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Rozprawy doktorskie na temat „Immunity”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Daneshvar, Fatemeh. "L’immunité juridictionnelle des États et des organismes d'État." Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0270.

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L'immunité juridictionnelle des États a été pendant des siècles une question incontestée fondée sur le principe de l'égalité des Etats et sur leur indépendance absolue. Cette règle a été élaborée à une époque où tenter une action contre un État dans un pays étranger aurait été considéré comme une violation de sa souveraineté. Toutefois, les fonctions des Etats ont changé au cours des siècles. Désormais, les Etats s’engagent dans les activités commerciales comme une personne privée et jouent un rôle essentiel dans ce secteur.Alors, bien que le droit de l'immunité soit lié à l'octroi de l'immuni

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2

Alculumbre, Solana. "Division of Labor Between Distinct Human Plasmacytoid Dendritic Cell Subsets Following Viral Activation." Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS014.

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L’existence d’un partage des tâches a été démontrée au sein de nombreux systèmes biologiques et ce notamment en immunologie où il a été décrit dans le contexte de différentes sous-populations d’un même type cellulaire. Les cellules dendritiques plasmacytoïdes (pDC) jouent un rôle clé lors des infections virales. Les pDCs ont la capacité de sécréter de grandes quantités d’interférons de type I et de se différencier en cellules dendritiques matures capables d’activer une réponse immunitaire adaptative. Il a été proposé que ces fonctions innées et adaptatives soient séquentiellement induites aprè

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3

Zunino, Barbara. "Dialogue entre le métabolisme et l’immunité dans le traitement des cancers." Thesis, Nice, 2014. http://www.theses.fr/2014NICE4113.

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Il est connu depuis de nombreuses années que le métabolisme des cellules cancéreuses diffère de celui des cellules saines. La Restriction Calorique (RC) est connue pour prolonger la durée de vie et pour limiter l’oncogenèse. Ainsi, il a été montré que la RC et ses mimétiques comme le 2-deoxyglucose (2DG) augmentent l’efficacité de la chimiothérapie et peuvent aussi induire une immunité anti-tumorale. J’ai pu montrer qu’en régulant le métabolisme via la restriction calorique (ou des mimétiques) nous pouvions moduler l’expression de la protéine anti-apoptotique Mcl-1. Ainsi nous avons établi in

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4

Champiat, Stéphane. "Caractérisation clinique et biologique de l’hyperprogression tumorale lors du blocage de la voie PD-1/PD-L1." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS040.

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Les anticorps bloquant les points de contrôle immunitaires modifient profondément la gestion des patients atteints de cancer. À la pointe de cette nouvelle classe d'agents anticancéreux, les anticorps anti-PD-1 / PD-L1 peuvent ainsi restaurer une réponse efficace des cellules T antitumorales. En conséquence, ces agents sont maintenant approuvés dans divers types de tumeurs, tels que le mélanome, le cancer bronchique non à petites cellules, le cancer du rein, les tumeurs ORL ou le cancer de la vessie. Ces nouvelles immunothérapies entraînent également de nouveaux profils de réponse tumorale tel

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5

Yates, Philip John. "Immunity to paramyxoviruses." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262218.

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6

Yang, Lili Rothenberg Ellen V. "Towards engineering immunity /." Diss., Pasadena, Calif. : California Institute of Technology, 2004. http://resolver.caltech.edu/CaltechETD:etd-06042004-000641.

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7

Zunino, Barbara. "Dialogue entre le métabolisme et l’immunité dans le traitement des cancers." Electronic Thesis or Diss., Nice, 2014. http://www.theses.fr/2014NICE4113.

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Il est connu depuis de nombreuses années que le métabolisme des cellules cancéreuses diffère de celui des cellules saines. La Restriction Calorique (RC) est connue pour prolonger la durée de vie et pour limiter l’oncogenèse. Ainsi, il a été montré que la RC et ses mimétiques comme le 2-deoxyglucose (2DG) augmentent l’efficacité de la chimiothérapie et peuvent aussi induire une immunité anti-tumorale. J’ai pu montrer qu’en régulant le métabolisme via la restriction calorique (ou des mimétiques) nous pouvions moduler l’expression de la protéine anti-apoptotique Mcl-1. Ainsi nous avons établi in

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8

Walker, Lee Charles. "Foreign State Immunity & Foreign Official Immunity: The Human Rights Dimension." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18198.

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This thesis concerns the attempt to establish human rights exceptions to foreign state immunity. The problem has multiple facets. Firstly, suits against foreign governments should be distinguished from suits against foreign officials. Further, in the latter context there is a distinction both between criminal and civil cases and between cases against individuals with immunity ratione personae and those with immunity ratione materiae. Individuals suffering extraterritorial jus cogens violations have been increasingly seeking justice against foreign governments and officials. Restrictive immunit

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9

Tadie, Jean Marc. "Rôles clinico-biologiques du monoxyde d'azote produit par les voies aériennes." Thesis, Paris Est, 2010. http://www.theses.fr/2010PEST0053/document.

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Le monoxyde d'azote (NO) est une molécule produite par l'ensemble des cellules des voies aériennes. Sa synthèse à partir de la L-arginine fait appel à un groupe d'enzymes : les NO synthases (NOS). Il existe trois isoformes de NOS exprimées par des cellules ayant des fonctions diverses conférant ainsi au NO produit une spécificité d'action dépendante de la cellule et de la « situation » ayant entraîné sa synthèse. Les travaux effectués dans le cadre de cette thèse explorent des rôles différents (bronchoréactivité, immunitaires) du NO produit par les voies aériennes ainsi que la mesure du NO dan

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10

Catozzi, Carlotta. "Water buffalo microbiota and immunity during infectious diseases." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670193.

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La tesi té com a objectiu investigar la resposta immune dels búfals d’aigua (Bubalus bubalis) durant malalties infeccioses (per exemple, mastitis, brucel·losi i tuberculosi) i malalties de produccions, com malalties metabòliques relacionades amb el peripart o l’estrès. Tenint en compte la relació entre l’entorn microbià i el sistema immunitari, també s’ha identificat el contingut de la microbiota de llet. El sistema immunitari del búfalo d’aigua ha estat poc caracteritzat fins ara, per no parlar de la microbiota, que era desconeguda. Els búfals d’aigua són sensibles a les mateixes malalties q

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11

Cherasse, Sarah. "Reproduction and immunity in ant queens: Reproduction et immunité chez les reines de fourmis." Doctoral thesis, Universite Libre de Bruxelles, 2019. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/284596.

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Ants and other social Hymenoptera (social bees and wasps) have a remarkable mating strategy. Social Hymenoptera live in societies where reproduction is monopolized by a fertile caste consisting of males and queens. On the other hand, the logistical tasks of the colony are carried out by a sterile female caste known as workers. Reproductive individuals mate during a single bout early in their life and will never engage in additional reproductive events later on. Males die soon after mating while queens store millions of sperm cells in a specialized organ, the spermatheca. Queens will use this s

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12

Mathewson, Donald Jeffrey. "Mathematical models of immunity." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29575.

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A cross-linking model for the activation of the A cell or immune accessory cell as a function of certain extracellular conditions is developed to determine the valency of the specific factor receptor on the A cell surface. It is found that such a determination can be made based on the FWHM of cross-linking curves which differ by a full order of magnitude between the bivalent receptor case and the monovalent receptor case. This determination can be made provided one can obtain accurate values for the equilibrium constants which characterize the system and provided that activation and IL-1 secre

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13

Storey, N. "Immunity to filarial nematodes." Thesis, University of Nottingham, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356035.

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14

Donnelly, P. K. "Protease and human immunity." Thesis, University of Newcastle Upon Tyne, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.371254.

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15

Bidgood, Susanna Ruth. "Antibody mediated intracellular immunity." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648288.

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16

Marks, Joanne. "Immunity to Neospora caninum." Thesis, University of Edinburgh, 1999. http://hdl.handle.net/1842/15265.

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This thesis covers three main areas of research. The first is a longitudinal sero-epidemiological study of a dairy herd which suffered an abortion storm linked to infection with <I>N. caninum</I> during August/September 1995. The main aims were to study the long term antibody response in cattle which have suffered <I>N. caninum</I> associated abortion, and to assess the rates of congenital infection, abortion and repeat abortion on the farm during the subsequent 3 year period. The second area of study investigated <I>Neospora</I> antigens recognised by <I>Neospora</I> antibody positive sera us

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17

West, Nicholas Peter. "Exercise, Immunity and Illness." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/367462.

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Identifying immune biomarkers in healthy humans that indicate an increased susceptibility to upper respiratory tract illness (URTI) is necessary to develop improved diagnostic and treatment strategies. URTI is associated with substantial socio-economic and personal cost. Small to moderate reductions in the severity and duration of illness could lead to substantial reductions in these costs. This thesis investigated the relationship between the immune system and URTI in healthy individuals utilising exercise as a model of stress. Chapter 2 (Section 2.2) reviews the effects of exercise on the im

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18

Appourchaux, Romain. "Caractérisation et conservation des mécanismes antiviraux des protéines IFITMs." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSEN046.

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IFITM1, 2 et 3 sont des protéines transmembranaires qui sont régulées à la hausse après stimulation interféron. Ces protéines sont capables d’inhiber un large spectre de virus. Le mécanisme d’action admis indique que la présence des IFITMs dans la membrane lipidique des cellules cibles diminue l’entrée des virus en bloquant la fusion de la membrane virale avec la membrane cellulaire.J’ai pris part en début de thèse à un travail qui a permis à notre équipe de mettre en évidence une deuxième configuration antivirale des protéines IFITMs contre le VIH-1 (Virus de l’Immunodéficience Humaine). En e

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19

Palgen, Jean-Louis. "Characterization of the innate immunity elicited by vaccination and its interactions with adaptive immunity, depending on prime-boost delay." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS146.

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La vaccination est l'un des plus grands progrès réalisés en santé publique. Toutefois, malgré de nombreuses connaissances sur le système immunitaire, de nombreux pans d’ombre empêchent la conception de vaccins contre des pathogènes complexes. Pour pallier ce problème, une meilleure compréhension des modes d'action des vaccins est requise. En particulier, la plupart des vaccins nécessitent plusieurs immunisations pour induire une mémoire immunitaire adaptative au long terme, mais l'impact du délai entre primo-vaccination, induisant une mémoire primaire, et rappel(s) la restimulant pour générer

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20

Suárez, González Orfeo. "La Inmunidad Olímpica La violación de derechos de los deportistas y la propuesta para la creación de un mecanismo jurídico de protección." Doctoral thesis, Universitat de Lleida, 2018. http://hdl.handle.net/10803/586254.

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Immunitat Olímpica és el nom donat al mecanisme de protecció dels drets dels esportistes que proposa aquesta tesi doctoral, sustentat jurídicament tant pels Principis Fonamentals de l'Olimpisme, especialment els supòsits de “no discriminació” recollits en la Carta Olímpica i en els estatuts de les federacions internacionals, com pels instruments del Dret Internacional que conformen la Carta Internacional dels Drets Humans. El treball demostra mitjançant l’exposició de casos com aquests drets han estat i són vulnerats, amb respostes desiguals per part de les organitzacions esportives i disparit

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21

Kenney, Laurie L. "The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/673.

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The dynamics of T cell responses have been extensively studied during single virus infection of naïve mice. During a viral infection, viral antigen is presented in the context of MHC class I molecules on the surface of infected cells. Activated CD8 T cells that recognized viral antigens mediate clearance of virus through lysis of these infected cells. We hypothesize that the balance between the replicating speed of the virus and the efficiency at which the T cell response clears the virus is key in determining the disease outcome of the host. Lower T cell efficiency and delayed viral clearance

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22

Kenney, Laurie L. "The Role of Heterologous Immunity in Viral Co-Infections and Neonatal Immunity: A Dissertation." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/673.

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The dynamics of T cell responses have been extensively studied during single virus infection of naïve mice. During a viral infection, viral antigen is presented in the context of MHC class I molecules on the surface of infected cells. Activated CD8 T cells that recognized viral antigens mediate clearance of virus through lysis of these infected cells. We hypothesize that the balance between the replicating speed of the virus and the efficiency at which the T cell response clears the virus is key in determining the disease outcome of the host. Lower T cell efficiency and delayed viral clearance

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23

Tjärnlund, Anna. "Mucosal Immunity in Mycobacterial infections." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6782.

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<p>More than a century after the identification of the tubercle bacillus and the first attempts at vaccination, tuberculosis (TB) still remains one of the world’s most serious infectious diseases. TB, caused by the bacterium <i>Mycobacterium tuberculosis</i>, is typically a disease of the lung, which serves both as port of entry and as the major site of disease manifestation. The currently used vaccine, BCG, is administered parenterally and induces a systemic immune response. However, it fails to protect against pulmonary TB, thereby raising the question whether vaccination targeting the mucos

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24

Shimokata, Kaoru. "Cytokines and Local Cellular Immunity." 名古屋大学医学部, 1997. http://hdl.handle.net/2237/6185.

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Rahman, Muhammad Jubayer. "Mucosal immunity against mycobacterial infection." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-39170.

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This thesis aimed to the identification of immune biomarkers of mycobacterial infection for better diagnosis of tuberculosis (TB) and also focused on new vaccination strategies with a particular emphasis on the immune responses in the respiratory tract using murine models. Since the lung is the natural habitat for the M. tuberculosis, we reasoned that immune responses detected locally in the lungs would be good correlates of infection (Paper I). Likewise, immune responses induced in the respiratory tract following immunization would be more effective against mycobacterial infection. We showed

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26

Yassine, Daadaa. "Network Decontamination with Temporal Immunity." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20633.

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Network decontamination is a well known mobile agent problem with many applications. We assume that all nodes of a network are contaminated (e.g., by a virus) and a set of agents is deployed to decontaminate them. An agent passing by a node decontaminates it, however a decontaminated node can be recontaminated if any of its neighbours is contaminated. In the vast literature a variety of models are considered and different assumptions are made on the power of the agents. In this thesis we study variation of the decontamination problem in mesh and tori topologies, under the assumption that when

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27

Chukwumerije, Okezie. "Sovereign immunity and transnational arbitration." Thesis, University of British Columbia, 1985. http://hdl.handle.net/2429/27350.

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State participation in the arbitration of transnational commercial disputes is steadily increasing. It is estimated that arbitration of state contract disputes presently constitute one quarter of the disputes submitted to ICC arbitration. Where a state party is involved in an arbitration, the sovereign immunity doctrine - which in some cases exempts foreign states from the jurisdiction of municipal courts - may have adverse effect on the arbitration process. The thesis explores the impact of the immunity doctrine on the arbitration of state contract disputes. State practice in selected jurisd

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28

Tjärnlund, Anna. "Mucosal Immunity in Mycobacterial infections /." Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm university, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6782.

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29

Elias, Daniel. "Helminths and immunity against tuberculosis /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7357-035-4/.

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30

Nohr, Carl William. "Humoral immunity in surgical patients." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=75969.

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Humoral immune function was studied in surgical patients. The antibody response to vaccination with a protein antigen, tetanus toxoid (TT), was reduced among all patients, especially those with reduced delayed type hypersensitivity (DTH) and increased degree of physiological derangement. The antibody response to a polysaccharide antigen, pneumococcal polysaccharide (PPS), was normal. In trauma patients, the antibody response to TT was normal. The in vitro production of specific and total immunoglobulin (Ig) by blood mononuclear cells was studied. Patients that failed to produce a serum antibod

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Argyriou, Catherine. "Enhanced immunity in Mclk1 +/- mice." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117161.

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MCLK1 (a.k.a. COQ7) is an evolutionarily conserved mitochondrial hydroxylase necessary ubiquinone biosynthesis. Mclk1+/- mice display a 50% reduction in this protein, as well as an array of phenotypes including increased longevity, decreased ubiquinone in the inner mitochondrial membrane, decreased mitochondrial respiration, and increased mitochondrial oxidative stress. We report here by various measures that Mclk1+/- mutants also exhibit an enhanced immune response in vivo. That is, Mclk1+/- mice mount a more extreme inflammatory response to bacterial lipopolysaccharide stimulation and bacter

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32

Arnaout, Ramy A. "Mathematical models of antiviral immunity." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325989.

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Permpoonpattana, Patima. "Clostridium difficile : infection and immunity." Thesis, Royal Holloway, University of London, 2013. http://repository.royalholloway.ac.uk/items/33009ec4-7815-0803-d39b-f968c8d9cdbb/7/.

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Clostridium difficile is a Gram positive pathogen of significant importance in the UK, Europe and the USA. No vaccine has been developed and current treatments are focused on hospital management and the use of antibiotics. The disease is spread in hospitals in the spore form and the role of spores in C. difficile infecton is poorly understood. In this project spores of C. difficile have been characterised. The proteins from the outermost layers of the spore were identified and the genes cloned. Three of these surface proteins have unique enzymatic properties that maybe important for symptoms o

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James, C. P. "Cervical antimicrobial immunity in pregnancy." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1471138/.

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Preterm birth (PTB) is a major problem in the UK and worldwide, leading to high mortality and significant long-term morbidity. A complex interaction between ascending genital tract infection and the maternal immune system is the likely underlying pathogenesis. We hypothesized that impaired cervical immunity leads to ascending infection and PTB i.e. women at high risk of PTB have a distinct cervical innate immune phenotype, which reflects genotypic variance. The systemic and mucosal expression and function of human beta defensins (HBDs), antimicrobial peptides with a range of immunomodulatory p

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Hewitt, Rachel Elaine. "Dietary microparticles and adaptive immunity." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607793.

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Halliday, Aileen. "Ruminant immunity to abomasal parasites." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8804.

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The studies submitted herein have contributed to our understanding of ruminant immunology, host-parasite interactions during ruminant infection with nematode parasites, and potential vaccine strategies to combat parasitic gastroenteritis (PGE). PGE of sheep and cattle, caused by T. circumcincta and O. ostertagia respectively, is a major problem for the global farming industry both in terms of productivity and animal welfare. To date control of these parasites has relied on the use of anthelmintic drugs however the emergence of widespread anthelmintic resistance is driving the search for altern

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37

Ahrens, S. "Extracellular actin in innate immunity." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1433762/.

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The innate immune system is capable of responding to tissue injury by detecting the abnormal exposure of intracellular, often ubiquitously expressed, molecules referred to as damage-associated molecular patterns (DAMPs). DAMPs are normally sequestered inside healthy cells but become exposed to the extracellular environment upon loss of membrane integrity during cell death. Exposed DAMPs are then recognised by receptors of the innate immune system. One such DAMP receptor is DNGR-1 (CLEC9A), which is expressed on CD8+ DCs, a rare but specialised subset of DCs involved in regulating T cell respon

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38

Atkinson, Cathie. "Defensive Coping, Stress, and Immunity /." The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487861396027367.

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Ali, K. S. M. "Immunity to Leishmania mexicana parasite." Thesis, Nottingham Trent University, 2014. http://irep.ntu.ac.uk/id/eprint/156/.

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Background: Cutaneous Leishmaniasis caused by the Leishmania mexicana complex is associated with unpleasant or disfiguring lesions, for which there only limited treatment options. The life cycle of L. mexicana consists of two stages which involve different immune evasion mechanisms: promastigote and amastigote. Understanding parasitic interactions with host cells and developing a protective vaccine could improve the management and treatment of the disease. Aims: • To construct and compare the immunogenicity of 3 Leishmania genes in 3 different plasmids. • Study the effect of long term in vitro

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40

Steele, John. "Molecular recognition in plant immunity." Thesis, University of East Anglia, 2016. https://ueaeprints.uea.ac.uk/58564/.

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Plant pathogens constitute a major threat to global food security. The use of naturally resistant crop varieties can limit crop losses, however new races of pathogen can arise that are able to overcome these defences. Plant breeding for race-specific resistance typically relies on disease-resistance genes, which generally encode proteins with nucleotide-binding and leucine-rich repeat domains (NB-LRRs). NB-LRRs are a large of proteins found in both plants and animals, with plant NB-LRRs further classified by the presence of N-terminal coiled-coil or toll-interleukin receptor domains. Although

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41

Karlsson, Jenny. "Peptidoglycan regulation of Drosophila immunity /." Stockholm : Department of Genetics, Microbiology and Toxicology, Stockholm University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29828.

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Diss. (sammanfattning) Stockholm : Stockholms universitet, 2009.<br>At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 2: Submitted. Härtill 4 uppsatser.

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Ramanathan, Balaji. "Innate immunity : receptors and effectors /." Search for this dissertation online, 2004. http://wwwlib.umi.com/cr/ksu/main.

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Neilson, Abbie Louise. "Lysosome morphology, exocytosis and immunity." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5067/.

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Many types of immune cells rely on secretory lysosomes to execute their function. These specialised organelles perform the catabolic function of conventional lysosomes and possess the added capacity to undergo regulated exocytosis. In particular, the cytotoxic function of natural killer (NK) cells depends on the rapid, polarised secretion of secretory lysosomes, known as lytic granules, for the targeted destruction of malignant and virally infected cells. Dysregulation of the biogenesis and exocytosis of secretory lysosomes is the cause of several severe immunological diseases such as Chédiak-

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Cubie, Heather A. "Human papillomavirus : pathogenesis and immunity." Thesis, University of Edinburgh, 1989. http://hdl.handle.net/1842/27846.

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The involvement of human papilloma virus (HPV) in the aetiology and progression of cervical intraepithelial neoplasia (CIN) is still unresolved. This study was designed to assess the immunological responses to HPV types in patients presenting with varying degrees of CIN and in control groups, using in vitro measures of cellular and humoral responses. Lymphocyte proliferation assays (LPA) were performed using peripheral blood mononuclear cells (PBM) and various papillomavirus (PV) antigens. Twenty -five per cent (23/92) of patients with CIN responded to antigens derived from purified BPV, HPV -

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Entwistle, Lewis James. "Novel mechanisms of antihelminth immunity." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10041378/.

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Intestinal helminths are highly prevalent worldwide, infecting approximately a third of the world’s population, causing significant host morbidity. With no current vaccines, a limited number of effective chemotherapeutic drugs available and the emergence of drug-resistant helminths, it is essential to further our understanding of the mechanisms of antihelminth immunity. Our current understanding of antihelminth immunity places the type 2 immune response at the forefront of protection, with type 2 cytokines orchestrating and activating a plethora of immune and non-immune cells to mediate parasi

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Palmer, Caroline V. "Biological mechanisms of coral immunity." Thesis, University of Newcastle Upon Tyne, 2010. https://researchonline.jcu.edu.au/32217/1/32217_Palmer_2010_thesis.pdf.

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Hard corals underpin the existence and biodiversity of tropical reefs, however they are declining globally at an alarming rate, largely because of increases in disease prevalence and thermal bleaching events. Despite extensive documentation of coral reef demise, no substantive investigations into the coral host's biological mechanisms for disease resistance, bleaching mitigation or wound healing have been conducted. Coral immunology may therefore provide important insights into understanding the capacity of corals to resist global coral declines. The principal objectives of this thesis were th

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Palmer, Caroline V. "Biological mechanisms of coral immunity." Thesis, University of Newcastle Upon Tyne, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.544191.

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AVILA, MORALES GABRIELA DE LOS ANGELES. "NUTRITION AND IMMUNITY: MOLECULAR APPROACHES." Doctoral thesis, Università degli Studi di Milano, 2022. https://hdl.handle.net/2434/952952.

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Nutrition plays an important role in modulating livestock species immunity. Therefore, this thesis aimed at evaluating the effects of different dietary molecules used in animal nutrition on mammalian and avian immunity. Both, in vitro functional analyses and OMIC technologies (proteomics and miRNAomics) were implemented herein for an integral characterization of the molecules’ impact on the animals’ immune response. Specifically, in this thesis the in vitro impact of the n-6 conjugated linoleic acid (CLA), citrus pectin (CP), and porcine milk exosomes and n-3 polyunsaturated fatty acids (PUFA)

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They, Laetitia. "Renforcement des effets immunomodulateurs d’un anticorps monoclonal anti-tumoral : étude des effets potentialisateurs de thérapies combinées et analyse des mécanismes impliqués." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTT076/document.

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Le mélanome est la forme la plus agressive des cancers de la peau. Si sa prise en charge à des stades précoces est de bon pronostic, l’espérance de vie des patients chute dramatiquement pour les stades métastatiques. Malgré les avancées thérapeutiques spectaculaires récentes, le problème majeur réside dans la résistance aux traitements et la récidive et le défi principal est désormais de tendre vers un contrôle efficace et durable. Les anticorps monoclonaux (AcM) ont la capacité de cibler et éliminer spécifiquement la cellule tumorale tout en recrutant des cellules du système immunitaire, perm

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Gebauer, Christina. "The Janus face of immunity : how anti-tumor immunity leads to autoimmunity in paraneoplastic neurological diseases." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30139/document.

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Les syndromes neurologiques paranéoplasiques (SNP) sont des maladies neurologiques rares, associés à une réponse immunitaire efficace contre un cancer sous-jacent exprimant un antigène également exprimé par des cellules du système nerveux central (SNC). Le cancer déclenche alors une réponse auto-immune secondaire qui provoque la destruction des cellules du SNC. Certains travaux récents suggèrent que l'immunité à médiation cellulaire associée à des auto-anticorps reconnaissant des antigènes intracellulaires pourrait jouer un rôle majeur, bien qu'encore mal compris, dans la physiopathologie des

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