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Artykuły w czasopismach na temat "I-Motifs"

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Shamim, Amen, Maria Razzaq, and Kyeong Kyu Kim. "MD-TSPC4: Computational Method for Predicting the Thermal Stability of I-Motif." International Journal of Molecular Sciences 22, no. 1 (2020): 61. http://dx.doi.org/10.3390/ijms22010061.

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I-Motif is a tetrameric cytosine-rich DNA structure with hemi-protonated cytosine: cytosine base pairs. Recent evidence showed that i-motif structures in human cells play regulatory roles in the genome. Therefore, characterization of novel i-motifs and investigation of their functional implication are urgently needed for comprehensive understanding of their roles in gene regulation. However, considering the complications of experimental investigation of i-motifs and the large number of putative i-motifs in the genome, development of an in silico tool for the characterization of i-motifs in the
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Teklasani, Juita, and Luh Putu Tejawati Ni. "MAKNA FILOSOFI MOTIF KAIN TENUN SONGKE DI DESA PONNG LENGOR KECAMATAN RAHONG UTARA KABUPATEN MANGGARAI NUSA TENGGARA TIMUR." Widyadari 23, no. 2 (2022): 389–99. https://doi.org/10.5281/zenodo.7190282.

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<em>This study aims to determine (1) the forms of Songke Manggarai woven fabric motifs; (2) Factors influencing the development of Songke Manggarai woven fabric motifs; (3) The philosophical meaning of Songke woven fabric motifs. The theory used in this research is symbol theory, consumer culture theory and semiotic theory. In an effort to obtain data, the method of determining informants, data collection methods, and data processing methods is used. This study concludes that (1) the Songke Manggarai woven motifs include the wela runu motif, the ranggong motif, the wela kaweng motif, the ntala
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Catur, Edi Widodo. "THE USE OF FRACTAL GEOMETRY IN TILING MOTIF DESIGN." International Journal of Innovative Research in Advanced Engineering VII, no. Iv (2020): 263–66. https://doi.org/10.26562/ijirae.2020.v0704.001.

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In this paper I will present the use of fractal geometry to design tile motifs. A fractal is a geometric figure that combines the several characteristics among others: its parts have the same form as the whole, fragmented, and formation by iteration. The concept of fractals has been spread over all fields of sciences, technology, and art. This paper aims to provide an algorithm to creating motifs of tile algorithm for create the tile motif consists of base, iteration, coloration and duplication. In order to help the reader better understand the algorithm, I will present some script using Matla
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Jiang, Guimei, Lijun Xu, Kewei Wang, et al. "Quinaldine red as a fluorescent light-up probe for i-motif structures." Analytical Methods 9, no. 10 (2017): 1585–88. http://dx.doi.org/10.1039/c7ay00301c.

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We report a new fluorescent probe for i-motif structures. When binding to i-motifs, quinaldine red exhibits a remarkable increase in its fluorescence, which benefits i-motif-involved label-free systems.
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Ruggiero, Emanuela, Sara Lago, Primož Šket, et al. "A dynamic i-motif with a duplex stem-loop in the long terminal repeat promoter of the HIV-1 proviral genome modulates viral transcription." Nucleic Acids Research 47, no. 21 (2019): 11057–68. http://dx.doi.org/10.1093/nar/gkz937.

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Abstract I-motifs are non-canonical nucleic acids structures characterized by intercalated H-bonds between hemi-protonated cytosines. Evidence on the involvement of i-motif structures in the regulation of cellular processes in human cells has been consistently growing in the recent years. However, i-motifs within non-human genomes have never been investigated. Here, we report the characterization of i-motifs within the long terminal repeat (LTR) promoter of the HIV-1 proviral genome. Biophysical and biochemical analysis revealed formation of a predominant i-motif with an unprecedented loop com
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Martins, Alexandra, Christian H. Gross, and Stewart Shuman. "Mutational Analysis of Vaccinia Virus Nucleoside Triphosphate Phosphohydrolase I, a DNA-Dependent ATPase of the DExH Box Family." Journal of Virology 73, no. 2 (1999): 1302–8. http://dx.doi.org/10.1128/jvi.73.2.1302-1308.1999.

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ABSTRACT Vaccinia virus nucleoside triphosphate phosphohydrolase I (NPH-I) is a DNA-dependent ATPase that serves as a transcription termination factor during viral mRNA synthesis. NPH-I is a member of the DExH box family of nucleic acid-dependent nucleoside triphosphatases (NTPases), which is defined by the presence of several conserved sequence motifs. We have assessed the contributions of individual amino acids (underlined) in motifs I (GxGKT), II (DExHN), III (SAT), and VI (QxxGRxxR) to ATP hydrolysis by performing alanine scanning mutagenesis. Significant decrements in ATPase activity resu
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Nufer, Oliver, Svend Guldbrandsen, Martin Degen, et al. "Role of cytoplasmic C-terminal amino acids of membrane proteins in ER export." Journal of Cell Science 115, no. 3 (2002): 619–28. http://dx.doi.org/10.1242/jcs.115.3.619.

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Export of membrane proteins from the ER is believed to be selective and require transport signals, but the identity of such signals has remained elusive. The recycling type I membrane protein ERGIC-53 carries a C-terminal diphenylalanine motif that is required for efficient ER export. Here we show that this motif can be functionally substituted by a single phenylalanine or tyrosine at position -2, two leucines or isoleucines at position -1 and -2 or a single valine at position -1. These motifs are common among mammalian type I membrane proteins. A single C-terminal valine, but none of the othe
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Saha, Puja, Deepanjan Panda, Diana Müller, Arunabha Maity, Harald Schwalbe, and Jyotirmayee Dash. "In situ formation of transcriptional modulators using non-canonical DNA i-motifs." Chemical Science 11, no. 8 (2020): 2058–67. http://dx.doi.org/10.1039/d0sc00514b.

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Grote, Johanna, Beate Neumann, Hans-Georg Stammler, and Norbert W. Mitzel. "Diversity of aggregation motifs in gold(i) dithiocarboxylate complexes." Dalton Transactions 47, no. 13 (2018): 4701–6. http://dx.doi.org/10.1039/c8dt00342d.

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Molecular structures and aggregation motifs of different substituted gold(i) dithiocarboxylate complexes are presented and a correlation between the substituent and the aggregation motif is discussed.
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Grote, Johanna, Beate Neumann, Hans-Georg Stammler, and Norbert W. Mitzel. "Silver(i) dithiocarboxylate complexes – clustering and aggregation." Dalton Transactions 47, no. 17 (2018): 6036–40. http://dx.doi.org/10.1039/c8dt00279g.

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Molecular structures and aggregation motifs of a series of neutral homoleptic silver(i) dithiocarboxylate are presented and a correlation between the substituent and aggregation motif as well as the differences from the (almost) analogous gold(i) complexes are discussed.
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Rozprawy doktorskie na temat "I-Motifs"

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Gurung, Sarah Prava. "Biophysical & crystallographic studies of DNA i-motifs." Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/77642/.

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Intramolecular i-motifs of the form C3L3-8C3L3-8C3L3-8C3, where C3 denotes the cytosine stretch and L3-8 are “loop” regions containing any DNA base (L) including cytosine, were studied to understand the effects of loop length on i-motif stability. It contrast to the previously held notion that long-looped i-motifs are more stable, it was found that i-motif structures with short loops exhibit higher thermal stabilities and transitional pH values. The stability of long-looped i-motifs are then shown to increase with the addition of [Ru(phen)2dppz]2+ (phen = 1,10-phenanthroline, dppz = dipyrido [
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Mir, Morro Bartomeu. "Studies on the formation of i-motif structures at neutral pH. Use of cytidine analogues and importance of minor groove tetrads on mini i-motifs stabilization." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/668126.

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Given the increasing interest in i-motif structures, obtaining such structures as well as detailed structural information under physiological conditions have become hot topics in the structural biology field. In this context, the main objectives of this thesis are focused on the design and detailed characterization of several oligonucleotide sequences that may form stable i-motif structures at neutral pH. The starting point is the mini i-motif structure, extensively studied in the research group that exhibits unusual high pH and thermal stability. These are dimeric structures stabilized by the
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Boissieras, Joseph. "Étude des interactions de ligands et d'anticorps avec les i-motifs de l'ADN." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF080.

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Les i-motifs sont des structures tétramériques d'ADN constituées de paires de bases CH+:C intercalées et qui peuvent se former dans des séquences d'ADN riches en cytosine, notamment dans les conditions légèrement acides (pH≈6,0) où certaines cytosines seront protonées. Bien qu'elles soient connues depuis plus de 30 ans, du fait de leur forte dépendance au pH ces structures ont longuement été considérées comme uniquement présentes in vitro. Plus récemment, en 2018, un anticorps iMab a été développé pour cibler les i-motifs et les études ont suggéré leur présence au niveau cellulaire. De nombreu
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Sharma, Amit. "The In Vitro Interactions Between Tubulin and HIV-1 Rev Require Rev’s Multimerization and Arginine-Rich Motifs." Wright State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=wright1261408567.

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Collin, Delphine. "Etudes par methodes spectroscopiques de complexes d'oligonucleotides (motifs-i et interaction boucle-boucle) (doctorat : pharmacochimie)." Paris 11, 1999. http://www.theses.fr/1999PA114835.

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Salisbury, Richard L. Jr. "TCDD represses 3'IghRR activation through an AhR-dependent shift in the NF-κB/Rel protein complexes binding to κB motifs within the hs1,2 and hs4 enhancers". Wright State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=wright1401136335.

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Rais, Nabila. "Représentation de la pensée politique italienne à la croisée du dix-neuvième et vingtième siècle : Lire "I Viceré" de De Roberto et "I vecchi e i giovani" de Pirandello à la lumière du "Prince" de Machiavel." Grenoble 3, 2007. http://www.theses.fr/2007GRE39012.

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Cette thèse a pour thème la représentation de la pensée politique italienne à travers la lecture de deux romans situés à la croisée du 19e et 20e siècle. L'objectif de notre recherche est de lire ces deux romans historiques à la lumière d'une pensée politique révolutionnaire celle de Nicolas Machiavel. Après avoir tenté de cerner les particularités du secrétaire florentin, exposé ses idées révolutionnaires et la spécificité de sa pensée, cette étude se poursuit avec un double objectif. Le premier est l'élaboration d'une approche analytique des deux romans : "I Viceré" de Federico De Roberto et
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Sanchez, David Raul Yusef. "Identification of the viral RNA ligands and host protein partners of the Rig-I Like Receptors in an active infection by viruses of positive and negative polarity." Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCC262.

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Les infections virales peuvent avoir des conséquences dévastatrices pour l'hôte et doivent donc être contrôlés rapidement et efficacement par l'immunité innée antivirale. Les récepteurs de type Rig-I-like (RLR: Rig-I, MDA5 et LGP2) sont en première ligne de la course de l'évolution entre les virus et le système immunitaire de l'hôte. Ils jouent un rôle majeur dans la détection des infections par les virus à ARN pour initier et moduler l'immunité antivirale. Lors de la liaison de l'ARN, les RLR déclenchent une cascade de signalisation en aval résultant dans l'expression des interférons de type
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D'Amours, Benoît. "Retourner la bêche : les fonctions de l'autobiographie dans l'œuvre de Stanley Cavell." Doctoral thesis, Université Laval, 2021. http://hdl.handle.net/20.500.11794/69493.

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Mon objectif ici sera de montrer que Cavell fait de l’autobiographie un exercice d’investigation philosophique. Afin d’atteindre ce but, j’emprunte une approche chronologique. Analysant une par une ses publications les plus importantes, je démontre que l’autobiographie remplit cinq fonctions distinctes dans son œuvre à savoir, une fonction descriptive, une fonction anthropologique, une fonction révisionniste, une fonction morale et une fonction perfectionniste. Ensuite, j’analyse le rapport entre le perfectionnisme moral et le récit autobiographie de Cavell intitulé Si j’avais su. Ma thèse tro
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Bergmann, Tobias [Verfasser]. "Determination of quantitative peptide-binding motifs of four common equine MHC class I alleles, and identification of an equine herpesvirus type 1-derived cytotoxic T lymphocyte epitope / Tobias Bergmann." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1126505285/34.

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Książki na temat "I-Motifs"

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Martin, Jean-Pierre. Les Motifs dans la chanson de geste: Définition et utilisation (discours de l'épopée médiévale,I). Centre d'études médiévales et dialectales, Université de Lille III, 1992.

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Slade, Iris. Između srca i želuca: Neki primjeri animalistike u splitskoj likovnoj umjetnosti = Between heart and stomach : animalistic motifs in Split's visual arts. Galerija umjetnina, 2020.

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Karlsson, Olof. Transcriptional regulation of the rat insulin I gene: Identification of Cis-acting motifs and cloning of an islet-specific homeobox-containing gene. University of Umeaa, 1990.

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Peshekhonova, Larisa. Suprematicheskoe predvidenie: Kosmos v ukrashenii︠a︡kh i grafike Nadi Lezhe = Suprematism vision : Space Motifs in the Graphic Works and Jewelry Designs of Nadia Léger. Gosudarstvennyĭ istoriko-kulʹturnyĭ muzeĭ zapovednik "Moskovskiĭ Kremlʹ", 2021.

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Krajewska, Monika. W papierze i kamieniu: Motywy symboliki żydowskiej w wycinankach i rysunkach Moniki Krajewskiej : luty-marzec 2000, Państwowe Muzeum Etnograficzne w Warszawie = In paper and in stone : Jewish symbolic motifs in papercuts and tombstone rubbings / by Monika Krajewska. Państwowe Muzeum Etnograficzne w Warszawie, 2000.

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Lavlinskiĭ, S. P., та Viktorii︠a︡ Malkina. Grotesknoe i fantasticheskoe v kulʹture: Vizualʹnye aspekty: sbornik stateĭ. Izdatelʹskie reshenii︠a︡, 2017.

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Peer-Brie, Jérémie, and Martin Voyer. Utopies, fictions et satires politiques I: Cycle de conférences 2017. Presses de l'Université Laval, 2018.

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Viktor, Bondarenko, Malʹt︠s︡eva Evgenii︠a︡, Popov Sergeĭ та Galerei︠a︡ Gelʹmana, ред. Dukhovnai︠a︡ branʹ: Proekt Viktora Bondarenko i Evgenii Malʹt︠s︡evoĭ : borʹba za novui︠u︡ zhiznʹ v iskusstve sakralʹnykh obrazov khristianstva : rasshirennyĭ katalog proekta, predstavlennogo v Galeree Marata Gelʹmana v T︠S︡entre sovremennogo iskusstva "Vinzavod". Rossii︠a︡ dli︠a︡ vsekh, 2012.

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ʻAlī, Maḥmūdiyān, та Gūshah Fāṭimah, ред. Yak khānah dar naqsh: Pizhūhishī dar ārāyahʹhā-yi miʻmārī-i Qalʻah-i Chālishtar, mutiʻalliq bih dawrah-i Qājār (ḥajjārrīʹhā-yi naqshpardāzānah va naqqāshīʹhā-yi dīvarī-i khānahʹhā-yi Aḥmad Khān va Maḥmūd Khān) bā taʼkīd bar gūnahʹshināsī-i nuqūsh, mustanadʹsāzī, tadvīn-i sābiqah va shināsnāmah-i naqshʹhā = House in motif. Guldastah, 2014.

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Pool, Daniel. What Jane Austen ate and Charles Dickens knew: Fascinating facts of daily life in the nineteenth century. Robinson, 1998.

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Części książek na temat "I-Motifs"

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Trautwein, Nico, and Stefan Stevanović. "Establishing MHC Class I Peptide Motifs." In Antigen Processing. Humana Press, 2012. http://dx.doi.org/10.1007/978-1-62703-218-6_13.

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Naegeli, Hanspeter. "Molecular Recognition Strategies I: One Enzyme-One Substrate Motifs." In Mechanisms of DNA Damage Recognition in Mammalian Cells. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-6468-9_4.

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Bhavsar-Jog, Yogini P., Samantha M. Reilly, and Randy M. Wadkins. "DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics." In Chemical Biology of Nucleic Acids. Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54452-1_24.

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Ghosh, Michael, Moreno Di Marco, and Stefan Stevanović. "Identification of MHC Ligands and Establishing MHC Class I Peptide Motifs." In Antigen Processing. Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9450-2_11.

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Stead, Evanghelia. "2. A Foetal Laboratory and Its Influence." In Grotesque and Performance in the Art of Aubrey Beardsley. Open Book Publishers, 2024. http://dx.doi.org/10.11647/obp.0413.02.

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Chapter 2, A Foetal Laboratory and Its Influence, studies the foetus motif in Beardsley’s oeuvre from its earliest provocative advent in Incipit Vita Nova (1892) and among the Bon-Mots vignettes up to the untimely end of his career. I grant primacy not to biographical detail (as usual in prior scholarship) but to the motif’s creative and cultural bearings, and its challenging manifesto-like value as portrait of a generation. The chapter shows the foetus’s symbolic meaning for the decadent post-Darwinian zeitgeist and stresses its role as a plastic and morphing stimulus with immediate effect on
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Jacob Ramalho, Joana. "Conclusion: Routes of Re-membering." In Palgrave Gothic. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-73628-5_9.

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AbstractThe cinematic gothic aesthetic, as I have described it in these pages, is an aesthetics of memory, accented in its transcultural authorial roots and displaced characters. The accented style of the films responds to the directors’ socio-cultural condition of displacement, inscribing into the mise-en-scène, atmosphere, and plotlines experiences of dislocation, trespassing, claustrophobia, unbelonging, loss, change, and motifs of itinerancy. In their paralleling of life and art, the films become visual archives of mourning: cinematic representations of personal memory sifted through the r
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Wegener, Anne-Marie K., and Bernard Malissen. "Analysis of the (YXXL/I)2 Signalling Motifs Found in the Cytoplasmic Segment of the Mouse CD3-ζ Chain." In Advances in Experimental Medicine and Biology. Springer US, 1994. http://dx.doi.org/10.1007/978-1-4899-0987-9_5.

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Ashwin-Siejkowski, Piotr. "Reception of the Johannine Motifs in Heracleon's Commentary on the Gospel of John and the Tripartite Tractate, NHC, I, 5." In Valentinus' Legacy and Polyphony of Voices. Routledge, 2021. http://dx.doi.org/10.4324/9781003181095-7.

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Waller, Zoë A. E. "i-Motif Nucleic Acids." In Handbook of Chemical Biology of Nucleic Acids. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-9776-1_97.

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Waller, Zoë A. E. "i-Motif Nucleic Acids." In Handbook of Chemical Biology of Nucleic Acids. Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-16-1313-5_97-1.

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Streszczenia konferencji na temat "I-Motifs"

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Zhao, Jingjing, Jianfang Zhu, Zhengfang Qian, and Shuting Fan. "Application of DNA i-Motifs based Nanobiotechnology for THz biosensing and imaging." In 2024 49th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz). IEEE, 2024. http://dx.doi.org/10.1109/irmmw-thz60956.2024.10697542.

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Udovičić, Bojana B. "MOTIV PRIJATELjSTVA U ROMANIMA „MALI PRINC“ ANTOANA DE SENT-EGZIPERIJA I „AGI I EMA“ IGORA KOLAROVA." In KNjIŽEVNOST ZA DECU U NAUCI I NASTAVI. University of Kragujevac, Faculty of Education in Jagodina, 2022. http://dx.doi.org/10.46793/kdnn21.127u.

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By using a comparative analysis, the paper discusses the similarity of motifs in two novels – a classic of children’s literature, Exypery’s The Little Prince, and Agi i Ema, a contemporary Serbian novel for children. In both novels, extraordinary friendship between characters develops as a result of children’s loneliness and detachment. The characters and the adventures belong both to the real and the unreal world, which is the essence of fiction.
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SAVOIE, C. J., N. KAMIKAWAJI, T. SASAZUKI, and S. KUHARA. "Use of BONSAI decision trees for the identification of potential MHC Class I peptide epitope motifs." In Proceedings of the Pacific Symposium. WORLD SCIENTIFIC, 1998. http://dx.doi.org/10.1142/9789814447300_0018.

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Hu, Weipeng, Si Qiu, Youping Li, Geng Liu, Xiuqing Zhang, and Leo J. Lee. "Abstract 3383: EPIC: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.am2019-3383.

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Hu, Weipeng, Si Qiu, Youping Li, Geng Liu, Xiuqing Zhang, and Leo J. Lee. "Abstract 3383: EPIC: MHC-I epitope prediction integrating mass spectrometry derived motifs and tissue-specific expression profiles." In Proceedings: AACR Annual Meeting 2019; March 29-April 3, 2019; Atlanta, GA. American Association for Cancer Research, 2019. http://dx.doi.org/10.1158/1538-7445.sabcs18-3383.

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Yeh, Chin-Chia Michael, Yan Zhu, Liudmila Ulanova, et al. "Matrix Profile I: All Pairs Similarity Joins for Time Series: A Unifying View That Includes Motifs, Discords and Shapelets." In 2016 IEEE 16th International Conference on Data Mining (ICDM). IEEE, 2016. http://dx.doi.org/10.1109/icdm.2016.0179.

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Riley, Graham. "MMP and Matrix Degradation in Tendon." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53233.

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Tendons are often affected by chronic pain and rupture, particularly in the middle-aged and elderly, but also in the sporting and physically active younger population. Although not life threatening, these conditions (‘tendinopathy’) are major causes of morbidity, and estimated to cost tens of millions of pounds every year in lost productivity. I have previously shown that the organisation and composition of the tendon extracellular matrix (ECM) are substantially altered in tendinopathy, and that these changes may predispose to tendon pain and rupture. I have also shown that most tendinopathy i
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Chensheng, Ma, Chan Ruth Chau-Ting, and Kwok Wai-Ming. "Ultrafast time-resolved fluorescence study on formation and excitation dynamics of human telomeric and homo-oligomeric i-motifs at neutral pH." In Asian Spectroscopy Conference 2020. Institute of Advanced Studies, Nanyang Technological University, 2020. http://dx.doi.org/10.32655/asc_8-10_dec2020.73.

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Geliashvili, Sopiko. "Unconscious Motifs and Gender Trouble in Djuna Barnes’ Nightwood." In XII Congress of the ICLA. Georgian Comparative Literature Association, 2025. https://doi.org/10.62119/icla.4.9003.

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The above-mentioned article reviews unconscious motifs and gender trouble in Djuna Barnes’ novel Nightwood. American modernist writer, a member of minorities due to her sexual orientation, had always been consi­dered as an eccentric and audacious person in Parisian society. The charac­ters of Nightwood have to fight against their unconscious that is presented not only as the event of specific period of mankind but the problem existing from ancient times to modern life. Djuna Barnes shed light on topics and issues that had rarely been dis­cussed publicly, including non-traditional sexual orient
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Arroita Azkarate, Izaro. "Conflicting Memories and Families in Conflict: Identity and Otherness in Contemporary Basque Literature." In XII Congress of the ICLA. Georgian Comparative Literature Association, 2024. https://doi.org/10.62119/icla.2.8454.

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Contemporary Basque literature shows a clear interest in our conflictive past. A growing number of works deal with the Spanish Civil War, Franco's dictatorship, or all that we commonly call the ‘Basque conflict’. Although there is a variety of literary perspectives and approaches, we can observe some recurring motifs that may be especially significant for understanding the negotiations on memory and identity in the Basque Country. Specifically, I will analyze some narratives in which that Other who can be represented as a perpetrator or as a political opponent (a Falangist, a terrorist), also
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Raporty organizacyjne na temat "I-Motifs"

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Whitham, Steven A., Amit Gal-On, and Victor Gaba. Post-transcriptional Regulation of Host Genes Involved with Symptom Expression in Potyviral Infections. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593391.bard.

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Understanding how RNA viruses cause disease symptoms in their hosts is expected to provide information that can be exploited to enhance modern agriculture. The helper component-proteinase (HC-Pro) protein of potyviruses has been implicated in symptom development. Previously, we demonstrated that symptom expression is associated with binding of duplex small-interfering-RNA (duplex-siRNA) to a highly conserved FRNK amino acid motif in the HC-Pro of Zucchini yellow mosaic virus (ZYMV). This binding activity also alters host microRNA (miRNA) profiles. In Turnip mosaic virus (TuMV), which infects t
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Baszler, Timothy, Igor Savitsky, Christopher Davies, Lauren Staska, and Varda Shkap. Identification of bovine Neospora caninum cytotoxic T-lymphocyte epitopes for development of peptide-based vaccine. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7695592.bard.

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The goal of the one-year feasibility study was to identify specific cytotoxic T-lymphocyte (CTL) epitopes to Neosporacaninum in the natural bovine host in order to make progress toward developing an effective peptide-based vaccine against bovine neosporosis. We tested the hypothesis that: N. caninum SRS2 peptides contain immunogenicCTLepitope clusters cross-presented by multiple bovine MHC-I and MHC-IIhaplotypes. The specific objectives were: (1) Map bovine CTLepitopes of N. caninum NcSRS-2 and identify consensus MHC-I and class-II binding motifs; and (2) Determine if subunit immunization with
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พุทธพรทิพย์, จตุรงค์. งานวิจัยเรื่อง การวิเคราะห์ความหลากหลายพันธุกรรมและความสามารถในการกระตุ้น ระบบภูมิคุ้มกันของโปรตีนทั้ง 12 ชนิดในกลุ่มโปรตีนบนผิวเมอร์โรซอยต์ชนิดที่ 3 ของพลาสโมเดียมไวแวกซ์จากผู้ติดเชื้อมาลาเรียในประเทศไทย. จุฬาลงกรณ์มหาวิทยาลัย, 2019. https://doi.org/10.58837/chula.res.2019.13.

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โปรตีนบนผิวของระยะเมอร์โรซอยต์ชนิดที่ 3 ของเชื้อมาลาเรีย (MSP3) เป็นโปรตีนที่ความสำคัญในการนำมาใช้เป็นองค์ประกอบในการพัฒนาวัคซีนป้องกันโรคมาลาเรีย MSP3 ของ Plasmodium vivax ถูกสร้างขึ้นจากกลุ่มของยีน 12 ชนิดทีมีชื่อเรียงตามตัวอักษรคือ PvMSP-3A ถึง PvMSP-3I โครงสร้างของ PvMSP3 family ประกอบไปด้วยบริเวณที่มีความคล้ายกันในบริเวณ N- และ C-termini โดยส่วนกลางของโปรตีนบางชนิดประกอบด้วยบริเวณที่มีกรดอะมิโน alanine เป็นองค์ประกอบจำนวนมากในระยะห่างที่ชัดเจน ทำให้โปรตีนเหล่านี้มีโครงสร้างเป็นขดเกลียวหลายรอบ (coiled-coil motif) วัตถุประสงค์ของการศึกษาครั้งนี้เพื่อศึกษาความหลากหลายของกลุ่มยีน PvMSP3 famil
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Weiss, David, and Neil Olszewski. Manipulation of GA Levels and GA Signal Transduction in Anthers to Generate Male Sterility. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7580678.bard.

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The original objectives of the research were: i. To study the role of GA in anther development, ii. To manipulate GA and/or GA signal transduction levels in the anthers in order to generate male sterility. iii. To characterize the GA signal transduction repressor, SPY. Previous studies have suggested that gibberellins (GAs) are required for normal anther development. In this work, we studied the role of GA in the regulation of anther development in petunia. When plants were treated with the GA-biosynthesis inhibitor paclobutrazol, anther development was arrested. Microscopic analysis of these
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Palmer, Guy, Varda Shkap, Wendy Brown, and Thea Molad. Control of bovine anaplasmosis: cytokine enhancement of vaccine efficacy. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695879.bard.

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Anaplasmosis an arthropod-born disease of cattle caused by the rickettsia Anaplasma marginale and is an impediment to efficient production of healthy livestock in both Israel and the United States. Currently the only effective vaccines are derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Consequently development of a safe, effective vaccine is a high priority. In this collaborative project we focused
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Yalovsky, Shaul, and Julian Schroeder. The function of protein farnesylation in early events of ABA signal transduction in stomatal guard cells of Arabidopsis. United States Department of Agriculture, 2002. http://dx.doi.org/10.32747/2002.7695873.bard.

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Loss of function mutations in the farnesyltransferase β subunit gene ERA1 (enhanced response to abscisic acid), cause abscisic acid hypersensitivity in seedlings and in guard cells. This results in slowed water loss of plants in response to drought. Farnesyltransferase (PFT) catalyses the attachment of the 15-carbon isoprenoid farnesyl to conserved cysteine residues located in a conserved C-terminal domain designated CaaX box. PFT is a heterodimeric protein comprised of an a and b sununits. The a subunit is shared between PFT and geranylgeranyltransferase-I (PGGTI) which catalyses the attachem
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ชวนชื่น, รุ่งทิพย์, พรเพ็ญ พัฒนโสภณ та ศุภชัย เนื้อนวลสุวรรณ. การเฝ้าระวังการดื้อต่อยาฆ่าเชื้อและยาปฏิชีวนะของ Salmonella spp. และ Escherichia coli ในสายพันธุ์ที่แยกได้ในประเทศไทย : รายงานการวิจัย. จุฬาลงกรณ์มหาวิทยาลัย, 2006. https://doi.org/10.58837/chula.res.2006.87.

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แยก Salmonella enterica จำนวน 257 isolates และ Escherichia coli จำนวน 60 isolates จากตัวอย่างที่ได้จาก ไก่ สุกรและสิ่งแวดล้อมในฟาร์ม ทำการหาค่า minimal inhibitory concentration (MIC) ต่อยาปฏิชีวนะและยาฆ่าเชื้อ ได้แก่ ampicillin (AMP) chloramphenicol (CHP) ciprofloxacin (CIP) erythromycin (ERY) gentamycin (GEN) tetracycline (TET) trmethoprim (TRI) benzalkonium chloride (BKC) chlorhexidine (CHX), copper sulfate (CuSO4) และ zinc chloride (ZnCl2) พบว่า salmonella 162 isolates (63.04%) และ E. coli 50 isolates (83.33%) ดื้อต่อยาปฏิชีวนะอย่างน้อยหนึ่งชนิด ค่า MIC ต่อ BKC, CHX, CUSO4 และ ZnCl2 เกาะกัน
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Altstein, Miriam, and Ronald Nachman. Rationally designed insect neuropeptide agonists and antagonists: application for the characterization of the pyrokinin/Pban mechanisms of action in insects. United States Department of Agriculture, 2006. http://dx.doi.org/10.32747/2006.7587235.bard.

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The general objective of this BARD project focused on rationally designed insect neuropeptide (NP) agonists and antagonists, their application for the characterization of the mechanisms of action of the pyrokinin/PBAN (PK-PBAN) family and the development of biostable, bioavailable versions that can provide the basis for development of novel, environmentally-friendly pest insect control agents. The specific objectives of the study, as originally proposed, were to: (i) Test stimulatory potencies of rationally designed backbone cyclic (BBC) peptides on pheromonotropic, melanotropic, myotropic and
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Altstein, Miriam, and Ronald J. Nachman. Rational Design of Insect Control Agent Prototypes Based on Pyrokinin/PBAN Neuropeptide Antagonists. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7593398.bard.

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The general objective of this study was to develop rationally designed mimetic antagonists (and agonists) of the PK/PBAN Np class with enhanced bio-stability and bioavailability as prototypes for effective and environmentally friendly pest insect management agents. The PK/PBAN family is a multifunctional group of Nps that mediates key functions in insects (sex pheromone biosynthesis, cuticular melanization, myotropic activity, diapause and pupal development) and is, therefore, of high scientific and applied interest. The objectives of the current study were: (i) to identify an antagonist bioph
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