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Gotowe bibliografie tematyczne / Immune related diseases / Rozprawy doktorskie

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Rozprawy doktorskie na temat „Immune related diseases”

Autor: Grafiati

Data publikacji: 2 czerwca 2025

Data aktualizacji: 31 lipca 2025

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1

Sotillo, Rodríguez Fernando. "Pathophysiology of immune-related complications in Lysinuric Protein Intolerance." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/463008.

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Lysinuric Protein Intolerance (LPI, MIM #222700) is a rare autosomic disease caused by mutations in SLC7A7 gene. Hallmarks of LPI are malabsorption and deficient renal reabsorption of cationic amino acids, which drives a deficit in the functioning of the urea cycle due to the reduction levels of arginine and ornithine in plasma. Nevertheless LPI patients also develop immune and hematologic complications such as anemia, pulmonary alveolar proteinosis or hemophagocytic lymphohistiocytosis. However the molecular mechanism(s) and/or the initiation events that trigger the development of LPI immune

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Onyebuchi, Iroezindu Michael. "Prevalence of HIV-related opportunistic diseases amongst HAART patients at the Federal Medical Centre in Owerri, Nigeria." Thesis, University of the Western Cape, 2012. http://hdl.handle.net/11394/5200.

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Magister Public Health - MPH<br>Background: The hallmark of HIV infection is immunosuppression which predisposes to unusual infections and malignancies generally known as opportunistic diseases (ODs). Globally, ODs are the major cause of morbidity and mortality in people living with HIV (PLHIV). Since the advent of Highly Active Antiretroviral Therapy (HAART), a significant decline in AIDS progression and ODs has been observed globally. However, most of the evidence suggesting sustained decline in AIDS progression and ODs has come from high-income settings with relatively less burden of ODs i

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Kitzmiller, Kathryn Jean. "Variation of Complement Factor H and Mannan Binding Lectin in Human Systemic and Vascular Immune-Mediated Diseases." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1261493418.

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Hardy, Olga T. "Role of the Monocyte/Macrophage Cell Lineage in Obesity-Related Insulin Resistance." eScholarship@UMMS, 2010. https://escholarship.umassmed.edu/gsbs_diss/464.

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Background Obesity is an important risk factor for resistance to insulin-mediated glucose disposal, and is a precursor of type 2 diabetes and other disorders. Objectives To identify molecular pathways in adipose tissue and inflammatory cells that may result in obesity-associated insulin resistance, we exploited the fact that not all obese individuals are prone to insulin resistance. Thus the degree of obesity as a variable was removed by studying obese subjects of similar body mass index (BMI) who are insulin-sensitive (IS) versus insulin-resistant (IR). Methods Combining gene expression profi

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Kühl, Thomas. "Pathogenic impact of immune-related cells in Batten disease." Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/pathogenic-impact-of-immunerelated-cells-in-batten-disease(ff86b71b-e859-4d91-a378-421eab71ae97).html.

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The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are inherited neurodegenerative diseases of children. In all types of NCL glial activation, the innate immune response of the brain, precedes neurodegeneration. However, it is unclear whether adaptive immune responses are also involved in these diseases, or if they directly contribute to disease pathogenesis. Therefore, we examined the role of adaptive immune cells in mouse models of Infantile NCL (Ppt1-/- mice) and Juvenile NCL (Cln3-/- mice) by identifying, localising, and subsequently genetically removing immune components. Charact

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Parzych, Katarzyna. "The role of innate immune system receptors in smoking related disease." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/14371.

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Cigarette smoke induces inflammation, in part, by activation of Toll like receptor (TLR) 2 and TLR4. TLRs are present on most cells and recognize pathogen associated molecular patterns (PAMPs) and non-pathogenic molecules, known as danger associated molecular patterns (DAMPs). Activation of TLRs results in the propagation of a signalling pathway leading to the de novo synthesis of pro-inflammatory mediators that include CXCL8 and IL-1β. TLRs initiate inflammation and are involved in tissue repair processes in a number of diseases such as chronic obstructive pulmonary disease (COPD) and cancer.

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Coleman, Nicholas. "The local immune response to human papillomavirus-related disease in the female genital tract." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319959.

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8

Hampson, Judith Anne. "Immune activation in alpha-1 antitrypsin deficiency related and usual chronic obstructive pulmonary disease." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8473/.

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A polyclonal increase in free light chains (FLCs) has been observed in a number of chronic inflammatory and autoimmune conditions and may be considered a biomarker of adaptive immune activation. The aim of this study was to examine whether FLCs could be a useful clinical biomarker in alpha-1 antitrypsin deficiency (A1ATD) and chronic obstructive pulmonary disease (COPD). Combined (\(\kappa\) & \(\lambda\)) FLCs (cFLCs) were measured in patients with AlATD and usual COPD in the stable state and assessed for association with clinical phenotype, disease severity, bacterial colonisation and mortal

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9

Mooney, John. "Molecular and cellular aspects of the humoral immune response in periodontal disease and other related conditions." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321510.

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Bogner, Simon Sebastian [Verfasser], та Markus [Akademischer Betreuer] Glatzel. "Immune activation in Aβ-related angiitis (ABRA) and a cell model of E280A presenilin-mutated Familial Alzheimer's Disease / Simon Sebastian Bogner. Betreuer: Markus Glatzel". Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1059859823/34.

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PANICUCCI, CHIARA. "The role of inflammation on disease progression in alpha-sarcoglycan-related limb girdle muscular dystrophy (LGMDR3): new insights from human histological analysis and in vivo studies on Sgca-null mice." Doctoral thesis, Università degli studi di Genova, 2022. http://hdl.handle.net/11567/1080120.

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Limb Girdle Muscular Dystrophy R3 (LGMDR3), previously known as LGMD2D, is a rare autosomal recessive primary myopathy, clinically characterized by progressive involvement of the pelvic and shoulder girdles, and genetically by mutations in the αsarcoglycan gene (SGCA) coding for α-sarcoglycan (SG). The clinical course of LGMDR3 presents a great variability, ranging from severe form with onset in the first decade of life and rapid progression, to milder form with later onset. Currently, physical therapy and prevention of secondary cardiac, pulmonary or orthopedic complications are the only po

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12

Caesar, Mareike [Verfasser]. "Cellular and systemic effects of Parkinson’s disease-related LRRK2 mutations: An investigation of cytoskeletal function and the innate immune system in transgenic mice and human LRRK2 mutation carriers / Mareike Caesar." Ulm : Universität Ulm, 2016. http://d-nb.info/1098309545/34.

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13

Sowers, Kerri. "Impact of an Exercise Program on Stress, Fatigue, and Quality of Life for Individuals Living with Primary Immunodeficiency Disease." Diss., NSUWorks, 2018. https://nsuworks.nova.edu/hpd_pt_stuetd/63.

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Background: There are over 300 Primary Immunodeficiency diseases (PID) that are a result of a genetic or idiopathic dysfunction of any aspect of the immune system. These conditions result in a higher frequency of infections, autoimmune conditions, or malignancies. Moderate intensity exercise is thought to help the immune system, while high intensity exercise may have a negative impact on immune function. The impact of exercise on individuals with an impaired immune system due to PID is not yet understood. Purpose: The purpose of this study was to investigate whether a low to moderate intensity

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Tavares, Lucas Alves. "O envolvimento da proteína adaptadora 1 (AP-1) no mecanismo de regulação negativa do receptor CD4 por Nef de HIV-1." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-06012017-113215/.

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O Vírus da Imunodeficiência Humana (HIV) é o agente etiológico da Síndrome da Imunodeficiência Adquirida (AIDS). A AIDS é uma doença de distribuição mundial, e estima-se que existam atualmente pelo menos 36,9 milhões de pessoas infectadas com o vírus. Durante o seu ciclo replicativo, o HIV promove diversas alterações na fisiologia da célula hospedeira a fim de promover sua sobrevivência e potencializar a replicação. A rápida progressão da infecção pelo HIV-1 em humanos e em modelos animais está intimamente ligada à função da proteína acessória Nef. Dentre as diversas ações de Nef está a regula

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15

Cunha, Ana Filipa Nina e. "Diagnostic methods for immune-related pulmonary diseases." Master's thesis, 2018. http://hdl.handle.net/10773/25080.

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The development of clinical laboratory assays to help interpret medical examination is essential for the early diagnosis of rare diseases, facilitating their management and treatment. Two diseases were studied in this project: autoimmune pulmonary alveolar proteinosis (aPAP) and chronic hypersensitivity pneumonitis (HP). Granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody is a biomarker of autoimmune pulmonary alveolar disease, with elevated levels resulting in impaired GM-CSF signalling, and on the surfactant alveolar accumulation and consequently lung dysfunction. This pr

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16

Green, Robin J. "Atopy and acquired immune deficiency - issues of control of two extremes of a spectrum of paediatric respiratory disorders with an immunological basis." Thesis, 2013. http://hdl.handle.net/2263/32940.

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Twenty publications are submitted. All deal with the issues of control of two ends of the spectrum of immune-mediated respiratory disorders in children, namely atopic (asthma and allergic rhinitis) and HIV-related lung disease. This submission summarises the research by the author into this spectrum of lung diseases of children in South Africa, highlighting the diversity of conditions that are not only clinically important, but also common. Understanding of all conditions is required to improve the health of children in this region. Management of chronic conditions requires two major en

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17

"The association between immune response genes and apolipoprotein E (ApoE) related genes in the predisposition for Alzheimer's disease." 2003. http://library.cuhk.edu.hk/record=b5891456.

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by Ma Suk Ling.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 2003.<br>Includes bibliographical references (leaves 106-129).<br>Abstracts in English and Chinese.<br>Abstract --- p.i<br>摘要 --- p.iii<br>Acknowledgements --- p.v<br>Publications --- p.vi<br>Abbreviations --- p.vii<br>Chapter Chapter 1 --- General Introduction --- p.1<br>Chapter 1.1 --- Epidemiology of AD --- p.2<br>Chapter 1.2 --- Clinical and pathological features of AD --- p.3<br>Chapter 1.2.1 --- Clinical features of AD --- p.3<br>Chapter 1.2.2. --- Pathological features of AD --- p.3<br>Chapter 1.3 --- Diagno

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18

Zhang, Yuanyuan [Verfasser]. "Target detection processing correlates with Borna disease virus specific circulating immune complexes in obsessive compulsive disorder : an event related potential study / by Yuanyuan Zhang." 2004. http://d-nb.info/983270961/34.

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