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Rozprawy doktorskie na temat „Hypothalamic-pituitary-adrenal axis”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Evuarherhe, Obaro. "Gender, puberty and the hypothalamic-pituitary-adrenal axis." Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618813.

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The hypothalamo-pituitary-adrenal (HPA) axis, a neuroendocrine pathway involved in the stress response is well studied in both human beings and rodents. Major gender-related neuroendocrine changes take place during pubcl1y (days 30 - 60 in rats) including a robust increase in the levels of gonadal steroids which are thought to underlie numerous neural and behavioural changes brought on after puberty. Evidence suggests the HPA axis undergoes significant changes over the pubertal period. This project investigated the effects of gonadal steroids on the HPA axis before and after puberty and the ro

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Stirrat, Laura Ingram. "Hypothalamic pituitary adrenal axis dysregulation in obese pregnancy." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28979.

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There has been a global rise in obesity in the last three decades, and at present one in five women are obese at antenatal booking. Maternal obesity is associated with an increased risk of adverse pregnancy outcomes, including increased fetal size and prolonged pregnancy. In the longer-term, offspring of obese are at increased risk of premature death from a cardiovascular event in their adulthood. One mechanism that has been linked to these outcomes is fetal exposure to glucocorticoids in utero. During normal pregnancy, the maternal hypothalamic pituitary adrenal (HPA) axis undergoes major cha

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3

Näsman, Birgitta. "The limbic-hypothalamic-pituitary-adrenal axis in Alzheimer's disease." Doctoral thesis, Umeå universitet, Geriatrik, 1994. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140822.

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Dysfunction of the limbic-hypothalamic-pituitary-adrenal (LHPA) axis is a common finding in advanced dementia. In this study, the function of the LHPA axis at different levels was investigated in patients with dementia and in healthy elderly. A subtle disturbance in the feedback regulation of the LHPA axis was found in patients with early (i.e., mild to moderate) Alzheimer’s disease (AD). After 0.5 mg dexamethasone, serum cortisol levels were less suppressed in AD patients and plasma adrenocorticotropin (ACTH) levels were lower as compared with healthy elderly. After stimulation with human cor

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4

Watson, Stuart. "Hypothalamic-pituitary-adrenal axis function in mood disorder patients." Thesis, University of Newcastle upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413260.

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Dembek, Katarzyna Agnieszka. "Hypothalamic-pituitary-adrenal axis dysfunction in critically ill foals." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1479220019340433.

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Gillich, Anton. "The role of histamine in the hypothalamic - pituitary - adrenal axis /." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55496.

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Histamine appears to act as a neurotransmitter within the CNS and may be involved in the regulation of a number of physiological systems including the Hypothalamic-Pituitary-Adrenal (HPA) axis. We conducted a series of experiments in rats to examine the role of histamine within the HPA axis. We first determined if histamine undergoes diurnal variations in the paraventricular nucleus, the periventricular nucleus, and the ventro-medial nucleus of the hypothalamus, the frontal cortex, septal nucleus, median eminence, posterior hypothalamus, mammillary bodies, supraoptic nucleus, suprachiasmatic n

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7

Zollner, Ekkehard Werner Arthur. "Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on corticosteroids." Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95468.

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Thesis (PhD)-- Stellenbosch University, 2013.<br>ENGLISH ABSTRACT: Although the effect of inhaled corticosteroids (ICS) on the hypothalamic- pituitary-adrenal axis (HPA) has been regarded as a “benign physiological response”, a survey published in 2002 suggested that adrenal crisis is more common in asthmatic children on ICS than previously thought. Relying on clinical features to detect chronic adrenal insufficiency secondary to corticosteroids may not be wise, as these are non-specific and can therefore easily be missed. Accurate biochemical assessment of the whole axis to detect subcli

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8

Kalyani, Manu. "Interaction between Prolactin and the Hypothalamic-Pituitary-Adrenal (HPA) axis." Miami University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=miami1397233916.

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9

Reynolds, Rebecca M. "Programming of the hypothalamic-pituitary-adrenal axis during fetal life." Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23168.

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The aim of this thesis was to study the HPA axis in detail, examining aspects of both activity of the axis and cortisol action, in order to determine variations that could explain the link between low birthweight and subsequent development of cardiovascular risk factors. The principal findings were that men aged 66-77 years, who were of low birthweight and/or with the Metabolic Syndrome, have activation of the HPA axis with increased cortisol response to ACTH<sub>1-24</sub> and increased urinary cortisol metabolite excretion. In contrast to rats programmed by dexamethasone administration durin

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10

Heinzmann, Jan-Michael. "Central and peripheral aspects of hypothalamic-pituitary-adrenal (HPA) axis dysfunction." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-150032.

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Sudlow, Allan William. "Actions of lipocortin-1 on the immune-hypothalamic-pituitary-adrenal axis." Thesis, University of Manchester, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618752.

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It is thought that the involvement of common mediators such as corticotrophin releasing hormone (CRR), cytokines, prostaglandins (PG's), pituitary peptides and glucocorticoids allows the integration of immune and neuroendocrine activity during the acute phase response (APR) to injury and infection. Glucocorticoids are the major inhibitory component within this complex system, which has been termed the immunehypothalamic- pituitary-adrenal (HPA) axis. In the past, lipocortin-1 (LC-1) has been implicated as a "second messenger" of glucocorticoid actions. The present study explored this potential

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12

Connan, Frances. "An investigation of hypothalamic pituitary adrenal axis hyperactivity in anorexia nervosa." Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419238.

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13

Hesketh, Shirley Anne. "Pharmacological manipulation of central serotonin and the hypothalamic-pituitary-adrenal axis." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404294.

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Porter, Richard J. "Corticosteroid serotonin interactions in depression." Thesis, University of Newcastle upon Tyne, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289200.

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Buss, Nicholas Alexander Piers Sascha. "The role of formyl peptide receptors within the hypothalamic pituitary adrenal axis." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5849.

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Annexin 1 (ANXA1) is an important mediator of the regulatory effects of glucocorticoids (GCs) within the neuroendocrine and host defence systems. Recent data suggest that it acts via a formyl peptide receptor (FPR) as a mediator of the negative feedback effects of GCs on adrenocorticotrophic hormone (ACTH) release. In the present study, in vitro and in vivo methods were used to detect and explore further the function of these receptors within the hypothalamo-pituitary-adrenocortical (HPA) axis. Lipopolysaccharide (LPS), given intra-peritoneally (i.p.) or centrally (i.c.v.), increased expressio

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16

Symonds, Catherine. "The hypothalamic-pituitary-adrenal axis in depression : a focus on the hippocampus." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/the-hypothalamic--pituitary--adrenal-axis-in-depression-a-focus-on-the-hippocampus(65f9eca0-f831-4bf0-a934-0f3d21b8856c).html.

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Background: The hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the aetiopathology of depression, and the incidence of HPA dysfunction tends to increase with the severity of treatment resistance. In healthy volunteers (HV), both acute and chronic hypercortisolaemia causes cognitive impairment, including emotional memory. The exact mechanism of this remains unclear; however the action of cortisol on corticosteroid receptors in the hippocampus appears to be crucial and this may also be important in the aetiopathology of depression. The aim of this thesis was to investigate acute

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17

Bakirtzi, Georgia. "Epigenetic regulation of POMC : implications for the hypothalamic-pituitary-adrenal (HPA) axis." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/9455/.

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18

Crane, James William. "Limbic system control of endocrine stress responses /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16769.pdf.

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19

Beck, Meredith Nell. "Effects of Prolactin on the Hypothalamic Pituitary Adrenal Axis in Postpartum Female Rats." Miami University Honors Theses / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1303497697.

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Nye, Elisabeth Jane. "Dynamic stimulation tests in the assessment of hypothalamic-pituitary-adrenal axis function in pituitary disease and obesity /." St. Lucia, Qld, 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17166.pdf.

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21

Janse, van Vuuren Marthinus. "Hypothalamic-pituitary-adrenal-axis vs. the sympatho-adrenal medullary system in the acute response to psychological stress." Thesis, Stellenbosch : University of Stellenbosch, 2011. http://hdl.handle.net/10019.1/6738.

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Thesis (MSc (Physiological Sciences))--University of Stellenbosch, 2011.<br>Includes bibliography.<br>ENGLISH ABSTRACT: The hypothalamic-pituitary-adrenal-(HPA) axis has long been closely associated with psychological stress-induced activation of the adrenal cortex and subsequent glucocorticoid production. Another, less known peripheral limb of the psychological stress response, is the sympatho adrenal medullary pathway. We hypothesized that the sympatho-adrenal medullary system constitutes the primary response to acute psychological stress, with the HPA-axis functioning as a secondary re

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22

Dumbell, Rebecca. "The role of the hypothalamic-pituitary-growth axis in the regulation of seasonal and exercise induced weight gain in the Siberian hamster." Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid+214824.

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The Siberian hamster (Phodopus sungorus) undergoes a suite of physiological changes in response to short day (SD) photoperiod which includes a marked reduction in body mass (up to 40%). This altered physiology can be reversed by a return to long day (LD) photoperiod and is driven by changes hypothalamic gene expression. Additionally, stimulation of weight regain occurs through spontaneous exercise when hamsters are provided with a running wheel (RW), despite intact photoperiod appropriate hypothalamic gene expression. The foundation hypothesis for this investigation was that the change in body

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23

Bruner, Natalie R. "Effects of prenatal stress on lever-press acquisition, delay discounting, and ethanol self-administration in rats." Morgantown, W. Va. : [West Virginia University Libraries], 2010. http://hdl.handle.net/10450/10882.

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Thesis (Ph. D.)--West Virginia University, 2010.<br>Title from document title page. Document formatted into pages; contains vi, 67 p. : ill. Includes abstract. Includes bibliographical references (p. 59-67).

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Jeffray, Treena. "The effects of cortisol on the development of the fetal hypothalamic-pituitary-adrenal axis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ41180.pdf.

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Tannenbaum, Beth. "Hypothalamic-pituitary-adrenal axis regulation over the lifespan : contribution of dietary and lifestyle factors." Thesis, McGill University, 2000. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=36842.

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A delicate balance exists between the protective effects of adrenal glucocorticoids (GCs) secreted in response to stress and the negative consequences that the excessive production of these hormones may have for numerous systems. GCs are involved in the regulation of the stress response, have effects on feeding and body weight gain and are associated with the acceleration of central nervous system aging. Their production, secretion, and containment are subject to both environmental modulation and individual variation. Neonatal manipulations known to affect the development of the adult hypothal

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26

Hawkins, Paul. "Nutritional influences on development of the cardiovascular system and the hypothalamic-pituitary-adrenal axis." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325124.

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Faghih, Rose Taj. "The FitzHugh-Nagumo model dynamics with an application to the hypothalamic pituitary adrenal axis." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/60161.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.<br>Includes bibliographical references (p. 68-70).<br>In this thesis, I revisit the issue of the utility of the FitzHugh-Nagumo (FHN) model for capturing neuron firing behaviors. It has been noted (e.g., see [8]) that the FHN model cannot exhibit certain interesting firing behaviors such as bursting. I will illustrate that, by allowing time-varying parameters for the FHN model, one could overcome such limitations while still retaining the low order complexity of the FHN model. I al

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Cullen, Alexis Elizabeth. "Increased stress susceptibility and hypothalamic-pituitary-adrenal axis dysfunction : early markers of psychosis vulnerability?" Thesis, King's College London (University of London), 2014. http://kclpure.kcl.ac.uk/portal/en/theses/increased-stress-susceptibility-and-hypothalamicpituitaryadrenal-axis-dysfunction(b602f1f0-1006-4491-a112-83d5156f8e13).html.

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Background: Individuals with psychosis are characterised by increased exposure and reactivity to psychosocial stressors and abnormal hypothalamic-pituitary-adrenal (HPA) axis function [i.e., elevated cortisol levels, a blunted cortisol awakening response (CAR), and pituitary volume abnormalities]. The extent to which these features are present among at-risk individuals, prior to illness onset, is currently unclear. Aims: To determine whether putatively at-risk children who present multiple antecedents of schizophrenia (ASz) or a family history of illness (FHx) show increased susceptibility to

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Steele, Amber. "Cortisol and mood as a function of luteal progesterone change : a prospective cohort study in Cambridge using diary methods and biological samples." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610359.

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Dettmer, Amanda M. "Early rearing experience, hypothalamic-pituitary-adrenal (HPA) activity, and serotonin transporter genotype influences on the development of anxiety in infant rhesus monkeys (Macaca mulatta) /." Amherst, Mass. : University of Massachusetts Amherst, 2009. http://scholarworks.umass.edu/open_access_dissertations/45/.

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Williamson, Martin Alexander. "Unmasking the functional anatomy of medial preoptic nucleus-influences on the hypothalamic-pituitary-adrenal axis." Thesis, University of British Columbia, 2009. http://hdl.handle.net/2429/7628.

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The hypothalamic-pituitary-adrenal (HPA) axis is a critical mediator of the stress response system. However, despite clear evidence for an inhibitory role of testosterone on stress-induced activation of the HPA axis, the routes and mechanisms have not been addressed. To first determine where testosterone acts in the brain to regulate stress-related input to the HPA axis, I used a combined retrograde transport and immunohistochemical procedure to characterize the anatomical nature by which androgen targets in the brain communicate with the paraventricular nucleus (PVN) of the hypothalamus

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Dembek, Katarzyna Agnieszka. "Renin-Angiotensin-Aldosterone System (RAAS) and Hypothalamic-Pituitary-Adrenal Axis (HPAA) in Critically Ill Foals." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337797078.

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Pyter, Leah M. "Seasonal plasticity of physiological systems, brain, and behavior." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1141319505.

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Bingham, Brenda. "Role of neonatal testosterone in shaping the adult male hypothalamic-pituitary-adrenal axis response to stress." Thesis, University of British Columbia, 2012. http://hdl.handle.net/2429/40838.

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Testosterone exposure during critical periods of development exerts major organizing effects on the hypothalamic-pituitary-adrenal (HPA) axis. The aim of this thesis was to determine how HPA axis activity is altered by neonatal testosterone, and where and how this might occur in the adult brain. In chapter two, I demonstrate that neonatal gonadectomy increased plasma corticosterone and Fos activation in the ACTH-regulating zone of the paraventricular nucleus of the hypothalamus under basal conditions and following restraint exposure. These responses were normalized with postnatal, but not ad

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Schmidt, Kristin. "Manipulating the hypothalamic-pituitary-adrenal axis : effects on cognitive and emotional information processing and neural connectivity." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:c0475a98-e070-4446-9179-eb87047cb854.

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Despite extensive evidence documenting abnormal hypothalamic-pituitary-adrenal (HPA) axis functioning as a risk factor for the development of depression and other psychiatric disorders, and experimental evidence from acute stress manipulations, the effects of sustained cortisol alterations on clinically relevant cognitive-behavioural and neural processing remain poorly understood. The aim of this thesis was to characterise how non-acute changes in cortisol levels modify behavioural and neural biases implicated in stress-related disorders by following two complementary lines of evidence: firstl

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Farag, Noha Hassan. "Effect of physical activity on hypothalamic-pituitary-adrenal axis functioning in a multiracial sample of adolescents." Oklahoma City : [s.n.], 2009.

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Barugh, Amanda Jayne. "Delirium and long-term cognitive impairment after stroke : the role of the hypothalamic-pituitary-adrenal axis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/28800.

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Delirium is a severe neuropsychiatric syndrome, characterised by the acute onset of inattention, altered level of arousal, and other mental status abnormalities. Delirium is extremely common in acute stroke, affecting at least 1 in 5 such patients admitted to hospital. It is a serious complication of stroke, being associated with higher mortality, longer length of hospital stay and higher dependency at discharge. The pathophysiology of delirium is not completely understood, and there are no specific treatments. This thesis investigated the role of cortisol in the development of delirium after

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Barnum, Christopher John. "Repeated exposure to restraint but not social defeat leads to habituation of the pituitary-adrenal and stress-herthermic responses." Diss., Online access via UMI:, 2006.

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Coleman, Georgia. "Effects of postnatal light environment on the development of the mouse stress system." Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/effects-of-postnatal-light-environment-on-the-development-of-the-mouse-stress-system(1cb0bdca-3aaa-4d92-879c-98131575aff2).html.

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The postnatal period is a critical time for development where external influences can help shape the long-term structure and function of the brain. Adverse experiences or stressors during the postnatal period, such as abuse or neglect, can have huge consequences on the long term function, health and susceptibility to disease. One environmental factor, whose importance is becoming increasingly more recognised for normal development, is light. Abnormal light during the first three weeks of life has been shown to have long term effects on the circadian system of rodents. On the other hand, the ef

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Daniel, Joseph A. "Comparison of caesarian section and vaginal birth in pigs /." free to MU campus, to others for purchase, 1999. http://wwwlib.umi.com/cr/mo/fullcit?p9962516.

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Edwards, Lisa J. "Maternal undernutrition and fetal blood pressure and the hypothalamo-pituitary adrenal axis in the late gestation fetal sheep." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phe2654.pdf.

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Includes bibliographical references (leaves 228-257). Aims to determine the impact of maternal undernutrition during late gestation and during the periconceptional and gestational periods on fetal growth, fetal blood pressure and the fetal hypothalamo-pituitary adrenal axis in the sheep.

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Khalili-Mahani, Najmeh 1971. "Observing the stressed brain : magnetic resonance imaging of the neural correlates of hypothalamic pituitary adrenal axis function." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115857.

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The Hypothalamic Pituitary Adrenal (HPA) axis is the coordinator of adaptive responses to physical and psychological stress. The central nervous system plays a key role in modulation of both basal and adaptive HPA axis functions. In fact, since long ago, animal studies have shown that acute and chronic exposure to glucocorticoids (a stress hormone released due to HPA axis activation, cortisol in humans) affects the function and the morphology of brain areas such as the hippocampus and the cingulate cortex. This thesis is based on novel neuroimaging methodologies used to investigate the interac

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Abebe, Getachew. "The integrity of the hypothalamic-pituitary-adrenal axis in Boran (Bos indicus) cattle infected with Trypanosoma congolense." Thesis, Brunel University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292991.

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Ward, Alexandra Monica Vivienne. "Fetal programming of the hypothalamic-pituitary-adrenal axis : is cortisol production upregulated centrally in low birthweight individuals?" Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400535.

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Grundy, Paul L. "The hypothalamic-pituitary-adrenal axis and hippocampal neutrophin responses to traumatic brain injury in relation to outcome." Thesis, University of Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399894.

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Osborne, Sarah Ann. "Antenatal depression and developmental programming of offspring hypothalamic-pituitary-adrenal axis in the first year of life." Thesis, King's College London (University of London), 2016. https://kclpure.kcl.ac.uk/portal/en/theses/antenatal-depression-and-developmental-programming-of-offspring-hypothalamicpituitary(22ef00fa-ac36-48c6-a79f-0197ea03723d).html.

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Background: Research in humans demonstrates a link between an adverse environment during development and unfavourable health outcomes in adulthood. Animal research used to understand this phenomenon reveals that exposure to prenatal stress and to glucocorticoids may programme offspring hypothalamic-pituitary-adrenal (HPA) axis, which is in turn hypothesised to mediate disease risk. Extension of these findings in human research is at a less advanced stage, although synthesis of a number of lines of evidence suggests that similar HPA axis programming exists. Glucocorticoids are hypothesised as t

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Warner, Judith Catherine. "Biology and Environment, Mothers and Infants: Linking Stress Physiology, Depression, Anxiety and Attachment." Thesis, Griffith University, 2013. http://hdl.handle.net/10072/365334.

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The last two decades have seen research on early life experiences expand to include the prenatal environment and, more specifically, examination of the effects of prenatal maternal mental health on foetal and infant development. Cortisol, the hormonal end product of the Hypothalamic Pituitary Adrenal (HPA) Axis, has been identified as one mechanism associated independently with stress, pregnancy and mental health, which can account for changes during foetal development. In the postpartum, these early life experiences may serve as protective or risk factors for the infant. The longitudinal stud

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Spencer, Sarah J. "Stress and the brain : role of the medial prefrontal cortex in regulation of the hypothalamic-pituitary-adrenal axis /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18148.pdf.

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Larivière, William R. "The role of the hypothalamic-pituitary-adrenal axis in the susceptibility to adjuvant-induced polyarthritis in the rat." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ64597.pdf.

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Oates, Maxwell. "The role of leptin during neonatal rat development : impact on the hypothalamic-pituitary-adrenal axis and energy balance." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0032/MQ64419.pdf.

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