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1

Udeh, Nkeiruka E., and Chinaka O. Nwaehujor. "ANTIOXIDANT AND HEPATOPROTECTIVE ACTIVITIES OF ETHYL ACETATE LEAF EXTRACT OF Icacinia trichantha ON PARACETAMOL-INDUCED LIVER DAMAGE IN RATS." Continental J. Animal and Veterinary Research 3 (June 16, 2011): 11–15. https://doi.org/10.5281/zenodo.818042.

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Studies were conducted on the <em>in vitro</em> anti-oxidant and <em>in vivo</em> hepatoprotective effects of ethyl acetate extract of <em>Icacinia trichantha</em> leaves. Mature Wistar rats weighing 150-200 g were used to study the changes in alanine aminotransaminase (ALT), aspartate aminotranferase (AST), alkaline phosphatase (ALP), bilirubin and protein on paracetamol-induced liver damage in rats. <em>In vitro </em>anti-oxidant assays carried out include 1, 1-Diphenynl-2-Picrylhydrazyl (DPPH) and Ferric Reducing Antioxidant Power (FRAP) Assays. Results showed that <em>I. trichantha </em>le
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2

Zhao, Ming, Brian Guo, Michael M. Onakpa, et al. "Activity of Icacinol from Icacina trichantha on Seedling Growth of Oryza sativa and Arabidopsis thaliana." Journal of Natural Products 80, no. 12 (2017): 3314–18. http://dx.doi.org/10.1021/acs.jnatprod.7b00668.

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Che, Chun-Tao, Ming Zhao, Brian Guo, and Michael M. Onakpa. "Icacina trichantha, A Tropical Medicinal Plant." Natural Product Communications 11, no. 7 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100740.

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This is a review on the pharmacological properties and chemical composition of Icacina trichantha (Icacinaceae), a food and medicinal plant native to West Africa. The tuber is a good source of nutrients such as starch; it also exhibits a variety of pharmacological activities in animal models. Chemical analysis has revealed the presence of a series of unusual pimarane-type diterpenes.
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Guo, Brian, Ming Zhao, Zhenlong Wu, Monday M. Onakpa, Joanna E. Burdette, and Chun-Tao Che. "19-nor-pimaranes from Icacina trichantha." Fitoterapia 144 (July 2020): 104612. http://dx.doi.org/10.1016/j.fitote.2020.104612.

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Xu, Ming-Ming, Junfei Zhou, Liping Zeng, et al. "Pimarane-derived diterpenoids with anti-Helicobacter pylori activity from the tuber of Icacina trichantha." Organic Chemistry Frontiers 8, no. 12 (2021): 3014–22. http://dx.doi.org/10.1039/d1qo00374g.

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Two novel diterpenoids and ten known analogs were obtained from the tuber of Icacina trichantha. All compounds exhibited antibacterial activity against Helicobacter pylori strains with MIC values ranging from 8 to 64 μg mL<sup>−1</sup>.
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Ojah Emmanuel Onah and Kachi Jolly Babangida. "Phytochemical Investigation and Antimicrobial Activity of Hexane, Ethyl Acetate and Methanol Fractions from Stem Bark of Icacina Trichantha Oliv. (Icacinaceae)." Journal of Chemistry, Environmental Sciences and its Applications 7, no. 1 (2020): 7–12. http://dx.doi.org/10.15415/jce.2020.71002.

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Background: Micro-organisms are responsible for the transmission of a large number of diseases. It is hard to comprehend the amount of diseases, deaths and economic losses caused by micro-organisms alone. Plants are good sources of eco-friendly and readily available antimicrobial agents. Purpose: The aim of this study was to evaluate the chemical constituents and antimicrobial characteristics of three fractions from ethnomedicinal Icacina trichantha. Oliv. (Icacinaceae).Methods: Methanol extract from Icacina trichantha. Oliv was obtained by maceration and fractionated successively using hexane
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7

Asuzu, I. U., S. Sosa, and R. Della Loggia. "The antiinflammatory activity of Icacina trichantha tuber." Phytomedicine 6, no. 4 (1999): 267–72. http://dx.doi.org/10.1016/s0944-7113(99)80019-1.

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Shagal, Mohammed Hassan. "Antimicrobial and Phytochemical Screening of Icacina Trichantha." American Journal of Biomedical and Life Sciences 1, no. 2 (2013): 37. http://dx.doi.org/10.11648/j.ajbls.20130102.11.

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Asuzu, I. U., and E. E. Ugwueze. "Screening of Icacina trichantha extracts for pharmacological activity." Journal of Ethnopharmacology 28, no. 2 (1990): 151–56. http://dx.doi.org/10.1016/0378-8741(90)90024-n.

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Guo, Brian, Monday M. Onakpa, Xiao-Jun Huang, et al. "Di-nor- and 17-nor-pimaranes from Icacina trichantha." Journal of Natural Products 79, no. 7 (2016): 1815–21. http://dx.doi.org/10.1021/acs.jnatprod.6b00289.

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Guo, B., M. Zhao, MM Onakpa, et al. "16,17-Dinor- and 17,19-dinor-pimaranes from Icacina trichantha." Planta Medica 81, S 01 (2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596341.

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Asuzu, I. U., and O. K. Egwu. "Search for the centrally active component of Icacina trichantha tuber." Phytomedicine 5, no. 1 (1998): 35–39. http://dx.doi.org/10.1016/s0944-7113(98)80057-3.

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Zhao, Ming, Monday M. Onakpa, Bernard D. Santarsiero та ін. "(9βH)-Pimaranes and Derivatives from the Tuber of Icacina trichantha". Journal of Natural Products 78, № 11 (2015): 2731–37. http://dx.doi.org/10.1021/acs.jnatprod.5b00688.

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Timothy, O., M. Idu, D. I. Olorunfemi, and O. Ovuakporie-Uvo. "Cytotoxic and genotoxic properties of leaf extract of Icacina trichantha Oliv." South African Journal of Botany 91 (March 2014): 71–74. http://dx.doi.org/10.1016/j.sajb.2013.11.008.

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Guo, Brian, Monday M. Onakpa, Xiao-Jun Huang, et al. "Correction to Di-nor and 17-nor-pimaranes from Icacina trichantha." Journal of Natural Products 79, no. 10 (2016): 2765. http://dx.doi.org/10.1021/acs.jnatprod.6b00837.

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Orimisan, Ojatula, Tawose Olakunle, and Erinoso Morenikeji. "Studies on In-vitro Bioactivity of Icacina trichantha Methanol Seed Extract." International Journal of Science for Global Sustainability 9, no. 1 (2023): 13. http://dx.doi.org/10.57233/ijsgs.v9i1.403.

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Plants are new sources of antioxidative and antimicrobial agents, hence the need to determine and evaluate the antibacterial, antifungal properties and antioxidant activity of medicinal plants. The aim of this study was to investigate antioxidant and antimicrobial potentials of methanol extract of Icacina trichantha. Oliv. (Icacinaceae) seed. In this research work, antioxidant study was done by using various in vitro methods such as: 1-Dipheny-2-picrylhydrazyl (DPPH), 2,2-azinobis (3-ethylbenzthiazoline)-6-sulfonic acid) (ABTS), total antioxidant capacity (TAC), nitric oxide (NO) scavenging, h
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17

Otun, Kabir O., Damilola B. Onikosi, Abdulfatai T. Ajiboye, and Akeem A. Jimoh. "Chemical Composition, Antioxidant and Antimicrobial Potentials of Icacina trichantha Oliv. Leaf Extracts." Research Journal of Phytochemistry 9, no. 4 (2015): 161–74. http://dx.doi.org/10.3923/rjphyto.2015.161.174.

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Zhao, Ming, Michael Monday Onakpa, Wei-Lun Chen та ін. "17-Norpimaranes and (9βH)-17-Norpimaranes from the Tuber of Icacina trichantha". Journal of Natural Products 78, № 4 (2015): 789–96. http://dx.doi.org/10.1021/np5010328.

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19

Guo, Brian, Ming Zhao, Zhenlong Wu, Monday M. Onakpa, Joanna E. Burdette, and Chun-Tao Che. "Corrigendum to ‘19-nor-pimaranes from Icacina trichantha’ [Fitoterapia. 144 (2020) 104612]." Fitoterapia 146 (October 2020): 104656. http://dx.doi.org/10.1016/j.fitote.2020.104656.

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Zhao, Ming, Monday M. Onakpa, Bernard D. Santarsiero, et al. "ChemInform Abstract: Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha." ChemInform 46, no. 51 (2015): no. http://dx.doi.org/10.1002/chin.201551182.

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Umoh, E. O., and M. O. Iwe. "Effects of Processing on the Nutrient Composition of False Yam (Icacina trichantha) Flour." Nigerian Food Journal 32, no. 2 (2014): 1–7. http://dx.doi.org/10.1016/s0189-7241(15)30111-9.

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Olayemi, Olutayo, Monday Onakpa, and Olorunfemi Jegede. "In vitro Anthelmintic Activity of Icacina trichantha Leaf Crude Extract and Fractions on Haemonchus contortus." Veterinarski arhiv 92, no. 3 (2022): 331–37. http://dx.doi.org/10.24099/vet.arhiv.1382.

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Haemonchus contortus is an important gastrointestinal parasite of ruminants, which causes anaemia, submandibular oedema, progressive weight loss, weakness and the death of infected animals. This study evaluates the in vitro ovicidal and larvicidal activity of Icacina trichantha leaf crude extract and fractions against the parasite H. contortus eggs and larvae. Phytochemical analysis of the crude extract was carried out using standard procedures to determine the metabolites contained in the plant. The in vitro anthelmintic activity of the crude extract and fractions was determined using egg hat
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23

Akoh, O. U., and O. M. Mac-Kalunta. "Phytochemical Screening and Identification of Bioactive Constituents of the Chloroform Extract of Icacina trichantha Tuber Peel Oliv." Journal of Applied Sciences and Environmental Management 25, no. 7 (2021): 1115–20. http://dx.doi.org/10.4314/jasem.v25i7.3.

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&#x0D; &#x0D; &#x0D; This study was carried out to identify the bioactive constituents of the tuber peels of Icacina trichanthalinna of the Icacinales family. This plant is basically selected due to its widespread use in herbal treatment. Nine compounds were identified in the chloroform extract of the tuber peel. Undecane (43.254%),2-hexanone (23.299%), Dodecanoic acid ethyl ester (6.244%) and 9-octadecynoic acid (5.915%) appeared to be the most prevailing compounds and they are known to possess antibacterial, antiviral, antioxidant, antimycobacterial, hypercholesterolemic activities. Also ide
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24

Okieimen, Ebhodaghe, Osaro Iyekowa, Eribe Jonathan, and Omonkhelin Owolabi. "Uterine Contractile Activity of Extract of Icacina trichantha on Albino Non-Pregnant Rat Uterus." Tropical Journal of Natural Product Research 2, no. 3 (2018): 118–21. http://dx.doi.org/10.26538/tjnpr/v2i3.3.

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Ezeigbo, IhechiluruI. "Antidiabetic potential of methanolic leaf extracts of icacina trichantha in alloxan-induced diabetic mice." International Journal of Diabetes in Developing Countries 30, no. 3 (2010): 150. http://dx.doi.org/10.4103/0973-3930.66511.

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Monday Onakpa, Michael, Ming Zhao, Tanja Goedecke та ін. "ChemInform Abstract: Cytotoxic (9βH)-Pimarane and (9βH)-17-Norpimarane Diterpenes from the Tuber of Icacina trichantha." ChemInform 46, № 20 (2015): no. http://dx.doi.org/10.1002/chin.201520244.

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Zhang, Ruizhen, Yingrun Ma, Ming-Ming Xu, et al. "Oxalactam A, a Novel Macrolactam with Potent Anti-Rhizoctonia solani Activity from the Endophytic Fungus Penicillium oxalicum." Molecules 27, no. 24 (2022): 8811. http://dx.doi.org/10.3390/molecules27248811.

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A novel macrolactam named oxalactam A (1), three known dipeptides (2–4) as well as other known alkaloids (5–7) were obtained from the endophytic fungus Penicillium oxalicum, which was derived from the tuber of Icacina trichantha (Icacinaceae). All chemical structures were established based on spectroscopic data, chemical methods, ECD calculations, and 13C-DP4+ analysis. Among them, oxalactam A (1) is a 16-membered polyenic macrolactam bearing a new skeleton of 2,9-dimethyl-azacyclohexadecane core and exhibited potent anti-Rhizoctonia solani activity with a MIC value of 10 μg/mL in vitro. The p
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Monday, Onakpa Michael, and Asuzu Isaac Uzoma. "Histological changes and antidiabetic activities of Icacina trichantha tuber extract in beta–cells of alloxan induced diabetic rats." Asian Pacific Journal of Tropical Biomedicine 3, no. 8 (2013): 628–33. http://dx.doi.org/10.1016/s2221-1691(13)60127-6.

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IRIBHOGBE, M. E., K. E. IMAFIDON, and O. D. ABU. "BIOCHEMICAL INVESTIGATIONS ON THE EFFECT OF AQUEOUS LEAF EXTRACT OF ICACINA TRICHANTA OLIV. ON UREA, CREATININE AND KIDNEY OXIDATIVE STATUS IN CCL4-INDUCED RENAL DYSFUNCTION IN RATS." Nigerian Journal of Life Sciences (ISSN: 2276-7029) 5, no. 1 (2022): 85–89. http://dx.doi.org/10.52417/njls.v5i1.211.

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Different parts of Icacina trichanta has been used for ethnomedicinal purposes; this study was undertaken to investigate the effects of this plant on CCl4- induced renal damage. Phytochemical analyses were carried out on powdered sample using standard procedures. Absolute organ weight, Urea, creatinine, total protein, superoxide dismutase, catalase and malondialdehyde levels were determined. Consequently, thirty-six male albino rats were divided into six groups of six rats each. They were fed rats‘ chow and water ad libitum. Groups I (normal control) and III were not induced. While group III w
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IC, Oladipo, Ajadi KA, and Ogunsona SB. "In-vitro Anti-hypertensive, Anti-oxidant and Anti-fungal Properties of Green Synthesized Gold Nanoparticles from Icacina Trichantha Leaf Aqueous Extract." Acta Scientific Microbiology 6, no. 7 (2023): 27–34. http://dx.doi.org/10.31080/asmi.2023.06.1271.

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Okosun, S. E., A. S. Eguaoje, and E. T. E. Ehebha. "Hematology and Blood Serum Chemistry of Albino Rat Fed Variously Processed False Yam (Icacina trichantha) Root Tuber at Varying Replacement Levels for Maize." Asian Journal of Research in Animal and Veterinary Sciences 1, no. 2 (2018): 86–93. http://dx.doi.org/10.9734/ajravs/2018/41041.

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Olubomehin, O. O., E. O. Odubote, A. O. Ogunmoye, et al. "Chemical constituents, antimicrobial and antioxidant activities of essential oils from fresh and air-dried leaves of <i>Icacina trichantha</i> (OLIV.)." Scientia Africana 23, no. 3 (2024): 25–36. http://dx.doi.org/10.4314/sa.v23i3.3.

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We investigated and compared the constituents, antimicrobial, and antioxidant activities of the essential oils from the fresh and air- dried leaves of Icacina trichantha. The essential oils were extracted by hydrodistillation, antimicrobial activities were tested on Staphylococcus aureus, Salmonella typhi, Escherichia coli, Pleisomonas shigellosis, Bacillus cereus, Proteus vulgaris, Candida albicans, and Candida tropicalis by agar diffusion method, while 2,2- diphenyl-1-picrylhydrazyl (DPPH) was used for the antioxidant activities at 6.25-200 μg/mL of the oils compared with ascorbic acid as st
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Oladeji, Oluwatoyin Ajoke, and Clement Olusola Ogidi. "Enhancing the Nutritional and Microbiological Properties of Fermented Melon Condiment (Ogiri) Using Newbouldia laevis and Icacina trichantha Leaves." Preventive Nutrition and Food Science 30, no. 3 (2025): 285–94. https://doi.org/10.3746/pnf.2025.30.3.285.

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Onakpa, MM, M. Zhao, T. Gödecke, et al. "Bioactive pimarane diterpenes from Icacina trichantha." Planta Medica 80, no. 10 (2014). http://dx.doi.org/10.1055/s-0034-1382530.

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Akoh, O. U., B. C. Anyanwu, and O. M. Mac-kalunta. "ISOLATION, CHARACTERIZATION AND ANTIMYCOBACTERIAL POTENCY OF A FURAN DERIVATIVE FROM THE CHLOROFORM CRUDE EXTRACT OF Icacina trichantha oliv TUBER." Journal of Chemical Society of Nigeria 49, no. 1 (2024). http://dx.doi.org/10.46602/jcsn.v49i1.956.

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Spectroscopic analysis of a pure isolate (OAU 2, a furan derivative) by column chromatography from the chloroform crude extract of Icacina trichantha tuber was done using FT-IR, 1HNMR, 13CNMR, COSY and was established by literature as well as the investigation of antimycobacterial potency. This anitmycobacterial activity revealed that this isolate actually has activity against DR-TB Strain and H37RV Strain which are American type culture collection strain and multi-drug resistant strains of M. tuberculosis being the test organisms. Hence, confirming the folk believe of the use of I. trichantha
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Abu, O. D., B. M. Aleogho, and F. O. Omoregie. "Extract of Icacina trichanta Improves lipid Profile and CCl4- Induced Histological Changes in Wistar Rats." Asian Journal of Research in Biochemistry, March 7, 2019, 1–11. http://dx.doi.org/10.9734/ajrb/2019/v4i130060.

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Aim: This study was undertaken to investigate the effect of aqueous leaf extract of Icacina trichanta on lipid profile and CCl4- induced histological changes in Wistar rats.&#x0D; Study Design: Liver damage was induced with CCl4 and the rats were treated with aqueous extract of Icacina trichanta.&#x0D; Place and Duration of Study: This study was undertaken at the Department of Biochemistry, Faculty of Life Sciences, University of Benin, Benin City, Nigeria, between January to March 2014.&#x0D; Methodology: Phytochemical screening, lipid profile analysis and histopathological studies were carri
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Zhao, M., MM Onakpa, WL Chen та ін. "Further (9βH)-pimaranes and derivatives from Icacina trichantha". Planta Medica 81, № 11 (2015). http://dx.doi.org/10.1055/s-0035-1556467.

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Alawode, Taye Temitope, Labunmi Lajide, Mary Olaleye та Bodunde Owolabi. "Stigmasterol and β-Sitosterol: Antimicrobial Compounds in the Leaves of Icacina trichantha identified by GC–MS". Beni-Suef University Journal of Basic and Applied Sciences 10, № 1 (2021). http://dx.doi.org/10.1186/s43088-021-00170-3.

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Abstract Background The development of resistance to many antibiotics currently in use has necessitated the search for more effective alternatives. Plants have been used in ethnomedicine in different parts of the world to treat various diseases. Many studies on plants have confirmed their medicinal potentials and have led to the isolation and characterization of several potential drug candidates. This study investigates the leaves of Icacina trichantha for antimicrobial properties and seeks to identify the compounds responsible for the observed activities. The leaves of Icacina trichantha are
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Onakpa, MM, T. Gödecke, M. Zhao, BD Santarsiero, AI Uzoma та CT Che. "9β-Pimarane Diterpenes from the Tuber of Icacina trichantha". Planta Medica 79, № 10 (2013). http://dx.doi.org/10.1055/s-0033-1348684.

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KADİRİ, Akeem, Olayinka ASEKUN, Kelechi ASEKUNOWO, Emmanuel AYODELE, and James OLOWOKUDEJO. "Morpho-anatomical and phytochemical evaluation of Icacina trichantha Oliver (Icacinaceae)." Anatolian Journal of Botany, October 15, 2020. http://dx.doi.org/10.30616/ajb.774653.

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Timothy, O., I. Igbe, and M. Idu. "Anti-inflammatory and antinociceptive activities of aqueous leaf extract of Icacina trichantha Oliv. in rodents." Nigerian Journal of Pharmaceutical Sciences, September 2015. https://doi.org/10.1016/j.nijps.2015.09.005.

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Agbo, I. U., and G. E. Odo. "The Effect of Hypochlorite Oxidation and Acetylation on Some of the Physicochemical Properties of Icacina Trichantha Starch." Bio-Research 8, no. 1 (2010). http://dx.doi.org/10.4314/br.v8i1.62539.

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"GC-MS Analysis and Molecular Docking Studies to Identify Potential SARS-CoV-2 Nonstructural Protein Inhibitors from Icacina trichantha Oliv Tubers." Tropical Journal of Natural Product Research 6, no. 8 (2022): 1337–42. http://dx.doi.org/10.26538/tjnpr/v6i8.29.

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Onakpa, Monday Michael, Julius Okwoche Ode, Victor Olumayowa Kolawole, Peter Olatunde Ajagbonna, and Isaac Uzoma Asuzu. "Evaluation of the Hypoglycemic Activity of Methanol Extract of Icacina Trichantha Tuber in Alloxan‐Induced Diabetic Rats and Isolation of the Active Principle." FASEB Journal 33, S1 (2019). http://dx.doi.org/10.1096/fasebj.2019.33.1_supplement.504.7.

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"Bioactivity guided fractionation of Icacina trichantha Oliv. (Icacinaceae) tuber for antimalarial activity against Plasmodium berghei infected mice and GC-MS profile of bioactive fraction." Indian Journal of Traditional Knowledge 20, no. 4 (2021). http://dx.doi.org/10.56042/ijtk.v20i4.27188.

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