol levels by 10-15%, while exercise increases HDL cholesterol levels by 4-22%. In view of their compleme

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16

Vanstone, Catherine A. "Influence of phytosterols versus phytostanols on plasma lipid levels and cholesterol metabolism in hypercholesterolemic humans." Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33854.

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The objective of this research was to examine the effects of sitosterol and sitostanol supplementation on plasma cholesterol levels and cholesterol metabolism in hypercholesterolemic subjects consuming a fixed foods diet in a four-phase crossover design. It was hypothesized that addition of either phytosterols, phytostenols, or a 50:50 mixture of sterols and stanols to butter would reduce circulating cholesterol levels, despite butter's hypercholesterolemic effect, through actions involving cholesterol absorption, synthesis, and turnover rates. The data obtained indicate that in their free, un

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17

Olorunnisola, Olubukola Sinbad. "Biochemical evaluation of Tulbaghia violacea harv.rhizomes in diet induced hypercholestrolemic rats." Thesis, University of Fort Hare, 2012. http://hdl.handle.net/10353/d1006900.

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Discovery of cheap, nontoxic and readily available antiatherosclerotic drugs is an extraordinary challenge in this modern world. Atherosclerosis and cardiovascular diseases have been predicted to be the leading cause of death by the year 2030. Hence, this thesis was designed to search for plant (s) with anti-atherogenic properties, investigate its possible side effects and extrapolate its likely mechanism(s) of action. An ethnobotanical survey was employed in identification of locally important plants used for the management and treatment of cardiovascular diseases and its predisposing factors

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Hill, John Stuart. "Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28810.

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Familial hypercholesterolemia (FH) is an autosomal dominant disorder in which the primary defect is a mutation in the LDL receptor. Heterozygous FH is among the most common inborn errors of metabolism and remains as the best example of an inherited defect causing premature coronary artery disease (CAD). This thesis describes the physical and biochemical characteristics of heterozygous FH in a large cohort consisting of 208 women and 156 men. The influence of both genetic and environmental factors on the clinical expression of FH were investigated to better understand the phenotypic variation

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19

Aktürk, Onur Altuntaş İrfan. "Hiperkolesterolemi oluşturulan ratlarda, HMGCoA redüktaz inhibitörü ilaçlarla (Statinler) tedavinin hipokampal NMDA reseptörü subunitlerine etkisi /." Isparta : SDÜ Tıp Fakültesi, 2006. http://tez.sdu.edu.tr/Tezler/TT00294.pdf.

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Journoud, Mélanie. "The effect of plant sterols on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with type 2 diabetes compared with non-diabetic controls /." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80296.

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The objective of this study was to compare the effect of phytosterols (PS) on lipid profiles and cholesterol kinetics of hypercholesterolemic individuals with or without type 2 diabetes. It was hypothesised that the response to PS would differ between both groups due to different lipid metabolism. During this randomised, double blind, crossover trial, participants consumed a controlled diet with placebo or PS for 21 days.<br>Plasma total cholesterol (TC) decreased with placebo and PS (10.9% and 9.7% in non-diabetic versus 11.6% and 13.6% in diabetic participants, p < 0.05). Plasma low-d

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Donckers-Roseveare, Kathryn. "Periodic feedback to reduce cholesterol levels." Thesis, Virginia Tech, 1990. http://hdl.handle.net/10919/41912.

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Wong, Kwok-kit Sunny, and 黃國傑. "A study of DNA mutations in LDL receptor gene of Chinese patients withfamilial hypercholesterolaemia." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31220083.

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Volk, Catherine B. "Role of inhibition of protein prenylation in the cholesterol-dependent and cholesterol-independent effects of simvastatin." Virtual Press, 2006. http://liblink.bsu.edu/uhtbin/catkey/1339597.

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Statins are widely used to treat hypercholesterolemia. Statins inhibit cholesterol biosynthesis, thereby activating genes involved in cholesterol homeostasis, which are under the control of the Sterol Regulatory Element (SRE). Statins also have cholesterol-independent beneficial cardiovascular effects mediated through the phosphoinositide 3-kinase (PI3-K) / Akt signaling pathway and by inhibition of protein prenylation. Because statins inhibit the synthesis of isoprenoids, they can act by inhibiting the small signaling GTPases Ras and Rho, which require post-translational prenylation to become

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24

Scholtz, C. L. (Charlotte Latitia). "Molecular investigation into regulatory regions of the LDLR gene involved in lipoprotein metabolism." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52345.

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Thesis (PhD) -- University of Stellenbosch, 2001.<br>ENGLISH ABSTRACT: The advent of the new millennium saw the complete sequencing of the entire human genome. Only approximately 30 000 genes, much less than was initially predicted, have been identified to be responsible for the genetic diversity in humans. This discovery has prompted a shift in the approach to disease research, since one gene can be involved in numerous diseases. This phenomenon seems to be especially true for the low-density lipoprotein receptor (LDLR) gene. Various substances beside sterols can induce transcription of

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Carr, Timothy Perry. "Copper deficiency-induced hypercholesterolemia: In vivo catabolism of high density lipoprotein cholesteryl ester and protein moities in the rat." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184690.

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Two studies were conducted to determine how HDL cholesteryl ester and apoprotein catabolism might contribute to the observed hypercholesterolemia of copper-deficient rats. Weanling male Sprague-Dawley rats were divided into two dietary treatments; copper-adequate (control, 5-7 mg Cu/kg diet) and copper-deficient (0.6-0.8 mg Cu/kg diet). Deionized water and diet were provided ad libitum. Dietary copper deficiency resulted in enlarged intravascular pools of HDL cholesteryl esters and total protein. HDL were isolated from rats of both treatment groups, radiolabeled, and injected into animals of t

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Jia, Xiaoming 1978. "Efficiency and mechanisms of different phytosterol analogs on lipid profiles and colonic mucosal cell proliferation in hamsters." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84098.

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The current study examined the impact of plant sterols, stanols, sterol esters, and stanol esters on (i) cholesterol-lowering efficiency, (ii) gene expression of ABCG5 and ABCG8 sterol transporters in the liver and small intestine, and (iii) colon mucosal cell proliferation in hamsters. After 5 weeks on experimental diets, plasma total cholesterol levels were reduced ( P<0.05) by stanols, sterol esters and stanol esters compared to cholesterol-control diet. Different PS analogs did not alter ABCG5 and ABCG8 mRNA levels in small intestine and liver as compared to cholesterol control. In

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Lau, Vivian Wai Yan 1977. "Effects of plant sterols on plasma lipid profiles, glycemic control of hypercholesterolemic individuals with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80312.

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Plant sterols (PS) are effective in reducing plasma lipid concentrations, however, few studies have examined their cholesterol lowering effects in type 2 diabetics. The objective was to assess whether PS consumption alters blood lipid profile in hypercholesterolemic subjects with and without type 2 diabetes. Fifteen control subjects (age = 55.1 +/- 8.5 yr and BMI = 26.9 +/- 3.0kg/m2) and fourteen diabetic subjects (age = 54.5 +/- 6.7 yr and BMI = 30.2 +/- 3.0kg/m2) participated in a double-blinded, randomized, crossover, placebo-controlled feeding trial. The Western diet included either

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Barake, Roula. "Effects of plant sterols and glucomannan on parameters of cholesterol kinetics in hyperlipidemic individuals with and without type 2 diabetes." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=83964.

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The objective of this study was to examine the effects of plant sterols and/or glucomannan on lipid profiles and cholesterol kinetics in hyperlipidemic individuals with or without type 2 diabetes. It was hypothesized that plant sterols and glucomannan reduce circulating cholesterol levels and may have an additive or synergistic effect when combined by reducing cholesterol absorption. Thirteen type 2 diabetics and sixteen non-diabetics all mildly hypercholesterolemic free living subjects participated in a randomized crossover trial consisting of 4 phases, 21 days each. Subjects consumed

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Roynette, Catherine E. "Effects of a functional oil rich in medium chain triglycerides and phytosterols on plasma lipid profiles and body composition in hypercholesterolemic, overweight men." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84069.

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Localised accumulation of body fat significantly influences the development of obesity related co-morbidities and cardiovascular disease (CVD) risk. Medium chain triglycerides (MCT) have been suggested to modulate body fat distribution. Phytosterols (PS) have demonstrated unequivocal cholesterol-lowering effects. A healthy dietary solution combining MCT and PS could thus become first-line obesity and CVD prevention. The aim of this study was therefore to investigate the effects of a functional oil (FctO) rich in MCT and PS on blood lipid levels and body adiposity, compared to olive oil.

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Yoshida, Makiko. "Plant sterols and glucomannan as hypocholesterolemic and hypoglycemic agents in subjects with and without type 2 diabetes." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=80900.

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The objective of this research was to examine the effects of plant sterols and glucomannan on lipid profiles, plasma plant sterol levels and glycemic control in mildly hypercholesterolemic subjects. Thirteen type 2 diabetic and sixteen non-diabetic individuals participated in a randomized crossover trial consisting of 4 phases, of 21 days each. During the study period, subjects were supplemented with plant sterols and/or glucomannan. Overall reductions of total cholesterol and low-density lipoprotein (LDL) cholesterol concentrations were greater after consumption of plant sterols and gl

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Escate, Chávez Oscar Rafael. "Efectos de la hipercolesterolemia sobre monocitos/macrófagos y la inmunidad innata." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/400218.

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La enfermedad cardiovascular sigue siendo la principal causa de morbilidad y mortalidad en todo el mundo. La inmensa mayoría de los eventos cardiovasculares incluyendo los síndromes coronarios y accidente cerebrovascular son la causa por la rotura o erosión de las placas de ateroma en la pared arterial. La aterosclerosis es una enfermedad compleja dinámica caracterizada por la infiltración de lípidos en la pared arterial y una respuesta inflamación crónica por las células del sistema inmune innato, principalmente monocitos y macrófagos. Los altos niveles circulantes de lipoproteínas de baja de

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Peterson, Carla A. "Effects of the National School Lunch Program and the School Breakfast Program on cholesterol levels of children ages 11-15." Virtual Press, 1999. http://liblink.bsu.edu/uhtbin/catkey/1125148.

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This study looked at how cholesterol levels of students, ages 11-15, who participated in the NSLP and the SBP would be affected compared with those students who only participated in the NSLP. Fasting blood samples (lOmL) were analyzed from 15 students who ate lunch only (L) and 15 students who ate both breakfast and lunch (BL) from the Driver Middle School food service at least 3 times a week. Blood was analyzed for changes in total cholesterol, HDL, LDL, and Triglycerides from baseline to 4 months. Results showed a significant decrease in total cholesterol and LDL, and a significant increase

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Vilaplana, Saiz Marta. "Design and synthesis of new potentially inhibitors of PCSK9 and KRAS proteins." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673609.

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This thesis shows the research carried out on two specific diseases: familial hypercholesterolemia, which is included within the cardiovascular diseases group, and cancer. These diseases are the major cause of deaths in Spain and worldwide. The study of familial hypercholesterolemia is of great interest, as it is mainly caused by a protein called PCSK9 whose atypical functioning leads to an increase of LDL-C in blood. Thus, the study of new diseases results in the study of new therapeutic targets. Therefore, a thorough investigation on the PCSK9 protein has been conducted by means of molecular

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Viljoen, Janet Erica. "Strength training and cardiovascular risk post-menses, with particular emphasis on the plasma lipoproteins: a controlled trial." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1013578.

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Introduction: Cardiovascular disease affects a greater proportion of females than it does males, and is responsible for an estimated 52 percent of female deaths per annum, globally. Due to the loss of oestrogen associated with the menopause, post-menopausal females are at elevated risk for hypercholesterolaemia which is a primary risk factor for cardiovascular disease. It has not yet been conclusively established whether resistance training can be used to ameliorate hypercholesterolaemia. Aim: This randomized controlled trial investigated what effect 12 weeks of progressive resistance training

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Romero, Sandoval July Carolina. "Implicación de LRP5 en la enfermedad cardiovascular." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285119.

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Atherosclerosis is an inflammatory process characterized by the accumulation of lipids and fibrous elements in large arteries. It is the main underlying pathological process leading to heart attack and stroke. Low-density-lipoprotein Receptor-related Protein 5 (LRP5) functions as a co-receptor with Frizzled for extracellular Wnt glycoproteins to trigger the canonical Wnt pathway. It regulates multiple cellular processes including cell differentiation, inflammation, carcinogenesis, fibrosis, and angiogenesis. We studied the role of LRP5 and the canonical Wnt signaling pathway in atherosclerosis

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Jackson, Lindsay May. "Male and female cardiovascular risk in an urban, black working population." Thesis, Rhodes University, 2011. http://hdl.handle.net/10962/d1005205.

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The aim of this research project was to assess and compare cardiovascular disease (CVD) risk in black males and females from an urban, working population in the Makana (Grahamstown) region of the Eastern Cape, South Africa. Two-hundred and ninety one individuals (males: n = 143, females: n = 148) with a mean age of 42.6 (±8.1) years were voluntarily recruited from the greater urban Makana (Grahamstown) area. Eight Cardiovascular disease (CVD) risks were assessed: stature and mass were obtained in order to calculate body mass index (BMI) (mass/stature2). Obesity, defined as a morphological risk

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Hong, Shu-Jhen, and 洪淑貞. "The effect of Opuntia dillenii fruit on hypercholesteremia rats." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/7w3aaw.

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碩士<br>靜宜大學<br>食品營養研究所<br>97<br>Several researchs pointed out that the cactus fruit (Opuntia dillenii fruit), which contained abundant antioxidants, might lessen the imbalance of oxidative status and complication of chronic disease. The purpose of this study was to examine the effect of Opuntia dillenii fruit (ODF) in hypercholesteremia rats. Four-week-old male Wistar rats were randomly assigned into four experimental groups, inclouding normal control, normal diet with ODF (100mg/Kg BW), high cholesterol diet (2% cholesterol+15% soy oil), high cholesterol diet with ODF (2% cholesterol+15% soy o

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Chou, pey-ue, and 周佩玉. "Effect of Magnolia Officinalis and Nitric Oxide on Baroreflex Function in Hypercholesteremia." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/42924056518104921604.

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碩士<br>中國醫藥大學<br>醫學研究所<br>92<br>Hypercholesterolemia is an important pathogenic factor in atherogenesis. In hypercholesterolemia, nitric oxide (NO) production was enhanced. Over production of NO was found to attenuate baroreflex function. This is consistent with the findings that baroreflex sensitivity (BRS) was depressed in hypercholesterolemia. The Chinese herb, Magnolia officinalis, was shown to improve hypercholesterolemia. However, whether the Magnolia officinalis could also improve BRS is not known. In some pathophysiological states, such as in hemorrhage, BRS was also depressed and could

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Motyka, Patricia A. "Examination of the association between a child's perception of everyday life stressors and elevations in serum cholesterol a report submitted in partial fulfillment ... for the degree of Master of Science, Parent/Child Nursing ... /." 1997. http://catalog.hathitrust.org/api/volumes/oclc/68799490.html.

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Cavanaugh, Juleen Ann. "Molecular genetics of the low density lipoprotein receptor gene." Phd thesis, 1992. http://hdl.handle.net/1885/141064.

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Engelbrecht, Christian. "The efficacy of panax ginseng IX on plasma cholesterol levels of middle aged adults." Thesis, 2009. http://hdl.handle.net/10210/2373.

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M.Tech.<br>It is estimated that 4.5 million South Africans have hypercholesterolaemia. Atherosclerosis and stroke-related conditions have been identified by the South African Department of Health as priority diseases (South African Department of Health, 1998). Hypercholesterolaemia was estimated to have caused 4.6% of all deaths in South Africa in 2000 and is therefore an important cardiovascular risk factor in all population groups in South Africa (Norman et al, 2007). Panax ginseng is the botanical name for the plant commonly known as Korean ginseng. It is part of the Araliaceae botanical fa

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Liao, Wei-Chuan, and 廖偉全. "The role of Chinese herb essences on oxidative DNA damage and repair in the rabbit model of hypercholesteremia." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/96798365726707481953.

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碩士<br>中國醫藥學院<br>醫學研究所<br>91<br>Atherosclerosis is a chronic inflammatory disease. New Zealand White (NZW) rabbits were assigned randomly into six and eleven treated groups. The normal group was fed regular rabbit chow and the cholesterol group was fed a chow containing 0.5% cholesterol. 8-hydroxy-deoxyguanosine (8-OH-dG) is a main index of oxidatively damage DNA. We extracted DNA in the liver tissues and blood vessel of NZW rabbits. Sample analysis was performed using high-performance liquid chromatography /electrochemical detector (HPLC-ECD). These data revealed that 8-OHdG increased signific

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Liebenberg, Tricia. "The lipid-modifying properties of Vasostate™ in males." Thesis, 2014. http://hdl.handle.net/10210/10353.

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M.Tech. (Homoeopathy)<br>South Africa is a diverse and multi-cultured country where coronary vascular disease has become a leading cause of mortality among all sub-cultures. According to the South African Dyslipidaemia Guidelines Consensus Statement published in 2012 it is estimated that every day 80 people die of myocardial infarcts and 60 people die of strokes. Hypercholesterolaemia is associated with the accumulation of atherosclerotic plaques which lead to the condensing and restriction of vessel walls. This in turn leads to an increased risk of developing cardiovascular disease which can

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"Hypocholesterolemic, antioxidative and estrogenic effects of soybean isoflavones." 2003. http://library.cuhk.edu.hk/record=b5896078.

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Lee Chung-hung.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 113-133).<br>Abstracts in English and Chinese.<br>Chapter Chapter 1 --- General Introduction<br>Chapter 1.1 --- History of soybean --- p.1<br>Chapter 1.2 --- Health benefits of soybean --- p.2<br>Chapter 1.3 --- Introduction to flavonoids --- p.3<br>Chapter 1.4 --- Bioavailability of flavonoids --- p.5<br>Chapter 1.5 --- Chemistry of isoflavones --- p.6<br>Chapter 1.6 --- Estrogenic property of isoflavones --- p.8<br>Chapter 1.7 --- Nutritional significance of isofla

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"Hypocholesterolemic activity and potential reproductive toxicity of isoflavones in soybean and gegen." 2005. http://library.cuhk.edu.hk/record=b5892406.

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Guan, Lei.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2005.<br>Includes bibliographical references (leaves 123-145).<br>Abstracts in English and Chinese.<br>ACKNOWLEDGEMENT --- p.I<br>ABSTRACT --- p.II<br>LIST OF ABBREVIATIONS --- p.VII<br>TABLE OF CONTENT --- p.IIX<br>Chapter Chapter 1 --- General Introduction --- p.1<br>Chapter 1.1 --- Introduction --- p.1<br>Chapter 1.2 --- Distribution and Origins --- p.1<br>Chapter 1.3 --- History of Use --- p.2<br>Chapter 1.4 --- Chemical Structure --- p.3<br>Chapter 1.5 --- Physiologic Properties --- p.5<br>Chapter 1.6 --- Absorptio

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"A new strategy to determine whose cholesterol to measure for primary prevention of cardiovascular disease: a modelling study using UK and Chinese data." 2012. http://library.cuhk.edu.hk/record=b5549392.

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目的：針對心血管初級預防，世界各國均推薦某一年齡段人群全部測量膽固醇以估算心血管病發病風險。此舉耗費高且非必須，本研究旨在建立並驗證一個新型的选择性膽固醇篩查模型，用以篩查需藥物治療之高危人群，并在成本效益方面與其它篩查模型相比較。<br>方法：本模型具體采用兩步法：首先利用一個足夠高的假設膽固醇值代入心血管病風險預測方程，用以系統性的高估絶大多數人的心血管病風險；其次只有假設心血管病風險高於推薦治療閾值時，該個體才需要測量膽固醇，並進行實際心血管病風險分析。<br>英国健康调查和中国营养与健康调查是本次研究的合适数据。我們首先探索最優的假設膽固醇值，尋找到最後膽固醇值之後，我們將繼續測試我們的新型膽固醇篩查模型，在不同的治療閾值下，表現是否穩定。我們以靈敏度，特異度和徐篩查人群為指標，比較我們模型與全民篩查模型和英國NICE 選擇篩查模型相比較。之後我們估算在中英人群中應用該篩查模型，所需耗費的成本和可預防心血管事件數。<br>结果：與全名篩查模型相比，我們的模型靈敏度相若但可以節省80%左右的篩查費用。模型的靈敏度主要取決於所採用的假設膽固醇值，與所用風險預測方程，治療閾值和人群心血管風險分佈無關。當以均數加2 倍標準差作為假設膽固醇值時，靈敏度可達到97.5%左右，特異度可以達到90%左右，符合預期。模型應用於中國人群得到的結果類似。值得註意的是，在中國人群中，即使不測量膽固

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"Pharmacogenetic and environmental determinants of response to HMG-CoA reductase inhibitors." Thesis, 2007. http://library.cuhk.edu.hk/record=b6074340.

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A total of 146 Chinese patients with various degrees of hyperlipidaemia and high cardiovascular risk, suitable for treatment with rosuvastatin 10 mg daily and in whom it was possible to obtain baseline lipid profiles measured on no lipid lowering drug, were enrolled in to the study. The drug compliance was assessed by personal interview and 9 patients were excluded from the efficacy analysis because they stated their compliance was less than 80%. From the remaining 137 subjects, 62 had a clinical diagnosis of familial hypercholesterolaemia. Data for dietary intake were available in 121 of the

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Söllner, Tanja. "Analyse von Proteinen und deren Elimination durch drei verschiedene extrakorporale Therapieverfahren der LDL-Apherese bei Patienten mit familiärer Hypercholesterinämie mittels Proteomics-Methoden." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-AFEC-0.

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Owen, Meredith Kohr. "Effect of coronary perivascular adipose tissue on vascular smooth muscle function in metabolic syndrome." Thesis, 2013. http://hdl.handle.net/1805/3789.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Obesity increases cardiovascular disease risk and is associated with factors of the “metabolic syndrome” (MetS), a disorder including hypertension, hypercholesterolemia and/or impaired glucose tolerance. Expanding adipose and subsequent inflammation is implicated in vascular dysfunction in MetS. Perivascular adipose tissue (PVAT) surrounds virtually every artery and is capable of releasing factors that influence vascular reactivity, but the effects of PVAT in the coronary circulation are unknown. Accordingly, the goal of this inves

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