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Rozprawy doktorskie na temat „Immunoglobulin A”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Das, Mrinmoy. "The regulatory effects of circulating normal immunoglobulins on autophagy and Th17 response." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066153/document.

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Les immunoglobulines circulantes jouent un rôle critique dans l’homéostasie immune en modulant les fonctions des cellules du système immunitaire. Au cours de ma thèse, j’ai exploré les effets régulateurs des immunoglobulines G thérapeutiques (IVIG) et des immunoglobulines A monomériques circulantes (mIgA) sur l’autophagie et les réponses Th17 respectivement. Les IVIg sont une préparation thérapeutique d’IgG normales poolées. Elles ont utilisées comme agent anti-inflammatoire dans le traitement de maladies auto-immunes et inflammatoires variées. Cependant, les mécanismes ne sont pas complètemen

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2

Martinez-Rivas, Gemma. "Exploration des mécanismes physiopathologiques de l'amylose et évaluation des nouvelles approches thérapeutiques." Electronic Thesis or Diss., Limoges, 2024. http://www.theses.fr/2024LIMO0052.

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L’amylose à chaînes légères (AL) est l’une des formes les plus courantes d’amylose systémique, provoquée par le dépôt de chaînes légères (LC) d’immunoglobulines (Ig) sous forme de fibrilles amyloïdes dans les tissus, entraînant une dysfonction organique. Les formes les plus fréquentes et sévères affectent les reins et le cœur, cette dernière étant associée à un mauvais pronostic. Malgré des efforts considérables pour comprendre les mécanismes de formation des fibrilles et leur toxicité, l’absence de modèles in vivo fiables entrave l’étude de la maladie dans son contexte physiologique. Cette th

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3

Carpenet, Guéry Hélène. "Radiomarquage au 99mTc des IgA et IgG : optimisation du marquage, étude in vitro, biodistribution chez l'animal sain et sur modèle tumoral." Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0074/document.

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Depuis leur découverte en 1975 par Köhler et Milstein, le monde des Ac monoclonaux a beaucoup évolué. Ils occupent actuellement une place prépondérante dans la prise en charge de nombreux cancers. De nos jours, les Ac monoclonaux, ayant une AMM ou en essai clinique, sont tous de classe IgG voire IgG1. Cette classe d’Ac a cependant montré des limites à son utilisation, et l’étude d’autres isotypes d’Ac, comme les IgA, pourrait être intéressante. Les IgA, isotype d’Ac particulier en raison notamment de leur hétérogénéité dans les formes moléculaires, demeurent peu étudiées à l’instar des IgG. Da

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4

Hirano, Ayumi. "T dependent B cell help in cattle : immunoregulatory function of interleukin-4 and CD40-CD40L interactions /." free to MU campus, to others for purchase, 1997. http://wwwlib.umi.com/cr/mo/fullcit?p9841150.

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5

Almroth, Gabriel. "Immunoglobulins, immunoglobulin subclass-distributions and serologic markers in some renal and systemic disorders /." Linköping : Univ, 2000. http://www.bibl.liu.se/liupubl/disp/disp2000/med646s.pdf.

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6

Rogers, Kenneth Alton. "Immunoglobulins and Immunoglobulin Fc Receptors in Nonhuman Primates Commonly Used in Biomedical Research." Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/biology_diss/6.

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Antibodies neutralize and eliminate pathogens, malignancies, and toxins by acting either alone or in association with Fc receptors which, once engaged, activate the elimination mechanisms of phagocytic cells. Based on structural differences, antibodies are divided into functionally distinct classes (IgM, IgD, IgG, IgE and IgA). Structure-function relationships within these classes are not well characterized. In addition, animal models for the assessment of potential therapeutic strategies for the modulation of the interaction between antibodies and Fc receptors are not established. Nonhuman pr

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7

Ding, Cheng. "Siglec-G is a negative regulator of NF-[kappa]B activation and has pivotal roles in B-1 cell development and resistance to sepsis /." Columbus, Ohio : Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1226876722.

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8

Laurencikiene, Jurga. "Regulation of germline transcription in the immunoglobulin heavy chain locus /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-989-7/.

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9

Couston, Ruairidh Gair. "Characterising immunoglobulin-polysorbate interactions." Thesis, University of Strathclyde, 2013. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=18963.

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Therapeutic proteins, such as immunoglobulins, are typically formulated with polysorbates as stabilisers. However, the nature of the immunoglobulin-polysorbate interaction, particularly at the solid-liquid interface, is poorly characterised. This thesis presents an investigation of immunoglobulin (mAb-1)-surfactant interaction in bulk solution with particular focus on the interaction at the solid-liquid interface. It was first established using isothermal titration calorimetry that no specific binding interaction between mAb-1 and surfactant in solution takes place. Furthermore, circular dichr

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10

Pouria, Shideh. "A study of immunoglobulin A biology in primary and hepatic immunoglobulin A nephropathy." Thesis, King's College London (University of London), 2005. https://kclpure.kcl.ac.uk/portal/en/theses/a-study-of-immunoglobulin-a-biology-in-primary-and-hepatic-immunoglobulin-a-nephropathy(e31804ca-526c-49d0-8767-9110d84f7a4b).html.

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11

Mason, J. O. "Regulation of immunoglobulin gene expression." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384506.

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12

Hunt, James. "Structural studies of immunoglobulin E." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/structural-studies-of-immunoglobulin-e(251aec27-5e3a-4ce5-9fbe-9493d158129d).html.

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13

Wang, Hui. "Immunoglobulin binding proteins in ticks." Thesis, University of Oxford, 1995. http://ora.ox.ac.uk/objects/uuid:7c09068b-82fb-4434-9e84-4663cbab7795.

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14

Sukumaran, Muralidharan. "Optical sensors for immunoglobulin G." Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.620564.

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15

Doré, Katy Alison. "The evolution of immunoglobulin E." Thesis, King's College London (University of London), 2015. https://kclpure.kcl.ac.uk/portal/en/theses/the-evolution-of-immunoglobulin-e(4c611aa6-eed9-4abb-81f7-b9afe97e78bb).html.

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Allergic asthma is a type I hypersensitivity reaction, mediated by IgE. Severe asthma is inadequately treated with existing medicines. A greater understanding of IgE structure and function, and how it relates to its receptors,FcεRI and CD23, is required to improve therapeutic intervention. An evolutionary approach has been used to further this understanding, with the investigation of three proteins that are evolutionarily related to human IgE: platypus IgE, chicken IgY and human IgM. The sequences of these proteins were compared and constructs were designed that contained different fragments o

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16

Habich, Hans. "Immunoglobulin therapy in ophthalmic diseases /." [S.l : s.n.], 1986. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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17

Koch, Urs Daniel. "Immunoglobulin therapy for herpes zoster /." [S.l.] : [s.n.], 1985. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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18

Searle, Stephen M. J. "Molecular modelling of immunoglobulin folds." Thesis, University of Bath, 1997. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246005.

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19

Didriksen, Nancy A. (Nancy Andrews). "Psychological Stress: Effect on Humoral Immune Functioning as Measured by Immunoglobulin Levels." Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331278/.

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The purpose of the present study was to determine if psychological stress, defined as academic examination stress, would systematically produce changes in immune parameters (immunoglobulin concentration) and psychological functioning. It was hypothesized that as examination stress occurred there would be an effect on immunological function consistent with heightened psychological activity/stress. Subjects were 23 master's and doctoral students in psychology who volunteered for the research project. All subjects were administered a series of psychological tests to measure stress, personality fa

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20

Sellers, Lisa K. "Exercise-induced alterations in immunoglobulin (IgA, IgG, IgM) levels in cancer versus non-cancer patients." Muncie, Ind. : Ball State University, 2008. http://cardinalscholar.bsu.edu/384.

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21

Pratt, Stephanie Ann. "Immunoglobulin A1 protease of Streptococcus pneumoniae." Thesis, University of Leicester, 1988. http://hdl.handle.net/2381/35410.

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The aim of this project was to examine the Streptococcal IgA1 proteases, with particular interest on the Streptococcus pneumoniae enzyme. IgA1 protease of S. pneumoniae was identified and characterised. A non-reducing polyacrylamide gel system was employed to screen clinical isolates for IgA1 protease activity. Of 187 isolates tested 18% were found to be IgA1 protease negative, there was no correlation with the site of isolation of the organism and its ability to produce the enzyme. Attempts were made to clone the pneumococcal IgA1 protease gene using the cosmid pEMBLcos4, the plasmid vector p

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22

Yip, Bon-ham. "Immunoglobulin gene translocations in gastric lymphoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37345321.

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23

Corbett, S. J. "The human immunoglobulin diversity segment repertoire." Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597991.

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Combination recombination of Variable (V), Diversity (D) and Joining (J) immunoglobulin gene segments with imprecise loss and gain of nucleotides at segment joins creates a diverse primary antibody repertoire. In humans it has also been proposed that utilisation of DIR segments, multiple D segments and inverted D segments increases diversity further. However to date, incomplete knowledge of the germline D segment repertoire has made it difficult to dissect out the precise mechanisms involved. This thesis describes the complete nucleotide sequence of the functional human D segment locus on chro

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24

Yip, Bon-ham, and 葉邦瀚. "Immunoglobulin gene translocations in gastric lymphoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37345321.

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25

Watson, Nigel. "Monoclonal antibodies to human immunoglobulin allotypes." Thesis, University of Strathclyde, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.304897.

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26

Tomlinson, Ian Michael. "The human immunoglobulin Vâ†H repertoire." Thesis, Open University, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295301.

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27

Sale, Julian Edward. "Constitutive immunoglobulin gene hypermutation in vitro." Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624417.

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28

Carrera, J. P., Zulma M. Cucunuba, Karen Neira, et al. "Endemic and epidemic human alphavirus infections in eastern Panama: An analysis of population-based cross-sectional surveys." American Society of Tropical Medicine and Hygiene, 2020. http://hdl.handle.net/10757/655503.

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Madariaga virus (MADV) has recently been associated with severe human disease in Panama, where the closely related Venezuelan equine encephalitis virus (VEEV) also circulates. In June 2017, a fatal MADV infection was confirmed in a community of Darien Province. We conducted a cross-sectional outbreak investigation with human and mosquito collections in July 2017, where sera were tested for alphavirus antibodies and viral RNA. In addition, by applying a catalytic, force-of-infection (FOI) statistical model to two serosurveys from Darien Province in 2012 and 2017, we investigated whether endemic

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29

Roberts-Thomson, Peter John. "Low molecular weight IgM in health and disease /." Title page, index and abstract only, 1987. http://web4.library.adelaide.edu.au/theses/09MD/09mdr648.pdf.

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30

Lohman, Isabelle Carlotta 1948. "THE PRODUCTION AND PURIFICATION OF RABBIT SERUM IMMUNOGLOBULIN-E, AND THE ROLE OF IMMUNOGLOBULIN-E IN SYSTEMIC ANAPHYLAXIS." Thesis, The University of Arizona, 1987. http://hdl.handle.net/10150/291183.

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31

Schiavo, Ebe. "Molecular mechanisms controlling immunoglobulin class switch recombination." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ084/document.

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Lors des réponses immunitaires, le répertoire des lymphocytes B est diversifié par l’hypermutation somatique (HMS) et la commutation isotypique (CI), dépendant d’«activation-induced cytidine deaminase» (AID), qui introduit des lésions dans les gènes Ig. Une déficience d’AID cause un défaut d’HMS et de CI; par contre, une délétion du domaine C-terminal d’AID cause un défaut spécifique de la CI, suggérant que ce domaine interagit avec des facteurs spécifiques de la CI. Pour identifier ces facteurs, nous avons étudié une immunodéficience présentant un défaut de la CI non lié à la carence d’AID ni

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32

Ordinario, Ellen. "Dynamics and mechanism of immunoglobulin gene diversification /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9266.

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33

Field, Helen. "On production of recombinant immunoglobulin variable domains." Thesis, University of Oxford, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330288.

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34

de, Bono B. "Immunoglobulin superfamily proteins in human and mouse." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.598443.

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Automated gene-prediction procedures have a number of shortcomings, and a method has been developed to address some of these. My approach drew upon the ability of hidden Markov models to detect distantly-matching patterns of IgSF sequences at both transcript and genomic DNA level. Ensembl gene predictions were used to locate the majority of human and mouse genes, but my method also detected IgSF genes just out of reach of standard pairwise techniques, resulting in a significantly improved coverage of IgSF genome coding sites. The experimental characterisation of two novel non-classical MHC mou

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35

George, Laura. "Regulation of extrafollicular immunoglobulin class switch recombination." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5109/.

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The humoral immune response is characterised by the production of antibody secreting B cells. Some of these cells have cycled through the germinal centre, diversifying and optimising their antigen receptors to produce affinity-matured, class switched antibody. As this is a relatively slow process, the first class switched antibody is produced by non-mutated B blasts that have differentiated independently of the germinal centre reaction outside B-cell follicles. Extrafollicular foci of plasmablasts provide the first line of defence within the adaptive antibody response. IRF4 has been shown to b

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36

Wright, Caroline Fiona. "Folding and aggregation of an immunoglobulin domain." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616276.

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37

Fraser, Louise. "Immunoglobulin light chains in Systemic Lupus Erythematosus." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/immunoglobulin-light-chains-in-systemic-lupus-erythematosus(759b46c1-24bc-427d-8b25-8987eec6f61f).html.

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Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease of elusive origin and characterised by polyclonal B cell hyperactivity and the production of pathogenic antibodies targeting self DNA and nucleoproteins. Clinical manifestations of SLE are highly heterogeneous and include multisystem inflammation of connective tissue and vasculitis of the central nervous system (CNS). SLE is known to have genetic associations, and is widely acknowledged to involve a profound breakdown in immune tolerance. The aim of this project was to identify whether defects in early B cell development that a

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38

Farley, Carol J. "Stress, appraised control, and salivary immunoglobulin A." Thesis, Anglia Ruskin University, 2010. http://arro.anglia.ac.uk/188989/.

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Salivary IgA is the primary antibody of mucosal immunity. It has been suggested that chronic stress may lower levels of IgA and lead to an increased susceptibility to respiratory illness. It is also suggested that acute stress increases IgA during active coping (that involves mental effort or controllability, such as time-based mathematics or memory tests) and decreases it during passive coping tasks (with no mental effort required or uncontrollable, such as the passive viewing of disgust images). However, tasks often classed as stressors have produced consistent IgA effects in areas of passiv

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39

Farley, Carol J. "Stress, appraised control, and salivary immunoglobulin A." Thesis, Anglia Ruskin University, 2010. https://arro.anglia.ac.uk/id/eprint/188989/1/Thesis_Farley_2010.pdf.

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Salivary IgA is the primary antibody of mucosal immunity. It has been suggested that chronic stress may lower levels of IgA and lead to an increased susceptibility to respiratory illness. It is also suggested that acute stress increases IgA during active coping (that involves mental effort or controllability, such as time-based mathematics or memory tests) and decreases it during passive coping tasks (with no mental effort required or uncontrollable, such as the passive viewing of disgust images). However, tasks often classed as stressors have produced consistent IgA effects in areas of passiv

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40

Dixon, Emma Victoria. "Mechanisms of immunoglobulin deactivation by Streptococcus pyogenes." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:ec80e3f9-0c73-4d39-bc68-c39b927365d4.

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The bacteria Streptococcus pyogenes produces a multitude of proteins which interact with and alter the functions of the host immune system. Two such proteins, Endoglycosidase S (EndoS) and Immunoglobulin G-degrading enzyme from S. pyogenes (IdeS) are able to specifically alter the effector functions of immunoglobulin G (IgG). EndoS is a glycoside hydrolase which removes the conserved <i>N</i>-linked glycan from IgG Fc whereas IdeS is a cysteine protease that cleaves the exible protein hinge of IgG. The activity of both proteins results in the reduced ability of IgG to elicit immune responses t

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41

Chintalacharuvu, Koteswara Rao. "Disulfide bond formation between dimeric immunoglobulin A and the polymeric immunoglobulin receptor in cultured epithelial cells and rat liver." Case Western Reserve University School of Graduate Studies / OhioLINK, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=case1055268413.

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42

Borthakur, Susmita. "Structural flexibility and immunoglobulin constant domains : role of the intrinsic flexibility of the C&3 domain of immunoglobulin E." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531955.

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43

Bartholomeuz, Risien Chiron Andrew. "Polymeric IgA antibody in humans after vaccination and in disease /." Title page, contents and abstract only, 1989. http://web4.library.adelaide.edu.au/theses/09MD/09mdb287.pdf.

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44

Johansson, Karin. "Analysis of immunoglobulin gene expression focus on Oct2 /." Lund : Dept. of Cell and Molecular Biology, Lund University, 1995. http://catalog.hathitrust.org/api/volumes/oclc/39776663.html.

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45

Heidari, Ramesh. "Immunoglobulin VH gen analys in human B-cell." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7392.

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<p>Malt lymphoma is a malignant disease that can arise in a variety of extra nodal sites. Previous studies indicate that tumour arise from more mature B-cells.</p><p>Our purpose was to examine the presence of clonality and somatic hypermutation of immunoglobulin (IgVн) of MALT lymphomas.</p><p>Paraffin-embedded tumour samples from13 MALT lymphoma were subjected to rearrangement analysis, by using PCR, heteroduplex gels and sequence analysis.</p><p>Successful amplification was seen in 10/13 cases and sequences of IgVн genes were obtained in 6/13, all of them were mutated. The percentage of muta

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46

Oancea, Adriana Ecaterina. "Immunoglobulin heavy chain gene expression in hybridoma cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0010/NQ28030.pdf.

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47

Andersson, Tove. "Transcription factors regulating the immunoglobulin heavy chain locus /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3559-9/.

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48

Betz, Alexander Guido. "Somatic hypermutation of immunoglobulin #KAPPA# light chain genes." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319561.

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49

Duncan, Alexander Robert. "The location of effector sites in immunoglobulin IgG." Thesis, University of Cambridge, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.238535.

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50

Preston, Alexandra McEwan. "Interactions of immunoglobulin superfamily leukocyte cell surface molecules." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318630.

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