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Rozprawy doktorskie na temat „Immunosuppressive agents Mechanism of action”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 1 lutego 2022

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1

Gudgeon, M. C. "Studies on the mechanism of action of cyclosporin A." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378279.

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2

Jones, Terence Edward. "Economically beneficial drug interactions with cyclosporin and tacroliumus : clinical studies in recipients of kidney and liver transplants." Title page, contents and abstract only, 2000. http://web4.library.adelaide.edu.au/theses/09PH/09phj79.pdf.

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Bibliography: leaves 234-257. Three separate clinical studies in organ transplant recipients are presented. The aims are to examine fundamental questions regarding the clinically and economically important pharmokinetic interaction between diltiazem and cyclosporin, an interaction widely utilised in organ transplantation. The data contained should assist the development of soundly based policies that will ensure a benefit exists before a sparing agent is coprescribed, and that the lowest effective dose of sparing agent is used.

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3

Lui, Sing-leung, and 雷聲亮. "The in vivo mechanism of actions of mycophenolate mofetil: insights from murine models of allograft rejection,endotoxemia, ischemia reperfusion injury and lupus nephritis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B26625374.

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Christie, Andrew W. "Mechanism of action of selected anti-lipolytic agents in adipocytes." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282761.

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Meister, Gabriel T. "Antiviral mechanism(s) of the experimental immunosuppressive agent leflunomide against human cytomegalovirus and polyomavirus." Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111428519.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xiii, 127 p.; also includes graphics (some col.) Includes bibliographical references (p. 113-127). Available online via OhioLINK's ETD Center

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6

Guo, Hong, and 郭紅. "Effects of anti-DNA antibodies on pleural mesothelial cells: in vitro studies to explore thepathogenetic mechanism of pulmonary lupus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B26631945.

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The Best M.Phil Thesis in the Faculties of Dentistry, Engineering, Medicine and Science (University of Hong Kong), Li Ka Shing Prize, 2001-2003.<br>published_or_final_version<br>abstract<br>toc<br>Medicine<br>Master<br>Master of Philosophy

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7

Hearn, Jessica M. "Integrating cell screening and mechanism of action data for organometallic anticancer agents." Thesis, University of Warwick, 2015. http://wrap.warwick.ac.uk/68071/.

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Both acquired and intrinsic drug resistance are established clinical problems in many areas of medicine. This is particularly evident with the growing resistance to platinum chemotherapy agents in cancer treatment programmes. New, alternative treatments for platinum-resistance patients are needed, with comparable potency, no platinum cross- resistance, better safety profiles and which target non-repairable areas of the cell, reducing acquired resistance. This thesis focuses on osmium- and iridium-based organometallic anticancer agents to fill this clinical need. Previous work has validated the

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8

HAMED, SAJA H. "EFFICACY AND MECHANISM OF ACTION OF A NEW TYROSINASE INHIBITORY AGENT." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1085566152.

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9

Lohmeyer, Matthias. "The mechanism of action of antitumour lipid agents related to platelet-activating factor (PAF)." Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319528.

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10

Xia, Yixuan. "Anticancer efficacy and mechanism of action studies of the potent plant cycloheptapeptide compounds mavacyocines." HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/817.

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Over the past 200 years, much attention has been paid to natural products for their great contribution in the industry of drug development as many of them have been shown effective against various diseased conditions in humans by virtue of their structural diversity and biological potency. Therefore, they are undeniably a rich resource for the discovery of novel bioactive compounds. To date, many of the mainstay anticancer agents often lead to undesirable side effects and/or develop rapid emergence of drug resistance. Therefore, new therapeutic remedies are desperately needed. In fact, many ac

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11

張麗 and Li Zhang. "Interactions of Bismuth complexes with biomolecules: insight into the mechanism of action of Bismuthantimicrobial agents." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B3124631X.

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12

Sun, Yang. "STUDY OF THE MECHANISM OF ACTION FOR Ru(II) POLYPYRIDYL COMPLEXES AS POTENTIAL ANTICANCER AGENTS." UKnowledge, 2018. https://uknowledge.uky.edu/chemistry_etds/97.

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Application of chemotherapeutic agents in current cancer treatment has been limited by adverse effects as poor selectivity results in systemic toxicity; most chemotherapy approaches also experience inherited or acquired drug resistance which lead to reduced treatment outcome. Research efforts have focused on the discovery of novel chemotherapies that overcome the limitations mentioned above. Ru(II) polypyridyl complexes with anti-cancer properties have been extensively studied as traditional cytotoxic agents and photodynamic therapy agents due to their photophysical and photochemical character

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13

Gruber, Susanne H. M. "Novel mechanism of action of antipsychotic drugs : effects on neuropeptides in rat brain /." Stockholm : [Karolinska institutets bibliotek], 2002. http://diss.kib.ki.se/2002/91-7349-229-9.

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14

Dierickx, Karen. "Contribution to the study of the efficacy and the mechanism of action of the alkylating peptide prolyl-m-sarcolysyl-p-fluorophenylalanine (PSF)." Doctoral thesis, Universite Libre de Bruxelles, 2008. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210390.

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The search for more effective treatment strategies in melanoma led to many new innovative approaches aiming at different molecular targets. Chemotherapy still remains the most effective treatment and many efforts are put in order to improve targeting and delivery of the chemotherapeutic agents. Among these, peptide conjugates of anticancer drugs were designed to increase stability, cell penetration, specificity and accumulation in cancer cells. We as well as others evaluated such a conjugate, termed PSF (L-prolyl-m-L-sarcolysyl-L-p-fluorophenylalanine-ethylester) in terms of its cytotoxicity i

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15

Nguyen, Albert Thu. "The molecular mechanism of action of bevirimat : a prototype HIV-1 maturation inhibitor /." Oklahoma City : [s.n.], 2009.

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16

Thowfeik, Fathima Shazna. "Targeting a Common Enemy: Toxic Cellular Mechanism of Novel Anti-cancer Agents that Alter DNA and Transcription." University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1460652655.

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17

Clarke, Alfred Alan. "The mechanism of action of mitomycin C and other agents and their relevance to the pathogenesis of Fanconi anaemia." Thesis, St George's, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312645.

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18

Wong, Michael. "Rational design of small molecule probes for investigating the mechanism of action of the chemotherapeutic agents CDDO and artemisinin." Thesis, University of Liverpool, 2015. http://livrepository.liverpool.ac.uk/2006368/.

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Adverse drug reactions (ADR) are a major concern for the pharmaceutical industry and health practitioners as they can cause morbidity and in severe cases mortality. ADRs are one of the major reasons why drugs fail during clinical trials so research directed at predicting ADRs to minimise failure is essential. The CDDO (2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oate) and the synthetic endoperoxide series are two promising classes that have potential for the treatment of cancers and malaria and may revolutionise treatment, within their fields, if approved for clinical use. The two main aims that

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19

Law, Yuen-kwan. "Study on the identification of small molecule activators of the autophagic pathway and elucidation of the mechanism of action." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42841793.

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20

Shao, Xingwu. "Reverse transcriptase assays for analysis of resistance to anti-HIV drugs and their mechanism of action /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-489-5.

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21

Ehrhardt, Katharina. "Redox-active 3-benzyl-menadiones as new antimalarial agents : studies on structure-activity relationships, antiparasitic potency and mechanism of action." Thesis, Strasbourg, 2014. http://www.theses.fr/2014STRAF020.

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Le paludisme reste une des maladies infectieuses les plus importantes au monde. Récemment, le laboratoire de Dr E. Davioud-Charvet a conçu des 3-Benzyl-Ménadiones substituées (benzylMD) comme agents antipaludiques prometteurs. Les études sur le mode d'action ont mis en évidenceque ces molecules déstabilisent l'équilibre redox des érythrocytes infectés en agissant comme agent catalytique redox (redox-Cycler), une stratégie prometteur pour le développement de nouveaux agents antipaludiques. Le travail de thèse présenté a caractérisé l'activité in vitro et le mécanisme d'action de tête de série,

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22

Law, Yuen-kwan, and 羅婉君. "Study on the identification of small molecule activators of the autophagic pathway and elucidation of the mechanism of action." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42841793.

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23

Jones, Amy R. "Using Drosophila melanogaster as a Whole-Model Animal System to Elucidate the Mechanism of Action of Novel Anticancer Agents." University of Cincinnati / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1353153948.

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24

Kalathottukaren, Manu Thomas. "Novel anticoagulant neutralizing agents for the management of bleeding : studies on the design, mechanism of action and their influence on blood coagulation." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61003.

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The full abstract for this thesis is available in the body of the thesis, and will be available when the embargo expires.<br>Medicine, Faculty of<br>Pathology and Laboratory Medicine, Department of<br>Graduate

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25

Katsoulas, Athanasia. "Design and mechanism of action of novel agents termed "combi-molecules" engineered for tandem targeting for Bcr-abl expressing leukemia cells." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111884.

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Bcr-abl expression being associated with anti-apoptotic signaling and expression of DNA repair enzymes, we surmised that single molecules capable of blocking abl tyrosine kinase (TK) function and damaging DNA should lead to compounds with potency superior to that of GleevecRTM. To this end, we designed novel agents termed "combi-molecules" programmed to not only behave as bcr-abl inhibitors on their own, but also to further degrade to another inhibitor and a DNA damaging species. The released inhibitor was designed to sustain bcr-abl inhibition following degradation of the combi-molecule and t

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26

Marcus, Monica M. "Mechanism of action of antipsychotic drugs: focus on the nucleus accumbens and the prefrontal cortex : an experimental study /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-284-5/.

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27

Ehrhardt, Katharina [Verfasser], and Michael [Akademischer Betreuer] Lanzer. "Redox-active 3-benzyl-menadiones as new antimalarial agents: Studies on structure-activity relationships, antiparasitic potency and mechanism of action / Katharina Ehrhardt ; Betreuer: Michael Lanzer." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178007898/34.

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28

Schroeder, Frederick Albert. "A Role for Histone Modification in the Mechanism of Action of Antidepressant and Stimulant Drugs: a Dissertation." eScholarship@UMMS, 2007. https://escholarship.umassmed.edu/gsbs_diss/370.

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Depression and stimulant drug addiction each result in massive losses of health, productivity and human lives every year. Despite decades of research, current treatment regimes for depression are ineffective in approximately half of all patients. Therapy available to stimulant drug addicts is largely ineffective and moreover, dedicated treatments for drug dependence (including abuse of cocaine) are non-existent. Thus, there is a pressing need to further understanding of the molecular mechanisms underlying these disorders in order to develop novel, targeted therapeutic strategies. Chromatin rem

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29

Lôme, Vincent. "Des agents chimiosensibilisants pour lutter contre la résistance aux antibiotiques chez les bactéries Gram-négatif : criblage et caractérisation." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0063.

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Les bactéries Gram-négatif possèdent une structure d'enveloppe, ainsi que des pompes d'efflux (i.e., systèmes de transport actif permettant de détoxifier la cellule bactérienne) qui les rendent naturellement résistantes aux antibiotiques. Ces deux caractéristiques constituent de véritables barrières qui s'opposent à l'accumulation d'une grande variété d'antibiotiques près de leur cible, à l'intérieur de la bactérie. La perturbation des mécanismes s’opposant à l’accumulation d’antibiotiques par des agents chimiosensibilisants représente une stratégie prometteuse.L’objectif de cette thèse était

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30

Léon, Pascale. "Etudes de relations structure-activite dans la serie des dimeres de 7h-pyridocarbazole, agents antitumoraux bis-intercalants de l'adn." Paris 6, 1987. http://www.theses.fr/1987PA066487.

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Brunel, Frédéric. "Synthèse, conception et élaboration de nouveaux systèmes dérivés de liquides ioniques antibactériens à base de phosphonium." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4087.

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Un récent rapport de l’OMS met en garde les autorités de santé sur l’émergence de résistances chez les bactéries et le développement de souches bactériennes multi-résistantes aux traitements antibiotiques actuels. La progression de ces phénomènes est dû à différents facteurs. L’environnement hospitalier concentre un usage important de traitements antibiotiques et représente ainsi un terreau favorable au développement de résistances chez les bactéries. Le staphylocoque doré, ainsi que sa souche résistante (SARM), s’avèrent problématiques et entraînent un grand nombre de maladies nosocomiales. D

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32

Bouarab, Lynda. "Évaluation du potentiel et de voies innovantes de mise en oeuvre de composés phénoliques antimicrobiens d’origine végétale pour la conservation des aliments." Thesis, Lyon, 2018. http://www.theses.fr/2018LYSE1084.

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Le règne végétal est une ressource renouvelable d'une large gamme de métabolites secondaires biologiquement actifs. Ces travaux de thèse proposent une stratégie multidisciplinaire d'évaluation du potentiel de composés phénoliques antimicrobiens d'origine végétale pour la conservation des aliments. Un criblage de l'activité antimicrobienne in vitro vis-à-vis de 8 souches de la flore pathogène et d'altération des aliments d'une centaine de molécules pures et une soixantaine d'extraits végétaux a d'abord permis de sélectionner les plus actifs. Différents mécanismes d'action vis-à-vis de S. aureus

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33

"Anti-tumour activity of trichosanthin and its mechanism of action." Chinese University of Hong Kong, 1990. http://library.cuhk.edu.hk/record=b5886644.

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by Wong Yick Fu.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 1990.<br>Bibliography: leaves 201-224.<br>Acknowledgments --- p.V<br>Summary --- p.vi<br>Publications --- p.ix<br>Statement of Originality --- p.X<br>List of Abbreviations --- p.xi<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Preamble --- p.2<br>Chapter 1.2 --- History of Trichosanthin --- p.6<br>Chapter 1.3 --- Preparation of Trichosanthin --- p.8<br>Chapter 1.4 --- Chemistry of Trichosanthin --- p.10<br>Chapter 1.4.1 --- Primary structure --- p.10<br>Chapter 1.4.2 --- Three dimensional structu

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34

Arac-Ozkan, Demet. "Mechanism of synaptotagmin action in neurotransmitter release." 2005. http://edissertations.library.swmed.edu/pdf/Arac-OzkanD121905/Arac-OzkanDemet.pdf.

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35

Kim, Mu-yong. "Design and biological evaluation of novel antitumor agents with mechanisms of action against topoisomerase II and/or G-quadruplexes." Thesis, 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3110634.

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36

Gírio, Patrícia Alexandra Madeira. "The role of ABC proteins in the mechanism of action of promising ruthenium anticancer agents." Master's thesis, 2017. http://hdl.handle.net/10451/31667.

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Tese de mestrado em Química, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2017<br>O cancro é um termo genérico para um vasto grupo de doenças que podem afetar qualquer parte do nosso corpo. Esta doença é definida pela proliferação anormal de células. Estas células anómalas podem invadir outros tecidos e órgãos formando assim metástases. O cancro, considerado uma doença mundial e que afeta diversas faixas etárias, continua a ser uma preocupação para a população e, nomeadamente, para os cientistas. A investigação nesta área já é longa e felizmente conta já com importan

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37

Domingues, Marco André Manso 1985. "Study of the mechanism of action of the antimicrobial peptide rBPI21 in gram-negative bacteria." Doctoral thesis, 2012. http://hdl.handle.net/10451/8633.

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Tese de doutoramento, Ciências Biomédicas (Bioquímica Médica), Universidade de Lisboa, Faculdade de Medicina, 2012<br>Antimicrobial peptides (AMPs) are currently looked as new candidates to overcome the bacterial resistance against therapeutic antibiotics. However, their mechanism of action remains unclear, despite several theories having been proposed. The understanding of the processes that govern AMPs activity is the best way to provide rational design of new antibiotics for further clinical use against bacterial infections. Human AMPs are part of the innate immune system and synthetic vers

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38

Rasool, Yusuf. "An evaluation of the anti-inflammatory activity and mechanism of action of three novel auronofin derivatives." 2008. http://upetd.up.ac.za/thesis/available/etd-02242009-160331.

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