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Rozprawy doktorskie na temat „Immunohistochemistry”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

King, George. "Studies of amplification methods in immunohistochemistry." Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU537963.

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The aim of this project was to compare and contrast the results of three related methodologies which are of particular relevance or potential within our department -. a manually performed streptAvidin Biotin Complex (sABC/ HRP) method which for many years has served as our 'standard' immunocytochemical method; an integrated semi-automated systems from DAKO based on the TechMate 500 immunostainer and the ChemMate reagent package;. a manually performed tyramide amplification method regarded as amongst the most sensitive immunocytochemical method currently available. Antigen retrieval investigati

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2

Lam, Sing-chi, and 藍承志. "A HRCT and immunohistochemistry study on bronchiectasis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30402499.

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3

Shu, Jie. "Immunohistochemistry image analysis : protein, nuclei and gland." Thesis, University of Nottingham, 2014. http://eprints.nottingham.ac.uk/27616/.

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This thesis focus on the analysis of digitized microscopic image, especially on IHC stained colour images. The corresponding contributions focused on the automatic detection of stain colour and glands, the segmentation and quantification of cell nuclei, the analysis of liver cirrhosis and the development of a semi-automatic toolbox. Colour is the most important feature in the analysis of immunostained images. We developed a statistical colour detection model for stain colour detection based on the histograms of collected colour pixels. This is acting on the approach "what you see is what you g

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4

Koria, Muntaha. "Identification of PHPT1 in mouse tissues by immunohistochemistry." Thesis, Uppsala University, Department of Medical Biochemistry and Microbiology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7745.

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<p>Although it has been estimated that protein histidine phosphorylation account for about 6 % of the protein phosphorylation in eukaryotic cells; the knowledge of histidine phosphorylation and dephosphorylation is still limited. Lately, studies have appeared of a mammalian 14-kDa phospho- histidine phosphatase, also named protein histidine phosphatase and molecular cloning have provided some information of its physiological role. The object of the present study was to detect the protein expression of protein histidine phosphatase, PHPT1, in mouse tissue, by using immunohistochemistry. Tissue

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5

Sundara, Rajan Sreekumar. "Investigating male breast cancer using transcriptomics and immunohistochemistry." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/15847/.

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Background: The rare nature of male breast cancer (MBC) has led to its management being guided by the extensive research conducted in the field of female breast cancer (FBC). The aim of this study was to evaluate MBC at both protein and molecular level to improve understanding of its pathology. Methodology: Immunohistochemistry analysis was performed in MBC (n=428) TMAs for 18 biomarkers (ERα, ERβ1, ERβ2, ERβ5, Total PR, AR, CK5/6, CK14, CK18, CK19, p53, Bcl-2, Her2, E-cadherin, Ki67, Survivin, Prolactin and FOXA1). The manual scoring of ERα and Ki67 was correlated with a fully automated immun

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6

Café, Marçal Valéria. "Pathology and immunohistochemistry of Cheetah (Acinonyx jubatus) myelopathy /." [S.l.] : [s.n.], 2006. http://www.stub.ch/index.php?p=1&i=645.

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7

Rozell, Björn. "Immunohistochemical studies of the thioredoxin system." Göteborg : Dept. of Histology, University of Göteborg, 1987. http://catalog.hathitrust.org/api/volumes/oclc/17242526.html.

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8

Kolivras, Athanassios. "Immunohistochemistry in the histopathological diagnosis of primary scalp alopecia." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/238160.

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Primary scalp alopecia is classically divided into cicatricial (scarring) and non-cicatricial (non-scarring). Challenging cases are assessed with a scalp biopsy. The use of both horizontal and vertical sections (HoVert sections) has dramatically improved the accuracy of histopathological diagnosis. In this work, we have used immunostaining to address diagnostic difficulties, which persist despite all currently available tools. We performed an immunostain panel (CD3, CD4, CD8 and CD20) in order to distinguish pattern hair loss from alopecia aerate in cases which do not have the usual peribulbar

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9

Holtzhausen, Wendy. "Diuretic factors controlling beetle malphighian tubules fluid secretion and immunohistochemistry /." Pretoria : [s.n.], 2006. http://upetd.up.ac.za/thesis/available/etd-07182007-164904.

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10

Fung, Hau-yin Kevin. "Detection of SARS-CoV in lung tissues by immunohistochemistry and in-situ hybridization /." View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32020624.

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11

Fung, Hau-yin Kevin, and 馮孝賢. "Detection of SARS-CoV in lung tissues by immunohistochemistry and in-situ hybridization." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B45010018.

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12

De, Silva Roxanne. "The use of collagen IV immunohistochemistry in the diagnosis of bullous pemphigoid." Master's thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/25249.

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Background: Autoimmune bullous dermatoses present with overlapping clinical features that require histopathological correlation. Immunofluorescence is the most routinely used reliable investigation for diagnosis but requires specialised equipment and is technically sophisticated. Collagen IV immunohistochemistry is reported as a reliable test for the diagnosis of epidermolysis bullosa acquisita whereby It stains the roof of a subepidermal blister and would be expected on the floor in bullous pemphigoid. This technique could be performed as an easily accessible alternative to direct immunofluor

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13

Lu, Junjie. "EVALUATION OF THE WOUND HEALING PROCESS BY IMMUNOHISTOCHEMISTRY AND PICROSIRIUS RED STAINING." Master's thesis, Temple University Libraries, 2017. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/437369.

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Bioengineering<br>M.S.<br>Non-healing wounds, also known as chronic wounds, are defined as wounds that do not show improvement in healing within four weeks. Chronic wounds affect millions of people around the world and health care expenses in the United States can cost more than one billion dollars. Chronic wound healing is a complicated process with different pathologies depending on the patients’ condition. Four highly integrated and overlapping phases compose the wound healing process: hemostasis, inflammation, proliferation, and tissue remodeling. Occurrence of chronic wounds is usually du

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14

Qureshi, Khaver Naseer. "The clinical significance and analysis of DNA microsatellites and TP53 associated changes in bladder cancer." Thesis, University of Newcastle upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247848.

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15

Woolley, Marie. "The functional role of the 5-htâ‚† receptor in the rat CNS." Thesis, University of Nottingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250592.

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16

McIntosh, Gary Gordon. "Evaluation of the clinical and biological significance of overexpression of... genes at the int-2/hst-1 oncogene amplification locus on band q13 of chromosome 11 in human breast cancer." Thesis, University of Newcastle Upon Tyne, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321591.

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17

Simpson, David John. "Methylation of the tumour suppressor genes p16 and RB1 and their role in the tumorigenesis of sporadic pituitary adenomas." Thesis, Keele University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.344058.

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18

Ashton-Key, Margaret Rose. "New approaches to the diagnosis of malignant lymphomas." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242743.

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19

Ashworth, Jonathan F. "Immunohistochemical study of marmoset periodontal ligament microvasculature : a confocal laser scanning microscopic study." Title page, contents and summary only, 1999. http://web4.library.adelaide.edu.au/theses/09DM/09dma831.pdf.

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20

Campbell, Ian Christopher. "Plaque erosion and murine plaque stability: a biomechanical examination of exceptions to the phenomenon of plaque rupture." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/47741.

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Atherosclerotic plaque disruption leading to thrombosis has traditionally been studied as a rupture of a thin fibrous cap over a lipid-laden necrotic core. However, two noteworthy categories of plaques that do not rupture have presented themselves: 1) in mice, plaque rupture is rare if not absent, and 2) in humans, some plaques erode and form a thrombus without rupturing. Current understanding of the biomechanical differences between plaques that rupture and those that do not is incomplete. In this research, we used patient-specific computational biomechanics tools to study differences among t

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21

Bennett, Peter. "Intrinsic Connectivity of the Claustrum : Gap Junctions Demonstrated by Immunohistochemistry and Electron Microscopy." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for nevromedisin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-26190.

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The claustrum is a much neglected nucleus in the brain, whose fuction remains unknown to date. Yet, based on the extensive reciprocal connections it shares with virtually all functional regions of cortex, it most likely serves a far from meaningless purpose. Current hypotheses propose a role in perceptual binding by synchronization of cortical activity. These hypotheses come with a number of assumptions, such as a wide network of connections intrinsic to the claustrum. In this context, gap junctions have been suggested as a means to interconnect portions of the claustrim and to synchronize inc

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22

El-Tarhouni, Amal Ibrahium. "Studies on the mechanosensory innervation of muscle using organotypic culture, reinnervation and immunohistochemistry." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5266/.

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This thesis studies sensory innervation in mammals using an organotypic co-culture of spinal cord-dorsal root ganglion and skeletal muscle of embryonic rat, the histological changes of reinnervated muscle spindles after nerve section and the localisation of the calcium-binding protein calretinin in cat mechanoreceptor organs. The immediate importance of this project concerns the better understanding of how the normal process of development differs from reinnervation following nerve lesion or section. A range of classical and well defined materials and methods as been used in the work described

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23

Grant, John William. "Immunohistochemistry in the diagnosis and characterisation of neoplasms affecting the central nervous system." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.278778.

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This work describes 5 groups of tumours seen in routine neuropathological practice in Southampton between 1980 and 1986. The clinical and light microscopic findings in a total of 44 tumours are described. A panel of monoclonal and polyclonal antibodies was used in immunohistochemical studies on each group, and this made important contributions to the diagnosis and characterisation of these tumours. Six primary central nervous system lymphomas were shown to be 5 follicle centre cell lymphomas (Kiel-classification) and 1 T-cell lymphoma. 15 lymphomas causing spinal cord compression were typed as

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24

Soldin, Ryan Peter. "Oesophageal squamous cell carcinogenesis : a study of cell cycle regulatory proteins by immunohistochemistry." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/25802.

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Oesophageal squamous cell carcinoma (OSCC) is a highly malignant tumour that has a poor prognosis and shows marked regional variation in its incidence, implicating environmental factors. South Africa is one of several countries that has areas of high incidence. The exact aetiopathogenesis of OSCC is not well understood. Current environmental risk factors include alcohol, tobacco, human papillomavirus (HPV) infection and nutritional factors including; low intake of Vitamins A, C and riboflavin, lack of fruit and vegetables, ingestion of fungal contaminated foods and consumption of extremely hot

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25

Foster, Cheryl June. "Identifying a prognostic test in follicular lymphoma using a tissue microarray and immunohistochemistry." Thesis, Kingston, Ont. : [s.n.], 2008. http://hdl.handle.net/1974/1296.

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26

Paavilainen, Linda. "Validation of antibodies for protein profiling A study using immunohistochemistry on tissue microarrays /." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107471.

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27

Andrici, Juliana. "Tissue biomarkers detected by immunohistochemistry as diagnostic and prognostic indicators in human malignancies." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16721.

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Immunohistochemistry involves the use of labelled antobodies to detect and visualise the presence of selected antigens. It is widely used in the doagnosis of cancers in which specific antigens are either up-regulated or absent.«br /» We are studying newly-discovered biomarkers such as BAP1, and are suggesting novel uses for them in the diagnosis of cancers such as malignant mesothelioma, cholangiocarcinoma, and gynecological malignancies.«br /» We are also examining the role of microsatellite instability in the diagnosis of colorectal cancer and adrenocortical cancer.

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28

Zahrani, Ahmed Abdulrahim. "Cell cycle associated markers in oral cancer and precancer." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297573.

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29

Hao, Xingpei. "Sporadic colorectal carcinogenesis : an evaluation of cell proliferation, apoptosis and adhesion molecules." Thesis, University of Westminster, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263924.

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30

Phelps, Monika. "The significance of abnormalities of P53 expression in lymphoma associated with coeliac disease." Thesis, University of Southampton, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342660.

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31

Zhang, Li Ping. "Investigations of C-FOS expression in rat spinal cord in vitro." Thesis, University of Southampton, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242708.

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32

Martinez, Mata Guillermo. "Avaliação do perfil de citoqueratinas e marcadores de proliferação celular em lesões odontogenicas : queratocisto odontogenico, cisto odontogenico ortoqueratinizado e fibroma odontogenico central." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288366.

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Orientador: Oslei Paes de Almeida<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-11T22:55:27Z (GMT). No. of bitstreams: 1 MartinezMata_Guillermo_D.pdf: 5085284 bytes, checksum: 173edda03dc15aa9efb05b262cd34e77 (MD5) Previous issue date: 2007<br>Resumo: A região bucomaxilofacial é freqüentemente afetada por lesões císticas e tumorais que apresentam características clínicas e histológicas heterogêneas cuja origem está associada a diversos estágios da odontogênese. Entre as lesões císticas mais freqüentes, t

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33

Soares, Maria de Jesus Veloso. "Sequenciamento de DNA e imunoistoquímica renal para detecção de Leishmania sp em cães /." Jaboticabal : [s.n.], 2007. http://hdl.handle.net/11449/104642.

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Orientador: Julieta Rodini Engracia de Moraes<br>Banca: Ana Maria Ferreira Roselino<br>Banca: Angela Cleusa de Fatima Banzatto de Carvalho<br>Banca: Carlos Noriyuki Kaneto<br>Banca: Gilson Pereira de Oliveira<br>Resumo: A leishmaniose é uma enfermidade provocada por protozoários do gênero Leishmania, que pode produzir manifestações cutâneas, mucocutâneas ou viscerais. Os objetivos deste ensaio foram os de identificar a espécie Leishmania (Leishmania) chagasi, utilizando o método PCR-RFLP em amostras de tecido de cães com leishmaniose visceral; seqüenciar o fragmento amplificado de DNA das amos

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34

Agnarsdóttir, Margrét. "Biomarker Discovery in Cutaneous Malignant Melanoma : A Study Based on Tissue Microarrays and Immunohistochemistry." Doctoral thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-146436.

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The incidence of cutaneous malignant melanoma has increased dramatically in Caucasians the last few decades, an increase that is partly explained by altered sun exposure habits. For the individual patient, with a localized disease, the tumor thickness of the excised lesion is the most important prognostic factor. However, there is a need to identify characteristics that can place patients in certain risk groups. In this study, the protein expression of multiple proteins in malignant melanoma tumors was studied, with the aim of identifying potential new candidate biomarkers. Representative samp

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35

Löbel, Franziska. "Identification of Prostate Cancer Metabolomic Markers by 1H HRMAS NMR Spectroscopy and Quantitative Immunohistochemistry." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-178285.

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Background Prostate cancer (PCa) is the most frequently diagnosed malignant disease among adult males in the USA and the second leading cause of cancer deaths in men. Due to the lack of diagnostic tools that are able to differentiate highly malignant and aggressive cases from indolent tumors, overtreatment has become very common in the era of prostate specific antigen (PSA) screening. New diagnostic methods to determine biological status, malignancy, aggressiveness and extent of PCa are urgently needed. 1H High Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy (1H HRMAS M

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36

Salah, Adeeb Ahmed Kassim. "Application of Complement Component 4d Immunohistochemistry to ABO-Compatible and ABO-Incompatible Liver Transplantation." Kyoto University, 2015. http://hdl.handle.net/2433/199180.

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Dobson, Craig Charles. "Immunohistochemistry, light and electron microscopy of the testis from the albino Swiss rat following vasectomy." Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366347.

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38

Herring, Ian Phillip. "Feline Leukemia Virus Detection in Corneal Tissues of Cats by Polymerase Chain Reaction and Immunohistochemistry." Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/46490.

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Corneal transplantation carries a high rate of success in the domestic cat and is an indicated treatment for specific corneal diseases in this species. The potential for iatrogenic transmission of viral diseases is a well-recognized problem in human corneal transplantation programs and screening donors for certain diseases is routine. Feline leukemia virus (FeLV) is a common agent of disease in domestic cats and available blood tests are highly effective in identification of infected individuals. This study investigates the presence of FeLV within corneal tissues of FeLV infected cats. S

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39

Okiro, Patricia Opon. "Morphological classification of childhood medulloblastomas with β-catenin immunohistochemistry and mycn fluorescent in situ hybridization". Master's thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/15733.

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Medulloblastoma is the most frequently occurring childhood malignant brain tumour, affecting 1 of 5 children presenting with a brain tumour, between the ages of 0 and 9 years. The basic prognostic stratification that relies on clinical and histological findings alone has proven unsatisfactory as an outcome predictor. Distinct molecular genetic profiles have been described, with four molecular variants of medulloblastoma with specific demographic and prognostic features. These are the WNT subgroup, SHH subgroup, Group 3 and Group 4 tumours. The aim of this study was to describe the expression s

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40

Peszkowski, Michael J. "Studies on oral immune reactions in the genetically mercury-sensitive BN rat and in the hyperplastic BN=(BNxLEW) graft-versus-host disease." Malmö, Sweden : Dept. of Oral Pathology, Centre for Oral Health Sciences, Lund University, 1996. http://books.google.com/books?id=xUlrAAAAMAAJ.

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Souza, Talita Floering Brêda [UNESP]. "Expressão dos fatores de crescimento obtidos do plasma rico em plaquetas, no tratamento de fraturas experimentais do radio de cães." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92209.

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Made available in DSpace on 2014-06-11T19:25:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-22Bitstream added on 2014-06-13T20:14:23Z : No. of bitstreams: 1 souza_tfb_me_araca.pdf: 990469 bytes, checksum: 2edda3c74283bbc14ffbed941509caad (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Fundação para o Desenvolvimento da UNESP (FUNDUNESP)<br>O objetivo deste trabalho foi o de avaliar a cicatrização óssea de fraturas experimentais do radio de cães, tratadas ou não com o PRP autógeno, por meio de estudos radiográfico, densitométrico e histológico; bem como

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42

Woo, Wing-shuen Nina. "Immunohistochemical analysis of Paks expression in ovarian cancer /." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36434309.

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Koo, Dicken D. H. "Ischaemia/reperfusion injury in renal transplantation." Thesis, University of Oxford, 1999. http://ora.ox.ac.uk/objects/uuid:e0177fd9-1504-4c76-b9fd-6e7ae0b6b466.

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Kidney transplants from both living-related (LRD) and living unrelated (LURD) donors have superior function and survival than transplants from cadaver donors. This may be unsurprising as kidneys from living donors are procured under optimal conditions, from healthy donors with minimal ischaemia times. In contrast, cadaver kidneys are obtained from traumatised donors and may experience extended periods of cold ischaemic storage before transplantation. An immunohistochemical analysis has been performed on biopsies obtained before, and immediately after transplantation, to investigate the potenti

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44

Al-Sharhan, Mouza Abdulla. "Prognostic factors in renal cell carcinoma." Thesis, University of Newcastle Upon Tyne, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285788.

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Cauli, Alberto. "The inflammatory milieu in chronic arthritis." Thesis, King's College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322233.

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46

Wong, Pik-wa Linda. "Optimization of detection of avian influenza virus in formalin fixed tissues by immunohistochemical methods." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42905333.

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47

Hughes, Rhome. "Immunohistochemical characterization of neuronal cilia in the rat central nervous system." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3136/.

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An anti-G"11 antibody was used to label neuronal cilia throughout the rat central nervous system. Immunoreactive cilia were observed in every examined region of the rat CNS, but not in monkey or mouse tissue. Antibodies to G"q and G"q/11 failed to label cilia. Immunoreactive cilia were observed as early as postnatal day 0 in spinal tissue, and postnatal day 3 in hypothalamic tissue. There was a statistically significant negative correlation between a region's mean cilium length and that region's distance to the nearest ventricle; regions nearest ventricles were those with the longest cilia. T

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48

Qiao, Guibin. "Molecular prognostic study of non-small cell lung cancer using high-throughput tissue microarray and immunohistochemistry." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=975693859.

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49

Cochran, Maria Karin. "Uptake Routes of Benzo[a]pyrene in an Estuarine Killifish: Cytochrome P4501A Immunohistochemistry using Whole Fish." W&M ScholarWorks, 1994. https://scholarworks.wm.edu/etd/1539617672.

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Ashok, Mahima. "Analysis of HER2 testing in breast cancer." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29711.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Griffin, Paul; Committee Member: Butera, Robert; Committee Member: Halpern, Michael; Committee Member: Nichols, Richard; Committee Member: Vidakovic, Brani. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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