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Rozprawy doktorskie na temat „Immune response Molecular aspects”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 lutego 2023

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1

Morley, Sarah Louise. "Molecular aspects of the humoral immune response against Neisseria meningitidis." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424765.

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2

Wong, Lik-wai Benny, and 黃力偉. "Immune response and signaling mechanisms of Helicobacter pylori induced gastritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43224313.

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3

Prabhala, Rao H. "Two different molecular pathways of immunomodulation by retinoids and carotenoids." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184676.

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Epidemiological studies suggest that both retinoid and carotenoid intakes are inversely correlated with the incidence of human cancers. Animal studies show that both retinoids and carotenoids inhibit tumor cell growth. Both retinoids and carotenoids activate the cytotoxicity function of macrophages in animal experiments. The purpose of this study is to evaluate the molecular mechanism for 13-cis retinoic acid (13-cRA) and beta-carotene (BC) induced immunomodulation which could explain their anti-cancer affects. The effects of 13-cRA and BC were studied on various subpopulations of T-lymphocyte

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4

Swanson, Kara M., and n/a. "The bovine mammary gland immune response to Streptococcus uberis and its bacteriocins." University of Otago. Department of Microbiology & Immunology, 2008. http://adt.otago.ac.nz./public/adt-NZDU20080407.112302.

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Bovine mastitis is one of the most costly dairy-based diseases worldwide. Streptococcus uberis is a prevalent causative organism of mastitis and resides naturally in the environment of the dairy cow making prevention of the disease difficult. New strategies need to be developed to control this pathogen. However, a fundamental understanding of the complex relationships that exist between the cow, the pathogen and the environment are required in order to advance the development of prevention strategies. Microarray technology was used to evaluate the complex transcriptional changes which occur in

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5

Chakravarti, Sumone. "The cloning and functional characterisation of murine phosphatidylinositol 3-kinase gamma." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09phc4355.pdf.

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6

Mooney, John. "Molecular and cellular aspects of the humoral immune response in periodontal disease and other related conditions." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321510.

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7

Sumaria, Nital. "The relevance of specific molecular and cellular effectors during murine cytomegalovirus infection." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0116.

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[Truncated abstract] The design and development of effective anti-viral immunotherapies requires a comprehensive understanding of the cellular and molecular processes that are involved in the generation and regulation of immune responses. The fundamental objective of the immune system is to successfully complete the task of eliminating/controlling the invading pathogen without causing overt pathology. Cytomegaloviruses (CMVs) are large DNA viruses that are able to evade immune attack and persist lifelong within the host. In a healthy host, CMV causes an asymptomatic infection, but in instances

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8

Andrews, Daniel Mark. "Effects of murine cytomegalovirus infection on dendritic cell functionality and natural killer cell responses." University of Western Australia. Centre for Ophthalmology and Visual Science, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0003.

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Cytomegaloviruses (CMVs) are ubiquitous in nature, having evolved over many millenia with their hosts. While in healthy hosts most infections with CMV are asymptomatic, the virus can cause severe disease in immunocompromised hosts. Thus, the increase in organ transplantation and the HIV/AIDS pandemic have established human CMV (HCMV) as a clinically important pathogen. Indeed, HCMV infections are now the major cause of morbidity and mortality among immunocompromised patients, which has led to more research targeting CMV for effective anti-viral treatment. The discovery that cytomegaloviruses e

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9

Kodituwakku, Aruna Poojitha. "Antigen specific B cells in the immune response to Haemophilus influenzae type b PRP conjugate vaccine /." Title page, table of contents and summary only, 2004. http://web4.library.adelaide.edu.au/theses/09PH/09phk769.pdf.

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10

Khong, Andrea. "Effect of murine cytomegalovirus infection on haematopoiesis and myeloid cell differentiation and function." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0260.

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Cytomegalovirus (CMV) is a ubiquitous pathogen affecting over 95% of the worlds population. While infection is typically asymptomatic in healthy individuals, the virus persists life-long in its host and can be reactivated following withdrawal of immune control. As such, it remains a serious clinical concern in individuals who are immunocompromised, such as newborns and neonates, transplant and/or chemotherapy recipients, and HIV/AIDS patients. CMV also has the ability to cause immunosuppression, the mechanisms of which include defective antigen presentation to T cells and interference with ha

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11

Cheung, Ka-wa Benny, and 張嘉華. "Immune regulation in response to mycobacterial infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B39634206.

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12

Naor, Naftaly. "The immune response against p53 protein in cancer patients /." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69652.

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Mutations in the p53 gene are known to be associated with a wide range of human tumors. In some primary tumors and established cell lines, stable mutant p53 protein is expressed at high levels, whereas, in normal cells unstable wild-type p53 protein is expressed at very low levels. Sera from some patients with breast and colon tumors contain anti-p53 antibodies. It is unclear whether changes in p53 structure, or its increased level in tumors, causes p53 to become antigenic. In our study we tested sera from patients with various types of cancer for anti-p53 antibodies. Examination of the sera w

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13

Kendall, Elaine. "Molecular characterisation of the human major histocompatibility complex." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333402.

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14

Waight, Sharma Agnes Phyllis. "The intestinal immune response to Giardia in the rat." Title page, abstract and contents only, 1988. http://web4.library.adelaide.edu.au/theses/09PH/09phw138.pdf.

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15

Parsa, Venkata Laxmi Kishore. "Molecular mechanisms of host cell response to Francisella infection." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1195584597.

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16

Lange, Christina [Verfasser]. "Molecular analysis of the innate immune response in hydra / Christina Lange." Kiel : Universitätsbibliothek Kiel, 2010. http://d-nb.info/1030344787/34.

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17

Cheung, Ka-wa Benny, and 張嘉華. "Mechanism of Bacillus Calmette Guerin-induced immune response." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29488989.

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18

Robinson, Stephen Paul. "Developmental aspects of normal and malignant dendritic cells." Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325518.

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19

Dajani, Rana Basem. "Innate immune responses in the lung and liver." Diss., University of Iowa, 2005. http://ir.uiowa.edu/etd/103.

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20

Pascoe, E. W. "Cellular aspects of the immune response against Nematospiroides dubius in the mouse." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374814.

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21

Burrows, Amanda Susan. "Cellular aspects of the immune response of the turbot, Scophthalmus maximus (L.)." Thesis, University of Plymouth, 1995. http://hdl.handle.net/10026.1/1990.

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Peripheral blood leucocytes of the turbot, Scophthalmus maximus, were characterised into 4 distinct groups following morphological, morphometric and histochemical examination. Total and differential cell counts were determined. Thrombocytes, the most abundant leucocyte type (52%), were highly mobile and encountered in several morphological forms. Granulocytes, representing 5.6% of the leucocyte population, histochemically most resembled the mammalian neutrophil. Both large and small lymphocytes (40.8%), were encountered. Monocytes were rarely observed (1.6%). Thrombocytes and monocytes were ph

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22

Sparkes, Andrew Howard. "Aspects of feline dermatophytosis and the immune response to Microsporum canis infection." Thesis, University of Bristol, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385524.

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23

Effertz, Bernard Stephen. "The humoral immune response to streptococcal cell wall-induced arthritis in the rat." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184877.

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I investigated the humoral immune response to streptococcal cell walls (SCW) in arthritis susceptible Lewis and resistant Fisher rats. All rats were given a single intraperitoneal injection of either SCW or saline (controls). Rats were sacrificed, three rats per time point, over an eleven week period and serum was collected for ELISA. SCW injected Lewis rats produced anti-SCW antibody, whereas control rats did not. Anti-SCW antibody was significantly elevated over controls between days 14-28 (post injection). Both saline and SCW injected Fisher rats produced anti-SCW antibody, but with differe

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24

吳越 and Yuet Wu. "The study of immune response to co-infection of influenza virus and Streptococcus pneumoniae." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/193417.

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Influenza is a leading cause of respiratory disease worldwide. During pandemic and seasonal influenza, secondary Streptococcus pneumoniae infection is a severe complication that contributes to morbidity and mortality. With the clinical significance of this co-infection, it is imperative to understand the disease mechanisms and how our immune system would be modulated in dealing with the dual infection. First, in vivo co-infection model was established. Mice were sequentially infected with influenza virus and then Streptococcus pneumoniae. Co-infected mice lost their body weight significantl

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25

Sowers, Kegan. "Decellularized Matrices Effect on the Adaptive Immune Response." VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5698.

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Decellularized extracellular matrices have been a growing area of interest in the biomedical engineering fields of tissue engineering and regenerative medicine.As these materials move toward clinical applications, the immune response to these materials will be a driving force toward their success in clinical approaches. Fully digested decellularized matrix constructs derived from porcine liver, muscle and lung were created to test the adaptive immune response. Hydrogel characterization ensured that the materials had relatively similar stiffness levels to reduce variability, and in vitro studie

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26

Shidrawi, Ray Georges. "Molecular immune aspects of coeliac disease : organ culture and peptide binding studies." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243337.

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27

Teng, Ooiean, and 丁瑋嫣. "Identification of CLEC5A in modulating host immune response after influenza A virus infection." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208615.

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Human infections with influenza A virus (IAV) exhibit mild to severe clinical outcomes as a result of differential virus-host interactions. C-type lectin receptors (CLRs) are pattern recognition receptors that may sense carbohydrates, proteins, or lipids derived from infected hosts or the invading microbes including bacteria, viruses, fungi, or parasites. CLR-viral interaction may lead to increased viral entry and spread; furthermore, their interactions have been reported to trigger downstream signaling that further modulates host’s innate immune responses through the induction of pro-inflamma

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28

Beltran, Caroline Gina Gracieuse. "A proteomic investigation of the immune response of the South African abalone, Haliotis midae." Doctoral thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/16483.

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Includes bibliographical references<br>Haliotis midae is a commercially important abalone in South Africa, previously harvested from a stable, quota-managed fishery. However, the combined effects of overharvesting, increased illegal catches and negative environmental factors led to a collapse in wild populations in the mid-90s. Consequently, land-based aquaculture of H. midae has grown significantly in South Africa, to satisfy the global demand for abalone and alleviate pressure on wild stocks. Unfortunately, disease outbreaks have had a severe impact on the abalone aquaculture industry intern

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29

Mee, Edward. "Manipulation of the immune response to malaria antigens using bacterial-derived lipoproteins." Thesis, University of Oxford, 2004. http://ora.ox.ac.uk/objects/uuid:c98c8f59-092d-482c-b159-6033b9844908.

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30

Pretorius, Alri. "Aspects of the immune response in ruminants to four protective Ehrlichia ruminantium gene products." Thesis, University of Pretoria, 2007. http://hdl.handle.net/2263/26758.

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In the search for a better vaccine against Ehrlichia ruminantium infection in ruminants, four E. ruminantium open reading frames (ORFs) derived from the Welgevonden isolate were tested using either DNA vaccination or DNA primemodified viral or DNA prime-recombinant protein boost strategies. Both the DNA vaccination and the DNA prime.recombinant protein boost strategy provided complete protection against E. ruminantium Welgevonden needle challenge, while the DNA prime.modified viral boost strategy only provided 90 % protection. The DNA prime.recombinant protein boost strategy also coincided wit

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31

Daniels, Brodie Belinda. "Molecular and cellular analysis of the interaction between soluble CD23 and CD11/CD18 integrins." Thesis, Nelson Mandela Metropolitan University, 2010. http://hdl.handle.net/10948/1217.

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The low affinity IgE receptor, CD23, is expressed by a wide variety of cells and cleaved from its original 45 kDa size to several smaller soluble CD23 proteins. Soluble CD23 function depends on the form of the protein and its interaction with various ligands. CD23 is believed to play an important role in regulating allergic responses and in inflammation, amongst others. β2 integrins are important in a variety of cell-adhesion reactions during immune-inflammatory mechanisms and the binding of their natural ligands generates outside-in cellular signalling, leading to cell activation. Although th

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32

D'Souza, Sameer Dominic. "Response of human oligodendrocytes to immune-mediated injury : selective vulnerability and selective protection." Thesis, McGill University, 1996. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=40343.

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This thesis studying the injury response of human central nervous system (CNS)-derived oligodendrocytes (OL) to immune mediated effector mechanisms and its relevance to protective strategies for OL, assessed the basis for the selective injury of OL, as occurs in the human demyelinating disease multiple sclerosis (MS). This thesis tested the postulate that selective target injury within the CNS may reflect target-cell rather than effector-cell properties. Differences in susceptibility of CNS neural cells to a common immune mediator or the cell-specific expression of a surface receptor for a put

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33

Lewis, Teresa D. "The specific immune response in rainbow trout: Somatic hypermutation and VH gene utilization." W&M ScholarWorks, 2000. https://scholarworks.wm.edu/etd/1539616739.

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The study of antibody responses in prominent aquaculture species such as the rainbow trout, Oncorhynchus mykiss, can facilitate vaccine development and contribute to producing useful paradigms of adaptive immunity in lower vertebrates. Thus, it is essential to identify genes responsible for antibody responses. In the mouse model, hybridoma technology allows for the association of monoclonal antibodies possessing various affinities for antigen with specific VH sequences, gene family utilization, and other molecular events (i.e. somatic hypermutation) that occur during the specific immune respon

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34

Angelopoulou, Katerina. "Immune response against the p53 tumor suppressor gene product, clinical studies and molecular mechanisms." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0014/NQ27598.pdf.

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35

Baxendale, Helen Elizabeth. "Analysis of the molecular basis of the immune response to streptococcus pneumoniae capsular polysaccharide." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252064.

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36

Pereira, Melanie Claire. "The molecular analysis of the interation surface between sCD23 and the B2-integrins, CD11b & CD11c." Thesis, Nelson Mandela Metropolitan University, 2012. http://hdl.handle.net/10948/d1014734.

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Both CD23 and the β2 integrins (also known as CD11/CD18) have very important immunological functions, especially during the allergic response where the binding of CD23 to β2 integrins contributes to various types of signalling in monocytes which can result in drastic sensitivities experienced by some allergic individuals. CD23, also known as the low affinity receptor for immunoglobulin E or (FcεRII), is a type II transmembrane glycoprotein which is synthesized by haematopoietic cells and has biological activity in both membrane-bound and freely soluble forms. It acts via a number of receptors,

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37

Wu, Yuet, and 吳越. "Immune response of human monocyte-derived dendritic cells to co-infection of influenza virus and Streptococcus pneumoniae." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45543732.

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38

Bowers, Desiree Ann. "Immune responses of patients with tuberculosis and healthy controls of different ages." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53457.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: The immune system matures progressively from infancy to adulthood, thus children may differ from adults in their immune function. The immature immune system demonstrates a higher naive to memory T cell ratio, defective macrophage function and antigen presentation which, cumulatively, results in diminished production of cytokines such as IFN-y. This cytokine has been shown to play a pivotal role in protection against Mycobacterium tuberculosis (M. tuberculosis) disease. Other cytokines, such as IL-12 and TNF-a, are also in

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39

Tsoi, Hoi-wah, and 蔡海華. "Effect of antibiotics on the immune response induced by live-attenuated Salmonella typhi." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31223540.

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Khan, Deena. "Molecular Basis of Upregulation of IL-17 in Estrogen Model of Inflammation." Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/77129.

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Interleukin-17 (IL-17) plays a major role in inflammation by regulating the induction of various proinflammatory genes, which aid in the recruitment and activation of neutrophils. Although IL-17 is considered to be protective in infection, overproduction of IL-17 in conditions like autoimmune diseases has been shown to aggravate these diseases and contribute to tissue injury. One of the principal focus of our laboratory is to decipher molecular mechanisms involved in inflammatory cytokine regulation and response in inflammatory disorders. To study this aspect, we employ a murine model of pro-i

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Luo, Ying, and 羅英. "Hepatitis B virus: specific immune response after liver transplantation for chronic hepatitis B." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B3697724X.

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42

Yin, Han. "MOLECULAR ANALYSIS OF HTLV-2 APH-2 IN VIRAL TRANSFORMATION, PERSISTENCE AND HOST IMMUNE RESPONSE." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1322156034.

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Conley, Travis B. "Growth response to resistance exercise : influence of exercise device." Virtual Press, 2008. http://liblink.bsu.edu/uhtbin/catkey/1395457.

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The purpose of this study was to compare the growth response elicited by an acute bout of resistance exercise (RE) conducted on a traditional weight stack device (WS) and a flywheel device (FW). Eight recreationally trained males (25 ± 9 y, 77 ± 27 kg) performed 4 sets of 7 repetitions of bilateral knee extension on each exercise device separated by 7 days. Muscle biopsies were obtained from the vastus lateralis at rest and 4 hrs post-exercise to examine the expression of selected myogenic and proteolytic genes. RE increased (P < 0.05) mRNA expression of Myogenin (3.6 vs. 3.6 fold), and MyoD (

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Green, Michelle G. "Respiratory Syncytial Virus Pathogenesis and Immune Response in the Cotton Rat Model." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1492720984529555.

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Abebayehu, Daniel. "MODULATING THE INNATE IMMUNE RESPONSE TO ELECTROSPUN SCAFFOLDS AND POLYMER DEGRADATIVE BYPRODUCTS." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/4739.

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Implanted biomaterials often induce inflammation that frequently leads to the foreign body response, fibrosis, and the failure of the implant. Thus, it is important to evaluate how cells interact with materials to promote a more regenerative response. It is critical to determine how to modulate the response of tissue resident innate immune cells, as they are among the first cells to interact with implanted materials. Among tissue resident innate immune cells are mast cells, which are inflammatory sentinels that degranulate and orchestrate the fate of other cell populations, such as monocytes/m

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46

Schölvinck, Elisabeth Henriëtte. "The influence of age on the cellular immune response in patients with tuberculosis and healthy controls." Thesis, Stellenbosch : Stellenbosch University, 2002. http://hdl.handle.net/10019.1/53126.

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Thesis (PhD) -- Stellenbosch University, 2002.<br>ENGLISH ABSTRACT: Children and adults may differ in their immune function. An adequate function of the individual's immune system is crucial to the risk for development of tuberculosis (TB) after infection with Mycobacterium tuberculosis (Mtb). Epidemiological evidence suggests an age-related incidence of TB. Furthermore, the prevailing clinical expression t ' of TB varies between age groups. -The aims of this study were to characterise the cellular immune response at different ages in TB patients and healthy individuals living in a reg

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47

Hedin, Skogman Barbro. "Neuroborreliosis in childhood : Clinical, immunological and diagnostic aspects." Doctoral thesis, Linköpings universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11520.

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Lyme Borreliosisis is a multi-organ infectious disease caused by the spirochete Borrelia burgdorferi. The spirochete is transmitted to humans by tick bites. Neuroborreliosis (NB) is a disseminated form of the disease, in which the spirochetes invade the nervous system. In children, subacute meningitis and facial nerve palsy are typical clinical manifestations of NB. The aim of this thesis was to study clinical, immunological and laboratory characteristics in children being evaluated for NB in a Lyme endemic area of Sweden, in order to identify factors of importance for prognosis and clinical r

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48

Izadi, Shavakand Fariba. "A molecular genetic survey of immune response genes and biodiversity of industrial and non-industrial chickens." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/36959.

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The current practices in industrial poultry breeding developed specialized production lines from very few breeds, resulting in reducting in genetic diversity. “Free run/free range” production systems (non-industrial) are a more recent trend in the poultry sector. Non-industrial chicken populations may differ genetically and have more diversity in disease resistance genes than industrial populations. To test this hypothesis, six chicken populations from non-industrial source; Silkies (SK), Taiwanese Cross (TC), Shiqi (SQ), Yellow Shiqi (YSQ), Yellow Wai-Chow (YW), and Agassiz Cross (AC), and in

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49

Didriksen, Nancy A. (Nancy Andrews). "The Effect of Examination Stress on Phagocytic Immune Functioning." Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc500983/.

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The purpose of this study was to determine whether psychological stress, specifically examination stress, would decrease immune system functioning. Twenty-five first-year master's and doctoral students who volunteered to participate in the study were psychologically and immunologically assessed during two high- and two low-stress periods. Immunological assessments included a white blood cell differential count and nitroblue tetrazolium test (NBT) to measure neutrophil functioning. Psychological instruments administered at each assessment period included Clinical Analysis Questionnaire (CAQ),

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Gangadharan, Bagirath. "Structural and functional aspects of factor viii in the initiation of the anti-factor viii immune response." Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066257/document.

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L’apparition d’une réponse immunitaire contre le Facteur VIII (FVIII) de la coagulation est une complication majeur qui survient chez 30% des hémophile A sévères. Bien que des avancées importantes aient abouti au développement de nouvelles molécules de FVIII thérapeutiques, les mécanismes conduisant à l’apparition d’une réponse immunitaire anti-FVIII restent non élucidés. Des facteurs de risques génétiques et environnementaux ont été identifiés ou suggérés, mais une compréhension complète des processus immunologiques permettant l’initiation de cette réponse au dépend de l’induction de toléranc

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